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Gene Dmel\Ku80

General Information
Symbol	Dmel\Ku80	Species	D. melanogaster
Name	Ku80	Annotation symbol	CG18801
Feature type	protein_coding_gene	FlyBase ID	FBgn0041627
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	BG:DS09217.6
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35D4-35D4	Sequence location	2L:15,768,512..15,771,280 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ku80 is referred to in FlyBase by the symbol Dmel\Ku80 (CG18801, FBgn0041627). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATP-dependent DNA helicase activity; single-stranded DNA-dependent ATP-dependent DNA helicase activity. There is experimental evidence that it is involved in the biological process: telomere maintenance. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA helicase, ATP-dependent, Ku type; DNA helicase, ATP-dependent, Ku80 subunit; Ku, C-terminal; Ku70/Ku80 C-terminal arm; Ku70/Ku80, N-terminal alpha/beta; Spen Paralogue and Orthologue SPOC, C-terminal-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1625759_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ku80. Gene sequence location is 2L:15768512..15771280.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Chiolo et al., 2011, Cell 144(5): 732--744 Sequence features HFA02699 BKN21449
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35D4-35D4   Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ku80 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ku80-RA FBtr0080763  NM_135923   2543   699
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ku80-PA   FBpp0080322   79.8   699   5.02     NP_609767   AAG22435
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ku70/Ku80, N-terminal alpha/beta (IPR005161) DNA helicase, ATP-dependent, Ku type (IPR006164) Ku70/Ku80 C-terminal arm (IPR005160) Ku, C-terminal (IPR014893) Spen Paralogue and Orthologue SPOC, C-terminal-like (IPR016194) DNA helicase, ATP-dependent, Ku80 subunit (IPR024193)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAG22435   AF237722 AAF63744   AY089401   AY118697 AAM50557   BF487785   BF497341   BF497749   BF498994   BF499865   BF503167   BG640251   BI357544   BI366538   BI370116   BI636422   GH750570   GH752656   GH772229   GH790543   GH791970   GH792840   GH797714   GH800731   GH806049   GH820042   GH820815   GH821550   GH839687   GH857489   GH858679   GH866524   GH868557   GH880966   GH880971   GH883801   GH887456   GH889089   GH902739   GH905510   GH907941   GH913965   GH914696   GH920180   GH926035   GH935402
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MSM8 Q9I7M8 Q9NGX6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041627    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041627 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041627 expression level Developmental Stage   Expression Level embryo 00-02hr    1324 embryo 02-04hr    506 embryo 04-06hr    931 embryo 06-08hr    634 embryo 08-10hr    478 embryo 10-12hr    277 embryo 12-14hr    117 embryo 14-16hr    120 embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1    151 larva L2    203 larva L3 12hr old    138 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    317 larva L3 puffstage 7-9    344 white prepupae new    366 white prepupae 12hr    531 white prepupae 24hr    675 pupae 2d postWPP    596 pupae 3d postWPP    316 pupae 4d postWPP    283 adult male 01day    392 adult male 05day    608 adult male 30day    576 adult female 01day    482 adult female 05day    987 adult female 30day    1009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1324) embryo 02-04hr  (506) embryo 04-06hr  (931) embryo 06-08hr  (634) embryo 08-10hr  (478) embryo 10-12hr  (277) embryo 12-14hr  (117) embryo 14-16hr  (120) embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1  (151) larva L2  (203) larva L3 12hr old  (138) larva L3 puffstage 1-2  (227) larva L3 puffstage 3-6  (317) larva L3 puffstage 7-9  (344) white prepupae new  (366) white prepupae 12hr  (531) white prepupae 24hr  (675) pupae 2d postWPP  (596) pupae 3d postWPP  (316) pupae 4d postWPP  (283) adult male 01day  (392) adult male 05day  (608) adult male 30day  (576) adult female 01day  (482) adult female 05day  (987) adult female 30day  (1009) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1324 embryo 02-04hr    506 embryo 04-06hr    931 embryo 06-08hr    634 embryo 08-10hr    478 embryo 10-12hr    277 embryo 12-14hr    117 embryo 14-16hr    120 embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1    151 larva L2    203 larva L3 12hr old    138 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    317 larva L3 puffstage 7-9    344 white prepupae new    