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Gene Dmel\Rheb

General Information
Symbol	Dmel\Rheb	Species	D. melanogaster
Name	Rheb	Annotation symbol	CG1081
Feature type	protein_coding_gene	FlyBase ID	FBgn0041191
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	dRheb
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83B2-83B2	Sequence location	3R:1,394,618..1,396,213 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rheb is referred to in FlyBase by the symbol Dmel\Rheb (CG1081, FBgn0041191). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GTPase activity. There is experimental evidence that it is involved in the biological process: response to starvation; regulation of reactive oxygen species metabolic process; positive regulation of cell size; ribosome biogenesis; positive regulation of translation; cell growth; G1/S transition of mitotic cell cycle; positive regulation of ribosome biogenesis; imaginal disc growth. 33 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; cell cycle; adult segment; external compound sense organ; cellular process; cell cycle process; multicellular structure; nuclear part; thoracic segment; adult; synapse; imaginal precursor. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Ras type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult midgut, larval/adult Malpighian tubules, adult heart, adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval/adult hindgut, larval/adult fat body, larval salivary gland, adult ovary, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630949_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Rheb. Gene sequence location is 3R:1394618..1396213.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Dekanty et al., 2010, PLoS Genet. 6(6): e1000994 Hsieh et al., 2010, PLoS Genet. 6(8): Sequence features HFA12148 BKN28469
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83B2-83B2   Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rheb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rheb-RA FBtr0078693  NM_169068   1250   182 Rheb-RB FBtr0078694  NM_169069   1021   182
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rheb-PA   FBpp0078342   20.7   182   5.32     NP_730950   AAF52004 Rheb-PB   FBpp0078343   20.7   182   5.32     NP_730951   AAF52005
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTP-binding protein domain (IPR005225) Small GTPase superfamily, Ras type (IPR020849)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA736136   AA803773   AA951113   AE014297 AAF52004   AE014297 AAF52005   AI062407   AI113871   AI238559   AI238640   AI238984   AI257458   AI260251   AI260339   AI292970   AI293491   AI295179   AI297693   AI518993   AW940360   AY094697 AAM11050   BG636603   BI164772   BI229935   BI235248   BI368197   BI370034   BI372670   BI579949   BI632415   BI638966   BP541839   BP548838   BP548839   CL528079   CO178530   CO181530   CO182337   CO265754   CO272344   CO272582   CO299999   CO300205   CO301593   CO306622   CO318381   CO324460   CO337870   CZ467743   DU708690   EC063337   EC064165   EC071831   EC074164   EC078269   EC084325   EC203071   EC209245   EC211377   EC218608   EC265269   EL881745   EL881746   EL883922   EV581541   EV582101   EV585056   EV596291   FE863454   FE863476   FE863548   FE863748   FE863798   FE863935   GH739308   GH739694   GH739790   GH739883   GH739897   GH740649   GH745045   GH746807   GH747135   GH763784   GH764390   GH765091   GH766167   GH766259   GH767795   GH768619   GH768870   GH769700
UniProtKB/Swiss-Prot	Q9VND8
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041191    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041191 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041191 expression level Developmental Stage   Expression Level embryo 00-02hr    4609 embryo 02-04hr    3572 embryo 04-06hr    2641 embryo 06-08hr    3194 embryo 08-10hr    3898 embryo 10-12hr    5059 embryo 12-14hr    4718 embryo 14-16hr    3180 embryo 16-18hr    3655 embryo 18-20hr    4170 embryo 20-22hr    3731 embryo 22-24hr    5411 larva L1    3516 larva L2    2992 larva L3 12hr old    2744 larva L3 puffstage 1-2    4142 larva L3 puffstage 3-6    4459 larva L3 puffstage 7-9    5088 white prepupae new    4070 white prepupae 12hr    3616 white prepupae 24hr    3901 pupae 2d postWPP    3922 pupae 3d postWPP    3279 pupae 4d postWPP    1662 adult male 01day    3379 adult male 05day    4007 adult male 30day    3338 adult female 01day    3004 adult female 05day    4408 adult female 30day    4067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4609) embryo 02-04hr  (3572) embryo 04-06hr  (2641) embryo 06-08hr  (3194) embryo 08-10hr  (3898) embryo 10-12hr  (5059) embryo 12-14hr  (4718) embryo 14-16hr  (3180) embryo 16-18hr  (3655) embryo 18-20hr  (4170) embryo 20-22hr  (3731) embryo 22-24hr  (5411) larva L1  (3516) larva L2  (2992) larva L3 12hr old  (2744) larva L3 puffstage 1-2  (4142) larva L3 puffstage 3-6  (4459) larva L3 puffstage 7-9  (5088) white prepupae new  (4070) white prepupae 12hr  (3616) white prepupae 24hr  (3901) pupae 2d postWPP  (3922) pupae 3d postWPP  (3279) pupae 4d postWPP  (1662) adult male 01day  (3379) adult male 05day  (4007) adult male 30day  (3338) adult female 01day  (3004) adult female 05day  (4408) adult female 