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Gene Dmel\Socs36E

General Information
Symbol	Dmel\Socs36E	Species	D. melanogaster
Name	Suppressor of cytokine signaling at 36E	Annotation symbol	CG15154
Feature type	protein_coding_gene	FlyBase ID	FBgn0041184
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	SOCS
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36E6-36E6	Sequence location	2L:18,138,675..18,152,417 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Suppressor of cytokine signaling at 36E is referred to in FlyBase by the symbol Dmel\Socs36E (CG15154, FBgn0041184). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: notum morphogenesis; germ-line stem cell maintenance; negative regulation of sevenless signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of epidermal growth factor receptor signaling pathway; haltere development; compound eye pigmentation; imaginal disc-derived wing vein morphogenesis; negative regulation of R7 cell differentiation; long-term memory. 22 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; eye; male germline stem cell; anterior crossvein; haltere; border follicle cell; wing; humerus; wing vein; pigment cell. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: SH2 domain; SOCS protein, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637703_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Socs36E. Gene sequence location is 2L:18138675..18152410.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36E6-36E6   Limits computationally determined from genome sequence between P{lacW}Aac11k06710 and P{EP}CG10413EP2164
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Socs36E for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.51 gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UAG) postulated; FBrf0216884. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Socs36E-RA FBtr0081040  NM_165243   3503   633 Socs36E-RC FBtr0329927  NM_001273605   3334   633 Socs36E-RD FBtr0329928  NM_078869   3503   737 Socs36E-RE FBtr0329929  NM_001273606   3725   296
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Socs36E-PA   FBpp0080593   68.9   633   7.39     NP_724096   AAF53652 Socs36E-PC   FBpp0302959   68.9   633   7.39     NP_001260534   AGB93069 Socs36E-PD   FBpp0302960   80.3   737   6.85     NP_523593   AAN11183 Socs36E-PE   FBpp0302961   32.1   296   4.70     NP_001260535   AGB93070
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SH2 domain (IPR000980) SOCS protein, C-terminal (IPR001496)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA940627   AA950055   AE014134 AAF53652   AE014134 AAN11183   AC006471   AF435838 AAL30823   AF435839 AAL30824   AE014134 AGB93069   AE014134 AGB93070   AI124294   AI532714   AI532723   AI534458   AI542735   AI543446   AW944356   BI170922   BI172829   BI213670   BI228157   BI373842   BI485679   BI565807   BI581611   BI605303   BI626651   BI626672   BI636446   BP542298   BP549741   BP549742   BP556101   BP556102   BQ103181   BT003433 AAO39436   CK657524   CL527927   CO179729   CO190551   CO196302   CO262879   CO267202   CO270778   CO276945   CO279008   CO290685   CO290774   CO293389   CO311760   CO325128   CO325202   CO329690   CO342484   CO342574   EC058935   EC067356   EC074894   EC074895   EC075112   EC080925   EC195977   EC207863   EC208103   EC208762   EC210125   EC211392   EC225355   EC243608   EC245501   EC248246   EC260508   GH954770   GH967029   GH967613   GH971720
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VJA1 Q86P82 Q8WTC2 Q8INY1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435052 2L:18,142,770..18,145,071 evidence=Reporter construct (in vivo) (Liu et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000435768 2L:18,149,771..18,152,121 evidence=Reporter construct (in vivo) (Liu et al., 2009, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 4 -- 11   organism | striped   (Rawlings et al., 2004) embryonic stage 6   organism | striped   (Callus and Mathey-Prevot, 2002) Comment:dorsal/ventral stripes embryonic stage 7 -- 8   trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 12   mesoderm | segmentally repeated & striped   (Callus and Mathey-Prevot, 2002) embryonic stage 11 -- 12   clypeo-labral primordium   (Fisher et al., 2012) posterior spiracle primordium   (Fisher et al., 2012) Comment:reported as posterior spiracle specific anlage embryonic stage 12 -- 13   tracheal pit   (Rawlings et al., 2004) embryonic stage 13 -- 16   embryonic epipharynx   (Fisher et al., 2012) embryonic stage 14 -- 17   embryonic/larval trachea   (Rawlings et al., 2004) embryonic stage 16 -- 17   embryonic/larval proventriculus | restricted & anterior embryonic/larval midgut | restricted   (Callus and Mathey-Prevot, 2002) Comment:expressed where the proventriculus joins the anterior midgut posterior embryonic/larval midgut | restricted & embryonic/larval hindgut | restricted   (Callus and Mathey-Prevot, 2002) Comment:expressed where the posterior midgut joins the hindgut oogenesis   polar follicle cell   (Rawlings et al., 2004) polar follicle cell | vicinity of   (Rawlings et al., 2004) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 17   organism   (Callus and Mathey-Prevot, 2002) Comment:paper states 2-24 hr AEL; expression weak after 12 hr AEL third instar larval stage -- pupal stage   organism | faint   (Callus and Mathey-Prevot, 2002)   S2 cell-line   (Callus and Mathey-Prevot, 2002)
