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Gene Dmel\CG9603

General Information
Symbol	Dmel\CG9603	Species	D. melanogaster
Name		Annotation symbol	CG9603
Feature type	protein_coding_gene	FlyBase ID	FBgn0040529
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	84F13-84F13	Sequence location	3R:4,165,666..4,166,765 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG9603 (FBgn0040529). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cytochrome-c oxidase activity. Based on sequence similarity, it is predicted to be involved in the biological process: mitochondrial electron transport, cytochrome c to oxygen. 4 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cytochrome c oxidase, subunit VIIa. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635947_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG9603. Gene sequence location is 3R:4165666..4166765.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84F13-84F13   Limits computationally determined from genome sequence between P{EP}EP833 and P{lacW}l(3)L4740L4740
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG9603 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG9603-RA FBtr0081855  NM_143927   621   89 CG9603-RB FBtr0305680  NM_001260057   566   98
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG9603-PA   FBpp0081344   9.9   89   10.71     NP_652184   AAF54227 CG9603-PB   FBpp0296960   10.8   98   10.16     NP_001246986   AFH06305
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome c oxidase, subunit VIIa (IPR003177) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME09603
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54227   AE014297 AFH06305   AI114387   AI256863   AI259229   AI260484   AI293271   AI294362   AY071267 AAL48889   BI164665   BI172082   BI234364   BI234678   BI234700   BI240371   BI242360   BI354186   BI356121   BI361893   BI484591   BI565649   BI567474   BI567482   BI575267   BI587904   BI588002   BI612610   BI617556   BI626534   BI637657   BP542013   BP543869   BP544570   BP544571   BP546125   BP546616   BP547458   BP547633   BP547774   BP551394   BP551395   BP551839   BP551840   BP555049   BP555167   BP555168   BT058048   BT120075   CK657006   CO179637   CO181394   CO182746   CO183743   CO189486   CO191128   CO192774   CO194001   CO194365   CO266132   CO266133   CO277529   CO312907   CO324373   CO325235   CO327266   CO327635   CO327687   CO338293   CZ480981   EC065103   EC069967   EC072970   EC080361   EC086255   EC198987   EC201732   EC243689   EC256936   EC256983   EC259900   EC265302   EL885991   EV581065   EV583384   EV583765   EV599739
UniProtKB/Swiss-Prot	Q9VHS2
UniProtKB/TrEMBL	Q8SYW9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1770.3 Larval Midgut    4044.9 Larval Hindgut    3630.2 Larval Malpighian Tubules    3066.9 Larval Fat Body    1425.2 Larval Salivary Gland    3355.7 Larval Trachea    1956.55 Larval Carcass    3715.2 Adult Head    2836 Adult Eye    2778.775 Adult Brain    2166.1 Adult Thoracic-Abdominal Ganglion    3005.2 Adult Crop    3281.5 Adult Midgut    3250.5 Adult Hindgut    3938.4 Adult Malpighian Tubules    2952 Adult Fat Body    4006.3 Adult Salivary Gland    6570 Adult Heart    3043.95 Adult VirginFemale Spermatheca    4028.4 Adult InseminatedFemale Spermatheca    3736.7 Adult Ovary    1550.7 Adult Testis    809.1 Adult Male Accessory Gland    2786.4 Adult Carcass    3020 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1770.3) Larval Midgut  (4044.9) Larval Hindgut  (3630.2) Larval Malpighian Tubules  (3066.9) Larval Fat Body  (1425.2) Larval Salivary Gland  (3355.7) Larval Trachea  (1956.55) Larval Carcass  (3715.2) Adult Head  (2836) Adult Eye  (2778.775) Adult Brain  (2166.1) Adult Thoracic-Abdominal Ganglion  (3005.2) Adult Crop  (3281.5) Adult Midgut  (3250.5) Adult Hindgut  (3938.4) Adult Malpighian Tubules  (2952) Adult Fat Body  (4006.3) Adult Salivary Gland  (6570) Adult Heart  (3043.95) Adult VirginFemale Spermatheca  (4028.4) Adult InseminatedFemale Spermatheca  (3736.7) Adult Ovary  (1550.7) Adult Testis  (809.1) Adult Male Accessory Gland  (2786.4) Adult Carcass  (3020) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1770.3) Larval Midgut  (4044.9) Larval Hindgut  (3630.2) Larval Malpighian Tubules  (3066.9) Larval Fat Body  (1425.2) Larval Salivary Gland  (3355.7) Larval Trachea  (1956.55) Larval Carcass  (3715.2) Adult Head  (2836) Adult Eye  (2778.775) Adult Brain  (2166.1) Adult Thoracic-Abdominal Ganglion  (3005.2) Adult Crop  (3281.5) Adult Midgut  (3250.5) Adult Hindgut  (3938.4) Adult Malpighian Tubules  (2952) Adult Fat Body  (4006.3) Adult Salivary Gland  (6570) Adult Heart  (3043.95) Adult VirginFemale Spermatheca  (4028.4) Adult InseminatedFemale Spermatheca  (3736.7) Adult Ovary  (1550.7) Adult Testis    809.1 Adult Male Accessory Gland  (2786.4) Adult Carcass  (3020) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1770.3 Larval Midgut    4044.9 Larval Hindgut    3630.2 Larval Malpighian Tubules    3066.9 Larval Fat Body    1425.2 Larval Salivary Gland    3355.7 Larval Trachea    1956.55 Larval Carcass    3715.2 Adult Head    2836 Adult Eye    2778.775 Adult Brain    2166.1 Adult Thoracic-Abdominal Ganglion    3005.2 