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Gene Dmel\scyl

General Information
Symbol	Dmel\scyl	Species	D. melanogaster
Name	scylla	Annotation symbol	CG7590
Feature type	protein_coding_gene	FlyBase ID	FBgn0041094
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	68B4-68C1	Sequence location	3L:11,245,410..11,248,343 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene scylla is referred to in FlyBase by the symbol Dmel\scyl (CG7590, FBgn0041094). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: negative regulation of growth; response to DNA damage stimulus; head involution; cell death. 18 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: RTP801, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, adult heart, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, adult Malpighian tubules, adult fat body, larval/adult salivary gland, adult ovary, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627101_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of scyl: 8 out of 14 probes fall into this exonic region. Gene sequence location is 3L:11245410..11248343.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN29797 HFA11392
FB2011_10	References Truscott et al., 2011, Genes Dev. 25(17): 1820--1834
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 68B4-68C1   Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
Experimentally Determined Cytological Location
Cytogenetic map Notes References 68C-68C     (Chauvet, 2000.1.5)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\scyl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) scyl-RA FBtr0076168  NM_140199   2192   280
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein scyl-PA   FBpp0075899   30.8   280   9.57     NP_648456   AAF50074
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RTP801, C-terminal (IPR012918)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202362   AA246952   AA263528   AA264627   AA264750   AA392103   AA392303   AA392403   AA438360   AA439566   AA440512   AA441270   AA694845   AA697781   AA816267   AA940697   AA941222   AA950084   AA950099   AA950700   AA978669   AE014296 AAF50074   AF221110 AAF59841   AI108753   AI238649   AI256907   AI257549   AI297152   AI388354   AI389068   AI945964   AX094091   AY075382 AAL68220   BG637733   BI166141   BI166766   BI166848   BI173305   BI213450   BI228789   BI229896   BI234047   BI235817   BI236487   BI236714   BI237922   BI241989   BI242975   BI243800   BI353553   BI353555   BI353561   BI366415   BI366820   BI373535   BI374006   BI484295   BI486821   BI568139   BI577625   BI579163   BI579876   BI610057   BI614170   BI638963   BI640169   BP543355   BP546735   BP558314   BQ103144   BQ103517   BT015975 AAV36860   BT057991   CA804577   CK131605   CO185292   CO188559   CO196248   CO265570   CO266549   CO267675   CO271605   CO274196   CO279842   CO283725   CO285976   CO287584   CO289006   CO291089   CO292277   CO292794   CO293339   CO294933   CO295507   CO295569   CO298430   CO301065   CO301279   CO302217   CO309401   CO309465   CO313875   CO314181   CO314931   CO315695   CO323185   CO331565   CO331728   CO332420   CO333871   CO340970   CO341143   CO341779   CZ470066   CZ470068   CZ485550   CZ485551   EC060585   EC062498   EC065384   EC071179   EC075885   EC076894   EC080638   EC081430   EC084510   EC087030   EC090558   EC195933   EC200321   EC204747   EC204872   EC208032   EC212480   EC215582   EC216502   EC216772   EC220456   EC223657   EC224461   EC225705   EC226701   EC228803   EC232887   EC233263   EC233359   EC234703   EC235982   EC236415   EC238396   EC241445   EC244183   EC246993   EC247131   EC247839   EC249519   EC253423   EC258674   EC260395   EC265047   GH748722   GH750452   GH879101   GH907762   GH913064   GH925694
