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Gene Dmel\ago

General Information
Symbol	Dmel\ago	Species	D. melanogaster
Name	archipelago	Annotation symbol	CG15010
Feature type	protein_coding_gene	FlyBase ID	FBgn0041171
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	64A11-64A12	Sequence location	3L:4,246,326..4,254,309 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene archipelago is referred to in FlyBase by the symbol Dmel\ago (CG15010, FBgn0041171). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process: negative regulation of growth; negative regulation of glial cell proliferation; axon guidance; regulation of mitosis; DNA endoreduplication. 42 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: F-box domain, Skp2-like; F-box domain, cyclin-like; G-protein beta WD-40 repeat; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633515_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of ago. Gene sequence location is 3L:4246326..4254309.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA08463 BKN27400
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64A11-64A12   Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3- (Moberg and Hariharan, 2000)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ago for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ago-RA FBtr0073247  NM_168072   5308   1326 ago-RB FBtr0073246  NM_168073   5285   1326 ago-RC FBtr0073245  NM_079198   5352   1326
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ago-PA   FBpp0073103   141.4   1326   4.90     NP_728964   AAF47869 ago-PB   FBpp0073102   141.4   1326   4.90     NP_728965   AAG22247 ago-PC   FBpp0073101   141.4   1326   4.90     NP_523922   AAG22246
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) F-box domain, cyclin-like (IPR001810) WD40 repeat-like-containing domain (IPR011046) WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472) F-box domain, Skp2-like (IPR022364)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202746   AA246374   AA247005   AA264781   AA392017   AA392932   AA438476   AA438526   AA440242   AA539097   AA539257   AA539817   AA540487   AA735443   AA816403   AA816458   AA816893   AA820228   AA941170   AA941674   AA942022   AA942370   AA950467   AA951151   AA978412   AA978426   AA978568   AE014296 AAF47869   AE014296 AAG22246   AE014296 AAG22247   AI134246   AI512057   AI512540   AI513051   AI513361   AI514583   AI515217   AI516040   AI544079   AW942590   AW943018   AX094221   AY061300 AAL28848   AY075401 AAL68231   BE975298   BE975947   BG638212   BG639149   BI164644   BI169225   BI171283   BI230879   BI237225   BI239727   BI242445   BI243706   BI356248   BI356680   BI361528   BI374724   BI375239   BI484941   BI485008   BI487090   BI637620   CK662241   CL706557   CO177906   CO185698   CO274696   CO284166   CO298189   CO304199   CO306917   CO325869   CO327201   CO331478   CO343672   CO345231   CZ475261   CZ476624   CZ476644   CZ477125   CZ477597   CZ477768   CZ477810   EC052380   EC053438   EC062720   EC065249   EC083546   EC085109   EC199705   EC200679   EC203875   EC213273   EC237706   EC240477   EC253022   EC254487   EC255218   EC256209   EV578469   EV590929   EV595500
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VZF4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041171    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041171 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041171 expression level Developmental Stage   Expression Level embryo 00-02hr    12153 embryo 02-04hr    17358 embryo 04-06hr    17999 embryo 06-08hr    15216 embryo 08-10hr    11632 embryo 10-12hr    7933 embryo 12-14hr    5246 embryo 14-16hr    5982 embryo 16-18hr    4310 embryo 18-20hr    2643 embryo 20-22hr    4597 embryo 22-24hr    3988 larva L1    1467 larva L2    905 larva L3 12hr old    818 larva L3 puffstage 1-2    890 larva L3 puffstage 3-6    1912 larva L3 puffstage 7-9    2394 white prepupae new    3063 white prepupae 12hr    3368 white prepupae 24hr    3900 pupae 2d postWPP    2407 pupae 3d postWPP    1357 