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Gene Dmel\Slbp

General Information
Symbol	Dmel\Slbp	Species	D. melanogaster
Name	Stem-loop binding protein	Annotation symbol	CG11886
Feature type	protein_coding_gene	FlyBase ID	FBgn0041186
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	dSLBP
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98F13-98F13	Sequence location	3R:24,977,793..24,978,969 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Stem-loop binding protein is referred to in FlyBase by the symbol Dmel\Slbp (CG11886, FBgn0041186). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: mRNA binding; RNA stem-loop binding. There is experimental evidence that it is involved in the biological process: histone mRNA metabolic process; histone mRNA 3'-end processing; cell cycle. 18 alleles are reported. The phenotypes of these alleles are annotated with: mitotic cell cycle; nuclear chromosome. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval salivary gland, larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1629406_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Slbp. Gene sequence location is 3R:24977793..24978969.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN28617 HFA16863
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98F13-98F13   Limits computationally determined from genome sequence between P{EP}EP3390EP3390 and P{PZ}l(3)0470804708
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98F-98F     (Sullivan, 1999.8.12) 98F-98F     (Sullivan, 2000.4.19) 98F-98F     (Duronio, 2000.2.2)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Slbp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Slbp-RA FBtr0085409  NM_058132   1116   276
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Slbp-PA   FBpp0084778   30.6   276   9.19     NP_477480   AAF56867
Additional Polypeptide Data & Comments
Reported size (kDa)	276 (aa) (Sullivan et al., 2001)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695071   AA801749   AA802593   AA802944   AE014297 AAF56867   AC007855   AF186594 AAG16723   AF258617 AAF71752   AQ025158   AQ073799   AY089675 AAL90413   AY118836 AAM50696   BF504386   BH634808   BI232367   BI232886   BI351986   BI352812   BI483842   BI484995   BI616905   BI635589   BI635915   BI640233   CO310776   CO312768   DN154098   EC053812   EC213826   EC227076   EV577128   GH739359   GH740708   GH741076   GH743718   GH744094   GH745141   GH745356   GH746734   GH747257   GH762089   GH763302   GH764801   GH767571   GH769151   GH769541   GH769574
UniProtKB/Swiss-Prot	Q9VAN6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
pcr Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Sullivan et al., 2001) pre-blastoderm stage   organism   (Sullivan et al., 2001) embryonic stage 5 -- 12   organism | ubiquitous   (Sullivan et al., 2001) embryonic stage 11 -- 17   presumptive embryonic/larval peripheral nervous system   (Sullivan et al., 2001) presumptive embryonic/larval central nervous system   (Sullivan et al., 2001) embryonic stage 13 -- 17   embryonic/larval midgut primordium   (Sullivan et al., 2001)
Additional Descriptive Data
	Slbp transcript is detected in all developmental stages, with highest amounts in 0-8 hr embryos and adult females. Maternal Slbp transcript disappears by the end of the syncytial blastoderm stage. Ubiquitous zygotic expression begins at the cellular blastoderm stage, and is maintained during early germ-band extension. At later stages, expression decreases in G1 arrested cells and is restricted to proliferating and endoreduplicating cells. (Sullivan et al., 2001)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041186    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041186 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041186 expression level Developmental Stage   Expression Level embryo 00-02hr    10322 embryo 02-04hr    12112 embryo 04-06hr    18975 embryo 06-08hr    10199 embryo 08-10hr    4902 embryo 10-12hr    2690 embryo 12-14hr    1195 embryo 14-16hr    882 embryo 16-18hr    700 embryo 18-20hr    644 embryo 20-22hr    591 embryo 22-24hr    608 larva L1    1397 larva L2    1016 larva L3 12hr old    670 larva L3 puffstage 1-2    912 