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VTH4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041094    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041094 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041094 expression level Developmental Stage   Expression Level embryo 00-02hr    10309 embryo 02-04hr    12596 embryo 04-06hr    12237 embryo 06-08hr    13072 embryo 08-10hr    11826 embryo 10-12hr    10295 embryo 12-14hr    10500 embryo 14-16hr    9233 embryo 16-18hr    11488 embryo 18-20hr    10941 embryo 20-22hr    11660 embryo 22-24hr    12887 larva L1    7589 larva L2    3232 larva L3 12hr old    3942 larva L3 puffstage 1-2    2462 larva L3 puffstage 3-6    6066 larva L3 puffstage 7-9    11027 white prepupae new    13988 white prepupae 12hr    18143 white prepupae 24hr    13568 pupae 2d postWPP    12362 pupae 3d postWPP    4689 pupae 4d postWPP    8394 adult male 01day    5415 adult male 05day    5598 adult male 30day    5327 adult female 01day    6266 adult female 05day    6479 adult female 30day    6621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10309) embryo 02-04hr  (12596) embryo 04-06hr  (12237) embryo 06-08hr  (13072) embryo 08-10hr  (11826) embryo 10-12hr  (10295) embryo 12-14hr  (10500) embryo 14-16hr  (9233) embryo 16-18hr  (11488) embryo 18-20hr  (10941) embryo 20-22hr  (11660) embryo 22-24hr  (12887) larva L1  (7589) larva L2  (3232) larva L3 12hr old  (3942) larva L3 puffstage 1-2  (2462) larva L3 puffstage 3-6  (6066) larva L3 puffstage 7-9  (11027) white prepupae new  (13988) white prepupae 12hr  (18143) white prepupae 24hr  (13568) pupae 2d postWPP  (12362) pupae 3d postWPP  (4689) pupae 4d postWPP  (8394) adult male 01day  (5415) adult male 05day  (5598) adult male 30day  (5327) adult female 01day  (6266) adult female 05day  (6479) adult female 30day  (6621) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10309) embryo 02-04hr  (12596) embryo 04-06hr  (12237) embryo 06-08hr  (13072) embryo 08-10hr  (11826) embryo 10-12hr  (10295) embryo 12-14hr  (10500) embryo 14-16hr  (9233) embryo 16-18hr  (11488) embryo 18-20hr  (10941) embryo 20-22hr  (11660) embryo 22-24hr  (12887) larva L1  (7589) larva L2  (3232) larva L3 12hr old  (3942) larva L3 puffstage 1-2  (2462) larva L3 puffstage 3-6  (6066) larva L3 puffstage 7-9  (11027) white prepupae new  (13988) white prepupae 12hr  (18143) white prepupae 24hr  (13568) pupae 2d postWPP  (12362) pupae 3d postWPP  (4689) pupae 4d postWPP  (8394) adult male 01day  (5415) adult male 05day  (5598) adult male 30day  (5327) adult female 01day  (6266) adult female 05day  (6479) adult female 30day  (6621) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10309 embryo 02-04hr  (12596) embryo 04-06hr  (12237) embryo 06-08hr  (13072) embryo 08-10hr  (11826) embryo 10-12hr  10295 embryo 12-14hr  10500 embryo 14-16hr    9233 embryo 16-18hr  (11488) embryo 18-20hr  (10941) embryo 20-22hr  (11660) embryo 22-24hr  (12887) larva L1    7589 larva L2    3232 larva L3 12hr old    3942 larva L3 puffstage 1-2    2462 larva L3 puffstage 3-6    6066 larva L3 puffstage 7-9  (11027) white prepupae new  (13988) white prepupae 12hr  (18143) white prepupae 24hr  (13568) pupae 2d postWPP  (12362) pupae 3d postWPP    4689 pupae 4d postWPP    8394 adult male 01day    5415 adult male 05day    5598 adult male 30day    5327 adult female 01day    6266 adult female 05day    6479 adult female 30day    6621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10309 embryo 02-04hr    12596 embryo 04-06hr    12237 embryo 06-08hr    13072 embryo 08-10hr    11826 embryo 10-12hr    10295 embryo 12-14hr    