FlyBase Gene Report: Dmel\COX7A

General Information

Symbol

Dmel\COX7A

Species

D. melanogaster

Name

Cytochrome c oxidase subunit 7A

Annotation Symbol

CG9603

Feature Type

protein_coding_gene

FlyBase ID

FBgn0040529

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (UniProt, Q9VHS2)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

84F13-84F13

Sequence location

3R:8,339,944..8,341,043 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:8339944..8341043

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mitochondrial electron transport, cytochrome c to oxygen

inferred from electronic annotation with InterPro:IPR003177, InterPro:IPR036539

(InterPro Project Members, 2004-)

involved_in mitochondrial respirasome assembly

inferred from biological aspect of ancestor with PANTHER:PTN000828143

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

located_in mitochondrion

inferred from high throughput direct assay

(Tan et al., 2009)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of respiratory chain complex IV

inferred from electronic annotation with InterPro:IPR036539

(InterPro Project Members, 2004-)

non-traceable author statement

(Porcelli et al., 2007)

part_of respiratory chain complex

inferred from biological aspect of ancestor with PANTHER:PTN000828143

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - SUPERNUMERARY SUBUNITS

MITOCHONDRIAL COMPLEX IV

Protein Family (UniProt)

Belongs to the cytochrome c oxidase VIIa family. (Q9VHS2)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - SUPERNUMERARY SUBUNITS -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. Eukaryotic COX is a multimeric enzyme formed by subunits of dual genetic origin. The three subunits forming the catalytic core of the enzyme (COX1, COX2 and COX3) are encoded by the mitochondrial DNA. The non-catalytic subunits are all encoded by the nuclear DNA. The functions of these 'supernumerary subunits' are largely unknown, though are assumed to regulate complex IV activity and to coordinate energy production with cellular needs. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)

Protein Function (UniProtKB)

(UniProt, Q9VHS2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\COX7A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VHS2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0081855

621

FBtr0305680

566

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

COX7A-PA

FBpp0081344

9.9

10.71

FBpp0296960

10.8

10.16

A0A0B4K6C3

NP_001246986

AFH06305

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

(UniProt, Q9VHS2)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\COX7A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG9603_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.38

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

located_in mitochondrion

inferred from high throughput direct assay

(Tan et al., 2009)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\COX7A in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\COX7A

View exonic expression by tissue for Dmel\COX7A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040529

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

50002/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040529

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040529

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040529

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9603

Flygut - An atlas of the Drosophila adult midgut

FBgn0040529

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of COX7A

Transgenic constructs containing regulatory region of COX7A

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene not disrupted in

Df(3R)Coq2^1D

(Cheng et al., 2011)

Df(3R)Poxm^85A

(Cheng et al., 2011)

Gene disrupted in

Df(3R)Exel6148

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(3R)Arl2^Δ156

(Chen et al., 2016)

Df(3R)Arl2^Δ309

(Chen et al., 2016)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during P-stage, with Scer\GAL4^da.PU

COX7A^KK110870

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

COX7A^GD3912

viable, with Scer\GAL4^Mef2.PR

COX7A^GD3912

viable, with Scer\GAL4^pnr-MD237

COX7A^GD3912

viable, with Scer\GAL4^tin.CΔ4

COX7A^GD3912

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage, with Scer\GAL4^ChAT.7.4

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav-C155

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR51B08

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR51C07

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR51C09

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR51G05

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR52A01

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR55A05

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR59E04

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^VGlut1-OK371

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^VT001211

COX7A^KK110870

abnormal locomotor behavior | adult stage, with Scer\GAL4^VT001215

COX7A^KK110870

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

COX7A^GD3912

bang sensitive, with Scer\GAL4^elav-C155

COX7A^KK110870

increased cell death | adult stage, with Scer\GAL4^elav-C155

COX7A^KK110870

short lived | adult stage, with Scer\GAL4^elav-C155

COX7A^KK110870

visible, with Scer\GAL4^pnr-MD237

COX7A^GD3912

Phenotype manifest in

Allele

adult brain, with Scer\GAL4^elav-C155

COX7A^KK110870

mesonotum, with Scer\GAL4^pnr-MD237

COX7A^GD3912

trichogen cell, with Scer\GAL4^pnr-MD237

COX7A^GD3912

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (4)

Hsap\COX7A1

9 of 14

Yes

Hsap\COX7A2

8 of 14

Yes

Hsap\COX7A2L

6 of 14

Hsap\COX7A2P2

6 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Cox7a2

8 of 14

Yes

Rnor\Cox7a1

7 of 14

Rnor\Cox7a2l2

7 of 14

Yes

Rnor\Cox7a2l

6 of 14

Yes

Mus musculus (laboratory mouse) (3)

Mmus\Cox7a2

8 of 14

Yes

Mmus\Cox7a1

7 of 14

Mmus\Cox7a2l

5 of 14

Xenopus tropicalis (Western clawed frog) (4)