pupae 4d postWPP    1346 adult male 01day    1545 adult male 05day    1910 adult male 30day    1789 adult female 01day    3872 adult female 05day    5892 adult female 30day    6040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12153) embryo 02-04hr  (17358) embryo 04-06hr  (17999) embryo 06-08hr  (15216) embryo 08-10hr  (11632) embryo 10-12hr  (7933) embryo 12-14hr  (5246) embryo 14-16hr  (5982) embryo 16-18hr  (4310) embryo 18-20hr  (2643) embryo 20-22hr  (4597) embryo 22-24hr  (3988) larva L1  (1467) larva L2  (905) larva L3 12hr old  (818) larva L3 puffstage 1-2  (890) larva L3 puffstage 3-6  (1912) larva L3 puffstage 7-9  (2394) white prepupae new  (3063) white prepupae 12hr  (3368) white prepupae 24hr  (3900) pupae 2d postWPP  (2407) pupae 3d postWPP  (1357) pupae 4d postWPP  (1346) adult male 01day  (1545) adult male 05day  (1910) adult male 30day  (1789) adult female 01day  (3872) adult female 05day  (5892) adult female 30day  (6040) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12153) embryo 02-04hr  (17358) embryo 04-06hr  (17999) embryo 06-08hr  (15216) embryo 08-10hr  (11632) embryo 10-12hr  (7933) embryo 12-14hr  (5246) embryo 14-16hr  (5982) embryo 16-18hr  (4310) embryo 18-20hr  (2643) embryo 20-22hr  (4597) embryo 22-24hr  (3988) larva L1  1467 larva L2    905 larva L3 12hr old    818 larva L3 puffstage 1-2    890 larva L3 puffstage 3-6  (1912) larva L3 puffstage 7-9  (2394) white prepupae new  (3063) white prepupae 12hr  (3368) white prepupae 24hr  (3900) pupae 2d postWPP  (2407) pupae 3d postWPP    1357 pupae 4d postWPP    1346 adult male 01day  (1545) adult male 05day  (1910) adult male 30day  (1789) adult female 01day  (3872) adult female 05day  (5892) adult female 30day  (6040) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (12153) embryo 02-04hr  (17358) embryo 04-06hr  (17999) embryo 06-08hr  (15216) embryo 08-10hr  (11632) embryo 10-12hr    7933 embryo 12-14hr    5246 embryo 14-16hr    5982 embryo 16-18hr    4310 embryo 18-20hr    2643 embryo 20-22hr    4597 embryo 22-24hr    3988 larva L1    1467 larva L2    905 larva L3 12hr old    818 larva L3 puffstage 1-2    890 larva L3 puffstage 3-6    1912 larva L3 puffstage 7-9    2394 white prepupae new    3063 white prepupae 12hr    3368 white prepupae 24hr    3900 pupae 2d postWPP    2407 pupae 3d postWPP    1357 pupae 4d postWPP    1346 adult male 01day    1545 adult male 05day    1910 adult male 30day    1789 adult female 01day    3872 adult female 05day    5892 adult female 30day    6040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12153 embryo 02-04hr    17358 embryo 04-06hr    17999 embryo 06-08hr    15216 embryo 08-10hr    11632 embryo 10-12hr    7933 embryo 12-14hr    5246 embryo 14-16hr    5982 embryo 16-18hr    4310 embryo 18-20hr    2643 embryo 20-22hr    4597 embryo 22-24hr    3988 larva L1    1467 larva L2    905 larva L3 12hr old    818 larva L3 puffstage 1-2    890 larva L3 puffstage 3-6    1912 larva L3 puffstage 7-9    2394 white prepupae new    3063 white prepupae 12hr    3368 white prepupae 24hr    3900 pupae 2d postWPP    2407 pupae 3d postWPP    1357 pupae 4d postWPP    1346 adult male 01day    1545 adult male 05day    1910 adult male 30day    1789 adult female 01day    3872 adult female 05day    5892 adult female 30day    6040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041171 expression level Developmental Stage   Expression Level embryo 00-02hr    12153 embryo 02-04hr    17358 embryo 04-06hr    17999 embryo 06-08hr    15216 embryo 08-10hr    11632 embryo 10-12hr    7933 embryo 12-14hr    5246 embryo 14-16hr    5982 embryo 16-18hr    4310 embryo 18-20hr    2643 embryo 20-22hr    4597 embryo 22-24hr    3988 larva L1    1467 larva L2    905 larva L3 12hr old    818 larva L3 puffstage 1-2    890 larva L3 puffstage 3-6    1912 larva L3 puffstage 7-9    2394 white prepupae new    3063 white prepupae 12hr    3368 white prepupae 24hr    3900 pupae 2d postWPP    2407 pupae 3d postWPP    1357 pupae 4d postWPP    1346 adult male 01day    1545 adult male 05day    