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Gene Dmel\Tep2

General Information
Symbol	Dmel\Tep2	Species	D. melanogaster
Name	Thioester-containing protein 2	Annotation symbol	CG7052
Feature type	protein_coding_gene	FlyBase ID	FBgn0041182
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	TepII, Tep2, dTEPII, CG18589, TEP II
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	28C1-28C1	Sequence location	2L:7,693,727..7,701,601 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Thioester-containing protein 2 is referred to in FlyBase by the symbol Dmel\Tep2 (CG7052, FBgn0041182). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: peptidase inhibitor activity. There is experimental evidence that it is involved in the biological process: defense response to Gram-negative bacterium; antibacterial humoral response; phagocytosis, engulfment. 6 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: A-macroglobulin complement component; Alpha-2-macroglobulin; Alpha-2-macroglobulin, N-terminal; Alpha-2-macroglobulin, N-terminal 2; Alpha-2-macroglobulin, conserved site; Alpha-2-macroglobulin, thiol-ester bond-forming; Alpha-macroglobulin, receptor-binding; Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval hindgut, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval midgut, adult hindgut, adult salivary gland, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1630067_a_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of TepII. Gene sequence location is 2L:7693727..7701601.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Tep2[MI01299]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 28C1-28C1   Limits computationally determined from genome sequence between P{EP}EP2419EP2419&P{EP}EP575 and P{PZ}l(2)rL220rL220
Experimentally Determined Cytological Location
Cytogenetic map Notes References 28B1-28B4     (Lagueux, 2000.4.11) 28B1-28B4     (Lagueux, 2000.3.15)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tep2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tep2-RA FBtr0079510  NM_078782   4539   1420 Tep2-RB FBtr0079511  NM_164761   4476   1399 Tep2-RD FBtr0079513  NM_164764   4503   1408 Tep2-RF FBtr0335487  NM_164763   4564   1400 Tep2-RG FBtr0335488  NM_164762   4591   1409
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tep2-PA   FBpp0079133   158.3   1420   6.50     NP_523506   AAF52541 Tep2-PB   FBpp0079134   155.8   1399   6.24     NP_723298   AAF52539 Tep2-PD   FBpp0079136   156.6   1408   5.40     NP_723301   AAN10640 Tep2-PF   FBpp0307460   155.6   1400   5.46     NP_723300   AAN10639 Tep2-PG   FBpp0307461   156.4   1409   5.83     NP_723299   AAF52540
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Alpha-2-macroglobulin, N-terminal (IPR002890) Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (IPR008930) Alpha-macroglobulin, receptor-binding (IPR009048) Alpha-2-macroglobulin, N-terminal 2 (IPR011625) A-macroglobulin complement component (IPR011626) Alpha-2-macroglobulin, conserved site (IPR019742) Alpha-2-macroglobulin, thiol-ester bond-forming (IPR019565) Alpha-2-macroglobulin (IPR001599)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698235   AA698572   AA699017   AE014134 AAF52539   AE014134 AAF52540   AE014134 AAF52541   AE014134 AAN10639   AE014134 AAN10640   AI062586   AI109290   AI258949   AI533644   AI534860   AJ269539 CAB87808   AY118302 AAM48331   AY122084 AAM52596   AY231685   CA803545   CA803760   CA803950   CA804003   CA804316   CA804553   CA804612   CA804735   CA805004   CA805913   CA806199   CA806231   CA806417   CA806428   CA806496   CA806819   CA807244   CA807258   CA807416   CA807490   CA807831   CO156248   CO176979   CO187726   CO191307   CO194102   CO195805   CO270278   CO273036   CO274175   CO274426   CO285633   CO287012   CO288037   CO293083   CO297086   CO301055   CO322872   CO327102   CO336186   CO337232   CO340050   CZ485304   CZ485305   EC058630   EC059370   EC064408   EC074119   EC075167   EC080540   EC200020   EC220750   EC223475   EC225918   EC230129   EC232600   EC240994   EC241564   EC243953   EC253315   EC253789   EC262112   EC262306   EC263355   EL884949   EL885073   EL885195   GH941696   GH942241   GH944471   GH951171   GH951620   GH954203   GH954738   GH954744   GH955010   GH955502   GH957336   GH957926   GH961528   GH965937   GH968101   GH969167   GH971884   GH973968   GH975137   GH975499   GH976442   GH977581   GH978462   GH978494   GH980438