Additional Descriptive Data
	Socs36E transcript is expressed in a striped pattern similar to that of os through germ band extension. During oogenesis, Socs36E transcript is expressed in the polar follicle cells, and in the follicle cells near the polar follicle cells. (Rawlings et al., 2004) The 2.5 kb Socs36E transcript is observed in S2 cultured cells but not in vivo. Strong transcript expression is observed from embryonic stage 5 through stage 15 (2-13 hrs AEL). Weak expression is observed from late stage 15 through stage 17, and faint expression is observed in third instar larvae and in pupae. Early embryonic expression is observed in dorsal/ventral stripes. By stage 9, these stripes are mesodermal and segmentally repeated. (Callus and Mathey-Prevot, 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    469.8 Larval Midgut    891 Larval Hindgut    665 Larval Malpighian Tubules    469.3 Larval Fat Body    70.8 Larval Salivary Gland    183.1 Larval Trachea    336.85 Larval Carcass    385.7 Adult Head    141.8 Adult Eye    218.975 Adult Brain    356.7 Adult Thoracic-Abdominal Ganglion    292.5 Adult Crop    210.3 Adult Midgut    664.2 Adult Hindgut    229.7 Adult Malpighian Tubules    304.6 Adult Fat Body    59.8 Adult Salivary Gland    171.9 Adult Heart    75.95 Adult VirginFemale Spermatheca    118.2 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    41.5 Adult Testis    73.1 Adult Male Accessory Gland    123 Adult Carcass    82.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    469.8 Larval Midgut  (891) Larval Hindgut  (665) Larval Malpighian Tubules    469.3 Larval Fat Body    70.8 Larval Salivary Gland    183.1 Larval Trachea    336.85 Larval Carcass    385.7 Adult Head    141.8 Adult Eye    218.975 Adult Brain    356.7 Adult Thoracic-Abdominal Ganglion    292.5 Adult Crop    210.3 Adult Midgut  (664.2) Adult Hindgut    229.7 Adult Malpighian Tubules    304.6 Adult Fat Body    59.8 Adult Salivary Gland    171.9 Adult Heart    75.95 Adult VirginFemale Spermatheca    118.2 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    41.5 Adult Testis    73.1 Adult Male Accessory Gland    123 Adult Carcass    82.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    469.8 Larval Midgut    891 Larval Hindgut    665 Larval Malpighian Tubules    469.3 Larval Fat Body    70.8 Larval Salivary Gland    183.1 Larval Trachea    336.85 Larval Carcass    385.7 Adult Head    141.8 Adult Eye    218.975 Adult Brain    356.7 Adult Thoracic-Abdominal Ganglion    292.5 Adult Crop    210.3 Adult Midgut    664.2 Adult Hindgut    229.7 Adult Malpighian Tubules    304.6 Adult Fat Body    59.8 Adult Salivary Gland    171.9 Adult Heart    75.95 Adult VirginFemale Spermatheca    118.2 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    41.5 Adult Testis    73.1 Adult Male Accessory Gland    123 Adult Carcass    82.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    469.8 Larval Midgut    891 Larval Hindgut    665 Larval Malpighian Tubules    469.3 Larval Fat Body    70.8 Larval Salivary Gland    183.1 Larval Trachea    336.85 Larval Carcass    385.7 Adult Head    141.8 Adult Eye    218.975 Adult Brain    356.7 Adult Thoracic-Abdominal Ganglion    292.5 Adult Crop    210.3 Adult Midgut    664.2 Adult Hindgut    229.7 Adult Malpighian Tubules    304.6 Adult Fat Body    59.8 Adult Salivary Gland    171.9 Adult Heart    75.95 Adult VirginFemale Spermatheca    118.2 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    41.5 Adult Testis    73.1 Adult Male Accessory Gland    123 Adult Carcass    82.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    469.8 Larval Midgut    891 Larval Hindgut    665 Larval Malpighian Tubules    469.3 Larval Fat Body    70.8 Larval Salivary Gland    183.1 Larval Trachea    336.85 Larval Carcass    385.7 Adult Head    141.8 Adult Eye    218.975 Adult Brain    356.7 Adult Thoracic-Abdominal Ganglion    292.5 Adult Crop    210.3 Adult Midgut    664.2 Adult Hindgut    229.7 Adult Malpighian Tubules    304.6 Adult Fat Body    59.8 Adult Salivary Gland    171.9 Adult Heart    75.95 Adult VirginFemale Spermatheca    118.2 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    41.5 Adult Testis    73.1 Adult Male Accessory Gland    123 Adult Carcass    82.