FlyBase Gene Report: Dmel\frc

General Information

Symbol

Dmel\frc

Species

D. melanogaster

Name

fringe connection

Annotation Symbol

CG3874

Feature Type

protein_coding_gene

FlyBase ID

FBgn0042641

Gene Model Status

Stock Availability

14 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

l(3)02619, l(3)00073

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:17,428,936..17,433,190 [-]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:17428936..17433190

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (22 terms)

Molecular Function (9 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

enables antiporter activity

inferred from direct assay

(Muraoka et al., 2007)

NOT enables GDP-fucose transmembrane transporter activity

inferred from direct assay

(Goto et al., 2001, Selva et al., 2001)

NOT enables GDP-mannose transmembrane transporter activity

inferred from direct assay

(Goto et al., 2001, Selva et al., 2001)

enables UDP-galactose transmembrane transporter activity

inferred from direct assay

(Goto et al., 2001, Selva et al., 2001)

enables UDP-glucose transmembrane transporter activity

inferred from direct assay

(Goto et al., 2001, Selva et al., 2001)

enables UDP-glucuronic acid transmembrane transporter activity

inferred from direct assay

(Muraoka et al., 2007, Goto et al., 2001, Selva et al., 2001)

enables UDP-N-acetylglucosamine transmembrane transporter activity

inferred from direct assay

(Muraoka et al., 2007, Goto et al., 2001, Selva et al., 2001)

enables UDP-xylose transmembrane transporter activity

inferred from direct assay

(Selva et al., 2001)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables antiporter activity

inferred from biological aspect of ancestor with PANTHER:PTN002540544

(assigned by GO_Central )

(Gaudet et al., 2011)

enables UDP-glucuronic acid transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000123234

(assigned by GO_Central )

(Gaudet et al., 2011)

enables UDP-N-acetylgalactosamine transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000123234

(assigned by GO_Central )

(Gaudet et al., 2011)

enables UDP-N-acetylglucosamine transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000123234

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (11 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

involved_in compound eye morphogenesis

inferred from mutant phenotype

(Goto et al., 2001)

involved_in embryonic pattern specification

inferred from mutant phenotype

(Goto et al., 2001, Selva et al., 2001)

involved_in imaginal disc pattern formation

inferred from mutant phenotype

(Selva et al., 2001)

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Goto et al., 2001)

involved_in segment polarity determination

inferred from mutant phenotype

(Zhu et al., 2005)

involved_in sensory organ development

inferred from mutant phenotype

(Goto et al., 2001)

involved_in UDP-galactose transmembrane transport

inferred from direct assay

(Goto et al., 2001)

involved_in UDP-glucose transmembrane transport

inferred from direct assay

(Goto et al., 2001)

involved_in UDP-glucuronic acid transmembrane transport

inferred from direct assay

(Muraoka et al., 2007, Goto et al., 2001, Selva et al., 2001)

involved_in UDP-N-acetylglucosamine transmembrane transport

inferred from direct assay

(Muraoka et al., 2007, Goto et al., 2001, Selva et al., 2001)

involved_in UDP-xylose transmembrane transport

inferred from direct assay

(Selva et al., 2001)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in Golgi medial cisterna

inferred from direct assay

(Yamamoto-Hino et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in Golgi apparatus

inferred from biological aspect of ancestor with PANTHER:PTN002540544

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

SLC35 FAMILY OF NUCLEOTIDE SUGAR TRANSPORTERS

Protein Family (UniProt)

Belongs to the TPT transporter family. SLC35D subfamily. (Q95YI5)

Protein Signatures (InterPro)

Sugar phosphate transporter domain

Summaries

Gene Group (FlyBase)

SLC35 FAMILY OF NUCLEOTIDE SUGAR TRANSPORTERS -: Solute carrier family 35 (SLC35) members transport nucleotide sugars and adenosine 3'-phospho 5'-phosphosulfate from the cytosol to the endoplasmic reticulum and the Golgi apparatus. These sugars serve as substrates for the glycosylation and sulfation of proteins, lipids and proteoglycans. (Adapted from FBrf0221674, FBrf0193270 and PMID:23506892).