1910 adult male 30day    1789 adult female 01day    3872 adult female 05day    5892 adult female 30day    6040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12153) embryo 02-04hr  (17358) embryo 04-06hr  (17999) embryo 06-08hr  (15216) embryo 08-10hr  (11632) embryo 10-12hr  (7933) embryo 12-14hr  (5246) embryo 14-16hr  (5982) embryo 16-18hr  (4310) embryo 18-20hr  (2643) embryo 20-22hr  (4597) embryo 22-24hr  (3988) larva L1  (1467) larva L2  (905) larva L3 12hr old  (818) larva L3 puffstage 1-2  (890) larva L3 puffstage 3-6  (1912) larva L3 puffstage 7-9  (2394) white prepupae new  (3063) white prepupae 12hr  (3368) white prepupae 24hr  (3900) pupae 2d postWPP  (2407) pupae 3d postWPP  (1357) pupae 4d postWPP  (1346) adult male 01day  (1545) adult male 05day  (1910) adult male 30day  (1789) adult female 01day  (3872) adult female 05day  (5892) adult female 30day  (6040) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12153) embryo 02-04hr  (17358) embryo 04-06hr  (17999) embryo 06-08hr  (15216) embryo 08-10hr  (11632) embryo 10-12hr  (7933) embryo 12-14hr  (5246) embryo 14-16hr  (5982) embryo 16-18hr  (4310) embryo 18-20hr  (2643) embryo 20-22hr  (4597) embryo 22-24hr  (3988) larva L1  1467 larva L2    905 larva L3 12hr old    818 larva L3 puffstage 1-2    890 larva L3 puffstage 3-6  1912 larva L3 puffstage 7-9  2394 white prepupae new  (3063) white prepupae 12hr  (3368) white prepupae 24hr  (3900) pupae 2d postWPP  2407 pupae 3d postWPP    1357 pupae 4d postWPP    1346 adult male 01day  1545 adult male 05day  1910 adult male 30day  1789 adult female 01day  (3872) adult female 05day  (5892) adult female 30day  (6040) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  12153 embryo 02-04hr  17358 embryo 04-06hr  17999 embryo 06-08hr  15216 embryo 08-10hr  11632 embryo 10-12hr    7933 embryo 12-14hr    5246 embryo 14-16hr    5982 embryo 16-18hr    4310 embryo 18-20hr    2643 embryo 20-22hr    4597 embryo 22-24hr    3988 larva L1    1467 larva L2    905 larva L3 12hr old    818 larva L3 puffstage 1-2    890 larva L3 puffstage 3-6    1912 larva L3 puffstage 7-9    2394 white prepupae new    3063 white prepupae 12hr    3368 white prepupae 24hr    3900 pupae 2d postWPP    2407 pupae 3d postWPP    1357 pupae 4d postWPP    1346 adult male 01day    1545 adult male 05day    1910 adult male 30day    1789 adult female 01day    3872 adult female 05day    5892 adult female 30day    6040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12153 embryo 02-04hr    17358 embryo 04-06hr    17999 embryo 06-08hr    15216 embryo 08-10hr    11632 embryo 10-12hr    7933 embryo 12-14hr    5246 embryo 14-16hr    5982 embryo 16-18hr    4310 embryo 18-20hr    2643 embryo 20-22hr    4597 embryo 22-24hr    3988 larva L1    1467 larva L2    905 larva L3 12hr old    818 larva L3 puffstage 1-2    890 larva L3 puffstage 3-6    1912 larva L3 puffstage 7-9    2394 white prepupae new    3063 white prepupae 12hr    3368 white prepupae 24hr    3900 pupae 2d postWPP    2407 pupae 3d postWPP    1357 pupae 4d postWPP    1346 adult male 01day    1545 adult male 05day    1910 adult male 30day    1789 adult female 01day    3872 adult female 05day    5892 adult female 30day    6040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041171    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041171 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041171 expression level Tissue   Expression Level Larval Central Nervous System    409.225 Larval Midgut    171.9 Larval Hindgut    217.1 Larval Malpighian Tubules    292.4 Larval Fat Body    379.5 Larval Salivary Gland    550.4 Larval Trachea    269.875 Larval Carcass    300.325 Adult Head    153.2 Adult Eye    225.65 Adult Brain    239.7 Adult Thoracic-Abdominal Ganglion    219.8 Adult Crop    211.8 Adult Midgut    180.3 Adult Hindgut    176.2 Adult Malpighian Tubules    279.5 Adult Fat Body    207 Adult Salivary Gland    221.6 Adult Heart    186.375 Adult VirginFemale Spermatheca    407.5 Adult InseminatedFemale Spermatheca    459.9 Adult Ovary    490.3 Adult Testis    334.1 Adult Male Accessory Gland    126.6 Adult Carcass    135.