30day  (4067) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4609) embryo 02-04hr  (3572) embryo 04-06hr  (2641) embryo 06-08hr  (3194) embryo 08-10hr  (3898) embryo 10-12hr  (5059) embryo 12-14hr  (4718) embryo 14-16hr  (3180) embryo 16-18hr  (3655) embryo 18-20hr  (4170) embryo 20-22hr  (3731) embryo 22-24hr  (5411) larva L1  (3516) larva L2  (2992) larva L3 12hr old  (2744) larva L3 puffstage 1-2  (4142) larva L3 puffstage 3-6  (4459) larva L3 puffstage 7-9  (5088) white prepupae new  (4070) white prepupae 12hr  (3616) white prepupae 24hr  (3901) pupae 2d postWPP  (3922) pupae 3d postWPP  (3279) pupae 4d postWPP  (1662) adult male 01day  (3379) adult male 05day  (4007) adult male 30day  (3338) adult female 01day  (3004) adult female 05day  (4408) adult female 30day  (4067) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4609 embryo 02-04hr    3572 embryo 04-06hr    2641 embryo 06-08hr    3194 embryo 08-10hr    3898 embryo 10-12hr    5059 embryo 12-14hr    4718 embryo 14-16hr    3180 embryo 16-18hr    3655 embryo 18-20hr    4170 embryo 20-22hr    3731 embryo 22-24hr    5411 larva L1    3516 larva L2    2992 larva L3 12hr old    2744 larva L3 puffstage 1-2    4142 larva L3 puffstage 3-6    4459 larva L3 puffstage 7-9    5088 white prepupae new    4070 white prepupae 12hr    3616 white prepupae 24hr    3901 pupae 2d postWPP    3922 pupae 3d postWPP    3279 pupae 4d postWPP    1662 adult male 01day    3379 adult male 05day    4007 adult male 30day    3338 adult female 01day    3004 adult female 05day    4408 adult female 30day    4067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4609 embryo 02-04hr    3572 embryo 04-06hr    2641 embryo 06-08hr    3194 embryo 08-10hr    3898 embryo 10-12hr    5059 embryo 12-14hr    4718 embryo 14-16hr    3180 embryo 16-18hr    3655 embryo 18-20hr    4170 embryo 20-22hr    3731 embryo 22-24hr    5411 larva L1    3516 larva L2    2992 larva L3 12hr old    2744 larva L3 puffstage 1-2    4142 larva L3 puffstage 3-6    4459 larva L3 puffstage 7-9    5088 white prepupae new    4070 white prepupae 12hr    3616 white prepupae 24hr    3901 pupae 2d postWPP    3922 pupae 3d postWPP    3279 pupae 4d postWPP    1662 adult male 01day    3379 adult male 05day    4007 adult male 30day    3338 adult female 01day    3004 adult female 05day    4408 adult female 30day    4067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041191 expression level Developmental Stage   Expression Level embryo 00-02hr    4609 embryo 02-04hr    3572 embryo 04-06hr    2641 embryo 06-08hr    3194 embryo 08-10hr    3898 embryo 10-12hr    5059 embryo 12-14hr    4718 embryo 14-16hr    3180 embryo 16-18hr    3655 embryo 18-20hr    4170 embryo 20-22hr    3731 embryo 22-24hr    5411 larva L1    3516 larva L2    2992 larva L3 12hr old    2744 larva L3 puffstage 1-2    4142 larva L3 puffstage 3-6    4459 larva L3 puffstage 7-9    5088 white prepupae new    4070 white prepupae 12hr    3616 white prepupae 24hr    3901 pupae 2d postWPP    3922 pupae 3d postWPP    3279 pupae 4d postWPP    1662 adult male 01day    3379 adult male 05day    4007 adult male 30day    3338 adult female 01day    3004 adult female 05day    4408 adult female 30day    4067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4609) embryo 02-04hr  (3572) embryo 04-06hr  (2641) embryo 06-08hr  (3194) embryo 08-10hr  (3898) embryo 10-12hr  (5059) embryo 12-14hr  (4718) embryo 14-16hr  (3180) embryo 16-18hr  (3655) embryo 18-20hr  (4170) embryo 20-22hr  (3731) embryo 22-24hr  (5411) larva L1  (3516) larva L2  (2992) larva L3 12hr old  (2744) larva L3 puffstage 1-2  (4142) larva L3 puffstage 3-6  (4459) larva L3 puffstage 7-9  (5088) white prepupae new  (4070) white prepupae 12hr  (3616) white prepupae 24hr  (3901) pupae 2d postWPP  (3922) pupae 3d postWPP  (3279) pupae 4d postWPP  (1662) adult male 01day  (3379) adult male 05day  (4007) adult male 30day  (3338) adult female 01day  (3004) adult female 05day  (4408) adult female 30day  (4067) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4609) embryo 02-04hr  (3572) embryo 04-06hr  (2641) embryo 06-08hr  (3194) embryo 08-10hr  (3898) embryo 10-12hr  (5059) embryo 12-14hr  (4718) embryo 14-16hr  (3180) embryo 16-18hr  (3655) embryo 18-20hr  (4170) embryo 20-22hr  (3731) embryo 22-24hr  (5411) larva L1  (3516) larva L2  (2992) larva L3 12hr old  (2744) larva L3 puffstage 1-2  (4142) larva L3 puffstage 3-6  (4459) larva L3 puffstage 7-9  (5088) white prepupae new  (4070) white prepupae 12hr  (3616) white prepupae 24hr  (3901) pupae 2d postWPP  (3922) pupae 3d postWPP  (3279) pupae 4d postWPP  1662 adult male 01day  (3379) adult male 05day  (4007) adult male 30day  (3338) adult female 01day  (3004) adult female 05day  (4408) adult female 30day  (4067) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4609 embryo 02-04hr    3572 embryo 04-06hr    2641 embryo 06-08hr    3194 embryo 08-10hr    3898 embryo 10-12hr    5059 embryo 12-14hr    4718 embryo 14-16hr    3180 embryo 16-18hr    3655 embryo 18-20hr    4170 embryo 20-22hr    3731 embryo 22-24hr    5411 larva L1    3516 larva L2    2992 larva L3 12hr old    2744 larva L3 puffstage 1-2    4142 larva L3 puffstage 3-6    4459 larva L3 puffstage 7-9    5088 white prepupae new    4070 white prepupae 12hr    3616 white