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Gene Dmel\dlp

General Information
Symbol	Dmel\dlp	Species	D. melanogaster
Name	dally-like	Annotation symbol	CG32146
Feature type	protein_coding_gene	FlyBase ID	FBgn0041604
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	dly
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	70E5-70E7	Sequence location	3L:14,625,720..14,664,716 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dally-like is referred to in FlyBase by the symbol Dmel\dlp (CG32146, FBgn0041604). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Wnt-protein binding. There is experimental evidence for 13 unique biological process terms, many of which group under: biological regulation; system development; cellular process; regionalization; positive regulation of response to stimulus; multicellular organismal development; positive regulation of signal transduction; cellular component organization or biogenesis; embryonic pattern specification; post-embryonic organ morphogenesis; sensory organ development; regulation of signal transduction; sensory perception of light stimulus. 58 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; thoracic segment; external compound sense organ; adult; acellular anatomical structure; imaginal precursor; embryonic/larval integumentary system; wing margin bristle; peripheral nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Glypican. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1636974_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of dlp. Gene sequence location is 3L:14625720..14664716.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Dejima et al., 2011, J. Biol. Chem. 286(19): 17103--17111 Sequence features HFA10472 BKN27351 HFA10281 BKN46137
FB2011_10	Controlled Vocabulary Terms neuromuscular junction Alleles dlp[Scer\UAS.cEa.T:Avic\GFP] dlp[unspecified] dlp[Deltagpi.Scer\UAS.T:Avic\GFP-CFP] dlp[Scer\UAS.T:Avic\GFP-YFP] References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Wojcinski et al., 2011, Dev. Biol. 358(1): 168--180 Transgenic Constructs P{UAS-YFP-dlp} P{UAS-GFP-dlp.Deltagpi} P{UAS-GFP-dlp.E}
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 70E5-70E7   Limits computationally determined from genome sequence between P{PZ}Mpcp00564 and P{PZ}l(3)rO220rO220
Experimentally Determined Cytological Location
Cytogenetic map Notes References 70F-70F     (Baeg, 2000.10.26) 70F-70F   (determined by in situ hybridisation)   (Baeg et al., 2001)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dlp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dlp-RA FBtr0075679  NM_079347   3749   765 dlp-RB FBtr0075680  NM_206353   4271   939
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dlp-PA   FBpp0075431   85.3   765   5.59     NP_524071   AAF49722 dlp-PB   FBpp0089384   104.2   939   6.45     NP_996075   AAS65005
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments	Sdc protein and dlp protein show highly overlapping, yet distinct, patterns of endogenous expression in the developing CNS. (Johnson et al., 2004)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glypican (IPR001863)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142268   AA539700   AE014296 AAF49722   AE014296 AAS65005   AF317090 AAG38110   AI515580   AW943905   AY052017 AAK93441   BG638149   BG638155   BI162649   BI164172   BI166200   BI168573   BI169507   BI169840   BI171364   BI172035   BI172055   BI173318   BI228464   BI232612   BI233132   BI234393   BI236704   BI236709   BI238597   BI241094   BI241725   BI243381   BI366405   BI366936   BI372864   BI373031   BI373280   BI374995   BI375355   BI375697   BI484630   BI485244   BI485726   BI487208   BI577497   BI579634   CO177263   CO179219   CO185916   CO189614   CO189656   CO194712   CO195871   CO266684   CO270040   CO270044   CO272124   CO279829   CO293781   CO295190   CO295781   CO297510   CO304778   CO305690   CO306343   CO308855   CO309687   CO328614   CO340492   CO341356   CO342466   CZ468260   CZ468991   CZ469120   CZ469176   CZ477294   CZ479638   CZ486116   CZ486117   CZ488369   DN154335   EC053034   EC057870   EC061594   EC071278   EC072289   EC075927   EC077728   EC087904   EC194702   EC195676   EC197849   EC199868   EC201975   EC206876   EC214775   EC224555   EC224678   EC229858   EC231775   EC237835   EC243194   EC243416   EC255956   EC257054   EC258369   GH944290   GH947669   GH960065   GH960855   GH966489   GH968394   GH970319   GH972085   GH977383   GH983496   GH984433
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KUL1 Q9GPL5 Q9VUG1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 2   organism | ubiquitous   (Baeg et al., 2001) embryonic stage 5   organism | faint & ubiquitous   (Khare and Baumgartner, 2000) embryonic stage 6   organism | striped   (Khare and Baumgartner, 2000) Comment:2 anterior and 2 posterior stripes embryonic stage 7 -- 10   procephalic neurogenic region   (Khare and Baumgartner, 2000) embryonic stage 8   organism | segmentally repeated   (Baeg et al., 2001) embryonic stage 10 -- 11   organism | striped   (Khare and Baumgartner, 2000) Comment:15 stripes clypeo-labral primordium | anterior   (Khare and Baumgartner, 2000) gnathal primordium | anterior   (Khare and Baumgartner, 2000) embryonic stage 13   embryonic/larval midgut primordium   (Khare and Baumgartner, 2000) embryonic hindgut   (Khare and Baumgartner, 2000) presumptive embryonic/larval central nervous system | faint   (Khare and Baumgartner, 2000) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17   organism   (Khare and Baumgartner, 2000) Comment:assayed 0-18 hr AEL pupal stage -- adult stage   organism   (Khare and Baumgartner, 2000) Comment:not detected in third instar larvae
Additional Descriptive Data
