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Gene Dmel\olf186-F

General Information
Symbol	Dmel\olf186-F	Species	D. melanogaster
Name	olf186-F	Annotation symbol	CG11430
Feature type	protein_coding_gene	FlyBase ID	FBgn0041585
Gene Model Status	Current	Stock availability	24 publicly available
Also Known As	Orai, dOrai, CRACM1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54F1-54F3	Sequence location	2R:13,730,947..13,748,087 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene olf186-F is referred to in FlyBase by the symbol Dmel\olf186-F (CG11430, FBgn0041585). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: store-operated calcium channel activity. There is experimental evidence that it is involved in the biological process: nervous system development; positive regulation of calcium ion transport; positive regulation of NFAT protein import into nucleus; store-operated calcium entry. 28 alleles are reported. The phenotype of these alleles is annotated with: dorsal medial muscle. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Calcium release-activated calcium channel protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. Gene sequence location is 2R:13730947..13748087.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54F1-54F3   Limits computationally determined from genome sequence between P{PZ}grh06850&P{lacW}olf186-Fk11505 and P{PZ}Hsf03091&P{EP}Dgp-1EP731
Experimentally Determined Cytological Location
Cytogenetic map Notes References 54F-54F     (Chodagam, 1999.9.20) 54F1-54F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 54F1-54F2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\olf186-F for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) olf186-F-RA FBtr0086797  NM_170626   2080   351 olf186-F-RB FBtr0086795  NM_137429   2632   351 olf186-F-RE FBtr0114614  NM_001144224   3581   507 olf186-F-RF FBtr0336698  NM_206159   2407   351 olf186-F-RG FBtr0336699  NM_001274134   4582   507
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein olf186-F-PA   FBpp0085976   38.5   351   7.83     NP_725727   AAF57780 olf186-F-PB   FBpp0085974   38.5   351   7.83     NP_611273   AAM68473 olf186-F-PE   FBpp0113106   55.7   507   7.63     NP_001137696   ACL83150 olf186-F-PF   FBpp0307679   38.5   351   7.83     NP_995881   AAS64814 olf186-F-PG   FBpp0307680   55.7   507   7.63     NP_001261063   AGB93595
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Calcium release-activated calcium channel protein (IPR012446)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202888   AE013599 AAF57780   AE013599 AAM68473   AE013599 AAS64814   AE013599 ACL83150   AF188634 AAF01457   AE013599 AGB93595   AI543738   AQ025967   AW941517   AW944651   AY071273 AAL48895   BE975483   BE977583   BE978144   BF490525   BG640870   BI234680   BI242505   BI367699   BI367727   BI369477   BI482168   BI485021   BI578371   BI631221   BI641643   BT001876 AAN71648   BT003591 AAO39594   BX013548   CL526085   CL705882   CL943519   CO178360   CO189451   CO192596   CO263985   CO265488   CO268961   CO269388   CO269669   CO274745   CO276105   CO279505   CO285682   CO303019   CO318938   CO319723   CO322428   CO326416   CO328978   CO342516   CO342842   CO344154   CZ466468   CZ472884   CZ472885   CZ473955   CZ475056   CZ475057   CZ476814   CZ477929   CZ477930   CZ479389   CZ479390   CZ484784   CZ485246   CZ485247   CZ486188   EC062431   EC074510   EC195355   EC195824   EC206653   EC208741   EC210610   EC215874   EC220012   EC227448   EC232642   EC234978   EC239017   EC253641   EC254129   EC258377
UniProtKB/Swiss-Prot	Q9U6B8
UniProtKB/TrEMBL	B7YZJ7 E2QCH2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    36 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female  (36) ovary, mated 4-day female  (32) testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    36 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    36 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    36 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female  (36) ovary, mated 4-day female  32 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    36 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    36 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    12 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    7 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    11 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    12 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    7 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    11 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    12 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    7 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    11 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    12 