Gene model reviewed during 5.45
Part of a complex with Cul2, Roc1a/Rbx1 and the elongin BC complex. Interacts with sima/Hif1a. Interacts with itself. Interacts with mgr and betaTub56D/tubulin beta-1 chain. Interacts with tubulin alpha-beta heterodimers by itself or in complex with mgr. Interacts with microtubules (MTs).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vhl using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Vhl in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
10% of embryos treated with Vhl dsRNA (to induce RNAi) reveal a narrow gap in the denticle pattern along the ventral midline.
Vhl is required for halting cell migration and tube outgrowth at the end of the tracheal tube formation.
Loss of function mutations in Vhl show ectopic branching and looping in the tracheal system accompanied by breakage in the main trunk.