FB2021_01, released Feb 18, 2021

Gene: Dmel\Tep4

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General Information
Symbol
Dmel\Tep4
Species
D. melanogaster
Name
Thioester-containing protein 4
Annotation Symbol
CG10363
Feature Type
protein_coding_gene
FlyBase ID
FBgn0041180
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Thioester-containing protein 4 (Tep4) is a member of the Thioester-containing proteins (TEP) family of genes. The product of Tep4 has endopeptidase inhibitor activity and participates in the cellular immune response to certain Gram-negative bacteria. [Date last reviewed: 2019-03-21]
Other Summaries
Also Known As

TepIV, Thiolester containing protein IV, Tep IV, dTEPIV

Key Links
Genomic Location
Cytogenetic map
37F1-37F1
Sequence location
2L:19,548,507..19,556,451 [+]
Recombination map

2-54

RefSeq locus
NT_033779 REGION:19548507..19556451
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables endopeptidase inhibitor activity
inferred from electronic annotation with InterPro:IPR001599, InterPro:IPR002890
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in innate immune response
(Dostálová et al., 2017)
involved_in multicellular organism reproduction
inferred from high throughput expression pattern
(Mueller et al., 2005)
involved_in response to fungus
inferred from high throughput expression pattern
(Levy et al., 2004)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Dostálová et al., 2017)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from sequence model
(Mueller et al., 2005)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Tep4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tep4-RA
FBtr0081254
NM_078879
4694
1496
Tep4-RB
FBtr0331328
NM_001273660
4717
1476
Tep4-RC
FBtr0331329
NM_001273661
4700
1498
Tep4-RD
FBtr0331330
NM_001273662
4723
1478
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Tep4-PA
FBpp0080795
168.5
1496
5.42
NP_523603
AAF53826
Tep4-PB
FBpp0303746
166.4
1476
5.37
NP_001260589
AGB93124
Tep4-PC
FBpp0303747
168.8
1498
5.38
NP_001260590
AGB93125
Tep4-PD
FBpp0303748
166.6
1478
5.33
NP_001260591
AGB93126
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tep4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
fat body/gonad primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval lymph gland
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
third instar larval stage
medullary zone of lymph gland primary lobe
(Makki et al., 2010)
prohemocyte
(Bras et al., 2012)
larval stage
embryonic/larval lymph gland
(Bou Aoun et al., 2011)
plasmatocyte
(Bou Aoun et al., 2011)
embryonic/larval fat body
(Bou Aoun et al., 2011)
adult stage
epithelium of crop
(Bou Aoun et al., 2011)
epidermis of abdomen | ventral
(Bou Aoun et al., 2011)
adult fat body

Comment: head region only

(Bou Aoun et al., 2011)
mesothoracic phragma
(Bou Aoun et al., 2011)
Additional Descriptive Data

Tep4 expression is detected in lymph gland, plasmatocytes and in fat body in larvae. In adults it is observed in the crop epithelium, in the epidermis underlying the cuticle in the abodomen on the ventral side, and in the fat body in the head region. Expression is also detected in the mesothoracic phragma, the structure found at the border between thorax and abdomen and to which flight muscles are attached posteriorly.