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    7 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    11 adult female 05day    16 adult female 30day    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    12 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    7 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    11 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    12 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    7 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    11 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    12 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    7 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    11 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    12 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    7 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    11 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    7 embryonic 1182-4H    16 embryonic GM2    13 embryonic Kc167    6 embryonic S1    13 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    22 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    2 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    12 ovary fGS/OSS    7 ovary OSC    4 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4    7 embryonic 1182-4H    16 embryonic GM2    13 embryonic Kc167    6 embryonic S1    13 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    22 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    2 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    12 ovary fGS/OSS    7 ovary OSC    4 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    7 embryonic 1182-4H    16 embryonic GM2    13 embryonic Kc167    6 embryonic S1    13 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    22 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    2 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    12 ovary fGS/OSS    7 ovary OSC    4 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    7 embryonic 1182-4H    16 embryonic GM2    13 embryonic Kc167    6 embryonic S1    13 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    22 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    2 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    12 ovary fGS/OSS    7 ovary OSC    4 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    7 embryonic 1182-4H    16 embryonic GM2    13 embryonic Kc167    6 embryonic S1    13 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    22 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    2 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    12 ovary fGS/OSS    7 ovary OSC    4 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4    7 embryonic 1182-4H    16 embryonic GM2    13 embryonic Kc167    6 embryonic S1    13 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    22 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    2 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    12 ovary fGS/OSS    7 ovary OSC    4 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    7 embryonic 1182-4H    16 embryonic GM2    13 embryonic Kc167    6 embryonic S1    13 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    22 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    2 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    12 ovary fGS/OSS    7 ovary OSC    4 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    7 embryonic 1182-4H    16 embryonic GM2    13 embryonic Kc167    6 embryonic S1    13 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    22 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    2 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    12 ovary fGS/OSS    7 ovary OSC    4 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (33) Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (33) Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD03241 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041585 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11430-RB;CG11430-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 olf186-FGD3554 lethal | recessive olf186-Fk11505 viable olf186-FEY01467 olf186-FEY11818 Sterility Allele fertile olf186-FEY01467 olf186-FEY11818 Phenotype manifest in Allele dorsal medial muscle, with Scer\GAL4Trh.PB olf186-FGD3554