Adult Crop    3281.5 Adult Midgut    3250.5 Adult Hindgut    3938.4 Adult Malpighian Tubules    2952 Adult Fat Body    4006.3 Adult Salivary Gland    6570 Adult Heart    3043.95 Adult VirginFemale Spermatheca    4028.4 Adult InseminatedFemale Spermatheca    3736.7 Adult Ovary    1550.7 Adult Testis    809.1 Adult Male Accessory Gland    2786.4 Adult Carcass    3020 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1770.3 Larval Midgut    4044.9 Larval Hindgut    3630.2 Larval Malpighian Tubules    3066.9 Larval Fat Body    1425.2 Larval Salivary Gland    3355.7 Larval Trachea    1956.55 Larval Carcass    3715.2 Adult Head    2836 Adult Eye    2778.775 Adult Brain    2166.1 Adult Thoracic-Abdominal Ganglion    3005.2 Adult Crop    3281.5 Adult Midgut    3250.5 Adult Hindgut    3938.4 Adult Malpighian Tubules    2952 Adult Fat Body    4006.3 Adult Salivary Gland    6570 Adult Heart    3043.95 Adult VirginFemale Spermatheca    4028.4 Adult InseminatedFemale Spermatheca    3736.7 Adult Ovary    1550.7 Adult Testis    809.1 Adult Male Accessory Gland    2786.4 Adult Carcass    3020 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1770.3) Larval Midgut  (4044.9) Larval Hindgut  (3630.2) Larval Malpighian Tubules  (3066.9) Larval Fat Body  (1425.2) Larval Salivary Gland  (3355.7) Larval Trachea  (1956.55) Larval Carcass  (3715.2) Adult Head  (2836) Adult Eye  (2778.775) Adult Brain  (2166.1) Adult Thoracic-Abdominal Ganglion  (3005.2) Adult Crop  (3281.5) Adult Midgut  (3250.5) Adult Hindgut  (3938.4) Adult Malpighian Tubules  (2952) Adult Fat Body  (4006.3) Adult Salivary Gland  (6570) Adult Heart  (3043.95) Adult VirginFemale Spermatheca  (4028.4) Adult InseminatedFemale Spermatheca  (3736.7) Adult Ovary  (1550.7) Adult Testis  809.1 Adult Male Accessory Gland  (2786.4) Adult Carcass  (3020) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1770.3) Larval Midgut  (4044.9) Larval Hindgut  (3630.2) Larval Malpighian Tubules  (3066.9) Larval Fat Body  1425.2 Larval Salivary Gland  (3355.7) Larval Trachea  (1956.55) Larval Carcass  (3715.2) Adult Head  (2836) Adult Eye  (2778.775) Adult Brain  (2166.1) Adult Thoracic-Abdominal Ganglion  (3005.2) Adult Crop  (3281.5) Adult Midgut  (3250.5) Adult Hindgut  (3938.4) Adult Malpighian Tubules  (2952) Adult Fat Body  (4006.3) Adult Salivary Gland  (6570) Adult Heart  (3043.95) Adult VirginFemale Spermatheca  (4028.4) Adult InseminatedFemale Spermatheca  (3736.7) Adult Ovary  1550.7 Adult Testis    809.1 Adult Male Accessory Gland  (2786.4) Adult Carcass  (3020) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1770.3 Larval Midgut    4044.9 Larval Hindgut    3630.2 Larval Malpighian Tubules    3066.9 Larval Fat Body    1425.2 Larval Salivary Gland    3355.7 Larval Trachea    1956.55 Larval Carcass    3715.2 Adult Head    2836 Adult Eye    2778.775 Adult Brain    2166.1 Adult Thoracic-Abdominal Ganglion    3005.2 Adult Crop    3281.5 Adult Midgut    3250.5 Adult Hindgut    3938.4 Adult Malpighian Tubules    2952 Adult Fat Body    4006.3 Adult Salivary Gland    6570 Adult Heart    3043.95 Adult VirginFemale Spermatheca    4028.4 Adult InseminatedFemale Spermatheca    3736.7 Adult Ovary    1550.7 Adult Testis    809.1 Adult Male Accessory Gland    2786.4 Adult Carcass    3020 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2836   NA  Eye    2778.775   NA  Brain    2166.1   1770.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3005.2   NA  Crop    3281.5   4044.9  Midgut    3250.5   3630.2  Hindgut    3938.4   3066.9  Malpighian Tubules    2952   1425.2  Fat Body    4006.3   3355.7  Salivary Gland    6570   NA  Heart    3043.95   1956.55  Trachea    NA   NA  VirginFemale Spermatheca    4028.4   NA  InseminatedFemale Spermatheca    3736.7   NA  Ovary    1550.7   NA  Testis    809.1   NA  Male Accessory Gland    2786.4   3715.2  Carcass    3020 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    268 central nervous system, larvae L3    196 central nervous system, pupae P8    252 head, virgin 1-day female    382 head, virgin 4-day female    246 head, virgin 20-day female    292 head, mated 1-day female    266 head, mated 4-day female    297 head, mated 20-day female    226 head, mated 1-day male    401 head, mated 4-day male    431 head, mated 20-day male    421 salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    95 digestive system, larvae L3 wandering    193 digestive system, 1-day adult    645 digestive system, 4-day adult    392 digestive system, 20-day adult    343 fat body, larvae L3 wandering    107 fat body, white prepupae    109 fat body, pupae P8    196 carcass, larvae L3 wandering    176 carcass, 1-day adult    247 carcass, 4-day adult    225 carcass, 20-day adult    232 ovary, virgin 4-day female    264 ovary, mated 4-day female    185 testis, mated 4-day male    203 accessory gland, mated 4-day male    207 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (268) central nervous system, larvae L3  (196) central nervous system, pupae P8  (252) head, virgin 1-day female  (382) head, virgin 4-day female  (246) head, virgin 20-day female  (292) head, mated 1-day female  (266) head, mated 4-day female  (297) head, mated 20-day female  (226) head, mated 