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Gene Dmel\SCAR

General Information
Symbol	Dmel\SCAR	Species	D. melanogaster
Name	SCAR	Annotation symbol	CG4636
Feature type	protein_coding_gene	FlyBase ID	FBgn0041781
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	Wave, l(2)k03107, DWave
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	32C1-32C1	Sequence location	2L:10,976,774..10,982,397 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene SCAR is referred to in FlyBase by the symbol Dmel\SCAR (CG4636, FBgn0041781). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence for 16 unique biological process terms, many of which group under: cellular component organization or biogenesis; actin filament-based process; biological regulation; organelle organization; neuron differentiation; system development; localization; neuron projection development; sensory organ development; muscle cell differentiation. 18 alleles are reported. The phenotypes of these alleles are annotated with: intersegmental nerve; embryonic myoblast; actin filament; axon; embryonic/larval somatic muscle. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Actin-binding WH2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval hindgut, larval Malpighian tubules, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638871_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of SCAR. Gene sequence location is 2L:10976774..10982397.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098 Bakal et al., 2007, Science 316(5832): 1753--1756
FB2012_01	Unknown in situ References Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092 Gautier et al., 2011, J. Cell Sci. 124(20): 3414--3427 D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 Picone et al., 2010, PLoS Biol. 8(11): e1000542 Controlled Vocabulary Terms regulation of cell diameter cell morphogenesis Golgi organization Sequence features HFA03426 BKN22532
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32C1-32C1   Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32C-32C     (Dickson, 2000.3.23) 32C-32C     (Schejter, 2000.3.6) 32C1-32C2   (determined by in situ hybridisation)   (Spradling et al., 1999) 32C1-32C2   32C3--5   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\SCAR for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) SCAR-RA FBtr0080148  NM_135633   2832   613 SCAR-RB FBtr0305255     2911   641 SCAR-RC FBtr0305256     2908   640
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein SCAR-PA   FBpp0079737   67.1   613   7.29     NP_609477   AAF53042 SCAR-PB   FBpp0293779   70.2   641   6.92       SCAR-PC   FBpp0293780   70.0   640   7.32
Additional Polypeptide Data & Comments
Reported size (kDa)	613 (aa) (Zallen et al., 2002)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding WH2 (IPR003124)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567420   AA695688   AE014134 AAF53042   AF247763 AAF74194   AI297149   AI531571   AI531743   AI532124   AI533543   AI534964   AI544304   AI945364   AQ025718   AQ026072   AW941193   AW944276   AY060859 AAL28407   AY061579 AAL29127   BI163096   BI163272   BI164595   BI173186   BI173842   BI173931   BI235618   BI237193   BI237194   BI362797   BI364348   BI365933   BI580624   BI635887   BI636489   BI637264   BP553308   BQ103189   BT081354   BT126168   CO180896   CO189823   CO269752   CO271833   CO277852   CO279171   CO300562   CO310757   CO318510   CO323838   CO333505   EC058184   EC060139   EC069427   EC072514   EC084412   EC202131   EC220487   EC227201   EC229989   EC234668   EC244397   EC246655   EC251245   EV586019   EV587504   EV590387   EV590812   GH748204   GH748822   GH751551   GH752403   GH753864   GH754471   GH758118   GH771981   GH774288   GH777195   GH777926   GH778494   GH778794   GH781923   GH783697   GH785108   GH785586   GH789677   GH793288   GH793862   GH796324   GH798595   GH799603   GH799899   GH801940   GH803063   GH803480   GH803732   GH804198   GH805076   GH805277   GH807871   GH810354   GH812077   GH817463   GH818633   GH821676   GH823875   GH827775   GH830456   GH830684   GH832062   GH833239   GH834125   GH834419   GH835494   GH836207   GH838067   GH838367   GH838608   GH840388   GH840936   GH841278   GH841340   GH841358   GH842443   GH843186   GH844042   GH844320   GH845142   GH846296   GH846441   GH848233   GH848261   GH848316   GH848884   GH850165   GH851856   GH852443   GH854580   GH854590   GH864376   GH865664   GH866941   GH867669   GH867739   GH877086   GH878052   GH882096   GH886386   GH886588   GH886909   GH887337   GH887670   GH888205   GH889243   GH892064   GH893621   GH896502   GH897227   GH903832   GH908352   GH912577   GH913018   GH914248   GH915168   GH915282   GH917120   GH917236   GH919911   GH920415   GH925620   GH926244   GH927145   GH927949   GH928331   GH928538   GH928764   GH930470   GH933945   GH934217   GH935814   GH936076   GH938760