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of olf186-F Class Mutagen Stocks Known lesion olf186-FEY09167 P-element activity 2 -- olf186-Fk11505 hypermorphic allele - genetic evidence P-element activity 2 -- olf186-F5-SZ-3325 1 -- olf186-F5-SZ-3357 1 -- olf186-Fc00450 piggyBac transposase 1 -- olf186-Fc02989 1 -- olf186-FCB-0148-3 1 -- olf186-Fd02557 P-element activity 1 -- olf186-Fd04483 P-element activity 1 -- olf186-Fd06331 P-element activity 1 -- olf186-Fe00019 piggyBac transposase 1 -- olf186-FEY01467 hypermorphic allele - genetic evidence P-element activity 1 -- olf186-FEY11818 P-element activity 1 -- olf186-Ff02279 piggyBac transposase 1 -- olf186-Ff02699 piggyBac transposase 1 -- olf186-FKG07396 1 -- olf186-FMB10834 1 -- olf186-FMI00110 1 -- olf186-FNP0646 1 -- olf186-FNP1536 1 -- olf186-Fd09569 P-element activity 0 -- olf186-Fe01578 piggyBac transposase 0 -- olf186-Fe02088 0 -- olf186-Ff03612 piggyBac transposase 0 -- olf186-FUJB6 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of olf186-F Class Mutagen Stocks Known lesion olf186-FGD3554 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes olf186-FAct5C.PZ in vitro construct - regulatory fusion 0 -- olf186-FScer\UAS.cZa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)PC4 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Pcl7B (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)RM2-1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3554} NA P{UAS-Orai.Z} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}olf186-Fk11505 No insertion of mobile activating element P{EPgy2}olf186-FEY01467 NA P{EPgy2}olf186-FEY09167 NA P{EPgy2}olf186-FEY11818 NA P{GSV1}EP-687EP-687 NA P{XP}olf186-Fd02557 NA P{XP}olf186-Fd04483 NA P{XP}olf186-Fd06331 NA P{XP}olf186-Fd09569 NA miscellaneous insertions ?{}olf186-FUJB6 NA Mi{MIC}olf186-FMI00110 NA P{RS3}olf186-FCB-0148-3 NA P{RS5}olf186-F5-SZ-3325 NA P{RS5}olf186-F5-SZ-3357 NA P{SUPor-P}olf186-FKG07396 NA PBac{PB}olf186-Fc00450 NA PBac{PB}olf186-Fc02989 NA PBac{RB}olf186-Fe00019 NA PBac{RB}olf186-Fe01578 NA PBac{RB}olf186-Fe02088 NA PBac{WH}olf186-Ff02279 NA PBac{WH}olf186-Ff02699 NA PBac{WH}olf186-Ff03612 NA insertion of enhancer trap binary system Mi{ET1}olf186-FMB10834 No P{GawB}olf186-FNP0646 No P{GawB}olf186-FNP1536 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
store-operated calcium channel activity inferred from mutant phenotype (Gwack et al., 2007)
Biological Process
CV term Evidence References
nervous system development inferred from mutant phenotype (Koizumi et al., 2007) positive regulation of calcium ion transport inferred from mutant phenotype (assigned by UniProtKB) (Feske et al., 2006) positive regulation of NFAT protein import into nucleus inferred from mutant phenotype (Gwack et al., 2007) inferred from mutant phenotype (assigned by UniProtKB) (Feske et al., 2006) store-operated calcium entry inferred from mutant phenotype (Venkiteswaran and Hasan, 2009, Vig et al., 2006, Gwack et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
NOT serine-type endopeptidase activity non-traceable author statement (Ross et al., 2003)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane non-traceable author statement (assigned by UniProtKB) (Feske et al., 2006)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
olf186-F - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Arl2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Arpc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Art8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG1129 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG14482 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG14767 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG1667 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG17754 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG2064 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG3164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG32138 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG33253 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG33303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG5447 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG7668 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - CG8034 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - DnaJ-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Hsp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - KdelR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - MRP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Mtpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Plod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Prosα4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Pvr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - R anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Rab4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Rpb8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Sc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Scamp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Src64B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Syb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Tapδ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Ubqn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - Vha68-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - ZnT63C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - cpb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - drk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - fax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - gish anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - mrj anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - sax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - sty anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - tkv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) olf186-F - wal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions olf186-F allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62725 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041585 DroID - A comprehensive database of gene and protein interactions. • FBgn0041585 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37040
Orthologs
OrthoDB Orthologs (51) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6640XX Dipteran inclusive ortholog search EOG6RBQT8 Insect inclusive ortholog search EOG6G1KC8 Arthropod inclusive ortholog search EOG6JH9XG Metazoa inclusive ortholog search EOG6HMX58
Orthologs in Drosophila Species (EOG6640XX)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\olf186-F     Drosophila simulans   Dsim\GD11325     Drosophila sechellia   Dsec\GM21831 Y   Drosophila erecta   Dere\GG21831 Y   Drosophila yakuba   Dyak\GE11907 Y   Drosophila ananassae   Dana\GF11682 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11002 Y   Drosophila persimilis   Dper\GL17231 Y   Drosophila willistoni   Dwil\GK23464     Drosophila willistoni   Dwil\GK22234     Drosophila virilis   Dvir\GJ22252 Y   Drosophila mojavensis   Dmoj\GI19120 Y   Drosophila grimshawi   Dgri\GH22031 Y
Orthologs in non-Drosophila Dipterans (EOG6RBQT8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001599   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015437   Anopheles gambiae Malaria mosquito  Agam\AGAP005071   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007873
Orthologs in non-Dipteran Insects (EOG6G1KC8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46906   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003854   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14850   Atta cephalotes Leafcutter ant  Acep\ACEP18431   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20509   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22159   Linepithema humile Argentine ant  Lhum\LH23376   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17102   Solenopsis invicta Red fire ant  Sinv\SINV20029   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002512   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004854   Bombyx mori Silkmoth  Bmor\Orai1   Pediculus humanus Human body louse  Phum\PHUM098420   Tribolium castaneum Red flour beetle  Tcas\TC016005
Orthologs in non-Insect Arthropods (EOG6JH9XG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_192146   Ixodes scapularis Deer tick  Isca\ISCW018630
Orthologs in non-Arthropod Metazoa (EOG6HMX58)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\orai-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003592gn   Danio rerio Zebrafish  Drer\si:dkey-261j4.7   Danio rerio Zebrafish  Drer\ENSDARG00000004154   Danio rerio Zebrafish  Drer\ENSDARG00000011515   Xenopus tropicalis Western clawed frog  Xtro\orai1   Xenopus tropicalis Western clawed frog  Xtro\orai2   Gallus gallus Domestic chicken  Ggal\ORAI1   Gallus gallus Domestic chicken  Ggal\ORAI2   Mus musculus House mouse  Mmus\Orai2-ps   Mus musculus House mouse  Mmus\Orai3   Mus musculus House mouse  Mmus\Orai1   Mus musculus House mouse  Mmus\Orai2   Rattus norvegicus Norway rat  Rnor\Orai3   Rattus norvegicus Norway rat  Rnor\Orai1   Rattus norvegicus Norway rat  Rnor\Orai2   Homo sapiens Human  Hsap\ENSG00000182500   Homo sapiens Human  Hsap\ORAI3
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000182500     Hsap\ORAI3
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM21831 Drosophila erecta Dere\GG21831 Drosophila yakuba Dyak\GE11907 Drosophila ananassae Dana\GF11682 Drosophila pseudoobscura pseudoobscura Dpse\GA11002 Drosophila persimilis Dper\GL17231 Drosophila virilis Dvir\GJ22252 Drosophila mojavensis Dmoj\GI19120 Drosophila grimshawi Dgri\GH22031
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Harvard	- P{XP}olf186-Fd02557 - P{XP}olf186-Fd04483 - P{XP}olf186-Fd06331 - PBac{PB}olf186-Fc00450 - PBac{PB}olf186-Fc02989 - PBac{RB}olf186-Fe00019 - PBac{WH}olf186-Ff02279 - PBac{WH}olf186-Ff02699
Kyoto	123055 w1118; P{RS3}olf186-FCB-0148-3 125994 w1118; P{RS5}olf186-F5-SZ-3325
VDRC	v12223 w1118 P{GD3554}v12223 v12221 w1118; P{GD3554}v12221
	More stocks available...
Genomic Clones ( 1 )