1-day male  (401) head, mated 4-day male  (431) head, mated 20-day male  (421) salivary gland, larvae L3 wandering  (96) salivary gland, white prepupae  (95) digestive system, larvae L3 wandering  (193) digestive system, 1-day adult  (645) digestive system, 4-day adult  (392) digestive system, 20-day adult  (343) fat body, larvae L3 wandering  (107) fat body, white prepupae  (109) fat body, pupae P8  (196) carcass, larvae L3 wandering  (176) carcass, 1-day adult  (247) carcass, 4-day adult  (225) carcass, 20-day adult  (232) ovary, virgin 4-day female  (264) ovary, mated 4-day female  (185) testis, mated 4-day male  (203) accessory gland, mated 4-day male  (207) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (268) central nervous system, larvae L3  (196) central nervous system, pupae P8  (252) head, virgin 1-day female  (382) head, virgin 4-day female  (246) head, virgin 20-day female  (292) head, mated 1-day female  (266) head, mated 4-day female  (297) head, mated 20-day female  (226) head, mated 1-day male  (401) head, mated 4-day male  (431) head, mated 20-day male  (421) salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    95 digestive system, larvae L3 wandering  (193) digestive system, 1-day adult  (645) digestive system, 4-day adult  (392) digestive system, 20-day adult  (343) fat body, larvae L3 wandering  107 fat body, white prepupae  (109) fat body, pupae P8  (196) carcass, larvae L3 wandering  (176) carcass, 1-day adult  (247) carcass, 4-day adult  (225) carcass, 20-day adult  (232) ovary, virgin 4-day female  (264) ovary, mated 4-day female  (185) testis, mated 4-day male  (203) accessory gland, mated 4-day male  (207) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    268 central nervous system, larvae L3    196 central nervous system, pupae P8    252 head, virgin 1-day female    382 head, virgin 4-day female    246 head, virgin 20-day female    292 head, mated 1-day female    266 head, mated 4-day female    297 head, mated 20-day female    226 head, mated 1-day male    401 head, mated 4-day male    431 head, mated 20-day male    421 salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    95 digestive system, larvae L3 wandering    193 digestive system, 1-day adult    645 digestive system, 4-day adult    392 digestive system, 20-day adult    343 fat body, larvae L3 wandering    107 fat body, white prepupae    109 fat body, pupae P8    196 carcass, larvae L3 wandering    176 carcass, 1-day adult    247 carcass, 4-day adult    225 carcass, 20-day adult    232 ovary, virgin 4-day female    264 ovary, mated 4-day female    185 testis, mated 4-day male    203 accessory gland, mated 4-day male    207 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    268 central nervous system, larvae L3    196 central nervous system, pupae P8    252 head, virgin 1-day female    382 head, virgin 4-day female    246 head, virgin 20-day female    292 head, mated 1-day female    266 head, mated 4-day female    297 head, mated 20-day female    226 head, mated 1-day male    401 head, mated 4-day male    431 head, mated 20-day male    421 salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    95 digestive system, larvae L3 wandering    193 digestive system, 1-day adult    645 digestive system, 4-day adult    392 digestive system, 20-day adult    343 fat body, larvae L3 wandering    107 fat body, white prepupae    109 fat body, pupae P8    196 carcass, larvae L3 wandering    176 carcass, 1-day adult    247 carcass, 4-day adult    225 carcass, 20-day adult    232 ovary, virgin 4-day female    264 ovary, mated 4-day female    185 testis, mated 4-day male    203 accessory gland, mated 4-day male    207 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (268) central nervous system, larvae L3  (196) central nervous system, pupae P8  (252) head, virgin 1-day female  (382) head, virgin 4-day female  (246) head, virgin 20-day female  (292) head, mated 1-day female  (266) head, mated 4-day female  (297) head, mated 20-day female  (226) head, mated 1-day male  (401) head, mated 4-day male  (431) head, mated 20-day male  (421) salivary gland, larvae L3 wandering  (96) salivary gland, white prepupae  (95) digestive system, larvae L3 wandering  (193) digestive system, 1-day adult  (645) digestive system, 4-day adult  (392) digestive system, 20-day adult  (343) fat body, larvae L3 wandering  (107) fat body, white prepupae  (109) fat body, pupae P8  (196) carcass, larvae L3 wandering  (176) carcass, 1-day adult  (247) carcass, 4-day adult  (225) carcass, 20-day adult  (232) ovary, virgin 4-day female  (264) ovary, mated 4-day female  (185) testis, mated 4-day male  (203) accessory gland, mated 4-day male  (207) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (268) central nervous system, larvae L3  (196) central nervous system, pupae P8  (252) head, virgin 1-day female  (382) head, virgin 4-day female  (246) head, virgin 20-day female  (292) head, mated 1-day female  (266) head, mated 4-day female  (297) head, mated 20-day female  (226) head, mated 1-day male  (401) head, mated 4-day male  (431) head, mated 20-day male  (421) salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    95 digestive