366 white prepupae 12hr    531 white prepupae 24hr    675 pupae 2d postWPP    596 pupae 3d postWPP    316 pupae 4d postWPP    283 adult male 01day    392 adult male 05day    608 adult male 30day    576 adult female 01day    482 adult female 05day    987 adult female 30day    1009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1324 embryo 02-04hr    506 embryo 04-06hr    931 embryo 06-08hr    634 embryo 08-10hr    478 embryo 10-12hr    277 embryo 12-14hr    117 embryo 14-16hr    120 embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1    151 larva L2    203 larva L3 12hr old    138 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    317 larva L3 puffstage 7-9    344 white prepupae new    366 white prepupae 12hr    531 white prepupae 24hr    675 pupae 2d postWPP    596 pupae 3d postWPP    316 pupae 4d postWPP    283 adult male 01day    392 adult male 05day    608 adult male 30day    576 adult female 01day    482 adult female 05day    987 adult female 30day    1009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1324 embryo 02-04hr    506 embryo 04-06hr    931 embryo 06-08hr    634 embryo 08-10hr    478 embryo 10-12hr    277 embryo 12-14hr    117 embryo 14-16hr    120 embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1    151 larva L2    203 larva L3 12hr old    138 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    317 larva L3 puffstage 7-9    344 white prepupae new    366 white prepupae 12hr    531 white prepupae 24hr    675 pupae 2d postWPP    596 pupae 3d postWPP    316 pupae 4d postWPP    283 adult male 01day    392 adult male 05day    608 adult male 30day    576 adult female 01day    482 adult female 05day    987 adult female 30day    1009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041627 expression level Developmental Stage   Expression Level embryo 00-02hr    1324 embryo 02-04hr    506 embryo 04-06hr    931 embryo 06-08hr    634 embryo 08-10hr    478 embryo 10-12hr    277 embryo 12-14hr    117 embryo 14-16hr    120 embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1    151 larva L2    203 larva L3 12hr old    138 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    317 larva L3 puffstage 7-9    344 white prepupae new    366 white prepupae 12hr    531 white prepupae 24hr    675 pupae 2d postWPP    596 pupae 3d postWPP    316 pupae 4d postWPP    283 adult male 01day    392 adult male 05day    608 adult male 30day    576 adult female 01day    482 adult female 05day    987 adult female 30day    1009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1324) embryo 02-04hr  (506) embryo 04-06hr  (931) embryo 06-08hr  (634) embryo 08-10hr  (478) embryo 10-12hr  (277) embryo 12-14hr  117 embryo 14-16hr  120 embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1  (151) larva L2  (203) larva L3 12hr old  138 larva L3 puffstage 1-2  (227) larva L3 puffstage 3-6  (317) larva L3 puffstage 7-9  (344) white prepupae new  (366) white prepupae 12hr  (531) white prepupae 24hr  (675) pupae 2d postWPP  (596) pupae 3d postWPP  (316) pupae 4d postWPP  (283) adult male 01day  (392) adult male 05day  (608) adult male 30day  (576) adult female 01day  (482) adult female 05day  (987) adult female 30day  (1009) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1324 embryo 02-04hr    506 embryo 04-06hr    931 embryo 06-08hr    634 embryo 08-10hr    478 embryo 10-12hr    277 embryo 12-14hr    117 embryo 14-16hr    120 embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1    151 larva L2    203 larva L3 12hr old    138 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    317 larva L3 puffstage 7-9    344 white prepupae new    366 white prepupae 12hr    531 white prepupae 24hr    675 pupae 2d postWPP    596 pupae 3d postWPP    316 pupae 4d postWPP    283 adult male 01day    392 adult male 05day    608 adult male 30day    576 adult female 01day    482 adult female 05day    987 adult female 30day    1009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1324 embryo 02-04hr    506 embryo 04-06hr    931 embryo 06-08hr    634 embryo 08-10hr    478 embryo 10-12hr    277 embryo 12-14hr    117 embryo 14-16hr    120 embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1    151 larva L2    203 larva L3 12hr old    138 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    317 larva L3 puffstage 7-9    344 white prepupae new    366 white prepupae 12hr    531 white prepupae 24hr    675 pupae 2d postWPP    596 pupae 3d postWPP    316 pupae 4d postWPP    283 adult male 01day    392 adult male 05day    608 adult male 30day    576 adult female 01day    482 adult female 05day    987 adult female 30day    1009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1324 embryo 02-04hr    