• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Hexo2

General Information
Symbol	Dmel\Hexo2	Species	D. melanogaster
Name	Hexosaminidase 2	Annotation symbol	CG1787
Feature type	protein_coding_gene	FlyBase ID	FBgn0041629
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	8A2-8A2	Sequence location	X:8,603,687..8,606,515 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Hexosaminidase 2 is referred to in FlyBase by the symbol Dmel\Hexo2 (CG1787, FBgn0041629). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: beta-N-acetylglucosaminidase activity. There is experimental evidence that it is involved in the biological process: negative regulation of growth of symbiont in host. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Acetylhexosaminidase, subunit a/b; Glycoside hydrolase, family 20; Glycoside hydrolase, family 20, catalytic core; Glycoside hydrolase, subgroup, catalytic domain; Glycoside hydrolase, superfamily. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, adult heart, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, larval trachea, adult female reproductive system, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1640957_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Hexo2. Gene sequence location is X:8603687..8606515.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features BKN27442 HFA18671
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 8A2-8A2   Limits computationally determined from genome sequence between P{EP}CG1632EP1583 and P{EP}MoeEP1652
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hexo2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hexo2-RA FBtr0071249  NM_080342   2142   622
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hexo2-PA   FBpp0071192   70.7   622   7.78     NP_525081   AAF46406
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 20 (IPR001540) Glycoside hydrolase, family 20, catalytic core (IPR015883) Glycoside hydrolase, subgroup, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853) Acetylhexosaminidase, subunit a/b (IPR015882)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698863   AA802171   AE014298 AAF46406   AI106932   AI133986   AI257448   AI292759   AI386556   AI404771   AI531344   AI533298   AI533971   AI542120   AI542141   AI542170   AI543306   AY118361 AAM48390   BG637234   BG637247   BG640254   BG640518   BI166855   BI167808   BI230983   BI563545   BI565337   BI565427   BI571529   BI581211   BI582726   BI583630   BI586202   BI587688   BI590705   BI592397   BI593376   BI593574   BI605681   BI606842   BI614474   BI614483   BI614601   BI614810   BI615722   BI616360   BI617228   BI619908   BI620048   BI621854   BI625507   BI626577   BI627455   BI632476   BI632765   BI634100   BI635088   BI636718   BI637098   BI640836   BI640855   CK135716   CK658829   CK660716   CO153407   CO274036   CO305656   CO316461   CO324519   CO327323   CO327757   CZ475381   CZ476399   CZ486657   CZ486658   EC226847   EC232562   EC235261   EC251995   EC255710   EC267282   EL871614
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W3C4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041629 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1787-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Hexo2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Hexo2f04129 viable, with Scer\GAL4pnr-MD237 Hexo2GD3287 Sterility Allele fertile Hexo2f04129 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Hexo2 Class Mutagen Stocks Known lesion Hexo2f04129 piggyBac transposase 2 -- Hexo2d06829 P-element activity 1 -- Hexo2d08764 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hexo2 Class Mutagen Stocks Known lesion Hexo2GD3287 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3287} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Hexo2f04129 NA insertion of mobile activating element P{XP}Hexo2d06829 NA P{XP}Hexo2d08764 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
beta-N-acetylglucosaminidase activity inferred from direct assay (Leonard et al., 2006)
Biological Process
CV term Evidence References