10500 embryo 14-16hr    9233 embryo 16-18hr    11488 embryo 18-20hr    10941 embryo 20-22hr    11660 embryo 22-24hr    12887 larva L1    7589 larva L2    3232 larva L3 12hr old    3942 larva L3 puffstage 1-2    2462 larva L3 puffstage 3-6    6066 larva L3 puffstage 7-9    11027 white prepupae new    13988 white prepupae 12hr    18143 white prepupae 24hr    13568 pupae 2d postWPP    12362 pupae 3d postWPP    4689 pupae 4d postWPP    8394 adult male 01day    5415 adult male 05day    5598 adult male 30day    5327 adult female 01day    6266 adult female 05day    6479 adult female 30day    6621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041094 expression level Developmental Stage   Expression Level embryo 00-02hr    10309 embryo 02-04hr    12596 embryo 04-06hr    12237 embryo 06-08hr    13072 embryo 08-10hr    11826 embryo 10-12hr    10295 embryo 12-14hr    10500 embryo 14-16hr    9233 embryo 16-18hr    11488 embryo 18-20hr    10941 embryo 20-22hr    11660 embryo 22-24hr    12887 larva L1    7589 larva L2    3232 larva L3 12hr old    3942 larva L3 puffstage 1-2    2462 larva L3 puffstage 3-6    6066 larva L3 puffstage 7-9    11027 white prepupae new    13988 white prepupae 12hr    18143 white prepupae 24hr    13568 pupae 2d postWPP    12362 pupae 3d postWPP    4689 pupae 4d postWPP    8394 adult male 01day    5415 adult male 05day    5598 adult male 30day    5327 adult female 01day    6266 adult female 05day    6479 adult female 30day    6621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10309) embryo 02-04hr  (12596) embryo 04-06hr  (12237) embryo 06-08hr  (13072) embryo 08-10hr  (11826) embryo 10-12hr  (10295) embryo 12-14hr  (10500) embryo 14-16hr  (9233) embryo 16-18hr  (11488) embryo 18-20hr  (10941) embryo 20-22hr  (11660) embryo 22-24hr  (12887) larva L1  (7589) larva L2  (3232) larva L3 12hr old  (3942) larva L3 puffstage 1-2  (2462) larva L3 puffstage 3-6  (6066) larva L3 puffstage 7-9  (11027) white prepupae new  (13988) white prepupae 12hr  (18143) white prepupae 24hr  (13568) pupae 2d postWPP  (12362) pupae 3d postWPP  (4689) pupae 4d postWPP  (8394) adult male 01day  (5415) adult male 05day  (5598) adult male 30day  (5327) adult female 01day  (6266) adult female 05day  (6479) adult female 30day  (6621) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10309) embryo 02-04hr  (12596) embryo 04-06hr  (12237) embryo 06-08hr  (13072) embryo 08-10hr  (11826) embryo 10-12hr  (10295) embryo 12-14hr  (10500) embryo 14-16hr  (9233) embryo 16-18hr  (11488) embryo 18-20hr  (10941) embryo 20-22hr  (11660) embryo 22-24hr  (12887) larva L1  (7589) larva L2  (3232) larva L3 12hr old  (3942) larva L3 puffstage 1-2  2462 larva L3 puffstage 3-6  (6066) larva L3 puffstage 7-9  (11027) white prepupae new  (13988) white prepupae 12hr  (18143) white prepupae 24hr  (13568) pupae 2d postWPP  (12362) pupae 3d postWPP  (4689) pupae 4d postWPP  (8394) adult male 01day  (5415) adult male 05day  (5598) adult male 30day  (5327) adult female 01day  (6266) adult female 05day  (6479) adult female 30day  (6621) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10309 embryo 02-04hr  12596 embryo 04-06hr  12237 embryo 06-08hr  13072 embryo 08-10hr  11826 embryo 10-12hr  10295 embryo 12-14hr  10500 embryo 14-16hr    9233 embryo 16-18hr  11488 embryo 18-20hr  10941 embryo 20-22hr  11660 embryo 22-24hr  12887 larva L1    7589 larva L2    3232 larva L3 12hr old    3942 larva L3 puffstage 1-2    2462 larva L3 puffstage 3-6    6066 larva L3 puffstage 7-9  11027 white prepupae new  13988 white prepupae 12hr  18143 white prepupae 24hr  13568 pupae 2d postWPP  12362 pupae 3d postWPP    4689 pupae 4d postWPP    8394 adult male 01day    5415 