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VKM2 Q95SC7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Schenck et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   neuron of presumptive embryonic/larval central nervous system   • axon (Zallen et al., 2002) blastoderm stage     • actin filament (Zallen et al., 2002) embryonic stage 14 -- 16   commissure   (Schenck et al., 2004) embryonic stage 14 -- 17   longitudinal connective   (Schenck et al., 2004) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 17     (Schenck et al., 2004)   cell   (Schenck et al., 2004) Comment:expression assayed in cultured S2 cells
Additional Descriptive Data
	SCAR protein is present in early blastoderm embryos where it colocalizes with filamentous actin structures. It is also expressed in the axons of the central nervous system in later embryos. (Zallen et al., 2002) SCAR protein presents as a doublet on Western blots; one isoform may represent posttranslational modification. (Schenck et al., 2004)
Marker for
	longitudinal connective
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041781    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041781 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041781 expression level Developmental Stage   Expression Level embryo 00-02hr    4671 embryo 02-04hr    904 embryo 04-06hr    1794 embryo 06-08hr    2985 embryo 08-10hr    3075 embryo 10-12hr    4050 embryo 12-14hr    2543 embryo 14-16hr    2998 embryo 16-18hr    2647 embryo 18-20hr    2232 embryo 20-22hr    1643 embryo 22-24hr    1581 larva L1    2003 larva L2    1368 larva L3 12hr old    1145 larva L3 puffstage 1-2    1177 larva L3 puffstage 3-6    2011 larva L3 puffstage 7-9    2367 white prepupae new    2552 white prepupae 12hr    2429 white prepupae 24hr    2663 pupae 2d postWPP    2697 pupae 3d postWPP    1976 pupae 4d postWPP    1691 adult male 01day    1627 adult male 05day    1859 adult male 30day    2114 adult female 01day    2955 adult female 05day    3269 adult female 30day    3333 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4671) embryo 02-04hr  (904) embryo 04-06hr  (1794) embryo 06-08hr  (2985) embryo 08-10hr  (3075) embryo 10-12hr  (4050) embryo 12-14hr  (2543) embryo 14-16hr  (2998) embryo 16-18hr  (2647) embryo 18-20hr  (2232) embryo 20-22hr  (1643) embryo 22-24hr  (1581) larva L1  (2003) larva L2  (1368) larva L3 12hr old  (1145) larva L3 puffstage 1-2  (1177) larva L3 puffstage 3-6  (2011) larva L3 puffstage 7-9  (2367) white prepupae new  (2552) white prepupae 12hr  (2429) white prepupae 24hr  (2663) pupae 2d postWPP  (2697) pupae 3d postWPP  (1976) pupae 4d postWPP  (1691) adult male 01day  (1627) adult male 05day  (1859) adult male 30day  (2114) adult female 01day  (2955) adult female 05day  (3269) adult female 30day  (3333) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4671) embryo 02-04hr    904 embryo 04-06hr  (1794) embryo 06-08hr  (2985) embryo 08-10hr  (3075) embryo 10-12hr  (4050) embryo 12-14hr  (2543) embryo 14-16hr  (2998) embryo 16-18hr  (2647) embryo 18-20hr  (2232) embryo 20-22hr  (1643) embryo 22-24hr  (1581) larva L1  (2003) larva L2    1368 larva L3 12hr old    1145 larva L3 puffstage 1-2    1177 larva L3 puffstage 3-6  (2011) larva L3 puffstage 7-9  (2367) white prepupae new  (2552) white prepupae 12hr  (2429) white prepupae 24hr  (2663) pupae 2d postWPP  (2697) pupae 3d postWPP  (1976) pupae 4d postWPP  (1691) adult male 01day  (1627) adult male 05day  (1859) adult male 30day  (2114) adult female 01day  (2955) adult female 05day  (3269) adult female 30day  (3333) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4671 embryo 02-04hr    904 embryo 04-06hr    1794 embryo 06-08hr    2985 embryo 08-10hr    3075 embryo 10-12hr    4050 embryo 12-14hr    2543 embryo 14-16hr    2998 embryo 16-18hr    2647 embryo 18-20hr    2232 embryo 20-22hr    1643 embryo 22-24hr    1581 larva L1    2003 larva L2    1368 larva L3 12hr old    1145 larva L3 puffstage 1-2    1177 larva L3 puffstage 3-6    2011 larva L3 puffstage 7-9    2367 white prepupae new    2552 white prepupae 12hr    2429 white prepupae 24hr    2663 pupae 2d postWPP    2697 pupae 3d postWPP    1976 pupae 4d postWPP    1691 adult male 01day    1627 adult male 05day    1859 adult male 30day    2114 adult female 01day    2955 adult female 05day    3269 adult female 30day    3333 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4671 embryo 02-04hr    904 embryo 04-06hr    1794 embryo 06-08hr    2985 embryo 08-10hr    3075 embryo 10-12hr    4050 embryo 12-14hr    2543 embryo 14-16hr    2998 embryo 16-18hr    2647 embryo 18-20hr    2232 embryo 20-22hr    1643 embryo 22-24hr    1581 larva L1    2003 larva L2    1368 larva L3 12hr old    1145 larva L3 puffstage 1-2    1177 larva L3 puffstage 3-6    2011 larva L3 puffstage 7-9    2367 white prepupae new    2552 white prepupae 12hr    2429 white prepupae 24hr    2663 pupae 2d postWPP    2697 pupae 3d postWPP    1976 pupae 4d postWPP    1691 adult male 01day    1627 adult male 05day    1859 adult male 30day    2114 adult female 01day    2955 adult female 05day    3269 adult female 30day    3333 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041781 expression level Developmental Stage   Expression