• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\AttC

General Information
Symbol	Dmel\AttC	Species	D. melanogaster
Name	Attacin-C	Annotation symbol	CG4740
Feature type	protein_coding_gene	FlyBase ID	FBgn0041579
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Att
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	50A3-50A3	Sequence location	2R:9,281,210..9,282,172 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Attacin-C is referred to in FlyBase by the symbol Dmel\AttC (CG4740, FBgn0041579). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: humoral immune response; defense response to Gram-positive bacterium; defense response; antibacterial humoral response. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Attacin, C-terminal; Attacin, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1641419_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of AttC. Gene sequence location is 2R:9281210..9282172.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Jumbo-Lucioni et al., 2010, BMC Genomics 11: 297 Sequence features HFA06886 BKN27193
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50A3-50A3   Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
Experimentally Determined Cytological Location
Cytogenetic map Notes References 50A-50A     (Hedengren, 2000.11.20) 50A-51A     (Lazzaro, 2000.3.9)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\AttC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Probable mutation in sequenced strain; 8bp deletion in first exon.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) AttC-RB FBtr0305795     900   241
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein AttC-PB   FBpp0297062   25.5   241   10.45
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Attacin, N-terminal (IPR005520) Attacin, C-terminal (IPR005521)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF322248 AAG42832   AF322249 AAG42833   AY056843 AAL23629   AY056844 AAL23630   AY056845 AAL23631   AY056846 AAL23632   AY056847 AAL23633   AY056848 AAL23634   AY056849 AAL23635   AY056850 AAL23636   AY056851 AAL23637   AY056852 AAL23638   AY056853 AAL23639   AY056854 AAL23640   AY056879   AY056880   AY056881   AY056882   AY056883   AY056884   AY056885   AY056886   AY056887   AY056888   AY056889   AY056890   BT024432   EL870470   GH291386
UniProtKB/Swiss-Prot	Q95NH6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041579    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041579 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041579 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old    123 larva L3 puffstage 1-2    391 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    172 white prepupae new    306 white prepupae 12hr    835 white prepupae 24hr    763 pupae 2d postWPP    351 pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day    242 adult male 05day    99 adult male 30day    582 adult female 01day    1728 adult female 05day    387 adult female 30day    1708 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old  (123) larva L3 puffstage 1-2  (391) larva L3 puffstage 3-6  (509) larva L3 puffstage 7-9  (172) white prepupae new  (306) white prepupae 12hr  (835) white prepupae 24hr  (763) pupae 2d postWPP  (351) pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day  (242) adult male 05day    99 adult male 30day  (582) adult female 01day  (1728) adult female 05day  (387) adult female 30day  (1708) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old    123 larva L3 puffstage 1-2    391 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    172 white prepupae new    306 white prepupae 12hr    835 white prepupae 24hr    763 pupae 2d postWPP    351 pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day    242 adult male 05day    99 adult male 30day    582 adult female 01day  (1728) adult female 05day    387 adult female 30day  (1708) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old    123 larva L3 puffstage 1-2    391 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    172 white prepupae new    306 white prepupae 12hr    835 white prepupae 24hr    763 pupae 2d postWPP    351 pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day    242 adult male 05day    99 adult male 30day    582 adult female 01day    1728 adult female 05day    387 adult female 30day    1708 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old    123 larva L3 puffstage 1-2    391 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    