	dlp transcript is ubiquitously but weakly expressed at embryonic stage 5. The pattern resolves into two strong anterior bands and two weak posterior bands by embryonic stage 6. The posterior bands fade by embryonic stage 7, while the anterior bands intensify in the procephalic neurogenic region. During germ band extension, dlp transcript is expressed in a pattern similar to that of wg at the same stage. Expression is observed in a pattern of fifteen stripes, in the procephalic neurogenic regions, at the anterior-most edge of the clypeo-labral primordium, and in the gnathal primordium. Double-labeling with en antibody reveals dlp expression overlaps both wg-expressing cells and wg target cells. At stage 13, dlp is expressed in the lining of the midgut, in the hindgut, and faintly in the central nervous system. (Khare and Baumgartner, 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16   presumptive embryonic/larval central nervous system & motor neuron   • axon (Johnson et al., 2004) lateral longitudinal fascicle & medial longitudinal fascicle   • axon (Johnson et al., 2004) commissure & fascicle   • cell surface of axon (Johnson et al., 2004)
Additional Descriptive Data
	also expressed at muscle insertions sites of embryonic CNS in stage 16 embryos (Johnson et al., 2004)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041604    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041604 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041604 expression level Developmental Stage   Expression Level embryo 00-02hr    3151 embryo 02-04hr    3612 embryo 04-06hr    4071 embryo 06-08hr    5116 embryo 08-10hr    4508 embryo 10-12hr    3372 embryo 12-14hr    4074 embryo 14-16hr    3870 embryo 16-18hr    2603 embryo 18-20hr    1416 embryo 20-22hr    1906 embryo 22-24hr    2012 larva L1    720 larva L2    547 larva L3 12hr old    564 larva L3 puffstage 1-2    557 larva L3 puffstage 3-6    1094 larva L3 puffstage 7-9    1614 white prepupae new    2187 white prepupae 12hr    1946 white prepupae 24hr    2883 pupae 2d postWPP    1713 pupae 3d postWPP    632 pupae 4d postWPP    358 adult male 01day    413 adult male 05day    436 adult male 30day    380 adult female 01day    1100 adult female 05day    1888 adult female 30day    1850 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3151) embryo 02-04hr  (3612) embryo 04-06hr  (4071) embryo 06-08hr  (5116) embryo 08-10hr  (4508) embryo 10-12hr  (3372) embryo 12-14hr  (4074) embryo 14-16hr  (3870) embryo 16-18hr  (2603) embryo 18-20hr  (1416) embryo 20-22hr  (1906) embryo 22-24hr  (2012) larva L1  (720) larva L2  (547) larva L3 12hr old  (564) larva L3 puffstage 1-2  (557) larva L3 puffstage 3-6  (1094) larva L3 puffstage 7-9  (1614) white prepupae new  (2187) white prepupae 12hr  (1946) white prepupae 24hr  (2883) pupae 2d postWPP  (1713) pupae 3d postWPP  (632) pupae 4d postWPP  (358) adult male 01day  (413) adult male 05day  (436) adult male 30day  (380) adult female 01day  (1100) adult female 05day  (1888) adult female 30day  (1850) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3151) embryo 02-04hr  (3612) embryo 04-06hr  (4071) embryo 06-08hr  (5116) embryo 08-10hr  (4508) embryo 10-12hr  (3372) embryo 12-14hr  (4074) embryo 14-16hr  (3870) embryo 16-18hr  (2603) embryo 18-20hr  1416 embryo 20-22hr  (1906) embryo 22-24hr  (2012) larva L1    720 larva L2    547 larva L3 12hr old    564 larva L3 puffstage 1-2    557 larva L3 puffstage 3-6    1094 larva L3 puffstage 7-9  (1614) white prepupae new  (2187) white prepupae 12hr  (1946) white prepupae 24hr  (2883) pupae 2d postWPP  (1713) pupae 3d postWPP    632 pupae 4d postWPP    358 adult male 01day    413 adult male 05day    436 adult male 30day    380 adult female 01day    1100 adult female 05day  (1888) adult female 30day  (1850) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3151 embryo 02-04hr    3612 embryo 04-06hr    4071 embryo 06-08hr    5116 embryo 08-10hr    4508 embryo 10-12hr    3372 embryo 12-14hr    4074 embryo 14-16hr    3870 embryo 16-18hr    2603 embryo 18-20hr    1416 embryo 20-22hr    1906 embryo 22-24hr    2012 larva L1    720 larva L2    547 larva L3 12hr old    564 larva L3 puffstage 1-2    557 larva L3 puffstage 3-6    1094 larva L3 puffstage 7-9    1614 white prepupae new    2187 white prepupae 12hr    1946 white prepupae 24hr    2883 pupae 2d postWPP    1713 pupae 3d postWPP    632 pupae 4d postWPP    358 adult male 01day    413 adult male 05day    436 adult male 30day    380 adult female 01day    1100 adult female 05day    1888 adult female 30day    1850 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3151 embryo 02-04hr    3612 embryo 04-06hr    4071 embryo 06-08hr    5116 embryo 08-10hr    4508 embryo 10-12hr    3372 embryo 12-14hr    4074 embryo 14-16hr    3870 embryo 16-18hr    2603 embryo 18-20hr    1416 embryo 20-22hr    1906 embryo 22-24hr    2012 larva L1    720 larva L2    547 larva L3 12hr old    564 larva L3 puffstage 1-2    557 larva L3 puffstage 3-6    1094 larva L3 puffstage 7-9    1614 white prepupae new    2187 white prepupae 12hr    1946 white prepupae 24hr    2883 pupae 2d postWPP    1713 pupae 3d postWPP    632 pupae 4d postWPP    358 adult male 01day    413 adult male 05day    436 adult male 30day    380 adult female 01day    1100 adult female 05day    1888 adult female 30day    1850 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041604 expression level Developmental Stage   Expression Level embryo 00-02hr    3151 embryo 02-04hr    3612 embryo 04-06hr    4071 embryo 06-08hr    5116 embryo 08-10hr    4508 embryo 10-12hr    3372 embryo 12-14hr    4074 embryo 14-16hr    3870 embryo 16-18hr    2603 embryo 18-20hr    1416 embryo 20-22hr    1906 embryo 22-24hr    2012 larva L1    720 larva L2    547 larva L3 12hr old    564 larva L3 puffstage 1-2    557 larva L3 puffstage 3-6    