Level embryo 00-02hr    4671 embryo 02-04hr    904 embryo 04-06hr    1794 embryo 06-08hr    2985 embryo 08-10hr    3075 embryo 10-12hr    4050 embryo 12-14hr    2543 embryo 14-16hr    2998 embryo 16-18hr    2647 embryo 18-20hr    2232 embryo 20-22hr    1643 embryo 22-24hr    1581 larva L1    2003 larva L2    1368 larva L3 12hr old    1145 larva L3 puffstage 1-2    1177 larva L3 puffstage 3-6    2011 larva L3 puffstage 7-9    2367 white prepupae new    2552 white prepupae 12hr    2429 white prepupae 24hr    2663 pupae 2d postWPP    2697 pupae 3d postWPP    1976 pupae 4d postWPP    1691 adult male 01day    1627 adult male 05day    1859 adult male 30day    2114 adult female 01day    2955 adult female 05day    3269 adult female 30day    3333 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4671) embryo 02-04hr  (904) embryo 04-06hr  (1794) embryo 06-08hr  (2985) embryo 08-10hr  (3075) embryo 10-12hr  (4050) embryo 12-14hr  (2543) embryo 14-16hr  (2998) embryo 16-18hr  (2647) embryo 18-20hr  (2232) embryo 20-22hr  (1643) embryo 22-24hr  (1581) larva L1  (2003) larva L2  (1368) larva L3 12hr old  (1145) larva L3 puffstage 1-2  (1177) larva L3 puffstage 3-6  (2011) larva L3 puffstage 7-9  (2367) white prepupae new  (2552) white prepupae 12hr  (2429) white prepupae 24hr  (2663) pupae 2d postWPP  (2697) pupae 3d postWPP  (1976) pupae 4d postWPP  (1691) adult male 01day  (1627) adult male 05day  (1859) adult male 30day  (2114) adult female 01day  (2955) adult female 05day  (3269) adult female 30day  (3333) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4671) embryo 02-04hr    904 embryo 04-06hr  1794 embryo 06-08hr  (2985) embryo 08-10hr  (3075) embryo 10-12hr  (4050) embryo 12-14hr  (2543) embryo 14-16hr  (2998) embryo 16-18hr  (2647) embryo 18-20hr  2232 embryo 20-22hr  1643 embryo 22-24hr  1581 larva L1  2003 larva L2    1368 larva L3 12hr old    1145 larva L3 puffstage 1-2    1177 larva L3 puffstage 3-6  2011 larva L3 puffstage 7-9  2367 white prepupae new  (2552) white prepupae 12hr  2429 white prepupae 24hr  (2663) pupae 2d postWPP  (2697) pupae 3d postWPP  1976 pupae 4d postWPP  1691 adult male 01day  1627 adult male 05day  1859 adult male 30day  2114 adult female 01day  (2955) adult female 05day  (3269) adult female 30day  (3333) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4671 embryo 02-04hr    904 embryo 04-06hr    1794 embryo 06-08hr    2985 embryo 08-10hr    3075 embryo 10-12hr    4050 embryo 12-14hr    2543 embryo 14-16hr    2998 embryo 16-18hr    2647 embryo 18-20hr    2232 embryo 20-22hr    1643 embryo 22-24hr    1581 larva L1    2003 larva L2    1368 larva L3 12hr old    1145 larva L3 puffstage 1-2    1177 larva L3 puffstage 3-6    2011 larva L3 puffstage 7-9    2367 white prepupae new    2552 white prepupae 12hr    2429 white prepupae 24hr    2663 pupae 2d postWPP    2697 pupae 3d postWPP    1976 pupae 4d postWPP    1691 adult male 01day    1627 adult male 05day    1859 adult male 30day    2114 adult female 01day    2955 adult female 05day    3269 adult female 30day    3333 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4671 embryo 02-04hr    904 embryo 04-06hr    1794 embryo 06-08hr    2985 embryo 08-10hr    3075 embryo 10-12hr    4050 embryo 12-14hr    2543 embryo 14-16hr    2998 embryo 16-18hr    2647 embryo 18-20hr    2232 embryo 20-22hr    1643 embryo 22-24hr    1581 larva L1    2003 larva L2    1368 larva L3 12hr old    1145 larva L3 puffstage 1-2    1177 larva L3 puffstage 3-6    2011 larva L3 puffstage 7-9    2367 white prepupae new    2552 white prepupae 12hr    2429 white prepupae 24hr    2663 pupae 2d postWPP    2697 pupae 3d postWPP    1976 pupae 4d postWPP    1691 adult male 01day    1627 adult male 05day    1859 adult male 30day    2114 adult female 01day    2955 adult female 05day    3269 adult female 30day    3333 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041781    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041781 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval hindgut, larval Malpighian tubules, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041781 expression level Tissue   Expression Level Larval Central Nervous System    606.05 Larval Midgut    470.3 Larval Hindgut    550.3 Larval Malpighian Tubules    616.9 Larval Fat Body    462.4 Larval Salivary Gland    449.3 Larval Trachea    353.175 Larval Carcass    330.15 Adult Head    357.2 Adult Eye    342.175 Adult Brain    641.3 Adult Thoracic-Abdominal Ganglion    563.2 Adult Crop    481.5 Adult Midgut    294.1 Adult Hindgut    332 Adult Malpighian Tubules    283.4 Adult Fat Body    292.6 Adult Salivary Gland    418.7 Adult Heart    312.1 Adult VirginFemale Spermatheca    316 Adult InseminatedFemale Spermatheca    382.7 Adult Ovary    597.1 Adult Testis    138.7 Adult Male Accessory Gland    386.8 Adult Carcass    209.