prepupae 24hr    3901 pupae 2d postWPP    3922 pupae 3d postWPP    3279 pupae 4d postWPP    1662 adult male 01day    3379 adult male 05day    4007 adult male 30day    3338 adult female 01day    3004 adult female 05day    4408 adult female 30day    4067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4609 embryo 02-04hr    3572 embryo 04-06hr    2641 embryo 06-08hr    3194 embryo 08-10hr    3898 embryo 10-12hr    5059 embryo 12-14hr    4718 embryo 14-16hr    3180 embryo 16-18hr    3655 embryo 18-20hr    4170 embryo 20-22hr    3731 embryo 22-24hr    5411 larva L1    3516 larva L2    2992 larva L3 12hr old    2744 larva L3 puffstage 1-2    4142 larva L3 puffstage 3-6    4459 larva L3 puffstage 7-9    5088 white prepupae new    4070 white prepupae 12hr    3616 white prepupae 24hr    3901 pupae 2d postWPP    3922 pupae 3d postWPP    3279 pupae 4d postWPP    1662 adult male 01day    3379 adult male 05day    4007 adult male 30day    3338 adult female 01day    3004 adult female 05day    4408 adult female 30day    4067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041191    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041191 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult midgut, larval/adult Malpighian tubules, adult heart, adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval/adult hindgut, larval/adult fat body, larval salivary gland, adult ovary, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041191 expression level Tissue   Expression Level Larval Central Nervous System    351.85 Larval Midgut    353.2 Larval Hindgut    369.2 Larval Malpighian Tubules    603.8 Larval Fat Body    487.9 Larval Salivary Gland    379.1 Larval Trachea    607.525 Larval Carcass    335.175 Adult Head    559.6 Adult Eye    686.325 Adult Brain    386.5 Adult Thoracic-Abdominal Ganglion    430.5 Adult Crop    526.2 Adult Midgut    583 Adult Hindgut    358.8 Adult Malpighian Tubules    630.7 Adult Fat Body    469.2 Adult Salivary Gland    537.4 Adult Heart    796.35 Adult VirginFemale Spermatheca    963.2 Adult InseminatedFemale Spermatheca    940.9 Adult Ovary    377.6 Adult Testis    219.2 Adult Male Accessory Gland    767.2 Adult Carcass    499.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    351.85 Larval Midgut    353.2 Larval Hindgut    369.2 Larval Malpighian Tubules  (603.8) Larval Fat Body    487.9 Larval Salivary Gland    379.1 Larval Trachea  (607.525) Larval Carcass    335.175 Adult Head  (559.6) Adult Eye  (686.325) Adult Brain    386.5 Adult Thoracic-Abdominal Ganglion    430.5 Adult Crop  526.2 Adult Midgut  (583) Adult Hindgut    358.8 Adult Malpighian Tubules  (630.7) Adult Fat Body    469.2 Adult Salivary Gland  537.4 Adult Heart  (796.35) Adult VirginFemale Spermatheca  (963.2) Adult InseminatedFemale Spermatheca  (940.9) Adult Ovary    377.6 Adult Testis    219.2 Adult Male Accessory Gland  (767.2) Adult Carcass    499.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    351.85 Larval Midgut    353.2 Larval Hindgut    369.2 Larval Malpighian Tubules    603.8 Larval Fat Body    487.9 Larval Salivary Gland    379.1 Larval Trachea    607.525 Larval Carcass    335.175 Adult Head    559.6 Adult Eye    686.325 Adult Brain    386.5 Adult Thoracic-Abdominal Ganglion    430.5 Adult Crop    526.2 Adult Midgut    583 Adult Hindgut    358.8 Adult Malpighian Tubules    630.7 Adult Fat Body    469.2 Adult Salivary Gland    537.4 Adult Heart    796.35 Adult VirginFemale Spermatheca    963.2 Adult InseminatedFemale Spermatheca    940.9 Adult Ovary    377.6 Adult Testis    219.2 Adult Male Accessory Gland    767.2 Adult Carcass    499.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    351.85 Larval Midgut    353.2 Larval Hindgut    369.2 Larval Malpighian Tubules    603.8 Larval Fat Body    487.9 Larval Salivary Gland    379.1 Larval Trachea    607.525 Larval Carcass    335.175 Adult Head    559.6 Adult Eye    686.325 Adult Brain    386.5 Adult Thoracic-Abdominal Ganglion    430.5 Adult Crop    526.2 Adult Midgut    583 Adult Hindgut    358.8 Adult Malpighian Tubules    630.7 Adult Fat Body    469.2 Adult Salivary Gland    537.4 Adult Heart    796.35 Adult VirginFemale Spermatheca    963.2 Adult InseminatedFemale Spermatheca    940.9 Adult Ovary    377.6 Adult Testis    219.2 Adult Male Accessory Gland    767.2 Adult Carcass    499.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041191 expression level Tissue   Expression Level Larval Central Nervous System    351.85 Larval Midgut    353.2 Larval Hindgut    369.2 Larval Malpighian Tubules    603.8 Larval Fat Body    487.9 Larval Salivary Gland    379.1 Larval Trachea    607.525 Larval Carcass    335.175 Adult Head    559.6 Adult Eye    686.325 Adult Brain    386.5 Adult Thoracic-Abdominal Ganglion    430.5 Adult Crop    526.2 Adult Midgut    583 Adult Hindgut    358.8 Adult Malpighian Tubules    630.7 Adult Fat Body    469.2 Adult Salivary Gland    537.4 Adult Heart    796.35 Adult VirginFemale Spermatheca    963.2 Adult InseminatedFemale Spermatheca    940.9 Adult Ovary    377.6 Adult Testis    219.2 Adult Male Accessory Gland    767.2 Adult Carcass    499.