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Gene Dmel\schlank

General Information
Symbol	Dmel\schlank	Species	D. melanogaster
Name	schlank	Annotation symbol	CG3576
Feature type	protein_coding_gene	FlyBase ID	FBgn0040918
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	lag1, Dlag1, l(1)G0061
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	5E3-5E4	Sequence location	X:6,151,701..6,161,261 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene schlank is referred to in FlyBase by the symbol Dmel\schlank (CG3576, FBgn0040918). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: triglyceride metabolic process; negative regulation of lipid catabolic process; positive regulation of lipid biosynthetic process; SREBP signaling pathway; ceramide biosynthetic process. 19 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeodomain; Homeodomain-like; Longevity assurance, LAG1/LAC1; TRAM/LAG1/CLN8 homology domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval Malpighian tubules, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629286_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of schlank. Gene sequence location is X:6151701..6161261.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 5E3-5E4   Limits computationally determined from genome sequence between P{EP}EP1457EP1457&P{EP}CG5928EP1083 and P{EP}EP1311&P{EP}EP1384
Experimentally Determined Cytological Location
Cytogenetic map Notes References 5E1-5E2   (determined by in situ hybridisation)   (Peter et al., 2002) 5E-5E   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.2) 5E1-5E2   (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 5E1-5E2   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 9E3-9E4   (determined by in situ hybridisation)   (Schaefer et al., 1999.3.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\schlank for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) schlank-RA FBtr0070937  NM_167063   2201   400 schlank-RB FBtr0070938  NM_144269   2487   400
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein schlank-PA   FBpp0070898   46.4   400   9.80     NP_727075   AAF46137 schlank-PB   FBpp0070899   46.4   400   9.80     NP_652526   AAG22409
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeodomain (IPR001356) TRAM/LAG1/CLN8 homology domain (IPR006634) Homeodomain-like (IPR009057) Longevity assurance, LAG1/LAC1 (IPR016439)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141370   AA141973   AA539230   AE014298 AAF46137   AE014298 AAG22409   AI388555   AJ426708   AJ426710   AJ426713   AW942505   AY061255 AAL28803   AY066020 AAL57756   AY118702   BH146205   BI163123   BI163161   BI169376   BI241099   BI241773   BI242643   BI242826   BI243314   BI352614   BI358383   BI364242   BI365824   BI367153   BI369708   BI371779   BI371786   BI482934   BI486065   BI579521   BI580564   BI580794   BI592951   BP547246   BP554169   BP554873   BP558183   CO154622   CO156119   CO189452   CO278553   CO281129   CO282295   CO286677   CO297018   CO317327   CO321176   CO324541   CO332963   CO336122   CO343116   CZ471217   CZ483721   EC061135   EC075816   EC080706   EC084622   EC090003   EC206306   EC213810   EC229201   EC229940   EC239815   EC245426   EC256133   EC261670   EC265969   ES692959   ES692987   GH748012   GH750997   GH751002   GH752313   GH752392   GH755440   GH755699   GH755805   GH756864   GH759739   GH760576   GH772090   GH772938   GH773768   GH774627   GH774842   GH775097   GH775326   GH776946   GH777278   GH778396   GH778748   GH780151   GH780302   GH781087   GH783047   GH783211   GH785175   GH785429   GH785924   GH787472   GH787625   GH789496   GH791329   GH792052   GH794131   GH794434   GH795237   GH796297   GH799686   GH802837   GH805646   GH806059   GH807241   GH807493   GH807769   GH808534   GH808903   GH812506   GH812928   GH816838   GH817098   GH819047   GH819332   GH819653   GH821111   GH822876   GH824806   GH824921   GH827390   GH827648   GH827828   GH828615   GH830985   GH831174   GH834657   GH834795   GH834967   GH836005   GH836163   GH840089   GH840374   GH844535   GH846860   GH848278   GH848889   GH851362   GH851621   GH851826   GH852122   GH853202   GH853935   GH854196   GH854436   GH861694   GH868973   GH869958   GH870018   GH870278   GH872393   GH872660   GH873912   GH875379   GH876612   GH877076   GH877247   GH877614   GH878858   GH879059   GH881112   GH881224   GH881650   GH882820   GH883830   GH885222   GH891489   GH894462   GH895081   GH895210   GH897338   GH899249   GH901869   GH901878   GH901891   GH903652   GH907147   GH907352   GH908808   GH910725   GH912945   GH914598   GH915485   GH915756   GH920165   GH920548   GH921294   GH924489   GH924774   GH924962   GH925280   GH925876   GH926215   GH926260   GH926718   GH927384   GH928309   GH931046   GH931184   GH932722   GH934210   GH935316   GH937672
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W423