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (606.05) Larval Midgut    470.3 Larval Hindgut  (550.3) Larval Malpighian Tubules  (616.9) Larval Fat Body    462.4 Larval Salivary Gland    449.3 Larval Trachea    353.175 Larval Carcass    330.15 Adult Head    357.2 Adult Eye    342.175 Adult Brain  (641.3) Adult Thoracic-Abdominal Ganglion  (563.2) Adult Crop    481.5 Adult Midgut    294.1 Adult Hindgut    332 Adult Malpighian Tubules    283.4 Adult Fat Body    292.6 Adult Salivary Gland    418.7 Adult Heart    312.1 Adult VirginFemale Spermatheca    316 Adult InseminatedFemale Spermatheca    382.7 Adult Ovary  (597.1) Adult Testis    138.7 Adult Male Accessory Gland    386.8 Adult Carcass    209.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    606.05 Larval Midgut    470.3 Larval Hindgut    550.3 Larval Malpighian Tubules    616.9 Larval Fat Body    462.4 Larval Salivary Gland    449.3 Larval Trachea    353.175 Larval Carcass    330.15 Adult Head    357.2 Adult Eye    342.175 Adult Brain    641.3 Adult Thoracic-Abdominal Ganglion    563.2 Adult Crop    481.5 Adult Midgut    294.1 Adult Hindgut    332 Adult Malpighian Tubules    283.4 Adult Fat Body    292.6 Adult Salivary Gland    418.7 Adult Heart    312.1 Adult VirginFemale Spermatheca    316 Adult InseminatedFemale Spermatheca    382.7 Adult Ovary    597.1 Adult Testis    138.7 Adult Male Accessory Gland    386.8 Adult Carcass    209.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    606.05 Larval Midgut    470.3 Larval Hindgut    550.3 Larval Malpighian Tubules    616.9 Larval Fat Body    462.4 Larval Salivary Gland    449.3 Larval Trachea    353.175 Larval Carcass    330.15 Adult Head    357.2 Adult Eye    342.175 Adult Brain    641.3 Adult Thoracic-Abdominal Ganglion    563.2 Adult Crop    481.5 Adult Midgut    294.1 Adult Hindgut    332 Adult Malpighian Tubules    283.4 Adult Fat Body    292.6 Adult Salivary Gland    418.7 Adult Heart    312.1 Adult VirginFemale Spermatheca    316 Adult InseminatedFemale Spermatheca    382.7 Adult Ovary    597.1 Adult Testis    138.7 Adult Male Accessory Gland    386.8 Adult Carcass    209.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041781 expression level Tissue   Expression Level Larval Central Nervous System    606.05 Larval Midgut    470.3 Larval Hindgut    550.3 Larval Malpighian Tubules    616.9 Larval Fat Body    462.4 Larval Salivary Gland    449.3 Larval Trachea    353.175 Larval Carcass    330.15 Adult Head    357.2 Adult Eye    342.175 Adult Brain    641.3 Adult Thoracic-Abdominal Ganglion    563.2 Adult Crop    481.5 Adult Midgut    294.1 Adult Hindgut    332 Adult Malpighian Tubules    283.4 Adult Fat Body    292.6 Adult Salivary Gland    418.7 Adult Heart    312.1 Adult VirginFemale Spermatheca    316 Adult InseminatedFemale Spermatheca    382.7 Adult Ovary    597.1 Adult Testis    138.7 Adult Male Accessory Gland    386.8 Adult Carcass    209.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  606.05 Larval Midgut    470.3 Larval Hindgut  550.3 Larval Malpighian Tubules  616.9 Larval Fat Body    462.4 Larval Salivary Gland    449.3 Larval Trachea    353.175 Larval Carcass    330.15 Adult Head    357.2 Adult Eye    342.175 Adult Brain  641.3 Adult Thoracic-Abdominal Ganglion  563.2 Adult Crop    481.5 Adult Midgut    294.1 Adult Hindgut    332 Adult Malpighian Tubules    283.4 Adult Fat Body    292.6 Adult Salivary Gland    418.7 Adult Heart    312.1 Adult VirginFemale Spermatheca    316 Adult InseminatedFemale Spermatheca    382.7 Adult Ovary  597.1 Adult Testis    138.7 Adult Male Accessory Gland    386.8 Adult Carcass    209.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    606.05 Larval Midgut    470.3 Larval Hindgut    550.3 Larval Malpighian Tubules    616.9 Larval Fat Body    462.4 Larval Salivary Gland    449.3 Larval Trachea    353.175 Larval Carcass    330.15 Adult Head    357.2 Adult Eye    342.175 Adult Brain    641.3 Adult Thoracic-Abdominal Ganglion    563.2 Adult Crop    481.5 Adult Midgut    294.1 Adult Hindgut    332 Adult Malpighian Tubules    283.4 Adult Fat Body    292.6 Adult Salivary Gland    418.7 Adult Heart    312.1 Adult VirginFemale Spermatheca    316 Adult InseminatedFemale Spermatheca    382.7 Adult Ovary    597.1 Adult Testis    138.7 Adult Male Accessory Gland    386.8 Adult Carcass    209.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    606.05 Larval Midgut    470.3 Larval Hindgut    550.3 Larval Malpighian Tubules    616.9 Larval Fat Body    462.4 Larval Salivary Gland    449.3 Larval Trachea    353.175 Larval Carcass    330.15 Adult Head    357.2 Adult Eye    342.175 Adult Brain    641.3 Adult Thoracic-Abdominal Ganglion    563.2 Adult Crop    481.5 Adult Midgut    294.1 Adult Hindgut    332 Adult Malpighian Tubules    283.4 Adult Fat Body    292.6 Adult Salivary Gland    418.7 Adult Heart    312.1 Adult VirginFemale Spermatheca    316 Adult InseminatedFemale Spermatheca    382.7 Adult Ovary    597.1 Adult Testis    138.7 Adult Male Accessory Gland    386.8 Adult Carcass    209.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    357.2   NA  Eye    342.175   NA  Brain    641.3   606.