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Gene Dmel\Pax

General Information
Symbol	Dmel\Pax	Species	D. melanogaster
Name	Paxillin	Annotation symbol	CG31794
Feature type	protein_coding_gene	FlyBase ID	FBgn0041789
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	CG18576, DPxn37, PDLP, Dpax, CG18061
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	37D5-37D7	Sequence location	2L:19,400,781..19,426,424 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Paxillin is referred to in FlyBase by the symbol Dmel\Pax (CG31794, FBgn0041789). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding. There is experimental evidence that it is involved in the biological process: wing disc development; regulation of Rho GTPase activity; leg disc development. 25 alleles are reported. The phenotype of these alleles is annotated with: wing. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Zinc finger, LIM-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626624_s_at completely aligns to an exonic region of only a subset of 5 of the 6 FlyBase-annotated transcript isoforms of Pax. Gene sequence location is 2L:19400781..19426424.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Bakal et al., 2007, Science 316(5832): 1753--1756
FB2012_01	References Cunha et al., 2010, PLoS Genet. 6: e1001014 Controlled Vocabulary Terms P-stage larval stage wandering third instar larval stage third instar - uncleared gut stage early third instar larval stage pharate adult stage P14 prepupal stage P3 pharate adult stage P15(ii) embryonic/larval muscle system third instar - partially cleared gut stage ubiquitous pharate adult stage P13 pharate adult stage P11 third instar - cleared gut stage third instar larval stage L2 prepupal stage P4(i) somatic muscle primordium pharate adult stage pharate adult stage P15(i) pupal stage P5(i) pharate adult stage P12(i) prepupal stage P2 embryonic/larval somatic muscle prepupal stage P4 pharate adult stage P15 pharate adult stage P12(ii) prepupal stage P4(ii) pharate adult stage P9 third instar larval stage L1 dorsal closure stage pharate adult stage P10 second instar larval stage pupal stage P5 faint pupal stage pharate adult stage P8 hypodermal muscle of head embryonic stage muscle tendon junction adult stage prepupal stage P1 pharate adult stage P12 intense prepupal stage segment boundary segmentally repeated pupal stage P6 first instar larval stage pharate adult stage P11(i) pupal stage P7 embryonic stage 17 pupal stage P5(ii) pharate adult stage P11(ii) Sequence features HFA01703 BKN46540 HFA02651 BKN29242 HFA02652
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37D5-37D7   Limits computationally determined from genome sequence between P{EP}dntEP2158 and P{EP}EP623&P{PZ}spi01068
Experimentally Determined Cytological Location
Cytogenetic map Notes References 37D-37D   (determined by in situ hybridisation)   (Wheeler and Hynes, 2001) 37D-37D     (Wheeler, 2000.10.13)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pax for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pax-RA FBtr0081213  NM_078877   2216   581 Pax-RB FBtr0081212  NM_165295   2043   556 Pax-RC FBtr0081210  NM_165293   2205   557 Pax-RD FBtr0081214  NM_165296   1379   197 Pax-RF FBtr0081211  NM_165294   2444   581 Pax-RG FBtr0100449  NM_001038824   2580   581 Pax-RH FBtr0306598     2097   563 Pax-RI FBtr0306599     2208   581
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pax-PA   FBpp0080754   64.7   581   6.71     NP_523601   AAF53792 Pax-PB   FBpp0080753   61.9   556   6.69     NP_724185   AAF53791 Pax-PC   FBpp0080751   62.0   557   6.50     NP_724183   AAN11037 Pax-PD   FBpp0080755   22.4   197   6.48     NP_724186   AAN11039 Pax-PF   FBpp0080752   64.7   581   6.96     NP_724184   AAN11038 Pax-PG   FBpp0099871   64.7   581   6.96     NP_001033913   AAN11040 Pax-PH   FBpp0297553   62.7   563   6.50       Pax-PI   FBpp0297554   64.7   581   6.71
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, LIM-type (IPR001781)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142016   AA246304   AA441556   AA540969   AA696001   AA696713   AE014134 AAF53791   AE014134 AAF53792   AE014134 AAN11037   AE014134 AAN11038   AE014134 AAN11039   AE014134 AAN11040   AB048194 BAB33159   AB056465 BAB62005   AF312926 AAG34161   AI107399   AI134353   AI238500   AI296077   AI297743   AI297955   AI387002   AI387065   AI387665   AI389500   AI402318   AI406138   AI513528   AI514127   AI533094   AW944386   AY122248 AAM52760   BG637818   BG638116   BI163040   BI164898   BI168076   BI168079   BI169554   BI173848   BI215191   BI228839   BI229343   BI231390   BI241359   BI241437   BI353223   BI354972   BI361385   BI366855   BI371241   BI375992   BI574443   BI592623   BI610216   BI613333   BI627544   BP559003   BP559004   BQ103341   BT088784   BT100235   BT100283   BT120137   BT120186   BZ748787   CL943504   CO154032   CO156968   CO188412   CO263425   CO283726   CO285489   CO298305   CO298655   CO302144   CO304283   CO313086   CO315459   CO317231   CO323029   CO323533   CO324856   CO327218   CO335316   CO341794   CZ468084   CZ468085   CZ471153   CZ471208   CZ471231   CZ472034   CZ472035   CZ472401   CZ475258   CZ475259   CZ476657   CZ486528   CZ486529   EC052376   EC084421   EC088030   EC201631   EC205942   EC222272   EC223627   EC225576   EC226722   EC228910   EC231736   EC235099   EC235306   EC245922   EC248793   EC248992   EC252733   EC252818   EC254490   EC260927   EC263127   EC265852