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    351.85 Larval Midgut    353.2 Larval Hindgut    369.2 Larval Malpighian Tubules  603.8 Larval Fat Body    487.9 Larval Salivary Gland    379.1 Larval Trachea  607.525 Larval Carcass    335.175 Adult Head  559.6 Adult Eye  686.325 Adult Brain    386.5 Adult Thoracic-Abdominal Ganglion    430.5 Adult Crop  526.2 Adult Midgut  583 Adult Hindgut    358.8 Adult Malpighian Tubules  630.7 Adult Fat Body    469.2 Adult Salivary Gland  537.4 Adult Heart  796.35 Adult VirginFemale Spermatheca  (963.2) Adult InseminatedFemale Spermatheca  (940.9) Adult Ovary    377.6 Adult Testis    219.2 Adult Male Accessory Gland  767.2 Adult Carcass    499.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    351.85 Larval Midgut    353.2 Larval Hindgut    369.2 Larval Malpighian Tubules    603.8 Larval Fat Body    487.9 Larval Salivary Gland    379.1 Larval Trachea    607.525 Larval Carcass    335.175 Adult Head    559.6 Adult Eye    686.325 Adult Brain    386.5 Adult Thoracic-Abdominal Ganglion    430.5 Adult Crop    526.2 Adult Midgut    583 Adult Hindgut    358.8 Adult Malpighian Tubules    630.7 Adult Fat Body    469.2 Adult Salivary Gland    537.4 Adult Heart    796.35 Adult VirginFemale Spermatheca    963.2 Adult InseminatedFemale Spermatheca    940.9 Adult Ovary    377.6 Adult Testis    219.2 Adult Male Accessory Gland    767.2 Adult Carcass    499.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    351.85 Larval Midgut    353.2 Larval Hindgut    369.2 Larval Malpighian Tubules    603.8 Larval Fat Body    487.9 Larval Salivary Gland    379.1 Larval Trachea    607.525 Larval Carcass    335.175 Adult Head    559.6 Adult Eye    686.325 Adult Brain    386.5 Adult Thoracic-Abdominal Ganglion    430.5 Adult Crop    526.2 Adult Midgut    583 Adult Hindgut    358.8 Adult Malpighian Tubules    630.7 Adult Fat Body    469.2 Adult Salivary Gland    537.4 Adult Heart    796.35 Adult VirginFemale Spermatheca    963.2 Adult InseminatedFemale Spermatheca    940.9 Adult Ovary    377.6 Adult Testis    219.2 Adult Male Accessory Gland    767.2 Adult Carcass    499.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    559.6   NA  Eye    686.325   NA  Brain    386.5   351.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    430.5   NA  Crop    526.2   353.2  Midgut    583   369.2  Hindgut    358.8   603.8  Malpighian Tubules    630.7   487.9  Fat Body    469.2   379.1  Salivary Gland    537.4   NA  Heart    796.35   607.525  Trachea    NA   NA  VirginFemale Spermatheca    963.2   NA  InseminatedFemale Spermatheca    940.9   NA  Ovary    377.6   NA  Testis    219.2   NA  Male Accessory Gland    767.2   335.175  Carcass    499.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041191 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1081-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4byn-Gal4 RhebAV4 lethal | larval stage (with RhebPΔ1) RhebPΔ2 lethal | larval stage (with RhebPΔ2) RhebPΔ1 lethal | larval stage | recessive RhebAV4 lethal | pupal stage (with Rheb3M2) Rheb26.2 lethal | pupal stage (with Rheb7A1) Rheb26.2 lethal | pupal stage (with Rheb26.2) Rheb3M2 Rheb7A1 lethal | recessive RhebLA01053 lethal | recessive | second instar larval stage, with Scer\GAL4[-]: RhebAV4 semi-lethal | larval stage (with Rheb7A1) Rheb26.2 semi-lethal | larval stage (with Rheb26.2) Rheb7A1 viable (with Rheb2G5) Rheb44.1 viable (with Rheb3M2) Rheb44.1 viable (with Rheb7A1) Rheb44.1 viable (with Rheb44.1) Rheb2G5 Rheb3M2 Rheb7A1 Sterility Allele female sterile (with Rheb7A1) Rheb44.1 female sterile (with Rheb44.1) Rheb7A1 Other Phenotypes Allele cell death defective | somatic clone, with Scer\GAL4Scer\FRT.Rnor\CD2.Act5C RhebEP50.084-loxP cell size defective RhebAct5C.T:Zzzz\FLAG RhebdsRNA.cPa cell size defective, with Scer\GAL4ap-md544 RhebScer\UAS.cPa cell size defective | somatic clone, with Scer\GAL4[-]: RhebAV4 chemical sensitive, with Scer\GAL4P2.4.Pdf RhebScer\UAS.cPa decreased cell number | somatic clone Rheb2D1 decreased cell size | somatic clone Rheb2D1 Rheb3M2 Rheb26.2 developmental rate defective, with Scer\GAL4[-]: RhebAV4 developmental rate defective (with RhebPΔ1) RhebPΔ2 developmental rate defective (with RhebPΔ2) RhebPΔ1 eclosion rhythm defective | dominant | drug conditional, with Scer\GAL4[-]: RhebAV4 increased cell death, with Scer\GAL4GMR.PU RhebScer\UAS.cSa increased cell size RhebEP50.084-loxP increased cell size, with Scer\GAL4en-e16E RhebScer\UAS.cSa increased cell size, with Scer\GAL4GMR.PF RhebScer\UAS.cSa increased cell size | somatic clone, with Scer\GAL4Act5C.PP RhebEP50.084 RhebScer\UAS.cSa large body, with Scer\GAL4GMR.PF RhebEP50.084-loxP mitotic cell cycle defective, with Scer\GAL4Act5C.PP RhebScer\UAS.cSa neuroanatomy defective, with Scer\GAL4796 RhebEP50.084-loxP small body | adult stage (with Rheb2G5) Rheb44.1 small body | adult stage (with Rheb3M2) Rheb44.1 small body | adult stage (with Rheb7A1) Rheb44.1 small body | adult stage (with Rheb44.1) Rheb2G5 Rheb3M2 Rheb7A1 small body | first instar larval stage | recessive, with Scer\GAL4[-]: RhebAV4 small body | larval stage (with Rheb7A1) Rheb26.2 small body | larval stage (with Rheb26.2) Rheb7A1 small body | pupal stage (with Rheb7A1) Rheb26.2 small body | pupal stage (with Rheb26.2) Rheb7A1 visible, with Scer\GAL4GMR.PF RhebScer\UAS.cPa visible, with Scer\GAL4ptc-559.1 RhebScer\UAS.cSa Phenotype manifest in Allele 1st