Suppressor of cytokine signaling 36E, Socs
inhibitor of JAK/STAT pathway, works vie a protein degradation pathway, cooperates with EGFR to regulate oncogenic transformation, optimizes motile cell specification in the ovary, regulator of niche competition in the testis, regulated by Histone demethylase
Please see the JBrowse view of Dmel\Socs36E for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.44
Stop-codon suppression (UAG) postulated; FBrf0216884.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
The group(s) of polypeptides indicated below share identical sequence to each other.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Socs36E using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: complementary pattern to twi
Comment: reported as posterior spiracle specific anlage
Comment: expressed where the proventriculus joins the anterior midgut
Comment: expressed where the posterior midgut joins the hindgut
Comment: paper states 2-24 hr AEL; expression weak after 12 hr AEL
Expression of Socs36E in wild-type embryos is higher on the inside of the hindgut curve.
The 2.5 kb Socs36E transcript is observed in S2 cultured cells but not in vivo. Strong transcript expression is observed from embryonic stage 5 through stage 15 (2-13 hrs AEL). Weak expression is observed from late stage 15 through stage 17, and faint expression is observed in third instar larvae and in pupae. Early embryonic expression is observed in dorsal/ventral stripes. By stage 9, these stripes are mesodermal and segmentally repeated.
Socs36E protein is highly expressed in cyst cells in the testis.
Comment: anterior and posterior follicle cells
Comment: anterior and posterior follicle cells
JBrowse - Visual display of RNA-Seq signals
View Dmel\Socs36E in JBrowse2-53
2-53.2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Somatic Socs36E non-autonomously regulates the self-renewal of germline stem cells in the testis.
Socs36E suppresses JAK/STAT signalling in somatic cyst progenitor cells in the testis, preventing them from out-competing the germline stem cells.
dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway.
Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against Socs36E results in a 3-fold increase in JAK/STAT activity.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Source for merge of: Socs36E anon- EST:Liang-2.2
Source for merge of: Socs36E CG15154
Source for identity of: Socs36E Socs