larva L3 puffstage 3-6    1180 larva L3 puffstage 7-9    1315 white prepupae new    1022 white prepupae 12hr    1581 white prepupae 24hr    1477 pupae 2d postWPP    1077 pupae 3d postWPP    844 pupae 4d postWPP    1020 adult male 01day    1393 adult male 05day    1895 adult male 30day    1710 adult female 01day    2567 adult female 05day    4962 adult female 30day    5861 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10322) embryo 02-04hr  (12112) embryo 04-06hr  (18975) embryo 06-08hr  (10199) embryo 08-10hr  (4902) embryo 10-12hr  (2690) embryo 12-14hr  (1195) embryo 14-16hr  (882) embryo 16-18hr  (700) embryo 18-20hr  (644) embryo 20-22hr  (591) embryo 22-24hr  (608) larva L1  (1397) larva L2  (1016) larva L3 12hr old  (670) larva L3 puffstage 1-2  (912) larva L3 puffstage 3-6  (1180) larva L3 puffstage 7-9  (1315) white prepupae new  (1022) white prepupae 12hr  (1581) white prepupae 24hr  (1477) pupae 2d postWPP  (1077) pupae 3d postWPP  (844) pupae 4d postWPP  (1020) adult male 01day  (1393) adult male 05day  (1895) adult male 30day  (1710) adult female 01day  (2567) adult female 05day  (4962) adult female 30day  (5861) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10322) embryo 02-04hr  (12112) embryo 04-06hr  (18975) embryo 06-08hr  (10199) embryo 08-10hr  (4902) embryo 10-12hr  (2690) embryo 12-14hr    1195 embryo 14-16hr    882 embryo 16-18hr    700 embryo 18-20hr    644 embryo 20-22hr    591 embryo 22-24hr    608 larva L1    1397 larva L2    1016 larva L3 12hr old    670 larva L3 puffstage 1-2    912 larva L3 puffstage 3-6    1180 larva L3 puffstage 7-9    1315 white prepupae new    1022 white prepupae 12hr  (1581) white prepupae 24hr  1477 pupae 2d postWPP    1077 pupae 3d postWPP    844 pupae 4d postWPP    1020 adult male 01day    1393 adult male 05day  (1895) adult male 30day  (1710) adult female 01day  (2567) adult female 05day  (4962) adult female 30day  (5861) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10322 embryo 02-04hr  (12112) embryo 04-06hr  (18975) embryo 06-08hr  10199 embryo 08-10hr    4902 embryo 10-12hr    2690 embryo 12-14hr    1195 embryo 14-16hr    882 embryo 16-18hr    700 embryo 18-20hr    644 embryo 20-22hr    591 embryo 22-24hr    608 larva L1    1397 larva L2    1016 larva L3 12hr old    670 larva L3 puffstage 1-2    912 larva L3 puffstage 3-6    1180 larva L3 puffstage 7-9    1315 white prepupae new    1022 white prepupae 12hr    1581 white prepupae 24hr    1477 pupae 2d postWPP    1077 pupae 3d postWPP    844 pupae 4d postWPP    1020 adult male 01day    1393 adult male 05day    1895 adult male 30day    1710 adult female 01day    2567 adult female 05day    4962 adult female 30day    5861 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10322 embryo 02-04hr    12112 embryo 04-06hr    18975 embryo 06-08hr    10199 embryo 08-10hr    4902 embryo 10-12hr    2690 embryo 12-14hr    1195 embryo 14-16hr    882 embryo 16-18hr    700 embryo 18-20hr    644 embryo 20-22hr    591 embryo 22-24hr    608 larva L1    1397 larva L2    1016 larva L3 12hr old    670 larva L3 puffstage 1-2    912 larva L3 puffstage 3-6    1180 larva L3 puffstage 7-9    1315 white prepupae new    1022 white prepupae 12hr    1581 white prepupae 24hr    1477 pupae 2d postWPP    1077 pupae 3d postWPP    844 pupae 4d postWPP    1020 adult male 01day    1393 adult male 05day    1895 adult male 30day    1710 adult female 01day    2567 adult female 05day    4962 adult female 30day    5861 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041186 expression level Developmental Stage   Expression Level embryo 00-02hr    10322 embryo 02-04hr    12112 embryo 04-06hr    18975 embryo 06-08hr    10199 embryo 08-10hr    4902 embryo 10-12hr    2690 embryo 12-14hr    1195 embryo 14-16hr    882 embryo 16-18hr    700 embryo 18-20hr    644 embryo 20-22hr    591 embryo 22-24hr    608 larva L1    1397 larva L2    1016 larva L3 12hr old    670 larva L3 puffstage 1-2    912 larva L3 puffstage 3-6    1180 larva L3 puffstage 7-9    1315 white prepupae new    1022 white prepupae 12hr    1581 white prepupae 24hr    1477 pupae 2d postWPP    1077 pupae 3d postWPP    844 pupae 4d postWPP    1020 adult male 01day    1393 adult male 