posterior cell, with Scer\GAL4ptc-559.1 RhebScer\UAS.cSa adult brain, with Scer\GAL4elav.PLu Rheb1.1.Scer\UAS antenna, with Scer\GAL4Act5C.PI RhebAV4 embryonic/larval hindgut, with Scer\GAL4byn-Gal4 RhebAV4 embryonic/larval neuroblast, with Scer\GAL4nab RhebScer\UAS.cUa embryonic/larval salivary gland (with Rheb3M2) Rheb26.2 embryonic/larval salivary gland (with Rheb26.2) Rheb3M2 eye, with Scer\GAL4Act5C.PI RhebAV4 eye, with Scer\GAL4GMR.PF RhebAV4 RhebEP50.084 RhebEP50.084-loxP RhebGSjE2 RhebScer\UAS.cPa RhebScer\UAS.cSa eye | somatic clone Rheb2D1 Rhebunspecified eye | somatic clone, with Scer\GAL4[-]: RhebAV4 fat body | conditional | somatic clone, with Scer\GAL4GMR.PF RhebScer\UAS.cSa fat body | somatic clone, with Scer\GAL4Act5C.PP RhebEP50.084 G1 phase RhebdsRNA.cPa head, with Scer\GAL4Act5C.PI RhebAV4 head | somatic clone, with Scer\GAL4[-]: RhebAV4 imaginal disc (with Rheb3M2) Rheb26.2 imaginal disc (with Rheb26.2) Rheb3M2 interommatidial bristle | supernumerary, with Scer\GAL4Act5C.PI RhebAV4 mitotic cell cycle, with Scer\GAL4Act5C.PP RhebScer\UAS.cSa nucleolus, with Scer\GAL4en-e16E RhebScer\UAS.cSa ommatidium, with Scer\GAL4Act5C.PI RhebAV4 ommatidium, with Scer\GAL4GMR.PF RhebEP50.084 ommatidium, with Scer\GAL4GMR.PU RhebScer\UAS.cSa ommatidium (with Rheb2G5) Rheb44.1 ommatidium (with Rheb3M2) Rheb44.1 ommatidium (with Rheb7A1) Rheb44.1 ommatidium (with Rheb44.1) Rheb2G5 Rheb3M2 Rheb7A1 ommatidium | somatic clone Rheb2D1 Rhebunspecified ommatidium | somatic clone, with Scer\GAL4[-]: RhebAV4 ovary (with Rheb7A1) Rheb44.1 ovary (with Rheb44.1) Rheb7A1 photoreceptor cell, with Scer\GAL4GMR.PF RhebScer\UAS.cSa photoreceptor cell, with Scer\GAL4GMR.PU RhebScer\UAS.cSa rhabdomere, with Scer\GAL4GMR.PU RhebScer\UAS.cSa salivary gland | conditional | somatic clone, with Scer\GAL4GMR.PF RhebScer\UAS.cSa S phase RhebAct5C.T:Zzzz\FLAG synapse, with Scer\GAL4796 RhebEP50.084-loxP wing (with Rheb3M2) Rheb44.1 wing (with Rheb7A1) Rheb44.1 wing (with Rheb44.1) Rheb3M2 Rheb7A1 wing | anterior compartment, with Scer\GAL4ap-md544 RhebScer\UAS.cPa wing | dorsal compartment, with Scer\GAL4ap-md544 RhebScer\UAS.cPa wing | posterior compartment, with Scer\GAL4ap-md544 RhebScer\UAS.cPa
Classical Alleles ( 21 )
For All Classical Alleles Show
Allele of Rheb Class Mutagen Stocks Known lesion RhebLA01053 P-element activity 2 -- RhebAV4 loss of function allele P-element activity 1 Yes Rhebc02175 piggyBac transposase 1 -- RhebEY08085 P-element activity 1 -- Rheb1TI ethyl methanesulfonate 0 Yes Rheb201 ethyl methanesulfonate 0 Yes Rheb26.2 0 -- Rheb2D1 ethyl methanesulfonate 0 -- Rheb2G5 ethyl methanesulfonate 0 Yes Rheb3M2 ethyl methanesulfonate 0 Yes Rheb44.1 Delta2-3 0 Yes Rheb4L1 ethyl methanesulfonate 0 Yes Rheb501 ethyl methanesulfonate 0 Yes Rheb56 Delta2-3 0 Yes Rheb7A1 ethyl methanesulfonate 0 Yes RhebEP50.084-loxP cre recombinase 0 Yes RhebEP50.084 0 Yes RhebGSjE2 Delta2-3 0 Yes RhebPΔ1 Delta2-3 0 Yes RhebPΔ2 Delta2-3 0 Yes Rhebunspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rheb Class Mutagen Stocks Known lesion RhebScer\UAS.cPa in vitro construct - regulatory fusion 2 Yes RhebHMS00923 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rhebt10.8 in vitro construct - genomic fragment 1 Yes Rheb1.1.Scer\UAS in vitro construct - regulatory fusion 0 Yes RhebAct5C.cHa.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes RhebAct5C.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes RhebAct5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes RhebdsRNA.cBa in vitro construct - RNAi 0 Yes RhebdsRNA.cPa in vitro construct - RNAi 0 Yes RhebGD13254 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes RhebScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes RhebScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6144 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13254} NA P{TRiP.HMS00923} NA P{UAS-Rheb.1.1} NA P{UAS-Rheb.Pa} NA P{UAS-Rheb.S} NA P{UAS-Rheb.U} NA characterization construct P{PYD2+} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}RhebEY08085 NA P{GSV1}RhebGSjE2 NA P{Mae-UAS.6.11}RhebAV4 NA P{Mae-UAS.6.11}RhebLA01053 NA miscellaneous insertions P{EP.Scer\UAS.(-loxP).BN}RhebEP50.084-loxP NA P{EP.Scer\UAS(loxP.Scer\UAS.y+).BN}RhebEP50.084 NA P{SUPor-P}CRMPKG02006 NA PBac{PB}Rhebc02175 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from direct assay (Patel et al., 2003)
Biological Process
CV term Evidence References
cell growth inferred from mutant phenotype (Patel et al., 2003) G1/S transition of mitotic cell cycle inferred from mutant phenotype (Patel et al., 2003) imaginal disc growth inferred from mutant phenotype (Patel et al., 2003) positive regulation of cell size inferred from mutant phenotype (Hall et al., 2007) positive regulation of ribosome biogenesis inferred from mutant phenotype (Hall et al., 2007) positive regulation of translation inferred from mutant phenotype (Hall et al., 2007) regulation of reactive oxygen species metabolic process inferred from mutant phenotype (Lee et al., 2010) response to starvation inferred from expression pattern (Saucedo et al., 2003) ribosome biogenesis inferred from direct assay (Grewal et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from sequence or structural similarity (Jekely, 2003) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) GTP binding inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225, InterPro:IPR020849 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Biological Process
