v(2)k05816, FASNCG3524, FAS
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FASN2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\FASN2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
There are 3 Fatty acid synthase genes in the Dmel genome (FBrf0219401, FBrf0224329): CG3523 (aka FAS), CG3524 (aka mFAS) and CG17374. The CG3523 gene product is the major, ubiquitously expressed Fatty acid synthase of the three (and the most studied), while CG3524 and CG17374 have lower and more restricted expression (FBrf0219401, FBrf0224329; also see modENCODE RNAseq). The following systematic and informative symbols have therefore been adopted: CG3523 = 'FASN1', CG3524 = 'FASN2' and CG17374 = 'FASN3'. ('FASN', rather than 'FAS', has been used as a shared prefix as this more clearly distinguishes these 'Fatty acid synthase' genes from the unrelated 'faint sausage' gene (symbol 'fas') and 'Fasciclin' genes (symbols 'Fas1', 'Fas2' and 'Fas3'). Furthermore 'FASN' is the HGNC symbol for the human ortholog.)
Fatty acid synthase (FASN) is encoded by three distinct genes: CG3523, CG3524 and CG17374. Of these, CG3523 is the only FASN gene that is expressed in internal organs, has an essential function (outside of oenocytes), and whose expression affects total triacylglycerol levels in vivo.
This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (firstname.lastname@example.org).