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IPH4 Q9NFV7 Q9VLY9 Q8MT94 Q9VLZ0 Q8IPH5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 10   yolk nucleus   (Fisher et al., 2012) embryonic stage 11 -- 12   procrystal cell   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   crystal cell   (Fisher et al., 2012) embryonic/larval corpus allatum   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval hindgut, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval midgut, adult hindgut, adult salivary gland, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    129.775 Larval Midgut    107.8 Larval Hindgut    539.8 Larval Malpighian Tubules    41.6 Larval Fat Body    3535.3 Larval Salivary Gland    66.8 Larval Trachea    314.275 Larval Carcass    171.725 Adult Head    929.2 Adult Eye    397.35 Adult Brain    175.7 Adult Thoracic-Abdominal Ganglion    189.1 Adult Crop    78.2 Adult Midgut    23.5 Adult Hindgut    235.3 Adult Malpighian Tubules    28 Adult Fat Body    1150.9 Adult Salivary Gland    438.2 Adult Heart    583.45 Adult VirginFemale Spermatheca    2285 Adult InseminatedFemale Spermatheca    1682.3 Adult Ovary    9.5 Adult Testis    60.7 Adult Male Accessory Gland    12.4 Adult Carcass    710.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    129.775 Larval Midgut    107.8 Larval Hindgut  (539.8) Larval Malpighian Tubules    41.6 Larval Fat Body  (3535.3) Larval Salivary Gland    66.8 Larval Trachea    314.275 Larval Carcass    171.725 Adult Head  (929.2) Adult Eye    397.35 Adult Brain    175.7 Adult Thoracic-Abdominal Ganglion    189.1 Adult Crop    78.2 Adult Midgut    23.5 Adult Hindgut    235.3 Adult Malpighian Tubules    28 Adult Fat Body  (1150.9) Adult Salivary Gland    438.2 Adult Heart  (583.45) Adult VirginFemale Spermatheca  (2285) Adult InseminatedFemale Spermatheca  (1682.3) Adult Ovary    9.5 Adult Testis    60.7 Adult Male Accessory Gland    12.4 Adult Carcass  (710.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    129.775 Larval Midgut    107.8 Larval Hindgut    539.8 Larval Malpighian Tubules    41.6 Larval Fat Body  (3535.3) Larval Salivary Gland    66.8 Larval Trachea    314.275 Larval Carcass    171.725 Adult Head    929.2 Adult Eye    397.35 Adult Brain    175.7 Adult Thoracic-Abdominal Ganglion    189.1 Adult Crop    78.2 Adult Midgut    23.5 Adult Hindgut    235.3 Adult Malpighian Tubules    28 Adult Fat Body  (1150.9) Adult Salivary Gland    438.2 Adult Heart    583.45 Adult VirginFemale Spermatheca  (2285) Adult InseminatedFemale Spermatheca  (1682.3) Adult Ovary    9.5 Adult Testis    60.7 Adult Male Accessory Gland    12.4 Adult Carcass    710.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    129.775 Larval Midgut    107.8 Larval Hindgut    539.8 Larval Malpighian Tubules    41.6 Larval Fat Body    3535.3 Larval Salivary Gland    66.8 Larval Trachea    314.275 Larval Carcass    171.725 Adult Head    929.2 Adult Eye    397.35 Adult Brain    175.7 Adult Thoracic-Abdominal Ganglion    189.1 Adult Crop    78.2 Adult Midgut    23.5 Adult Hindgut    235.3 Adult Malpighian Tubules    28 Adult Fat Body    1150.9 Adult Salivary Gland    438.2 Adult Heart    583.45 Adult VirginFemale Spermatheca    2285 Adult InseminatedFemale Spermatheca    1682.3 Adult Ovary    9.5 Adult Testis    60.7 Adult Male Accessory Gland    12.4 Adult Carcass    710.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    129.775 Larval Midgut    107.8 Larval Hindgut    539.8 Larval Malpighian Tubules    41.6 Larval Fat Body    3535.3 Larval Salivary Gland    66.8 Larval Trachea    314.275 Larval Carcass    171.725 Adult Head    929.2 Adult Eye    397.35 Adult Brain    175.7 Adult Thoracic-Abdominal Ganglion    189.1 Adult Crop    78.2 Adult Midgut    23.5 Adult Hindgut    235.3 Adult Malpighian Tubules    28 Adult Fat Body    1150.9 Adult Salivary Gland    438.2 Adult Heart    583.45 Adult VirginFemale Spermatheca    2285 Adult InseminatedFemale Spermatheca    1682.3 Adult Ovary    9.5 Adult Testis    60.7 Adult Male Accessory Gland    12.4 Adult Carcass    710.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    129.775 Larval Midgut    107.8 Larval Hindgut  539.8 Larval Malpighian Tubules    41.6 Larval Fat Body  (3535.3) Larval Salivary Gland    66.8 Larval Trachea    314.275 Larval Carcass    171.725 Adult Head  (929.2) Adult Eye    397.35 Adult Brain    175.7 Adult Thoracic-Abdominal Ganglion    189.1 Adult Crop    78.2 Adult Midgut    23.5 Adult Hindgut    235.3 Adult Malpighian Tubules    28 Adult Fat Body  (1150.9) Adult Salivary Gland    438.2 Adult Heart  583.45 Adult VirginFemale Spermatheca  (2285) Adult InseminatedFemale Spermatheca  (1682.3) Adult Ovary    9.5 Adult Testis    60.7 Adult Male Accessory Gland    12.4 Adult Carcass  710.