1094 larva L3 puffstage 7-9    1614 white prepupae new    2187 white prepupae 12hr    1946 white prepupae 24hr    2883 pupae 2d postWPP    1713 pupae 3d postWPP    632 pupae 4d postWPP    358 adult male 01day    413 adult male 05day    436 adult male 30day    380 adult female 01day    1100 adult female 05day    1888 adult female 30day    1850 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3151) embryo 02-04hr  (3612) embryo 04-06hr  (4071) embryo 06-08hr  (5116) embryo 08-10hr  (4508) embryo 10-12hr  (3372) embryo 12-14hr  (4074) embryo 14-16hr  (3870) embryo 16-18hr  (2603) embryo 18-20hr  (1416) embryo 20-22hr  (1906) embryo 22-24hr  (2012) larva L1  (720) larva L2  (547) larva L3 12hr old  (564) larva L3 puffstage 1-2  (557) larva L3 puffstage 3-6  (1094) larva L3 puffstage 7-9  (1614) white prepupae new  (2187) white prepupae 12hr  (1946) white prepupae 24hr  (2883) pupae 2d postWPP  (1713) pupae 3d postWPP  (632) pupae 4d postWPP  (358) adult male 01day  (413) adult male 05day  (436) adult male 30day  (380) adult female 01day  (1100) adult female 05day  (1888) adult female 30day  (1850) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3151) embryo 02-04hr  (3612) embryo 04-06hr  (4071) embryo 06-08hr  (5116) embryo 08-10hr  (4508) embryo 10-12hr  (3372) embryo 12-14hr  (4074) embryo 14-16hr  (3870) embryo 16-18hr  (2603) embryo 18-20hr  1416 embryo 20-22hr  1906 embryo 22-24hr  2012 larva L1    720 larva L2    547 larva L3 12hr old    564 larva L3 puffstage 1-2    557 larva L3 puffstage 3-6    1094 larva L3 puffstage 7-9  1614 white prepupae new  2187 white prepupae 12hr  1946 white prepupae 24hr  (2883) pupae 2d postWPP  1713 pupae 3d postWPP    632 pupae 4d postWPP    358 adult male 01day    413 adult male 05day    436 adult male 30day    380 adult female 01day    1100 adult female 05day  1888 adult female 30day  1850 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3151 embryo 02-04hr    3612 embryo 04-06hr    4071 embryo 06-08hr    5116 embryo 08-10hr    4508 embryo 10-12hr    3372 embryo 12-14hr    4074 embryo 14-16hr    3870 embryo 16-18hr    2603 embryo 18-20hr    1416 embryo 20-22hr    1906 embryo 22-24hr    2012 larva L1    720 larva L2    547 larva L3 12hr old    564 larva L3 puffstage 1-2    557 larva L3 puffstage 3-6    1094 larva L3 puffstage 7-9    1614 white prepupae new    2187 white prepupae 12hr    1946 white prepupae 24hr    2883 pupae 2d postWPP    1713 pupae 3d postWPP    632 pupae 4d postWPP    358 adult male 01day    413 adult male 05day    436 adult male 30day    380 adult female 01day    1100 adult female 05day    1888 adult female 30day    1850 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3151 embryo 02-04hr    3612 embryo 04-06hr    4071 embryo 06-08hr    5116 embryo 08-10hr    4508 embryo 10-12hr    3372 embryo 12-14hr    4074 embryo 14-16hr    3870 embryo 16-18hr    2603 embryo 18-20hr    1416 embryo 20-22hr    1906 embryo 22-24hr    2012 larva L1    720 larva L2    547 larva L3 12hr old    564 larva L3 puffstage 1-2    557 larva L3 puffstage 3-6    1094 larva L3 puffstage 7-9    1614 white prepupae new    2187 white prepupae 12hr    1946 white prepupae 24hr    2883 pupae 2d postWPP    1713 pupae 3d postWPP    632 pupae 4d postWPP    358 adult male 01day    413 adult male 05day    436 adult male 30day    380 adult female 01day    1100 adult female 05day    1888 adult female 30day    1850 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041604    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041604 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041604 expression level Tissue   Expression Level Larval Central Nervous System    319.575 Larval Midgut    176.8 Larval Hindgut    479.6 Larval Malpighian Tubules    284.5 Larval Fat Body no informative data Larval Salivary Gland    83.7 Larval Trachea    650.55 Larval Carcass    122.05 Adult Head    143.1 Adult Eye    408.475 Adult Brain    79.6 Adult Thoracic-Abdominal Ganglion    79.1 Adult Crop    373 Adult Midgut    105.8 Adult Hindgut    369.4 Adult Malpighian Tubules    69.3 Adult Fat Body    21.8 Adult Salivary Gland    58.4 Adult Heart    24.425 Adult VirginFemale Spermatheca    68.5 Adult InseminatedFemale Spermatheca    81.1 Adult Ovary    304 Adult Testis    43.2 Adult Male Accessory Gland    31.4 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    319.575 Larval Midgut    176.8 Larval Hindgut    479.6 Larval Malpighian Tubules    284.5 Larval Fat Body no informative data Larval Salivary Gland    83.7 Larval Trachea  (650.55) Larval Carcass    122.05 Adult Head    143.1 Adult Eye    408.475 Adult Brain    79.6 Adult Thoracic-Abdominal Ganglion    79.1 Adult Crop    373 Adult Midgut    105.8 Adult Hindgut    369.4 Adult Malpighian Tubules    69.3 Adult Fat Body    21.8 Adult Salivary Gland    58.4 Adult Heart    24.425 Adult VirginFemale Spermatheca    68.5 Adult InseminatedFemale Spermatheca    81.1 Adult Ovary    304 Adult Testis    43.2 Adult Male Accessory Gland    31.4 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    319.575 Larval Midgut    176.8 Larval Hindgut    479.6 Larval Malpighian Tubules    284.5 Larval Fat Body no informative data Larval Salivary Gland    83.7 Larval Trachea    650.55 Larval Carcass    122.05 Adult Head    143.1 Adult Eye    408.475 Adult Brain    79.6 Adult Thoracic-Abdominal Ganglion    79.1 Adult Crop    373 Adult Midgut    105.8 Adult Hindgut    369.4 Adult Malpighian Tubules    69.3 Adult Fat Body    21.8 Adult Salivary Gland    58.4 Adult Heart    24.425 Adult VirginFemale Spermatheca    68.5 Adult InseminatedFemale Spermatheca    81.1 Adult Ovary    304 Adult Testis    43.2 Adult Male Accessory Gland    31.4 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    319.575 Larval Midgut    176.8 Larval Hindgut    