wun-2, Tunen, N14, Pap2G
lipid phosphate phosphohydrolases - somatic Wun and Wun2 provide a repulsive environment for germ cell migration by depleting an extracellular, attractive substrate - in germ cells Wun2 competes with somatic Wun and Wun2 for a common lipid phosphate substrate, which is required by germ cells to produce a survival signal
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wun2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\wun2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Tunen CG8805
Source for merge of: wun2 Tunen
Source for merge of: Tunen BEST:CK02248
Source for merge of: wun2 Pap2G
Source for merge of: wun2 N14
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Identification: genetic screen for mutants affecting pole cell development.
Embryos lacking maternal wun2 function form normal number of pole cells. However, most of these pole cells are lost during their migration to the gonads, and no or few pole cells are incorporated into the gonads. No defect is observed in somatic cell development, and the mutant embryos develop into sterile adults.
Identification: in an over-expression screen for genes which effect germ cell migration.
Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.