Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Gene model reviewed during 6.32
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\robo3 using the Feature Mapper tool.
robo3 is expressed specifically and transiently in photoreceptor R8 growth cones. robo3 is expressed in third instar larval R8 growth cones as they enter the optic lobe, displays a graded pattern of staining with decreased staining in axons extending further toward their final layer, and is downregulated shortly after the R8 axons enter the medulla neuropil. However, residual robo3 staining is observed in the growth cones of other optic lobe neurons that project into more proximal regions of the developing medulla neuropil.
GBrowse - Visual display of RNA-Seq signalsView Dmel\robo3 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The lateral positioning of longitudinal axon pathways in the embryo relies primarily on differences in robo gene regulation, not on distinct combinations of the three robo proteins (robo, lea and robo3) as previously thought. However, the unique structural features of robo are required to prevent midline crossing and the unique structural features of lea are required to promote midline crossing.
Ectopic expression of robo3 in md neurons switches their terminal arbor from a medial to an intermediate fascicle.