172 white prepupae new    306 white prepupae 12hr    835 white prepupae 24hr    763 pupae 2d postWPP    351 pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day    242 adult male 05day    99 adult male 30day    582 adult female 01day    1728 adult female 05day    387 adult female 30day    1708 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041579 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old    123 larva L3 puffstage 1-2    391 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    172 white prepupae new    306 white prepupae 12hr    835 white prepupae 24hr    763 pupae 2d postWPP    351 pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day    242 adult male 05day    99 adult male 30day    582 adult female 01day    1728 adult female 05day    387 adult female 30day    1708 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old  123 larva L3 puffstage 1-2  (391) larva L3 puffstage 3-6  (509) larva L3 puffstage 7-9  (172) white prepupae new  (306) white prepupae 12hr  (835) white prepupae 24hr  (763) pupae 2d postWPP  (351) pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day  (242) adult male 05day    99 adult male 30day  (582) adult female 01day  (1728) adult female 05day  (387) adult female 30day  (1708) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old    123 larva L3 puffstage 1-2    391 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    172 white prepupae new    306 white prepupae 12hr    835 white prepupae 24hr    763 pupae 2d postWPP    351 pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day    242 adult male 05day    99 adult male 30day    582 adult female 01day  1728 adult female 05day    387 adult female 30day  1708 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old    123 larva L3 puffstage 1-2    391 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    172 white prepupae new    306 white prepupae 12hr    835 white prepupae 24hr    763 pupae 2d postWPP    351 pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day    242 adult male 05day    99 adult male 30day    582 adult female 01day    1728 adult female 05day    387 adult female 30day    1708 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    6 embryo 20-22hr    0 embryo 22-24hr    4 larva L1    4 larva L2    14 larva L3 12hr old    123 larva L3 puffstage 1-2    391 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    172 white prepupae new    306 white prepupae 12hr    835 white prepupae 24hr    763 pupae 2d postWPP    351 pupae 3d postWPP    77 pupae 4d postWPP    74 adult male 01day    242 adult male 05day    99 adult male 30day    582 adult female 01day    1728 adult female 05day    387 adult female 30day    1708 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041579    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041579 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041579 expression level Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut no informative data Larval Hindgut    66.7 Larval Malpighian Tubules no informative data Larval Fat Body    1362.2 Larval Salivary Gland no informative data Larval Trachea    103.65 Larval Carcass no informative data Adult Head    1460 Adult Eye    1998.35 Adult Brain    66.9 Adult Thoracic-Abdominal Ganglion    37.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    107.7 Adult Malpighian Tubules no informative data Adult Fat Body    1128.5 Adult Salivary Gland no informative data Adult Heart    625.525 Adult VirginFemale Spermatheca    3374.1 Adult InseminatedFemale Spermatheca    1375 Adult Ovary    9.1 Adult Testis    26.3 Adult Male Accessory Gland no informative data Adult Carcass    542.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut no informative data Larval Hindgut    66.7 Larval Malpighian Tubules no informative data Larval Fat Body  (1362.2) Larval Salivary Gland no informative data Larval Trachea    103.65 Larval Carcass no informative data Adult Head  (1460) Adult Eye  (1998.35) Adult Brain    66.9 Adult Thoracic-Abdominal Ganglion    37.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    107.7 Adult Malpighian Tubules no informative data Adult Fat Body  (1128.5) Adult Salivary Gland no informative data Adult Heart  (625.525) Adult VirginFemale Spermatheca  (3374.1) Adult InseminatedFemale Spermatheca  (1375) Adult Ovary    9.1 Adult Testis    26.3 Adult Male Accessory Gland no informative data Adult Carcass  (542.