system, larvae L3 wandering  (193) digestive system, 1-day adult  (645) digestive system, 4-day adult  (392) digestive system, 20-day adult  (343) fat body, larvae L3 wandering  107 fat body, white prepupae  109 fat body, pupae P8  (196) carcass, larvae L3 wandering  (176) carcass, 1-day adult  (247) carcass, 4-day adult  (225) carcass, 20-day adult  (232) ovary, virgin 4-day female  (264) ovary, mated 4-day female  (185) testis, mated 4-day male  (203) accessory gland, mated 4-day male  (207) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    268 central nervous system, larvae L3    196 central nervous system, pupae P8    252 head, virgin 1-day female    382 head, virgin 4-day female    246 head, virgin 20-day female    292 head, mated 1-day female    266 head, mated 4-day female    297 head, mated 20-day female    226 head, mated 1-day male    401 head, mated 4-day male    431 head, mated 20-day male    421 salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    95 digestive system, larvae L3 wandering    193 digestive system, 1-day adult    645 digestive system, 4-day adult    392 digestive system, 20-day adult    343 fat body, larvae L3 wandering    107 fat body, white prepupae    109 fat body, pupae P8    196 carcass, larvae L3 wandering    176 carcass, 1-day adult    247 carcass, 4-day adult    225 carcass, 20-day adult    232 ovary, virgin 4-day female    264 ovary, mated 4-day female    185 testis, mated 4-day male    203 accessory gland, mated 4-day male    207 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    160 embryo 02-04hr    76 embryo 04-06hr    141 embryo 06-08hr    178 embryo 08-10hr    193 embryo 10-12hr    222 embryo 12-14hr    258 embryo 14-16hr    306 embryo 16-18hr    372 embryo 18-20hr    340 embryo 20-22hr    432 embryo 22-24hr    502 larva L1    654 larva L2    684 larva L3 12hr old    572 larva L3 puffstage 1-2    412 larva L3 puffstage 3-6    205 larva L3 puffstage 7-9    217 white prepupae new    174 white prepupae 12hr    151 white prepupae 24hr    158 pupae 2d postWPP    177 pupae 3d postWPP    199 pupae 4d postWPP    246 adult male 01day    270 adult male 05day    232 adult male 30day    236 adult female 01day    287 adult female 05day    252 adult female 30day    240 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (160) embryo 02-04hr  (76) embryo 04-06hr  (141) embryo 06-08hr  (178) embryo 08-10hr  (193) embryo 10-12hr  (222) embryo 12-14hr  (258) embryo 14-16hr  (306) embryo 16-18hr  (372) embryo 18-20hr  (340) embryo 20-22hr  (432) embryo 22-24hr  (502) larva L1  (654) larva L2  (684) larva L3 12hr old  (572) larva L3 puffstage 1-2  (412) larva L3 puffstage 3-6  (205) larva L3 puffstage 7-9  (217) white prepupae new  (174) white prepupae 12hr  (151) white prepupae 24hr  (158) pupae 2d postWPP  (177) pupae 3d postWPP  (199) pupae 4d postWPP  (246) adult male 01day  (270) adult male 05day  (232) adult male 30day  (236) adult female 01day  (287) adult female 05day  (252) adult female 30day  (240) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (160) embryo 02-04hr    76 embryo 04-06hr  (141) embryo 06-08hr  (178) embryo 08-10hr  (193) embryo 10-12hr  (222) embryo 12-14hr  (258) embryo 14-16hr  (306) embryo 16-18hr  (372) embryo 18-20hr  (340) embryo 20-22hr  (432) embryo 22-24hr  (502) larva L1  (654) larva L2  (684) larva L3 12hr old  (572) larva L3 puffstage 1-2  (412) larva L3 puffstage 3-6  (205) larva L3 puffstage 7-9  (217) white prepupae new  (174) white prepupae 12hr  (151) white prepupae 24hr  (158) pupae 2d postWPP  (177) pupae 3d postWPP  (199) pupae 4d postWPP  (246) adult male 01day  (270) adult male 05day  (232) adult male 30day  (236) adult female 01day  (287) adult female 05day  (252) adult female 30day  (240) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    160 embryo 02-04hr    76 embryo 04-06hr    141 embryo 06-08hr    178 embryo 08-10hr    193 embryo 10-12hr    222 embryo 12-14hr    258 embryo 14-16hr    306 embryo 16-18hr    372 embryo 18-20hr    340 embryo 20-22hr    432 embryo 22-24hr    502 larva L1    654 larva L2    684 larva L3 12hr old    572 larva L3 puffstage 1-2    412 larva L3 puffstage 3-6    205 larva L3 puffstage 7-9    217 white prepupae new    174 white prepupae 12hr    151 white prepupae 24hr    158 pupae 2d postWPP    177 pupae 3d postWPP    199 pupae 4d postWPP    246 adult male 01day    270 adult male 05day    232 adult male 30day    236 adult female 01day    287 adult female 05day    252 adult female 30day    240 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    160 embryo 02-04hr    76 embryo 04-06hr    141 embryo 06-08hr    178 embryo 08-10hr    193 embryo 10-12hr    222 embryo 12-14hr    258 embryo 14-16hr    306 embryo 16-18hr    372 embryo 18-20hr    340 embryo 20-22hr    432 embryo 22-24hr    502 larva L1    654 larva L2    684 larva L3 12hr old    572 larva L3 puffstage 1-2    412 larva L3 puffstage 3-6    205 larva L3 puffstage 7-9    217 white prepupae new    174 white prepupae 12hr    151 white prepupae 24hr    158 pupae 2d postWPP    177 pupae 3d postWPP    199 pupae 4d postWPP    246 adult male 01day    270 adult male 05day    232 adult male 30day    236 adult female 01day    287 adult female 05day    