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    409.225 Larval Midgut    171.9 Larval Hindgut    217.1 Larval Malpighian Tubules    292.4 Larval Fat Body    379.5 Larval Salivary Gland  (550.4) Larval Trachea    269.875 Larval Carcass    300.325 Adult Head    153.2 Adult Eye    225.65 Adult Brain    239.7 Adult Thoracic-Abdominal Ganglion    219.8 Adult Crop    211.8 Adult Midgut    180.3 Adult Hindgut    176.2 Adult Malpighian Tubules    279.5 Adult Fat Body    207 Adult Salivary Gland    221.6 Adult Heart    186.375 Adult VirginFemale Spermatheca    407.5 Adult InseminatedFemale Spermatheca    459.9 Adult Ovary    490.3 Adult Testis    334.1 Adult Male Accessory Gland    126.6 Adult Carcass    135.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    409.225 Larval Midgut    171.9 Larval Hindgut    217.1 Larval Malpighian Tubules    292.4 Larval Fat Body    379.5 Larval Salivary Gland    550.4 Larval Trachea    269.875 Larval Carcass    300.325 Adult Head    153.2 Adult Eye    225.65 Adult Brain    239.7 Adult Thoracic-Abdominal Ganglion    219.8 Adult Crop    211.8 Adult Midgut    180.3 Adult Hindgut    176.2 Adult Malpighian Tubules    279.5 Adult Fat Body    207 Adult Salivary Gland    221.6 Adult Heart    186.375 Adult VirginFemale Spermatheca    407.5 Adult InseminatedFemale Spermatheca    459.9 Adult Ovary    490.3 Adult Testis    334.1 Adult Male Accessory Gland    126.6 Adult Carcass    135.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    409.225 Larval Midgut    171.9 Larval Hindgut    217.1 Larval Malpighian Tubules    292.4 Larval Fat Body    379.5 Larval Salivary Gland    550.4 Larval Trachea    269.875 Larval Carcass    300.325 Adult Head    153.2 Adult Eye    225.65 Adult Brain    239.7 Adult Thoracic-Abdominal Ganglion    219.8 Adult Crop    211.8 Adult Midgut    180.3 Adult Hindgut    176.2 Adult Malpighian Tubules    279.5 Adult Fat Body    207 Adult Salivary Gland    221.6 Adult Heart    186.375 Adult VirginFemale Spermatheca    407.5 Adult InseminatedFemale Spermatheca    459.9 Adult Ovary    490.3 Adult Testis    334.1 Adult Male Accessory Gland    126.6 Adult Carcass    135.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041171 expression level Tissue   Expression Level Larval Central Nervous System    409.225 Larval Midgut    171.9 Larval Hindgut    217.1 Larval Malpighian Tubules    292.4 Larval Fat Body    379.5 Larval Salivary Gland    550.4 Larval Trachea    269.875 Larval Carcass    300.325 Adult Head    153.2 Adult Eye    225.65 Adult Brain    239.7 Adult Thoracic-Abdominal Ganglion    219.8 Adult Crop    211.8 Adult Midgut    180.3 Adult Hindgut    176.2 Adult Malpighian Tubules    279.5 Adult Fat Body    207 Adult Salivary Gland    221.6 Adult Heart    186.375 Adult VirginFemale Spermatheca    407.5 Adult InseminatedFemale Spermatheca    459.9 Adult Ovary    490.3 Adult Testis    334.1 Adult Male Accessory Gland    126.6 Adult Carcass    135.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    409.225 Larval Midgut    171.9 Larval Hindgut    217.1 Larval Malpighian Tubules    292.4 Larval Fat Body    379.5 Larval Salivary Gland  550.4 Larval Trachea    269.875 Larval Carcass    300.325 Adult Head    153.2 Adult Eye    225.65 Adult Brain    239.7 Adult Thoracic-Abdominal Ganglion    219.8 Adult Crop    211.8 Adult Midgut    180.3 Adult Hindgut    176.2 Adult Malpighian Tubules    279.5 Adult Fat Body    207 Adult Salivary Gland    221.6 Adult Heart    186.375 Adult VirginFemale Spermatheca    407.5 Adult InseminatedFemale Spermatheca    459.9 Adult Ovary    490.3 Adult Testis    334.1 Adult Male Accessory Gland    126.6 Adult Carcass    135.