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Gene Dmel\Slbp

General Information
Symbol	Dmel\Slbp	Species	D. melanogaster
Name	Stem-loop binding protein	Annotation symbol	CG11886
Feature type	protein_coding_gene	FlyBase ID	FBgn0041186
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	dSLBP
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98F13-98F13	Sequence location	3R:24,977,796..24,978,988 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Stem-loop binding protein is referred to in FlyBase by the symbol Dmel\Slbp (CG11886, FBgn0041186). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: mRNA binding; RNA stem-loop binding. There is experimental evidence that it is involved in the biological process: histone mRNA metabolic process; histone mRNA 3'-end processing; cell cycle. 19 alleles are reported. The phenotypes of these alleles are annotated with: mitotic cell cycle; nuclear chromosome. It has one annotated transcript and one annotated polypeptide. Protein features are: Histone RNA stem-loop-binding protein SLBP1/SLBP2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval salivary gland, larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1629406_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Slbp. Gene sequence location is 3R:24977796..24978988.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98F13-98F13   Limits computationally determined from genome sequence between P{EP}EP3390EP3390 and P{PZ}l(3)0470804708
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98F-98F     (Sullivan, 1999.8.12) 98F-98F     (Sullivan, 2000.4.19) 98F-98F     (Duronio, 2000.2.2)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Slbp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Slbp-RA FBtr0085409  NM_058132   1132   276
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Slbp-PA   FBpp0084778   30.6   276   9.19     NP_477480   AAF56867
Additional Polypeptide Data & Comments
Reported size (kDa)	276 (aa) (Sullivan et al., 2001)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Histone RNA stem-loop-binding protein SLBP1/SLBP2 (IPR026502)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695071   AA801749   AA802593   AA802944   AE014297 AAF56867   AC007855   AF186594 AAG16723   AF258617 AAF71752   AQ025158   AQ073799   AY089675 AAL90413   AY118836 AAM50696   BF504386   BH634808   BI232367   BI232886   BI351986   BI352812   BI483842   BI484995   BI616905   BI635589   BI635915   BI640233   CO310776   CO312768   DN154098   EC053812   EC213826   EC227076   EV577128   GH739359   GH740708   GH741076   GH743718   GH744094   GH745141   GH745356   GH746734   GH747257   GH762089   GH763302   GH764801   GH767571   GH769151   GH769541   GH769574
UniProtKB/Swiss-Prot	Q9VAN6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic central brain surface glia   (Fisher et al., 2012) embryonic ganglion mother cell   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) lateral cord surface glial cell   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) procephalic neuroblast   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic central brain surface glia   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) lateral cord surface glial cell   (Fisher et al., 2012) mushroom body primordium   (Fisher et al., 2012) Comment:reported as embryonic central brain mushroom body organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) pcr Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Sullivan et al., 2001) pre-blastoderm stage   organism   (Sullivan et al., 2001) embryonic stage 5 -- 12   organism | ubiquitous   (Sullivan et al., 2001) embryonic stage 11 -- 17   presumptive embryonic/larval peripheral nervous system   (Sullivan et al., 2001) presumptive embryonic/larval central nervous system   (Sullivan et al., 2001) embryonic stage 13 -- 17   embryonic/larval midgut primordium   (Sullivan et al., 2001)
Additional Descriptive Data
	Slbp transcript is detected in all developmental stages, with highest amounts in 0-8 hr embryos and adult females. Maternal Slbp transcript disappears by the end of the syncytial blastoderm stage. Ubiquitous zygotic expression begins at the cellular blastoderm stage, and is maintained during early germ-band extension. At later stages, expression decreases in G1 arrested cells and is restricted to proliferating and endoreduplicating cells. (Sullivan et al., 2001)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Lanzotti et al., 2004) nucleus inferred from direct assay (Lanzotti et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval salivary gland, larval trachea, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary  (655.2) Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary  655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    79.2   NA  Eye    77.275   NA  Brain    132.9   304.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    107.3   NA  Crop    105.8   42.1  Midgut    51.7   65.4  Hindgut    57   39.1  Malpighian Tubules    30.3   57.4  Fat Body    82.3   149.2  Salivary Gland    94.8   NA  Heart    66.45   147.45  Trachea    NA   NA  VirginFemale Spermatheca    37   NA  InseminatedFemale Spermatheca    43.7   NA  Ovary    655.2   NA  Testis    215   NA  Male Accessory Gland    71.9   94.25  Carcass    84.