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    563.2   NA  Crop    481.5   470.3  Midgut    294.1   550.3  Hindgut    332   616.9  Malpighian Tubules    283.4   462.4  Fat Body    292.6   449.3  Salivary Gland    418.7   NA  Heart    312.1   353.175  Trachea    NA   NA  VirginFemale Spermatheca    316   NA  InseminatedFemale Spermatheca    382.7   NA  Ovary    597.1   NA  Testis    138.7   NA  Male Accessory Gland    386.8   330.15  Carcass    209.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041781 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4636-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive SCARk03107 SCARK13811 SCARk13811 SCARΔ37 viable, with Scer\GAL4elav-C155 SCARScer\UAS.P\T.cZa viable, with Scer\GAL4pnr-MD237 SCARGD11380 Sterility Allele fertile | germline clone SCARK13811 sterile | germline clone SCARΔ37 Other Phenotypes Allele cell shape defective SCARdsRNA.cKa neuroanatomy defective SCARk13811 neuroanatomy defective | dominant SCARΔ37 Phenotype manifest in Allele actin filament SCARdsRNA.cBa actin filament | embryonic stage 4 | germline clone | non-rescuable maternal effect SCARK13811 axon SCARΔ37 embryonic/larval somatic muscle SCARΔ37 embryonic myoblast SCARΔ37 embryonic myoblast | germline clone SCARk13811 eye | somatic clone SCARΔ37 interommatidial bristle | somatic clone SCARΔ37 intersegmental nerve SCARΔ37 longitudinal connective | rescuable maternal effect SCARK13811 myoblast | embryonic stage SCARΔ37 SCARk13811 neuromuscular junction & synapse SCARΔ37 nucleus | embryonic stage 4 | germline clone | non-rescuable maternal effect SCARK13811 nurse cell | germline clone SCARΔ37 nurse cell ring canal | germline clone SCARΔ37 ommatidium | somatic clone SCARΔ37 ventral nerve cord | rescuable maternal effect SCARK13811 ventral nerve cord commissure | rescuable maternal effect SCARK13811
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of SCAR Class Mutagen Stocks Known lesion SCARk03107 P-element activity 2 -- SCARG12874 P-element activity 1 -- SCARk13811 hypomorphic allele - genetic evidence P-element activity 1 -- SCARNP4622 1 -- SCARΔ37 loss of function allele Delta2-3 1 -- SCARK13811 hypomorphic allele - genetic evidence P-element activity 0 Yes SCARNP4242 0 -- SCARunspecified 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of SCAR Class Mutagen Stocks Known lesion SCARGD11380 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SCARHMS01536 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SCARJF01599 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SCARdsRNA.cBa in vitro construct - RNAi 0 Yes SCARdsRNA.cKa in vitro construct - RNAi 0 Yes SCARPVCA.Act5C.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SCARScer\UAS.cFa in vitro construct - regulatory fusion 0 Yes SCARScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes SCARScer\UAS.P\T.cZa in vitro construct - regulatory fusion 0 Yes SCARScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC32 (Deal and Cook, 2003.7.11) Df(2L)Δ37 (Zallen et al., 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11380} NA P{TRiP.HMS01536} NA P{TRiP.JF01599} NA P{UASp-SCAR.Z} NA P{UAS-SCAR.EGFP} NA P{UAS-SCAR.F} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH1938SH1938 No P{lacW}SCARk03107 No P{lacW}SCARk13811 No P{lacW}SCARK13811 No insertion of enhancer trap binary system P{GawB}SCARNP4242 No P{GawB}SCARNP4622 No insertion of mobile activating element P{EP}SCARG12874 NA
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Richardson et al., 2007) actin filament organization inferred from mutant phenotype (Kiger et al., 2003) actin filament reorganization involved in cell cycle inferred from mutant phenotype (Zallen et al., 2002) Arp2/3 complex-mediated actin nucleation inferred from direct assay (Liu et al., 2009) axonal fasciculation inferred from mutant phenotype (Zallen et al., 2002) axonogenesis inferred from mutant phenotype (Zallen et al., 2002) cell morphogenesis inferred from mutant phenotype (D'Ambrosio and Vale, 2010) cell projection assembly inferred from mutant phenotype (Kunda et al., 2003) compound eye morphogenesis inferred from mutant phenotype (Zallen et al., 2002) cortical actin cytoskeleton organization inferred from mutant phenotype (Kunda et al., 2003) female germline ring canal stabilization inferred from mutant phenotype (Zallen et al., 2002) Golgi organization inferred from mutant phenotype (Kondylis et al., 2011) myoblast fusion inferred from genetic interaction with Vrp1 (Berger et al., 2008) inferred from genetic interaction with WASp (Berger et al., 2008) inferred from mutant phenotype (Berger et al., 2008, Richardson et al., 2007) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) regulation of cell diameter inferred from mutant phenotype (Kondylis et al., 2011) regulation of cell shape inferred from mutant phenotype (Kunda et al., 2003, Kiger et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