05day    1895 adult male 30day    1710 adult female 01day    2567 adult female 05day    4962 adult female 30day    5861 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10322) embryo 02-04hr  (12112) embryo 04-06hr  (18975) embryo 06-08hr  (10199) embryo 08-10hr  (4902) embryo 10-12hr  (2690) embryo 12-14hr  (1195) embryo 14-16hr  (882) embryo 16-18hr  (700) embryo 18-20hr  (644) embryo 20-22hr  (591) embryo 22-24hr  (608) larva L1  (1397) larva L2  (1016) larva L3 12hr old  (670) larva L3 puffstage 1-2  (912) larva L3 puffstage 3-6  (1180) larva L3 puffstage 7-9  (1315) white prepupae new  (1022) white prepupae 12hr  (1581) white prepupae 24hr  (1477) pupae 2d postWPP  (1077) pupae 3d postWPP  (844) pupae 4d postWPP  (1020) adult male 01day  (1393) adult male 05day  (1895) adult male 30day  (1710) adult female 01day  (2567) adult female 05day  (4962) adult female 30day  (5861) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10322) embryo 02-04hr  (12112) embryo 04-06hr  (18975) embryo 06-08hr  (10199) embryo 08-10hr  (4902) embryo 10-12hr  (2690) embryo 12-14hr    1195 embryo 14-16hr    882 embryo 16-18hr    700 embryo 18-20hr    644 embryo 20-22hr    591 embryo 22-24hr    608 larva L1    1397 larva L2    1016 larva L3 12hr old    670 larva L3 puffstage 1-2    912 larva L3 puffstage 3-6    1180 larva L3 puffstage 7-9    1315 white prepupae new    1022 white prepupae 12hr  1581 white prepupae 24hr  1477 pupae 2d postWPP    1077 pupae 3d postWPP    844 pupae 4d postWPP    1020 adult male 01day    1393 adult male 05day  1895 adult male 30day  1710 adult female 01day  (2567) adult female 05day  (4962) adult female 30day  (5861) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10322 embryo 02-04hr  12112 embryo 04-06hr  18975 embryo 06-08hr  10199 embryo 08-10hr    4902 embryo 10-12hr    2690 embryo 12-14hr    1195 embryo 14-16hr    882 embryo 16-18hr    700 embryo 18-20hr    644 embryo 20-22hr    591 embryo 22-24hr    608 larva L1    1397 larva L2    1016 larva L3 12hr old    670 larva L3 puffstage 1-2    912 larva L3 puffstage 3-6    1180 larva L3 puffstage 7-9    1315 white prepupae new    1022 white prepupae 12hr    1581 white prepupae 24hr    1477 pupae 2d postWPP    1077 pupae 3d postWPP    844 pupae 4d postWPP    1020 adult male 01day    1393 adult male 05day    1895 adult male 30day    1710 adult female 01day    2567 adult female 05day    4962 adult female 30day    5861 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10322 embryo 02-04hr    12112 embryo 04-06hr    18975 embryo 06-08hr    10199 embryo 08-10hr    4902 embryo 10-12hr    2690 embryo 12-14hr    1195 embryo 14-16hr    882 embryo 16-18hr    700 embryo 18-20hr    644 embryo 20-22hr    591 embryo 22-24hr    608 larva L1    1397 larva L2    1016 larva L3 12hr old    670 larva L3 puffstage 1-2    912 larva L3 puffstage 3-6    1180 larva L3 puffstage 7-9    1315 white prepupae new    1022 white prepupae 12hr    1581 white prepupae 24hr    1477 pupae 2d postWPP    1077 pupae 3d postWPP    844 pupae 4d postWPP    1020 adult male 01day    1393 adult male 05day    1895 adult male 30day    1710 adult female 01day    2567 adult female 05day    4962 adult female 30day    5861 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041186    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041186 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval salivary gland, larval trachea, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041186 expression level Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary  (655.2) Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041186 expression level Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary  655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    304.425 Larval Midgut    42.1 Larval Hindgut    65.4 Larval Malpighian Tubules    39.1 Larval Fat Body    57.4 Larval Salivary Gland    149.2 Larval Trachea    147.45 Larval Carcass    94.25 Adult Head    79.2 Adult Eye    77.275 Adult Brain    132.9 Adult Thoracic-Abdominal Ganglion    107.3 Adult Crop    105.8 Adult Midgut    51.7 Adult Hindgut    57 Adult Malpighian Tubules    30.3 Adult Fat Body    82.3 Adult Salivary Gland    94.8 Adult Heart    66.45 Adult VirginFemale Spermatheca    37 Adult InseminatedFemale Spermatheca    43.7 Adult Ovary    655.2 Adult Testis    215 Adult Male Accessory Gland    71.9 Adult Carcass    84.