CV term Evidence References
GTP catabolic process inferred from electronic annotation with InterPro:IPR020849 (FlyBase Curators et al., 2004-) positive regulation of cell growth traceable author statement (Manning and Cantley, 2003) small GTPase mediated signal transduction inferred from electronic annotation with InterPro:IPR001806 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR020849 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rheb allele Gene References Rheb2D1 Tsc1 (Stocker et al., 2003) Rheb7A1 Tsc1 (Stocker et al., 2003) RhebEP50.084 Tsc1 (Stocker et al., 2003) RhebPΔ1 Tsc1 (Zhang et al., 2003) RhebScer\UAS.cSa S6k (Saucedo et al., 2003) unspecified foxo (Goberdhan et al., 2005)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041191 DroID - A comprehensive database of gene and protein interactions. • FBgn0041191 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117332
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20767 Dere\GG12903 Dgri\GH18989 Dmoj\GI24491 Dper\GL21674 Dpse\GA10574 Dsec\GM10815 Dsim\GD19794 Dvir\GJ24556 Dwil\GK22414 Dyak\GE10138
Curated drosophilid orthologs	Dpse\GA10574
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008179-PA Aedes aegypti (mosquito) AGAP001902-PA Anopheles gambiae (mosquito) XP_392564.1 Apis mellifera (honey bee) XP_001944714.1 Acyrthosiphon pisum (pea aphid) 84861 Batrachochytrium dendrobatidis (chytrid fungus) 120734 Branchiostoma floridae (lancelet) 131929 Branchiostoma floridae (lancelet) BGIBMGA004703-PA Bombyx mori (silk worm) ENSBTAP00000050644 Bos taurus (bovine) CAL0003468 Candida albicans (a form of yeast) CN05105 Caenorhabditis brenneri (small nematode) CBP08385 Caenorhabditis briggsae (nematode) CE00191 Caenorhabditis elegans (worm) ENSCAFP00000035479 Canis familiaris (dog) ENSCINP00000004477 Ciona intestinalis (sea squirt) JA18341 Caenorhabditis japonica (nematode) cn02207 Cryptococcus neoformans (yeast-like fungus) CPIJ008365 Culex pipens (mosquito) ENSCPOP00000006802 Cavia porcellus (guinea pig) RP24370 Caenorhabditis remanei (nematode) 94885 Capitella spl (polychaete worm) DDB0229441 Dictyostelium discoideum (amoeba) DEHA2A10120g Debaryomyces Hansenii (yeast) 198166 Daphnia pulex (daphnia) ENSDARP00000057222 Danio rerio (zebra fish) ENSECAP00000008072 Equus caballus (horse) ENSGACP00000022031 Gymnopilus aculeatus (mushroom) ENSGALP00000009991 Gallus gallus (chicken) ENSP00000262187 Homo sapiens (human) ISCW018020-PA Ixodes scapularis (deer tick) 212557 Lottia gigantea (owl limpet) ENSMODP00000033491 Monodelphis domestica (gray opossum) ENSMMUP00000008217 Macaca mulatta (rhesus monkey) ENSMUSP00000030787 Mus musculus (house mouse) 236736 Nematostella vectensis (starlet anemone) XP_001599091.1 Nasonia vitripennis (wasp) ENSOANP00000009864 Ornithorynchus anatinus (platypus) ENSORLP00000001940 Oryzias latipes (japanese killifish) PHUM004645-PA Pediculus humanus (human body louse) ENSPPYP00000020403 Pongo pygmaeus (orangutan) 45019 Phytophthora ramorum (sudden oak death pathogen) 118341 Phytophthora sojae (root rot pathogen) ENSPTRP00000034060 Pan troglodytes (chimpanzee) ENSRNOP00000036452 Rattus norvegicus (norway rat) SPBC428.16c Schizosaccharomyces pombe (fission yeast) XP_797197.2 Strongylocentrotus purpuratus (purple sea urchin) 53571 Trichoplax adhaerens (metazoa) XP_970662.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017619 Tetraodon nigroviridis (green spotted pufferfish) 40580 Thalassiosira pseudonana (marine diatom) ENSTRUP00000030928 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000021421 Xenopus tropicalis (frog) YALI0E30943g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18289 LH13571 ISCW018020 FBgn0228019 FBgn0224393 FBgn0211636 FBgn0191283 FBgn0177963 FBgn0165761 JGI_V11_198166 FBgn0070631 FBgn0159267 FBgn0147213 FBgn0126456 FBgn0105176 FBgn0097773 CPIJ008365 BGIBMGA004703 ACYPI008618 ACYPI006392 ACYPI005487 ACYPI000378 GB16109 AGAP001902 AAEL008179 PB25177 PHUM002900 GLEAN_14205
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	9688 w*; P{UAS-Rheb.Pa}2 9689 w*; P{UAS-Rheb.Pa}3 33966 y1 sc* v1; P{TRiP.HMS00923}attP2 9690 y1 w*; P{Mae-UAS.6.11}RhebAV4/TM6B, Tb1 24479 P{PYD2+}1c, w*; b1; Df(3R)noi-B, e1/TM3, Sb1 16873 y1 w67c23; P{EPgy2}RhebEY08085/TM3, Sb1 Ser1 22248 y1 w*; P{Mae-UAS.6.11}RhebLA01053/TM3, Sb1 Ser1
Harvard	- PBac{PB}Rhebc02175
Kyoto	121053 y* w*; P{Mae-UAS.6.11}RhebLA01053
Genomic Clones ( 1 )
	BACR24O24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 82 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10361
Other clones	DPiM_GH10361
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01594 GH14625 GH14723 GH15143 GH16019 GM12218 LD31416 LP03973 LP04140 LP05834 LP06653 LP08731 LP12055 RE04516 RE27833 RE31068 RE54124 RE56403 RE59691 RE74057 SD14348 SD21375 SD26179
