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Gene Dmel\7B2

General Information
Symbol	Dmel\7B2	Species	D. melanogaster
Name	7B2	Annotation symbol	CG1168
Feature type	protein_coding_gene	FlyBase ID	FBgn0041707
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	d7B2
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83A1-83A1	Sequence location	3R:1,202,476..1,203,701 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene 7B2 is referred to in FlyBase by the symbol Dmel\7B2 (CG1168, FBgn0041707). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: peptidase activator activity. There is experimental evidence that it is involved in the biological process: positive regulation of proteolysis. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Neuroendocrine 7B2 precursor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult midgut. Comments on Affy2 ProbeSet: ProbeSet 1636249_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of 7B2. Gene sequence location is 3R:1202476..1203701.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN31240 HFA11991
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83A1-83A1   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\7B2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Translation start as per SWP:Q9N9Z7
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) 7B2-RA FBtr0078789  NM_138986   1163   271 7B2-RB FBtr0301640  NM_001014608   1178   276
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein 7B2-PA   FBpp0078435   29.4   271   4.16     NP_620471   AAF52036 7B2-PB   FBpp0100150   30.0   276   4.21     NP_001014608   AAX52936
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Neuroendocrine 7B2 precursor (IPR007945)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698603   AE014297 AAF52036   AE014297 AAX52936   AI062015   AI063127   AI107302   AI114076   AI114199   AI293127   AI387073   AI388032   AI402702   AI403365   AI517488   AJ271974 CAB72934   AW941705   AY119453 AAM50107   BI171830   BI231112   BI485518   BI568685   BI588446   BI615565   BI617436   BI621114   BT014925   BT125782   CO177928   CO280084   CO285360   CO326203   EC069747   EC211197   EC233745   EC251807   EL870575   EL870576   EL872502   EL872503   EL872620   GH941434   GH944326   GH945112   GH945261   GH946259   GH946812   GH946886   GH947748   GH949014   GH950292   GH950735   GH951250   GH951514   GH951800   GH952179   GH952814   GH953331   GH953587   GH953915   GH954257   GH955356   GH955728   GH955992   GH956819   GH957682   GH957785   GH957805   GH957841   GH958804   GH958856   GH958916   GH959251   GH959257   GH959534   GH959758   GH960234   GH961329   GH961470   GH964271   GH964412   GH964599   GH964844   GH965150   GH966656   GH967311   GH967805   GH968416   GH969034   GH969264   GH969577   GH969719   GH969729   GH969851   GH969914   GH970820   GH971203   GH971398   GH971490   GH972114   GH972775   GH973223   GH973443   GH973754   GH974269   GH974785   GH976290   GH976488   GH976817   GH976902   GH977232   GH977372   GH977547   GH977895   GH977909   GH978666   GH978808   GH980478   GH980962   GH981956   GH982339   GH982394   GH982512   GH982988   GH983227   GH983259   GH983262   GH984769
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9N9Z7 Q9VNB0 Q59E04
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041707    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041707 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041707 expression level Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr    265 embryo 12-14hr    262 embryo 14-16hr    862 embryo 16-18hr    2054 embryo 18-20hr    3745 embryo 20-22hr    4297 embryo 22-24hr    4103 larva L1    6172 larva L2    2670 larva L3 12hr old    1076 larva L3 puffstage 1-2    1088 larva L3 puffstage 3-6    1325 larva L3 puffstage 7-9    1162 white prepupae new    986 white prepupae 12hr    1704 white