(Bou Aoun et al., 2011)
Marker for
 
medullary zone of lymph gland primary lobe
(Makki et al., 2010)
prohemocyte
(Bras et al., 2012)
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Dostálová et al., 2017)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tep4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tep4
Transgenic constructs containing regulatory region of Tep4
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation
Gene disrupted in
Df(2L)Exel8041
(Ryder, 2004.4.26)
Inferred from location
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CD109
11 of 15
Yes
No
Hsap\A2M
5 of 15
No
No
Hsap\A2ML1
5 of 15
No
Yes
Hsap\C5
5 of 15
No
Yes
Hsap\PZP
5 of 15
No
No
Hsap\C3
4 of 15
No
Yes
Hsap\C4A
4 of 15
No
Yes
Hsap\C4B
4 of 15
No
Yes
Hsap\CPAMD8
3 of 15
No
Yes
Hsap\C3P1
1 of 15
No
Yes
Hsap\C4B_2
1 of 15
No
Yes
Hsap\LOC110384692
1 of 15
No
Yes
Hsap\OVOS2
1 of 15
No
Yes
Hsap\OVOS
1 of 15
No
Yes
Hsap\WASHC1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cd109
11 of 15
Yes
No
Mmus\Mug1
6 of 15
No
Yes
Mmus\Mug2
6 of 15
No
Yes
Mmus\A2m
5 of 15
No
No
Mmus\C4b
5 of 15
No
Yes
Mmus\Pzp
5 of 15
No
Yes
Mmus\A2ml1
4 of 15
No
Yes
Mmus\C3
4 of 15
No
Yes
Mmus\Hc
4 of 15
No
Yes
Mmus\AI182371
2 of 15
No
Yes
Mmus\C4a
1 of 15
No
Yes
Mmus\Gm7298
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (17)
Rnor\Cd109
9 of 13
Yes
No
Rnor\C4b
5 of 13
No
Yes
Rnor\Mug1
5 of 13
No
Yes
Rnor\Mug2
5 of 13
No
Yes
Rnor\Pzp
5 of 13
No
Yes
Rnor\A2ml1
4 of 13
No
Yes
Rnor\A2m
4 of 13
No
Yes
Rnor\C4a
4 of 13
No
Yes
Rnor\LOC297568
4 of 13
No
Yes
Rnor\LOC100911545
4 of 13
No
Yes
Rnor\LOC103689965
4 of 13
No
Yes
Rnor\C3
3 of 13
No
Yes
Rnor\C5
2 of 13
No
Yes
Rnor\Cpamd8
2 of 13
No
Yes
Rnor\LOC100911784
2 of 13
No
Yes
Rnor\LOC108348163
2 of 13
No
Yes
Rnor\LOC100911870
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (51)
Xtro\a2ml1
4 of 12
Yes
Yes
Xtro\a2m
4 of 12
Yes
Yes
Xtro\c4a
4 of 12
Yes
Yes
Xtro\c5
4 of 12
Yes
Yes
Xtro\ovos2
4 of 12
Yes
Yes
Xtro\pzp
4 of 12
Yes
Yes
Xtro\c3
3 of 12
No
Yes
Xtro\cd109
2 of 12
No
No
Xtro\LOC619594
2 of 12
No
Yes
Xtro\LOC100487426
2 of 12
No
Yes
Xtro\LOC100487578
2 of 12
No
Yes
Xtro\LOC100487580
2 of 12
No
Yes
Xtro\LOC100487726
2 of 12
No
Yes
Xtro\LOC100487905
2 of 12
No
Yes
Xtro\LOC100488897
2 of 12
No
Yes
Xtro\LOC100489060
2 of 12
No
Yes
Xtro\LOC100491246
2 of 12
No
Yes
Xtro\LOC100494685
2 of 12
No
Yes
Xtro\LOC100495827
2 of 12
No
Yes
Xtro\LOC101730404
2 of 12
No
Yes
Xtro\LOC101730963
2 of 12
No
Yes
Xtro\LOC101731171
2 of 12
No
Yes
Xtro\LOC101732271
2 of 12
No
Yes
Xtro\LOC101732331
2 of 12
No
Yes
Xtro\LOC101732535
2 of 12
No
Yes
Xtro\LOC101734563
2 of 12
No
Yes
Xtro\LOC101734901
2 of 12
No
Yes
Xtro\LOC101734927
2 of 12
No
Yes
Xtro\LOC101735074
2 of 12
No
Yes
Xtro\LOC105947308
2 of 12
No
Yes
Xtro\LOC108645185
2 of 12
No
Yes
Xtro\LOC108645442
2 of 12
No
Yes
Xtro\LOC108647609
2 of 12
No
Yes
Xtro\cpamd8
1 of 12
No
Yes
Xtro\LOC100145246
1 of 12
No
Yes
Xtro\LOC100170611
1 of 12
No
Yes
Xtro\LOC100487748
1 of 12
No
Yes
Xtro\LOC100488238
1 of 12
No
Yes
Xtro\LOC100488566
1 of 12
No
Yes
Xtro\LOC100491357
1 of 12
No
Yes
Xtro\LOC100491968
1 of 12
No
Yes
Xtro\LOC100492134
1 of 12
No
Yes
Xtro\LOC101730342
1 of 12
No
Yes
Xtro\LOC105945508
1 of 12
No
Yes
Xtro\LOC105945509