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q2PDT4 Q8INW7 Q8MQX3 Q966T5 Q9BPQ9 Q9GSE0 Q9VIX2 Q9VIX3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism | ubiquitous & uniform   (Yagi et al., 2001) Comment:2.4 kB isoform; maternally deposited embryonic stage 6 -- 12   organism | ubiquitous   (Yagi et al., 2001) Comment:2.4 kB isoform embryonic stage 10   hindgut proper primordium   (Wheeler and Hynes, 2001) embryonic stage 11   proctodeum   (Wheeler and Hynes, 2001) embryonic stage 11 -- 12   cardiogenic mesoderm   (Wheeler and Hynes, 2001) embryonic stage 13 -- 15   somatic muscle primordium | segmentally repeated   • muscle tendon junction (Yagi et al., 2001) Comment:2.4 kB isoform somatic muscle primordium | segmentally repeated   (Yagi et al., 2001) Comment:1.4 kB isoform embryonic stage 13 -- 16   dorsal vessel primordium   (Wheeler and Hynes, 2001) embryonic pericardial cell   (Wheeler and Hynes, 2001) embryonic stage 16   hindgut visceral muscle primordium   (Wheeler and Hynes, 2001) embryonic/larval hindgut   (Wheeler and Hynes, 2001) embryonic/larval midgut   (Wheeler and Hynes, 2001) embryonic/larval proventriculus   (Wheeler and Hynes, 2001) pharyngeal bars   (Wheeler and Hynes, 2001) embryonic stage 16 -- 17   embryonic/larval muscle system | segmentally repeated   • muscle tendon junction (Yagi et al., 2001) Comment:2.4 kB isoform embryonic/larval muscle system | segmentally repeated   (Yagi et al., 2001) Comment:1.4 kB isoform northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Yagi et al., 2001) Comment:2.4 kB isoform embryonic stage 12 -- 16   organism | faint   (Yagi et al., 2001) Comment:1.4 kB isoform embryonic stage 17 -- second instar larval stage   organism | intense   (Yagi et al., 2001) Comment:1.4 kB isoform third instar larval stage   organism | faint   (Yagi et al., 2001) Comment:1.4 kB isoform pharate adult stage   organism | intense   (Yagi et al., 2001) Comment:1.4 kB isoform adult stage   organism   (Yagi et al., 2001) Comment:1.4 kB isoform
Additional Descriptive Data
	Northern analysis using a probe specific to long (~2.4 kB) isoforms are expressed from early embryogenesis with expression peaks at embryonic stage 17--first larval instar and in pharate adults. A probe spefic to only Pax-RD (1.4 kB) is expressed faintly at 8-16 hr AEL and at the third larval instar, at a moderate level in male and female adults, very strongly from 16 hr AEL through the second larval instar and in pharate adults, and not expressed 0-8 hr AEL or in prepupae. (Yagi et al., 2001)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16   embryonic/larval somatic muscle   • muscle tendon junction (Yagi et al., 2001) Comment:long isoform embryonic/larval somatic muscle | segment boundary   (Yagi et al., 2001) Comment:short isoform hypodermal muscle of head   (Yagi et al., 2001) Comment:short isoform third instar larval stage   muscle fiber & muscle attachment site | vicinity of   (Subramanian et al., 2003) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 15   organism   (Wheeler and Hynes, 2001) Comment:0-12 hr AEL   S2 cell-line   (Wheeler and Hynes, 2001) embryo-derived cell-line   (Wheeler and Hynes, 2001) Comment:Kc0 cells
Additional Descriptive Data
	The Pax protein is enriched at the muscle-tendon junction in third instar larvae and is found primarily in muscle cell in the region near the membrane. (Subramanian et al., 2003) In cultured NIH-3T3 cells, fluorescently-tagged Pax-PD short isoform protein localizes along actin bundles, while the long isoform is localized to focal adhesions. In the embyronic/larval muscle system of late embryos, the Pax long isoform is localized to muscle tendon junctions, while the short isoform has particularly strong staining along segment boundaries in the somatic muscle system. (Yagi et al., 2001)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041789    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041789 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041789 expression level Developmental Stage   Expression Level embryo 00-02hr    2893 embryo 02-04hr    3607 embryo 04-06hr    792 embryo 06-08hr    1086 embryo 08-10hr    2181 embryo 10-12hr    2608 embryo 12-14hr    3256 embryo 14-16hr    6929 embryo 