479.6 Larval Malpighian Tubules    284.5 Larval Fat Body no informative data Larval Salivary Gland    83.7 Larval Trachea    650.55 Larval Carcass    122.05 Adult Head    143.1 Adult Eye    408.475 Adult Brain    79.6 Adult Thoracic-Abdominal Ganglion    79.1 Adult Crop    373 Adult Midgut    105.8 Adult Hindgut    369.4 Adult Malpighian Tubules    69.3 Adult Fat Body    21.8 Adult Salivary Gland    58.4 Adult Heart    24.425 Adult VirginFemale Spermatheca    68.5 Adult InseminatedFemale Spermatheca    81.1 Adult Ovary    304 Adult Testis    43.2 Adult Male Accessory Gland    31.4 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041604 expression level Tissue   Expression Level Larval Central Nervous System    319.575 Larval Midgut    176.8 Larval Hindgut    479.6 Larval Malpighian Tubules    284.5 Larval Fat Body no informative data Larval Salivary Gland    83.7 Larval Trachea    650.55 Larval Carcass    122.05 Adult Head    143.1 Adult Eye    408.475 Adult Brain    79.6 Adult Thoracic-Abdominal Ganglion    79.1 Adult Crop    373 Adult Midgut    105.8 Adult Hindgut    369.4 Adult Malpighian Tubules    69.3 Adult Fat Body    21.8 Adult Salivary Gland    58.4 Adult Heart    24.425 Adult VirginFemale Spermatheca    68.5 Adult InseminatedFemale Spermatheca    81.1 Adult Ovary    304 Adult Testis    43.2 Adult Male Accessory Gland    31.4 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    319.575 Larval Midgut    176.8 Larval Hindgut    479.6 Larval Malpighian Tubules    284.5 Larval Fat Body no informative data Larval Salivary Gland    83.7 Larval Trachea  650.55 Larval Carcass    122.05 Adult Head    143.1 Adult Eye    408.475 Adult Brain    79.6 Adult Thoracic-Abdominal Ganglion    79.1 Adult Crop    373 Adult Midgut    105.8 Adult Hindgut    369.4 Adult Malpighian Tubules    69.3 Adult Fat Body    21.8 Adult Salivary Gland    58.4 Adult Heart    24.425 Adult VirginFemale Spermatheca    68.5 Adult InseminatedFemale Spermatheca    81.1 Adult Ovary    304 Adult Testis    43.2 Adult Male Accessory Gland    31.4 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    319.575 Larval Midgut    176.8 Larval Hindgut    479.6 Larval Malpighian Tubules    284.5 Larval Fat Body no informative data Larval Salivary Gland    83.7 Larval Trachea    650.55 Larval Carcass    122.05 Adult Head    143.1 Adult Eye    408.475 Adult Brain    79.6 Adult Thoracic-Abdominal Ganglion    79.1 Adult Crop    373 Adult Midgut    105.8 Adult Hindgut    369.4 Adult Malpighian Tubules    69.3 Adult Fat Body    21.8 Adult Salivary Gland    58.4 Adult Heart    24.425 Adult VirginFemale Spermatheca    68.5 Adult InseminatedFemale Spermatheca    81.1 Adult Ovary    304 Adult Testis    43.2 Adult Male Accessory Gland    31.4 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    319.575 Larval Midgut    176.8 Larval Hindgut    479.6 Larval Malpighian Tubules    284.5 Larval Fat Body no informative data Larval Salivary Gland    83.7 Larval Trachea    650.55 Larval Carcass    122.05 Adult Head    143.1 Adult Eye    408.475 Adult Brain    79.6 Adult Thoracic-Abdominal Ganglion    79.1 Adult Crop    373 Adult Midgut    105.8 Adult Hindgut    369.4 Adult Malpighian Tubules    69.3 Adult Fat Body    21.8 Adult Salivary Gland    58.4 Adult Heart    24.425 Adult VirginFemale Spermatheca    68.5 Adult InseminatedFemale Spermatheca    81.1 Adult Ovary    304 Adult Testis    43.2 Adult Male Accessory Gland    31.4 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    143.1   NA  Eye    408.475   NA  Brain    79.6   319.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    79.1   NA  Crop    373   176.8  Midgut    105.8   479.6  Hindgut    369.4   284.5  Malpighian Tubules    69.3   no informative data  Fat Body    21.8   83.7  Salivary Gland    58.4   NA  Heart    24.425   650.55  Trachea    NA   NA  VirginFemale Spermatheca    68.5   NA  InseminatedFemale Spermatheca    81.1   NA  Ovary    304   NA  Testis    43.2   NA  Male Accessory Gland    31.4   122.05  Carcass    31.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041604 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32146-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for dlp Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | non-rescuable maternal effect | segment polarity expression pattern dlpA187 lethal | larval stage dlpA187 lethal | pharate adult stage, with Scer\GAL4ptc-559.1 dlpScer\UAS.cBa lethal | recessive dlpMH20 semi-lethal dlp1 dlp2 semi-lethal (with Df(3L)fz-D21) dlp1 dlp2 viable dlpPL00308 dlpPL00325 dlpPL00424 viable, with Scer\GAL4pnr-MD237 dlpGD3592 Sterility Allele fertile dlpPL00308 dlpPL00325 dlpPL00424 Other Phenotypes Allele neuroanatomy defective (with Df(3L)fz-D21) dlp1 neuroanatomy defective (with dlp1) dlp2 neuroanatomy defective (with dlp2) dlp1 neurophysiology defective (with Df(3L)fz-D21) dlp1 visible dlpunspecified visible, with Scer\GAL4A9 dlpScer\UAS.T:Ivir\HA1 visible, with Scer\GAL4bbg-C96 dlpScer\UAS.cBa visible, with Scer\GAL4en-e16E dlpScer\UAS.cBa dlpScer\UAS.T:Avic\GFP,T:Rnor\CD2 dlpScer\UAS.T:Avic\GFP dlpScer\UAS.T:wg,T:Avic\GFP visible, with Scer\GAL4hh.PU dlpScer\UAS.T:wg,T:Avic\GFP visible, with Scer\GAL4pnr-MD237 dlpGD3592 visible, with Scer\GAL4salm-459.2 dlpScer\UAS.T:Ivir\HA1 Phenotype manifest in Allele 1st posterior cell dlpunspecified dlpMH20 1st posterior cell, with Scer\GAL4hh.PU dlpScer\UAS.T:wg,T:Avic\GFP chaeta | supernumerary, with Scer\GAL4pnr-MD237 dlpGD3592 denticle | ectopic dlpdsRNA.3' dlpdsRNA.5' denticle | ectopic | ventral (with dlp1) dlp2 denticle | ectopic | ventral (with dlp2) dlp1 denticle belt dlpMH20 embryonic/first instar larval cuticle dlpA187 dlpMH20 embryonic/first instar larval cuticle, with dlpa.cBa dlpcBa embryonic/first instar larval cuticle, with dlpcBa