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    469.8 Larval Midgut  (891) Larval Hindgut  665 Larval Malpighian Tubules    469.3 Larval Fat Body    70.8 Larval Salivary Gland    183.1 Larval Trachea    336.85 Larval Carcass    385.7 Adult Head    141.8 Adult Eye    218.975 Adult Brain    356.7 Adult Thoracic-Abdominal Ganglion    292.5 Adult Crop    210.3 Adult Midgut  664.2 Adult Hindgut    229.7 Adult Malpighian Tubules    304.6 Adult Fat Body    59.8 Adult Salivary Gland    171.9 Adult Heart    75.95 Adult VirginFemale Spermatheca    118.2 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    41.5 Adult Testis    73.1 Adult Male Accessory Gland    123 Adult Carcass    82.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    469.8 Larval Midgut    891 Larval Hindgut    665 Larval Malpighian Tubules    469.3 Larval Fat Body    70.8 Larval Salivary Gland    183.1 Larval Trachea    336.85 Larval Carcass    385.7 Adult Head    141.8 Adult Eye    218.975 Adult Brain    356.7 Adult Thoracic-Abdominal Ganglion    292.5 Adult Crop    210.3 Adult Midgut    664.2 Adult Hindgut    229.7 Adult Malpighian Tubules    304.6 Adult Fat Body    59.8 Adult Salivary Gland    171.9 Adult Heart    75.95 Adult VirginFemale Spermatheca    118.2 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    41.5 Adult Testis    73.1 Adult Male Accessory Gland    123 Adult Carcass    82.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    469.8 Larval Midgut    891 Larval Hindgut    665 Larval Malpighian Tubules    469.3 Larval Fat Body    70.8 Larval Salivary Gland    183.1 Larval Trachea    336.85 Larval Carcass    385.7 Adult Head    141.8 Adult Eye    218.975 Adult Brain    356.7 Adult Thoracic-Abdominal Ganglion    292.5 Adult Crop    210.3 Adult Midgut    664.2 Adult Hindgut    229.7 Adult Malpighian Tubules    304.6 Adult Fat Body    59.8 Adult Salivary Gland    171.9 Adult Heart    75.95 Adult VirginFemale Spermatheca    118.2 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    41.5 Adult Testis    73.1 Adult Male Accessory Gland    123 Adult Carcass    82.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    141.8   NA  Eye    218.975   NA  Brain    356.7   469.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    292.5   NA  Crop    210.3   891  Midgut    664.2   665  Hindgut    229.7   469.3  Malpighian Tubules    304.6   70.8  Fat Body    59.8   183.1  Salivary Gland    171.9   NA  Heart    75.95   336.85  Trachea    NA   NA  VirginFemale Spermatheca    118.2   NA  InseminatedFemale Spermatheca    196.1   NA  Ovary    41.5   NA  Testis    73.1   NA  Male Accessory Gland    123   385.7  Carcass    82.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    15 digestive system, 20-day adult    42 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    10 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    15 digestive system, 20-day adult  (42) fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    10 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    15 digestive system, 20-day adult    42 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    10 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    15 digestive system, 20-day adult    42 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    10 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    15 digestive system, 20-day adult    42 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    10 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    15 digestive system, 20-day adult  (42) fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    10 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    15 digestive system, 20-day adult    42 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    10 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    15 digestive system, 20-day adult    42 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    10 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    36 embryo 04-06hr    45 embryo 06-08hr    63 embryo 08-10hr    56 embryo 10-12hr    37 embryo 12-14hr    21 embryo 14-16hr    23 embryo 16-18hr    17 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    13 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    7 adult male 05day    10 adult male 30day    13 adult female 01day    8 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr  (36) embryo 04-06hr  (45) embryo 06-08hr  (63) embryo 08-10hr  (56) embryo 10-12hr  (37) embryo 12-14hr    21 embryo 14-16hr    23 embryo 16-18hr    17 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    