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    31 central nervous system, pupae P8    7 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    5 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    13 carcass, larvae L3 wandering    19 carcass, 1-day adult    8 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    130 ovary, mated 4-day female    128 testis, mated 4-day male    63 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  (31) central nervous system, pupae P8    7 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    5 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    13 carcass, larvae L3 wandering    19 carcass, 1-day adult    8 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female  (130) ovary, mated 4-day female  (128) testis, mated 4-day male  (63) accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    31 central nervous system, pupae P8    7 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    5 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    13 carcass, larvae L3 wandering    19 carcass, 1-day adult    8 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female  (130) ovary, mated 4-day female  (128) testis, mated 4-day male    63 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    31 central nervous system, pupae P8    7 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    5 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    13 carcass, larvae L3 wandering    19 carcass, 1-day adult    8 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    130 ovary, mated 4-day female    128 testis, mated 4-day male    63 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    31 central nervous system, pupae P8    7 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    5 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    13 carcass, larvae L3 wandering    19 carcass, 1-day adult    8 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    130 ovary, mated 4-day female    128 testis, mated 4-day male    63 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  31 central nervous system, pupae P8    7 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    5 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    13 carcass, larvae L3 wandering    19 carcass, 1-day adult    8 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female  (130) ovary, mated 4-day female  (128) testis, mated 4-day male  (63) accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    31 central nervous system, pupae P8    7 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    5 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    13 carcass, larvae L3 wandering    19 carcass, 1-day adult    8 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female  130 ovary, mated 4-day female  128 testis, mated 4-day male    63 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    31 central nervous system, pupae P8    7 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    5 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    13 carcass, larvae L3 wandering    19 carcass, 1-day adult    8 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    130 ovary, mated 4-day female    128 testis, mated 4-day male    63 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    134 embryo 02-04hr    157 embryo 04-06hr    246 embryo 06-08hr    132 embryo 08-10hr    64 embryo 10-12hr    35 embryo 12-14hr    16 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    18 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    13 white prepupae 12hr    21 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    11 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    25 adult male 30day    22 adult female 01day    33 adult female 05day    65 adult female 30day    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (134) embryo 02-04hr  (157) embryo 04-06hr  (246) embryo 06-08hr  (132) embryo 08-10hr  (64) embryo 10-12hr  (35) embryo 12-14hr    16 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    18 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    13 white prepupae 12hr    21 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    11 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    25 adult male 30day    22 adult female 01day  (33) adult female 05day  (65) adult female 30day  (76) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (134) embryo 02-04hr  (157) embryo 04-06hr  (246) embryo 06-08hr  (132) embryo 08-10hr    64 embryo 10-12hr    35 embryo 12-14hr    16 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    18 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    13 white prepupae 12hr    21 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    11 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    25 adult male 30day    22 adult female 01day    33 adult female 05day    65 adult female 30day    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    134 embryo 02-04hr    157 embryo 04-06hr    246 embryo 06-08hr    132 embryo 08-10hr    64 embryo 10-12hr    35 embryo 12-14hr    16 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    18 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    13 white prepupae 12hr    21 