252 adult female 30day    240 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (160) embryo 02-04hr  (76) embryo 04-06hr  (141) embryo 06-08hr  (178) embryo 08-10hr  (193) embryo 10-12hr  (222) embryo 12-14hr  (258) embryo 14-16hr  (306) embryo 16-18hr  (372) embryo 18-20hr  (340) embryo 20-22hr  (432) embryo 22-24hr  (502) larva L1  (654) larva L2  (684) larva L3 12hr old  (572) larva L3 puffstage 1-2  (412) larva L3 puffstage 3-6  (205) larva L3 puffstage 7-9  (217) white prepupae new  (174) white prepupae 12hr  (151) white prepupae 24hr  (158) pupae 2d postWPP  (177) pupae 3d postWPP  (199) pupae 4d postWPP  (246) adult male 01day  (270) adult male 05day  (232) adult male 30day  (236) adult female 01day  (287) adult female 05day  (252) adult female 30day  (240) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (160) embryo 02-04hr    76 embryo 04-06hr  141 embryo 06-08hr  (178) embryo 08-10hr  (193) embryo 10-12hr  (222) embryo 12-14hr  (258) embryo 14-16hr  (306) embryo 16-18hr  (372) embryo 18-20hr  (340) embryo 20-22hr  (432) embryo 22-24hr  (502) larva L1  (654) larva L2  (684) larva L3 12hr old  (572) larva L3 puffstage 1-2  (412) larva L3 puffstage 3-6  (205) larva L3 puffstage 7-9  (217) white prepupae new  (174) white prepupae 12hr  (151) white prepupae 24hr  (158) pupae 2d postWPP  (177) pupae 3d postWPP  (199) pupae 4d postWPP  (246) adult male 01day  (270) adult male 05day  (232) adult male 30day  (236) adult female 01day  (287) adult female 05day  (252) adult female 30day  (240) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    160 embryo 02-04hr    76 embryo 04-06hr    141 embryo 06-08hr    178 embryo 08-10hr    193 embryo 10-12hr    222 embryo 12-14hr    258 embryo 14-16hr    306 embryo 16-18hr    372 embryo 18-20hr    340 embryo 20-22hr    432 embryo 22-24hr    502 larva L1    654 larva L2    684 larva L3 12hr old    572 larva L3 puffstage 1-2    412 larva L3 puffstage 3-6    205 larva L3 puffstage 7-9    217 white prepupae new    174 white prepupae 12hr    151 white prepupae 24hr    158 pupae 2d postWPP    177 pupae 3d postWPP    199 pupae 4d postWPP    246 adult male 01day    270 adult male 05day    232 adult male 30day    236 adult female 01day    287 adult female 05day    252 adult female 30day    240 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    370 Schneider line 2 Sg4    291 embryonic 1182-4H    232 embryonic GM2    333 embryonic Kc167    240 embryonic S1    278 embryonic S3    595 leg disc CME L1    296 wing disc CME-W2    850 wing disc ML-DmD8    295 wing disc ML-DmD9    290 wing disc ML-DmD16-c3    314 wing disc ML-DmD21    349 wing disc ML-DmD32    311 haltere disc ML-DmD17-c3    569 eye-antennal disc ML-DmD11    677 antennal disc ML-DmD20-c5    494 mixed discs ML-DmD4-c1    281 CNS ML-DmBG1-c1    398 CNS ML-DmBG2-c2    174 tumorous blood cells mbn2    265 ovary fGS/OSS    193 ovary OSC    313 ovary OSS    131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (370) Schneider line 2 Sg4  (291) embryonic 1182-4H  (232) embryonic GM2  (333) embryonic Kc167  (240) embryonic S1  (278) embryonic S3  (595) leg disc CME L1  (296) wing disc CME-W2  (850) wing disc ML-DmD8  (295) wing disc ML-DmD9  (290) wing disc ML-DmD16-c3  (314) wing disc ML-DmD21  (349) wing disc ML-DmD32  (311) haltere disc ML-DmD17-c3  (569) eye-antennal disc ML-DmD11  (677) antennal disc ML-DmD20-c5  (494) mixed discs ML-DmD4-c1  (281) CNS ML-DmBG1-c1  (398) CNS ML-DmBG2-c2  (174) tumorous blood cells mbn2  (265) ovary fGS/OSS  (193) ovary OSC  (313) ovary OSS  (131) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (370) Schneider line 2 Sg4  (291) embryonic 1182-4H  (232) embryonic GM2  (333) embryonic Kc167  (240) embryonic S1  (278) embryonic S3  (595) leg disc CME L1  (296) wing disc CME-W2  (850) wing disc ML-DmD8  (295) wing disc ML-DmD9  (290) wing disc ML-DmD16-c3  (314) wing disc ML-DmD21  (349) wing disc ML-DmD32  (311) haltere disc ML-DmD17-c3  (569) eye-antennal disc ML-DmD11  (677) antennal disc ML-DmD20-c5  (494) mixed discs ML-DmD4-c1  (281) CNS ML-DmBG1-c1  (398) CNS ML-DmBG2-c2  (174) tumorous blood cells mbn2  (265) ovary fGS/OSS  (193) ovary OSC  (313) ovary OSS  (131) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    370 Schneider line 2 Sg4    291 embryonic 1182-4H    232 embryonic GM2    333 embryonic Kc167    240 embryonic S1    278 embryonic S3    595 leg disc CME L1    296 wing disc CME-W2    850 wing disc ML-DmD8    295 wing disc ML-DmD9    290 wing disc ML-DmD16-c3    314 wing disc ML-DmD21    349 wing disc ML-DmD32    311 haltere disc ML-DmD17-c3    569 eye-antennal disc ML-DmD11    677 antennal disc ML-DmD20-c5    494 mixed discs ML-DmD4-c1    281 CNS ML-DmBG1-c1    398 CNS ML-DmBG2-c2    174 tumorous blood cells mbn2    265 ovary fGS/OSS    193 ovary OSC    313 ovary OSS    131 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    370 Schneider line 2 Sg4    291 embryonic 1182-4H    232 embryonic GM2    333 embryonic Kc167    240 embryonic S1    278 embryonic S3    595 leg disc CME L1    296 wing disc CME-W2    850 wing disc ML-DmD8    295 wing disc ML-DmD9    290 wing disc ML-DmD16-c3    314 wing disc ML-DmD21    349 wing disc ML-DmD32    311 haltere disc