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval Malpighian tubules, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    560.925 Larval Midgut    504.8 Larval Hindgut    498.2 Larval Malpighian Tubules    526 Larval Fat Body    1046.5 Larval Salivary Gland    243.6 Larval Trachea    285.925 Larval Carcass    254.2 Adult Head    208.2 Adult Eye    187.675 Adult Brain    354.1 Adult Thoracic-Abdominal Ganglion    412.6 Adult Crop    167.5 Adult Midgut    479.1 Adult Hindgut    205.3 Adult Malpighian Tubules    170.5 Adult Fat Body    403.3 Adult Salivary Gland    232.5 Adult Heart    268.3 Adult VirginFemale Spermatheca    256.5 Adult InseminatedFemale Spermatheca    230.3 Adult Ovary    297 Adult Testis    73.6 Adult Male Accessory Gland    182.6 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (560.925) Larval Midgut  504.8 Larval Hindgut    498.2 Larval Malpighian Tubules  526 Larval Fat Body  (1046.5) Larval Salivary Gland    243.6 Larval Trachea    285.925 Larval Carcass    254.2 Adult Head    208.2 Adult Eye    187.675 Adult Brain    354.1 Adult Thoracic-Abdominal Ganglion    412.6 Adult Crop    167.5 Adult Midgut    479.1 Adult Hindgut    205.3 Adult Malpighian Tubules    170.5 Adult Fat Body    403.3 Adult Salivary Gland    232.5 Adult Heart    268.3 Adult VirginFemale Spermatheca    256.5 Adult InseminatedFemale Spermatheca    230.3 Adult Ovary    297 Adult Testis    73.6 Adult Male Accessory Gland    182.6 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    560.925 Larval Midgut    504.8 Larval Hindgut    498.2 Larval Malpighian Tubules    526 Larval Fat Body  1046.5 Larval Salivary Gland    243.6 Larval Trachea    285.925 Larval Carcass    254.2 Adult Head    208.2 Adult Eye    187.675 Adult Brain    354.1 Adult Thoracic-Abdominal Ganglion    412.6 Adult Crop    167.5 Adult Midgut    479.1 Adult Hindgut    205.3 Adult Malpighian Tubules    170.5 Adult Fat Body    403.3 Adult Salivary Gland    232.5 Adult Heart    268.3 Adult VirginFemale Spermatheca    256.5 Adult InseminatedFemale Spermatheca    230.3 Adult Ovary    297 Adult Testis    73.6 Adult Male Accessory Gland    182.6 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    560.925 Larval Midgut    504.8 Larval Hindgut    498.2 Larval Malpighian Tubules    526 Larval Fat Body    1046.5 Larval Salivary Gland    243.6 Larval Trachea    285.925 Larval Carcass    254.2 Adult Head    208.2 Adult Eye    187.675 Adult Brain    354.1 Adult Thoracic-Abdominal Ganglion    412.6 Adult Crop    167.5 Adult Midgut    479.1 Adult Hindgut    205.3 Adult Malpighian Tubules    170.5 Adult Fat Body    403.3 Adult Salivary Gland    232.5 Adult Heart    268.3 Adult VirginFemale Spermatheca    256.5 Adult InseminatedFemale Spermatheca    230.3 Adult Ovary    297 Adult Testis    73.6 Adult Male Accessory Gland    182.6 Adult Carcass    125.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    560.925 Larval Midgut    504.8 Larval Hindgut    498.2 Larval Malpighian Tubules    526 Larval Fat Body    1046.5 Larval Salivary Gland    243.6 Larval Trachea    285.925 Larval Carcass    254.2 Adult Head    208.2 Adult Eye    187.675 Adult Brain    354.1 Adult Thoracic-Abdominal Ganglion    412.6 Adult Crop    167.5 Adult Midgut    479.1 Adult Hindgut    205.3 Adult Malpighian Tubules    170.5 Adult Fat Body    403.3 Adult Salivary Gland    232.5 Adult Heart    268.3 Adult VirginFemale Spermatheca    256.5 Adult InseminatedFemale Spermatheca    230.3 Adult Ovary    297 Adult Testis    73.6 Adult Male Accessory Gland    182.6 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  560.925 Larval Midgut  504.8 Larval Hindgut    498.2 Larval Malpighian Tubules  526 Larval Fat Body  (1046.5) Larval Salivary Gland    243.6 Larval Trachea    285.925 Larval Carcass    254.2 Adult Head    208.2 Adult Eye    187.675 Adult Brain    354.1 Adult Thoracic-Abdominal Ganglion    412.6 Adult Crop    167.5 Adult Midgut    479.1 Adult Hindgut    205.3 Adult Malpighian Tubules    170.5 Adult Fat Body    403.3 Adult Salivary Gland    232.5 Adult Heart    268.3 Adult VirginFemale Spermatheca    256.5 Adult InseminatedFemale Spermatheca    230.3 Adult Ovary    297 Adult Testis    73.6 Adult Male Accessory Gland    182.6 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    560.925 Larval Midgut    504.8 Larval Hindgut    498.2 Larval Malpighian Tubules    526 Larval Fat Body  1046.5 Larval Salivary Gland    243.6 Larval Trachea    285.925 Larval Carcass    254.2 Adult Head    208.2 Adult Eye    187.675 Adult Brain    354.1 Adult Thoracic-Abdominal Ganglion    412.6 Adult Crop    167.5 Adult Midgut    479.1 Adult Hindgut    205.3 Adult Malpighian Tubules    170.5 Adult Fat Body    403.3 Adult Salivary Gland    232.5 Adult Heart    268.3 Adult VirginFemale Spermatheca    256.5 Adult InseminatedFemale Spermatheca    230.3 Adult Ovary    297 Adult Testis    73.6 Adult Male Accessory Gland    182.6 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    560.925 Larval Midgut    504.8 Larval Hindgut    498.2 Larval Malpighian Tubules    526 Larval Fat Body    1046.5 Larval Salivary Gland    243.6 Larval Trachea    285.925 Larval Carcass    254.2 Adult Head    208.2 Adult Eye    187.675 Adult Brain    354.1 Adult Thoracic-Abdominal Ganglion    412.6 Adult Crop    167.5 Adult Midgut    479.1 Adult Hindgut    205.3 Adult Malpighian Tubules    170.5 Adult Fat Body    403.3 Adult Salivary Gland    232.5 Adult Heart    268.3 Adult VirginFemale Spermatheca    256.5 Adult InseminatedFemale Spermatheca    230.3 Adult Ovary    297 Adult Testis    73.6 Adult Male Accessory Gland    182.6 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    208.2   NA  Eye    187.675   NA  Brain    354.1   560.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    412.6   NA  Crop    167.5   504.8  Midgut    479.1   498.2  Hindgut    205.3   526  Malpighian Tubules    170.5   1046.5  Fat Body    403.3   243.6  Salivary Gland    232.5   NA  Heart    268.3   285.925  Trachea    NA   NA  VirginFemale Spermatheca    256.5   NA  InseminatedFemale Spermatheca    230.3   NA  Ovary    297   NA  Testis    73.6   NA  Male Accessory Gland    182.6   254.2  Carcass    125.