16-18hr    8613 embryo 18-20hr    19135 embryo 20-22hr    33549 embryo 22-24hr    24783 larva L1    13307 larva L2    10761 larva L3 12hr old    16249 larva L3 puffstage 1-2    9616 larva L3 puffstage 3-6    5228 larva L3 puffstage 7-9    3843 white prepupae new    3857 white prepupae 12hr    5535 white prepupae 24hr    2020 pupae 2d postWPP    2570 pupae 3d postWPP    5261 pupae 4d postWPP    28191 adult male 01day    5706 adult male 05day    6090 adult male 30day    5045 adult female 01day    5553 adult female 05day    2923 adult female 30day    2896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2893) embryo 02-04hr  (3607) embryo 04-06hr  (792) embryo 06-08hr  (1086) embryo 08-10hr  (2181) embryo 10-12hr  (2608) embryo 12-14hr  (3256) embryo 14-16hr  (6929) embryo 16-18hr  (8613) embryo 18-20hr  (19135) embryo 20-22hr  (33549) embryo 22-24hr  (24783) larva L1  (13307) larva L2  (10761) larva L3 12hr old  (16249) larva L3 puffstage 1-2  (9616) larva L3 puffstage 3-6  (5228) larva L3 puffstage 7-9  (3843) white prepupae new  (3857) white prepupae 12hr  (5535) white prepupae 24hr  (2020) pupae 2d postWPP  (2570) pupae 3d postWPP  (5261) pupae 4d postWPP  (28191) adult male 01day  (5706) adult male 05day  (6090) adult male 30day  (5045) adult female 01day  (5553) adult female 05day  (2923) adult female 30day  (2896) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2893) embryo 02-04hr  (3607) embryo 04-06hr    792 embryo 06-08hr    1086 embryo 08-10hr  (2181) embryo 10-12hr  (2608) embryo 12-14hr  (3256) embryo 14-16hr  (6929) embryo 16-18hr  (8613) embryo 18-20hr  (19135) embryo 20-22hr  (33549) embryo 22-24hr  (24783) larva L1  (13307) larva L2  (10761) larva L3 12hr old  (16249) larva L3 puffstage 1-2  (9616) larva L3 puffstage 3-6  (5228) larva L3 puffstage 7-9  (3843) white prepupae new  (3857) white prepupae 12hr  (5535) white prepupae 24hr  (2020) pupae 2d postWPP  (2570) pupae 3d postWPP  (5261) pupae 4d postWPP  (28191) adult male 01day  (5706) adult male 05day  (6090) adult male 30day  (5045) adult female 01day  (5553) adult female 05day  (2923) adult female 30day  (2896) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2893 embryo 02-04hr    3607 embryo 04-06hr    792 embryo 06-08hr    1086 embryo 08-10hr    2181 embryo 10-12hr    2608 embryo 12-14hr    3256 embryo 14-16hr    6929 embryo 16-18hr    8613 embryo 18-20hr  (19135) embryo 20-22hr  (33549) embryo 22-24hr  (24783) larva L1  (13307) larva L2  10761 larva L3 12hr old  (16249) larva L3 puffstage 1-2    9616 larva L3 puffstage 3-6    5228 larva L3 puffstage 7-9    3843 white prepupae new    3857 white prepupae 12hr    5535 white prepupae 24hr    2020 pupae 2d postWPP    2570 pupae 3d postWPP    5261 pupae 4d postWPP  (28191) adult male 01day    5706 adult male 05day    6090 adult male 30day    5045 adult female 01day    5553 adult female 05day    2923 adult female 30day    2896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2893 embryo 02-04hr    3607 embryo 04-06hr    792 embryo 06-08hr    1086 embryo 08-10hr    2181 embryo 10-12hr    2608 embryo 12-14hr    3256 embryo 14-16hr    6929 embryo 16-18hr    8613 embryo 18-20hr    19135 embryo 20-22hr    33549 embryo 22-24hr    24783 larva L1    13307 larva L2    10761 larva L3 12hr old    16249 larva L3 puffstage 1-2    9616 larva L3 puffstage 3-6    5228 larva L3 puffstage 7-9    3843 white prepupae new    3857 white prepupae 12hr    5535 white prepupae 24hr    2020 pupae 2d postWPP    2570 pupae 3d postWPP    5261 pupae 4d postWPP    28191 adult male 01day    5706 adult male 05day    6090 adult male 30day    5045 adult female 01day    5553 adult female 05day    2923 adult female 30day    2896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041789 expression level Developmental Stage   Expression Level embryo 00-02hr    2893 embryo 02-04hr    3607 embryo 04-06hr    792 embryo 06-08hr    1086 embryo 08-10hr    2181 embryo 10-12hr    2608 embryo 12-14hr    3256 embryo 14-16hr    6929 embryo 16-18hr    8613 embryo 18-20hr    19135 embryo 20-22hr    33549 embryo 22-24hr    24783 larva L1    13307 larva L2    10761 larva L3 12hr old    16249 larva L3 puffstage 1-2    9616 larva L3 puffstage 3-6    5228 larva L3 puffstage 7-9    3843 white prepupae new    3857 white prepupae 12hr    5535 white prepupae 24hr    2020 pupae 2d postWPP    2570 pupae 3d postWPP    5261 pupae 4d postWPP    28191 adult male 01day    5706 adult male 05day    6090 adult male 30day    5045 adult female 01day    5553 adult female 05day    2923 adult female 30day    2896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2893) embryo 02-04hr  (3607) embryo 04-06hr  (792) embryo 06-08hr  (1086) embryo 08-10hr  (2181) embryo 10-12hr  (2608) embryo 12-14hr  (3256) embryo 14-16hr  (6929) embryo 16-18hr  (8613) embryo 18-20hr  (19135) embryo 20-22hr  (33549) embryo 22-24hr  (24783) larva