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut no informative data Larval Hindgut    66.7 Larval Malpighian Tubules no informative data Larval Fat Body  (1362.2) Larval Salivary Gland no informative data Larval Trachea    103.65 Larval Carcass no informative data Adult Head  (1460) Adult Eye  (1998.35) Adult Brain    66.9 Adult Thoracic-Abdominal Ganglion    37.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    107.7 Adult Malpighian Tubules no informative data Adult Fat Body  (1128.5) Adult Salivary Gland no informative data Adult Heart    625.525 Adult VirginFemale Spermatheca  (3374.1) Adult InseminatedFemale Spermatheca  (1375) Adult Ovary    9.1 Adult Testis    26.3 Adult Male Accessory Gland no informative data Adult Carcass    542.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut no informative data Larval Hindgut    66.7 Larval Malpighian Tubules no informative data Larval Fat Body    1362.2 Larval Salivary Gland no informative data Larval Trachea    103.65 Larval Carcass no informative data Adult Head    1460 Adult Eye    1998.35 Adult Brain    66.9 Adult Thoracic-Abdominal Ganglion    37.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    107.7 Adult Malpighian Tubules no informative data Adult Fat Body    1128.5 Adult Salivary Gland no informative data Adult Heart    625.525 Adult VirginFemale Spermatheca    3374.1 Adult InseminatedFemale Spermatheca    1375 Adult Ovary    9.1 Adult Testis    26.3 Adult Male Accessory Gland no informative data Adult Carcass    542.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041579 expression level Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut no informative data Larval Hindgut    66.7 Larval Malpighian Tubules no informative data Larval Fat Body    1362.2 Larval Salivary Gland no informative data Larval Trachea    103.65 Larval Carcass no informative data Adult Head    1460 Adult Eye    1998.35 Adult Brain    66.9 Adult Thoracic-Abdominal Ganglion    37.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    107.7 Adult Malpighian Tubules no informative data Adult Fat Body    1128.5 Adult Salivary Gland no informative data Adult Heart    625.525 Adult VirginFemale Spermatheca    3374.1 Adult InseminatedFemale Spermatheca    1375 Adult Ovary    9.1 Adult Testis    26.3 Adult Male Accessory Gland no informative data Adult Carcass    542.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut no informative data Larval Hindgut    66.7 Larval Malpighian Tubules no informative data Larval Fat Body  (1362.2) Larval Salivary Gland no informative data Larval Trachea    103.65 Larval Carcass no informative data Adult Head  (1460) Adult Eye  (1998.35) Adult Brain    66.9 Adult Thoracic-Abdominal Ganglion    37.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    107.7 Adult Malpighian Tubules no informative data Adult Fat Body  (1128.5) Adult Salivary Gland no informative data Adult Heart  625.525 Adult VirginFemale Spermatheca  (3374.1) Adult InseminatedFemale Spermatheca  (1375) Adult Ovary    9.1 Adult Testis    26.3 Adult Male Accessory Gland no informative data Adult Carcass  542.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut no informative data Larval Hindgut    66.7 Larval Malpighian Tubules no informative data Larval Fat Body  1362.2 Larval Salivary Gland no informative data Larval Trachea    103.65 Larval Carcass no informative data Adult Head  1460 Adult Eye  (1998.35) Adult Brain    66.9 Adult Thoracic-Abdominal Ganglion    37.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    107.7 Adult Malpighian Tubules no informative data Adult Fat Body  1128.5 Adult Salivary Gland no informative data Adult Heart    625.525 Adult VirginFemale Spermatheca  (3374.1) Adult InseminatedFemale Spermatheca  1375 Adult Ovary    9.1 Adult Testis    26.3 Adult Male Accessory Gland no informative data Adult Carcass    542.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut no informative data Larval Hindgut    66.7 Larval Malpighian Tubules no informative data Larval Fat Body    1362.2 Larval Salivary Gland no informative data Larval Trachea    103.65 Larval Carcass no informative data Adult Head    1460 Adult Eye    1998.35 Adult Brain    66.9 Adult Thoracic-Abdominal Ganglion    37.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    107.7 Adult Malpighian Tubules no informative data Adult Fat Body    1128.5 Adult Salivary Gland no informative data Adult Heart    625.525 Adult VirginFemale Spermatheca    3374.1 Adult InseminatedFemale Spermatheca    1375 Adult Ovary    9.1 Adult Testis    26.3 Adult Male Accessory Gland no informative data Adult Carcass    542.