	BACR20E20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD03241 RE30427 SD10626
Other clones	DPiM_RE30427
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT27019 RE39861 RE53503 RE53550 RE55670 RE64826 RE68257 RE72237 RH60752 SD25111
Other clones	13525 38798 53612 62124 62233 175179 175569 214405.71 214417.67 214435.67 bs43e05 bs66c11 bs74e01 CK01.41C.D5 CK01.54C.F11 CK01.71B.D11 CK01.123D.H6 CK01.129A.D5 EC34122 EK044322 EK056516 EK093203 EK094263 EK095512 EK115317 EK119707 EK134904 EK137104 EK142804 EK169848 EK185356 EK188117 EK275326 EK280139 EK291764 EP03859 EP15041 EP15611 EP18747 SD12035
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041585 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37040
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "Orai" - in Greek mythology, the Orai are keepers of the gates of heaven: Eunomia (Order or Harmony), Dike (Justice) and Eirene (Peace). (Feske et al., 2006)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: olf186-F BcDNA:LD03241 (FlyBase, 1996-) Source for merge of: olf186-F CG11430 (Bayraktaroglu, 2000.4.27) Source for merge of: olf186-F l(2)k11505 (FlyBase, 1996-)
Additional comments	Source for merge of olf186-F l(2)k11505 was sequence comparison (date:050919). (FlyBase, 1996-) Source for merge of olf186-F BcDNA:LD03241 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	S2R+ cells treated with dsRNA made from templates generated with primers against this gene show complete inhibition of thapsigargin-induced Ca2+ influx, but there is no effect on the filling state of Ca2+ stores. (Feske et al., 2006) Treatment of S2 cells with dsRNA made from templates generated with primers directed against this gene inhibits both the early and sustained components of Ca2+ entry evoked by thapsigargin at the single-cell level. In the majority of treated cells, Ca2+ release-activated Ca2+ current is completely suppressed. (Zhang et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137429 NM_170626 NM_206159 NM_001144224 NM_001274134 RefSeq (Proteins) • NP_611273 NP_725727 NP_995881 NP_001137696 NP_001261063 DDBJ / EMBL / GenBank • AA202888 AAF01457 AAF57780 AAL48895 AAM68473 AAM68474 AAN71648 AAO39594 AAS64814 ACL83150 AF188634 AGB93595 AI543738 AQ025967 AW941517 AW944651 AY071273 BI234680 BT001876 BT003591 CL526085 CL705882 CL943519 CZ466468 CZ472884 CZ472885 CZ473955 CZ475056 CZ475057 CZ476814 CZ477929 CZ477930 CZ479389 CZ479390 CZ484784 CZ485246 CZ485247 CZ486188 Entrez Gene - A searchable database of RefSeq genes. • 37040 UniProtKB/Swiss-Prot • Q9U6B8 UniProtKB/TrEMBL • B7YZJ7 E2QCH2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Calcium release-activated calcium channel protein (IPR012446) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD03241
Linkouts
	BioGRID - A database of protein and genetic interactions • 62725 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041585 DroID - A comprehensive database of gene and protein interactions. • FBgn0041585 DRSC - Results from RNAi screens. • FBgn0041585 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041585 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11430-RB;CG11430-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041585 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37040 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37040 modMine - Data generated by the modENCODE project. • FBgn0041585
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	BcDNA:LD03241   CG11430 (Bayraktaroglu, 2000.4.27, Molnar et al., 2006, Venkiteswaran and Hasan, 2009, Seinen et al., 2010) CRACM1 (Vig et al., 2006, Cuttell et al., 2008) dOrai (Feske et al., 2006, Gwack et al., 2007, Cuttell et al., 2008, Venkiteswaran and Hasan, 2009, Agrawal et al., 2010, Sadaf et al., 2012) dorai (Cuttell et al., 2008) dOrai1 (Venkiteswaran and Hasan, 2009) l(2)k11505 (Spradling et al., 1999, ) olf186-F (Robinson, 2006, Zhang et al., 2006, Feske et al., 2006, Perrimon and Mathey-Prevot, 2007, Molnar et al., 2006, Vig et al., 2006, Yeromin et al., 2006, Koizumi et al., 2007, Chorna et al., 2009, Cuttell et al., 2008, Venkiteswaran and Hasan, 2009, Adryan et al., 2007) Olf186-F (Nelson et al., 2005) Orai (Prakriya et al., 2006, Yeromin et al., 2006, Gwack et al., 2007, Penna et al., 2008, Venkiteswaran and Hasan, 2009, Agrawal et al., 2010, Cai, 2007) SPH206 (Ross et al., 2003)
Name Synonym	CRAC modulator 1 (Vig et al., 2006) lethal (2) k11505   olf186-F   Orai (Zhang et al., 2006)
Secondary FlyBase IDs
	FBgn0021911 FBgn0034280 FBgn0064926
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Sadaf et al., 2012, PLoS ONE 7(9): e46405 Synaptic Activity in Serotonergic Neurons Is Required for Air-Puff Stimulated Flight in Drosophila melanogaster. [FBrf0219558] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...