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    409.225 Larval Midgut    171.9 Larval Hindgut    217.1 Larval Malpighian Tubules    292.4 Larval Fat Body    379.5 Larval Salivary Gland    550.4 Larval Trachea    269.875 Larval Carcass    300.325 Adult Head    153.2 Adult Eye    225.65 Adult Brain    239.7 Adult Thoracic-Abdominal Ganglion    219.8 Adult Crop    211.8 Adult Midgut    180.3 Adult Hindgut    176.2 Adult Malpighian Tubules    279.5 Adult Fat Body    207 Adult Salivary Gland    221.6 Adult Heart    186.375 Adult VirginFemale Spermatheca    407.5 Adult InseminatedFemale Spermatheca    459.9 Adult Ovary    490.3 Adult Testis    334.1 Adult Male Accessory Gland    126.6 Adult Carcass    135.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    409.225 Larval Midgut    171.9 Larval Hindgut    217.1 Larval Malpighian Tubules    292.4 Larval Fat Body    379.5 Larval Salivary Gland    550.4 Larval Trachea    269.875 Larval Carcass    300.325 Adult Head    153.2 Adult Eye    225.65 Adult Brain    239.7 Adult Thoracic-Abdominal Ganglion    219.8 Adult Crop    211.8 Adult Midgut    180.3 Adult Hindgut    176.2 Adult Malpighian Tubules    279.5 Adult Fat Body    207 Adult Salivary Gland    221.6 Adult Heart    186.375 Adult VirginFemale Spermatheca    407.5 Adult InseminatedFemale Spermatheca    459.9 Adult Ovary    490.3 Adult Testis    334.1 Adult Male Accessory Gland    126.6 Adult Carcass    135.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    153.2   NA  Eye    225.65   NA  Brain    239.7   409.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    219.8   NA  Crop    211.8   171.9  Midgut    180.3   217.1  Hindgut    176.2   292.4  Malpighian Tubules    279.5   379.5  Fat Body    207   550.4  Salivary Gland    221.6   NA  Heart    186.375   269.875  Trachea    NA   NA  VirginFemale Spermatheca    407.5   NA  InseminatedFemale Spermatheca    459.9   NA  Ovary    490.3   NA  Testis    334.1   NA  Male Accessory Gland    126.6   300.325  Carcass    135.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041171 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15010-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal agoEY01092 Other Phenotypes Allele decreased cell size, with Scer\GAL4en-e16E agoΔN.Scer\UAS increased cell number | somatic clone ago1 ago3 ago4 mitotic cell cycle defective | somatic clone ago3 agounspecified neuroanatomy defective | somatic clone | third instar larval stage agoF387 small body, with Scer\GAL4en-e16E agoΔN.Scer\UAS visible | recessive | somatic clone ago1 Phenotype manifest in Allele eye | somatic clone ago1 follicle cell & nucleus | somatic clone agounspecified interommatidial bristle | ectopic | somatic clone ago3 mitotic cell cycle | somatic clone ago3 nurse cell & nucleus | germ-line clone ago1 ago4 nurse cell | germline clone ago1 ago4 RP2 neuron | ectopic ago1 ago3 RP2 neuron | ectopic (with Df(3L)GN50) ago3 secondary pigment cell | ectopic | somatic clone ago3 tertiary pigment cell | ectopic | somatic clone ago3 wing | posterior compartment, with Scer\GAL4en-e16E agoΔN.Scer\UAS wing disc | somatic clone ago1
Classical Alleles ( 24 )
For All Classical Alleles Show
Allele of ago Class Mutagen Stocks Known lesion ago5-HA-2760 1 -- agod09378 1 -- agod10145 P-element activity 1 -- agod11744 1 -- agoEP1135 P-element activity 1 -- agoEY01092 P-element activity 1 -- agoNP0850 1 -- ago1 ethyl methanesulfonate 0 Yes ago3 ethyl methanesulfonate 0 Yes ago4 ethyl methanesulfonate 0 Yes agod04399 0 -- agod05878 0 -- agod06641 P-element activity 0 -- agod08894 0 -- agod09187 0 -- agod09226 P-element activity 0 -- agod09259 P-element activity 0 -- agod10246 0 -- agod10735 0 -- agod11171 P-element activity 0 -- agod11501 P-element activity 0 -- agod11572 P-element activity 0 -- agoF387 ethyl methanesulfonate 0 Yes agounspecified 0 --
