Rols7, Ants, l(3)08232, Antisocial
RING-finger motif, ankyrin repeat and TR repeat protein - a signaling protein that interacts with the cytoplasmic domain of Dumbfounded and with Myoblast city - functions to integrate initial myoblast fusion with myotube structural organization
Gene model reviewed during 5.42
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
7, 6 (northern blot)
1900 (aa); 205 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rols using the Feature Mapper tool.
rols transcription from the upstream promoter (called rols7) is observed in the differentiating embryonic somatic and visceral mesoderm. Transcription from the downstream rols promoter (called rols6) is strong in early embryonic stage 11 between the ectodermal hindgut anlage and the posterior midgut primordium, where the renal tubes originate. Transcription continues throughout Malpighian tubule development.
Transcript is first detected in the progenitors of visceral, somatic and pharyngeal muscles. Visceral mesoderm expression decreases during germband shortening while somatic mesoderm expression persists. At stage 15 rols transcript is no longer detected in the mesoderm but rather in muscle attachment sites along the segmental border.
GBrowse - Visual display of RNA-Seq signalsView Dmel\rols in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG12277, CG17155, CG5679 merged as CG32096 in release 3 of the genome annotation.
"CG17155" is a candidate gene for "E(sda)H".
Source for merge of rols CG12277 was sequence identity ( date:011221 ).
Source for merge of rols anon-WO0257455.19 was sequence comparison ( date:051113 ).
Source for merge of rols CG17155 CG5679 was sequence comparison ( date:011124 ).
rols acts during myoblast fusion to link the initial event of myoblast attraction with the downstream event of myotubule structural organisation.
The fusion process during muscle development is severely disrupted in mutant embryos.
Complementation groups l(3)68Fa, l(3)68Fb, l(3)68Fc, l(3)68Fd, l(3)68Fe, Nrx-IV, l(3)69Aa and l(3)69Ab isolated by Hoogwerf et al. (FBrf0048238) probably correspond to complementation groups l(3)68Fg, l(3)j2D3, l(3)68Fh, rols, l(3)68Fi, Nrx-IV, l(3)69Ah and l(3)69Ai isolated by Baumgartner at al, 1996, Cell 87: 1059--1068, but a one to one correspondence cannot be made as Hoogwerf mutations are apparently lost.
The gene is named "rolling pebbles" after the mutant phenotype; mutant embryos have a scattered distribution of unfused myoblasts.