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1460   NA  Eye    1998.35   NA  Brain    66.9   5.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    37.7   NA  Crop    no informative data   no informative data  Midgut    no informative data   66.7  Hindgut    107.7   no informative data  Malpighian Tubules    no informative data   1362.2  Fat Body    1128.5   no informative data  Salivary Gland    no informative data   NA  Heart    625.525   103.65  Trachea    NA   NA  VirginFemale Spermatheca    3374.1   NA  InseminatedFemale Spermatheca    1375   NA  Ovary    9.1   NA  Testis    26.3   NA  Male Accessory Gland    no informative data   no informative data  Carcass    542.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041579 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4740-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 AttCGD1647 AttCGD15180 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of AttC Class Mutagen Stocks Known lesion AttCMB05438 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of AttC Class Mutagen Stocks Known lesion AttCGD1647 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AttCGD15180 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AttCKK107193 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1647} NA P{GD15180} NA P{KK107193} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}AttCMB05438 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from direct assay (Uttenweiler-Joseph et al., 1998) defense response inferred from direct assay (Uttenweiler-Joseph et al., 1998) defense response to Gram-positive bacterium inferred from expression pattern (Gordon et al., 2008) humoral immune response inferred from expression pattern (Verleyen et al., 2006)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (Uttenweiler-Joseph et al., 1998) extracellular space inferred from direct assay (Liu et al., 2006, Verleyen et al., 2006)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from sequence or structural similarity with AttA AND inferred from sequence or structural similarity with AttB (Borge, 2000.11.20) non-traceable author statement (Lazzaro and Clark, 2000) defense response to bacterium non-traceable author statement (Lazzaro and Clark, 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions AttC allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62245 DroID - A comprehensive database of gene and protein interactions. • FBgn0041579 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36484
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13689 Dere\GG20378 Dgri\GH21628 Dsec\GM21465 Dsim\AttC Dvir\GJ21173 Dwil\GK17822 Dyak\GE12538
Curated drosophilid orthologs	Dsim\AttC (Lazzaro and Clark, 2001)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230272 FBgn0219821 FBgn0208306 FBgn0046916 FBgn0176346 FBgn0131209 FBgn0129089 FBgn0112569 FBgn0090717 BGIBMGA002747 BGIBMGA002739
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	25598 w1118; Mi{ET1}AttCMB05438
VDRC	v101213 P{KK107193}VIE-260B v42859 w1118 P{GD1647}v42859 v47041 w1118; P{GD15180}v47041 v42860 w1118; P{GD1647}v42860/CyO
Genomic Clones ( 1 )
	BACR48I15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP02545
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	DMG5-chr2R.16.010.pred.a IP02548
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041579 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36484
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: AttC DIM-16 (FlyBase, 1996-)
Source for database merge of	Source for merge of: AttC CG4740 (FlyBase, 1996-)
Additional comments	Source for identity of AttC DIM-16 was sequence comparison (date:031215). (FlyBase, 1996-) Source for merge of AttC CG4740 was sequence comparison (date:010102). (FlyBase, 1996-)
Other Comments
	Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background. (McDonald and Rosbash, 2001) Identification: Encodes a protein that is induced by immune challenge. (Uttenweiler-Joseph et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AAG42832 AAG42833 AAL23629 AAL23630 AAL23631 AAL23632 AAL23633 AAL23634 AAL23635 AAL23636 AAL23637 AAL23638 AAL23639 AAL23640 AAM68570 AF322248 AF322249 AY056843 AY056844 AY056845 AY056846 AY056847 AY056848 AY056849 AY056850 AY056851 AY056852 AY056853 AY056854 AY056879 AY056880 AY056881 AY056882 AY056883 AY056884 AY056885 AY056886 AY056887 AY056888 AY056889 AY056890 Entrez Gene - A searchable database of RefSeq genes. • 36484 UniProtKB/Swiss-Prot • Q95NH6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Attacin, N-terminal (IPR005520) Attacin, C-terminal (IPR005521)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62245 DroID - A comprehensive database of gene and protein interactions. • FBgn0041579 DRSC - Results from RNAi screens. • FBgn0041579 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041579 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4740-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041579 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36484 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36484 modMine - Data generated by the modENCODE project. • FBgn0041579 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230272 FBgn0219821 FBgn0208306 FBgn0046916 FBgn0176346 FBgn0131209 FBgn0129089 FBgn0112569 FBgn0090717 BGIBMGA002747 BGIBMGA002739
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	Att (Takehana et al., 2002, Gottar et al., 2002, Bergeret et al., 2008) att (Georgel et al., 2001) AttC (Sackton and Clark, 2009, Chen et al., 2010, Blanco et al., 2010, Waterhouse et al., 2007, Lazzaro et al., 2004, Allen and Spradling, 2008, Feng et al., 2009, Buchon et al., 2009, Domanitskaya et al., 2007, Jumbo-Lucioni et al., 2010) attC (Winterhalter and Fedorka, 2009, Marshall and Sinclair, 2010, Sharma et al., 2011) att C (Zsindely et al., 2009) CG4740 (Pal et al., 2007, Irving et al., 2001, McDonald and Rosbash, 2001, De Gregorio et al., 2001, Mount, 2001.8.14, Lemaitre, 2000.12.20, Hultmark, 2001.1.10, Borge, 2000.11.20, Sano et al., 2005, Liu et al., 2006, Winterhalter and Fedorka, 2009, Keleman et al., 2009.8.5, Verleyen et al., 2006, Hernandez-Romano et al., 2008) DIM-16 (Rabel et al., 2004) DIM 16 (Uttenweiler-Joseph et al., 1998) MPAC (Rabel et al., 2004)
Name Synonym	attacin (Okado et al., 2009, Delaney et al., 2005, Steiner, 2004, Leclerc and Reichhart, 2004, Mellroth et al., 2003, Delaney and Anderson, 2002, Delaney and Anderson, 2001, Aderem and Ulevitch, 2000, Georgel et al., 2001, Zelinger and Heifetz, 2006, Avet-Rochex et al., 2005, Persson et al., 2007, Bhattacharya and Steward, 2002, Marshall and Sinclair, 2010) Attacin (Pal et al., 2007, Brennan and Anderson, 2004, Kurz and Ewbank, 2003, Kimbrell and Beutler, 2001, Rutschmann et al., 2000, Barillas-Mury et al., 2000, Martin-Blanco, 2000, Govind, 1999, Zhou et al., 2005, Huh et al., 2007, Bergeret et al., 2008, Wu et al., 2007, Costa et al., 2009, Ooi et al., 2002, Zhao et al., 2010) Attacin C (Boutros et al., 2002, Lazzaro and Clark, 2001, Lazzaro et al., 2006, Lai et al., 2007, Lazzaro et al., 2004, Verleyen et al., 2006, Xi et al., 2008, Gordon et al., 2008) attacin C (Lazzaro and Clark, 2000, Feng et al., 2009, Radyuk et al., 2010) Attacin-C (Lazzaro and Clark, 2000, Johansson et al., 2005) AttacinC (Ligoxygakis et al., 2002) attacin-C (Domanitskaya et al., 2007) Attacin-C precursor (Hernandez-Romano et al., 2008) Attackin (Pletcher et al., 2002) Drosophila Immune induced molecule 16 (Uttenweiler-Joseph et al., 1998)
Secondary FlyBase IDs
	FBgn0033833
References ( 87 )
Generate a list of	All references relating to this gene ( 87 )
List References by type	Research paper  ( 56 ) Supplementary material  ( 2 ) Review  ( 9 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 7 )
	Sharma et al., 2011, Chemosphere 82(3): 370--376 Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. [FBrf0212610] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Chen et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(48): 20774--20779 Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. [FBrf0212390] Jumbo-Lucioni et al., 2010, BMC Genomics 11: 297 Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. [FBrf0210956] Marshall and Sinclair, 2010, Proc. Biol. Sci. 277(1683): 963--969 Repeated stress exposure results in a survival-reproduction trade-off in Drosophila melanogaster. [FBrf0209895] Radyuk et al., 2010, Biochim. biophys. Acta 1800(11): 1153--1163 Peroxiredoxin 5 modulates immune response in Drosophila. [FBrf0211669] Zhao et al., 2010, PLoS ONE 5(7): e11701 Experimental selection for Drosophila survival in extremely high o(2) environments. [FBrf0211379] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...