dAtx2, l(3)06490, Atx-2, dSCA2, ATXN2
multi-functional protein that binds DEAD box helicases of the Me31B family that associated with Argonaute and microRNA function - required for microRNA function and synapse-specific long-term olfactory habituation - assembles with polyribosomes and poly(A)-binding protein, a key regulator of mRNA translation
Please see the JBrowse view of Dmel\Atx2 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
Homodimer (PubMed:28388438). In the circadian pacemaker neurons, core component of the Atx2-tyf activator complex composed of at least Atx2, tyf, pAbp, Lsm12a (PubMed:28388438). In the circadian pacemaker neurons, also a core component of the Atx2-Not1 repressor complex composed of at least Atx2, tyf, pAbp, me31B (PubMed:28388438). Interacts (via PAM2 motif) with pAbp (PubMed:28388438). Interacts (via N-terminus) with tyf independently of pAbp (PubMed:28388438). Forms a subcomplex composed of Atx2 and pAbP which can associate with the 5' cap of pre-mRNAs independently of tyf, Lsm12a or me31B (PubMed:28388438). Interacts with Lsm12a and me31B (PubMed:28388438).
The PAM2 motif, and therefore interaction with pAbp, is essential for binding to the 5' cap of pre-mRNAs.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atx2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
An antibody directed against the N-terminal part of Atx2-PB detects protein at all stages confirming that the upstream ATG is used. Levels are significantly higher in embryos and first instar larvae than in second instar larvae, third instar larvae, pupae, and adults. An antibody that detects both forms detects similar levels at all stages. Atx2 protein levels are higher in extracts from ovaries than in imaginal disc, CNS, fat body, or testis extracts.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Atx2 in JBrowse3-57
3-56.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Area matching Drosophila EST AI062939.
Source for merge of: Atx2 l(3)06490 BEST:GH27029
Source for merge of: Atx2 CG5166
Source for merge of: Atx2 anon-WO0118547.351 anon-WO0140519.1
Source for merge of: Atx2 anon- EST:fe2E1
Source for merge of Atx2 CG5166 was a shared cDNA ( date:030206 ).
Source for merge of Atx2 anon-WO0118547.351 anon-WO0140519.1 was sequence comparison ( date:051113 ).
Source for merge of Atx2 anon- EST:fe2E1 was sequence comparison ( date:030620 ).