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    79.2   NA  Eye    77.275   NA  Brain    132.9   304.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    107.3   NA  Crop    105.8   42.1  Midgut    51.7   65.4  Hindgut    57   39.1  Malpighian Tubules    30.3   57.4  Fat Body    82.3   149.2  Salivary Gland    94.8   NA  Heart    66.45   147.45  Trachea    NA   NA  VirginFemale Spermatheca    37   NA  InseminatedFemale Spermatheca    43.7   NA  Ovary    655.2   NA  Testis    215   NA  Male Accessory Gland    71.9   94.25  Carcass    84.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041186 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11886-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Slbp Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Slbp12 Slbp15 lethal | maternal effect Slbp10 lethal | pupal stage Slbp15 lethal | recessive Slbp35 Slbp47 semi-lethal Slbp19 semi-lethal (with Slbp10) Slbp12 Slbp15 semi-lethal (with Slbp12) Slbp10 semi-lethal (with Slbp15) Slbp10 semi-viable Slbp10 viable, with Scer\GAL4[-]: SlbpEP1045 SlbpEP3182 viable, with Scer\GAL4pnr-MD237 SlbpGD7420 Sterility Allele female sterile Slbp10 Slbp19 female sterile (with Df(3R)3450) Slbp10 male fertile Slbp10 Slbp19 male fertile (with Df(3R)3450) Slbp10 Other Phenotypes Allele wild-type Slbp+tSa Phenotype manifest in Allele mitotic cell cycle Slbp10 nuclear chromosome Slbp10
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Slbp Class Mutagen Stocks Known lesion Slbp10 P-element activity 1 Yes Slbp15 loss of function allele P-element activity 1 Yes SlbpEP1045 P-element activity 1 Yes SlbpHP36916 1 -- SlbpUM-8085-3 1 -- SlbpUM-8128-3 1 -- Slbp12 P-element activity 0 Yes Slbp19 P-element activity 0 Yes Slbp35 P-element activity 0 -- Slbp47 P-element activity 0 -- SlbpEP3182 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Slbp Class Mutagen Stocks Known lesion SlbpGD7420 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes SlbpKK108617 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Slbp+tSa in vitro construct - genomic fragment 0 Yes SlbpT120A.T230A.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes SlbpT120A.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes SlbpT230A.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes SlbpWT.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)3450 (Sullivan et al., 2001) Df(3R)Slbp12 (Sullivan et al., 2001) Df(3R)stgAR2 (Lanzotti et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7420} NA P{KK108617} NA characterization construct P{Slbp.HA} NA P{Slbp.T120A.HA} NA P{Slbp.T120A.T230A.HA} NA P{Slbp.T230A.HA} NA P{Slbp+tSa} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}SlbpEP1045 NA P{EP}SlbpEP3182 NA P{EPg}SlbpHP36916 NA miscellaneous insertions P{EP-Δ10}Slbp10 NA P{EP-Δ15}Slbp15 NA P{EP-Δ19}Slbp19 NA P{RS3}SlbpUM-8085-3 NA P{RS3}SlbpUM-8128-3 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from mutant phenotype (Duronio et al., 2000) RNA stem-loop binding inferred from direct assay (Borchers et al., 2006)
Biological Process
CV term Evidence References
cell cycle inferred from mutant phenotype (Sullivan et al., 2001) histone mRNA 3'-end processing inferred from direct assay (Dominski et al., 2002) inferred from mutant phenotype (Sullivan et al., 2001, Lanzotti et al., 2004, Wagner et al., 2007, Godfrey et al., 2006, Sullivan et al., 2009) histone mRNA metabolic process inferred from mutant phenotype (Duronio et al., 2000)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Lanzotti et al., 2004) nucleus inferred from direct assay (Lanzotti et al., 2004)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mRNA binding non-traceable author statement (Sullivan, 2000.4.19)
Biological Process
CV term Evidence References
cell cycle non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) histone mRNA 3'-end processing non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Slbp allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041186 DroID - A comprehensive database of gene and protein interactions. • FBgn0041186 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43448