L1  (13307) larva L2  (10761) larva L3 12hr old  (16249) larva L3 puffstage 1-2  (9616) larva L3 puffstage 3-6  (5228) larva L3 puffstage 7-9  (3843) white prepupae new  (3857) white prepupae 12hr  (5535) white prepupae 24hr  (2020) pupae 2d postWPP  (2570) pupae 3d postWPP  (5261) pupae 4d postWPP  (28191) adult male 01day  (5706) adult male 05day  (6090) adult male 30day  (5045) adult female 01day  (5553) adult female 05day  (2923) adult female 30day  (2896) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2893) embryo 02-04hr  (3607) embryo 04-06hr    792 embryo 06-08hr    1086 embryo 08-10hr  2181 embryo 10-12hr  (2608) embryo 12-14hr  (3256) embryo 14-16hr  (6929) embryo 16-18hr  (8613) embryo 18-20hr  (19135) embryo 20-22hr  (33549) embryo 22-24hr  (24783) larva L1  (13307) larva L2  (10761) larva L3 12hr old  (16249) larva L3 puffstage 1-2  (9616) larva L3 puffstage 3-6  (5228) larva L3 puffstage 7-9  (3843) white prepupae new  (3857) white prepupae 12hr  (5535) white prepupae 24hr  2020 pupae 2d postWPP  (2570) pupae 3d postWPP  (5261) pupae 4d postWPP  (28191) adult male 01day  (5706) adult male 05day  (6090) adult male 30day  (5045) adult female 01day  (5553) adult female 05day  (2923) adult female 30day  (2896) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2893 embryo 02-04hr    3607 embryo 04-06hr    792 embryo 06-08hr    1086 embryo 08-10hr    2181 embryo 10-12hr    2608 embryo 12-14hr    3256 embryo 14-16hr    6929 embryo 16-18hr    8613 embryo 18-20hr  19135 embryo 20-22hr  (33549) embryo 22-24hr  (24783) larva L1  13307 larva L2  10761 larva L3 12hr old  16249 larva L3 puffstage 1-2    9616 larva L3 puffstage 3-6    5228 larva L3 puffstage 7-9    3843 white prepupae new    3857 white prepupae 12hr    5535 white prepupae 24hr    2020 pupae 2d postWPP    2570 pupae 3d postWPP    5261 pupae 4d postWPP  (28191) adult male 01day    5706 adult male 05day    6090 adult male 30day    5045 adult female 01day    5553 adult female 05day    2923 adult female 30day    2896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2893 embryo 02-04hr    3607 embryo 04-06hr    792 embryo 06-08hr    1086 embryo 08-10hr    2181 embryo 10-12hr    2608 embryo 12-14hr    3256 embryo 14-16hr    6929 embryo 16-18hr    8613 embryo 18-20hr    19135 embryo 20-22hr    33549 embryo 22-24hr    24783 larva L1    13307 larva L2    10761 larva L3 12hr old    16249 larva L3 puffstage 1-2    9616 larva L3 puffstage 3-6    5228 larva L3 puffstage 7-9    3843 white prepupae new    3857 white prepupae 12hr    5535 white prepupae 24hr    2020 pupae 2d postWPP    2570 pupae 3d postWPP    5261 pupae 4d postWPP    28191 adult male 01day    5706 adult male 05day    6090 adult male 30day    5045 adult female 01day    5553 adult female 05day    2923 adult female 30day    2896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041789    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041789 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041789 expression level Tissue   Expression Level Larval Central Nervous System    163.475 Larval Midgut    352.1 Larval Hindgut    593.2 Larval Malpighian Tubules    167.7 Larval Fat Body    81.1 Larval Salivary Gland    427.3 Larval Trachea    246 Larval Carcass    501.775 Adult Head    74.2 Adult Eye    61.725 Adult Brain    83.3 Adult Thoracic-Abdominal Ganglion    138.4 Adult Crop    233.1 Adult Midgut    107.5 Adult Hindgut    239.7 Adult Malpighian Tubules    84.8 Adult Fat Body    105.9 Adult Salivary Gland    372.6 Adult Heart    121.55 Adult VirginFemale Spermatheca    45.1 Adult InseminatedFemale Spermatheca    76.9 Adult Ovary    81.1 Adult Testis    42.4 Adult Male Accessory Gland    135.9 Adult Carcass    244.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    163.475 Larval Midgut    352.1 Larval Hindgut  (593.2) Larval Malpighian Tubules    167.7 Larval Fat Body    81.1 Larval Salivary Gland    427.3 Larval Trachea    246 Larval Carcass  501.775 Adult Head    74.2 Adult Eye    61.725 Adult Brain    83.3 Adult Thoracic-Abdominal Ganglion    138.4 Adult Crop    233.1 Adult Midgut    107.5 Adult Hindgut    239.7 Adult Malpighian Tubules    84.8 Adult Fat Body    105.9 Adult Salivary Gland    372.6 Adult Heart    121.55 Adult VirginFemale Spermatheca    45.1 Adult InseminatedFemale Spermatheca    76.9 Adult Ovary    81.1 Adult Testis    42.4 Adult Male Accessory Gland    135.9 Adult Carcass    244.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    163.475 Larval Midgut    352.1 Larval Hindgut    593.2 Larval Malpighian Tubules    167.7 Larval Fat Body    81.1 Larval Salivary Gland    427.3 Larval Trachea    246 Larval Carcass    501.775 Adult Head    74.2 Adult Eye    61.725 Adult Brain    83.3 Adult Thoracic-Abdominal Ganglion    138.4 Adult Crop    233.1 Adult Midgut    107.5 Adult Hindgut    239.7 Adult Malpighian Tubules    84.8 Adult Fat Body    105.9 Adult Salivary Gland    372.6 Adult Heart    121.55 Adult VirginFemale Spermatheca    45.1 Adult InseminatedFemale Spermatheca    76.9 Adult Ovary    81.1 Adult Testis    42.4 Adult Male Accessory Gland    135.9 Adult Carcass    244.