prepupae 24hr    2213 pupae 2d postWPP    3435 pupae 3d postWPP    4731 pupae 4d postWPP    3615 adult male 01day    4111 adult male 05day    5069 adult male 30day    6392 adult female 01day    2682 adult female 05day    853 adult female 30day    973 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr  (265) embryo 12-14hr  (262) embryo 14-16hr  (862) embryo 16-18hr  (2054) embryo 18-20hr  (3745) embryo 20-22hr  (4297) embryo 22-24hr  (4103) larva L1  (6172) larva L2  (2670) larva L3 12hr old  (1076) larva L3 puffstage 1-2  (1088) larva L3 puffstage 3-6  (1325) larva L3 puffstage 7-9  (1162) white prepupae new  (986) white prepupae 12hr  (1704) white prepupae 24hr  (2213) pupae 2d postWPP  (3435) pupae 3d postWPP  (4731) pupae 4d postWPP  (3615) adult male 01day  (4111) adult male 05day  (5069) adult male 30day  (6392) adult female 01day  (2682) adult female 05day  (853) adult female 30day  (973) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr    265 embryo 12-14hr    262 embryo 14-16hr    862 embryo 16-18hr  (2054) embryo 18-20hr  (3745) embryo 20-22hr  (4297) embryo 22-24hr  (4103) larva L1  (6172) larva L2  (2670) larva L3 12hr old    1076 larva L3 puffstage 1-2    1088 larva L3 puffstage 3-6    1325 larva L3 puffstage 7-9    1162 white prepupae new    986 white prepupae 12hr  (1704) white prepupae 24hr  (2213) pupae 2d postWPP  (3435) pupae 3d postWPP  (4731) pupae 4d postWPP  (3615) adult male 01day  (4111) adult male 05day  (5069) adult male 30day  (6392) adult female 01day  (2682) adult female 05day    853 adult female 30day    973 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr    265 embryo 12-14hr    262 embryo 14-16hr    862 embryo 16-18hr    2054 embryo 18-20hr    3745 embryo 20-22hr    4297 embryo 22-24hr    4103 larva L1    6172 larva L2    2670 larva L3 12hr old    1076 larva L3 puffstage 1-2    1088 larva L3 puffstage 3-6    1325 larva L3 puffstage 7-9    1162 white prepupae new    986 white prepupae 12hr    1704 white prepupae 24hr    2213 pupae 2d postWPP    3435 pupae 3d postWPP    4731 pupae 4d postWPP    3615 adult male 01day    4111 adult male 05day    5069 adult male 30day    6392 adult female 01day    2682 adult female 05day    853 adult female 30day    973 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr    265 embryo 12-14hr    262 embryo 14-16hr    862 embryo 16-18hr    2054 embryo 18-20hr    3745 embryo 20-22hr    4297 embryo 22-24hr    4103 larva L1    6172 larva L2    2670 larva L3 12hr old    1076 larva L3 puffstage 1-2    1088 larva L3 puffstage 3-6    1325 larva L3 puffstage 7-9    1162 white prepupae new    986 white prepupae 12hr    1704 white prepupae 24hr    2213 pupae 2d postWPP    3435 pupae 3d postWPP    4731 pupae 4d postWPP    3615 adult male 01day    4111 adult male 05day    5069 adult male 30day    6392 adult female 01day    2682 adult female 05day    853 adult female 30day    973 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041707 expression level Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr    265 embryo 12-14hr    262 embryo 14-16hr    862 embryo 16-18hr    2054 embryo 18-20hr    3745 embryo 20-22hr    4297 embryo 22-24hr    4103 larva L1    6172 larva L2    2670 larva L3 12hr old    1076 larva L3 puffstage 1-2    1088 larva L3 puffstage 3-6    1325 larva L3 puffstage 7-9    1162 white prepupae new    986 white prepupae 12hr    1704 white prepupae 24hr    2213 pupae 2d postWPP    3435 pupae 3d postWPP    4731 pupae 4d postWPP    3615 adult male 01day    4111 adult male 05day    5069 adult male 30day    6392 adult female 01day    2682 adult female 05day    853 adult female 30day    973 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr  (265) embryo 12-14hr  (262) embryo 14-16hr  (862) embryo 16-18hr  (2054) embryo 18-20hr  (3745) embryo 20-22hr  (4297) embryo 22-24hr  (4103) larva L1  (6172) larva L2  (2670) larva L3 