Alleles Carried on Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ago Class Mutagen Stocks Known lesion agoHM04005 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes agoHMS00111 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ago1.IE1.T:Sjap\GST in vitro construct 0 Yes ago1.MtnA.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes ago3.IE1.T:Sjap\GST in vitro construct 0 Yes ago3.MtnA.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes agodsRNA.C in vitro construct - RNAi 0 Yes agodsRNA.cKa in vitro construct - RNAi 0 Yes agodsRNA.cMa in vitro construct - RNAi 0 Yes agodsRNA.Fbox in vitro construct - RNAi 0 Yes agodsRNA.N in vitro construct - RNAi 0 Yes agoGD1360 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes agoIE1.T:Sjap\GST in vitro construct - deletion in vitro construct - coding region fusion 0 Yes agoMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes agoMtnA.T:SV5\V5 in vitro construct - coding region fusion 0 Yes agoScer\UAS.T:Avic\GFP-YFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes agoΔF.MtnA.T:Ivir\HA1 in vitro construct - deletion 0 Yes agoΔN.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel9000 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1360} NA P{TRiP.HM04005} NA P{TRiP.HMS00111} NA P{UAS-ago.YFP} NA P{UAS-ago.ΔN} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}agoEP1135 NA P{EPgy2}agoEY01092 NA P{XP}agod04399 NA P{XP}agod05878 NA P{XP}agod06641 NA P{XP}agod08894 NA P{XP}agod09187 NA P{XP}agod09226 NA P{XP}agod09259 NA P{XP}agod09378 NA P{XP}agod10145 NA P{XP}agod10246 NA P{XP}agod10735 NA P{XP}agod11171 NA P{XP}agod11501 NA P{XP}agod11572 NA P{XP}agod11744 NA insertion of enhancer trap binary system P{GawB}agoNP0850 No miscellaneous insertions P{RS5}ago5-HA-2760 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Berger et al., 2008) DNA endoreduplication inferred from mutant phenotype (Shcherbata et al., 2004) negative regulation of glial cell proliferation inferred from genetic interaction with slmb (Ho et al., 2009) negative regulation of growth inferred from mutant phenotype (Moberg et al., 2004) regulation of mitosis inferred from mutant phenotype (Moberg et al., 2001)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
cyclin binding traceable author statement (Lee and Orr-Weaver, 2003) ubiquitin-protein ligase activity inferred from sequence or structural similarity with Saccharomyces CDC4 (FlyBase, 1992-)
Biological Process
CV term Evidence References
cyclin catabolic process traceable author statement (Moberg et al., 2001) regulation of exit from mitosis traceable author statement (Lee and Orr-Weaver, 2003) regulation of proteolysis traceable author statement (Lee and Orr-Weaver, 2003)
Cellular Component
CV term Evidence References
SCF ubiquitin ligase complex non-traceable author statement (Ou et al., 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ago allele Gene References ago1 dm (Moberg et al., 2004) ago3 CycE (Moberg et al., 2001) ago4 CSN5 (Doronkin et al., 2003) agoEP1135 btl::Egfr (Zhu et al., 2005) Pvr (Zhu et al., 2005) agounspecified CSN4 (Doronkin et al., 2003) CycE (Brumby et al., 2004) unspecified dap (Moberg et al., 2001) dm (Secombe et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63994 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041171 DroID - A comprehensive database of gene and protein interactions. • FBgn0041171 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38516
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23871 Dere\GG14203 Dgri\anon-2 Dmoj\GI16816 Dper\GL12727 Dpse\GA13429 Dsec\GM13994 Dsim\GD13273 Dvir\GJ12563 Dwil\GK10570 Dyak\GE20631
Curated drosophilid orthologs	Dpse\GA13429
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011215-PA Aedes aegypti (mosquito) AGAP005359-PA Anopheles gambiae (mosquito) XP_396532.3 Apis mellifera (honey bee) XP_001950576.1 Acyrthosiphon pisum (pea aphid) At1g49040.1 Arabidopsis thaliana (wall cress) XP_001894040.1 Brugia malayi (roundworm nematode) ENSBTAP00000025393 Bos taurus (bovine) CN30387 Caenorhabditis brenneri (small nematode) ENSCAFP00000011996 Canis familiaris (dog) CMD010C Cyanidioschyzon merolae (red alga) CPIJ011984 Culex pipens (mosquito) CPIJ012122 Culex pipens (mosquito) ENSCPOP00000010651 Cavia porcellus (guinea pig) DDB0235330 Dictyostelium discoideum (amoeba) ENSP00000281708 Homo sapiens (human) 38432 Monocosta brevicollis (choanoflagellate) ENSMODP00000019895 Monodelphis domestica (gray opossum) ENSMMUP00000026757 Macaca mulatta (rhesus