ML-DmD17-c3    569 eye-antennal disc ML-DmD11    677 antennal disc ML-DmD20-c5    494 mixed discs ML-DmD4-c1    281 CNS ML-DmBG1-c1    398 CNS ML-DmBG2-c2    174 tumorous blood cells mbn2    265 ovary fGS/OSS    193 ovary OSC    313 ovary OSS    131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (370) Schneider line 2 Sg4  (291) embryonic 1182-4H  (232) embryonic GM2  (333) embryonic Kc167  (240) embryonic S1  (278) embryonic S3  (595) leg disc CME L1  (296) wing disc CME-W2  (850) wing disc ML-DmD8  (295) wing disc ML-DmD9  (290) wing disc ML-DmD16-c3  (314) wing disc ML-DmD21  (349) wing disc ML-DmD32  (311) haltere disc ML-DmD17-c3  (569) eye-antennal disc ML-DmD11  (677) antennal disc ML-DmD20-c5  (494) mixed discs ML-DmD4-c1  (281) CNS ML-DmBG1-c1  (398) CNS ML-DmBG2-c2  (174) tumorous blood cells mbn2  (265) ovary fGS/OSS  (193) ovary OSC  (313) ovary OSS  (131) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (370) Schneider line 2 Sg4  (291) embryonic 1182-4H  (232) embryonic GM2  (333) embryonic Kc167  (240) embryonic S1  (278) embryonic S3  (595) leg disc CME L1  (296) wing disc CME-W2  (850) wing disc ML-DmD8  (295) wing disc ML-DmD9  (290) wing disc ML-DmD16-c3  (314) wing disc ML-DmD21  (349) wing disc ML-DmD32  (311) haltere disc ML-DmD17-c3  (569) eye-antennal disc ML-DmD11  (677) antennal disc ML-DmD20-c5  (494) mixed discs ML-DmD4-c1  (281) CNS ML-DmBG1-c1  (398) CNS ML-DmBG2-c2  (174) tumorous blood cells mbn2  (265) ovary fGS/OSS  (193) ovary OSC  (313) ovary OSS  131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    370 Schneider line 2 Sg4    291 embryonic 1182-4H    232 embryonic GM2    333 embryonic Kc167    240 embryonic S1    278 embryonic S3    595 leg disc CME L1    296 wing disc CME-W2    850 wing disc ML-DmD8    295 wing disc ML-DmD9    290 wing disc ML-DmD16-c3    314 wing disc ML-DmD21    349 wing disc ML-DmD32    311 haltere disc ML-DmD17-c3    569 eye-antennal disc ML-DmD11    677 antennal disc ML-DmD20-c5    494 mixed discs ML-DmD4-c1    281 CNS ML-DmBG1-c1    398 CNS ML-DmBG2-c2    174 tumorous blood cells mbn2    265 ovary fGS/OSS    193 ovary OSC    313 ovary OSS    131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    107 cold shock, 4-day adult    74 heat shock, 4-day adult    385 Cadmium 50 mM 6 hrs, larvae L3    527 Cadmium 50 mM 12 hrs, larvae L3    596 Cadmium 50 mM 48 hrs, 4-day adult    481 Cadmium 100 mM 48 hrs, 4-day adult    182 Copper 0.5 mM 12 hrs, larvae L3    209 Copper 15 mM 48 hrs, 4-day adult    165 Zinc 5 mM 12 hrs, larvae L3    232 Zinc 4.5 mM 48 hrs, 4-day adult    189 Ethanol 2.5% 3 hrs, larvae L3    190 Ethanol 5% 3 hrs, larvae L3    883 Ethanol 10% 3 hrs, larvae L3    596 Caffeine 1.5 mg/ml 4 hrs, larvae L3    763 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    211 Caffeine 25 mg/ml 48 hrs, 4-day adult    103 Paraquat 5 mM 48 hrs, 4-day adult    214 Paraquat 10 mM 48 hrs, 4-day adult    220 Rotenone 2 μg 12 hrs, larvae L3    815 Rotenone 8 μg 12 hrs, larvae L3    628 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (107) cold shock, 4-day adult  (74) heat shock, 4-day adult  (385) Cadmium 50 mM 6 hrs, larvae L3  (527) Cadmium 50 mM 12 hrs, larvae L3  (596) Cadmium 50 mM 48 hrs, 4-day adult  (481) Cadmium 100 mM 48 hrs, 4-day adult  (182) Copper 0.5 mM 12 hrs, larvae L3  (209) Copper 15 mM 48 hrs, 4-day adult  (165) Zinc 5 mM 12 hrs, larvae L3  (232) Zinc 4.5 mM 48 hrs, 4-day adult  (189) Ethanol 2.5% 3 hrs, larvae L3  (190) Ethanol 5% 3 hrs, larvae L3  (883) Ethanol 10% 3 hrs, larvae L3  (596) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (763) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (211) Caffeine 25 mg/ml 48 hrs, 4-day adult  (103) Paraquat 5 mM 48 hrs, 4-day adult  (214) Paraquat 10 mM 48 hrs, 4-day adult  (220) Rotenone 2 μg 12 hrs, larvae L3  (815) Rotenone 8 μg 12 hrs, larvae L3  (628) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  107 cold shock, 4-day adult    74 heat shock, 4-day adult  (385) Cadmium 50 mM 6 hrs, larvae L3  (527) Cadmium 50 mM 12 hrs, larvae L3  (596) Cadmium 50 mM 48 hrs, 4-day adult  (481) Cadmium 100 mM 48 hrs, 4-day adult  (182) Copper 0.5 mM 12 hrs, larvae L3  (209) Copper 15 mM 48 hrs, 4-day adult  (165) Zinc 5 mM 12 hrs, larvae L3  (232) Zinc 4.5 mM 48 hrs, 4-day adult  (189) Ethanol 2.5% 3 hrs, larvae L3  (190) Ethanol 5% 3 hrs, larvae L3  (883) Ethanol 10% 3 hrs, larvae L3  (596) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (763) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (211) Caffeine 25 mg/ml 48 hrs, 4-day adult  103 Paraquat 5 mM 48 hrs, 4-day adult  (214) Paraquat 10 mM 48 hrs, 4-day adult  (220) Rotenone 2 μg 12 hrs, larvae L3  (815) Rotenone 8 μg 12 hrs, larvae L3  (628) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    107 cold shock, 4-day adult    74 heat shock, 4-day adult    385 Cadmium 50 mM 6 hrs, larvae L3    527 Cadmium 50 mM 12 hrs, larvae L3    596 Cadmium 50 mM 48 hrs, 4-day adult    481 Cadmium 100 mM 48 hrs, 4-day adult    182 Copper 0.5 mM 12 hrs, larvae L3    209 Copper 15 mM 48 hrs, 4-day adult    165 Zinc 5 mM 12 hrs, larvae L3    232 Zinc 4.5 mM 48 hrs, 4-day adult    189 Ethanol 2.5% 3 hrs, larvae L3    190 Ethanol 5% 