12hr old  (1076) larva L3 puffstage 1-2  (1088) larva L3 puffstage 3-6  (1325) larva L3 puffstage 7-9  (1162) white prepupae new  (986) white prepupae 12hr  (1704) white prepupae 24hr  (2213) pupae 2d postWPP  (3435) pupae 3d postWPP  (4731) pupae 4d postWPP  (3615) adult male 01day  (4111) adult male 05day  (5069) adult male 30day  (6392) adult female 01day  (2682) adult female 05day  (853) adult female 30day  (973) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr    265 embryo 12-14hr    262 embryo 14-16hr    862 embryo 16-18hr  2054 embryo 18-20hr  (3745) embryo 20-22hr  (4297) embryo 22-24hr  (4103) larva L1  (6172) larva L2  (2670) larva L3 12hr old    1076 larva L3 puffstage 1-2    1088 larva L3 puffstage 3-6    1325 larva L3 puffstage 7-9    1162 white prepupae new    986 white prepupae 12hr  1704 white prepupae 24hr  2213 pupae 2d postWPP  (3435) pupae 3d postWPP  (4731) pupae 4d postWPP  (3615) adult male 01day  (4111) adult male 05day  (5069) adult male 30day  (6392) adult female 01day  (2682) adult female 05day    853 adult female 30day    973 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr    265 embryo 12-14hr    262 embryo 14-16hr    862 embryo 16-18hr    2054 embryo 18-20hr    3745 embryo 20-22hr    4297 embryo 22-24hr    4103 larva L1    6172 larva L2    2670 larva L3 12hr old    1076 larva L3 puffstage 1-2    1088 larva L3 puffstage 3-6    1325 larva L3 puffstage 7-9    1162 white prepupae new    986 white prepupae 12hr    1704 white prepupae 24hr    2213 pupae 2d postWPP    3435 pupae 3d postWPP    4731 pupae 4d postWPP    3615 adult male 01day    4111 adult male 05day    5069 adult male 30day    6392 adult female 01day    2682 adult female 05day    853 adult female 30day    973 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    21 embryo 04-06hr    17 embryo 06-08hr    42 embryo 08-10hr    73 embryo 10-12hr    265 embryo 12-14hr    262 embryo 14-16hr    862 embryo 16-18hr    2054 embryo 18-20hr    3745 embryo 20-22hr    4297 embryo 22-24hr    4103 larva L1    6172 larva L2    2670 larva L3 12hr old    1076 larva L3 puffstage 1-2    1088 larva L3 puffstage 3-6    1325 larva L3 puffstage 7-9    1162 white prepupae new    986 white prepupae 12hr    1704 white prepupae 24hr    2213 pupae 2d postWPP    3435 pupae 3d postWPP    4731 pupae 4d postWPP    3615 adult male 01day    4111 adult male 05day    5069 adult male 30day    6392 adult female 01day    2682 adult female 05day    853 adult female 30day    973 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041707    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041707 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult midgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041707 expression level Tissue   Expression Level Larval Central Nervous System    984.025 Larval Midgut    99 Larval Hindgut    54.9 Larval Malpighian Tubules    3.3 Larval Fat Body    88.3 Larval Salivary Gland no informative data Larval Trachea    86.425 Larval Carcass no informative data Adult Head    1637.4 Adult Eye    2233.625 Adult Brain    2459.4 Adult Thoracic-Abdominal Ganglion    2391.4 Adult Crop    0.7 Adult Midgut    110.8 Adult Hindgut no informative data Adult Malpighian Tubules    3.6 Adult Fat Body    7.1 Adult Salivary Gland    2 Adult Heart    21.925 Adult VirginFemale Spermatheca    1.6 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    0.7 Adult Testis no informative data Adult Male Accessory Gland    1.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (984.025) Larval Midgut    99 Larval Hindgut    54.9 Larval Malpighian Tubules    3.3 Larval Fat Body    88.3 Larval Salivary Gland no informative data Larval Trachea    86.425 Larval Carcass no informative data Adult Head  (1637.4) Adult Eye  (2233.625) Adult Brain  (2459.4) Adult Thoracic-Abdominal Ganglion  (2391.4) Adult Crop    0.7 Adult Midgut    110.8 Adult Hindgut no informative data Adult Malpighian Tubules    3.6 Adult Fat Body    7.1 Adult Salivary Gland    2 Adult Heart    21.925 Adult VirginFemale Spermatheca    1.6 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    0.7 Adult Testis no informative data Adult Male Accessory Gland    1.