1 of 12
No
Yes
Xtro\LOC105945599
1 of 12
No
Yes
Xtro\LOC108644460
1 of 12
No
Yes
Xtro\LOC108644496
1 of 12
No
Yes
Xtro\LOC108644864
1 of 12
No
Yes
Xtro\LOC108646250
1 of 12
No
Yes
Xtro\LOC108647630
1 of 12
No
Yes
Danio rerio (Zebrafish) (32)
Drer\cd109
10 of 15
Yes
No
Drer\si:dkey-46g23.2
7 of 15
No
Yes
Drer\a2ml
6 of 15
No
No
Drer\si:dkey-46g23.5
6 of 15
No
Yes
Drer\zgc:165518
6 of 15
No
Yes
Drer\c3a.4
5 of 15
No
Yes
Drer\c3b.1
5 of 15
No
Yes
Drer\c3b.2
5 of 15
No
Yes
Drer\c4b
5 of 15
No
Yes
Drer\c4
5 of 15
No
Yes
Drer\c5
5 of 15
No
Yes
Drer\si:ch211-212c13.10
5 of 15
No
Yes
Drer\si:dkey-105h12.2
5 of 15
No
Yes
Drer\zgc:165453
5 of 15
No
Yes
Drer\zgc:171426
5 of 15
No
Yes
Drer\zgc:171445
5 of 15
No
Yes
Drer\zgc:171446
5 of 15
No
Yes
Drer\c3a.2
4 of 15
No
Yes
Drer\LOC103909927
4 of 15
No
Yes
Drer\c3a.3
3 of 15
No
Yes
Drer\c3a.6
3 of 15
No
Yes
Drer\cpamd8
3 of 15
No
Yes
Drer\LOC108179231
3 of 15
No
Yes
Drer\sb:cb37
3 of 15
No
Yes
Drer\si:dkey-52d15.2
3 of 15
No
Yes
Drer\c3a.1
2 of 15
No
Yes
Drer\LOC407643
2 of 15
No
Yes
Drer\LOC569025
2 of 15
No
Yes
Drer\LOC100006895
2 of 15
No
Yes
Drer\LOC101886227
2 of 15
No
Yes
Drer\LOC792509
1 of 15
No
Yes
Drer\LOC103909957
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\tep-1
9 of 15
Yes
No
Cele\F13D2.1
2 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900I4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001017
Drosophila simulans
Dsim\Tep4
Drosophila sechellia
Dsec\Tep4
Drosophila erecta
Dere\Tep4
Drosophila yakuba
Dyak\Tep4
Drosophila ananassae
Dana\Tep4
Drosophila pseudoobscura pseudoobscura
Dpse\Tep4
Drosophila persimilis
Dper\Tep4
Drosophila willistoni
Dwil\Tep4
Drosophila virilis
Dvir\Tep4
Drosophila mojavensis
Dmoj\Tep4
Drosophila mojavensis
Dmoj\GI11285
Drosophila mojavensis
Dmoj\Tep5
Drosophila grimshawi
Dgri\Tep4
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500HN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023263
Musca domestica
House fly
Mdoa\17019274
Musca domestica
House fly
Mdoa\17004779
Musca domestica
House fly
Mdoa\17005757
Musca domestica
House fly
Mdoa\17023265
Musca domestica
House fly
Mdoa\17023268
Glossina morsitans
Tsetse fly
Gmor\GMOY008955
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00372
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04083
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01MA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012631
Bombyx mori
Silkmoth
Bmor\BGIBMGA013565
Danaus plexippus
Monarch butterfly
Dple\DPOGS215836-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206012-PA
Heliconius melpomene
Postman butterfly
Hmel\TEP-A
Heliconius melpomene
Postman butterfly
Hmel\TEP-B
Apis florea
Little honeybee
Aflo\2224273956
Apis florea
Little honeybee
Aflo\2555464260
Apis mellifera
Western honey bee
Amel\TEP7
Apis mellifera
Western honey bee
Amel\GB45417
Apis mellifera
Western honey bee
Amel\GB42916
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24442
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19795
Bombus terrestris
Buff-tailed bumblebee
Bter\15212049
Bombus terrestris
Buff-tailed bumblebee
Bter\15209808
Linepithema humile
Argentine ant
Lhum\LH26214
Linepithema humile
Argentine ant
Lhum\LH26167