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    51 central nervous system, pupae P8    44 head, virgin 1-day female    25 head, virgin 4-day female    16 head, virgin 20-day female    10 head, mated 1-day female    18 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    50 digestive system, 4-day adult    55 digestive system, 20-day adult    40 fat body, larvae L3 wandering    106 fat body, white prepupae    113 fat body, pupae P8    36 carcass, larvae L3 wandering    27 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    76 ovary, mated 4-day female    83 testis, mated 4-day male    24 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (28) central nervous system, larvae L3  (51) central nervous system, pupae P8  (44) head, virgin 1-day female    25 head, virgin 4-day female    16 head, virgin 20-day female    10 head, mated 1-day female    18 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male  26 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae  (55) digestive system, larvae L3 wandering  (57) digestive system, 1-day adult  (50) digestive system, 4-day adult  (55) digestive system, 20-day adult  (40) fat body, larvae L3 wandering  (106) fat body, white prepupae  (113) fat body, pupae P8  (36) carcass, larvae L3 wandering  (27) carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female  (76) ovary, mated 4-day female  (83) testis, mated 4-day male    24 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    51 central nervous system, pupae P8    44 head, virgin 1-day female    25 head, virgin 4-day female    16 head, virgin 20-day female    10 head, mated 1-day female    18 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    50 digestive system, 4-day adult    55 digestive system, 20-day adult    40 fat body, larvae L3 wandering  106 fat body, white prepupae  (113) fat body, pupae P8    36 carcass, larvae L3 wandering    27 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    76 ovary, mated 4-day female    83 testis, mated 4-day male    24 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    51 central nervous system, pupae P8    44 head, virgin 1-day female    25 head, virgin 4-day female    16 head, virgin 20-day female    10 head, mated 1-day female    18 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    50 digestive system, 4-day adult    55 digestive system, 20-day adult    40 fat body, larvae L3 wandering    106 fat body, white prepupae    113 fat body, pupae P8    36 carcass, larvae L3 wandering    27 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    76 ovary, mated 4-day female    83 testis, mated 4-day male    24 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    51 central nervous system, pupae P8    44 head, virgin 1-day female    25 head, virgin 4-day female    16 head, virgin 20-day female    10 head, mated 1-day female    18 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    50 digestive system, 4-day adult    55 digestive system, 20-day adult    40 fat body, larvae L3 wandering    106 fat body, white prepupae    113 fat body, pupae P8    36 carcass, larvae L3 wandering    27 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    76 ovary, mated 4-day female    83 testis, mated 4-day male    24 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  28 central nervous system, larvae L3  (51) central nervous system, pupae P8  (44) head, virgin 1-day female    25 head, virgin 4-day female    16 head, virgin 20-day female    10 head, mated 1-day female    18 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male  26 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae  (55) digestive system, larvae L3 wandering  (57) digestive system, 1-day adult  (50) digestive system, 4-day adult  (55) digestive system, 20-day adult  (40) fat body, larvae L3 wandering  (106) fat body, white prepupae  (113) fat body, pupae P8  (36) carcass, larvae L3 wandering  27 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female  (76) ovary, mated 4-day female  (83) testis, mated 4-day male    24 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    51 central nervous system, pupae P8    44 head, virgin 1-day female    25 head, virgin 4-day female    16 head, virgin 20-day female    10 head, mated 1-day female    18 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    50 digestive system, 4-day adult    55 digestive system, 20-day adult    40 fat body, larvae L3 wandering  106 fat body, white prepupae  113 fat body, pupae P8    36 carcass, larvae L3 wandering    27 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    76 ovary, mated 4-day female    83 testis, mated 4-day male    24 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    51 central nervous system, pupae P8    44 head, virgin 1-day female    25 head, virgin 4-day female    16 head, virgin 20-day female    10 head, mated 1-day female    18 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    50 digestive system, 4-day adult    55 digestive system, 20-day adult    40 fat body, larvae L3 wandering    106 fat body, white prepupae    113 fat body, pupae P8    36 carcass, larvae L3 wandering    27 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    76 ovary, mated 4-day female    83 testis, mated 4-day male    24 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    15 embryo 04-06hr    33 embryo 06-08hr    41 embryo 