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    11 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    25 adult male 30day    22 adult female 01day    33 adult female 05day    65 adult female 30day    76 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    134 embryo 02-04hr    157 embryo 04-06hr    246 embryo 06-08hr    132 embryo 08-10hr    64 embryo 10-12hr    35 embryo 12-14hr    16 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    18 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    13 white prepupae 12hr    21 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    11 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    25 adult male 30day    22 adult female 01day    33 adult female 05day    65 adult female 30day    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (134) embryo 02-04hr  (157) embryo 04-06hr  (246) embryo 06-08hr  (132) embryo 08-10hr  (64) embryo 10-12hr  (35) embryo 12-14hr    16 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    18 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    13 white prepupae 12hr    21 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    11 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    25 adult male 30day    22 adult female 01day  (33) adult female 05day  (65) adult female 30day  (76) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  134 embryo 02-04hr  (157) embryo 04-06hr  (246) embryo 06-08hr  132 embryo 08-10hr    64 embryo 10-12hr    35 embryo 12-14hr    16 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    18 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    13 white prepupae 12hr    21 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    11 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    25 adult male 30day    22 adult female 01day    33 adult female 05day    65 adult female 30day    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    134 embryo 02-04hr    157 embryo 04-06hr    246 embryo 06-08hr    132 embryo 08-10hr    64 embryo 10-12hr    35 embryo 12-14hr    16 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    18 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    13 white prepupae 12hr    21 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    11 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    25 adult male 30day    22 adult female 01day    33 adult female 05day    65 adult female 30day    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    104 Schneider line 2 Sg4    35 embryonic 1182-4H    48 embryonic GM2    30 embryonic Kc167    40 embryonic S1    49 embryonic S3    37 leg disc CME L1    42 wing disc CME-W2    18 wing disc ML-DmD8    31 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    122 ovary OSC    22 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (104) Schneider line 2 Sg4  (35) embryonic 1182-4H  (48) embryonic GM2  (30) embryonic Kc167  (40) embryonic S1  (49) embryonic S3  (37) leg disc CME L1  (42) wing disc CME-W2    18 wing disc ML-DmD8  (31) wing disc ML-DmD9  (48) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  (61) wing disc ML-DmD32  (46) haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  (46) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (66) CNS ML-DmBG2-c2    24 tumorous blood cells mbn2  (28) ovary fGS/OSS  (122) ovary OSC    22 ovary OSS  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  104 Schneider line 2 Sg4    35 embryonic 1182-4H    48 embryonic GM2    30 embryonic Kc167    40 embryonic S1    49 embryonic S3    37 leg disc CME L1    42 wing disc CME-W2    18 wing disc ML-DmD8    31 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS  (122) ovary OSC    22 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    104 Schneider line 2 Sg4    35 embryonic 1182-4H    48 embryonic GM2    30 embryonic Kc167    40 embryonic S1    49 embryonic S3    37 leg disc CME L1    42 wing disc CME-W2    18 wing disc ML-DmD8    31 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    122 ovary OSC    22 ovary OSS    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    104 Schneider line 2 Sg4    35 embryonic 1182-4H    48 embryonic GM2    30 embryonic Kc167    40 embryonic S1    49 embryonic S3    37 leg disc CME L1    42 wing disc CME-W2    18 wing disc ML-DmD8    31 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    122 ovary OSC    22 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (104) Schneider line 2 Sg4  (35) embryonic 1182-4H  (48) embryonic GM2  30 embryonic Kc167  (40) embryonic S1  (49) embryonic S3  (37) leg disc CME L1  (42) wing disc CME-W2    18 wing disc ML-DmD8  31 wing disc ML-DmD9  (48) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  (61) wing disc ML-DmD32  (46) haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  (46) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (66) CNS ML-DmBG2-c2    24 tumorous blood cells mbn2  28 ovary fGS/OSS  (122) ovary OSC    22 ovary OSS  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  104 Schneider line 2 Sg4    35 embryonic 1182-4H    48 embryonic GM2    30 embryonic Kc167    40 embryonic S1    49 embryonic S3    37 leg disc CME L1    42 wing disc CME-W2    18 wing disc ML-DmD8    31 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS  122 