13 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    7 adult male 05day    10 adult male 30day    13 adult female 01day    8 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    36 embryo 04-06hr    45 embryo 06-08hr    63 embryo 08-10hr    56 embryo 10-12hr    37 embryo 12-14hr    21 embryo 14-16hr    23 embryo 16-18hr    17 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    13 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    7 adult male 05day    10 adult male 30day    13 adult female 01day    8 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    36 embryo 04-06hr    45 embryo 06-08hr    63 embryo 08-10hr    56 embryo 10-12hr    37 embryo 12-14hr    21 embryo 14-16hr    23 embryo 16-18hr    17 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    13 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    7 adult male 05day    10 adult male 30day    13 adult female 01day    8 adult female 05day    4 adult female 30day    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    36 embryo 04-06hr    45 embryo 06-08hr    63 embryo 08-10hr    56 embryo 10-12hr    37 embryo 12-14hr    21 embryo 14-16hr    23 embryo 16-18hr    17 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    13 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    7 adult male 05day    10 adult male 30day    13 adult female 01day    8 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr  (36) embryo 04-06hr  (45) embryo 06-08hr  (63) embryo 08-10hr  (56) embryo 10-12hr  (37) embryo 12-14hr    21 embryo 14-16hr    23 embryo 16-18hr    17 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    13 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    7 adult male 05day    10 adult male 30day    13 adult female 01day    8 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    36 embryo 04-06hr    45 embryo 06-08hr    63 embryo 08-10hr    56 embryo 10-12hr    37 embryo 12-14hr    21 embryo 14-16hr    23 embryo 16-18hr    17 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    13 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    7 adult male 05day    10 adult male 30day    13 adult female 01day    8 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    36 embryo 04-06hr    45 embryo 06-08hr    63 embryo 08-10hr    56 embryo 10-12hr    37 embryo 12-14hr    21 embryo 14-16hr    23 embryo 16-18hr    17 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    13 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    7 adult male 05day    10 adult male 30day    13 adult female 01day    8 adult female 05day    4 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    22 embryonic 1182-4H    24 embryonic GM2    111 embryonic Kc167    89 embryonic S1    142 embryonic S3    6 leg disc CME L1    29 wing disc CME-W2    43 wing disc ML-DmD8    27 wing disc ML-DmD9    54 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    22 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    79 ovary fGS/OSS    20 ovary OSC    31 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    22 embryonic 1182-4H    24 embryonic GM2  (111) embryonic Kc167  (89) embryonic S1  (142) embryonic S3    6 leg disc CME L1  (29) wing disc CME-W2  (43) wing disc ML-DmD8  (27) wing disc ML-DmD9  (54) wing disc ML-DmD16-c3    22 wing disc ML-DmD21    22 wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11  (39) antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1  (34) CNS ML-DmBG2-c2  (77) tumorous blood cells mbn2  (79) ovary fGS/OSS    20 ovary OSC  (31) ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    22 embryonic 1182-4H    24 embryonic GM2  (111) embryonic Kc167    89 embryonic S1  (142) embryonic S3    6 leg disc CME L1    29 wing disc CME-W2    43 wing disc ML-DmD8    27 wing disc ML-DmD9    54 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    22 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    79 ovary fGS/OSS    20 ovary OSC    31 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    22 embryonic 1182-4H    24 embryonic GM2    111 embryonic Kc167    89 embryonic S1    142 embryonic S3    6 leg disc CME L1    29 wing disc CME-W2    43 wing disc ML-DmD8    27 wing disc ML-DmD9    54 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    22 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    79 ovary fGS/OSS    20 ovary OSC    31 ovary OSS    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    22 embryonic 1182-4H    24 embryonic GM2    111 embryonic Kc167    89 embryonic S1    142 embryonic S3    6 leg disc CME L1    29 wing disc CME-W2    43 wing disc ML-DmD8    27 wing disc ML-DmD9    54 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    22 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    