Xtro\cox7a2

7 of 13

Yes

Xtro\XB5730115

6 of 13

Yes

Xtro\cox7a2l

2 of 13

Yes

Xtro\cox7a1

1 of 13

Danio rerio (Zebrafish) (4)

Drer\cox7a2a

8 of 14

Yes

Drer\cox7a1

6 of 14

Drer\cox7a2b

6 of 14

Drer\cox7a2l

5 of 14

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP000109

11 of 12

Yes

Agam\AgaP_AGAP009526

4 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:COX7A. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

COX7AL

7 of 13

COX7AL2

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

mitochondrial complex IV dysfunction, general model

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

COX7A^KK110870

model of cytochrome-c oxidase deficiency disease

CEA

(Kemppainen et al., 2014)

COX7A^HMC04889

model of epilepsy

CEA

(Hope et al., 2020)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

COX7A^KK110870

model of cytochrome-c oxidase deficiency disease

is ameliorated by Zzzz\AOX^Scer\UAS.cFa

(Kemppainen et al., 2014)

is ameliorated by Cint\AOX^UAS.cFa

(Kemppainen et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

COX7A1; cytochrome c oxidase subunit 7A1

9 of 14

123995

COX7A2; cytochrome c oxidase subunit 7A2

8 of 14

123996

COX7A2L; cytochrome c oxidase subunit 7A2 like

6 of 14

605771

COX7A2P2; cytochrome c oxidase subunit 7A2 pseudogene 2

6 of 14

123997

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

COX7A - COX4

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - COX5A

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - COX5B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - COX6B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - COX7AL2

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - COX7B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - COX8

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - ND-MLRQ

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - cype

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - levy

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - mt:CoI

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - mt:CoII

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX7A - mt:CoIII

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

RNA-protein

Physical Interaction

Assay

References

COX7A - smg

anti bait coimmunoprecipitation, primer specific pcr

(Chartier et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9VHS2 )

Linkouts

BioGRID - A database of protein and genetic interactions.

72497

DroID - A comprehensive database of gene and protein interactions.

FBgn0040529

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84F13-84F13

Sequence location

3R:8,339,944..8,341,043 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84F13-84F13

Limits computationally determined from genome sequence between P{EP}EP833 and P{lacW}l(3)L4740^L4740

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

19210

w¹¹¹⁸; P{XP}COX7A^d04921/TM6B, Tb¹

18133

w¹¹¹⁸; PBac{RB}COX7A^e03209/TM6B, Tb¹

80487

y¹ sc^* v¹ sev²¹; P{TOE.GS01163}attP40

57572

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04889}attP40

VDRC

v106661

P{KK110870}VIE-260B

v37496

w¹¹¹⁸; P{GD3912}v37496

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (62)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP15419

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0040529

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0040529

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: COX7A CG9603

(Porcelli and Marygold, 2014.9.16)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

COX-7A

(Groen et al., 2022)

COX7A

(Curcio et al., 2024, Müller-Eigner et al., 2024, Adashev et al., 2022, O'Hanlon et al., 2022, Marygold, 2021.2.26, Hope et al., 2020, Yalgin et al., 2020, Transgenic RNAi Project members, 2017-, Chen et al., 2016, Porcelli and Marygold, 2014.9.16)

COX7A1

(Brischigliaro et al., 2022)

COX7a

(Jiang et al., 2022, Sorge et al., 2020)

COXJ

(Caggese et al., 2006)

COXK

(Caggese et al., 2006)

Cox7a

(Kemppainen et al., 2014)

Q9VHS2

(Ebanks et al., 2021)

VIIa

(Szuplewski and Terracol, 2001)

cox7a

(Lam Wong and Verheyen, 2021)

Name Synonyms

Cytochrome c oxidase Polypeptide VIIA

(Tripoli et al., 2005)

Cytochrome c oxidase Polypeptide VIIa

(Tripoli et al., 2005)

Cytochrome c oxidase VIIa

(Porcelli et al., 2007)

Cytochrome c oxidase polypeptide VIIa

(Caggese et al., 2006)

Cytochrome c oxidase subunit 7A

(Porcelli and Marygold, 2014.9.16)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

50002

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VHS2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VHS2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VHS2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040529

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

50002/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040529

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040529

FlyMine - An integrated database for Drosophila genomics

FBgn0040529

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9603

MARRVEL_MODEL - MARRVEL (model organism gene)

50002

Linkouts

BioGRID - A database of protein and genetic interactions.

72497

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0040529

DroID - A comprehensive database of gene and protein interactions.

FBgn0040529

DRSC - Results frm RNAi screens

FBgn0040529

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG9603_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040529

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0040529

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9603

Flygut - An atlas of the Drosophila adult midgut

FBgn0040529

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0040529

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (67)

The following external sites may use different assemblies or annotations than FlyBase.

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