adult male 05day    5598 adult male 30day    5327 adult female 01day    6266 adult female 05day    6479 adult female 30day    6621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10309 embryo 02-04hr    12596 embryo 04-06hr    12237 embryo 06-08hr    13072 embryo 08-10hr    11826 embryo 10-12hr    10295 embryo 12-14hr    10500 embryo 14-16hr    9233 embryo 16-18hr    11488 embryo 18-20hr    10941 embryo 20-22hr    11660 embryo 22-24hr    12887 larva L1    7589 larva L2    3232 larva L3 12hr old    3942 larva L3 puffstage 1-2    2462 larva L3 puffstage 3-6    6066 larva L3 puffstage 7-9    11027 white prepupae new    13988 white prepupae 12hr    18143 white prepupae 24hr    13568 pupae 2d postWPP    12362 pupae 3d postWPP    4689 pupae 4d postWPP    8394 adult male 01day    5415 adult male 05day    5598 adult male 30day    5327 adult female 01day    6266 adult female 05day    6479 adult female 30day    6621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041094    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041094 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, adult heart, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, adult Malpighian tubules, adult fat body, larval/adult salivary gland, adult ovary, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041094 expression level Tissue   Expression Level Larval Central Nervous System    508 Larval Midgut    270.1 Larval Hindgut    567.6 Larval Malpighian Tubules    1147.2 Larval Fat Body    58.2 Larval Salivary Gland    275.6 Larval Trachea    1183.325 Larval Carcass    185.025 Adult Head    321.8 Adult Eye    371.75 Adult Brain    442.4 Adult Thoracic-Abdominal Ganglion    427.8 Adult Crop    720.3 Adult Midgut    476.4 Adult Hindgut    647.8 Adult Malpighian Tubules    127.1 Adult Fat Body    326.5 Adult Salivary Gland    118.4 Adult Heart    1244.675 Adult VirginFemale Spermatheca    53.4 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    367 Adult Testis    104.4 Adult Male Accessory Gland    948.9 Adult Carcass    373.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  508 Larval Midgut    270.1 Larval Hindgut  (567.6) Larval Malpighian Tubules  (1147.2) Larval Fat Body    58.2 Larval Salivary Gland    275.6 Larval Trachea  (1183.325) Larval Carcass    185.025 Adult Head    321.8 Adult Eye    371.75 Adult Brain    442.4 Adult Thoracic-Abdominal Ganglion    427.8 Adult Crop  (720.3) Adult Midgut    476.4 Adult Hindgut  (647.8) Adult Malpighian Tubules    127.1 Adult Fat Body    326.5 Adult Salivary Gland    118.4 Adult Heart  (1244.675) Adult VirginFemale Spermatheca    53.4 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    367 Adult Testis    104.4 Adult Male Accessory Gland  (948.9) Adult Carcass    373.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    508 Larval Midgut    270.1 Larval Hindgut    567.6 Larval Malpighian Tubules  (1147.2) Larval Fat Body    58.2 Larval Salivary Gland    275.6 Larval Trachea  (1183.325) Larval Carcass    185.025 Adult Head    321.8 Adult Eye    371.75 Adult Brain    442.4 Adult Thoracic-Abdominal Ganglion    427.8 Adult Crop    720.3 Adult Midgut    476.4 Adult Hindgut    647.8 Adult Malpighian Tubules    127.1 Adult Fat Body    326.5 Adult Salivary Gland    118.4 Adult Heart  (1244.675) Adult VirginFemale Spermatheca    53.4 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    367 Adult Testis    104.4 Adult Male Accessory Gland    948.9 Adult Carcass    373.