08-10hr    51 embryo 10-12hr    81 embryo 12-14hr    56 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    50 embryo 20-22hr    54 embryo 22-24hr    60 larva L1    52 larva L2    44 larva L3 12hr old    37 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    60 white prepupae new    60 white prepupae 12hr    31 white prepupae 24hr    24 pupae 2d postWPP    27 pupae 3d postWPP    35 pupae 4d postWPP    22 adult male 01day    23 adult male 05day    20 adult male 30day    18 adult female 01day    35 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (55) embryo 02-04hr    15 embryo 04-06hr  (33) embryo 06-08hr  (41) embryo 08-10hr  (51) embryo 10-12hr  (81) embryo 12-14hr  (56) embryo 14-16hr  (48) embryo 16-18hr  (42) embryo 18-20hr  (50) embryo 20-22hr  (54) embryo 22-24hr  (60) larva L1  (52) larva L2  (44) larva L3 12hr old  (37) larva L3 puffstage 1-2  (35) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (60) white prepupae new  (60) white prepupae 12hr  (31) white prepupae 24hr    24 pupae 2d postWPP  (27) pupae 3d postWPP  (35) pupae 4d postWPP    22 adult male 01day    23 adult male 05day    20 adult male 30day    18 adult female 01day  (35) adult female 05day  (51) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    15 embryo 04-06hr    33 embryo 06-08hr    41 embryo 08-10hr    51 embryo 10-12hr    81 embryo 12-14hr    56 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    50 embryo 20-22hr    54 embryo 22-24hr    60 larva L1    52 larva L2    44 larva L3 12hr old    37 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    60 white prepupae new    60 white prepupae 12hr    31 white prepupae 24hr    24 pupae 2d postWPP    27 pupae 3d postWPP    35 pupae 4d postWPP    22 adult male 01day    23 adult male 05day    20 adult male 30day    18 adult female 01day    35 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    15 embryo 04-06hr    33 embryo 06-08hr    41 embryo 08-10hr    51 embryo 10-12hr    81 embryo 12-14hr    56 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    50 embryo 20-22hr    54 embryo 22-24hr    60 larva L1    52 larva L2    44 larva L3 12hr old    37 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    60 white prepupae new    60 white prepupae 12hr    31 white prepupae 24hr    24 pupae 2d postWPP    27 pupae 3d postWPP    35 pupae 4d postWPP    22 adult male 01day    23 adult male 05day    20 adult male 30day    18 adult female 01day    35 adult female 05day    51 adult female 30day    50 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    15 embryo 04-06hr    33 embryo 06-08hr    41 embryo 08-10hr    51 embryo 10-12hr    81 embryo 12-14hr    56 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    50 embryo 20-22hr    54 embryo 22-24hr    60 larva L1    52 larva L2    44 larva L3 12hr old    37 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    60 white prepupae new    60 white prepupae 12hr    31 white prepupae 24hr    24 pupae 2d postWPP    27 pupae 3d postWPP    35 pupae 4d postWPP    22 adult male 01day    23 adult male 05day    20 adult male 30day    18 adult female 01day    35 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (55) embryo 02-04hr    15 embryo 04-06hr  (33) embryo 06-08hr  (41) embryo 08-10hr  (51) embryo 10-12hr  (81) embryo 12-14hr  (56) embryo 14-16hr  (48) embryo 16-18hr  (42) embryo 18-20hr  (50) embryo 20-22hr  (54) embryo 22-24hr  (60) larva L1  (52) larva L2  (44) larva L3 12hr old  (37) larva L3 puffstage 1-2  (35) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (60) white prepupae new  (60) white prepupae 12hr  31 white prepupae 24hr    24 pupae 2d postWPP  27 pupae 3d postWPP  (35) pupae 4d postWPP    22 adult male 01day    23 adult male 05day    20 adult male 30day    18 adult female 01day  (35) adult female 05day  (51) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    15 embryo 04-06hr    33 embryo 06-08hr    41 embryo 08-10hr    51 embryo 10-12hr    81 embryo 12-14hr    56 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    50 embryo 20-22hr    54 embryo 22-24hr    60 larva L1    52 larva L2    44 larva L3 12hr old    37 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    60 white prepupae new    60 white prepupae 12hr    31 white prepupae 24hr    24 pupae 2d postWPP    27 pupae 3d postWPP    35 pupae 4d postWPP    22 adult male 01day    23 adult male 05day    20 adult male 30day    18 adult female 01day    35 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    15 embryo 04-06hr    33 embryo 06-08hr    41 embryo 08-10hr    51 embryo 10-12hr    81 embryo 12-14hr    56 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    50 embryo 20-22hr    54 embryo 22-24hr    60 larva L1    52 larva L2    44 larva L3 12hr old    37 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    60 white prepupae new    60 white prepupae 12hr    31 white prepupae 24hr    24 pupae 2d postWPP    27 pupae 3d postWPP    35 pupae 4d postWPP    22 adult male 01day    23 adult male 05day    20 adult male 30day    18 adult female 01day    35 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    146 embryonic 1182-4H    80 embryonic GM2    182 embryonic Kc167    91 embryonic S1    38 embryonic S3    81 leg disc CME L1    117 wing disc CME-W2    145 wing disc ML-DmD8    47 wing disc ML-DmD9    58 wing disc ML-DmD16-c3    65 wing disc ML-DmD21    55 wing disc ML-DmD32    103 haltere disc ML-DmD17-c3    87 eye-antennal disc ML-DmD11    113 antennal disc ML-DmD20-c5    