Protein Function (UniProtKB)

Involved in the import of UDP-sugars from the cytoplasm into the Golgi lumen.

(UniProt, Q95YI5)

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\frc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.54

Dicistronic transcript isoform(s) appear to be relatively rare based on RNA-Seq and/or EST data; may be stage- or tissue-specific.

Gene model reviewed during 5.46

gene_with_dicistronic_mRNA ; SO:0000722

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2008)

(FlyBase Genome Annotators, 2008)

protein_coding_gene

(FlyBase Genome Annotators, 2008)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0075228

1609

373

FBtr0299820

3871

373

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0074990

41.2

373

9.34

FBpp0289098

41.2

373

9.34

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

373 aa isoforms: frc-PA, frc-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Sugar phosphate transporter domain

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\frc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

frc_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

Comment: cyclical, peak ZT13-16

(Xu et al., 2011)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in Golgi medial cisterna

inferred from direct assay

(Yamamoto-Hino et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\frc in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\frc

View exonic expression by tissue for Dmel\frc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0042641

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0042641

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3874-RA;CG33052-RA;CG32174-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3874

Flygut - An atlas of the Drosophila adult midgut

FBgn0042641

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of frc

Transgenic constructs containing regulatory region of frc

Deletions and Duplications ( 4 )

Disrupted in

(Goto et al., 2001, Selva et al., 2001, Spradling et al., 1999, Szeged Stock Center, 1998-, Deak et al., 1997, BDGP Project Members, 1994-1999)

(Christensen et al., 2008.4.15)

(Christensen et al., 2008.4.15)

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PU

frc^{dsRNA.UAS.cYa}

lethal (with Df(3L)81k19)

frc^S070006

lethal (with frc⁰⁰⁰⁷³)

frc¹⁰⁰⁹⁸

lethal (with frc¹⁰⁰⁹⁸)

frc⁰⁰⁰⁷³

lethal (with frc^NP0297)

frc^R9

lethal (with frc^R9)

frc^NP0297

lethal | embryonic stage | recessive | rescuable maternal effect

lethal | larval stage | recessive

frc⁰²⁶¹⁹

lethal | pupal stage | recessive

lethal | recessive

lethal - all die before end of embryonic stage | germline clone | recessive

frc^R29

partially lethal - majority die

frc^RY34

partially lethal - majority die, with Scer\GAL4^pnr-MD237

frc^GD2691

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

frc^GD2691

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

frc^GD10475

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

cell polarity defective

frc^R29

cell polarity defective | somatic clone

frc^RY34

segment polarity phenotype | embryonic stage | germline clone | recessive

frc^R29

segment polarity phenotype | embryonic stage | recessive | rescuable maternal effect

some die during embryonic stage | recessive

frc^R29

some die during embryonic stage | rescuable maternal effect

frc⁰²⁶¹⁹

some die during pupal stage, with Scer\GAL4^pnr-MD237

frc^GD2691

some die during second instar larval stage

frc^RY34

visible | somatic clone

Phenotype manifest in

Allele

frc^R29

anterior postalar bristle

frc^NP0297

anterior scutellar bristle

frc^NP0297

frc⁰²⁶¹⁹

frc⁰²⁶¹⁹

embryonic/first instar larval cuticle

frc⁰⁰⁰⁷³

embryonic/first instar larval cuticle | germline clone

frc^R29

embryonic segment

frc⁰⁰⁰⁷³

frc^NP0297

eye photoreceptor cell

frc^R29

eye photoreceptor cell | somatic clone

frc^RY34

frc^R29

joint | somatic clone

frc^unspecified

frc^R29

leg | somatic clone

frc^unspecified

frc^NP0297

frc^unspecified

mesoderm | germline clone

frc^NP0297

posterior postalar bristle

frc^NP0297

presumptive embryonic/larval nervous system | germline clone

frc^R29

wing | somatic clone

frc^unspecified

wing margin | anterior | ectopic | somatic clone

frc^unspecified

wing margin | ectopic | somatic clone

frc^R9

wing margin bristle | ectopic | somatic clone

frc^unspecified

frc^NP0297

wing vein, with Scer\GAL4^A9

frc^{dsRNA.UAS.cYa}

wing vein, with Scer\GAL4^Bx-MS1096

frc^{dsRNA.UAS.cYa}

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

1

9 of 15

No

Yes

3 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

8 of 15

No

Yes

3 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

Rattus norvegicus (Norway rat) (5)