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    984.025 Larval Midgut    99 Larval Hindgut    54.9 Larval Malpighian Tubules    3.3 Larval Fat Body    88.3 Larval Salivary Gland no informative data Larval Trachea    86.425 Larval Carcass no informative data Adult Head  (1637.4) Adult Eye  (2233.625) Adult Brain  (2459.4) Adult Thoracic-Abdominal Ganglion  (2391.4) Adult Crop    0.7 Adult Midgut    110.8 Adult Hindgut no informative data Adult Malpighian Tubules    3.6 Adult Fat Body    7.1 Adult Salivary Gland    2 Adult Heart    21.925 Adult VirginFemale Spermatheca    1.6 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    0.7 Adult Testis no informative data Adult Male Accessory Gland    1.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    984.025 Larval Midgut    99 Larval Hindgut    54.9 Larval Malpighian Tubules    3.3 Larval Fat Body    88.3 Larval Salivary Gland no informative data Larval Trachea    86.425 Larval Carcass no informative data Adult Head    1637.4 Adult Eye    2233.625 Adult Brain    2459.4 Adult Thoracic-Abdominal Ganglion    2391.4 Adult Crop    0.7 Adult Midgut    110.8 Adult Hindgut no informative data Adult Malpighian Tubules    3.6 Adult Fat Body    7.1 Adult Salivary Gland    2 Adult Heart    21.925 Adult VirginFemale Spermatheca    1.6 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    0.7 Adult Testis no informative data Adult Male Accessory Gland    1.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041707 expression level Tissue   Expression Level Larval Central Nervous System    984.025 Larval Midgut    99 Larval Hindgut    54.9 Larval Malpighian Tubules    3.3 Larval Fat Body    88.3 Larval Salivary Gland no informative data Larval Trachea    86.425 Larval Carcass no informative data Adult Head    1637.4 Adult Eye    2233.625 Adult Brain    2459.4 Adult Thoracic-Abdominal Ganglion    2391.4 Adult Crop    0.7 Adult Midgut    110.8 Adult Hindgut no informative data Adult Malpighian Tubules    3.6 Adult Fat Body    7.1 Adult Salivary Gland    2 Adult Heart    21.925 Adult VirginFemale Spermatheca    1.6 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    0.7 Adult Testis no informative data Adult Male Accessory Gland    1.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (984.025) Larval Midgut    99 Larval Hindgut    54.9 Larval Malpighian Tubules    3.3 Larval Fat Body    88.3 Larval Salivary Gland no informative data Larval Trachea    86.425 Larval Carcass no informative data Adult Head  (1637.4) Adult Eye  (2233.625) Adult Brain  (2459.4) Adult Thoracic-Abdominal Ganglion  (2391.4) Adult Crop    0.7 Adult Midgut    110.8 Adult Hindgut no informative data Adult Malpighian Tubules    3.6 Adult Fat Body    7.1 Adult Salivary Gland    2 Adult Heart    21.925 Adult VirginFemale Spermatheca    1.6 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    0.7 Adult Testis no informative data Adult Male Accessory Gland    1.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    984.025 Larval Midgut    99 Larval Hindgut    54.9 Larval Malpighian Tubules    3.3 Larval Fat Body    88.3 Larval Salivary Gland no informative data Larval Trachea    86.425 Larval Carcass no informative data Adult Head  1637.4 Adult Eye  (2233.625) Adult Brain  (2459.4) Adult Thoracic-Abdominal Ganglion  (2391.4) Adult Crop    0.7 Adult Midgut    110.8 Adult Hindgut no informative data Adult Malpighian Tubules    3.6 Adult Fat Body    7.1 Adult Salivary Gland    2 Adult Heart    21.925 Adult VirginFemale Spermatheca    1.6 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    0.7 Adult Testis no informative data Adult Male Accessory Gland    1.