506 embryo 04-06hr    931 embryo 06-08hr    634 embryo 08-10hr    478 embryo 10-12hr    277 embryo 12-14hr    117 embryo 14-16hr    120 embryo 16-18hr    96 embryo 18-20hr    72 embryo 20-22hr    50 embryo 22-24hr    63 larva L1    151 larva L2    203 larva L3 12hr old    138 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    317 larva L3 puffstage 7-9    344 white prepupae new    366 white prepupae 12hr    531 white prepupae 24hr    675 pupae 2d postWPP    596 pupae 3d postWPP    316 pupae 4d postWPP    283 adult male 01day    392 adult male 05day    608 adult male 30day    576 adult female 01day    482 adult female 05day    987 adult female 30day    1009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041627    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041627 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041627 expression level Tissue   Expression Level Larval Central Nervous System    51.675 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    46 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    39.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.1 Adult Malpighian Tubules    49.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    68.9 Adult Testis    60.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    51.675 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    46 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    39.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.1 Adult Malpighian Tubules    49.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    68.9 Adult Testis    60.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    51.675 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    46 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    39.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.1 Adult Malpighian Tubules    49.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    68.9 Adult Testis    60.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    51.675 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    46 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    39.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.1 Adult Malpighian Tubules    49.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    68.9 Adult Testis    60.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041627 expression level Tissue   Expression Level Larval Central Nervous System    51.675 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    46 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    39.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.1 Adult Malpighian Tubules    49.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    68.9 Adult Testis    60.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    51.675 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    46 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    39.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.1 Adult Malpighian Tubules    49.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    68.9 Adult Testis    60.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    51.675 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    46 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    39.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.1 Adult Malpighian Tubules    49.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    68.9 Adult Testis    60.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    51.675 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    46 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    39.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.1 Adult Malpighian Tubules    49.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    68.9 Adult Testis    60.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    31.7   51.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    43.2   NA  Crop    no informative data   no informative data  Midgut    no informative data   no informative data  Hindgut    29.1   46  Malpighian Tubules    49.8   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    no informative data   39.9  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    68.9   NA  Testis    60.6   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041627 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18801-RA;CG31826-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Ku80GD1712 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Ku80 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ku80 Class Mutagen Stocks Known lesion Ku80GD1712 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ku80JF02790 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ku80dsRNA.cMa in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6037 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1712} NA P{TRiP.JF02790} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
