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General Information
Symbol
Dmel\Socs36E
Species
D. melanogaster
Name
Suppressor of cytokine signaling at 36E
Annotation Symbol
CG15154
Feature Type
FlyBase ID
FBgn0041184
Gene Model Status
Stock Availability
Gene Snapshot
Suppressor of cytokine signaling at 36E (Socs36E) encodes a negative regulator of the JAK/STAT and EGFR pathways. It is a transcriptional target of the product of Stat92E that mediates lysosomal degradation following pathway stimulation and inhibits basal pathway activity. [Date last reviewed: 2019-03-21]
Also Known As

Suppressor of cytokine signaling 36E, Socs

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:18,138,675..18,152,417 [-]
Recombination map

2-53

RefSeq locus
NT_033779 REGION:18138675..18152417
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Molecular Function (GO)
[Detailed GO annotations]
Summaries
Pathway (FlyBase)
Negative Regulators of JAK-STAT Signaling Pathway -
Negative regulators of JAK-STAT signaling down-regulate the pathway, attenuating transcriptional control by Stat92E.
Negative Regulators of Sevenless Signaling Pathway -
Negative regulators of Sevenless signaling down-regulate the pathway, directing the presumptive R7 cell fate to that of a cone cell. (Adapted from FBrf0127283 and FBrf0221727).
Negative Regulators of EGFR Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Summary (Interactive Fly)

inhibitor of JAK/STAT pathway, works vie a protein degradation pathway, cooperates with EGFR to regulate oncogenic transformation, optimizes motile cell specification in the ovary, regulator of niche competition in the testis, regulated by Histone demethylase

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Socs36E or the JBrowse view of Dmel\Socs36E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884.

gene_with_stop_codon_read_through ; SO:0000697

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0081040
3503
633
FBtr0329927
3334
633
FBtr0329928
3503
737
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0080593
68.9
633
7.39
FBpp0302959
68.9
633
7.39
FBpp0302960
80.3
737
6.85
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

633 aa isoforms: Socs36E-PA, Socs36E-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Socs36E using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (19 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:Q9VWE0
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000806614
(assigned by GO_Central )
Biological Process (15 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
inferred from genetic interaction with FLYBASE:bam; FB:FBgn0000158
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR036036
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000806614
(assigned by GO_Central )
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000806614
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
dorsal ectoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: paper states 2-24 hr AEL; expression weak after 12 hr AEL

Additional Descriptive Data

Expression of Socs36E in wild-type embryos is higher on the inside of the hindgut curve.

Socs36E and twi are expressed in a complementary pattern in the dorsal mesoderm in stage 10 embryos.

Socs36E transcript is expressed in a striped pattern similar to that of os through germ band extension. During oogenesis, Socs36E transcript is expressed in the polar follicle cells, and in the follicle cells near the polar follicle cells.

The 2.5 kb Socs36E transcript is observed in S2 cultured cells but not in vivo. Strong transcript expression is observed from embryonic stage 5 through stage 15 (2-13 hrs AEL). Weak expression is observed from late stage 15 through stage 17, and faint expression is observed in third instar larvae and in pupae. Early embryonic expression is observed in dorsal/ventral stripes. By stage 9, these stripes are mesodermal and segmentally repeated.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Socs36E protein is highly expressed in cyst cells in the testis.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
follicle cell

Comment: anterior and posterior follicle cells

Reporter: P{PZ}Socs36EPZ1647
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Socs36E in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Socs36E
Transgenic constructs containing regulatory region of Socs36E
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
Yes
7 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
Yes
7 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (7)
7 of 13
Yes
Yes
6 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (8)
7 of 12
Yes
Yes
6 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
No
2 of 12
No
No
2 of 12
No
Yes
2 of 12
No
No
Danio rerio (Zebrafish) (14)
8 of 15
Yes
Yes
7 of 15
No
Yes
6 of 15
No
Yes
4 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
2 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908MW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505T5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BH2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BEM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0EQ0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
3 of 10
3 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Negative Regulators of JAK-STAT Signaling Pathway -
Negative regulators of JAK-STAT signaling down-regulate the pathway, attenuating transcriptional control by Stat92E.
Negative Regulators of Sevenless Signaling Pathway -
Negative regulators of Sevenless signaling down-regulate the pathway, directing the presumptive R7 cell fate to that of a cone cell. (Adapted from FBrf0127283 and FBrf0221727).
Negative Regulators of EGFR Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Metabolic Pathways
External Data
Linkouts
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map