ovary OSC    22 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    104 Schneider line 2 Sg4    35 embryonic 1182-4H    48 embryonic GM2    30 embryonic Kc167    40 embryonic S1    49 embryonic S3    37 leg disc CME L1    42 wing disc CME-W2    18 wing disc ML-DmD8    31 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    122 ovary OSC    22 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    23 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult    115 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    83 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    109 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    54 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (36) cold shock, 4-day adult    23 heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult  (46) Cadmium 100 mM 48 hrs, 4-day adult  (115) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (83) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (109) Caffeine 25 mg/ml 48 hrs, 4-day adult  (39) Paraquat 5 mM 48 hrs, 4-day adult  (78) Paraquat 10 mM 48 hrs, 4-day adult  (54) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    23 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult  (115) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    83 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (109) Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    54 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    23 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult    115 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    83 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    109 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    54 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    23 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult    115 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    83 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    109 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    54 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (36) cold shock, 4-day adult    23 heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult  (46) Cadmium 100 mM 48 hrs, 4-day adult  (115) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (83) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (109) Caffeine 25 mg/ml 48 hrs, 4-day adult  (39) Paraquat 5 mM 48 hrs, 4-day adult  (78) Paraquat 10 mM 48 hrs, 4-day adult  (54) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    23 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult  115 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    83 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  109 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    54 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    23 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult    115 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    83 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    109 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    54 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • GM06606 RH47057 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041186 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11886-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Slbp Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Slbp12 Slbp15 lethal | maternal effect Slbp10 lethal | pupal stage Slbp15 lethal | recessive Slbp35 Slbp47 partially lethal - majority die Slbp19 partially lethal - majority die (with Slbp10) Slbp12 Slbp15 partially lethal - majority die (with Slbp12) Slbp10 partially lethal - majority die (with Slbp15) Slbp10 partially lethal - majority live Slbp10 viable, with Scer\GAL4[-]: SlbpEP1045 SlbpEP3182 viable, with Scer\GAL4pnr-MD237 SlbpGD7420 Sterility Allele female sterile Slbp10 Slbp19 female sterile (with Df(3R)3450) Slbp10 male fertile Slbp10 Slbp19 male fertile (with Df(3R)3450) Slbp10 Other Phenotypes Allele wild-type Slbp+tSa Phenotype manifest in Allele mitotic cell cycle Slbp10 nuclear chromosome Slbp10
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Slbp Class Mutagen Stocks Known lesion Slbp10 P-element activity 1 Yes Slbp15 loss of function allele P-element activity 1 Yes SlbpEP1045 P-element activity 1 Yes SlbpHP36916 1 -- SlbpUM-8085-3 1 -- SlbpUM-8128-3 1 -- Slbp12 P-element activity 0 Yes Slbp19 P-element activity 0 Yes Slbp35 P-element activity 0 -- Slbp47 P-element activity 0 -- SlbpEP3182 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Slbp Class Mutagen Stocks Known lesion SlbpGD7420 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes SlbpKK108617 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Slbp+tSa in vitro construct - genomic fragment 0 Yes SlbpNIG.11886R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SlbpT120A.T230A.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes SlbpT120A.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes SlbpT230A.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes SlbpWT.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)3450 (Sullivan et al., 2001) Df(3R)Slbp12 (Sullivan et al., 2001) Df(3R)stgAR2 (Lanzotti et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7420} NA P{KK108617} NA P{NIG.11886R} NA characterization construct P{Slbp.HA} NA P{Slbp.T120A.HA} NA P{Slbp.T120A.T230A.HA} NA P{Slbp.T230A.HA} NA P{Slbp+tSa} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}SlbpEP1045 NA P{EP}SlbpEP3182 NA P{EPg}SlbpHP36916 NA miscellaneous insertions P{EP-Δ10}Slbp10 NA P{EP-Δ15}Slbp15 NA P{EP-Δ19}Slbp19 NA P{RS3}SlbpUM-8085-3 NA P{RS3}SlbpUM-8128-3 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from mutant phenotype (Duronio et al., 2000) RNA stem-loop binding inferred from direct assay (Borchers et al., 2006)