79 ovary fGS/OSS    20 ovary OSC    31 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    22 embryonic 1182-4H    24 embryonic GM2  (111) embryonic Kc167  (89) embryonic S1  (142) embryonic S3    6 leg disc CME L1  29 wing disc CME-W2  (43) wing disc ML-DmD8  27 wing disc ML-DmD9  (54) wing disc ML-DmD16-c3    22 wing disc ML-DmD21    22 wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11  (39) antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1  (34) CNS ML-DmBG2-c2  (77) tumorous blood cells mbn2  (79) ovary fGS/OSS    20 ovary OSC  31 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    22 embryonic 1182-4H    24 embryonic GM2  111 embryonic Kc167    89 embryonic S1  142 embryonic S3    6 leg disc CME L1    29 wing disc CME-W2    43 wing disc ML-DmD8    27 wing disc ML-DmD9    54 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    22 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    79 ovary fGS/OSS    20 ovary OSC    31 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    22 embryonic 1182-4H    24 embryonic GM2    111 embryonic Kc167    89 embryonic S1    142 embryonic S3    6 leg disc CME L1    29 wing disc CME-W2    43 wing disc ML-DmD8    27 wing disc ML-DmD9    54 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    22 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    79 ovary fGS/OSS    20 ovary OSC    31 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (53) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (53) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • PC00301 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041184 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15154-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | partially | pharate adult stage, with Scer\GAL4en-e16E Socs36EScer\UAS.P\T.cCa viable Socs36EEY11 Socs36EEY06665 Socs36EPZ1647 viable (with Df(2L)T317) Socs36EEY06665 Sterility Allele fertile Socs36EEY06665 Socs36EPZ1647 male semi-sterile (with Df(2L)T317) Socs36EEY06665 Other Phenotypes Allele memory defective | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch Socs36EScer\UAS.P\T.cCa short lived, with Scer\GAL4Act5C.PI Socs36EScer\UAS.P\T.cCa visible Socs36EEY11 visible, with Scer\GAL4ap-md544 Socs36EScer\UAS.P\T.cCa visible, with Scer\GAL4en-e16E Socs36EScer\UAS.cRa Socs36EScer\UAS.P\T.cCa visible, with Scer\GAL4hs.2sev Socs36EScer\UAS.P\T.cCa Phenotype manifest in Allele anterior crossvein, with Scer\GAL4en-e16E Socs36EΔSB.Scer\UAS.P\T Socs36EScer\UAS.P\T.cCa Socs36EScer\UAS.cRa border follicle cell, with Scer\GAL4c306 Socs36EΔSB.Scer\UAS.P\T Socs36EScer\UAS.P\T.cCa border follicle cell, with Scer\GAL4slbo.2.6 Socs36EScer\UAS.P\T.cCa cyst progenitor cell | male Socs36EEY06665 cyst progenitor cell | male | somatic clone Socs36EEY06665 cyst progenitor cell | somatic clone Socs36EPZ1647 eye Socs36EEY11 germline cell | embryonic stage | male, with Scer\GAL4nos.UTR.T:Hsim\VP16 Socs36EScer\UAS.P\T.cCa haltere, with Scer\GAL4en-e16E Socs36EΔSB.Scer\UAS.P\T Socs36EScer\UAS.P\T.cCa humerus, with Scer\GAL4en-e16E Socs36EΔSB.Scer\UAS.P\T Socs36EScer\UAS.P\T.cCa male germline stem cell Socs36EEY06665 Socs36EPZ1647 male germline stem cell (with Df(2L)M36F-S5) Socs36EPZ1647 photoreceptor cell R7, with Scer\GAL4hs.2sev Socs36EScer\UAS.P\T.cCa photoreceptor cell R7 | supernumerary Socs36EEY11 photoreceptor cell R7 | supernumerary, with Scer\GAL4GMR.PF Socs36EGD8929 photoreceptor cell R7 | supernumerary, with Scer\GAL4hs.2sev Socs36EGD8929 photoreceptor cell R7 | supernumerary (with Df(2L)Exel7070) Socs36EEY11 pigment cell, with Scer\GAL4en-e16E Socs36ESH2.Scer\UAS.P\T Socs36EScer\UAS.P\T.cCa wing, with Scer\GAL4Act5C.PI Socs36EScer\UAS.P\T.cCa wing, with Scer\GAL4ap-md544 Socs36EScer\UAS.P\T.cCa wing vein, with Scer\GAL4Act5C.PI Socs36EScer\UAS.P\T.cCa wing vein | ectopic, with Scer\GAL4en-e16E Socs36EScer\UAS.cRa
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Socs36E Class Mutagen Stocks Known lesion Socs36EEY06665 amorphic allele - molecular evidence P-element activity 1 Yes Socs36ECB-5235-3 1 -- Socs36ECB-6720-3 1 -- Socs36EG2762 P-element activity 1 -- Socs36EMI01068 1 -- Socs36EMI02672 1 -- Socs36ENP5170 1 Yes Socs36E34-120y+ 0 Yes Socs36E34-120y- cre recombinase 0 Yes Socs36EEY11 loss of function allele Delta2-3 0 Yes Socs36EPZ1647 loss of function allele P-element activity 0 Yes Socs36Erv1 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Socs36E Class Mutagen Stocks Known lesion Socs36EGD8929 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Socs36EHMS01450 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Socs36EAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Socs36EdsRNA.cMa in vitro construct - RNAi 0 -- Socs36ENIG.15154R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Socs36EScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes Socs36EScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes Socs36EScer\UAS.P\T.cCa in vitro construct - regulatory fusion 0 Yes Socs36ESH2.Scer\UAS.P\T in vitro construct - amino acid replacement 0 Yes Socs36EΔSB.Scer\UAS.P\T in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7070 (Ryder, 2004.4.26) Df(2L)Exel8038 (Ryder, 2004.4.26) Df(2L)M36F-S5 (Issigonis et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8929} NA P{NIG.15154R} NA P{TRiP.HMS01450} NA P{UASp-Socs36E.C} NA P{UASp-Socs36E.SH2} NA P{UASp-Socs36E.