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000be5
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002e5d
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014366
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002345
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10024
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04876
Tribolium castaneum
Red flour beetle
Tcas\TC033599
Tribolium castaneum
Red flour beetle
Tcas\TC014664
Pediculus humanus
Human body louse
Phum\PHUM375050
Pediculus humanus
Human body louse
Phum\PHUM289710
Rhodnius prolixus
Kissing bug
Rpro\RPRC006447
Cimex lectularius
Bed bug
Clec\CLEC005127
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005292
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18586
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02879
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01KB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009298
Strigamia maritima
European centipede
Smar\SMAR006272
Strigamia maritima
European centipede
Smar\SMAR006270
Ixodes scapularis
Black-legged tick
Isca\ISCW003923
Ixodes scapularis
Black-legged tick
Isca\ISCW020822
Ixodes scapularis
Black-legged tick
Isca\ISCW023777
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65270.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64970.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80120.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80556.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g02040
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_61510
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300552
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_313404
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00F8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Gallus gallus
Domestic chicken
Ggal\CD109
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Tep1
7 of 10
Tep2
7 of 10
Tep3
7 of 10
Tep5Ψ
5 of 10
Mcr
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 6 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CD109; CD109 molecule
    11 of 15
    608859
        A2M; alpha-2-macroglobulin
        5 of 15
        103950
        A2ML1; alpha-2-macroglobulin like 1
        5 of 15
        610627
          C5; complement C5
          5 of 15
          120900
          PZP; PZP alpha-2-macroglobulin like
          5 of 15
          176420
              C3; complement C3
              4 of 15
              120700
              C4A; complement C4A (Rodgers blood group)
              4 of 15
              120810
              C4B; complement C4B (Chido blood group)
              4 of 15
              120820
              CPAMD8; C3 and PZP like alpha-2-macroglobulin domain containing 8
              3 of 15
              608841
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement
              View in Interactions Browser
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Ras85D
              enhanceable
              Tep4
              (Friedman et al., 2011)
              External Data
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              External Data
              Linkouts
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2L
              Recombination map