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18411 Dere\GG12032 Dgri\GH14009 Dmoj\GI22353 Dper\GL23600 Dpse\GA11260 Dsec\GM12257 Dsim\GD15074 Dvir\GJ14235 Dwil\GK22497 Dyak\GE10470
Curated drosophilid orthologs	Dpse\GA11260
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010422-PA Aedes aegypti (mosquito) 126853 Branchiostoma floridae (lancelet) XP_001898525.1 Brugia malayi (roundworm nematode) ENSBTAP00000001753 Bos taurus (bovine) CN05370 Caenorhabditis brenneri (small nematode) CBP14493 Caenorhabditis briggsae (nematode) CE01616 Caenorhabditis elegans (worm) ENSCAFP00000022121 Canis familiaris (dog) Chro.60191 Cryptosporidium hominis (obligate parasite) JA04007 Caenorhabditis japonica (nematode) cgd6_1540 Cryptosporidium parvum (protozoan parasite) CPIJ008644 Culex pipens (mosquito) ENSCPOP00000000027 Cavia porcellus (guinea pig) RP07079 Caenorhabditis remanei (nematode) 219525 Capitella spl (polychaete worm) ENSDARP00000018681 Danio rerio (zebra fish) ENSECAP00000009611 Equus caballus (horse) XP_657327 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000025905 Gymnopilus aculeatus (mushroom) ENSP00000316490 Homo sapiens (human) ISCW022471-PA Ixodes scapularis (deer tick) ENSMODP00000005298 Monodelphis domestica (gray opossum) ENSMUSP00000062930 Mus musculus (house mouse) PFI1355w Plasmodium falciparum (protozoal parasite) PP02004 Pristionchus pacificus (nematode) 170461 Physcomitrella patens (moss) ENSPPYP00000016236 Pongo pygmaeus (orangutan) ENSPTRP00000027262 Pan troglodytes (chimpanzee) ENSTRUP00000001645 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000008408 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12650 LH18156 ISCW022471 FBgn0228331 FBgn0224475 FBgn0224474 FBgn0201450 FBgn0186746 FBgn0167194 JGI_V11_45102 FBgn0071314 FBgn0161190 FBgn0145081 FBgn0130682 FBgn0130680 FBgn0121485 FBgn0104324 FBgn0095429 CPIJ008644 BGIBMGA005486 ACYPI001641 GB13630 AGAP013023 AGAP012972 AAEL010422 PB25271 PHUM317680 GLEAN_12536
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	17211 w1118; P{EP}SlbpEP1045/TM6B, Tb1 22127 w1118; P{EPg}SlbpHP36916/TM3, Ser1 34056 w*; Slbp10/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb1 Ser1 34057 w*; Slbp15/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb1 Ser1
Kyoto	124329 w1118; P{RS3}SlbpUM-8085-3 124360 w1118; P{RS3}SlbpUM-8128-3
VDRC	v100785 P{KK108617}VIE-260B v42970 w1118; P{GD7420}v42970 v42971 w1118; P{GD7420}v42971 v48746 w1118; P{GD7420}v48746
Genomic Clones ( 1 )
	BACR22E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM06606 RH47057
Other clones	DPiM_GM06606
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05738 GM02081 GM03444 GM05877 GM17123 GM20909 RE28422 RE29034 RE66792 RE68208 SD16979 SD17452 SD23044
Other clones	104851 164932 Dmel_dig_002399_0705_2273 EC053812 EK176828 EK222507 EK229941 RP001003678 RP001005766 RP001007162 RP001016340 RP001023644 RP001024841 RP001029521 RP001031776 RP001037765 RP001038086 RP001039142 RP001041465 RP001043833 RP001050363 RP001050402 RP001050923
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041186 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43448
Antibody Information
	polyclonal (Sullivan et al., 2001, Sullivan et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Slbp CG11886 (FlyBase, 1996-)
Additional comments	Source for merge of Slbp CG11886 was sequence comparison (date:000526). (FlyBase, 1996-)
Other Comments
	Mutant analysis shows that phosphorylation of Slbp at T230 is necessary for its localization to the cytoplasm and subsequent function in the 3'-end processing of histone mRNA. (Lanzotti et al., 2004) Slbp is required for 3' end processing of histone pre-mRNA. Overall orientation not stated: Pglym78+ ligatin- Slbp- Rpn2+ (Sullivan et al., 2001) Slbp-dependant processing plays an important role in coupling histone mRNA production with the cell cycle. (Sullivan et al., 2001) The pattern of histone mRNA accumulation is disrupted in mutant embryos. (Duronio et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058132 RefSeq (Proteins) • NP_477480 DDBJ / EMBL / GenBank • AA802944 AAF56867 AAF71752 AAG16723 AAL90413 AAM50696 AC007855 AF186594 AF258617 AQ025158 AQ073799 AY089675 AY118836 BH634808 BI616905 Entrez Gene - A searchable database of RefSeq genes. • 43448 UniProtKB/Swiss-Prot • Q9VAN6