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    163.475 Larval Midgut    352.1 Larval Hindgut    593.2 Larval Malpighian Tubules    167.7 Larval Fat Body    81.1 Larval Salivary Gland    427.3 Larval Trachea    246 Larval Carcass    501.775 Adult Head    74.2 Adult Eye    61.725 Adult Brain    83.3 Adult Thoracic-Abdominal Ganglion    138.4 Adult Crop    233.1 Adult Midgut    107.5 Adult Hindgut    239.7 Adult Malpighian Tubules    84.8 Adult Fat Body    105.9 Adult Salivary Gland    372.6 Adult Heart    121.55 Adult VirginFemale Spermatheca    45.1 Adult InseminatedFemale Spermatheca    76.9 Adult Ovary    81.1 Adult Testis    42.4 Adult Male Accessory Gland    135.9 Adult Carcass    244.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041789 expression level Tissue   Expression Level Larval Central Nervous System    163.475 Larval Midgut    352.1 Larval Hindgut    593.2 Larval Malpighian Tubules    167.7 Larval Fat Body    81.1 Larval Salivary Gland    427.3 Larval Trachea    246 Larval Carcass    501.775 Adult Head    74.2 Adult Eye    61.725 Adult Brain    83.3 Adult Thoracic-Abdominal Ganglion    138.4 Adult Crop    233.1 Adult Midgut    107.5 Adult Hindgut    239.7 Adult Malpighian Tubules    84.8 Adult Fat Body    105.9 Adult Salivary Gland    372.6 Adult Heart    121.55 Adult VirginFemale Spermatheca    45.1 Adult InseminatedFemale Spermatheca    76.9 Adult Ovary    81.1 Adult Testis    42.4 Adult Male Accessory Gland    135.9 Adult Carcass    244.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    163.475 Larval Midgut    352.1 Larval Hindgut  593.2 Larval Malpighian Tubules    167.7 Larval Fat Body    81.1 Larval Salivary Gland    427.3 Larval Trachea    246 Larval Carcass  501.775 Adult Head    74.2 Adult Eye    61.725 Adult Brain    83.3 Adult Thoracic-Abdominal Ganglion    138.4 Adult Crop    233.1 Adult Midgut    107.5 Adult Hindgut    239.7 Adult Malpighian Tubules    84.8 Adult Fat Body    105.9 Adult Salivary Gland    372.6 Adult Heart    121.55 Adult VirginFemale Spermatheca    45.1 Adult InseminatedFemale Spermatheca    76.9 Adult Ovary    81.1 Adult Testis    42.4 Adult Male Accessory Gland    135.9 Adult Carcass    244.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    163.475 Larval Midgut    352.1 Larval Hindgut    593.2 Larval Malpighian Tubules    167.7 Larval Fat Body    81.1 Larval Salivary Gland    427.3 Larval Trachea    246 Larval Carcass    501.775 Adult Head    74.2 Adult Eye    61.725 Adult Brain    83.3 Adult Thoracic-Abdominal Ganglion    138.4 Adult Crop    233.1 Adult Midgut    107.5 Adult Hindgut    239.7 Adult Malpighian Tubules    84.8 Adult Fat Body    105.9 Adult Salivary Gland    372.6 Adult Heart    121.55 Adult VirginFemale Spermatheca    45.1 Adult InseminatedFemale Spermatheca    76.9 Adult Ovary    81.1 Adult Testis    42.4 Adult Male Accessory Gland    135.9 Adult Carcass    244.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    163.475 Larval Midgut    352.1 Larval Hindgut    593.2 Larval Malpighian Tubules    167.7 Larval Fat Body    81.1 Larval Salivary Gland    427.3 Larval Trachea    246 Larval Carcass    501.775 Adult Head    74.2 Adult Eye    61.725 Adult Brain    83.3 Adult Thoracic-Abdominal Ganglion    138.4 Adult Crop    233.1 Adult Midgut    107.5 Adult Hindgut    239.7 Adult Malpighian Tubules    84.8 Adult Fat Body    105.9 Adult Salivary Gland    372.6 Adult Heart    121.55 Adult VirginFemale Spermatheca    45.1 Adult InseminatedFemale Spermatheca    76.9 Adult Ovary    81.1 Adult Testis    42.4 Adult Male Accessory Gland    135.9 Adult Carcass    244.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    74.2   NA  Eye    61.725   NA  Brain    83.3   163.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    138.4   NA  Crop    233.1   352.1  Midgut    107.5   593.2  Hindgut    239.7   167.7  Malpighian Tubules    84.8   81.1  Fat Body    105.9   427.3  Salivary Gland    372.6   NA  Heart    121.55   246  Trachea    NA   NA  VirginFemale Spermatheca    45.1   NA  InseminatedFemale Spermatheca    76.9   NA  Ovary    81.1   NA  Testis    42.4   NA  Male Accessory Gland    135.9   501.775  Carcass    244.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041789 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31794-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pax Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage | heat sensitive, with Scer\GAL4hs.PB PaxScer\UAS.cCa lethal | pupal stage | heat sensitive, with Scer\GAL4hs.PB PaxScer\UAS.cCa viable PaxEY11633 viable, with Scer\GAL4pnr-MD237 PaxGD10368 Sterility Allele fertile PaxEY11633 Other Phenotypes Allele visible | heat sensitive, with Scer\GAL4hs.PB PaxScer\UAS.cCa Phenotype manifest in Allele egg chamber | conditional, with Scer\GAL4hs.PU PaxScer\UAS.T:Avic\GFP embryonic/larval epidermis | heat sensitive, with Scer\GAL4hs.PB PaxScer\UAS.cCa leg | heat sensitive, with Scer\GAL4hs.PB PaxScer\UAS.cCa wing, with Scer\GAL432B PaxScer\UAS.cCa wing, with Scer\GAL4en-e16E PaxScer\UAS.cCa wing | heat sensitive, with Scer\GAL4hs.PB PaxScer\UAS.cCa wing vein | ectopic | heat sensitive, with Scer\GAL4hs.PB PaxScer\UAS.cCa