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    508 Larval Midgut    270.1 Larval Hindgut    567.6 Larval Malpighian Tubules    1147.2 Larval Fat Body    58.2 Larval Salivary Gland    275.6 Larval Trachea    1183.325 Larval Carcass    185.025 Adult Head    321.8 Adult Eye    371.75 Adult Brain    442.4 Adult Thoracic-Abdominal Ganglion    427.8 Adult Crop    720.3 Adult Midgut    476.4 Adult Hindgut    647.8 Adult Malpighian Tubules    127.1 Adult Fat Body    326.5 Adult Salivary Gland    118.4 Adult Heart    1244.675 Adult VirginFemale Spermatheca    53.4 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    367 Adult Testis    104.4 Adult Male Accessory Gland    948.9 Adult Carcass    373.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041094 expression level Tissue   Expression Level Larval Central Nervous System    508 Larval Midgut    270.1 Larval Hindgut    567.6 Larval Malpighian Tubules    1147.2 Larval Fat Body    58.2 Larval Salivary Gland    275.6 Larval Trachea    1183.325 Larval Carcass    185.025 Adult Head    321.8 Adult Eye    371.75 Adult Brain    442.4 Adult Thoracic-Abdominal Ganglion    427.8 Adult Crop    720.3 Adult Midgut    476.4 Adult Hindgut    647.8 Adult Malpighian Tubules    127.1 Adult Fat Body    326.5 Adult Salivary Gland    118.4 Adult Heart    1244.675 Adult VirginFemale Spermatheca    53.4 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    367 Adult Testis    104.4 Adult Male Accessory Gland    948.9 Adult Carcass    373.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  508 Larval Midgut    270.1 Larval Hindgut  567.6 Larval Malpighian Tubules  (1147.2) Larval Fat Body    58.2 Larval Salivary Gland    275.6 Larval Trachea  (1183.325) Larval Carcass    185.025 Adult Head    321.8 Adult Eye    371.75 Adult Brain    442.4 Adult Thoracic-Abdominal Ganglion    427.8 Adult Crop  720.3 Adult Midgut    476.4 Adult Hindgut  647.8 Adult Malpighian Tubules    127.1 Adult Fat Body    326.5 Adult Salivary Gland    118.4 Adult Heart  (1244.675) Adult VirginFemale Spermatheca    53.4 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    367 Adult Testis    104.4 Adult Male Accessory Gland  (948.9) Adult Carcass    373.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    508 Larval Midgut    270.1 Larval Hindgut    567.6 Larval Malpighian Tubules  1147.2 Larval Fat Body    58.2 Larval Salivary Gland    275.6 Larval Trachea  1183.325 Larval Carcass    185.025 Adult Head    321.8 Adult Eye    371.75 Adult Brain    442.4 Adult Thoracic-Abdominal Ganglion    427.8 Adult Crop    720.3 Adult Midgut    476.4 Adult Hindgut    647.8 Adult Malpighian Tubules    127.1 Adult Fat Body    326.5 Adult Salivary Gland    118.4 Adult Heart  1244.675 Adult VirginFemale Spermatheca    53.4 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    367 Adult Testis    104.4 Adult Male Accessory Gland    948.9 Adult Carcass    373.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    508 Larval Midgut    270.1 Larval Hindgut    567.6 Larval Malpighian Tubules    1147.2 Larval Fat Body    58.2 Larval Salivary Gland    275.6 Larval Trachea    1183.325 Larval Carcass    185.025 Adult Head    321.8 Adult Eye    371.75 Adult Brain    442.4 Adult Thoracic-Abdominal Ganglion    427.8 Adult Crop    720.3 Adult Midgut    476.4 Adult Hindgut    647.8 Adult Malpighian Tubules    127.1 Adult Fat Body    326.5 Adult Salivary Gland    118.4 Adult Heart    1244.675 Adult VirginFemale Spermatheca    53.4 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    367 Adult Testis    104.4 Adult Male Accessory Gland    948.9 Adult Carcass    373.