telomere maintenance inferred from mutant phenotype (Melnikova et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP-dependent DNA helicase activity inferred from sequence or structural similarity (Ashburner et al., 1999) DNA binding inferred from electronic annotation with InterPro:IPR005160, InterPro:IPR006164, InterPro:IPR024193 (FlyBase Curators et al., 2004-) single-stranded DNA-dependent ATP-dependent DNA helicase activity inferred from sequence or structural similarity with UniProtKB:P27641 (FlyBase Genome Annotators, 2002-2003)
Biological Process
CV term Evidence References
DNA recombination inferred from electronic annotation with InterPro:IPR024193 (FlyBase Curators et al., 2004-) double-strand break repair via nonhomologous end joining inferred from electronic annotation with InterPro:IPR005160, InterPro:IPR006164, InterPro:IPR024193 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
DNA-dependent protein kinase-DNA ligase 4 complex inferred from electronic annotation with InterPro:IPR024193 (FlyBase Curators et al., 2004-) single-stranded DNA-dependent ATP-dependent DNA helicase complex inferred from sequence or structural similarity with UniProtKB:P27641 (FlyBase Genome Annotators, 2002-2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ku80 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60943 DroID - A comprehensive database of gene and protein interactions. • FBgn0041627 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34930
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14974 Dere\GG24193 Dgri\GH13494 Dmoj\GI17244 Dper\GL15436 Dpse\GA15084 Dsec\GM14187 Dsim\GD21940 Dvir\GJ18003 Dwil\GK24271 Dyak\GE19388
Curated drosophilid orthologs	Dpse\GA15084   Dsim\Ku80 (Anderson et al., 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003684-PA Aedes aegypti (mosquito) AGAP009910-PA Anopheles gambiae (mosquito) XP_001944675.1 Acyrthosiphon pisum (pea aphid) At1g48050.1 Arabidopsis thaliana (wall cress) 164247 Branchiostoma floridae (lancelet) XP_001902342.1 Brugia malayi (roundworm nematode) ENSCAFP00000021256 Canis familiaris (dog) JA10807 Caenorhabditis japonica (nematode) CPIJ011452 Culex pipens (mosquito) ENSCPOP00000010984 Cavia porcellus (guinea pig) 163248 Capitella spl (polychaete worm) DDB0232002 Dictyostelium discoideum (amoeba) ENSDARP00000090493 Danio rerio (zebra fish) ENSECAP00000014544 Equus caballus (horse) ENSGACP00000008149 Gymnopilus aculeatus (mushroom) ENSGALP00000018706 Gallus gallus (chicken) ENSP00000329528 Homo sapiens (human) ISCW017702-PA Ixodes scapularis (deer tick) KLLA0B12672g Kluyveromyces lactis (yeast) ENSMODP00000019417 Monodelphis domestica (gray opossum) ENSMUSP00000027379 Mus musculus (house mouse) ENSORLP00000020528 Oryzias latipes (japanese killifish) LOC_Os03g63920.1 Oryza sativa (asian rice) 188592 Physcomitrella patens (moss) ENSPPYP00000014697 Pongo pygmaeus (orangutan) 80333 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000022048 Pan troglodytes (chimpanzee) ENSRNOP00000021656 Rattus norvegicus (norway rat) Smp_083780 Schistosoma mansoni (trematode parasite) XP_788472.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000019563 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028511 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV30285 LH18130 ISCW017702 FBgn0236732 FBgn0226232 FBgn0205169 FBgn0193355 FBgn0169113 FBgn0075109 FBgn0153040 FBgn0139988 FBgn0120970 FBgn0116325 FBgn0091999 CPIJ011452 ACYPI41812 ACYPI001555 GB12351 AGAP009910 AAEL003684 PB25293 PHUM529370 GLEAN_13478
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	27710 y1 v1; P{TRiP.JF02790}attP2
VDRC	v37110 w1118; P{GD1712}v37110 v37111 w1118; P{GD1712}v37111
Genomic Clones ( 2 )
	BACR06K01 BACR44L22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 42 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT19081 AT22782
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11493 AT12025 AT13487 AT14637 AT22840 RE44058 RE52096 RE56523 SD11227 SD18104
Other clones	RP003022956 RP003056322 RP003071683 RP003089873 RP003099251 RP003099792 RP003108864 RP003135118 RP003149630 RP003209697 RP003211081 RP003226570 RP003231224 RP003237273 RP003242359 RP003248315 RP003294884 RP003382497 RP003413925 RP003425497 RP003472560 RP003495158 RP003509730 RP003512718 RP003518884 RP003525790 RP003537246 RP003553042 RP003595453 RP003639921
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041627 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34930