Other clones	8451 8884 33136 55032 57470 66194 79124 120221 166755 569730 CK01.71D.H6 Dmel_dig_000120_0632_3752 Dmel_dig_004178_0639_2748 Dmel_dig_013667_0708_2899 Dmel_neb_009097_0868_3433 EC14483 EC22461 EK056948 EK106812 EK107713 EK143551 EK177207 EK177614 EK181611 EK193762 EK251610 EK271839 EN15458 FGC005H12 FGM002B01 GM14235 IP11558 IP13558 RM07481 RM07681 RM07781 RM07881 RM08081 RM08181 RP001008643 RP001020324 RP001022188 RP001023211 RP001026760 RP001029648 RP001038572 RP001042493 RP001043290 RP001043623 RP001044636 RP001045845 RP001045861 RP001048598 RP001053042 RP001053921 RP001055599 RP001055808
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041191 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117332
Antibody Information
	polyclonal (Findlay et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rheb CG1081 (Saucedo and Edgar, 2002)
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells in the presence of Cdc27 dsRNA. This phenotype cannot be observed when the screen is performed without Cdc27 dsRNA. (Goshima et al., 2007) dsRNA made from templates generated with primers directed against this gene results in a reduced mean cell diameter. Silencing Rheb generates a cell-expression profile similar to that of rapamycin-treated cells. (Guertin et al., 2006) dsRNA made from templates generated with primers directed against this gene promotes the phosphorylation of Akt1 (dependent on TORC2) and inhibits phosphorylation of S6k in S2 cells. In addition, knockdown of Rheb enhances insulin-stimulated Akt1 phosphorylation. (Yang et al., 2006) dsRNA made from templates generated with primers directed against this gene used to treat S2 cells. (Yang et al., 2006) Signaling through Tor and its upstream regulators Pi3K92E/Pi3K21B and Rheb is necessary and sufficient to suppress starvation-induced autophagy in the fat body. (Scott et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Levels of Rheb mRNA are rapidly induced in response to protein starvation. (Saucedo et al., 2003) In mitotic tissues, overexpression of Rheb accelerates passage through G1-S phase without affecting rates of cell division, whereas in endoreplicating tissues, overexpression increases DNA ploidy. Overexpression of Rheb can also drive cell growth in starved animals. (Saucedo et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169068 NM_169069 RefSeq (Proteins) • NP_730950 NP_730951 DDBJ / EMBL / GenBank • AAF52004 AAF52005 AAM11050 AI113871 AI238559 AW940360 AY094697 CL528079 CZ467743 DU708690 Entrez Gene - A searchable database of RefSeq genes. • 117332 UniProtKB/Swiss-Prot • Q9VND8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTP-binding protein domain (IPR005225) Small GTPase superfamily, Ras type (IPR020849)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041191 DroID - A comprehensive database of gene and protein interactions. • FBgn0041191 DRSC - Results from RNAi screens. • FBgn0041191 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041191 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1081-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041191 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117332 InParanoid A subset of ortholog calls from InParanoid. • AAEL008179-PA Aedes aegypti (mosquito) AGAP001902-PA Anopheles gambiae (mosquito) XP_392564.1 Apis mellifera (honey bee) XP_001944714.1 Acyrthosiphon pisum (pea aphid) 84861 Batrachochytrium dendrobatidis (chytrid fungus) 120734 Branchiostoma floridae (lancelet) 131929 Branchiostoma floridae (lancelet) BGIBMGA004703-PA Bombyx mori (silk worm) ENSBTAP00000050644 Bos taurus (bovine) CAL0003468 Candida albicans (a form of yeast) CN05105 Caenorhabditis brenneri (small nematode) CBP08385 Caenorhabditis briggsae (nematode) CE00191 Caenorhabditis elegans (worm) ENSCAFP00000035479 Canis familiaris (dog) ENSCINP00000004477 Ciona intestinalis (sea squirt) JA18341 Caenorhabditis japonica (nematode) cn02207 Cryptococcus neoformans (yeast-like fungus) CPIJ008365 Culex pipens (mosquito) ENSCPOP00000006802 Cavia porcellus (guinea pig) RP24370 Caenorhabditis remanei (nematode) 94885 Capitella spl (polychaete worm) DDB0229441 Dictyostelium discoideum (amoeba) DEHA2A10120g Debaryomyces Hansenii (yeast) 198166 Daphnia pulex (daphnia) ENSDARP00000057222 Danio rerio (zebra fish) ENSECAP00000008072 Equus caballus (horse) ENSGACP00000022031 Gymnopilus aculeatus (mushroom) ENSGALP00000009991 Gallus gallus (chicken) ENSP00000262187 Homo sapiens (human) ISCW018020-PA Ixodes scapularis (deer tick) 212557 Lottia gigantea (owl limpet) ENSMODP00000033491 Monodelphis domestica (gray opossum) ENSMMUP00000008217 Macaca mulatta (rhesus monkey) ENSMUSP00000030787 Mus musculus (house mouse) 236736 Nematostella vectensis (starlet anemone) XP_001599091.1 Nasonia vitripennis (wasp) ENSOANP00000009864 Ornithorynchus anatinus (platypus) ENSORLP00000001940 Oryzias latipes (japanese killifish) PHUM004645-PA Pediculus humanus (human body louse) ENSPPYP00000020403 Pongo pygmaeus (orangutan) 45019 Phytophthora ramorum (sudden oak death pathogen) 118341 Phytophthora sojae (root rot pathogen) ENSPTRP00000034060 Pan troglodytes (chimpanzee) ENSRNOP00000036452 Rattus norvegicus (norway rat) SPBC428.16c Schizosaccharomyces pombe (fission yeast) XP_797197.2 Strongylocentrotus purpuratus (purple sea urchin) 53571 Trichoplax adhaerens (metazoa) XP_970662.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017619 Tetraodon nigroviridis (green spotted pufferfish) 40580 Thalassiosira pseudonana (marine diatom) ENSTRUP00000030928 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000021421 Xenopus tropicalis (frog) YALI0E30943g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/rheb1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117332 modMine - Data generated by the modENCODE project. • FBgn0041191 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18289 LH13571 ISCW018020 FBgn0228019 FBgn0224393 FBgn0211636 FBgn0191283 FBgn0177963 FBgn0165761 JGI_V11_198166 FBgn0070631 FBgn0159267 FBgn0147213 FBgn0126456 FBgn0105176 FBgn0097773 CPIJ008365 BGIBMGA004703 ACYPI008618 ACYPI006392 ACYPI005487 ACYPI000378 GB16109 AGAP001902 AAEL008179 PB25177 PHUM002900 GLEAN_14205