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of Pax Class Mutagen Stocks Known lesion Paxc02636 piggyBac transposase 1 -- Paxc06996 piggyBac transposase 1 -- Paxd01111 P-element activity 1 -- Paxd06639 P-element activity 1 -- PaxEY00742 P-element activity 1 -- PaxEY02020 P-element activity 1 -- PaxEY11633 P-element activity 1 -- Paxf03922 piggyBac transposase 1 -- PaxMI03088 1 -- Paxc07057 piggyBac transposase 0 -- Paxc07088 piggyBac transposase 0 -- PaxCPTI000161 piggyBac transposase 0 Yes PaxCPTI002277 piggyBac transposase 0 Yes Paxd01724 P-element activity 0 -- Paxd03585 0 -- Paxd05918 0 -- Paxd09283 P-element activity 0 -- PaxE136 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pax Class Mutagen Stocks Known lesion PaxGD10368 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PaxJF03111 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PaxKK109242 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PaxdsRNA.hs in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes PaxGMR.PC in vitro construct - regulatory fusion 0 Yes PaxScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes PaxScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7075 (Ryder, 2004.4.26)
Partially disrupted in	Df(2L)E136 (Tanji et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10368} NA P{KK109242} NA P{TRiP.JF03111} NA P{UAS-Pax.C} NA P{UAS-Pax.GFP} NA heat-shock construct P{UAS-Pax.IR} NA characterization construct P{GMR-Pax.C} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}PaxEY00742 NA P{EPgy2}PaxEY02020 NA P{EPgy2}PaxEY11633 NA P{XP}Paxd01111 NA P{XP}Paxd01724 NA P{XP}Paxd03585 NA P{XP}Paxd05918 NA P{XP}Paxd06639 NA P{XP}Paxd09283 NA miscellaneous insertions Mi{MIC}PaxMI03088 NA PBac{602.P.SVS-1}PaxCPTI000161 NA PBac{681.P.FSVS-1}PaxCPTI002277 NA PBac{PB}Paxc02636 NA PBac{PB}Paxc06996 NA PBac{PB}Paxc07057 NA PBac{PB}Paxc07088 NA PBac{WH}Paxf03922 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
leg disc development inferred from mutant phenotype (Chen et al., 2005) regulation of Rho GTPase activity inferred from genetic interaction with Rac1 (Chen et al., 2005) inferred from genetic interaction with Rho1 (Chen et al., 2005) wing disc development inferred from mutant phenotype (Chen et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR001781 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cytoskeletal anchoring at plasma membrane inferred from sequence or structural similarity (Hynes and Zhao, 2000)
Cellular Component
CV term Evidence References
focal adhesion inferred from sequence or structural similarity (Hynes and Zhao, 2000) non-traceable author statement (Wheeler, 2000.10.13)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pax allele Gene References unspecified Ret (Read et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61195 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041789 DroID - A comprehensive database of gene and protein interactions. • FBgn0041789 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35215
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15196 Dere\GG21635 Dgri\GH13469 Dmoj\GI17221 Dper\GL21108 Dpse\GA16481 Dsec\GM17013 Dsim\GD21763 Dvir\GJ17978 Dwil\GK23838 Dyak\GE12653
Curated drosophilid orthologs	Dpse\GA16481
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000339-PA Aedes aegypti (mosquito) AGAP008532-PA Anopheles gambiae (mosquito) XP_624308.2 Apis mellifera (honey bee) 273563 Branchiostoma floridae (lancelet) BGIBMGA002788-PA Bombyx mori (silk worm) ENSBTAP00000024101 Bos taurus (bovine) CAL0005764 Candida albicans (a form of yeast) CN11151 Caenorhabditis brenneri (small nematode) ENSCAFP00000024859 Canis familiaris (dog) ENSCINP00000010999 Ciona intestinalis (sea squirt) JA14911 Caenorhabditis japonica (nematode) CPIJ003871 Culex pipens (mosquito) ENSCPOP00000000362 Cavia porcellus (guinea pig) ENSCSAVP00000018741 Ciona savignyi (sedentary tunicate) 107291 Capitella spl (polychaete worm) DDB0185208 Dictyostelium discoideum (amoeba) ENSDARP00000080428 Danio rerio (zebra fish) ENSECAP00000012610 Equus caballus (horse) ENSGACP00000016891 Gymnopilus aculeatus (mushroom) ENSGALP00000011713 Gallus gallus (chicken) ENSP00000378332 Homo sapiens (human) ISCW009899-PA Ixodes scapularis (deer tick) 187724 Lottia gigantea (owl limpet) ENSMODP00000037546 Monodelphis domestica (gray opossum) ENSMMUP00000001196 Macaca mulatta (rhesus monkey) ENSMUSP00000083709 Mus musculus (house mouse) ENSOANP00000010414 Ornithorynchus anatinus (platypus) ENSORLP00000018629 Oryzias latipes (japanese killifish) PHUM005071-PA Pediculus humanus (human body louse) ENSPPYP00000008706 Pongo pygmaeus (orangutan) ENSPTRP00000047049 Pan troglodytes (chimpanzee) ENSRNOP00000001520 Rattus norvegicus (norway rat) Smp_157310 Schistosoma mansoni (trematode parasite) XP_780574.2 Strongylocentrotus purpuratus (purple sea urchin) 13161 Trichoplax adhaerens (metazoa) XP_969819.