ΔSB} NA P{UAS-Socs36E.C} NA P{UAS-Socs36E.R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Socs36EG2762 NA P{EPgy2}Socs36EEY06665 NA miscellaneous insertions Mi{MIC}Socs36EMI01068 NA Mi{MIC}Socs36EMI02672 NA P{?EPgy2}Socs36EEY11 NA P{EP.Scer\UAS.(-loxP).BN}Socs36E34-120y- NA P{EP.Scer\UAS(loxP.Scer\UAS.y+).BN}Socs36E34-120y+ NA P{RS3}Socs36ECB-5235-3 NA P{RS3}Socs36ECB-6720-3 NA insertion of enhancer trap binary system P{GawB}Socs36ENP5170 No insertion of enhancer trap P{PZ}Socs36EPZ1647 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye pigmentation inferred from mutant phenotype (Callus and Mathey-Prevot, 2002) germ-line stem cell maintenance inferred from mutant phenotype (Issigonis et al., 2009, Singh et al., 2010) haltere development inferred from mutant phenotype (Callus and Mathey-Prevot, 2002) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Callus and Mathey-Prevot, 2002) long-term memory inferred from mutant phenotype (Copf et al., 2011) negative regulation of epidermal growth factor receptor signaling pathway inferred from mutant phenotype (Callus and Mathey-Prevot, 2002) negative regulation of JAK-STAT cascade inferred from genetic interaction with Stat92E (Singh et al., 2010) inferred from mutant phenotype (Callus and Mathey-Prevot, 2002) negative regulation of R7 cell differentiation inferred from genetic interaction with sev (Almudi et al., 2010) negative regulation of sevenless signaling pathway inferred from genetic interaction with sev (Almudi et al., 2009) notum morphogenesis inferred from mutant phenotype (Callus and Mathey-Prevot, 2002)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
JAK-STAT cascade non-traceable author statement (Rennebeck, 2001.10.18) regulation of JAK-STAT cascade traceable author statement (Castelli-Gair Hombria and Brown, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Socs36E allele Gene References unspecified Cbl (Callus and Mathey-Prevot, 2002) Egfr (Callus and Mathey-Prevot, 2002) hop (Callus and Mathey-Prevot, 2002) os (Bach et al., 2003) Stat92E (Callus and Mathey-Prevot, 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61081 DroID - A comprehensive database of gene and protein interactions. • FBgn0041184 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35085 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q86P82
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JWW0B Dipteran inclusive ortholog search EOG6X3H8V Insect inclusive ortholog search EOG6Z358X Arthropod inclusive ortholog search EOG61JWTC Metazoa inclusive ortholog search EOG6RJTTX
Orthologs in Drosophila Species (EOG6JWW0B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Socs36E     Drosophila simulans   Dsim\GD21843 Y   Drosophila sechellia   Dsec\GM17100 Y   Drosophila erecta   Dere\GG21718 Y   Drosophila yakuba   Dyak\GE12743 Y   Drosophila ananassae   Dana\GF15083 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13535 Y   Drosophila persimilis   Dper\GL15762 Y   Drosophila willistoni   Dwil\GK18209 Y   Drosophila virilis   Dvir\GJ10286 Y   Drosophila mojavensis   Dmoj\GI15810 Y
Orthologs in non-Drosophila Dipterans (EOG6X3H8V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000393   Anopheles gambiae Malaria mosquito  Agam\AGAP011042   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003380   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003379
Orthologs in non-Dipteran Insects (EOG6Z358X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55283   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004312   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13280   Atta cephalotes Leafcutter ant  Acep\ACEP26572   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16097   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21164   Linepithema humile Argentine ant  Lhum\LH20897   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23354   Solenopsis invicta Red fire ant  Sinv\SINV19936   Solenopsis invicta Red fire ant  Sinv\SINV19923   Solenopsis invicta Red fire ant  Sinv\SINV19940   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003795   Bombyx mori Silkmoth  Bmor\BGIBMGA009619   Pediculus humanus Human body louse  Phum\PHUM164470   Tribolium castaneum Red flour beetle  Tcas\TC003596