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    129.775 Larval Midgut    107.8 Larval Hindgut    539.8 Larval Malpighian Tubules    41.6 Larval Fat Body  (3535.3) Larval Salivary Gland    66.8 Larval Trachea    314.275 Larval Carcass    171.725 Adult Head    929.2 Adult Eye    397.35 Adult Brain    175.7 Adult Thoracic-Abdominal Ganglion    189.1 Adult Crop    78.2 Adult Midgut    23.5 Adult Hindgut    235.3 Adult Malpighian Tubules    28 Adult Fat Body  1150.9 Adult Salivary Gland    438.2 Adult Heart    583.45 Adult VirginFemale Spermatheca  (2285) Adult InseminatedFemale Spermatheca  1682.3 Adult Ovary    9.5 Adult Testis    60.7 Adult Male Accessory Gland    12.4 Adult Carcass    710.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    129.775 Larval Midgut    107.8 Larval Hindgut    539.8 Larval Malpighian Tubules    41.6 Larval Fat Body    3535.3 Larval Salivary Gland    66.8 Larval Trachea    314.275 Larval Carcass    171.725 Adult Head    929.2 Adult Eye    397.35 Adult Brain    175.7 Adult Thoracic-Abdominal Ganglion    189.1 Adult Crop    78.2 Adult Midgut    23.5 Adult Hindgut    235.3 Adult Malpighian Tubules    28 Adult Fat Body    1150.9 Adult Salivary Gland    438.2 Adult Heart    583.45 Adult VirginFemale Spermatheca    2285 Adult InseminatedFemale Spermatheca    1682.3 Adult Ovary    9.5 Adult Testis    60.7 Adult Male Accessory Gland    12.4 Adult Carcass    710.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    929.2   NA  Eye    397.35   NA  Brain    175.7   129.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    189.1   NA  Crop    78.2   107.8  Midgut    no informative data   539.8  Hindgut    235.3   41.6  Malpighian Tubules    no informative data   3535.3  Fat Body    1150.9   66.8  Salivary Gland    438.2   NA  Heart    583.45   314.275  Trachea    NA   NA  VirginFemale Spermatheca    2285   NA  InseminatedFemale Spermatheca    1682.3   NA  Ovary    9.5   NA  Testis    60.7   NA  Male Accessory Gland    no informative data   171.725  Carcass    710.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    39 head, virgin 4-day female    30 head, virgin 20-day female    102 head, mated 1-day female    24 head, mated 4-day female    32 head, mated 20-day female    69 head, mated 1-day male    29 head, mated 4-day male    39 head, mated 20-day male    79 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    935 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    5 digestive system, 4-day adult    3 digestive system, 20-day adult    6 fat body, larvae L3 wandering    100 fat body, white prepupae    176 fat body, pupae P8    55 carcass, larvae L3 wandering    14 carcass, 1-day adult    68 carcass, 4-day adult    29 carcass, 20-day adult    90 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female  (39) head, virgin 4-day female  (30) head, virgin 20-day female  (102) head, mated 1-day female    24 head, mated 4-day female  (32) head, mated 20-day female  (69) head, mated 1-day male  (29) head, mated 4-day male  (39) head, mated 20-day male  (79) salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (935) digestive system, larvae L3 wandering    24 digestive system, 1-day adult    5 digestive system, 4-day adult    3 digestive system, 20-day adult    6 fat body, larvae L3 wandering  (100) fat body, white prepupae  (176) fat body, pupae P8  (55) carcass, larvae L3 wandering    14 carcass, 1-day adult  (68) carcass, 4-day adult  (29) carcass, 20-day adult  (90) ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    39 head, virgin 4-day female    30 head, virgin 20-day female  102 head, mated 1-day female    24 head, mated 4-day female    32 head, mated 20-day female    69 head, mated 1-day male    29 head, mated 4-day male    39 head, mated 20-day male    79 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (935) digestive system, larvae L3 wandering    24 digestive system, 1-day adult    5 digestive system, 4-day adult    3 digestive system, 20-day adult    6 fat body, larvae L3 wandering    100 fat body, white prepupae  (176) fat body, pupae P8    55 carcass, larvae L3 wandering    14 carcass, 1-day adult    68 carcass, 4-day adult    29 carcass, 20-day adult    90 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    39 head, virgin 4-day female    30 head, virgin 20-day female    102 head, mated 1-day female    24 head, mated 4-day female    32 head, mated 20-day female    69 head, mated 1-day male    29 head, mated 4-day male    39 head, mated 20-day male    79 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    935 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    5 digestive system, 4-day adult    3 digestive system, 20-day adult    6 fat body, larvae L3 wandering    100 fat body, white prepupae    176 fat body, pupae P8    55 carcass, larvae L3 wandering    14 carcass, 1-day adult    68 carcass, 4-day adult    29 carcass, 20-day adult    90 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    39 head, virgin 4-day female    30 head, virgin 20-day female    102 head, mated 1-day female    24 head, mated 4-day female    32 