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    984.025 Larval Midgut    99 Larval Hindgut    54.9 Larval Malpighian Tubules    3.3 Larval Fat Body    88.3 Larval Salivary Gland no informative data Larval Trachea    86.425 Larval Carcass no informative data Adult Head    1637.4 Adult Eye    2233.625 Adult Brain    2459.4 Adult Thoracic-Abdominal Ganglion    2391.4 Adult Crop    0.7 Adult Midgut    110.8 Adult Hindgut no informative data Adult Malpighian Tubules    3.6 Adult Fat Body    7.1 Adult Salivary Gland    2 Adult Heart    21.925 Adult VirginFemale Spermatheca    1.6 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    0.7 Adult Testis no informative data Adult Male Accessory Gland    1.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1637.4   NA  Eye    2233.625   NA  Brain    2459.4   984.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2391.4   NA  Crop    0.7   99  Midgut    110.8   54.9  Hindgut    no informative data   3.3  Malpighian Tubules    3.6   88.3  Fat Body    7.1   no informative data  Salivary Gland    2   NA  Heart    21.925   86.425  Trachea    NA   NA  VirginFemale Spermatheca    1.6   NA  InseminatedFemale Spermatheca    1.9   NA  Ovary    0.7   NA  Testis    no informative data   NA  Male Accessory Gland    1.3   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041707 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1168-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for 7B2 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 7B2GD5583 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of 7B2 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of 7B2 Class Mutagen Stocks Known lesion 7B2GD5583 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes 7B2JF02917 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 7B2cHa in vitro construct 0 Yes 7B2KK111240 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5583} NA P{KK111240} NA P{TRiP.JF02917} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
peptidase activator activity inferred from direct assay (Hwang et al., 2000)
Biological Process
CV term Evidence References
positive regulation of proteolysis inferred from direct assay (Hwang et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neuropeptide signaling pathway inferred from electronic annotation with InterPro:IPR007945 (FlyBase Curators et al., 2004-) peptide hormone processing inferred from sequence or structural similarity with EMBL:U72709 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
stored secretory granule inferred from electronic annotation with InterPro:IPR007945 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions 7B2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65854 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041707 DroID - A comprehensive database of gene and protein interactions. • FBgn0041707 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40644
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17250 Dere\GG12793 Dgri\GH17856 Dmoj\GI22550 Dper\GL21643 Dpse\GA26358 Dsec\GM10806 Dsim\GD19785 Dvir\GJ11108 Dwil\GK11849 Dyak\GE25466
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002055-PA Aedes aegypti (mosquito) AGAP008082-PA Anopheles gambiae (mosquito) XP_392155.1 Apis mellifera (honey bee) XP_001944445.1 Acyrthosiphon pisum (pea aphid) BGIBMGA005220-PA Bombyx mori (silk worm) ENSBTAP00000043604 Bos taurus (bovine) CN07365 Caenorhabditis brenneri (small nematode) CBP01430 Caenorhabditis briggsae (nematode) CE18921 Caenorhabditis elegans (worm) ENSCAFP00000012083 Canis familiaris (dog) JA01799 Caenorhabditis japonica (nematode) CPIJ001887 Culex pipens (mosquito) ENSCPOP00000001847 Cavia porcellus (guinea pig) RP07035 Caenorhabditis remanei (nematode) 219677 Capitella spl (polychaete worm) 220347 Capitella spl (polychaete worm) 309672 Daphnia pulex (daphnia) ENSDARP00000045248 Danio rerio (zebra fish) ENSECAP00000020374 Equus caballus (horse) ENSGALP00000037122 Gallus gallus (chicken) 191041 Hypsipyla robusta (cedar shoot borer) ENSP00000300175 Homo sapiens (human) 133209 Lottia gigantea (owl limpet) ENSMODP00000001724 Monodelphis domestica (gray opossum) ENSMMUP00000015418 Macaca mulatta (rhesus monkey) ENSMMUP00000016114 Macaca mulatta (rhesus monkey) ENSMUSP00000024005 Mus musculus (house mouse) XP_001606058.1 Nasonia vitripennis (wasp) ENSORLP00000022377 Oryzias latipes (japanese killifish) PHUM003025-PA Pediculus humanus (human body louse) PP25797 Pristionchus pacificus (nematode) ENSPPYP00000007139 Pongo pygmaeus (orangutan) ENSPTRP00000011732 Pan troglodytes (chimpanzee) ENSRNOP00000010679 Rattus norvegicus (norway rat) XP_973692.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015184 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000046159 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15958 LH19023 ISCW008663 FBgn0242534 FBgn0213860 FBgn0198369 FBgn0191274 FBgn0165752 JGI_V11_309672 FBgn0247732 FBgn0159236 FBgn0145278 FBgn0125325 FBgn0105071 FBgn0094268 CPIJ001887 BGIBMGA005220 ACYPI009279 GB16545 AGAP008082 AAEL002055 PB22051 PHUM611520 GLEAN_08457
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	27989 y1 v1; P{TRiP.JF02917}attP2
VDRC	v30816 w1118; P{GD5583}v30816 v30817 w1118; P{GD5583}v30817
Genomic Clones ( 2 )
	BACR34M23 BACR42H10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 121 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT18965 GH01053 GH04952
Other clones	DPiM_GH01053
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02623 GH03891 GH10752 GH10928 GH16228 GH17503 GH18763 GH21975 GH22786 GH28456 HL05318 RE13693 RE19306 RE68864 RH29661 RH40350 RH45243 RH47771 RH52412
Other clones	39248 52681 214313.4 CK01.68B.E7 EK054720 EK152419 EK168830 EP03434 IP02641 IP04411 IP04511 RP004006726 RP004006886 RP004019357 RP004021138 RP004022408 RP004049389 RP004049886 RP004050795 RP004052836 RP004071188 RP004088404 RP004091775 RP004099716 RP004117174 RP004122193 RP004127625 RP004130511 RP004138700 RP004148477 RP004149198 RP004153518 RP004157045 RP004158677 RP004168515 RP004172261 RP004191983 RP004206473 RP004211852 RP004212199 RP004213061 RP004214713 RP004215188 RP004215387 RP004220699 RP004221785 RP004222218 RP004222675 RP004225917 RP004232034 RP004234892 RP004235947 RP004240893 RP004242211 RP004257429 RP004257520 RP004267132 RP004273699 RP004274067 RP004287416 RP004293090 RP004298179 RP004307758 RP004309654 RP004318440 RP004323374 RP004356513 RP004366892 RP004376244 RP004381409 RP004385224 RP004392216 RP004402055 RP004411967 RP004413399 RP004417010 RP004421378 RP004434581 RP004435655 RP004437092 RP004437495 RP004440302 RP004443796 RP004446802 RP004454830 RP004463115 RP004469311 RP004477565 RP004495120 RP004499309 RP004501711 RP004504463 RP004507377 RP004535200 RP004536108 RP004547355 RP004554123 RP004557093
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041707 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40644
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: 7B2 CG1168 (Taghert, 2000.5.2)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_138986 NM_001014608 RefSeq (Proteins) • NP_620471 NP_001014608 DDBJ / EMBL / GenBank • AAF52036 AAF52036.3 AAM50107 AAX52936 AI062015 AJ271974 AW941705 AY119453 CAB72934 Entrez Gene - A searchable database of RefSeq genes. • 40644 UniProtKB/TrEMBL • Q9N9Z7 Q9VNB0 Q59E04