3 hrs, larvae L3    883 Ethanol 10% 3 hrs, larvae L3    596 Caffeine 1.5 mg/ml 4 hrs, larvae L3    763 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    211 Caffeine 25 mg/ml 48 hrs, 4-day adult    103 Paraquat 5 mM 48 hrs, 4-day adult    214 Paraquat 10 mM 48 hrs, 4-day adult    220 Rotenone 2 μg 12 hrs, larvae L3    815 Rotenone 8 μg 12 hrs, larvae L3    628 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    107 cold shock, 4-day adult    74 heat shock, 4-day adult    385 Cadmium 50 mM 6 hrs, larvae L3    527 Cadmium 50 mM 12 hrs, larvae L3    596 Cadmium 50 mM 48 hrs, 4-day adult    481 Cadmium 100 mM 48 hrs, 4-day adult    182 Copper 0.5 mM 12 hrs, larvae L3    209 Copper 15 mM 48 hrs, 4-day adult    165 Zinc 5 mM 12 hrs, larvae L3    232 Zinc 4.5 mM 48 hrs, 4-day adult    189 Ethanol 2.5% 3 hrs, larvae L3    190 Ethanol 5% 3 hrs, larvae L3    883 Ethanol 10% 3 hrs, larvae L3    596 Caffeine 1.5 mg/ml 4 hrs, larvae L3    763 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    211 Caffeine 25 mg/ml 48 hrs, 4-day adult    103 Paraquat 5 mM 48 hrs, 4-day adult    214 Paraquat 10 mM 48 hrs, 4-day adult    220 Rotenone 2 μg 12 hrs, larvae L3    815 Rotenone 8 μg 12 hrs, larvae L3    628 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (107) cold shock, 4-day adult  (74) heat shock, 4-day adult  (385) Cadmium 50 mM 6 hrs, larvae L3  (527) Cadmium 50 mM 12 hrs, larvae L3  (596) Cadmium 50 mM 48 hrs, 4-day adult  (481) Cadmium 100 mM 48 hrs, 4-day adult  (182) Copper 0.5 mM 12 hrs, larvae L3  (209) Copper 15 mM 48 hrs, 4-day adult  (165) Zinc 5 mM 12 hrs, larvae L3  (232) Zinc 4.5 mM 48 hrs, 4-day adult  (189) Ethanol 2.5% 3 hrs, larvae L3  (190) Ethanol 5% 3 hrs, larvae L3  (883) Ethanol 10% 3 hrs, larvae L3  (596) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (763) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (211) Caffeine 25 mg/ml 48 hrs, 4-day adult  (103) Paraquat 5 mM 48 hrs, 4-day adult  (214) Paraquat 10 mM 48 hrs, 4-day adult  (220) Rotenone 2 μg 12 hrs, larvae L3  (815) Rotenone 8 μg 12 hrs, larvae L3  (628) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  107 cold shock, 4-day adult    74 heat shock, 4-day adult  (385) Cadmium 50 mM 6 hrs, larvae L3  (527) Cadmium 50 mM 12 hrs, larvae L3  (596) Cadmium 50 mM 48 hrs, 4-day adult  (481) Cadmium 100 mM 48 hrs, 4-day adult  (182) Copper 0.5 mM 12 hrs, larvae L3  (209) Copper 15 mM 48 hrs, 4-day adult  (165) Zinc 5 mM 12 hrs, larvae L3  (232) Zinc 4.5 mM 48 hrs, 4-day adult  (189) Ethanol 2.5% 3 hrs, larvae L3  (190) Ethanol 5% 3 hrs, larvae L3  (883) Ethanol 10% 3 hrs, larvae L3  (596) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (763) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (211) Caffeine 25 mg/ml 48 hrs, 4-day adult  103 Paraquat 5 mM 48 hrs, 4-day adult  (214) Paraquat 10 mM 48 hrs, 4-day adult  (220) Rotenone 2 μg 12 hrs, larvae L3  (815) Rotenone 8 μg 12 hrs, larvae L3  (628) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    107 cold shock, 4-day adult    74 heat shock, 4-day adult    385 Cadmium 50 mM 6 hrs, larvae L3    527 Cadmium 50 mM 12 hrs, larvae L3    596 Cadmium 50 mM 48 hrs, 4-day adult    481 Cadmium 100 mM 48 hrs, 4-day adult    182 Copper 0.5 mM 12 hrs, larvae L3    209 Copper 15 mM 48 hrs, 4-day adult    165 Zinc 5 mM 12 hrs, larvae L3    232 Zinc 4.5 mM 48 hrs, 4-day adult    189 Ethanol 2.5% 3 hrs, larvae L3    190 Ethanol 5% 3 hrs, larvae L3    883 Ethanol 10% 3 hrs, larvae L3    596 Caffeine 1.5 mg/ml 4 hrs, larvae L3    763 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    211 Caffeine 25 mg/ml 48 hrs, 4-day adult    103 Paraquat 5 mM 48 hrs, 4-day adult    214 Paraquat 10 mM 48 hrs, 4-day adult    220 Rotenone 2 μg 12 hrs, larvae L3    815 Rotenone 8 μg 12 hrs, larvae L3    628 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040529 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9603-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG9603GD3912 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG9603GD3912 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 CG9603GD3912 trichogen cell, with Scer\GAL4pnr-MD237 CG9603GD3912
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG9603 Class Mutagen Stocks Known lesion CG9603d04921 P-element activity 2 -- CG9603e03209 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG9603 Class Mutagen Stocks Known lesion CG9603GD3912 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG9603KK110870 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)Coq21D (Cheng et al., 2011) Df(3R)Poxm85A (Cheng et al., 2011)
Disrupted in	Df(3R)Exel6148 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3912} NA P{KK110870} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}CG9603e03209 NA insertion of mobile activating element P{XP}CG9603d04921 NA P{XP}d05123d05123 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