head, mated 20-day female    69 head, mated 1-day male    29 head, mated 4-day male    39 head, mated 20-day male    79 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    935 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    5 digestive system, 4-day adult    3 digestive system, 20-day adult    6 fat body, larvae L3 wandering    100 fat body, white prepupae    176 fat body, pupae P8    55 carcass, larvae L3 wandering    14 carcass, 1-day adult    68 carcass, 4-day adult    29 carcass, 20-day adult    90 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female  (39) head, virgin 4-day female  30 head, virgin 20-day female  (102) head, mated 1-day female    24 head, mated 4-day female  32 head, mated 20-day female  (69) head, mated 1-day male  29 head, mated 4-day male  (39) head, mated 20-day male  (79) salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (935) digestive system, larvae L3 wandering    24 digestive system, 1-day adult    5 digestive system, 4-day adult    3 digestive system, 20-day adult    6 fat body, larvae L3 wandering  (100) fat body, white prepupae  (176) fat body, pupae P8  (55) carcass, larvae L3 wandering    14 carcass, 1-day adult  (68) carcass, 4-day adult  29 carcass, 20-day adult  (90) ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    39 head, virgin 4-day female    30 head, virgin 20-day female  102 head, mated 1-day female    24 head, mated 4-day female    32 head, mated 20-day female    69 head, mated 1-day male    29 head, mated 4-day male    39 head, mated 20-day male    79 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (935) digestive system, larvae L3 wandering    24 digestive system, 1-day adult    5 digestive system, 4-day adult    3 digestive system, 20-day adult    6 fat body, larvae L3 wandering    100 fat body, white prepupae  (176) fat body, pupae P8    55 carcass, larvae L3 wandering    14 carcass, 1-day adult    68 carcass, 4-day adult    29 carcass, 20-day adult    90 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    39 head, virgin 4-day female    30 head, virgin 20-day female    102 head, mated 1-day female    24 head, mated 4-day female    32 head, mated 20-day female    69 head, mated 1-day male    29 head, mated 4-day male    39 head, mated 20-day male    79 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    935 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    5 digestive system, 4-day adult    3 digestive system, 20-day adult    6 fat body, larvae L3 wandering    100 fat body, white prepupae    176 fat body, pupae P8    55 carcass, larvae L3 wandering    14 carcass, 1-day adult    68 carcass, 4-day adult    29 carcass, 20-day adult    90 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    11 embryo 08-10hr    17 embryo 10-12hr    22 embryo 12-14hr    40 embryo 14-16hr    31 embryo 16-18hr    20 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    9 larva L2    20 larva L3 12hr old    39 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    72 larva L3 puffstage 7-9    59 white prepupae new    115 white prepupae 12hr    108 white prepupae 24hr    80 pupae 2d postWPP    74 pupae 3d postWPP    39 pupae 4d postWPP    10 adult male 01day    25 adult male 05day    18 adult male 30day    19 adult female 01day    14 adult female 05day    13 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    11 embryo 08-10hr    17 embryo 10-12hr    22 embryo 12-14hr  (40) embryo 14-16hr  (31) embryo 16-18hr    20 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    9 larva L2    20 larva L3 12hr old  (39) larva L3 puffstage 1-2  (65) larva L3 puffstage 3-6  (72) larva L3 puffstage 7-9  (59) white prepupae new  (115) white prepupae 12hr  (108) white prepupae 24hr  (80) pupae 2d postWPP  (74) pupae 3d postWPP  (39) pupae 4d postWPP    10 adult male 01day    25 adult male 05day    18 adult male 30day    19 adult female 01day    14 adult female 05day    13 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    11 embryo 08-10hr    17 embryo 10-12hr    22 embryo 12-14hr    40 embryo 14-16hr    31 embryo 16-18hr    20 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    9 larva L2    20 larva L3 12hr old    39 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    72 larva L3 puffstage 7-9    59 white prepupae new  (115) white prepupae 12hr  (108) white prepupae 24hr    80 pupae 2d postWPP    74 pupae 3d postWPP    39 pupae 4d postWPP    10 adult male 01day    25 adult male 05day    18 adult male 30day    19 adult female 01day    14 adult female 05day    13 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    11 embryo 08-10hr    17 embryo 10-12hr    22 embryo 12-14hr    40 embryo 14-16hr    31 embryo 16-18hr    20 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    9 