Antibody Information
	polyclonal (Chiolo et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Ku80 CG18801 (FlyBase, 1996-)
Additional comments	"BG:DS09217.4" and "BG:DS09217.6" probably correspond to "l(2)35De" and "l(2)35Dh", but the available data cannot determine which is which. (Ashburner et al., 1999) "BG:DS09217.6" could correspond to "l(2)35Di", "l(2)35De" or "l(2)35Dh". (Ashburner et al., 1999.10.12) Source for merge of Ku80 CG18801 was sequence comparison (date:001216). (FlyBase, 1996-)
Other Comments
	Ku80 has a role in length regulation of telomeres. (Melnikova et al., 2005) A decrease in Ku80 gene dosage causes a sharp increase in the frequency of HeT-A and TART-element attachments to a broken chromosome end and strongly enhances terminal DNA elongation by gene conversion. (Melnikova et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135923 RefSeq (Proteins) • NP_609767 DDBJ / EMBL / GenBank • AAF63744 AAG22435 AAM50557 AF237722 AY118697 BF503167 Entrez Gene - A searchable database of RefSeq genes. • 34930 UniProtKB/TrEMBL • Q8MSM8 Q9I7M8 Q9NGX6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ku70/Ku80, N-terminal alpha/beta (IPR005161) DNA helicase, ATP-dependent, Ku type (IPR006164) Ku70/Ku80 C-terminal arm (IPR005160) Ku, C-terminal (IPR014893) Spen Paralogue and Orthologue SPOC, C-terminal-like (IPR016194) DNA helicase, ATP-dependent, Ku80 subunit (IPR024193)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60943 DroID - A comprehensive database of gene and protein interactions. • FBgn0041627 DRSC - Results from RNAi screens. • FBgn0041627 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041627 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18801-RA;CG31826-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041627 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34930 InParanoid A subset of ortholog calls from InParanoid. • AAEL003684-PA Aedes aegypti (mosquito) AGAP009910-PA Anopheles gambiae (mosquito) XP_001944675.1 Acyrthosiphon pisum (pea aphid) At1g48050.1 Arabidopsis thaliana (wall cress) 164247 Branchiostoma floridae (lancelet) XP_001902342.1 Brugia malayi (roundworm nematode) ENSCAFP00000021256 Canis familiaris (dog) JA10807 Caenorhabditis japonica (nematode) CPIJ011452 Culex pipens (mosquito) ENSCPOP00000010984 Cavia porcellus (guinea pig) 163248 Capitella spl (polychaete worm) DDB0232002 Dictyostelium discoideum (amoeba) ENSDARP00000090493 Danio rerio (zebra fish) ENSECAP00000014544 Equus caballus (horse) ENSGACP00000008149 Gymnopilus aculeatus (mushroom) ENSGALP00000018706 Gallus gallus (chicken) ENSP00000329528 Homo sapiens (human) ISCW017702-PA Ixodes scapularis (deer tick) KLLA0B12672g Kluyveromyces lactis (yeast) ENSMODP00000019417 Monodelphis domestica (gray opossum) ENSMUSP00000027379 Mus musculus (house mouse) ENSORLP00000020528 Oryzias latipes (japanese killifish) LOC_Os03g63920.1 Oryza sativa (asian rice) 188592 Physcomitrella patens (moss) ENSPPYP00000014697 Pongo pygmaeus (orangutan) 80333 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000022048 Pan troglodytes (chimpanzee) ENSRNOP00000021656 Rattus norvegicus (norway rat) Smp_083780 Schistosoma mansoni (trematode parasite) XP_788472.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000019563 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028511 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34930 modMine - Data generated by the modENCODE project. • FBgn0041627 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV30285 LH18130 ISCW017702 FBgn0236732 FBgn0226232 FBgn0205169 FBgn0193355 FBgn0169113 FBgn0075109 FBgn0153040 FBgn0139988 FBgn0120970 FBgn0116325 FBgn0091999 CPIJ011452 ACYPI41812 ACYPI001555 GB12351 AGAP009910 AAEL003684 PB25293 PHUM529370 GLEAN_13478
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	BG:DS09217.6 (Ashburner et al., 1999.10.12, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999, ) CG18801 (Perkins et al., 2009) DmKu80 (Min et al., 2004) Ku (Boutanaev et al., 2007) KU80 (Mason et al., 2004) Ku80 (Chen, 2006, Mikhaylova et al., 2006, Cenci et al., 2005, Boutanaev et al., 2007, Brodsky et al., 2004, Gilchrist et al., 2008, Anderson et al., 2009, Akdemir et al., 2007, Reis et al., 2011) ku80 (Zhang et al., 2008)
Name Synonym	Ku80
Secondary FlyBase IDs
	FBgn0028843 FBgn0042128
References ( 34 )
Generate a list of	All references relating to this gene ( 34 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) Computer file  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 2 )
	Chiolo et al., 2011, Cell 144(5): 732--744 Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair. [FBrf0213146] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...