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General Information
Symbol
Dmel\lilli
Species
D. melanogaster
Name
lilliputian
Annotation Symbol
CG8817
Feature Type
FlyBase ID
FBgn0041111
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
l(2)00632, Su(Raf)2A, SS2-1, AFF4, SY2-1
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:2,885,929..2,954,406 [+]
Recombination map
2-8
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the AF4 family. (Q9VQI9)
Summaries
Gene Group (FlyBase)
OTHER DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
The Other DNA binding domain transcription factors group is a collection of DNA-binding transcription factors that do not fit into any of the other major domain-based transcription factor groups.
Protein Function (UniProtKB)
Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.
(UniProt, Q9VQI9)
Summary (Interactive Fly)
transcription factor - Fragile X mental retardation 2 (Fmr2) family - Functions in MAPK and Dpp signaling pathways - affects growth, a function associated with the insulin pathway - affects the cytoskeleton early in development.
Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\lilli or the JBrowse view of Dmel\lilli for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.13
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0077632
7956
1673
FBtr0077633
9683
1673
FBtr0077634
7243
1673
FBtr0290038
5228
1614
FBtr0290039
6134
1614
FBtr0290040
5337
1614
FBtr0290041
7438
1673
FBtr0332458
7591
1614
FBtr0452101
7025
1626
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0077317
180.1
1673
9.69
FBpp0077318
180.1
1673
9.69
FBpp0077319
180.1
1673
9.69
FBpp0288477
173.0
1614
9.76
FBpp0288478
173.0
1614
9.76
FBpp0288479
173.0
1614
9.76
FBpp0288480
180.1
1673
9.69
FBpp0304731
173.0
1614
9.76
FBpp0402856
174.5
1626
9.84
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1673 aa isoforms: lilli-PA, lilli-PB, lilli-PC, lilli-PG
1614 aa isoforms: lilli-PD, lilli-PE, lilli-PF, lilli-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Component of the super elongation complex (SEC), at least composed of Ell, Cdk9, cyclin-T (CycT), lilli and ear.
(UniProt, Q9VQI9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lilli using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (21 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with HGNC:6473
inferred from sequence or structural similarity with HGNC:7135
inferred from sequence or structural similarity with HGNC:6473
inferred from sequence or structural similarity with HGNC:7135
inferred from biological aspect of ancestor with PANTHER:PTN000829417
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000829417
(assigned by GO_Central )
Biological Process (13 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:E(spl)mγ-HLH; FB:FBgn0002735, FLYBASE:Su(Tpl); FB:FBgn0014037
inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647
inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647, FLYBASE:lilli; FB:FBgn0041111
inferred from genetic interaction with FLYBASE:Su(Tpl); FB:FBgn0014037
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Su(Tpl); FB:FBgn0014037
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from high throughput mutant phenotype
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Su(Tpl); FB:FBgn0014037
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000829417
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000829417
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:6473
inferred from sequence or structural similarity with HGNC:7135
inferred from biological aspect of ancestor with PANTHER:PTN000829417
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Su(Tpl); FB:FBgn0014037
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
Reporter: P{GawB}lilli189Y
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PZ}lilli00632
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\lilli in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 73 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of lilli
Transgenic constructs containing regulatory region of lilli
Deletions and Duplications ( 20 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
8 of 15
Yes
No
 
8 of 15
Yes
No
 
7 of 15
Yes
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
9 of 15
Yes
Yes
9 of 15
Yes
Yes
7 of 15
Yes
No
Rattus norvegicus (Norway rat) (4)
7 of 13
Yes
Yes
6 of 13
No
Yes
5 of 13
No
Yes
3 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
3 of 12
Yes
Yes
3 of 12
Yes
Yes
2 of 12
No
Yes
Danio rerio (Zebrafish) (4)
9 of 15
Yes
Yes
6 of 15
No
Yes
6 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
1 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904QN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150444 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CZK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CXH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0KKW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Component of the super elongation complex (SEC), at least composed of Ell, Cdk9, cyclin-T (CycT), lilli and ear.
    (UniProt, Q9VQI9 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-8
    Cytogenetic map
    Sequence location
    2L:2,885,929..2,954,406 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    23C1-23C3
    Limits computationally determined from genome sequence between P{PZ}oho23B03575 and P{PZ}lilli00632
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    23C1-23C2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (41)
    Genomic Clones (54)
    cDNA Clones (42)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: lilli CG8817
      Source for database merge of
      Source for merge of: lilli SY2-1 Su(Raf)2A l(2)k07920
      Source for merge of: lilli l(2)23Cc
      Source for merge of: lilli BEST:GH09955
      Source for merge of: lilli BcDNA:GM02019
      Additional comments
      Source for identity of lilli CG8817 was sequence comparison ( date:010129 ).
      Source for merge of lilli BcDNA:GM02019 was a shared cDNA ( date:030728 ).
      Other Comments
      lilli is acutely required at the blastoderm stage for the run-dependent activation of ftz.
      lilli is required for transcriptional activation of the Sxl embryonic promoter.
      Embryos lacking maternal lilli function show specific defects in the establishment of a functional cytoskeleton during cellularisation, and show a pair-rule segmentation phenotype.
      Loss of lilli function causes an autonomous reduction in cell size.
      Maternal contribution of the lilli gene is important for formation of segmentation pattern during embryogenesis.
      lilli homozygous clones produce small cells.
      40 "SS2-1" alleles of lilli have been isolated in a screen for dominant modifiers of the sinaGMR.PN eye phenotype.
      Identified in a genetic screen for modifiers of the phl::tor12D.sev rough eye mutant phenotype. Clonal analysis reveals that lilli is not required for normal eye development.
      The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
      Origin and Etymology
      Discoverer
      Etymology
      The gene is named "lilliputian" based on the small size of homozygous mutant cells.
      Identification
      In an EMS screen for dominant modifiers of the eye phenotype caused by expression of sensScer\UAS.cNa under the control of Scer\GAL4lz-gal4. 2 alleles of lilli have been isolated in the screen.
      External Crossreferences and Linkouts ( 105 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      ApoDroso - Functional genomic database for photoreceptor development, survival and function
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (25)
      Reported As
      Symbol Synonym
      BEST:GH09955
      BcDNA:GM02019
      l(2)k07920
      l(2)k16124
      Secondary FlyBase IDs
      • FBgn0010466
      • FBgn0016741
      • FBgn0026635
      • FBgn0026643
      • FBgn0031481
      • FBgn0040119
      • FBgn0045826
      • FBgn0047289
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (139)