larva L2    20 larva L3 12hr old    39 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    72 larva L3 puffstage 7-9    59 white prepupae new    115 white prepupae 12hr    108 white prepupae 24hr    80 pupae 2d postWPP    74 pupae 3d postWPP    39 pupae 4d postWPP    10 adult male 01day    25 adult male 05day    18 adult male 30day    19 adult female 01day    14 adult female 05day    13 adult female 30day    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    11 embryo 08-10hr    17 embryo 10-12hr    22 embryo 12-14hr    40 embryo 14-16hr    31 embryo 16-18hr    20 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    9 larva L2    20 larva L3 12hr old    39 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    72 larva L3 puffstage 7-9    59 white prepupae new    115 white prepupae 12hr    108 white prepupae 24hr    80 pupae 2d postWPP    74 pupae 3d postWPP    39 pupae 4d postWPP    10 adult male 01day    25 adult male 05day    18 adult male 30day    19 adult female 01day    14 adult female 05day    13 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    11 embryo 08-10hr    17 embryo 10-12hr    22 embryo 12-14hr  (40) embryo 14-16hr  31 embryo 16-18hr    20 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    9 larva L2    20 larva L3 12hr old  (39) larva L3 puffstage 1-2  (65) larva L3 puffstage 3-6  (72) larva L3 puffstage 7-9  (59) white prepupae new  (115) white prepupae 12hr  (108) white prepupae 24hr  (80) pupae 2d postWPP  (74) pupae 3d postWPP  (39) pupae 4d postWPP    10 adult male 01day    25 adult male 05day    18 adult male 30day    19 adult female 01day    14 adult female 05day    13 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    11 embryo 08-10hr    17 embryo 10-12hr    22 embryo 12-14hr    40 embryo 14-16hr    31 embryo 16-18hr    20 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    9 larva L2    20 larva L3 12hr old    39 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    72 larva L3 puffstage 7-9    59 white prepupae new  115 white prepupae 12hr  108 white prepupae 24hr    80 pupae 2d postWPP    74 pupae 3d postWPP    39 pupae 4d postWPP    10 adult male 01day    25 adult male 05day    18 adult male 30day    19 adult female 01day    14 adult female 05day    13 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    11 embryo 08-10hr    17 embryo 10-12hr    22 embryo 12-14hr    40 embryo 14-16hr    31 embryo 16-18hr    20 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    9 larva L2    20 larva L3 12hr old    39 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    72 larva L3 puffstage 7-9    59 white prepupae new    115 white prepupae 12hr    108 white prepupae 24hr    80 pupae 2d postWPP    74 pupae 3d postWPP    39 pupae 4d postWPP    10 adult male 01day    25 adult male 05day    18 adult male 30day    19 adult female 01day    14 adult female 05day    13 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    9 embryonic 1182-4H    4 embryonic GM2    84 embryonic Kc167    5 embryonic S1    42 embryonic S3    1 leg disc CME L1    15 wing disc CME-W2    12 wing disc ML-DmD8    4 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    69 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    9 embryonic 1182-4H    4 embryonic GM2  (84) embryonic Kc167    5 embryonic S1  (42) embryonic S3    1 leg disc CME L1    15 wing disc CME-W2    12 wing disc ML-DmD8    4 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32  (29) haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2  (66) tumorous blood cells mbn2  (69) ovary fGS/OSS    0 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    9 embryonic 1182-4H    4 embryonic GM2    84 embryonic Kc167    5 embryonic S1    42 embryonic S3    1 leg disc CME L1    15 wing disc CME-W2    12 wing disc ML-DmD8    4 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    69 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    9 embryonic 1182-4H    4 embryonic GM2    84 embryonic Kc167    5 embryonic S1    42 embryonic S3    1 leg disc CME L1    15 wing disc CME-W2    12 wing disc ML-DmD8    4 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    69 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    9 embryonic 1182-4H    4 embryonic GM2    84 embryonic Kc167    5 embryonic S1    42 embryonic S3    1 leg disc CME L1    15 wing disc CME-W2    12 wing disc ML-DmD8    4 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    69 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    9 embryonic 1182-4H    4 embryonic GM2  (84) embryonic Kc167    5 embryonic S1  (42) embryonic S3    1 leg disc CME L1    15 wing disc CME-W2    12 wing disc ML-DmD8    4 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32  29 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2  (66) tumorous blood cells mbn2  (69) ovary fGS/OSS    0 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    9 embryonic 1182-4H    4 embryonic GM2    84 embryonic Kc167    5 embryonic S1    42 embryonic S3    1 leg disc CME L1    15 wing disc CME-W2    12 wing disc ML-DmD8    4 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    69 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    9 embryonic 1182-4H    4 embryonic GM2    84 embryonic Kc167    5 embryonic S1    42 embryonic S3    1 leg disc CME L1    15 wing disc CME-W2    12 wing disc ML-DmD8    4 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    69 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    38 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    47 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  (38) heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3  (34) Cadmium 50 mM 48 hrs, 4-day adult  26 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3  (31) Ethanol 10% 3 hrs, larvae L3  (33) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (47) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    38 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    47 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    38 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    47 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    38 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    47 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  (38) heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3  (34) Cadmium 50 mM 48 hrs, 4-day adult  26 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3  31 Ethanol 10% 3 hrs, larvae L3  (33) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (47) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    38 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    47 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    38 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    47 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	BDGP expression data • GH01829 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041182 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7052-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Tep2 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Tep2GD12828 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Tep2 Class Mutagen Stocks Known lesion Tep2f02756 piggyBac transposase 1 -- Tep2MI00116 1 -- Tep2MI00250 1 -- Tep2MI01299 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tep2 Class Mutagen Stocks Known lesion Tep2GD12828 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tep2KK101058 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tep2NIG.18589R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6018 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.18589R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Tep2MI00116 NA Mi{MIC}Tep2MI00250 NA Mi{MIC}Tep2MI01299 NA P{SUPor-P}KG04622 NA PBac{WH}Tep2f02756 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from direct assay (Lagueux et al., 2000) defense response to Gram-negative bacterium inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
endopeptidase inhibitor activity inferred from electronic annotation with InterPro:IPR001599, InterPro:IPR002890 (FlyBase Curators et al., 2004-) peptidase inhibitor activity inferred from sequence or structural similarity with UniProtKB:P20740 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular space inferred from electronic annotation with InterPro:IPR011626 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Tep2 - CG11911 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tep2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60184 DroID - A comprehensive database of gene and protein interactions. • FBgn0041182 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34044
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XH0JD Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6N038Z Arthropod inclusive ortholog search EOG6X0K76 Metazoa inclusive ortholog search EOG6FNH9H
Orthologs in Drosophila Species (EOG6XH0JD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tep2     Drosophila simulans   Dsim\Tep2 Y   Drosophila sechellia   Dsec\Tep2 Y   Drosophila erecta   Dere\Tep2 Y   Drosophila yakuba   Dyak\Tep2 Y   Drosophila ananassae   Dana\Tep2 Y   Drosophila pseudoobscura pseudoobscura   Dpse\Tep2 Y   Drosophila persimilis   Dper\Tep2     Drosophila willistoni   Dwil\Tep2 Y   Drosophila virilis   Dvir\Tep2 Y   Drosophila mojavensis   Dmoj\Tep2     Drosophila grimshawi   Dgri\Tep2     Drosophila grimshawi   Dgri\GH10069