110 mixed discs ML-DmD4-c1    83 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    86 ovary fGS/OSS    30 ovary OSC    70 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (38) Schneider line 2 Sg4  (146) embryonic 1182-4H  (80) embryonic GM2  (182) embryonic Kc167  (91) embryonic S1  (38) embryonic S3  (81) leg disc CME L1  (117) wing disc CME-W2  (145) wing disc ML-DmD8  (47) wing disc ML-DmD9  (58) wing disc ML-DmD16-c3  (65) wing disc ML-DmD21  (55) wing disc ML-DmD32  (103) haltere disc ML-DmD17-c3  (87) eye-antennal disc ML-DmD11  (113) antennal disc ML-DmD20-c5  (110) mixed discs ML-DmD4-c1  (83) CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2  (50) tumorous blood cells mbn2  (86) ovary fGS/OSS  (30) ovary OSC  (70) ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4  (146) embryonic 1182-4H    80 embryonic GM2  (182) embryonic Kc167    91 embryonic S1    38 embryonic S3    81 leg disc CME L1  (117) wing disc CME-W2  (145) wing disc ML-DmD8    47 wing disc ML-DmD9    58 wing disc ML-DmD16-c3    65 wing disc ML-DmD21    55 wing disc ML-DmD32  103 haltere disc ML-DmD17-c3    87 eye-antennal disc ML-DmD11  (113) antennal disc ML-DmD20-c5  (110) mixed discs ML-DmD4-c1    83 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    86 ovary fGS/OSS    30 ovary OSC    70 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    146 embryonic 1182-4H    80 embryonic GM2    182 embryonic Kc167    91 embryonic S1    38 embryonic S3    81 leg disc CME L1    117 wing disc CME-W2    145 wing disc ML-DmD8    47 wing disc ML-DmD9    58 wing disc ML-DmD16-c3    65 wing disc ML-DmD21    55 wing disc ML-DmD32    103 haltere disc ML-DmD17-c3    87 eye-antennal disc ML-DmD11    113 antennal disc ML-DmD20-c5    110 mixed discs ML-DmD4-c1    83 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    86 ovary fGS/OSS    30 ovary OSC    70 ovary OSS    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    146 embryonic 1182-4H    80 embryonic GM2    182 embryonic Kc167    91 embryonic S1    38 embryonic S3    81 leg disc CME L1    117 wing disc CME-W2    145 wing disc ML-DmD8    47 wing disc ML-DmD9    58 wing disc ML-DmD16-c3    65 wing disc ML-DmD21    55 wing disc ML-DmD32    103 haltere disc ML-DmD17-c3    87 eye-antennal disc ML-DmD11    113 antennal disc ML-DmD20-c5    110 mixed discs ML-DmD4-c1    83 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    86 ovary fGS/OSS    30 ovary OSC    70 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (38) Schneider line 2 Sg4  (146) embryonic 1182-4H  (80) embryonic GM2  (182) embryonic Kc167  (91) embryonic S1  (38) embryonic S3  (81) leg disc CME L1  (117) wing disc CME-W2  (145) wing disc ML-DmD8  (47) wing disc ML-DmD9  (58) wing disc ML-DmD16-c3  (65) wing disc ML-DmD21  (55) wing disc ML-DmD32  (103) haltere disc ML-DmD17-c3  (87) eye-antennal disc ML-DmD11  (113) antennal disc ML-DmD20-c5  (110) mixed discs ML-DmD4-c1  (83) CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2  (50) tumorous blood cells mbn2  (86) ovary fGS/OSS  30 ovary OSC  (70) ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4  (146) embryonic 1182-4H    80 embryonic GM2  (182) embryonic Kc167    91 embryonic S1    38 embryonic S3    81 leg disc CME L1  117 wing disc CME-W2  (145) wing disc ML-DmD8    47 wing disc ML-DmD9    58 wing disc ML-DmD16-c3    65 wing disc ML-DmD21    55 wing disc ML-DmD32  103 haltere disc ML-DmD17-c3    87 eye-antennal disc ML-DmD11  113 antennal disc ML-DmD20-c5  110 mixed discs ML-DmD4-c1    83 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    86 ovary fGS/OSS    30 ovary OSC    70 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    146 embryonic 1182-4H    80 embryonic GM2    182 embryonic Kc167    91 embryonic S1    38 embryonic S3    81 leg disc CME L1    117 wing disc CME-W2    145 wing disc ML-DmD8    47 wing disc ML-DmD9    58 wing disc ML-DmD16-c3    65 wing disc ML-DmD21    55 wing disc ML-DmD32    103 haltere disc ML-DmD17-c3    87 eye-antennal disc ML-DmD11    113 antennal disc ML-DmD20-c5    110 mixed discs ML-DmD4-c1    83 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    86 ovary fGS/OSS    30 ovary OSC    70 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    26 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    51 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    65 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (42) cold shock, 4-day adult  26 heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3  (32) Cadmium 50 mM 12 hrs, larvae L3  (51) Cadmium 50 mM 48 hrs, 4-day adult  (42) Cadmium 100 mM 48 hrs, 4-day adult  (55) Copper 0.5 mM 12 hrs, larvae L3  (40) Copper 15 mM 48 hrs, 4-day adult  (65) Zinc 5 mM 12 hrs, larvae L3  (27) Zinc 4.5 mM 48 hrs, 4-day adult  (42) Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3  (38) Ethanol 10% 3 hrs, larvae L3  (28) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (32) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (59) Caffeine 25 mg/ml 48 hrs, 4-day adult  (40) Paraquat 5 mM 48 hrs, 4-day adult  (47) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3  (48) Rotenone 8 μg 12 hrs, larvae L3  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    26 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    51 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    65 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    26 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    51 