10 of 13

Yes

Yes

7 of 13

No

Yes

2 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (5)

11 of 12

Yes

Yes

3 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

Yes

Danio rerio (Zebrafish) (6)

8 of 15

Yes

Yes

8 of 15

Yes

Yes

5 of 15

No

Yes

Drer\LOC101884927

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

12 of 15

Yes

Yes

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (4)

8 of 9

Yes

Yes

3 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

9 of 15

Yes

Yes

6 of 15

No

Yes

1 of 15

No

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

7 of 12

Yes

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A0U )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00003976

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509NJ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY000514

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08396

Mayetiola destructor

Hessian fly

Mdes\Mdes001452

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014644

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014643

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014646

Anopheles darlingi

American malaria mosquito

Adar\ADAC003239

Anopheles darlingi

American malaria mosquito

Adar\ADAC003238

Anopheles gambiae

Malaria mosquito

Agam\AGAP005200

Anopheles gambiae

Malaria mosquito

Agam\AGAP005199

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019881

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006564

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006563

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0DD1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002053

Danaus plexippus

Monarch butterfly

Dple\DPOGS203392-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS204499-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008813

Heliconius melpomene

Postman butterfly

Hmel\HMEL007820

Apis florea

Little honeybee

Aflo\3857724548

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002ed1

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002ed2

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG037303

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG037304

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM493980

Rhodnius prolixus

Kissing bug

Rpro\RPRC014752

Rhodnius prolixus

Kissing bug

Rpro\RPRC007829

Cimex lectularius

Bed bug

Clec\CLEC013613

Cimex lectularius

Bed bug

Clec\CLEC000321

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009996

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008558

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001945

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13931

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08870

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CSE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR004892

Strigamia maritima

European centipede

Smar\SMAR001758

Ixodes scapularis

Black-legged tick

Isca\ISCW008296

Ixodes scapularis

Black-legged tick

Isca\ISCW009280

Ixodes scapularis

Black-legged tick

Isca\ISCW024909

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78812.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur03g01170

Tetranychus urticae

Two-spotted spider mite

Turt\tetur03g06250

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_61523

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_230099

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0KCU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc35d1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000001263

Ciona intestinalis

Vase tunicate

Cint\LOC100176985

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (3)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SLC35D1; solute carrier family 35 member D1

model of schneckenbecken dysplasia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC35D1; solute carrier family 35 member D1

13 of 15

SCHNECKENBECKEN DYSPLASIA; SHNKND

schneckenbecken dysplasia

SLC35D2; solute carrier family 35 member D2

9 of 15

TMEM241; transmembrane protein 241

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Selva et al., 2001)

suppressible

(Maixner et al., 1998)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65232

DroID - A comprehensive database of gene and protein interactions.

FBgn0042641

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39943

MIST (genetic) - An integrated Molecular Interaction Database

frc

MIST (protein-protein) - An integrated Molecular Interaction Database

frc

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-45

Cytogenetic map

Sequence location

3L:17,428,936..17,433,190 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

74B5-74C1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

74C1-74C2

(determined by in situ hybridisation)

(Spradling et al., 1999, Perrimon et al., 1996)

74B4-74B5

74C1--2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-40.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