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6N038Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\TEP7 Y Apis mellifera Western honey bee  Amel\GB45417 Y Apis mellifera Western honey bee  Amel\GB42916 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014366 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002345 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18159 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27221 Y Atta cephalotes Leafcutter ant  Acep\ACEP15943 Y Atta cephalotes Leafcutter ant  Acep\ACEP26930 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21867 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16229 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21520 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21153 Y Linepithema humile Argentine ant  Lhum\LH26214 Y Linepithema humile Argentine ant  Lhum\LH26167 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB10964 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23550 Y Solenopsis invicta Red fire ant  Sinv\SINV24569 Y Solenopsis invicta Red fire ant  Sinv\SINV24588 Y Solenopsis invicta Red fire ant  Sinv\SINV11052 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005292 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012631 Y Pediculus humanus Human body louse  Phum\PHUM375050 Y Pediculus humanus Human body louse  Phum\PHUM289710 Y Tribolium castaneum Red flour beetle  Tcas\TC014664 Y Tribolium castaneum Red flour beetle  Tcas\TC009667 Y
Orthologs in non-Insect Arthropods (EOG6X0K76)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI Y Ixodes scapularis Deer tick  Isca\ISCW020822 Y
Orthologs in non-Arthropod Metazoa (EOG6FNH9H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019294gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024565gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024564gn Y Danio rerio Zebrafish  Drer\ENSDARG00000060609 Y Danio rerio Zebrafish  Drer\sb:cb37 Y Xenopus tropicalis Western clawed frog  Xtro\pzp Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031004 Y Gallus gallus Domestic chicken  Ggal\CD109 Y Mus musculus House mouse  Mmus\Cd109 Y Rattus norvegicus Norway rat  Rnor\LOC297568 Y Rattus norvegicus Norway rat  Rnor\Mug2 Y Rattus norvegicus Norway rat  Rnor\Cd109 Y Homo sapiens Human  Hsap\CD109 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\CD109
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Tep2 Drosophila sechellia Dsec\Tep2 Drosophila erecta Dere\Tep2 Drosophila yakuba Dyak\Tep2 Drosophila ananassae Dana\Tep2 Drosophila pseudoobscura pseudoobscura Dpse\Tep2 Drosophila willistoni Dwil\Tep2 Drosophila virilis Dvir\Tep2 Drosophila mojavensis Dmoj\Tep3
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	30624 y1 w*; Mi{MIC}Tep2MI00116 30950 y1 w*; Mi{MIC}Tep2MI00250 44129 y1 w*; Mi{MIC}Tep2MI01299
Harvard	- PBac{WH}Tep2f02756
VDRC	v106997 P{KK101058}VIE-260B v35611 w1118; P{GD12828}v35611/CyO
Genomic Clones ( 2 )
	BACR09A04 BACR16J09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 98 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01829 GH08432
Other clones	yak-em_tep2
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL03991 HL04948 HL07316 LP02258 SD01123 SD05542
Other clones	9721 12630 12717 54804 56923 62049 72811 82469 119103 286684 294338 297330 CK01.36B.D8 CK01.37C.B6 CK01.64A.E11 CK01.85B.G6 CK01.108D.E2 EC30670 EC37441 EC41008 EC253315 EC253789 EK032159 EK052020 EK064619 EK067559 EK098149 EK109322 EK113449 EK114062 EK169724 EK179958 EK189115 EK201650 EK215861 EN07640 EN12020 EN14115 EP05806 EP09935 ESG011c.E21_B09 ESG012b.E21_E02 ESG012b.TE.3_H06 ESG013b.E21_B04 ESG013b.E21_D05 ESG013c.E21_F07 ESG015a.E21_F10 ESG017a.E21_C03 ESG017a.E21_E10 ESG017d.E21_E06 ESG018a.E21_H08 ESG019d.E21_D12 ESG0110b.E21_H02 ESG0111b.B21.1_G12 ESG0111c.B21.1_G05 ESG0113a.B21_D12 ESG0114a.B21_G05 ESG0114b.B21_H03 ESG0115a.B21_B06 ESG0116a.B21_F06 ESG0120b.B21_C04 IP16154 IP16254 IP16354 RP004047643 RP004061343 RP004095719 RP004105183 RP004108589 RP004108608 RP004117879 RP004156705 RP004162103 RP004240721 RP004241359 RP004258264 RP004259373 RP004259703 RP004263288 RP004286371 RP004319538 RP004340949 RP004349621 RP004372843 RP004405880 RP004445396 RP004459915 RP004485982 RP004534998
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041182 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34044
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tep2 TepII (Bou Aoun et al., 2011)