Biological Process
CV term Evidence References
cell cycle inferred from mutant phenotype (Sullivan et al., 2001) histone mRNA 3'-end processing inferred from direct assay (Dominski et al., 2002) inferred from mutant phenotype (Sullivan et al., 2001, Lanzotti et al., 2004, Wagner et al., 2007, Godfrey et al., 2006, Sullivan et al., 2009) histone mRNA metabolic process inferred from mutant phenotype (Duronio et al., 2000)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Lanzotti et al., 2004) nucleus inferred from direct assay (Lanzotti et al., 2004)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mRNA binding non-traceable author statement (Sullivan, 2000.4.19)
Biological Process
CV term Evidence References
cell cycle non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) histone mRNA 3'-end processing non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Slbp - AnxB10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Slbp - CG10638 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Slbp - CG9436 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Slbp - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Slbp - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Slbp - Nacα experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Slbp - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Slbp - mus209 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Slbp - regucalcin experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Slbp allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041186 DroID - A comprehensive database of gene and protein interactions. • FBgn0041186 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43448
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6640ZD Dipteran inclusive ortholog search EOG6FN4SW Insect inclusive ortholog search EOG651CN3 Arthropod inclusive ortholog search EOG625491 Metazoa inclusive ortholog search EOG6TR046
Orthologs in Drosophila Species (EOG6640ZD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Slbp     Drosophila simulans   Dsim\GD15074 Y   Drosophila sechellia   Dsec\GM12257 Y   Drosophila erecta   Dere\GG12032 Y   Drosophila yakuba   Dyak\GE10470 Y   Drosophila ananassae   Dana\GF18411 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11260 Y   Drosophila persimilis   Dper\GL23600 Y   Drosophila willistoni   Dwil\GK22497 Y   Drosophila willistoni   Dwil\GK22498     Drosophila virilis   Dvir\GJ14235 Y   Drosophila mojavensis   Dmoj\GI22353 Y   Drosophila grimshawi   Dgri\GH23225     Drosophila grimshawi   Dgri\GH14009 Y   Drosophila grimshawi   Dgri\GH23223
Orthologs in non-Drosophila Dipterans (EOG6FN4SW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010422   Anopheles gambiae Malaria mosquito  Agam\AGAP012972   Anopheles gambiae Malaria mosquito  Agam\AGAP013023   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008644
Orthologs in non-Dipteran Insects (EOG651CN3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46213   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005729   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16620   Atta cephalotes Leafcutter ant  Acep\ACEP22735   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17764   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14105   Linepithema humile Argentine ant  Lhum\LH18156   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25271   Solenopsis invicta Red fire ant  Sinv\SINV22131   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001641   Bombyx mori Silkmoth  Bmor\BGIBMGA005486   Pediculus humanus Human body louse  Phum\PHUM317680   Tribolium castaneum Red flour beetle  Tcas\TC012536
Orthologs in non-Insect Arthropods (EOG625491)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\IQCE   Ixodes scapularis Deer tick  Isca\ISCW022471
Orthologs in non-Arthropod Metazoa (EOG6TR046)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cdl-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009593gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024780gn   Danio rerio Zebrafish  Drer\slbp   Danio rerio Zebrafish  Drer\zgc:158856   Xenopus tropicalis Western clawed frog  Xtro\slbp   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033144   Gallus gallus Domestic chicken  Ggal\LOC422901   Gallus gallus Domestic chicken  Ggal\SLBP   Mus musculus House mouse  Mmus\Slbp   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000037162   Homo sapiens Human  Hsap\SLBP
Human Orthologs (1)
Gene OMIM HGNC Hsap\SLBP
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15074 Drosophila sechellia Dsec\GM12257 Drosophila erecta Dere\GG12032 Drosophila yakuba Dyak\GE10470 Drosophila ananassae Dana\GF18411 Drosophila pseudoobscura pseudoobscura Dpse\GA11260 Drosophila persimilis Dper\GL23600 Drosophila willistoni Dwil\GK22497 Drosophila virilis Dvir\GJ14235 Drosophila mojavensis Dmoj\GI22353 Drosophila grimshawi Dgri\GH14009