actin filament-based process traceable author statement (Vartiainen and Machesky, 2004) cytoskeleton organization non-traceable author statement (Dickson, 2000.3.23)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions SCAR allele Gene References SCARdsRNA.cBa Hem (Bogdan and Klambt, 2003) SCARK13811 WASp (Zallen et al., 2002) SCARScer\UAS.P\T.cZa LIMK1 (Ng and Luo, 2004) SCARunspecified Hem (Bogdan and Klambt, 2003) SCARΔ37 Fmr1 (Schenck et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60587 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041781 DroID - A comprehensive database of gene and protein interactions. • FBgn0041781 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34519
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15838 Dere\GG23688 Dgri\GH10763 Dmoj\GI20586 Dper\GL19132 Dpse\GA18320 Dsec\GM18775 Dsim\GD23745 Dvir\GJ13927 Dwil\GK14890 Dyak\GE18500
Curated drosophilid orthologs	Dpse\GA18320
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012519-PA Aedes aegypti (mosquito) AGAP008518-PA Anopheles gambiae (mosquito) XP_394398.1 Apis mellifera (honey bee) XP_001943697.1 Acyrthosiphon pisum (pea aphid) 34265 Batrachochytrium dendrobatidis (chytrid fungus) 133270 Branchiostoma floridae (lancelet) XP_001902396.1 Brugia malayi (roundworm nematode) BGIBMGA007478-PA Bombyx mori (silk worm) ENSBTAP00000019468 Bos taurus (bovine) CN19054 Caenorhabditis brenneri (small nematode) CBP34983 Caenorhabditis briggsae (nematode) CE36188 Caenorhabditis elegans (worm) ENSCAFP00000017843 Canis familiaris (dog) ENSCINP00000025762 Ciona intestinalis (sea squirt) JA18427 Caenorhabditis japonica (nematode) CPIJ000362 Culex pipens (mosquito) ENSCPOP00000009121 Cavia porcellus (guinea pig) RP25470 Caenorhabditis remanei (nematode) ENSCSAVP00000010971 Ciona savignyi (sedentary tunicate) 219958 Capitella spl (polychaete worm) DDB0191148 Dictyostelium discoideum (amoeba) 308566 Daphnia pulex (daphnia) ENSDARP00000093195 Danio rerio (zebra fish) ENSECAP00000000057 Equus caballus (horse) ENSGACP00000007637 Gymnopilus aculeatus (mushroom) ENSGALP00000027574 Gallus gallus (chicken) 181744 Hypsipyla robusta (cedar shoot borer) ENSP00000370877 Homo sapiens (human) ISCW007639-PA Ixodes scapularis (deer tick) 38487 Monocosta brevicollis (choanoflagellate) ENSMODP00000010952 Monodelphis domestica (gray opossum) ENSMMUP00000006698 Macaca mulatta (rhesus monkey) ENSMUSP00000016143 Mus musculus (house mouse) XP_001607386.1 Nasonia vitripennis (wasp) ENSOANP00000014407 Ornithorynchus anatinus (platypus) ENSORLP00000017542 Oryzias latipes (japanese killifish) LOC_Os01g11040.1 Oryza sativa (asian rice) PHUM004926-PA Pediculus humanus (human body louse) 95614 Physcomitrella patens (moss) ENSPPYP00000005957 Pongo pygmaeus (orangutan) 555676 Populus trichocarpa (black cottonwood) ENSPTRP00000040016 Pan troglodytes (chimpanzee) ENSRNOP00000013117 Rattus norvegicus (norway rat) Smp_078050 Schistosoma mansoni (trematode parasite) XP_001191393.1 Strongylocentrotus purpuratus (purple sea urchin) XP_973241.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021795 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031626 Takifugu rubripes (pufferfish Takifugu) 83641.m00142 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000044664 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11656 NV11801 LH18943 ISCW007639 FBgn0235914 FBgn0216895 FBgn0201145 FBgn0195118 FBgn0173680 JGI_V11_308566 FBgn0078325 FBgn0156731 FBgn0143321 FBgn0118244 FBgn0115829 FBgn0092862 CPIJ000362 BGIBMGA007478 ACYPI007366 GB14671 AGAP008518 AAEL012519 PHUM125920 GLEAN_06152
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	31126 y1 v1; P{TRiP.JF01599}attP2 8754 w*; SCARΔ37 P{neoFRT}40A/CyO 10523 y1 w67c23; P{lacW}SCARk03107/CyO 36121 y1 sc* v1; P{TRiP.HMS01536}attP40 28390 y1 w*; P{EP}SCARG12874 l(2)06225G12874
Kyoto	104718 w*; P{GawB}SCARNP4622 / CyO 102899 y1 w67c23 ; P{lacW}SCARk13811 / CyO 111156 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}SCARk03107 P{neoFRT}40A/CyO y+
VDRC	v21908 w1118; P{GD11380}v21908/CyO
Genomic Clones ( 2 )
	BACR03D06 BACR20O15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 173 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM03296 SD02991
Other clones	DPiM_SD02991 MIP02773 MIP02973
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL01158 LP11386 RE02412 RE02626 RE04301 RE15948 RE16961 RE17079 RE31512 RE33375 RE33376 RE47456 RE49437 RE51337 RE74840 SD01264 SD02666 SD03496 SD05409 SD10808 SD17421 SD18177 SD19227
Other clones	15971 16235 34373 57718 64977 100058 172546 281501 bs11h11 CK01.56A.F12 CK01.61D.H4 CK01.65A.A10 CK01.170D.F3 CK01.170D.F5 Dmel_dig_009749_0698_1994 Dmel_neb_013876_0414_3096 Dmel_neb_014104_0445_2215 Dmel_neb_015059_0122_2345 EC13120 EK045242 EK095808 EK104822 EK127039 EK133705 EK178611 EK191636 EK222438 EK272551 EK307128 FGM223G03 RP003009863 RP003025130 RP003041771 RP003045179 RP003047706 RP003054539 RP003062499 RP003066074 RP003077387 RP003105996 RP003113510 RP003117357 RP003131947 RP003142754 RP003143102 RP003176863 RP003179272 RP003187967 RP003195316 RP003195508 RP003198370 RP003204334 RP003206239 RP003207236 RP003219917 RP003227239 RP003231855 RP003232162 RP003232398 RP003234671 RP003234839 RP003240381 RP003241114 RP003243683 RP003257006 RP003259511 RP003270994 