Other Crossreferences
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041186 DroID - A comprehensive database of gene and protein interactions. • FBgn0041186 DRSC - Results from RNAi screens. • FBgn0041186 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041186 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11886-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041186 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43448 InParanoid A subset of ortholog calls from InParanoid. • AAEL010422-PA Aedes aegypti (mosquito) 126853 Branchiostoma floridae (lancelet) XP_001898525.1 Brugia malayi (roundworm nematode) ENSBTAP00000001753 Bos taurus (bovine) CN05370 Caenorhabditis brenneri (small nematode) CBP14493 Caenorhabditis briggsae (nematode) CE01616 Caenorhabditis elegans (worm) ENSCAFP00000022121 Canis familiaris (dog) Chro.60191 Cryptosporidium hominis (obligate parasite) JA04007 Caenorhabditis japonica (nematode) cgd6_1540 Cryptosporidium parvum (protozoan parasite) CPIJ008644 Culex pipens (mosquito) ENSCPOP00000000027 Cavia porcellus (guinea pig) RP07079 Caenorhabditis remanei (nematode) 219525 Capitella spl (polychaete worm) ENSDARP00000018681 Danio rerio (zebra fish) ENSECAP00000009611 Equus caballus (horse) XP_657327 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000025905 Gymnopilus aculeatus (mushroom) ENSP00000316490 Homo sapiens (human) ISCW022471-PA Ixodes scapularis (deer tick) ENSMODP00000005298 Monodelphis domestica (gray opossum) ENSMUSP00000062930 Mus musculus (house mouse) PFI1355w Plasmodium falciparum (protozoal parasite) PP02004 Pristionchus pacificus (nematode) 170461 Physcomitrella patens (moss) ENSPPYP00000016236 Pongo pygmaeus (orangutan) ENSPTRP00000027262 Pan troglodytes (chimpanzee) ENSTRUP00000001645 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000008408 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43448 modMine - Data generated by the modENCODE project. • FBgn0041186 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12650 LH18156 ISCW022471 FBgn0228331 FBgn0224475 FBgn0224474 FBgn0201450 FBgn0186746 FBgn0167194 JGI_V11_45102 FBgn0071314 FBgn0161190 FBgn0145081 FBgn0130682 FBgn0130680 FBgn0121485 FBgn0104324 FBgn0095429 CPIJ008644 BGIBMGA005486 ACYPI001641 GB13630 AGAP013023 AGAP012972 AAEL010422 PB25271 PHUM317680 GLEAN_12536
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG11886 (Brody et al., 2002, Keleman et al., 2009.8.5) dSLBP (Robertson, 2004, Thapar et al., 2004, Thapar et al., 2004, Kupsco et al., 2004, Dominski et al., 2003, Duronio et al., 2000, Yang et al., 2009, Dominski et al., 2002, Lanzotti et al., 2002, Borchers et al., 2006) dSLPB (Sullivan et al., 2001) SLBP (Godfrey et al., 2005, Wagner et al., 2007, White et al., 2011, Ezzeddine et al., 2011, Tatomer et al., 2008, Wagner et al., 2008, Sullivan et al., 2009, Dominski et al., 2005, Godfrey et al., 2006, Kupsco et al., 2006) slbp (Orian et al., 2003) Slbp (Lafave and Sekelsky, 2011, Wagner et al., 2007, White et al., 2007, Salzler et al., 2009, Bulchand et al., 2010)
Name Synonym	Stem-loop binding protein (Duronio et al., 2000, Bulchand et al., 2010) stem-loop binding protein (Dominski et al., 2002, Tadros et al., 2007) stem loop binding protein (Wagner et al., 2007) Stem-Loop Binding Protein (Salzler et al., 2009)
Secondary FlyBase IDs
	FBgn0039643
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Conference report  ( 1 )
Recent research papers ( 4 )
	Ezzeddine et al., 2011, Mol. Cell. Biol. 31(2): 328--341 A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation. [FBrf0212592] Lafave and Sekelsky, 2011, Genetics 188(3): 749--752 Transcription Initiation From Within P Elements Generates Hypomorphic Mutations in Drosophila melanogaster. [FBrf0214251] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Bulchand et al., 2010, J. Cell Sci. 123(16): 2697--2707 Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. [FBrf0211459] Show all research papers ...