negative regulation of growth of symbiont in host inferred from mutant phenotype (Koo et al., 2008)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Cattaneo et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
beta-N-acetylhexosaminidase activity inferred from sequence or structural similarity with EMBL:U07631 (FlyBase, 1992-) cation binding inferred from electronic annotation with InterPro:IPR013781 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
carbohydrate metabolic process inferred from electronic annotation with InterPro:IPR001540, InterPro:IPR013781, InterPro:IPR015882 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hexo2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0041629 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31808
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19129 Dere\GG18269 Dgri\GH24516 Dmoj\GI15081 Dper\GL12954 Dpse\GA14705 Dsec\GM21777 Dsim\GD16914 Dvir\GJ18889 Dwil\GK10305 Dyak\GE15800
Curated drosophilid orthologs	Dana\Hexo2 (Intra et al., 2003) Dfun\Hexo2 (Intra et al., 2003) Dhyd\Hexo2 (Intra et al., 2003) Dleb\Hexo2 (Intra et al., 2003) Dpse\GA14705   Dvir\Hexo2 (Intra et al., 2003) Dwil\Hexo2 (Intra et al., 2003)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007839-PA Aedes aegypti (mosquito) AGAP012453-PA Anopheles gambiae (mosquito) XP_001950390.1 Acyrthosiphon pisum (pea aphid) BGIBMGA011646-PA Bombyx mori (silk worm) ENSBTAP00000017261 Bos taurus (bovine) ENSCAFP00000012168 Canis familiaris (dog) CPIJ001041 Culex pipens (mosquito) ENSCPOP00000005700 Cavia porcellus (guinea pig) ENSCPOP00000009629 Cavia porcellus (guinea pig) 183554 Capitella spl (polychaete worm) ENSECAP00000009930 Equus caballus (horse) ENSGACP00000006288 Gymnopilus aculeatus (mushroom) ENSGACP00000020965 Gymnopilus aculeatus (mushroom) ENSGALP00000002995 Gallus gallus (chicken) ENSP00000261416 Homo sapiens (human) ENSP00000268097 Homo sapiens (human) ISCW003575-PA Ixodes scapularis (deer tick) 18960 Monocosta brevicollis (choanoflagellate) ENSMODP00000002170 Monodelphis domestica (gray opossum) ENSMODP00000002282 Monodelphis domestica (gray opossum) ENSMMUP00000014005 Macaca mulatta (rhesus monkey) ENSMMUP00000026294 Macaca mulatta (rhesus monkey) ENSMUSP00000022169 Mus musculus (house mouse) ENSMUSP00000026262 Mus musculus (house mouse) XP_001603248.1 Nasonia vitripennis (wasp) ENSOANP00000024872 Ornithorynchus anatinus (platypus) PHUM000347-PA Pediculus humanus (human body louse) 128384 Physcomitrella patens (moss) ENSPPYP00000007503 Pongo pygmaeus (orangutan) ENSPTRP00000029093 Pan troglodytes (chimpanzee) ENSRNOP00000013747 Rattus norvegicus (norway rat) ENSRNOP00000044480 Rattus norvegicus (norway rat) Smp_053900 Schistosoma mansoni (trematode parasite) Smp_134300 Schistosoma mansoni (trematode parasite) NP_001092298.1 Tribolium castaneum (red flour beetle) 84692.m00150 Trichomonas vaginalis (parasitic flagellated protozoan) 97007.m00152 Trichomonas vaginalis (parasitic flagellated protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13911 ISCW003575 FBgn0233365 FBgn0212320 FBgn0206035 FBgn0188494 FBgn0176655 FBgn0074732 FBgn0150560 FBgn0137831 FBgn0131972 FBgn0110485 FBgn0096140 CPIJ001041 BGIBMGA014115 BGIBMGA011646 ACYPI39451 ACYPI25687 ACYPI009980 ACYPI007383 AGAP012453 AAEL007839 GLEAN_11540
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	18732 w1118 PBac{WH}Hexo2f04129
Harvard	- P{XP}Hexo2d06829 - PBac{WH}Hexo2f04129
VDRC	v5503 w1118; P{GD3287}v5503
Genomic Clones ( 2 )
	BACR14B08 BACR40O10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 74 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE07082
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06196 GH11303 GH15743 GH16671 GH24603 GM03963 HL05826 LP05820 LP16081 LP19535 RE08280 RE16657 RH04362 RH06672 RH10067 RH11394 RH11684 RH18568 RH21023 RH22287 RH26057 RH28536 RH34193 RH37313 RH43845 RH43857 RH44016 RH44283 RH45454 RH46285 RH47494 RH51046 RH51209 RH53275 RH63202 RH65950 RH67561 RH68780 RH71540 RH73677 SD02339 SD05059 SD06351 SD08215 SD08251 SD08303 SD10024 SD11230 SD11553 SD15132 SD15149 SD16327 SD18523 SD19017 SD23844 SD23866 SD26267 SD26632