RP003293205 RP003294132 RP003296217 RP003308228 RP003325179 RP003325460 RP003349099 RP003356114 RP003360516 RP003369450 RP003370010 RP003375375 RP003385870 RP003395752 RP003398273 RP003402633 RP003407204 RP003413472 RP003418320 RP003423038 RP003427171 RP003429237 RP003436863 RP003444559 RP003447245 RP003455436 RP003463521 RP003468591 RP003487973 RP003495349 RP003507058 RP003508269 RP003511040 RP003513344 RP003517066 RP003517434 RP003522493 RP003524372 RP003526214 RP003528059 RP003529463 RP003535310 RP003535573 RP003536788 RP003537070 RP003537391 RP003541263 RP003543090 RP003544968 RP003549907 RP003555420 RP003557066 RP003560495 RP003575092 RP003575823 RP003581219 RP003595335 RP003597992 RP003599559 RP003606397 RP003611080 RP003615091 RP003621004 RP003622160 RP003622288 RP003627519 RP003645516 RP003649610 RP003659135 RP003659499 RP003659576 RP003659906 RP003671049 RP003672720 RP003674202 RP003680585 RP003682384 UUGC0587
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041781 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34519
Antibody Information
	polyclonal (Gautier et al., 2011, Zallen et al., 2002, Stephan et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(2)k03107 l(2)k13811 (Spradling et al., 1999) Source for merge of: SCAR BEST:SD02991 (Rana, 2004.7.8) Source for merge of: SCAR CG4636 (FlyBase, 1996-) Source for merge of: SCAR l(2)k03107 (Zallen et al., 2002)
Additional comments	Source for merge of SCAR CG4636 was sequence comparison (date:000607). (FlyBase, 1996-)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans, Escherichia coli, Staphylococcus aureus and latex beads compared to untreated cells. (Stroschein-Stevenson et al., 2006) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: reduced F-actin and altered cell shape. Kc167 cells show change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) SCAR plays a major role in Arp66B dependent regulation of cell morphology. (Zallen et al., 2002) SCAR function is essential for cytoplasmic organization in the blastoderm, axon development in the central nervous system, egg chamber structure during oogenesis, and adult eye morphology. (Zallen et al., 2002) SCAR may be involved in embryonic central nervous system development. (Schejter et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135633 RefSeq (Proteins) • NP_609477 DDBJ / EMBL / GenBank • AA695688 AAF53042 AAF74194 AAL28407 AAL29127 AF247763 AI531743 AI945364 AQ025718 AQ026072 AW941193 AW944276 AY060859 AY061579 Entrez Gene - A searchable database of RefSeq genes. • 34519 UniProtKB/TrEMBL • Q9VKM2 Q95SC7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding WH2 (IPR003124)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60587 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041781 DroID - A comprehensive database of gene and protein interactions. • FBgn0041781 DRSC - Results from RNAi screens. • FBgn0041781 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041781 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4636-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041781 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34519 InParanoid A subset of ortholog calls from InParanoid. • AAEL012519-PA Aedes aegypti (mosquito) AGAP008518-PA Anopheles gambiae (mosquito) XP_394398.1 Apis mellifera (honey bee) XP_001943697.1 Acyrthosiphon pisum (pea aphid) 34265 Batrachochytrium dendrobatidis (chytrid fungus) 133270 Branchiostoma floridae (lancelet) XP_001902396.1 Brugia malayi (roundworm nematode) BGIBMGA007478-PA Bombyx mori (silk worm) ENSBTAP00000019468 Bos taurus (bovine) CN19054 Caenorhabditis brenneri (small nematode) CBP34983 Caenorhabditis briggsae (nematode) CE36188 Caenorhabditis elegans (worm) ENSCAFP00000017843 Canis familiaris (dog) ENSCINP00000025762 Ciona intestinalis (sea squirt) JA18427 Caenorhabditis japonica (nematode) CPIJ000362 Culex pipens (mosquito) ENSCPOP00000009121 Cavia porcellus (guinea pig) RP25470 Caenorhabditis remanei (nematode) ENSCSAVP00000010971 Ciona savignyi (sedentary tunicate) 219958 Capitella spl (polychaete worm) DDB0191148 Dictyostelium discoideum (amoeba) 308566 Daphnia pulex (daphnia) ENSDARP00000093195 Danio rerio (zebra fish) ENSECAP00000000057 Equus caballus (horse) ENSGACP00000007637 Gymnopilus aculeatus (mushroom) ENSGALP00000027574 Gallus gallus (chicken) 181744 Hypsipyla robusta (cedar shoot borer) ENSP00000370877 Homo sapiens (human) ISCW007639-PA Ixodes scapularis (deer tick) 38487 Monocosta brevicollis (choanoflagellate) ENSMODP00000010952 Monodelphis domestica (gray opossum) ENSMMUP00000006698 Macaca mulatta (rhesus monkey) ENSMUSP00000016143 Mus musculus (house mouse) XP_001607386.1 Nasonia vitripennis (wasp) ENSOANP00000014407 Ornithorynchus anatinus (platypus) ENSORLP00000017542 Oryzias latipes (japanese killifish) LOC_Os01g11040.1 Oryza sativa (asian rice) PHUM004926-PA Pediculus humanus (human body louse) 95614 Physcomitrella patens (moss) ENSPPYP00000005957 Pongo pygmaeus (orangutan) 555676 Populus trichocarpa (black cottonwood) ENSPTRP00000040016 Pan troglodytes (chimpanzee) ENSRNOP00000013117 Rattus norvegicus (norway rat) Smp_078050 Schistosoma mansoni (trematode parasite) XP_001191393.1 Strongylocentrotus purpuratus (purple sea urchin) XP_973241.