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    321.8   NA  Eye    371.75   NA  Brain    442.4   508  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    427.8   NA  Crop    720.3   270.1  Midgut    476.4   567.6  Hindgut    647.8   1147.2  Malpighian Tubules    127.1   58.2  Fat Body    326.5   275.6  Salivary Gland    118.4   NA  Heart    1244.675   1183.325  Trachea    NA   NA  VirginFemale Spermatheca    53.4   NA  InseminatedFemale Spermatheca    60.8   NA  Ovary    367   NA  Testis    104.4   NA  Male Accessory Gland    948.9   185.025  Carcass    373.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041094 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7590-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable scylunspecified viable, with Scer\GAL4pnr-MD237 scylGD9925 Sterility Allele fertile scylunspecified Other Phenotypes Allele decreased cell size, with Scer\GAL4Act5C.PF scylEP22.1 decreased cell size | somatic clone, with Scer\GAL4GMR.PB scylEP22.1 long lived, with Scer\GAL4da.G32 scylEP22.1 small body, with Scer\GAL4Act5C.PF scylEP22.1 Phenotype manifest in Allele
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of scyl Class Mutagen Stocks Known lesion scylZCL0611 P-element activity 2 -- scylc06271 1 -- scyle03543 1 -- scylf02993 piggyBac transposase 1 -- scylG19318 P-element activity 1 -- scylMI02637 1 -- scylNP0206 1 -- scyl113 Delta2-3 0 Yes scyl31 Delta2-3 0 Yes scylc03518 0 -- scylc05525 piggyBac transposase 0 -- scylEP22.1 0 Yes scylEP9.85 0 Yes scylunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of scyl Class Mutagen Stocks Known lesion scylGD9925 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes scylGD16504 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes scylScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes scylΔ1-12.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9925} NA P{GD16504} NA P{UAS-scyl.R} NA P{UAS-scyl.Δ1-12} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}scylMI02637 NA P{EP.Scer\UAS(loxP.Scer\UAS.y+).BN}scylEP9.85 NA P{EP.Scer\UAS(loxP.Scer\UAS.y+).BN}scylEP22.1 NA P{GT1}BG01560 NA P{PTT-GC}scylZCL0611 NA PBac{PB}scylc03518 NA PBac{PB}scylc05525 NA PBac{PB}scylc06271 NA PBac{RB}scyle03543 NA PBac{WH}scylf02993 NA insertion of mobile activating element P{EP}scylG19318 NA P{EPgy2}EY03729 NA insertion of enhancer trap binary system P{GawB}scylNP0206 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2007-10-12)
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell death inferred from mutant phenotype (Scuderi et al., 2006) head involution inferred from mutant phenotype (Scuderi et al., 2006) negative regulation of growth inferred from genetic interaction with chrb (Reiling and Hafen, 2004) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
negative regulation of signal transduction inferred from electronic annotation with InterPro:IPR012918 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR012918 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions scyl allele Gene References scyl31 chrb (Reiling and Hafen, 2004) scyl113 chrb (Reiling and Hafen, 2004) scylEP9.85 chrb (Reiling and Hafen, 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64642 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041094 DroID - A comprehensive database of gene and protein interactions. • FBgn0041094 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39270
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25255 Dere\GG15494 Dgri\GH16643 Dmoj\GI11599 Dper\GL22775 Dpse\GA20462 Dsec\GM25265 Dsim\GD14299 Dvir\GJ11278 Dwil\GK17162 Dyak\GE21804