dlpa.cBa embryonic/first instar larval cuticle | segment polarity expression pattern dlpdsRNA.3' dlpdsRNA.5' embryonic/first instar larval cuticle | segment polarity expression pattern (with dlp1) dlp2 embryonic/first instar larval cuticle | segment polarity expression pattern (with dlp2) dlp1 eye dlpMH20 eye (with Df(3L)fz-D21) dlp1 eye photoreceptor cell & axon (with Df(3L)fz-D21) dlp1 eye photoreceptor cell & axon (with dlp1) dlp2 eye photoreceptor cell & axon (with dlp2) dlp1 interommatidial bristle (with Df(3L)fz-D21) dlp1 lamina plexus (with Df(3L)fz-D21) dlp1 lamina plexus (with dlp1) dlp2 lamina plexus (with dlp2) dlp1 medulla (with Df(3L)fz-D21) dlp1 medulla (with dlp1) dlp2 medulla (with dlp2) dlp1 ommatidium (with Df(3L)fz-D21) dlp1 sensory mother cell | somatic clone dlpA187 wing dlpMH20 wing, with Scer\GAL4A9 dlpScer\UAS.T:Ivir\HA1 wing, with Scer\GAL4en-e16E dlpScer\UAS.T:Avic\GFP dlpScer\UAS.T:wg,T:Avic\GFP dlpScer\UAS.cBa dlpScer\UAS.cMa.T:Avic\GFP dlpScer\UAS.T:Avic\GFP,T:Rnor\CD2 wing, with Scer\GAL4salm-459.2 dlpScer\UAS.T:Ivir\HA1 wing disc (with Df(3L)fz-D21) dlp1 wing margin, with Scer\GAL4A9 dlpScer\UAS.T:Ivir\HA1 wing margin, with Scer\GAL4bbg-C96 dlpScer\UAS.cBa wing margin, with Scer\GAL4dpp.blk1 dlpScer\UAS.T:Ivir\HA1 wing margin, with Scer\GAL4en-e16E dlpScer\UAS.T:Ivir\HA1 wing margin | posterior, with Scer\GAL4en-e16E dlpScer\UAS.T:Ivir\HA1 wing margin bristle, with Scer\GAL4ap-md544, dlp1 dlpScer\UAS.cBa wing margin bristle, with Scer\GAL4ap-md544, dlpScer\UAS.cBa dlp1 wing margin bristle | cell non-autonomous | ectopic | somatic clone, with Scer\GAL4αTub84B.PP dlpScer\UAS.T:Ivir\HA1 wing margin bristle | ectopic dlpMH20 wing margin bristle | ectopic (with Df(3L)fz-D21) dlp1 wing margin bristle | ectopic (with dlp1) dlp2 wing margin bristle | ectopic (with dlp2) dlp1 wing margin bristle | posterior, with Scer\GAL4en-e16E dlpScer\UAS.T:Ivir\HA1 wing margin bristle | supernumerary dlpMH20 wing margin bristle | supernumerary, with Scer\GAL4sd-SG29.1 dlpdsRNA.Sym.Scer\UAS wing sensillum, with Scer\GAL4bbg-C96 dlpScer\UAS.cBa
Classical Alleles ( 21 )
For All Classical Alleles Show
Allele of dlp Class Mutagen Stocks Known lesion dlpB313 1 -- dlpc02851 piggyBac transposase 1 -- dlpd10506 P-element activity 1 -- dlpe01816 piggyBac transposase 1 -- dlpf03537 piggyBac transposase 1 -- dlpf05743 piggyBac transposase 1 -- dlpPL00308 P-element activity 1 -- dlpPL00325 P-element activity 1 -- dlpPL00424 P-element activity 1 -- dlpMH20 amorphic allele - genetic evidence P-element activity 0 Yes dlp1 loss of function allele Delta2-3 0 Yes dlp2 loss of function allele ethyl methanesulfonate 0 -- dlpA187 loss of function allele ethyl methanesulfonate 0 Yes dlpA203 0 Yes dlpc04110 piggyBac transposase 0 -- dlpc04266 piggyBac transposase 0 -- dlpc04324 piggyBac transposase 0 -- dlpCPTI000445 piggyBac transposase 0 Yes dlpCPTI001218 piggyBac transposase 0 Yes dlpex15 Delta2-3 0 Yes dlpunspecified 0 --
Alleles Carried on Transgenic Constructs ( 37 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dlp Class Mutagen Stocks Known lesion dlpGD3592 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dlpHMS00875 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlpHMS00903 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlpKK107351 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlpScer\UAS.cBa in vitro construct - regulatory fusion 1 Yes dlp-HS.Scer\UAS.T:Avic\GFP-EGFP,T:Rnor\CD2 in vitro construct - coding region fusion 0 Yes dlp-HS.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes dlp-HS.Scer\UAS.T:Rnor\CD2 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dlp-HS.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes dlpa.cBa in vitro construct - RNAi 0 Yes dlpAct5C.PL in vitro construct - regulatory fusion 0 Yes dlpcBa in vitro construct - RNAi 0 Yes dlpdsRNA.3' in vitro construct - RNAi 0 Yes dlpdsRNA.5' in vitro construct - RNAi 0 Yes dlpdsRNA.5'UTR in vitro construct - RNAi 0 Yes dlpdsRNA.cBa in vitro construct - RNAi 0 Yes dlpdsRNA.cLa in vitro construct - RNAi 0 Yes dlpdsRNA.cNa in vitro construct - RNAi 0 Yes dlpdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes dlpdsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes dlpGPI.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlpMtnA.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes dlpN.Scer\UAS.T:Rnor\CD2 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlpScer\FRT.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlpScer\UAS.cEa.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlpScer\UAS.cMa.T:Avic\GFP FLPase 0 Yes dlpScer\UAS.T:Avic\GFP,T:Rnor\CD2 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlpScer\UAS.T:Avic\GFP-YFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlpScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion 0 Yes dlpScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlpScer\UAS.T:wg,T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlpVDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes dlpΔC.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes dlpΔGAG.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes dlpΔgpi.Scer\UAS.T:Avic\GFP-CFP in vitro construct - amino acid replacement in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlpΔGPI.Scer\UAS in vitro construct - regulatory fusion 0 Yes dlpΔN.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6124 (Ryder, 2004.4.26) Df(3L)fz-D21 (Kirkpatrick et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3592} NA P{KK107351} NA P{Sym-UAS-dlp} NA P{TRiP.HMS00875} NA P{TRiP.HMS00903} NA P{UAS(-FRT)dlp.GFP} NA P{UAS-dlp.dsRNA.M} NA P{UAS-dlp.GFP} NA P{UAS-dlp.HA} NA P{UAS-dlp.-HS.CD2} NA P{UAS-dlp.-HS.GFP.CD2} NA P{UAS-dlp.-HS.GFP} NA P{UAS-dlp.-HS} NA P{UAS-dlp.N-CD2} NA P{UAS-dlp.WT} NA P{UAS-dlp.ΔC} NA P{UAS-dlp.ΔGAG} NA P{UAS-dlp.ΔGPI} NA P{UAS-dlp.ΔN} NA P{UAS-GFP::dlp} NA P{UAS-GFP-dlp.E} NA P{UAS-GFP-dlp.Δgpi} NA P{UAS-GFP-dlp-CD2} NA P{UAS-GFP-GPI} NA P{UAS-YFP-dlp} NA characterization construct P{UAS-dlpN-fz2C} NA P{VDRC.dlp.U} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{GSV1}EP-1013EP-1013 NA P{XP}dlpd10506 NA miscellaneous insertions P{?PZ}dlp1 NA P{GT1}BG01388 NA PBac{5HPw+}dlpB313 NA PBac{602.P.SVS-1}dlpCPTI000445 NA PBac{681.P.FSVS-1}dlpCPTI001218 NA PBac{PB}dlpc02851 NA PBac{PB}dlpc04110 NA PBac{PB}dlpc04266 NA PBac{PB}dlpc04324 NA PBac{RB}dlpe01816 NA PBac{WH}dlpf03537 NA PBac{WH}dlpf05743 NA insertion of enhancer trap binary system PBac{GAL4D,EYFP}dlpPL00308 No PBac{GAL4D,EYFP}dlpPL00325 No PBac{GAL4D,EYFP}dlpPL00424 No insertion of enhancer trap P{PZ}Q5 No