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	17211 w1118; P{EP}SlbpEP1045/TM6B, Tb1 22127 w1118; P{EPg}SlbpHP36916/TM3, Ser1 34056 w*; Slbp10/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb1 Ser1 34057 w*; Slbp15/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb1 Ser1
Kyoto	124329 w1118; P{RS3}SlbpUM-8085-3 124360 w1118; P{RS3}SlbpUM-8128-3
VDRC	v100785 P{KK108617}VIE-260B v42970 w1118; P{GD7420}v42970 v42971 w1118; P{GD7420}v42971 v48746 w1118; P{GD7420}v48746
Genomic Clones ( 1 )
	BACR22E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM06606 RH47057
Other clones	DPiM_GM06606
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05738 GM02081 GM03444 GM05877 GM17123 GM20909 RE28422 RE29034 RE66792 RE68208 SD16979 SD17452 SD23044
Other clones	104851 164932 Dmel_dig_002399_0705_2273 EC053812 EK176828 EK222507 EK229941 RP001003678 RP001005766 RP001007162 RP001016340 RP001023644 RP001024841 RP001029521 RP001031776 RP001037765 RP001038086 RP001039142 RP001041465 RP001043833 RP001050363 RP001050402 RP001050923
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041186 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43448
Antibody Information
	polyclonal (Sullivan et al., 2001, Sullivan et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Slbp CG11886 (FlyBase, 1996-)
Additional comments	Source for merge of Slbp CG11886 was sequence comparison (date:000526). (FlyBase, 1996-)
Other Comments
	Mutant analysis shows that phosphorylation of Slbp at T230 is necessary for its localization to the cytoplasm and subsequent function in the 3'-end processing of histone mRNA. (Lanzotti et al., 2004) Slbp is required for 3' end processing of histone pre-mRNA. Overall orientation not stated: Pglym78+ ligatin- Slbp- Rpn2+ (Sullivan et al., 2001) Slbp-dependant processing plays an important role in coupling histone mRNA production with the cell cycle. (Sullivan et al., 2001) The pattern of histone mRNA accumulation is disrupted in mutant embryos. (Duronio et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058132 RefSeq (Proteins) • NP_477480 DDBJ / EMBL / GenBank • AA802944 AAF56867 AAF71752 AAG16723 AAL90413 AAM50696 AC007855 AF186594 AF258617 AQ025158 AQ073799 AY089675 AY118836 BH634808 BI616905 Entrez Gene - A searchable database of RefSeq genes. • 43448 UniProtKB/Swiss-Prot • Q9VAN6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Histone RNA stem-loop-binding protein SLBP1/SLBP2 (IPR026502) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM06606 RH47057
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041186 DroID - A comprehensive database of gene and protein interactions. • FBgn0041186 DRSC - Results from RNAi screens. • FBgn0041186 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041186 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11886-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041186 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43448 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43448 modMine - Data generated by the modENCODE project. • FBgn0041186
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG11886 (Brody et al., 2002, Keleman et al., 2009.8.5) dSLBP (Robertson et al., 2004, Thapar et al., 2004, Thapar et al., 2004, Kupsco et al., 2004, Dominski et al., 2003, Duronio et al., 2000, Yang et al., 2009, Dominski et al., 2002, Lanzotti et al., 2002, Borchers et al., 2006, Li et al., 2012, Li et al., 2012, Torres et al., 2005) dSLPB (Sullivan et al., 2001) SLBP (Godfrey et al., 2005, Wagner et al., 2007, Sofola et al., 2007, White et al., 2011, Ezzeddine et al., 2011, Tatomer et al., 2008, Wagner et al., 2008, Sullivan et al., 2009, Dominski et al., 2005, Godfrey et al., 2006, Kupsco et al., 2006) slbp (Orian et al., 2003, Sofola et al., 2007, Southall and Brand, 2009) Slbp (Lafave and Sekelsky, 2011, Wagner et al., 2007, White et al., 2007, Salzler et al., 2009, Bulchand et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Stem-loop binding protein (Duronio et al., 2000, Bulchand et al., 2010) stem-loop binding protein (Dominski et al., 2002, Tadros et al., 2007) stem loop binding protein (Wagner et al., 2007) Stem-Loop Binding Protein (Salzler et al., 2009, Torres et al., 2005) Stem Loop Binding Protein (Torres et al., 2005)
Secondary FlyBase IDs
	FBgn0039643
References ( 59 )
Generate a list of	All references relating to this gene ( 59 )
List References by type	Research paper  ( 32 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Conference report  ( 1 )
Recent research papers ( 5 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Li et al., 2012, Curr. Biol. 22(22): 2104--2113 Lipid droplets control the maternal histone supply of Drosophila embryos. [FBrf0220040] Ezzeddine et al., 2011, Mol. Cell. Biol. 31(2): 328--341 A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation. [FBrf0212592] Lafave and Sekelsky, 2011, Genetics 188(3): 749--752 Transcription Initiation From Within P Elements Generates Hypomorphic Mutations in Drosophila melanogaster. [FBrf0214251] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Show all research papers ...