Orthologs in non-Insect Arthropods (EOG61JWTC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_307347   Ixodes scapularis Deer tick  Isca\ISCW004481
Orthologs in non-Arthropod Metazoa (EOG6RJTTX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026496gn   Danio rerio Zebrafish  Drer\socs5b   Danio rerio Zebrafish  Drer\socs5a   Xenopus tropicalis Western clawed frog  Xtro\socs5   Xenopus tropicalis Western clawed frog  Xtro\socs4   Gallus gallus Domestic chicken  Ggal\SOCS5   Gallus gallus Domestic chicken  Ggal\SOCS4   Mus musculus House mouse  Mmus\Socs5   Mus musculus House mouse  Mmus\Socs4   Rattus norvegicus Norway rat  Rnor\Socs4   Rattus norvegicus Norway rat  Rnor\Socs5   Homo sapiens Human  Hsap\DKFZp686J1568   Homo sapiens Human  Hsap\SOCS5
Human Orthologs (2)
Gene OMIM HGNC Hsap\DKFZp686J1568     Hsap\SOCS5
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21843 Drosophila sechellia Dsec\GM17100 Drosophila erecta Dere\GG21718 Drosophila yakuba Dyak\GE12743 Drosophila ananassae Dana\GF15083 Drosophila pseudoobscura pseudoobscura Dpse\GA13535 Drosophila persimilis Dper\GL15762 Drosophila willistoni Dwil\GK18209 Drosophila virilis Dvir\GJ10286 Drosophila mojavensis Dmoj\GI15810 Drosophila grimshawi Dgri\GH11180
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	27006 y1 w*; P{EP}Socs36EG2762 33106 y1 w*; Mi{MIC}Socs36EMI01068 35896 y1 w*; Mi{MIC}Socs36EMI02672 35036 y1 sc* v1; P{TRiP.HMS01450}attP2 16744 y1 w67c23; P{EPgy2}Socs36EEY06665
Kyoto	123522 w1118; P{RS3}Socs36ECB-5235-3 124194 w1118; P{RS3}Socs36ECB-6720-3 104883 y* w*; P{GawB}Socs36ENP5170 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v51821 w1118; P{GD8929}v51821 v52182 w1118; P{GD8929}v52182/CyO
Genomic Clones ( 1 )
	BACR39D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 61 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD04308
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD22121 LD30009 LP23890 RE12549 RE15518 RE19120 RE61259 RE69011 RH19135 RH67653 RH67677 RH70884 SD04320 SD07281 SD09184 SD10194 SD18129
Other clones	1572 45633 55297 67640 67662 72129 103161 190921 214543.21 AI124294 CK01.61C.H3 CK01.77C.A10 CK01.96B.F12 CK01.96D.B4 CK01.103A.H1 CK01.130C.A12 EK002907 EK048530 EK060435 EK074756 EK075138 EK086629 EK100227 EK122448 EK132813 EK149107 EK195647 EK195818 EK202819 EK226227 EK293527 EP15007 EP15139 FGC011D11 FGM103C01 FGM301D08 RE25607 RH63632 RP004109018 RP004407831 RP004464870 RP004472464 UUGC0579
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041184 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35085
Antibody Information
	polyclonal (Singh et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Socs36E Socs (Harrison, 2001.3.9)
Source for database merge of	Source for merge of: Socs36E anon-EST:Liang-2.2 (Ashburner, 2004.6.30) Source for merge of: Socs36E CG15154 (Harrison, 2001.3.9)
Additional comments
Other Comments
	Somatic Socs36E non-autonomously regulates the self-renewal of germline stem cells in the testis. (Singh et al., 2010) Socs36E suppresses JAK/STAT signalling in somatic cyst progenitor cells in the testis, preventing them from out-competing the germline stem cells. (Singh et al., 2010) Socs36E acts as an attenuator of sev signaling in the developing eye. (Almudi et al., 2009) dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway. (Mukherjee et al., 2006) Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against Socs36E results in a 3-fold increase in JAK/STAT activity. (Baeg et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078869 NM_165243 NM_001273605 NM_001273606 RefSeq (Proteins) • NP_523593 NP_724096 NP_001260534 NP_001260535 DDBJ / EMBL / GenBank • AAF53652 AAL30823 AAL30824 AAN11183 AAO39436 AC006471 AF435838 AF435839 AGB93069 AGB93070 AI124294 AI532714 AW944356 BT003433 CL527927 Entrez Gene - A searchable database of RefSeq genes. • 35085 UniProtKB/TrEMBL • Q8INY1 Q8WTC2 Q9VJA1 Q86P82
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SH2 domain (IPR000980) SOCS protein, C-terminal (IPR001496) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00301
Linkouts
	BioGRID - A database of protein and genetic interactions • 61081 DroID - A comprehensive database of gene and protein interactions. • FBgn0041184 DRSC - Results from RNAi screens. • FBgn0041184 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041184 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15154-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041184 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35085 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35085 modMine - Data generated by the modENCODE project. • FBgn0041184 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q86P82