cytochrome-c oxidase activity inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) inferred from sequence or structural similarity with UniProtKB:P24310 (Sardiello et al., 2003.6.11) electron carrier activity inferred from electronic annotation with InterPro:IPR003177 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mitochondrial electron transport, cytochrome c to oxygen inferred from sequence or structural similarity with UniProtKB:P24310 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial respiratory chain complex IV inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) inferred from sequence or structural similarity with UniProtKB:P24310 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG9603 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72497 DroID - A comprehensive database of gene and protein interactions. • FBgn0040529 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 50002
Orthologs
OrthoDB Orthologs (21) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PCBCW Dipteran inclusive ortholog search EOG6HQDV0 Insect inclusive ortholog search EOG6FXQ5K Arthropod inclusive ortholog search EOG6TDZ38 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6PCBCW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG9603     Drosophila simulans   Dsim\GD20874 Y   Drosophila sechellia   Dsec\GM26348 Y   Drosophila erecta   Dere\GG17453 Y   Drosophila yakuba   Dyak\GE24854 Y   Drosophila ananassae   Dana\GF16667 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21907 Y   Drosophila persimilis   Dper\GL24117 Y   Drosophila willistoni   Dwil\GK14100 Y   Drosophila virilis   Dvir\GJ22750 Y   Drosophila mojavensis   Dmoj\GI22749 Y   Drosophila grimshawi   Dgri\GH17420 Y
Orthologs in non-Drosophila Dipterans (EOG6HQDV0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007752   Anopheles gambiae Malaria mosquito  Agam\AGAP000109   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015566
Orthologs in non-Dipteran Insects (EOG6FXQ5K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011136 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI48334 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009733 Y Pediculus humanus Human body louse  Phum\PHUM333950 Y Tribolium castaneum Red flour beetle  Tcas\TC015888 Y
Orthologs in non-Insect Arthropods (EOG6TDZ38)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_305858 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20874 Drosophila sechellia Dsec\GM26348 Drosophila erecta Dere\GG17453 Drosophila yakuba Dyak\GE24854 Drosophila ananassae Dana\GF16667 Drosophila pseudoobscura pseudoobscura Dpse\GA21907 Drosophila persimilis Dper\GL24117 Drosophila willistoni Dwil\GK14100 Drosophila virilis Dvir\GJ22750 Drosophila mojavensis Dmoj\GI22749 Drosophila grimshawi Dgri\GH17420
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	19210 w1118; P{XP}CG9603d04921/TM6B, Tb1 18133 w1118; PBac{RB}CG9603e03209/TM6B, Tb1
Harvard	- P{XP}CG9603d04921 - PBac{RB}CG9603e03209
VDRC	v106661 P{KK110870}VIE-260B v37496 w1118; P{GD3912}v37496
Genomic Clones ( 1 )
	BACR33N15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM26747 RE30055
Other clones	MIP15419
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH11242 GH16425 GM26748 LP02592 LP03512 LP04365 LP07720 LP22918 RE04382 RE14026 RE30424 RE30448 RE37206 RE39665 RE42183 RE46289 RE67718 RH28816 RH28976 RH30523 RH37875 RH37884 RH41543 RH47927 RH63456 RH67508 SD19716
Other clones	Dmel_dig_012942_0618_3556 Dmel_dig_013177_0649_3592 Dmel_dig_016181_0645_0490 Dmel_neb_010912_0918_2491 EC14225 EC23866 EC26246 EC30166 EC34466 EC37246 EC38195 EK044401 EK060055 EK125413 EK145029 EK145030 EK193412 EK195909 EK230532 EN16423 EP06555 EP07755 EP07855 FGC008B04 FGC022G12 FGC026F02 FGH103B02 FGH108C09 FGH117B09 FGH119A09 FGH120E10 FGM212F05 FGM215B04 FGM233B09 FGM233G11 IP17290
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040529 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 50002
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143927 NM_001260057 RefSeq (Proteins) • NP_652184 NP_001246986 DDBJ / EMBL / GenBank • AAF54227 AAL48889 AFH06305 AY071267 BI234364 BI234678 CZ480981 Entrez Gene - A searchable database of RefSeq genes. • 50002 UniProtKB/Swiss-Prot • Q9VHS2 UniProtKB/TrEMBL • Q8SYW9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome c oxidase, subunit VIIa (IPR003177) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME09603
Linkouts
	BioGRID - A database of protein and genetic interactions • 72497 DroID - A comprehensive database of gene and protein interactions. • FBgn0040529 DRSC - Results from RNAi screens. • FBgn0040529 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040529 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9603-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040529 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 50002 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 50002 modMine - Data generated by the modENCODE project. • FBgn0040529
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG9603 (Cheng et al., 2011, Porcelli et al., 2007, Tripoli et al., 2005, Kankel et al., 2007, Keleman et al., 2009.8.5, Porcelli et al., 2010, Cammarato et al., 2011) VIIa (Szuplewski and Terracol, 2001)
Name Synonym	Cytochrome c oxidase Polypeptide VIIa (Tripoli et al., 2005) Cytochrome c oxidase Polypeptide VIIA (Tripoli et al., 2005) Cytochrome c oxidase VIIa (Porcelli et al., 2007)
Secondary FlyBase IDs
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...