monkey) ENSMUSP00000103306 Mus musculus (house mouse) ENSOANP00000008405 Ornithorynchus anatinus (platypus) 101282 Physcomitrella patens (moss) ENSPPYP00000007911 Pongo pygmaeus (orangutan) 74433 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000028353 Pan troglodytes (chimpanzee) 4761931 Sorghum bicolor (sorghum) YFL009W Saccharomyces cerevisiae (budding yeast) XP_001182658.1 Strongylocentrotus purpuratus (purple sea urchin) 52993 Trichoplax adhaerens (metazoa) TA13035 Theileria annulata (apicomplexan parasite) ENSTNIP00000017024 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039022 Takifugu rubripes (pufferfish Takifugu) 3706.m00120 Tetrahymena thermophila (ciliate protozoa) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10030 LH11801 ISCW017325 FBgn0237936 FBgn0212585 FBgn0199803 FBgn0184993 FBgn0168923 JGI_V11_50336 FBgn0073465 FBgn0150333 FBgn0139563 FBgn0020171 FBgn0106464 FBgn0100865 CPIJ012122 CPIJ011984 BGIBMGA012355 ACYPI007103 ACYPI004580 GB17249 AGAP005359 AAEL011215 PB24556 PHUM539800 GLEAN_06451
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	31501 y1 v1; P{TRiP.HM04005}attP2 16989 w1118; P{EP}agoEP1135/TM6B, Tb1 34802 y1 sc* v1; P{TRiP.HMS00111}attP2 20064 y1 w67c23; P{EPgy2}agoEY01092/TM3, Sb1 Ser1
Harvard	- P{XP}agod09378 - P{XP}agod10145 - P{XP}agod11744
Kyoto	125656 w1118; P{RS5}ago5-HA-2760 103788 w*; P{GawB}agoNP0850 / TM3, Ser1
Genomic Clones ( 2 )
	BACR39O11 BACR48M07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 88 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21322 LD30271
Other clones	DPiM_LD21322
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH11648 GH26540 LD01377 LD01816 LD02968 LD05246 LD06149 LD09576 LD10375 LD10974 LD12088 LD12324 LD14869 LD18809 LD18934 LD19075 LD20079 LD23732 LD25157 LD26025 LD26530 LD27029 LD30515 LD30542 LD31256 LD31470 LD41775 LD43696 LD44442 LD45995 LD46308 LD46948 LP22305 RE04356 RE10337 RE13020 RE16139 RE33414 RE36301 RE39770 RE41423 RE42348 RE42871 RE45775 RE62391 RE62991 RE68136 RE68233 RE70596 SD19671
Other clones	13157 46401 47309 57569 63938 83690 107106 122750 158154 214249.18 214353.20 214417.20 214537.22 bs41b03 bs46b04 CK01.8A.F7 Dmel_dig_012183_0716_1633 Dmel_neb_012006_0582_1092 Dmel_neb_012191_0332_2522 EC052380 EC053438 EK010924 EK054641 EK115145 EK165417 EK172509 EK244104 EK252801 EK299908 EP02825 EP06441 EP17811 EP21647 LD19987 LD45270
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041171 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38516
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: ago anon-WO0118547.345 (FlyBase, 1996-) Source for merge of: ago CG15010 (Moberg et al., 2001)
Additional comments	Source for merge of ago anon-WO0118547.345 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Pilot et al., 2006) Mutants in ago show increased tissue growth. (Moberg et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila EST AA392932 (inverted). (Davies, 2001.3.15) ago is involved in developmental regulation of CycE degradation. (Moberg et al., 2001) Clones of mutant cells in the eye disc result in cell fate changes and overrepresentation of mutant cells in the eye. (Moberg and Hariharan, 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079198 NM_168072 NM_168073 RefSeq (Proteins) • NP_523922 NP_728964 NP_728965 DDBJ / EMBL / GenBank • AA392932 AA735443 AA950467 AAF47869 AAG22246 AAG22247 AAL28848 AAL68231 AW942590 AW943018 AX094221 AY061300 AY075401 CL706557 CZ475261 CZ476624 CZ476644 CZ477125 CZ477597 CZ477768 CZ477810 Entrez Gene - A searchable database of RefSeq genes. • 38516 UniProtKB/TrEMBL • Q9VZF4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) F-box domain, cyclin-like (IPR001810) WD40 repeat-like-containing domain (IPR011046) WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472) F-box domain, Skp2-like (IPR022364)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63994 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041171 DroID - A comprehensive database of gene and protein interactions. • FBgn0041171 DRSC - Results