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG1081 (Schneider et al., 2004, Stocker et al., 2003, Saucedo et al., 2003, Saucedo, 2002.10.25, Walker et al., 2006, Goshima et al., 2007, Ni et al., 2010.12.1) Dm Rheb (Jekely, 2003) DmRheb (Urano et al., 2000) DReb (Patel et al., 2003) dRheb (Patel et al., 2003, Findlay et al., 2005, Goraksha and Neufeld, 2005, Stocker et al., 2003, Inoki and Guan, 2006, Mosimann et al., 2006, Guertin et al., 2006, Yang et al., 2006, Hsu et al., 2007, Layalle et al., 2008, Dekanty et al., 2005, Dekanty et al., 2010) Rheb (McNeill et al., 2008, Hsu and Choi, 2007, Yang et al., 2006, Reis and Edgar, 2004, Goberdhan et al., 2005, Wullschleger, 2006, Herranz et al., 2006, Knox et al., 2007, Walker et al., 2006, Friedman and Perrimon, 2006, Goraksha and Neufeld, 2008, Bakal et al., 2007, Hennig et al., 2006, Martin-Pena et al., 2006, Grewal et al., 2007, Harvey et al., 2008, Juhász et al., 2008, Scott et al., 2007, Tseng et al., 2007, Steinhilb et al., 2007, Patel and Tamanoi, 2006, Kim et al., 2008, Lee et al., 2008, Lee et al., 2010, Findlay et al., 2007, Hall et al., 2007, Chang and Neufeld, 2009, Scott et al., 2007, Nuzhdin et al., 2009, Chang and Neufeld, 2009, Lee et al., 2007, Sousa-Nunes et al., 2011, Parrish et al., 2009, Khurana et al., 2006, Doumanis et al., 2009, Patch et al., 2009, Sims et al., 2009, Liebl and Featherstone, 2005, Ribeiro and Dickson, 2010, Karbowniczek et al., 2010, Li et al., 2010, Zheng and Sehgal, 2010, Curtis et al., 2007, Haberman et al., 2010, Li et al., 2010, Nisoli et al., 2010, Barth et al., 2011, Eddison et al., 2011, Aspuria and Tamanoi, 2004) rheb (Saucedo et al., 2003, Rawls, 2006, Smith-Bolton et al., 2009, Wang et al., 2009, Parrish et al., 2009, Robinson et al., 2010, Hsieh et al., 2010) RHEB (Edgar, 2006) RheB (Goshima et al., 2007, Hoshizaki and Gibbs, 2007, Goshima et al., 2007, Hou et al., 2008)
Name Synonym	Ras homolog enriched in brain (Hall et al., 2007, Ribeiro and Dickson, 2010) Ras homologue enriched in brain (Wang et al., 2009) Ras homology enriched in brain (Yang et al., 2006) Rheb (Patch et al., 2009)
Secondary FlyBase IDs
	FBgn0037343
References ( 119 )
Generate a list of	All references relating to this gene ( 119 )
List References by type	Research paper  ( 68 ) Supplementary material  ( 9 ) Review  ( 13 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 14 ) FlyBase analysis  ( 1 ) Letter  ( 1 ) Conference report  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 16 )
	Barth et al., 2011, Cell Death Differ. 18(6): 915--924 Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis. [FBrf0213616] Cheng et al., 2011, Cell 146(3): 435--447 Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599] Eddison et al., 2011, Neuron 70(5): 979--990 arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity. [FBrf0213908] Resnik-Docampo and de Celis, 2011, PLoS ONE 6(1): e14528 MAP4K3 Is a Component of the TORC1 Signalling Complex that Modulates Cell Growth and Viability in Drosophila melanogaster. [FBrf0212911] Sousa-Nunes et al., 2011, Nature 471(7339): 508--512 Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. [FBrf0214426] Dekanty et al., 2010, PLoS Genet. 6(6): e1000994 Drosophila Genome-Wide RNAi Screen Identifies Multiple Regulators of HIF-Dependent Transcription in Hypoxia. [FBrf0211155] Haberman et al., 2010, Development 137(13): 2157--2166 Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking. [FBrf0211007] Hsieh et al., 2010, PLoS Genet. 6(8): Tuberous Sclerosis Complex 1 Regulates dE2F1 Expression during Development and Cooperates with RBF1 to Control Proliferation and Survival. [FBrf0211700] Karbowniczek et al., 2010, J. clin. Invest. 120(1): 93--102 The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. [FBrf0209596] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Li et al., 2010, Cancer Cell 17(5): 469--480 Specific Killing of Rb Mutant Cancer Cells by Inactivating TSC2. [FBrf0210758] Li et al., 2010, J. Biol. Chem. 285(26): 19705--19709 Regulation of mTORC1 by the Rab and Arf GTPases. [FBrf0211071] Nisoli et al., 2010, Cell Death Differ. 17(10): 1577--1587 Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy. [FBrf0212035] Ribeiro and Dickson, 2010, Curr. Biol. 20(11): 1000--1005 Sex peptide receptor and neuronal TOR/S6K signaling modulate nutrient balancing in Drosophila. [FBrf0210987] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Zheng and Sehgal, 2010, Curr. Biol. 20(13): 1203--1208 AKT and TOR Signaling Set the Pace of the Circadian Pacemaker. [FBrf0211221] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...