2-53

Cytogenetic map
Sequence location
2L:18,138,675..18,152,417 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
36E6-36E6
Limits computationally determined from genome sequence between P{lacW}Aac11k06710 and P{EP}CG10413EP2164
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (15)
Genomic Clones (20)
cDNA Clones (57)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: Socs36E Socs

    Source for database merge of

    Source for merge of: Socs36E anon- EST:Liang-2.2

    Source for merge of: Socs36E CG15154

    Additional comments
    Other Comments

    Somatic Socs36E non-autonomously regulates the self-renewal of germline stem cells in the testis.

    Socs36E suppresses JAK/STAT signalling in somatic cyst progenitor cells in the testis, preventing them from out-competing the germline stem cells.

    Socs36E acts as an attenuator of sev signaling in the developing eye.

    dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway.

    Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against Socs36E results in a 3-fold increase in JAK/STAT activity.

    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 52 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (22)
    Reported As
    Symbol Synonym
    Socs36E
    (Feuillette et al., 2020, Hao et al., 2020, Herrera and Bach, 2019, Houtz et al., 2019, Moskalev et al., 2019, Nelson et al., 2019, Sanuki et al., 2019, Si et al., 2019, Singh et al., 2019, Troha and Buchon, 2019, Wang et al., 2019, Wittes and Schüpbach, 2019, Bazzi et al., 2018, Gene Disruption Project members, 2018-, La Fortezza et al., 2018, Kline et al., 2017, Takemura and Nakato, 2017, Transgenic RNAi Project members, 2017-, Zhou et al., 2017, Clandinin and Owens, 2016-, Hoi et al., 2016, Kučerová et al., 2016, Monahan and Starz-Gaiano, 2016, Crona et al., 2015, Dorn and Dorn, 2015, Hamilton et al., 2015, Kavi et al., 2015, Kohlmaier et al., 2015, Merkling et al., 2015, Ren et al., 2015, Woodcock et al., 2015, Zhang et al., 2015, Zhou et al., 2015, Chabu and Xu, 2014, Chen et al., 2014, Cordero et al., 2014, Fernando et al., 2014, Guo et al., 2014, Huang et al., 2014, Li et al., 2014, Markstein et al., 2014, Morelli et al., 2014, Salazar-Jaramillo et al., 2014, Taylor et al., 2014, Wang et al., 2014, Bausek, 2013, Gunawan et al., 2013, Hombría and Serras, 2013, Hombría and Sotillos, 2013, Mbodj et al., 2013, Monahan and Starz-Gaiano, 2013, Morin-Poulard et al., 2013, Schertel et al., 2013, Wells et al., 2013, Zoranovic et al., 2013, Chakrabarti et al., 2012, Grönholm et al., 2012, Herranz et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Lim et al., 2012, Matunis et al., 2012, Osman et al., 2012, Rincon-Arano et al., 2012, Zoller and Schulz, 2012, Copf et al., 2011, de Cuevas and Matunis, 2011, Friedman et al., 2011, Friedman et al., 2011, Issigonis and Matunis, 2011, Jiang et al., 2011, Johnson et al., 2011, Jungreis et al., 2011, Kuraishi et al., 2011, Almudi et al., 2010, Buchon et al., 2010, Colodner and Feany, 2010, Almudi et al., 2009, Buchon et al., 2009, Buchon et al., 2009, Iovino et al., 2009, Jiang et al., 2009, Bach et al., 2007, Baeg et al., 2007, Kula-Eversole and Hatini, 2007, Nurminsky, 2007, Pal et al., 2007, Ma et al., 2006, Wawersik et al., 2005, Rawlings et al., 2004)
    anon-EST:Liang-2.2
    Name Synonyms
    Suppressor of Cytokine Signaling 36E
    Suppressor of cytokine signaling
    Suppressor of cytokine signaling 36E
    suppressor of cytokine signaling
    suppressor of cytokine signaling 36E
    Secondary FlyBase IDs
    • FBgn0025963
    • FBgn0032667
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (205)