              2-54

              Cytogenetic map
              37F1-37F1
              Sequence location
              2L:19,548,507..19,556,451 [+]
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              37F1-37F1
              Limits computationally determined from genome sequence between P{EP}EP623&P{PZ}spi01068 and P{lacW}l(2)k10239k10239
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              37F1-37F2
              (Lagueux, 2000.3.15, Lagueux, 2000.4.11)
              Experimentally Determined Recombination Data
              Location

              2-54

              (FlyBase, 2016)

              2-53.7

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (8)
              Genomic Clones (10)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (24)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Tep4 TepIV

                  (Bou Aoun et al., 2011)
                  Source for database merge of

                  Source for merge of: TepIV CG10363

                  (FlyBase, 1996-)
                  Additional comments

                  Source for merge of TepIV CG10363 was sequence comparison ( date:000423 ).

                  (FlyBase, 1996-)
                  Other Comments

                  S2 cells treated with dsRNA generated against this gene show similar levels of phagocytosis of Candida albicans, Escherichia coli and Staphylococcus aureus as untreated cells.

                  (Stroschein-Stevenson et al., 2006)

                  Isolated in a screen for seminal fluid proteins.

                  (Mueller et al., 2004)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 52 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (17)
                  Reported As
                  Symbol Synonym
                  CG10363
                  (Wong et al., 2012, Bou Aoun et al., 2011, Giardina et al., 2011, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Heger and Ponting, 2007, Pal et al., 2007, Stroschein-Stevenson et al., 2006, Mueller et al., 2005, Wertheim et al., 2005, Levy et al., 2004, Mueller et al., 2004, Kocks et al., 2003, De Gregorio et al., 2001)
                  CT29102
                  (Ceriani et al., 2002)
                  TEP IV
                  (Pal et al., 2007)
                  TEP4
                  (Arefin et al., 2014, Bou Aoun et al., 2011)
                  TEP4mel
                  (Bou Aoun et al., 2011)
                  TEPIV
                  (Castillo et al., 2015, Telonis-Scott et al., 2013)
                  Tep IV
                  (Taylor et al., 2014, Igboin et al., 2012)
                  Tep4
                  (Cho et al., 2020, Lu et al., 2020, Vásquez-Procopio et al., 2020, Harbison et al., 2019, Melcarne et al., 2019, Sharma et al., 2019, Haller et al., 2018, Troha et al., 2018, Yu et al., 2018, Dostálová et al., 2017, Shokal and Eleftherianos, 2017, Shokal and Eleftherianos, 2017, Yang and Veraksa, 2017, Gene Disruption Project members, 2016-, Hosamani et al., 2016, Kavi et al., 2015, Kwon et al., 2013, Bou Aoun et al., 2011, Makki et al., 2010, Bou Aoun et al., 2008, Waterhouse et al., 2007, De Gregorio et al., 2002, De Gregorio et al., 2001, Lagueux, 2000.4.11, Lagueux et al., 2000)
                  TepIV
                  (Nguyen et al., 2016, Evans et al., 2014, Salazar-Jaramillo et al., 2014, Gendrin et al., 2013, Kwon et al., 2013, Wang et al., 2013, Doroszuk et al., 2012, Felix et al., 2012, Rettie and Dorus, 2012, Wong et al., 2012, Friedman et al., 2011, Friedman et al., 2011, Friedman et al., 2011, Karpac et al., 2011, Wong et al., 2011, Stofanko et al., 2010, Wasbrough et al., 2010, Buchon et al., 2009, Obbard et al., 2009, Kwon et al., 2008, Akdemir et al., 2007, Heger and Ponting, 2007, Ravi Ram and Wolfner, 2007, Sackton et al., 2007, Jiggins and Kim, 2006, Stroschein-Stevenson et al., 2006, Wertheim et al., 2005, Levy et al., 2004, Christophides et al., 2002)
                  dTEPIV
                  (Lagueux, 2000.3.15, Lagueux et al., 2000)
                  tep4
                  (Morin-Poulard et al., 2013, Krzemień et al., 2007)
                  tepIV
                  (Bras et al., 2012, Igboin et al., 2011, Avet-Rochex et al., 2010)
                  Name Synonyms
                  TEP
                  (Erturk-Hasdemir and Silverman, 2005)
                  Thioester containing protein IV
                  (Taylor et al., 2014)
                  Thioester-containing protein 4
                  Thioester-containing protein4
                  (Yu et al., 2018)
                  Thiolester containing protein IV
                  (Felix et al., 2012, Lagueux et al., 2000)
                  Secondary FlyBase IDs
                  • FBgn0032806
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (121)