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Neuroendocrine 7B2 precursor (IPR007945)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65854 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041707 DroID - A comprehensive database of gene and protein interactions. • FBgn0041707 DRSC - Results from RNAi screens. • FBgn0041707 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041707 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1168-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041707 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40644 InParanoid A subset of ortholog calls from InParanoid. • AAEL002055-PA Aedes aegypti (mosquito) AGAP008082-PA Anopheles gambiae (mosquito) XP_392155.1 Apis mellifera (honey bee) XP_001944445.1 Acyrthosiphon pisum (pea aphid) BGIBMGA005220-PA Bombyx mori (silk worm) ENSBTAP00000043604 Bos taurus (bovine) CN07365 Caenorhabditis brenneri (small nematode) CBP01430 Caenorhabditis briggsae (nematode) CE18921 Caenorhabditis elegans (worm) ENSCAFP00000012083 Canis familiaris (dog) JA01799 Caenorhabditis japonica (nematode) CPIJ001887 Culex pipens (mosquito) ENSCPOP00000001847 Cavia porcellus (guinea pig) RP07035 Caenorhabditis remanei (nematode) 219677 Capitella spl (polychaete worm) 220347 Capitella spl (polychaete worm) 309672 Daphnia pulex (daphnia) ENSDARP00000045248 Danio rerio (zebra fish) ENSECAP00000020374 Equus caballus (horse) ENSGALP00000037122 Gallus gallus (chicken) 191041 Hypsipyla robusta (cedar shoot borer) ENSP00000300175 Homo sapiens (human) 133209 Lottia gigantea (owl limpet) ENSMODP00000001724 Monodelphis domestica (gray opossum) ENSMMUP00000015418 Macaca mulatta (rhesus monkey) ENSMMUP00000016114 Macaca mulatta (rhesus monkey) ENSMUSP00000024005 Mus musculus (house mouse) XP_001606058.1 Nasonia vitripennis (wasp) ENSORLP00000022377 Oryzias latipes (japanese killifish) PHUM003025-PA Pediculus humanus (human body louse) PP25797 Pristionchus pacificus (nematode) ENSPPYP00000007139 Pongo pygmaeus (orangutan) ENSPTRP00000011732 Pan troglodytes (chimpanzee) ENSRNOP00000010679 Rattus norvegicus (norway rat) XP_973692.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015184 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000046159 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40644 modMine - Data generated by the modENCODE project. • FBgn0041707 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15958 LH19023 ISCW008663 FBgn0242534 FBgn0213860 FBgn0198369 FBgn0191274 FBgn0165752 JGI_V11_309672 FBgn0247732 FBgn0159236 FBgn0145278 FBgn0125325 FBgn0105071 FBgn0094268 CPIJ001887 BGIBMGA005220 ACYPI009279 GB16545 AGAP008082 AAEL002055 PB22051 PHUM611520 GLEAN_08457
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	7B2   CG1168 (Taghert, 2000.5.2, Waterhouse et al., 2007, Perkins et al., 2009, Haussmann et al., 2008, Keleman et al., 2009.8.5) d7B2 (Richer et al., 2004, Taghert, 2000.5.2, Hwang et al., 1999, Hwang et al., 2000) FBgn0040073   unnamed (Tellam et al., 2000)
Name Synonym	7B2
Secondary FlyBase IDs
	FBgn0037318
References ( 19 )
Research paper	Haussmann et al., 2008, Genome Biol. 9(4): R73 Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. [FBrf0209726] Waterhouse et al., 2007, Science 316(5832): 1738--1743 Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. [FBrf0200242] Richer et al., 2004, Proc. Natl. Acad. Sci. USA 101(29): 10560--10565 The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. [FBrf0179410] Hwang et al., 2000, J. Biol. Chem. 275(23): 17886--17893 Interaction of Drosophila melanogaster prohormone Convertase 2 and 7B2. Insect cell-specific processing and secretion. [FBrf0128499] Tellam et al., 2000, Europ. J. Biochem. 267(19): 6025--6043 Insect chitin synthase cDNA sequence, gene organization and expression. [FBrf0130241]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Taghert, 2000.5.2, d7B2 EST ID number. d7B2 EST ID number. [FBrf0129037]
Abstract	Hwang et al., 1999, Molec. Biol. Cell 10(Suppl.): 108a Prohormone convertase 2 and 7B2 from Drosophila melanogaster: Insect cell-specific expression of activity. [FBrf0123056]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Kodira, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126678]