Source for database merge of	Source for merge of: TepII CG7052 (FlyBase, 1996-) Source for merge of: TepII CG18589 (FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG7052 and CG18589 merged as CG7052 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of TepII CG7052 was sequence comparison (date:000423). (FlyBase, 1996-)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Escherichia coli compared to untreated cells. However, the dsRNA treatment does not affect phagocytosis of Candida albicans or Staphylococcus aureus. (Stroschein-Stevenson et al., 2006) Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background. (McDonald and Rosbash, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078782 NM_164761 NM_164762 NM_164763 NM_164764 RefSeq (Proteins) • NP_523506 NP_723298 NP_723299 NP_723300 NP_723301 DDBJ / EMBL / GenBank • AAF52539 AAF52540 AAF52541 AAM48331 AAM52596 AAN10639 AAN10640 AI062586 AI109290 AJ269539 AY118302 AY122084 CAB87808 CZ485304 CZ485305 Entrez Gene - A searchable database of RefSeq genes. • 34044 UniProtKB/TrEMBL • Q8IPH4 Q8IPH5 Q8MT94 Q9NFV7 Q9VLY9 Q9VLZ0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Alpha-2-macroglobulin, N-terminal (IPR002890) Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (IPR008930) Alpha-macroglobulin, receptor-binding (IPR009048) Alpha-2-macroglobulin, N-terminal 2 (IPR011625) A-macroglobulin complement component (IPR011626) Alpha-2-macroglobulin, conserved site (IPR019742) Alpha-2-macroglobulin, thiol-ester bond-forming (IPR019565) Alpha-2-macroglobulin (IPR001599) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH01829
Linkouts
	BioGRID - A database of protein and genetic interactions • 60184 DroID - A comprehensive database of gene and protein interactions. • FBgn0041182 DRSC - Results from RNAi screens. • FBgn0041182 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041182 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7052-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041182 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34044 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34044 modMine - Data generated by the modENCODE project. • FBgn0041182
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	145970_at (Kristensen et al., 2005) 145971_at (Kristensen et al., 2005) CG7052 (Nakahara et al., 2005, Vierstraete et al., 2004, Asha et al., 2003, Irving et al., 2001, De Gregorio et al., 2001, Bou Aoun et al., 2011, Stroschein-Stevenson et al., 2006, Bou Aoun et al., 2011, Keleman et al., 2009.8.5, Heger and Ponting, 2007, Wertheim et al., 2005) CG18589 (Boutros et al., 2002, McDonald and Rosbash, 2001, ) dTEPII (Irving et al., 2001, Lagueux, 2000.3.15, Lagueux et al., 2000) T13 (Vierstraete et al., 2004) Tep2 (Waterhouse et al., 2007, Asha et al., 2003, De Gregorio et al., 2002, De Gregorio et al., 2001, Lagueux et al., 2000, Lagueux, 2000.4.11, Bou Aoun et al., 2008, Bou Aoun et al., 2011) TEP2 (Vierstraete et al., 2004, Bou Aoun et al., 2011) Tep 2 (An et al., 2012) TEP2mel (Bou Aoun et al., 2011) TepII (Sackton and Clark, 2009, Shin et al., 2005, Stroschein-Stevenson et al., 2006, Brun et al., 2006, Christophides et al., 2002, Ye and McGraw, 2011, Kwon et al., 2008, Gilchrist et al., 2008, Buchon et al., 2009, Sackton et al., 2007, Obbard et al., 2009, Heger and Ponting, 2007, Wertheim et al., 2005, Curtis et al., 2007, Wasbrough et al., 2010, Jiggins and Kim, 2006, Marcu et al., 2011, Japanese National Institute of Genetics, 2012.5.21) TEP II (Mudiganti et al., 2010) Tep II (Ye et al., 2009) tepII (Igboin et al., 2011)
Name Synonym	TEP (Erturk-Hasdemir and Silverman, 2005) Thioester-containing protein 2   Thioester containing protein II (Marcu et al., 2011) Thiolester containing protein II (Lagueux et al., 2000, Ye et al., 2009)
Secondary FlyBase IDs
	FBgn0031931 FBgn0031932
References ( 65 )
Generate a list of	All references relating to this gene ( 65 )
List References by type	Research paper  ( 37 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 8 )
	An et al., 2012, PLoS ONE 7(3): e34510 Insect Neuropeptide Bursicon Homodimers Induce Innate Immune and Stress Genes during Molting by Activating the NF-κB Transcription Factor Relish. [FBrf0217909] Gilchrist et al., 2012, Genes Dev. 26(9): 933--944 Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks. [FBrf0218258] Xu et al., 2012, Cell Host Microbe 12(4): 531--543 Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila. [FBrf0219695] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Bou Aoun et al., 2011, J. Innate Immun. 3(1): 52--64 Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster. [FBrf0212631] Igboin et al., 2011, Infect. Immun. 79(1): 449--458 Porphyromonas gingivalis-Host Interactions in a Drosophila melanogaster Model. [FBrf0212619] Marcu et al., 2011, PLoS ONE 6(1): e15361 Innate Immune Responses of Drosophila melanogaster Are Altered by Spaceflight. [FBrf0212851] Ye and McGraw, 2011, BMC Res. Notes 4: 305 Adult Drosophila melanogaster evolved for antibacterial defense invest in infection-induced expression of both humoral and cellular immunity genes. [FBrf0215821] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...