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
Wnt-protein binding inferred from direct assay (Yan et al., 2009)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Rawson et al., 2005) compound eye development inferred from mutant phenotype (Kirkpatrick et al., 2004, Rawson, 2005) detection of light stimulus involved in visual perception inferred from mutant phenotype (Rawson et al., 2005) imaginal disc-derived wing margin morphogenesis inferred from mutant phenotype (Kirkpatrick et al., 2004) negative regulation of Wnt receptor signaling pathway inferred from mutant phenotype (Yan et al., 2009) positive regulation of smoothened signaling pathway inferred from mutant phenotype (Lum et al., 2003) positive regulation of Wnt receptor signaling pathway inferred from mutant phenotype (Yan et al., 2009) regulation of imaginal disc growth inferred from mutant phenotype (Hufnagel et al., 2007) regulation of smoothened signaling pathway inferred from mutant phenotype (Yan et al., 2010) segment polarity determination inferred from mutant phenotype (Desbordes and Sanson, 2003, Kirkpatrick et al., 2004) smoothened signaling pathway inferred from mutant phenotype (Desbordes and Sanson, 2003) wing disc dorsal/ventral pattern formation inferred from expression pattern AND inferred from genetic interaction with wg (Han et al., 2005) Wnt receptor signaling pathway inferred from genetic interaction with dally AND inferred from mutant phenotype (Baeg et al., 2001)
Cellular Component
CV term Evidence References
neuromuscular junction inferred from direct assay (Ren et al., 2009)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
heparan sulfate proteoglycan binding inferred from electronic annotation with InterPro:IPR001863 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
decapentaplegic signaling pathway non-traceable author statement (Lin et al., 2003) smoothened signaling pathway traceable author statement (Bussell, 2003) Wnt receptor signaling pathway traceable author statement (Nybakken and Perrimon, 2002, Bussell, 2003, Gonzalez-Gaitan, 2003)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity (Baeg et al., 2001) membrane inferred from electronic annotation with InterPro:IPR001863 (FlyBase Curators et al., 2004-) proteinaceous extracellular matrix inferred from electronic annotation with InterPro:IPR001863 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dlp allele Gene References dlpA187 dally (Han et al., 2004) dlpa.cBa dally (Baeg et al., 2001) dlpcBa dally (Baeg et al., 2001) dlpScer\UAS.cBa arm (Baeg et al., 2001) Sdc (Johnson et al., 2004) wg (Baeg et al., 2001) unspecified boi (Yao et al., 2006) ihog (Yao et al., 2006) Notum (Kirkpatrick et al., 2004) Sdc (Rawson et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64925 DroID - A comprehensive database of gene and protein interactions. • FBgn0041604 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39596
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24610 Dere\GG15689 Dgri\GH14753 Dmoj\GI11494 Dper\GL24494 Dpse\GA16712 Dsec\GM25472 Dsim\GD14495 Dvir\GJ13689 Dwil\GK10530 Dyak\GE22020
Curated drosophilid orthologs	Dpse\GA16712
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000433-PA Aedes aegypti (mosquito) AGAP003559-PA Anopheles gambiae (mosquito) XP_624719.1 Apis mellifera (honey bee) XP_001948900.1 Acyrthosiphon pisum (pea aphid) 59323 Branchiostoma floridae (lancelet) 70952 Branchiostoma floridae (lancelet) BGIBMGA003304-PA Bombyx mori (silk worm) ENSBTAP00000027510 Bos taurus (bovine) CN24917 Caenorhabditis brenneri (small nematode) CE26816 Caenorhabditis elegans (worm) ENSCAFP00000027820 Canis familiaris (dog) ENSCINP00000027821 Ciona intestinalis (sea squirt) CPIJ007485 Culex pipens (mosquito) ENSCPOP00000001227 Cavia porcellus (guinea pig) RP06520 Caenorhabditis remanei (nematode) 32704 Capitella spl (polychaete worm) 318151 Daphnia pulex (daphnia) ENSDARP00000019171 Danio rerio (zebra fish) ENSECAP00000003535 Equus caballus (horse) ENSGACP00000020271 Gymnopilus aculeatus (mushroom) ENSGALP00000027267 Gallus gallus (chicken) ENSP00000359864 Homo sapiens (human) 139272 Lottia gigantea (owl limpet) ENSMODP00000019101 Monodelphis domestica (gray opossum) ENSMMUP00000004602 Macaca mulatta (rhesus monkey) ENSMUSP00000110510 Mus musculus (house mouse) XP_001607767.1 Nasonia vitripennis (wasp) ENSOANP00000018532 Ornithorynchus anatinus (platypus) ENSORLP00000012321 Oryzias latipes (japanese killifish) PHUM008481-PA Pediculus humanus (human body louse) ENSPPYP00000019506 Pongo pygmaeus (orangutan) ENSPTRP00000038388 Pan troglodytes (chimpanzee) ENSRNOP00000003282 Rattus norvegicus (norway rat) Smp_105200.3 Schistosoma mansoni (trematode parasite) XP_001188778.1 Strongylocentrotus purpuratus (purple sea urchin) 61971 Trichoplax adhaerens (metazoa) XP_974946.2 Tribolium castaneum (red flour beetle) ENSTNIP00000012305 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011578 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000011898 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10898 LH23853 FBgn0239252 FBgn0212545 FBgn0200910 FBgn0186177 FBgn0180329 FBgn0250505 JGI_V11_318151 FBgn0076727 FBgn0162094 FBgn0162083 FBgn0157276 FBgn0154248 FBgn0134254 FBgn0122229 FBgn0107933 FBgn0101603 CPIJ007485 BGIBMGA003304 ACYPI008789 ACYPI004871 GB18773 GB11999 AGAP003559 AAEL000433 PB22259 PHUM310930 GLEAN_13355