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013937 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041388 Takifugu rubripes (pufferfish Takifugu) 88026.m00145 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000026649 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50151 LH23026 ISCW009899 FBgn0230380 FBgn0225800 FBgn0205145 FBgn0193184 FBgn0171925 JGI_V11_306277 FBgn0076496 FBgn0158703 FBgn0139965 FBgn0120945 FBgn0113813 FBgn0092221 CPIJ003871 BGIBMGA002788 ACYPI003783 GB19612 AGAP008532 AAEL000339 PB24173 PHUM437870 GLEAN_10609
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	28695 y1 v1; P{TRiP.JF03111}attP2 36191 y1 w*; Mi{MIC}PaxMI03088 15313 y1 w67c23; P{EPgy2}PaxEY00742 15849 y1 w67c23; P{EPgy2}PaxEY02020 20812 y1 w67c23; P{EPgy2}PaxEY11633
Harvard	- P{XP}Paxd01111 - P{XP}Paxd06639 - PBac{PB}Paxc02636 - PBac{PB}Paxc06996 - PBac{WH}Paxf03922
VDRC	v107789 P{KK109242}VIE-260B v25853 w1118; P{GD10368}v25853
Genomic Clones ( 2 )
	BACR27M12 BACR28G24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 88 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD06038 SD04793
Other clones	DPiM_FI11475 FI11475 FI13101 IP18656 MIP15702
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04536 GH11793 GH14552 GH17409 GH17491 GH18249 GH20693 GH21359 GH26344 GH26653 GH27188 GM04891 GM08229 GM22723 GM29096 LD20184 LP09884 LP12113 LP12415 RE02336 RE04665 RE08618 RE08621 RE10764 RE16968 RE21451 RE21531 RE26486 RE27108 RE38410 RE38510 RE45575 RE52481 RE58092 RE63911 RH10365 RH15253 RH23478 RH42467 RH68888
Other clones	34548 41563 55555 63738 63809 66887 79371 106180 121649 214285.26 214409.33 214507.31 523065 CK01.7B.C11 CK01.17B.E6 CK01.126B.F7 CK00121 EC052376 EK040032 EK088502 EK164161 EK169103 EK172722 EK173434 EK183238 EK189529 EK190725 EK195020 EK231262 EK244250 EK261535 EK267404 EN03337 EN09656 EN10014 EP06463 EP13153 FGM318C09 LD05166 LD16533 UUGC0744
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041789 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35215
Antibody Information
	polyclonal (Chen et al., 2005, Yagi et al., 2001)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Paxillin CG18061 (FlyBase, 1996-) Source for merge of: Paxillin CG18576 (Hynes and Zhao, 2000, FlyBase, 1996-)
Additional comments	Annotations CG18061, CG18576 merged as CG31794 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of Paxillin CG18061 was sequence comparison (date:010307). (FlyBase, 1996-) Source for merge of Paxillin CG18576 was sequence comparison (date:001128). (FlyBase, 1996-)
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Pilot et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) snmRNA:359 is derived from the 3' UTR of Pax. (Yuan et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078877 NM_165293 NM_165294 NM_165295 NM_165296 NM_001038824 RefSeq (Proteins) • NP_523601 NP_724183 NP_724184 NP_724185 NP_724186 NP_001033913 DDBJ / EMBL / GenBank • AAF53791 AAF53791.2 AAF53792 AAF53792.3 AAG34161 AAM52760 AAN11037 AAN11037.1 AAN11038 AAN11038.1 AAN11039 AAN11039.1 AAN11040 AAN11040.1 AB048194 AB056465 AF312926 AI533094 AW944386 AY122248 BAB33159 BAB62005 BZ748787 CL943504 CZ468084 CZ468085 CZ471153 CZ471208 CZ471231 CZ472034 CZ472035 CZ472401 CZ475258 CZ475259 CZ476657 CZ486528 CZ486529 Entrez Gene - A searchable database of RefSeq genes. • 35215 UniProtKB/TrEMBL • Q2PDT4 Q8INW7 Q8MQX3 Q9BPQ9 Q9GSE0 Q9VIX2 Q9VIX3 Q966T5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, LIM-type (IPR001781)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61195 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0041789 DroID - A comprehensive database of gene and protein interactions. • FBgn0041789 DRSC - Results from RNAi screens. • FBgn0041789 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041789 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31794-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041789 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35215 InParanoid A subset of ortholog calls from InParanoid. • AAEL000339-PA Aedes aegypti (mosquito) AGAP008532-PA Anopheles gambiae (mosquito) XP_624308.2 Apis mellifera (honey bee) 273563 Branchiostoma floridae (lancelet) BGIBMGA002788-PA Bombyx mori (silk worm) ENSBTAP00000024101 Bos taurus (bovine) CAL0005764 Candida albicans (a form of yeast) CN11151 Caenorhabditis brenneri (small nematode) ENSCAFP00000024859 Canis familiaris (dog) ENSCINP00000010999 Ciona intestinalis (sea squirt) JA14911 Caenorhabditis japonica (nematode) CPIJ003871 Culex pipens (mosquito) ENSCPOP00000000362 Cavia porcellus (guinea pig) ENSCSAVP00000018741 Ciona savignyi (sedentary tunicate) 107291 Capitella spl (polychaete worm) DDB0185208 Dictyostelium discoideum (amoeba) ENSDARP00000080428 Danio rerio (zebra fish) ENSECAP00000012610 Equus caballus (horse) ENSGACP00000016891 Gymnopilus aculeatus (mushroom) ENSGALP00000011713 Gallus gallus (chicken) ENSP00000378332 Homo sapiens (human) ISCW009899-PA Ixodes scapularis (deer tick) 187724 Lottia gigantea (owl limpet) ENSMODP00000037546 Monodelphis domestica (gray opossum) ENSMMUP00000001196 Macaca mulatta (rhesus monkey) ENSMUSP00000083709 Mus musculus (house mouse) ENSOANP00000010414 Ornithorynchus anatinus (platypus) ENSORLP00000018629 Oryzias latipes (japanese killifish) PHUM005071-PA Pediculus humanus (human body louse) ENSPPYP00000008706 Pongo pygmaeus (orangutan) ENSPTRP00000047049 Pan troglodytes (chimpanzee) ENSRNOP00000001520 Rattus norvegicus (norway rat) Smp_157310 Schistosoma mansoni (trematode parasite) XP_780574.2 Strongylocentrotus purpuratus (purple sea urchin) 13161 Trichoplax adhaerens (metazoa) XP_969819.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013937 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041388 Takifugu rubripes (pufferfish Takifugu) 88026.m00145 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000026649 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35215 modMine - Data generated by the modENCODE project. • FBgn0041789 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50151 LH23026 ISCW009899 FBgn0230380 FBgn0225800 FBgn0205145 FBgn0193184 FBgn0171925 JGI_V11_306277 FBgn0076496 FBgn0158703 FBgn0139965 FBgn0120945 FBgn0113813 FBgn0092221 CPIJ003871 BGIBMGA002788 ACYPI003783 GB19612 AGAP008532 AAEL000339 PB24173 PHUM437870 GLEAN_10609
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG18061 (Pilot et al., 2006, Montana and Littleton, 2006) CG18576 (Mount, 2001.8.14, Hynes and Zhao, 2000, Yepiskoposyan et al., 2006) CG31794 (Brown, 2005.6.15, Stuart et al., 2007, Tanji et al., 2006, Goldman and Arbeitman, 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Cammarato et al., 2011) CT40481 (Wheeler and Hynes, 2001) CT42454 (Wheeler and Hynes, 2001) Dpax (Wheeler and Hynes, 2001, Chen et al., 2005) DpaxA (Chen et al., 2005) DPaxillin (Mende et al., 2003) DPxn (Mende et al., 2004) DPxn37 (Yagi et al., 2003, Yagi et al., 2001) Pax (Stuart et al., 2007, Tanji et al., 2006, Sandmann et al., 2006, Llense and Martín-Blanco, 2008, Junion et al., 2007, Leatherbarrow and Halfon, 2009, Hilger et al., 2009, Blard et al., 2007, Bataillé et al., 2010, Cunha et al., 2010) pax (Yi et al., 2007, Leatherbarrow and Halfon, 2009) PDLP (Yagi, 2001.2.27, Yagi et al., 2001)
Name Synonym	D-Paxillin (Llense and Martín-Blanco, 2008) paxillin (Petit et al., 2002, Yagi et al., 2003, Hynes and Zhao, 2000, Pilot et al., 2006, Bakal et al., 2007, Jani and Schock, 2007, Chen et al., 2005, James et al., 2007, Yagi et al., 2001, Zervas et al., 2011, He et al., 2010) Paxillin (Wheeler and Hynes, 2001, Hynes and Zhao, 2000, Bakal et al., 2007, Wu et al., 2008, Goldman and Arbeitman, 2007, Llense and Martín-Blanco, 2008, Tanentzapf and Brown, 2006, Alves-Silva et al., 2008, Blard et al., 2007, Yuan et al., 2010, Bataillé et al., 2010, Cammarato et al., 2011) Paxillin-derived LIM-only protein (Yuan et al., 2003) paxillin-derived LIM-only protein (Yagi, 2001.2.27)
Secondary FlyBase IDs
	FBgn0032776 FBgn0032777 FBgn0051794
References ( 69 )
Generate a list of	All references relating to this gene ( 69 )
List References by type	Research paper  ( 32 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 7 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 3 )
Recent research papers ( 6 )
	Zervas et al., 2011, J. Cell Sci. 124(8): 1316--1327 A central multifunctional role of integrin-linked kinase at muscle attachment sites. [FBrf0213331] Bataillé et al., 2010, Dev. Cell 19(2): 317--328 Downstream of Identity Genes: Muscle-Type-Specific Regulation of the Fusion Process. [FBrf0211535] Cunha et al., 2010, PLoS Genet. 6: e1001014 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. [FBrf0211225] He et al., 2010, Nat. Cell Biol. 12(12): 1133--1142 Tissue elongation requires oscillating contractions of a basal actomyosin network. [FBrf0212453] Lesch et al., 2010, Genetics 186(3): 943--957 A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes. [FBrf0212282] Yuan et al., 2010, J. Cell Sci. 123(6): 939--946 Analysis of integrin turnover in fly myotendinous junctions. [FBrf0213429] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...