Curated drosophilid orthologs	Dpse\GA20462   Dsim\scylla (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008054-PA Aedes aegypti (mosquito) ENSBTAP00000000187 Bos taurus (bovine) ENSCAFP00000021295 Canis familiaris (dog) ENSCPOP00000014709 Cavia porcellus (guinea pig) 186269 Capitella spl (polychaete worm) ENSECAP00000002820 Equus caballus (horse) ENSP00000307305 Homo sapiens (human) ENSMODP00000000033 Monodelphis domestica (gray opossum) ENSMMUP00000016133 Macaca mulatta (rhesus monkey) ENSMUSP00000058896 Mus musculus (house mouse) ENSOANP00000004868 Ornithorynchus anatinus (platypus) ENSORLP00000011504 Oryzias latipes (japanese killifish) ENSPPYP00000002733 Pongo pygmaeus (orangutan) ENSPTRP00000004530 Pan troglodytes (chimpanzee) ENSRNOP00000013661 Rattus norvegicus (norway rat) XP_967838.1 Tribolium castaneum (red flour beetle) ENSTRUP00000021674 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15583 LH23383 FBgn0239060 FBgn0239049 FBgn0219171 FBgn0219161 FBgn0198555 FBgn0198539 FBgn0185995 FBgn0185984 FBgn0180135 FBgn0180125 JGI_V11_223163 FBgn0080457 FBgn0080415 FBgn0160387 FBgn0160366 FBgn0134374 FBgn0134359 FBgn0036165 FBgn0124126 FBgn0124114 FBgn0107757 FBgn0107744 FBgn0102259 FBgn0102247 CPIJ013164 BGIBMGA007397 ACYPI007771 GB14178 AGAP011600 AAEL008054 PHUM125930 GLEAN_06266 GLEAN_05886 GLEAN_05887
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	26958 y1 w*; P{EP}scylG19318 35873 y1 w*; Mi{MIC}scylMI02637 6823 y1 w1118; P{PTT-GC}scylZCL0611/TM3, Ser1
Harvard	- PBac{PB}scylc06271 - PBac{RB}scyle03543 - PBac{WH}scylf02993
Kyoto	110736 P{PTT-GC}scylZCL0611 112085 w*; P{GawB}scylNP0206 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v25506 w1118; P{GD9925}v25506 v25504 w1118; P{GD9925}v25504/CyO
Genomic Clones ( 2 )
	BACR19G23 BACR23K09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 158 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22812 RE71335
Other clones	DPiM_FI04493 FI04493
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07985 GH14733 GH19225 GH20150 GM01658 GM24150 GM24162 GM24186 HL03145 LD01120 LD02003 LD02513 LD05974 LD06676 LD08235 LD08450 LD11148 LD11256 LD12461 LD12620 LD14172 LD14736 LD16146 LD25242 LD28628 LD30054 LD30692 LD32640 LP03630 LP05951 LP11391 LP12506 RE06172 RE06980 RE07074 RE16203 RE18854 RE26433 RE29676 RE31753 RE32546 RE32821 RE34256 RE39202 RE40486 RE41545 RE51949 RE52439 RE60851 RE61505 RE67374 RE70292 RE73149 RE73972 RH14929 RH39521 RH43482 SD21372 SD22971
Other clones	12426 19378 28652 29591 32837 35911 54563 58219 59237 64223 71507 72248 73376 76767 77504 78511 83393 83625 83888 107768 108796 118995 153018 158081 159284 166063 181758 191176 214339.43 214499.42 214577.26 273423 274032 282363 557003 bs18h04 CK01.3B.G5 CK01.48D.H1 CK01.63A.A10 CK01.78D.D12 CK01.82D.H11 CK01.98C.E1 CK01.123A.G11 CK01.169D.E9 EK002407 EK007621 EK040929 EK061336 EK066230 EK069903 EK076113 EK104019 EK113526 EK136143 EK143027 EK146829 EK151503 EK164160 EK173002 EK180011 EK180627 EK183653 EK189912 EK199658 EK200956 EK202617 EK208013 EK210244 EK210727 EK217520 EK217718 EK234219 EK235249 EK238422 EK262228 EK300535 EK301518 EK303408 EK308222 EP11645 EP11936 EP13134 ESG0114b.B21_B09 FGC020A07 FGH109E10 FGM314C05 RE27774 RP003036137 RP003075726 RP003127250 RP003203432 RP003372625 RP003390038 UUGC0542 UUGC0924
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041094 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39270
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: scyl anon-WO0118547.215 (FlyBase, 1996-) Source for merge of: scylla CG7590 (Bayraktaroglu, 2000.8.7)