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	9160 w1118; P{UAS-dlp.WT}3 34089 y1 sc* v1; P{TRiP.HMS00875}attP2 34091 y1 sc* v1; P{TRiP.HMS00903}attP2 16198 y1 w1118; PBac{5HPw+}dlpB313
Harvard	- P{XP}dlpd10506 - PBac{PB}dlpc02851 - PBac{RB}dlpe01816 - PBac{WH}dlpf03537 - PBac{WH}dlpf05743
VDRC	v100268 P{KK107351}VIE-260B v10299 w1118; P{GD3592}v10299 v10298 w1118; P{GD3592}v10298/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR11B23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 99 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47466
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD17840 RE01911 RE03784 RE06247 RE09366 RE10694 RE11126 RE13119 RE13958 RE13981 RE16218 RE26017 RE28709 RE29419 RE30085 RE32810 RE32815 RE35095 RE38109 RE38866 RE41002 RE51933 RE52577 RE60054 RE60243 RE60537 RE62695 RE63140 RE63561 RE67761 RE68542 RE69062 RE70728 RE71184 RE73696
Other clones	7838 28612 36500 52947 77912 79232 84325 97052 104640 144637 146633 156468 214443.54 214473.57 214565.53 CK01.52A.F6 CK01.55C.F9 CK01.55C.H7 CK01.65A.A2 CK01.127A.F11 CK01.127A.G11 CK01.127D.G8 CK01.147A.A10 CK00242 EC39091 EC42491 EC053034 EK014335 EK044723 EK044832 EK053033 EK058804 EK097224 EK097228 EK105934 EK136125 EK147226 EK169963 EK204809 EK208848 EK211557 EK218914 EK219252 EK246203 EK249244 EK250828 EK259522 EK291017 EP10746 EP12320 EP14950 LD18004 RP004197972 RP004208396 RP004208505 RP004243279 RP004292805 RP004402410 RP004428230 RP004455766 RP004479536 RP004540721 RP004549372
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041604 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39596
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dally-like CG5031 (FlyBase, 1996-)
Source for database merge of	Source for merge of: dlp CG17703 (Misra, 2001.8.10)
Additional comments	Annotations CG17703, CG5031 merged as CG32146 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for identity of dally-like CG5031 was sequence comparison (date:001216). (FlyBase, 1996-)
Other Comments
	The dlp core protein can interact with wg protein, the glycosaminoglycan chains that are attached in the dlp heparan sulfate proteoglycan enhance this interaction. (Yan et al., 2009) dlp shows a biphasic response, repressing short-range wg signalling and activating long-range wg signaling, and this biphasic response is seen regardless of whether its glycosylphosphatidylinositol linkage to the membrane can be cleaved. Rather, the transition from signaling activator to repressor is determined by the relative expression levels of dlp and fz2. (Yan et al., 2009) dlp is required for hh signalling during embryogenesis, and, in combination with dally is required for hh protein movement during wing disc development. (Han et al., 2004) dlp cooperates with Notum to limit wg signalling. (Kirkpatrick et al., 2004) dally and dlp are dispensable for wg signalling in embryos. dlp is required for hh signalling in the embryo and is required downstream of hh processing and either upstream or at the level of the ptc receptor. (Desbordes and Sanson, 2003) dlp may play a role in the extracellular distribution of wg protein. (Baeg et al., 2001) Inhibition of dlp gene activity implicates a function for dlp in wg protein reception and overexpression of dlp leads to an accumulation of extracellular wg protein. (Baeg et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079347 NM_206353 RefSeq (Proteins) • NP_524071 NP_996075 DDBJ / EMBL / GenBank • AA142268 AAF49722 AAG38110 AAK93441 AAS65005 AF317090 AI515580 AW943905 AY052017 CZ468260 CZ468991 CZ469120 CZ469176 CZ477294 CZ479638 CZ486116 CZ486117 CZ488369 Entrez Gene - A searchable database of RefSeq genes. • 39596 UniProtKB/TrEMBL • Q7KUL1 Q9GPL5 Q9VUG1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glypican (IPR001863)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64925 DroID - A comprehensive database of gene and protein interactions. • FBgn0041604 DRSC - Results from RNAi screens. • FBgn0041604 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041604 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32146-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041604 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205643 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39596 InParanoid A subset of ortholog calls from InParanoid. • AAEL000433-PA Aedes aegypti (mosquito) AGAP003559-PA Anopheles gambiae (mosquito) XP_624719.1 Apis mellifera (honey bee) XP_001948900.1 Acyrthosiphon pisum (pea aphid) 59323 Branchiostoma floridae (lancelet) 70952 Branchiostoma floridae (lancelet) BGIBMGA003304-PA Bombyx mori (silk worm) ENSBTAP00000027510 Bos taurus (bovine) CN24917 Caenorhabditis brenneri (small nematode) CE26816 Caenorhabditis elegans (worm) ENSCAFP00000027820 Canis familiaris (dog) ENSCINP00000027821 Ciona intestinalis (sea squirt) CPIJ007485 Culex pipens (mosquito) ENSCPOP00000001227 Cavia porcellus (guinea pig) RP06520 Caenorhabditis remanei (nematode) 32704 Capitella spl (polychaete worm) 318151 Daphnia pulex (daphnia) ENSDARP00000019171 Danio rerio (zebra fish) ENSECAP00000003535 Equus caballus (horse) ENSGACP00000020271 Gymnopilus aculeatus (mushroom) ENSGALP00000027267 Gallus gallus (chicken) ENSP00000359864 Homo sapiens (human) 139272 Lottia gigantea (owl limpet) ENSMODP00000019101 Monodelphis domestica (gray opossum) ENSMMUP00000004602 Macaca