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    65 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    26 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    51 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    65 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (42) cold shock, 4-day adult  26 heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3  32 Cadmium 50 mM 12 hrs, larvae L3  (51) Cadmium 50 mM 48 hrs, 4-day adult  (42) Cadmium 100 mM 48 hrs, 4-day adult  (55) Copper 0.5 mM 12 hrs, larvae L3  (40) Copper 15 mM 48 hrs, 4-day adult  (65) Zinc 5 mM 12 hrs, larvae L3  27 Zinc 4.5 mM 48 hrs, 4-day adult  (42) Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3  (38) Ethanol 10% 3 hrs, larvae L3  28 Caffeine 1.5 mg/ml 4 hrs, larvae L3  32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (59) Caffeine 25 mg/ml 48 hrs, 4-day adult  (40) Paraquat 5 mM 48 hrs, 4-day adult  (47) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3  (48) Rotenone 8 μg 12 hrs, larvae L3  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    26 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    51 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    65 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    26 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    51 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    65 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_09 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD18904 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040918 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3576-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal schlankG0061 lethal | larval stage schlankG0163 schlankG0349 schlankG0365 schlankG0370 schlankG0489 lethal | pharate adult stage schlankG0061 lethal | recessive schlankG0061 schlankG0365 schlankG0489 viable, with Scer\GAL4pnr-MD237 schlankGD4653 schlankGD15550 Sterility Allele female sterile germline-dependent | germline clone schlankG0349 Other Phenotypes Allele developmental rate defective | larval stage schlankG0061 schlankG0349 developmental rate defective | larval stage, with Scer\GAL4da.G32 schlankdsRNA.Scer\UAS small body | larval stage schlankG0061 schlankG0163 schlankG0349 schlankG0370 small body | larval stage, with Scer\GAL4da.G32 schlankdsRNA.Scer\UAS visible, with Scer\GAL4pnr-MD237 schlankGD4653 schlankGD15550 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 schlankGD4653 schlankGD15550
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of schlank Class Mutagen Stocks Known lesion schlankG0365 P-element activity 2 -- schlankG0489 P-element activity 2 -- schlankc07069 piggyBac transposase 1 -- schlankc07069a 1 -- schlankG0061 P-element activity 1 -- schlankNP7130 1 -- schlankBG02869 P-element activity 0 -- schlankCB-0267-3 0 -- schlankf01245 piggyBac transposase 0 -- schlankG0163 P-element activity 0 -- schlankG0349 P-element activity 0 -- schlankG0370 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of schlank Class Mutagen Stocks Known lesion schlankGD15550 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes schlankGD4653 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes schlankJF02502 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes schlankdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes schlankH215D.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 -- schlankKK108152 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes schlankScer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)BSC640 (Christensen et al., 2008.10.20) Df(1)Exel6238 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK108152} NA P{UAS-schlank.H215D} NA P{UAS-schlank.HA} NA P{UAS-schlank.RNAi} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}schlankBG02869 NA P{RS3}schlankCB-0267-3 NA PBac{PB}schlankc07069 NA PBac{PB}schlankc07069a NA PBac{WH}schlankf01245 NA insertion of enhancer trap binary system P{GawB}schlankNP7130 No insertion of enhancer trap P{lacW}schlankG0061 No P{lacW}schlankG0163 No P{lacW}schlankG0349 No P{lacW}schlankG0365 No P{lacW}schlankG0370 No P{lacW}schlankG0489 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
ceramide biosynthetic process inferred from mutant phenotype (Bauer et al., 2009) negative regulation of lipid catabolic process inferred from mutant phenotype (Bauer et al., 2009) positive regulation of lipid biosynthetic process inferred from mutant phenotype (Bauer et al., 2009) SREBP signaling pathway inferred from mutant phenotype (Bauer et al., 2009) triglyceride metabolic process inferred from mutant phenotype (Bauer et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR001356 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR006634, InterPro:IPR016439 (FlyBase Curators et al., 2004-) plasma membrane inferred from sequence or structural similarity with Saccharomyces LAG1 (Bauer et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
schlank - CG12121 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) schlank - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) schlank - CG5705 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) schlank - CG8195 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) schlank - M6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) schlank - Surf4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) schlank - l(1)G0230 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions schlank allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72669 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0040918 DroID - A comprehensive database of gene and protein interactions. • FBgn0040918 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 50392