from RNAi screens. • FBgn0041171 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041171 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15010-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041171 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38516 InParanoid A subset of ortholog calls from InParanoid. • AAEL011215-PA Aedes aegypti (mosquito) AGAP005359-PA Anopheles gambiae (mosquito) XP_396532.3 Apis mellifera (honey bee) XP_001950576.1 Acyrthosiphon pisum (pea aphid) At1g49040.1 Arabidopsis thaliana (wall cress) XP_001894040.1 Brugia malayi (roundworm nematode) ENSBTAP00000025393 Bos taurus (bovine) CN30387 Caenorhabditis brenneri (small nematode) ENSCAFP00000011996 Canis familiaris (dog) CMD010C Cyanidioschyzon merolae (red alga) CPIJ011984 Culex pipens (mosquito) CPIJ012122 Culex pipens (mosquito) ENSCPOP00000010651 Cavia porcellus (guinea pig) DDB0235330 Dictyostelium discoideum (amoeba) ENSP00000281708 Homo sapiens (human) 38432 Monocosta brevicollis (choanoflagellate) ENSMODP00000019895 Monodelphis domestica (gray opossum) ENSMMUP00000026757 Macaca mulatta (rhesus monkey) ENSMUSP00000103306 Mus musculus (house mouse) ENSOANP00000008405 Ornithorynchus anatinus (platypus) 101282 Physcomitrella patens (moss) ENSPPYP00000007911 Pongo pygmaeus (orangutan) 74433 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000028353 Pan troglodytes (chimpanzee) 4761931 Sorghum bicolor (sorghum) YFL009W Saccharomyces cerevisiae (budding yeast) XP_001182658.1 Strongylocentrotus purpuratus (purple sea urchin) 52993 Trichoplax adhaerens (metazoa) TA13035 Theileria annulata (apicomplexan parasite) ENSTNIP00000017024 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039022 Takifugu rubripes (pufferfish Takifugu) 3706.m00120 Tetrahymena thermophila (ciliate protozoa) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/archipelago1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38516 modMine - Data generated by the modENCODE project. • FBgn0041171 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10030 LH11801 ISCW017325 FBgn0237936 FBgn0212585 FBgn0199803 FBgn0184993 FBgn0168923 JGI_V11_50336 FBgn0073465 FBgn0150333 FBgn0139563 FBgn0020171 FBgn0106464 FBgn0100865 CPIJ012122 CPIJ011984 BGIBMGA012355 ACYPI007103 ACYPI004580 GB17249 AGAP005359 AAEL011215 PB24556 PHUM539800 GLEAN_06451
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	ago (Tyler et al., 2007, Mortimer and Moberg, 2007, Secombe et al., 2007, Ho et al., 2008, Firth and Baker, 2005, Mortimer and Moberg, 2007, Rhiner et al., 2009, Ho et al., 2009, Szuplewski et al., 2009, Nicholson et al., 2009, Magalhaes et al., 2007, Zhou et al., 2008, Nicholson et al., 2011) Ago (Galletti et al., 2007, Martin et al., 2007, Shibutani et al., 2008) anon-WO0118547.345   cdc4 (Brumby et al., 2004) CG15010 (Halfon et al., 2002, Das et al., 2002, Koepp et al., 2001, Pilot et al., 2006, Gandhi et al., 2007, Berger et al., 2008, Ni et al., 2008, Ni et al., 2011.7.19) DmFbw7 (Koepp et al., 2001) SCFAgo (Mortimer and Moberg, 2005)
Name Synonym	archipelago (Moberg and Hariharan, 2000, Mortimer and Moberg, 2007, Tountas and Fortini, 2007, Rhiner et al., 2009, Szuplewski et al., 2009, Nicholson et al., 2009, Berger et al., 2008, Mandal et al., 2010) Archipelago (Galletti et al., 2007, Secombe et al., 2007, Mortimer and Moberg, 2007, Ho et al., 2009)
Secondary FlyBase IDs
	FBgn0035516 FBgn0062079
References ( 69 )
Generate a list of	All references relating to this gene ( 69 )
List References by type	Research paper  ( 32 ) Supplementary material  ( 4 ) Review  ( 7 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 12 ) FlyBase analysis  ( 3 ) Conference report  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Nicholson et al., 2011, Development 138(2): 251--260 Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. [FBrf0212669] Mandal et al., 2010, J. Cell Biol. 188(4): 473--479 Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome system. [FBrf0210063] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...