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021795 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031626 Takifugu rubripes (pufferfish Takifugu) 83641.m00142 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000044664 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/scar1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34519 modMine - Data generated by the modENCODE project. • FBgn0041781 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11656 NV11801 LH18943 ISCW007639 FBgn0235914 FBgn0216895 FBgn0201145 FBgn0195118 FBgn0173680 JGI_V11_308566 FBgn0078325 FBgn0156731 FBgn0143321 FBgn0118244 FBgn0115829 FBgn0092862 CPIJ000362 BGIBMGA007478 ACYPI007366 GB14671 AGAP008518 AAEL012519 PHUM125920 GLEAN_06152
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	BEST:SD02991   CG4636 (Goldstein and Gunawardena, 2000, Rogers et al., 2003, Hollien and Weissman, 2006, Ni et al., 2008, Ni et al., 2011.7.19) DmSCAR (Linardopoulou et al., 2007) D-SCAR (Schejter et al., 2000) Dscar (Bergeret et al., 2008) DWave (Corrigall et al., 2007) dWAVE (Ismail et al., 2009) l(2)k03107 (Zallen et al., 2002, Deal and Cook, 2003.7.11, Spradling et al., 1999, ) l(2)k13811 (Mesilaty-Gross et al., 1999, ) Scar (Vartiainen and Machesky, 2004, Jacinto and Baum, 2003, Lundquist, 2003, Miller, 2002, Kiehart and Franke, 2002, Hudson and Cooley, 2002, Paunola et al., 2002, Schejter et al., 2001, Dickson, 2000.3.23, Chen et al., 2007, Kondylis et al., 2007, Liu et al., 2009, Johnson et al., 2008, Kondylis et al., 2011) scar (Smith and Li, 2004, Bogdan and Klambt, 2003, Li and Baker, 2007, Schäfer et al., 2008, Sens and Chen, 2008, Corrigall et al., 2007, Georgiou et al., 2008, Berger et al., 2008, Lin et al., 2009, Fricke et al., 2009, Cohen et al., 2010, Kondylis et al., 2011, D'Ambrosio and Vale, 2010) SCAR (Hollien and Weissman, 2006, Qurashi et al., 2007, Stroschein-Stevenson et al., 2006, Stuart et al., 2007, Bakal et al., 2007, Richardson and Baylies, 2008, Schäfer et al., 2008, Bakal et al., 2007, Riparbelli et al., 2007, Johnson et al., 2008, Richardson et al., 2007, Biyasheva et al., 2004, Qurashi et al., 2007, Hilger et al., 2009, Robine et al., 2009, Gildor et al., 2009, Serio et al., 2010, Cohen et al., 2010, Liu et al., 2010, Georgiou and Baum, 2010, Picone et al., 2010) SCAR/WAVE (Liu et al., 2010) unnamed (Sardiello and Tripoli, 2000.10.19) Wave (Bogdan et al., 2004, Bogdan et al., 2005) wave (Bogdan and Klambt, 2003, Schäfer et al., 2008, Fricke et al., 2009) WAVE (Strunk et al., 2003, Qurashi et al., 2007, Chen et al., 2007, Richardson and Baylies, 2008, Schäfer et al., 2008, Bogdan et al., 2005, Georgiou et al., 2008, Kondylis et al., 2011, Gohl et al., 2010)
Name Synonym	SCAR   Scar (Rogers et al., 2003) suppressor of cAR (Johnson et al., 2008) Suppressor of cyclic AMP receptor (Gildor et al., 2009)
Secondary FlyBase IDs
	FBgn0021868 FBgn0022228 FBgn0032324 FBgn0046233
References ( 92 )
Generate a list of	All references relating to this gene ( 92 )
List References by type	Research paper  ( 46 ) Supplementary material  ( 9 ) Review  ( 11 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 12 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 )
Recent research papers ( 11 )
	Gautier et al., 2011, J. Cell Sci. 124(20): 3414--3427 Clathrin is required for Scar/Wave-mediated lamellipodium formation. [FBrf0216441] Kondylis et al., 2011, PLoS ONE 6(2): e17173 Identification of ER Proteins Involved in the Functional Organisation of the Early Secretory Pathway in Drosophila Cells by a Targeted RNAi Screen. [FBrf0213167] Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092 Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499] Cohen et al., 2010, Dev. Cell 19(1): 78--89 Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition. [FBrf0211296] D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. [FBrf0212211] Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098 Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions. [FBrf0214990] Gohl et al., 2010, J. Biol. Chem. 285(51): 40171--40179 WAVE Forms Hetero- and Homo-oligomeric Complexes at Integrin Junctions in Drosophila Visualized by Bimolecular Fluorescence Complementation. [FBrf0212496] Lesch et al., 2010, Genetics 186(3): 943--957 A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes. [FBrf0212282] Liu et al., 2010, J. Cell Sci. 123(16): 2708--2716 Tao-1 is a negative regulator of microtubule plus-end growth. [FBrf0211454] Picone et al., 2010, PLoS Biol. 8(11): e1000542 A polarised population of dynamic microtubules mediates homeostatic length control in animal cells. [FBrf0214185] Serio et al., 2010, Cell Host Microbe 7(5): 388--398 Defining a Core Set of Actin Cytoskeletal Proteins Critical for Actin-Based Motility of Rickettsia. [FBrf0210774] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...