Orthologs
OrthoDB Orthologs (71) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6P5KW2 Dipteran inclusive ortholog search EOG69CQH8 Insect inclusive ortholog search EOG69ZWJT Arthropod inclusive ortholog search EOG6XWDD9 Metazoa inclusive ortholog search EOG67Q911
Orthologs in Drosophila Species (EOG6P5KW2)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\schlank     Drosophila sechellia   Dsec\GM12585 Y   Drosophila erecta   Dere\GG17686 Y   Drosophila yakuba   Dyak\GE16474 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17532 Y   Drosophila persimilis   Dper\GL21353 Y   Drosophila willistoni   Dwil\GK25340 Y   Drosophila virilis   Dvir\GJ16002 Y   Drosophila mojavensis   Dmoj\GI21529 Y   Drosophila grimshawi   Dgri\GH24802 Y
Orthologs in non-Drosophila Dipterans (EOG69CQH8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009092   Anopheles gambiae Malaria mosquito  Agam\AGAP001761   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012963
Orthologs in non-Dipteran Insects (EOG69ZWJT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51429   Apis mellifera Western honey bee  Amel\GB46820   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001060   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11607   Atta cephalotes Leafcutter ant  Acep\ACEP13178   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17193   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23405   Linepithema humile Argentine ant  Lhum\LH25045   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21578   Solenopsis invicta Red fire ant  Sinv\SINV24013   Solenopsis invicta Red fire ant  Sinv\SINV20227   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008958   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005492   Bombyx mori Silkmoth  Bmor\BGIBMGA012811   Pediculus humanus Human body louse  Phum\PHUM115780   Tribolium castaneum Red flour beetle  Tcas\TC006052   Tribolium castaneum Red flour beetle  Tcas\TC006053
Orthologs in non-Insect Arthropods (EOG6XWDD9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_220106   Daphnia pulex Water flea  Dpux\COI   Daphnia pulex Water flea  Dpux\JGI_V11_309267   Ixodes scapularis Deer tick  Isca\ISCW005009   Ixodes scapularis Deer tick  Isca\ISCW018120   Ixodes scapularis Deer tick  Isca\ISCW018121
Orthologs in non-Arthropod Metazoa (EOG67Q911)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\hyl-1   Caenorhabditis elegans Nematode  Cele\hyl-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000948gn   Danio rerio Zebrafish  Drer\ENSDARG00000018619   Danio rerio Zebrafish  Drer\lass2   Danio rerio Zebrafish  Drer\ENSDARG00000053583   Danio rerio Zebrafish  Drer\zgc:171494   Danio rerio Zebrafish  Drer\ENSDARG00000058992   Danio rerio Zebrafish  Drer\CABZ01067609.1   Danio rerio Zebrafish  Drer\DKEY-222F2.4   Danio rerio Zebrafish  Drer\trh1   Xenopus tropicalis Western clawed frog  Xtro\cers3   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000013344   Xenopus tropicalis Western clawed frog  Xtro\cers6   Xenopus tropicalis Western clawed frog  Xtro\cers2   Gallus gallus Domestic chicken  Ggal\LOC415513   Gallus gallus Domestic chicken  Ggal\ENSGALG00000006184   Gallus gallus Domestic chicken  Ggal\LASS4   Gallus gallus Domestic chicken  Ggal\LASS6   Gallus gallus Domestic chicken  Ggal\LASS4   Mus musculus House mouse  Mmus\Lass2   Mus musculus House mouse  Mmus\Lass6   Mus musculus House mouse  Mmus\Lass5   Mus musculus House mouse  Mmus\Lass3   Rattus norvegicus Norway rat  Rnor\Cers2   Rattus norvegicus Norway rat  Rnor\Cers5   Rattus norvegicus Norway rat  Rnor\Cers6   Rattus norvegicus Norway rat  Rnor\Cers3   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038982   Rattus norvegicus Norway rat  Rnor\Cers4   Homo sapiens Human  Hsap\CERS6   Homo sapiens Human  Hsap\CERS3   Homo sapiens Human  Hsap\CERS5   Homo sapiens Human  Hsap\CERS2   Homo sapiens Human  Hsap\CERS4
Human Orthologs (5)
Gene OMIM HGNC Hsap\CERS6     Hsap\CERS3     Hsap\CERS5     Hsap\CERS2     Hsap\CERS4
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16201 Drosophila sechellia Dsec\GM12585 Drosophila erecta Dere\GG17686 Drosophila yakuba Dyak\GE16474 Drosophila pseudoobscura pseudoobscura Dpse\GA17532 Drosophila persimilis Dper\GL21353 Drosophila willistoni Dwil\GK25340 Drosophila virilis Dvir\GJ16002 Drosophila mojavensis Dmoj\GI21529 Drosophila grimshawi Dgri\GH24802
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	29340 y1 v1; P{TRiP.JF02502}attP2 11985 w67c23 P{lacW}schlankG0365/FM7c 12276 w67c23 P{lacW}schlankG0489/FM7c 11665 w67c23 P{lacW}schlankG0061 schlankG0061/FM7c
Harvard	- PBac{PB}schlankc07069, PBac{PB}schlankc07069a, PBac{PB}CG1399c07069b
Kyoto	105376 y* w* P{GawB}schlankNP7130 / FM7c 111878 w67c23 P{lacW}schlankG0365 P{neoFRT}19A/FM7c; P{ey-FLP.N}5 111936 y1 w* P{lacW}schlankG0489 P{neoFRT}19A/FM7c; P{ey-FLP.N}5
VDRC	v41114 w1118; P{GD4653}v41114 v33896 w1118; P{GD15550}v33896 v33897 w1118; P{GD15550}v33897
Genomic Clones ( 2 )
	BACR19D03 BACR22D21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 204 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT20865 LD18904
Other clones	DPiM_LD18904