mulatta (rhesus monkey) ENSMUSP00000110510 Mus musculus (house mouse) XP_001607767.1 Nasonia vitripennis (wasp) ENSOANP00000018532 Ornithorynchus anatinus (platypus) ENSORLP00000012321 Oryzias latipes (japanese killifish) PHUM008481-PA Pediculus humanus (human body louse) ENSPPYP00000019506 Pongo pygmaeus (orangutan) ENSPTRP00000038388 Pan troglodytes (chimpanzee) ENSRNOP00000003282 Rattus norvegicus (norway rat) Smp_105200.3 Schistosoma mansoni (trematode parasite) XP_001188778.1 Strongylocentrotus purpuratus (purple sea urchin) 61971 Trichoplax adhaerens (metazoa) XP_974946.2 Tribolium castaneum (red flour beetle) ENSTNIP00000012305 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011578 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000011898 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39596 modMine - Data generated by the modENCODE project. • FBgn0041604 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10898 LH23853 FBgn0239252 FBgn0212545 FBgn0200910 FBgn0186177 FBgn0180329 FBgn0250505 JGI_V11_318151 FBgn0076727 FBgn0162094 FBgn0162083 FBgn0157276 FBgn0154248 FBgn0134254 FBgn0122229 FBgn0107933 FBgn0101603 CPIJ007485 BGIBMGA003304 ACYPI008789 ACYPI004871 GB18773 GB11999 AGAP003559 AAEL000433 PB22259 PHUM310930 GLEAN_13355
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG5031 (Molnar et al., 2006) CG17703   CG32146 (Metaxakis et al., 2005, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) CT16138 (Hynes and Zhao, 2000) Dally-like (Selva et al., 2001) D-gpcB (Selleck et al., 2000) Dlp (Guimond and Turnbull, 2004, Bussell, 2003, Giraldez et al., 2002, Kirkbride, 2005, McLellan et al., 2006, Gallet et al., 2007, Hufnagel et al., 2006, Wilson and Chuang, 2006, Hufnagel et al., 2007, Eugster et al., 2007, Serpe et al., 2008, Su et al., 2007) dlp (DasGupta et al., 2005, Kreuger et al., 2004, Briscoe and Therond, 2005, Gorfinkiel et al., 2005, Yao et al., 2006, de Navas et al., 2006, Williams et al., 2010, Nybakken et al., 2005, Szuperák et al., 2011, Baena-Lopez et al., 2009, Wendler et al., 2006, Yan and Lin, 2008, Williams et al., 2008, Molnar et al., 2006, Torroja et al., 2005, Gallet et al., 2008, Bornemann et al., 2008, Yan and Lin, 2007, Ren et al., 2009, Chanana et al., 2009, Yan et al., 2009, Baena-Lopez et al., 2008, Zeitlinger et al., 2007, Glise et al., 2005, Guo and Wang, 2009, Hayashi et al., 2009, DasGupta et al., 2007, Yan et al., 2009, Hermle et al., 2010, Vuilleumier et al., 2010, Yan et al., 2010, Kleinschmit et al., 2010, Liu et al., 2010, Wang et al., 2011, Hazelett et al., 2009, Wojcinski et al., 2011, Dejima et al., 2011) dly (Belenkaya et al., 2004, Princivalle and de Agostini, 2002, Han et al., 2004, Nakato and Kimata, 2002, Han et al., 2003, Lin et al., 2002, Waldrip et al., 2002, Baeg et al., 2001) Dly (Yan et al., 2004, Lin et al., 2003, Nybakken and Perrimon, 2002, Chanana et al., 2006)
Name Synonym	Dally-like (Eugster and Eaton, 2005, Hufnagel et al., 2006, Williams et al., 2008, Choo et al., 2011, Eugster et al., 2007, Gallet et al., 2008, Bornemann et al., 2008, Ren et al., 2009, Chanana et al., 2009, Yan et al., 2009, Guo and Wang, 2009, Yan et al., 2010, Liu et al., 2010, Baron et al., 2009) dally-like (Khare and Baumgartner, 2000, Baeg et al., 2001, Furlong, 2005, Baena-Lopez et al., 2009, Wendler et al., 2006, Yan and Lin, 2008, Torroja et al., 2005, Zeitouni et al., 2007, Yan and Lin, 2007, Yamashita et al., 2004, Hayashi et al., 2009, Hermle et al., 2010) Dallylike (Sexton and Harrison, 2008) Dally-like protein (Kirkbride, 2005) D-glypican B (Selleck et al., 2000)
Secondary FlyBase IDs
	FBgn0036434 FBgn0036435 FBgn0052146
References ( 140 )
Generate a list of	All references relating to this gene ( 140 )
List References by type	Research paper  ( 61 ) Supplementary material  ( 7 ) Review  ( 24 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 24 ) FlyBase analysis  ( 3 ) Meeting report  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Conference report  ( 1 ) Letter  ( 2 )
Recent research papers ( 11 )
	Choo et al., 2011, PLoS ONE 6(4): e14778 Genome-wide analysis of the binding of the hox protein ultrabithorax and the hox cofactor homothorax in Drosophila. [FBrf0213420] Dejima et al., 2011, J. Biol. Chem. 286(19): 17103--17111 Novel Contact-dependent Bone Morphogenetic Protein (BMP) Signaling Mediated by Heparan Sulfate Proteoglycans. [FBrf0213647] Szuperák et al., 2011, Development 138(4): 715--724 Feedback regulation of Drosophila BMP signaling by the novel extracellular protein Larval Translucida. [FBrf0212881] Wang et al., 2011, Infect. Immun. 79(2): 606--616 Host and Pathogen Glycosaminoglycan-Binding Proteins Modulate Antimicrobial Peptide Responses in Drosophila melanogaster. [FBrf0212806] Wojcinski et al., 2011, Dev. Biol. 358(1): 168--180 DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop. [FBrf0215253] Hermle et al., 2010, Curr. Biol. 20(14): 1269--1276 Regulation of Frizzled-Dependent Planar Polarity Signaling by a V-ATPase Subunit. [FBrf0211335] Kleinschmit et al., 2010, Dev. Biol. 345(2): 204--214 Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation. [FBrf0211640] Liu et al., 2010, Sci. Signal. 3(132): ra57 The Drosophila Female Germline Stem Cell Lineage Acts to Spatially Restrict DPP Function Within the Niche. [FBrf0211426] Vuilleumier et al., 2010, Nat. Cell Biol. 12(6): 611--617 Control of Dpp morphogen signalling by a secreted feedback regulator. [FBrf0210884] Williams et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(13): 5869--5874 Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. [FBrf0210451] Yan et al., 2010, Development 137(12): 2033--2044 The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. [FBrf0210906] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...