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	anon-EST:Liang-2.2   CG15154 (Vodovar et al., 2005, Ashburner, 2004.6.30, Harrison, 2001.11.1, Pal et al., 2007, Hong et al., 2009, Ni et al., 2011.7.19, Vidal et al., 2010) clone 2.2 (Liang and Biggin, 1998) dmSocs36E (Kile et al., 2002) dSOCS (Rennebeck et al., 2000) SOCS (Zeidler et al., 2000, Castelli-Gair Hombria and Brown, 2002) Socs (Rennebeck, 2000.3.3, Bruckner et al., 2004) SOCS36E (Baeg et al., 2005, Bach et al., 2003, Rawlings et al., 2003, Karsten et al., 2002, Guo and Harrison, 2007, Sheng et al., 2009, Classen et al., 2009, Grönholm et al., 2012) socs36E (Callus and Mathey-Prevot, 2002, Muller et al., 2005, Rennebeck et al., 2002, Harrison, 2001.11.1, Galasso et al., 2005, Issigonis et al., 2007, Terry et al., 2006, Arbouzova et al., 2006, Castelli-Gair Hombria, 2006, Mukherjee et al., 2006, Almudí et al., 2007, Singh et al., 2010, Arbouzova and Zeidler, 2006, Issigonis et al., 2008, Liu et al., 2009, Flaherty et al., 2009, Issigonis et al., 2009, Bina et al., 2010, Wright et al., 2011, Vidal et al., 2010, Paredes et al., 2011) Socs36E (Pal et al., 2007, Kula-Eversole and Hatini, 2007, Nurminsky, 2007, Copf et al., 2011, Bach et al., 2007, Ma et al., 2006, Baeg et al., 2007, Johnson et al., 2011, Colodner and Feany, 2010, Jungreis et al., 2011, Wawersik et al., 2005, Rawlings et al., 2004, Almudi et al., 2009, Buchon et al., 2009, Buchon et al., 2009, Jiang et al., 2009, Almudi et al., 2010, Friedman et al., 2011, Buchon et al., 2010, Jiang et al., 2011, Rincon-Arano et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Grönholm et al., 2012, Chakrabarti et al., 2012) SocS36E (Opota et al., 2011) socs36e (Shaw et al., 2010) socs60E1 (Wang et al., 2004)
Name Synonym	CG15154 (Terry et al., 2006) Suppressor of cytokine signaling (Rennebeck et al., 2000) suppressor of cytokine signaling (Almudí et al., 2007) suppressor of cytokine signaling 36E (Sheng et al., 2009) Suppressor of cytokine signaling 36E (Issigonis et al., 2009) Suppressor of cytokine signaling at 36E (Harrison, 2001.3.9, Rawlings and Harrison, 2001)
Secondary FlyBase IDs
	FBgn0025963 FBgn0032667
References ( 103 )
Generate a list of	All references relating to this gene ( 103 )
List References by type	Research paper  ( 53 ) Supplementary material  ( 6 ) Review  ( 6 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 15 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 17 )
	Housden et al., 2013, PLoS Genet. 9(1): e1003162 Transcriptional Dynamics Elicited by a Short Pulse of Notch Activation Involves Feed-Forward Regulation by E(spl)/Hes Genes. [FBrf0220474] Tarayrah et al., 2013, Development 140(5): 1014--1023 Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche. [FBrf0220815] Chakrabarti et al., 2012, Cell Host Microbe 12(1): 60--70 Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. [FBrf0218984] Fisher et al., 2012, BMC Genomics 13: 506 Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. [FBrf0220361] Grönholm et al., 2012, FASEB J. 26(3): 1239--1250 Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells. [FBrf0217636] Herranz et al., 2012, Genes Dev. 26(14): 1602--1611 Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. [FBrf0218898] Herranz et al., 2012, Curr. Biol. 22(8): 651--657 Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. [FBrf0220229] Issigonis and Matunis, 2012, Dev. Biol. 368(2): 181--192 The Drosophila BCL6 homolog ken and barbie promotes somatic stem cell self-renewal in the testis niche. [FBrf0218994] Rincon-Arano et al., 2012, Cell 151(6): 1214--1228 UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions. [FBrf0220189] Sinden et al., 2012, Dev. Biol. 372(1): 5--16 Jak-STAT regulation of cyst stem cell development in the Drosophila testis. [FBrf0219716] Copf et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 8059--8064 Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. [FBrf0213703] Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Johnson et al., 2011, Development 138(21): 4627--4638 JAK/Stat signaling regulates heart precursor diversification in Drosophila. [FBrf0216404] Opota et al., 2011, PLoS Pathog. 7(9): e1002259 Monalysin, a Novel ß-Pore-Forming Toxin from the Drosophila Pathogen Pseudomonas entomophila, Contributes to Host Intestinal Damage and Lethality. [FBrf0216341] Paredes et al., 2011, Immunity 35(5): 770--779 Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection. [FBrf0216727] Wright et al., 2011, Cell. Signal. 23(5): 920--927 Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. [FBrf0213113] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...