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH19503 GM20060 RE02448 RE02494 RE10533 RE38114 RE38936 RE40039 RE40261 RE40912 RE45127 RE49312 RE51212 RE52856 RE55976 RE58759 RE58771 RE65744 RE69437 RE73567 RE74774 RE75029 RH10783
Other clones	17696 37895 44529 82375 104605 177378 214405.70 280663 557028 572736 CK01.15B.C6 CK01.23C.G5 CK01.54D.F11 CK01.60C.B10 CK00069 CK01638 EK044324 EK063539 EK130350 EK156030 EK160149 EK194137 EK215740 EK267703 EK290440 EK305247 EN04501 EN07361 EN11862 EP16130 FGH114H12 FGM228D06 FGM232B10 FGM313E04 RC0-DE0001-140700-011-A09 RC0-DE0001-140700-011-F10 RP003006869 RP003008134 RP003013209 RP003018135 RP003029780 RP003030257 RP003040015 RP003041103 RP003048649 RP003049395 RP003052123 RP003054102 RP003055669 RP003067170 RP003068721 RP003074677 RP003081160 RP003085539 RP003104259 RP003107003 RP003107201 RP003115792 RP003119421 RP003119725 RP003129317 RP003133116 RP003139798 RP003142516 RP003143986 RP003144294 RP003147960 RP003149814 RP003155920 RP003174936 RP003176519 RP003184639 RP003195470 RP003203202 RP003204549 RP003211015 RP003212366 RP003213663 RP003221183 RP003224269 RP003224679 RP003228722 RP003229370 RP003229660 RP003234849 RP003239786 RP003240505 RP003242597 RP003246794 RP003250522 RP003256276 RP003261405 RP003262961 RP003263080 RP003265387 RP003268151 RP003286672 RP003287897 RP003291061 RP003294752 RP003297044 RP003300646 RP003300680 RP003308164 RP003308992 RP003315392 RP003323748 RP003324566 RP003326221 RP003326893 RP003327828 RP003332376 RP003334871 RP003336417 RP003346408 RP003350581 RP003354777 RP003355326 RP003356855 RP003359197 RP003360231 RP003362372 RP003365734 RP003367062 RP003378215 RP003378986 RP003379115 RP003384040 RP003389691 RP003390835 RP003398386 RP003405047 RP003408773 RP003416703 RP003420483 RP003420503 RP003425871 RP003435332 RP003437222 RP003437862 RP003440615 RP003441370 RP003450073 RP003451522 RP003452004 RP003459030 RP003466923 RP003472672 RP003474189 RP003476286 RP003493998 RP003500234 RP003501906 RP003502108 RP003502253 RP003509822 RP003519310 RP003525062 RP003528712 RP003533304 RP003537120 RP003542240 RP003558590 RP003558921 RP003563185 RP003579977 RP003587510 RP003588682 RP003624547 RP003634165 RP003635351 RP003636808 RP003639345 RP003641453 RP003643906 RP003659225 RP003665551 RP003668029
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040918 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 50392
Antibody Information
	polyclonal (Bauer et al., 2009, Voelzmann and Bauer, 2011)
Other Information
Discoverer
Etymology
	'schlank' means 'slim' in German - named as such because mutants show defects in larval growth and fat metabolism. (Bauer et al., 2009)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Lag1 CG15898 (Bauer, 2002.3.22)
Source for database merge of	Source for merge of: CG15898 CG3576 (FlyBase, 1996-) Source for merge of: Lag1 l(1)G0365 l(1)G0061 l(1)G0489 (Peter et al., 2002)
Additional comments	Source for merge of CG15898 CG3576 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	Lag1 mutant show homozygous embryonic lethality, with ventral holes and germband extension/retraction problems. (Bauer et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_144269 NM_167063 RefSeq (Proteins) • NP_652526 NP_727075 DDBJ / EMBL / GenBank • AA539230 AAF46137 AAG22409 AAL28803 AAL57756 AJ426708 AJ426710 AJ426713 AW942505 AY061255 AY066020 BH146205 CZ471217 CZ483721 Entrez Gene - A searchable database of RefSeq genes. • 50392 UniProtKB/TrEMBL • Q9W423
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeodomain (IPR001356) TRAM/LAG1/CLN8 homology domain (IPR006634) Homeodomain-like (IPR009057) Longevity assurance, LAG1/LAC1 (IPR016439) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD18904
Linkouts
	BioGRID - A database of protein and genetic interactions • 72669 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0040918 DroID - A comprehensive database of gene and protein interactions. • FBgn0040918 DRSC - Results from RNAi screens. • FBgn0040918 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040918 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3576-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040918 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 50392 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 50392 modMine - Data generated by the modENCODE project. • FBgn0040918
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG3576 (Peter et al., 2002, Ida et al., 2009, Perkins et al., 2009, Keleman et al., 2009.8.5) CG15898   Dlag1 (Bauer et al., 2005) DLAG1 (Bauer et al., 2002) DLag1 (Bauer et al., 2009) l(1)G0061 (Schaefer et al., 1999.6.15, Schaefer et al., 1999.3.29, ) l(1)G0365 (Schaefer et al., 1999.8.12, ) l(1)G0489 (Schaefer et al., 1999.12.2, ) lag1 (Kuronen et al., 2009) Lag1 (Christensen et al., 2008.10.20, Ida et al., 2009, Bhutkar et al., 2007, Manning et al., 2012) lon (Bauer, 2001.12.10) schlank (Bauer et al., 2009, Wasbrough et al., 2010)
Name Synonym	longevity (Bauer, 2001.12.10) Longevity assurance gene 1   Psc (Bauer et al., 2009) schlank (Voelzmann and Bauer, 2011, )
Secondary FlyBase IDs
	FBgn0026692 FBgn0028312 FBgn0029852 FBgn0040141
References ( 34 )
Generate a list of	All references relating to this gene ( 34 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 2 )
	Manning et al., 2012, Cell Rep. 2(4): 1002--1013 A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. [FBrf0219785] Voelzmann and Bauer, 2011, Gene Expr. Patterns 11(8): 501--510 Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS. [FBrf0216467] Show all research papers ...