Additional comments	Source for merge of scyl anon-WO0118547.215 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	scyl functions redundantly to chrb and is a downstream target of homeobox regulation. (Scuderi et al., 2006) Embryos injected with dsRNA made from templates generated with primers directed against this gene show no observable phenotype. However, embryos injected with dsRNA against both this gene and chrb are embryonic lethal and show defects in head involution. (Scuderi et al., 2006) Area matching Drosophila ESTs AA950084 and AA978669. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140199 RefSeq (Proteins) • NP_648456 DDBJ / EMBL / GenBank • AA264627 AA940697 AA950084 AA978669 AAF50074 AAF59841 AAL68220 AAS65038 AAV36860 AF221110 AI945964 AX094091 AY075382 BI577625 BT015975 CZ470066 CZ470068 CZ485550 CZ485551 Entrez Gene - A searchable database of RefSeq genes. • 39270 UniProtKB/TrEMBL • Q9VTH4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RTP801, C-terminal (IPR012918)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64642 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041094 DroID - A comprehensive database of gene and protein interactions. • FBgn0041094 DRSC - Results from RNAi screens. • FBgn0041094 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041094 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7590-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041094 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39270 InParanoid A subset of ortholog calls from InParanoid. • AAEL008054-PA Aedes aegypti (mosquito) ENSBTAP00000000187 Bos taurus (bovine) ENSCAFP00000021295 Canis familiaris (dog) ENSCPOP00000014709 Cavia porcellus (guinea pig) 186269 Capitella spl (polychaete worm) ENSECAP00000002820 Equus caballus (horse) ENSP00000307305 Homo sapiens (human) ENSMODP00000000033 Monodelphis domestica (gray opossum) ENSMMUP00000016133 Macaca mulatta (rhesus monkey) ENSMUSP00000058896 Mus musculus (house mouse) ENSOANP00000004868 Ornithorynchus anatinus (platypus) ENSORLP00000011504 Oryzias latipes (japanese killifish) ENSPPYP00000002733 Pongo pygmaeus (orangutan) ENSPTRP00000004530 Pan troglodytes (chimpanzee) ENSRNOP00000013661 Rattus norvegicus (norway rat) XP_967838.1 Tribolium castaneum (red flour beetle) ENSTRUP00000021674 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/scyllaandchar1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39270 modMine - Data generated by the modENCODE project. • FBgn0041094 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15583 LH23383 FBgn0239060 FBgn0239049 FBgn0219171 FBgn0219161 FBgn0198555 FBgn0198539 FBgn0185995 FBgn0185984 FBgn0180135 FBgn0180125 JGI_V11_223163 FBgn0080457 FBgn0080415 FBgn0160387 FBgn0160366 FBgn0134374 FBgn0134359 FBgn0036165 FBgn0124126 FBgn0124114 FBgn0107757 FBgn0107744 FBgn0102259 FBgn0102247 CPIJ013164 BGIBMGA007397 ACYPI007771 GB14178 AGAP011600 AAEL008054 PHUM125930 GLEAN_06266 GLEAN_05886 GLEAN_05887
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	7590 (Ravi et al., 2009) anon-WO0118547.215   CG7590 (Brody et al., 2002, Labourier et al., 2002, Quinones-Coello, 2007, Zhang et al., 2008) scy (Reiling and Hafen, 2004) scyl (Scuderi et al., 2006, Blanco et al., 2010, Mensch et al., 2008, Foley et al., 2010) scylla (Akdemir et al., 2007)
Name Synonym	scylla (Kazuko et al., 2004, Quinones-Coello, 2007, Truscott et al., 2011) Scylla (Wullschleger, 2006)
Secondary FlyBase IDs
	FBgn0036151 FBgn0062166
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 2 ) FlyBase analysis  ( 4 ) Patent  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 )
Recent research papers ( 4 )
	Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Truscott et al., 2011, Genes Dev. 25(17): 1820--1834 mir-11 limits the proapoptotic function of its host gene, dE2f1. [FBrf0215211] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Foley et al., 2010, Biol. Letts 6(1): 102--105 Does segregating variation in sexual or microhabitat preferences lead to non-random mating within a population of Drosophila melanogaster? [FBrf0209672] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...