Other clones	12064 66123 161014 214503.2 214503.16 522372 EK112938 EK194013 EK249202 EK265023 EN01916 EP06762 EP07962 IP03692 RH63089
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041629 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31808
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Hexo2 CG1787 (Palter, 2000.6.12)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080342 RefSeq (Proteins) • NP_525081 DDBJ / EMBL / GenBank • AAF46406 AAM48390 AI133986 AY118361 BI166855 CZ475381 CZ476399 CZ486657 CZ486658 Entrez Gene - A searchable database of RefSeq genes. • 31808 UniProtKB/TrEMBL • Q9W3C4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 20 (IPR001540) Glycoside hydrolase, family 20, catalytic core (IPR015883) Glycoside hydrolase, subgroup, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853) Acetylhexosaminidase, subunit a/b (IPR015882)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0041629 DRSC - Results from RNAi screens. • FBgn0041629 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041629 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1787-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041629 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31808 InParanoid A subset of ortholog calls from InParanoid. • AAEL007839-PA Aedes aegypti (mosquito) AGAP012453-PA Anopheles gambiae (mosquito) XP_001950390.1 Acyrthosiphon pisum (pea aphid) BGIBMGA011646-PA Bombyx mori (silk worm) ENSBTAP00000017261 Bos taurus (bovine) ENSCAFP00000012168 Canis familiaris (dog) CPIJ001041 Culex pipens (mosquito) ENSCPOP00000005700 Cavia porcellus (guinea pig) ENSCPOP00000009629 Cavia porcellus (guinea pig) 183554 Capitella spl (polychaete worm) ENSECAP00000009930 Equus caballus (horse) ENSGACP00000006288 Gymnopilus aculeatus (mushroom) ENSGACP00000020965 Gymnopilus aculeatus (mushroom) ENSGALP00000002995 Gallus gallus (chicken) ENSP00000261416 Homo sapiens (human) ENSP00000268097 Homo sapiens (human) ISCW003575-PA Ixodes scapularis (deer tick) 18960 Monocosta brevicollis (choanoflagellate) ENSMODP00000002170 Monodelphis domestica (gray opossum) ENSMODP00000002282 Monodelphis domestica (gray opossum) ENSMMUP00000014005 Macaca mulatta (rhesus monkey) ENSMMUP00000026294 Macaca mulatta (rhesus monkey) ENSMUSP00000022169 Mus musculus (house mouse) ENSMUSP00000026262 Mus musculus (house mouse) XP_001603248.1 Nasonia vitripennis (wasp) ENSOANP00000024872 Ornithorynchus anatinus (platypus) PHUM000347-PA Pediculus humanus (human body louse) 128384 Physcomitrella patens (moss) ENSPPYP00000007503 Pongo pygmaeus (orangutan) ENSPTRP00000029093 Pan troglodytes (chimpanzee) ENSRNOP00000013747 Rattus norvegicus (norway rat) ENSRNOP00000044480 Rattus norvegicus (norway rat) Smp_053900 Schistosoma mansoni (trematode parasite) Smp_134300 Schistosoma mansoni (trematode parasite) NP_001092298.1 Tribolium castaneum (red flour beetle) 84692.m00150 Trichomonas vaginalis (parasitic flagellated protozoan) 97007.m00152 Trichomonas vaginalis (parasitic flagellated protozoan) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31808 modMine - Data generated by the modENCODE project. • FBgn0041629 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13911 ISCW003575 FBgn0233365 FBgn0212320 FBgn0206035 FBgn0188494 FBgn0176655 FBgn0074732 FBgn0150560 FBgn0137831 FBgn0131972 FBgn0110485 FBgn0096140 CPIJ001041 BGIBMGA014115 BGIBMGA011646 ACYPI39451 ACYPI25687 ACYPI009980 ACYPI007383 AGAP012453 AAEL007839 GLEAN_11540
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG1787 (Cattaneo et al., 2006, Leonard et al., 2006, Cammarato et al., 2011) DmHex2 (Kim et al., 1999) HEX2 (Intra et al., 2003) HEX 2 (Cattaneo et al., 2001) Hexo2 (Cattaneo et al., 2006, Leonard et al., 2006, Macdonald and Long, 2007, Ayroles et al., 2009) HEXO2 (Leonard et al., 2006, Koo et al., 2008)
Name Synonym	Hexosaminidase 2 (Kim et al., 1999, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0030059
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Show all research papers ...