10186

y¹ w¹¹¹⁸; P{lacW}frc^L6750/TM3, Ser¹

77098

y¹ sc^* v¹ sev²¹; P{TKO.GS00893}attP40

11572

P{PZ}frc⁰²⁶¹⁹ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

11484

P{PZ}frc⁰⁰⁰⁷³ Coq4⁰⁰⁰⁷³ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

103581

w^*; P{GawB}frc^NP0297 / TM3, Ser¹

114238

w^*; P{GawB}frc^NP7351 / CyO, P{UAS-lacZ.UW14}UW14

v107816

P{KK102002}VIE-260B

v5302

w¹¹¹⁸ P{GD2691}v5302

v47543

w¹¹¹⁸; P{GD2691}v47543

v21468

w¹¹¹⁸; P{GD10475}v21468

v21469

w¹¹¹⁸; P{GD10475}v21469

v47542

w¹¹¹⁸; P{GD2691}v47542/CyO

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (175)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH08077

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0042641

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0042641

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39943

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: frc CG3874

(Häcker, 2001.5.30)

Source for merge of: frc l(3)00073

(Goto et al., 2001, Selva et al., 2001)

Source for merge of: frc l(3)L6750 l(3)S070006 l(3)02619

(Richardson, 2005.2.11)

Source for merge of: frc anon-WO0172774.5 anon-WO0172774.7

(FlyBase, 1996-)

Additional comments

One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG32174 (FBgn0052174), CG3874 (FBgn0042641).

(FlyBase Genome Annotators, 2008)

Source for merge of frc anon-WO0172774.5 anon-WO0172774.7 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Mutations in frc affect wg-, hh- and FGF-dependent pathways and also fng/N-dependent pathways.

(Selva et al., 2001)

Mutant embryos that lack both maternal and zygotic frc activity exhibit defects in wg hh and FGF signalling pathways.

(Selva et al., 2000)

The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(w^hs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

(Perrimon et al., 1996)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39943

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q95YI5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

B7Z066

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0042641

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0042641

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

frc_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3874

Flygut - An atlas of the Drosophila adult midgut

FBgn0042641

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39943

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003250

InterPro - A database of protein families, domains and functional sites

Sugar phosphate transporter domain

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3874

modMine - A data warehouse for the modENCODE project

FBgn0042641

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

10186-frc[L6750]

BioGRID - A database of protein and genetic interactions.

65232

DPiM - Drosophila Protein interaction map

FBgn0042641

DroID - A comprehensive database of gene and protein interactions.

FBgn0042641

DRSC - Results frm RNAi screens

FBgn0042641

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0042641

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3874-RA;CG33052-RA;CG32174-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0042641

FlyMine - An integrated database for Drosophila genomics

FBgn0042641

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39943

MIST (genetic) - An integrated Molecular Interaction Database

frc

MIST (protein-protein) - An integrated Molecular Interaction Database

frc

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG3874

(Hosono et al., 2015, Yamamoto-Hino et al., 2015, Yamamoto-Hino et al., 2012, Keleman et al., 2009.8.5, Wang et al., 2004)

FRC

(Goda et al., 2006)

Frc

(Yamamoto-Hino et al., 2015, Yamamoto-Hino et al., 2012)

UDP-GlcNAc/UDP-GlcUA

(Kamiyama et al., 2003)

UST74C

(Goto, 2001.6.1)

anon-WO0172774.5

anon-WO0172774.7

dFRC

(Muraoka et al., 2007)

frc

(Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Iyer et al., 2016, Limmer et al., 2014, Sekine et al., 2013, Ambegaokar and Jackson, 2011, Xu et al., 2011, Dworkin et al., 2009, Bornemann et al., 2008, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, FlyBase Genome Annotators, 2008, Wang et al., 2008, Beltran et al., 2007, Wang et al., 2004)

l(3)00073

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(3)02619

(Hing et al., 1999, Spradling et al., 1999, Perrimon et al., 1996, BDGP Project Members, 1994-1999)

l(3)10098

(Maixner et al., 1998)

l(3)L6750

l(3)S070006

l(3)j2E3

ust74C

(Goto et al., 2001)

Name Synonyms

Fringe connection

(Muraoka et al., 2007)

Fringe-connection

(Yamamoto-Hino et al., 2012)

UDP-sugar transporter in 74C

(Goto et al., 2001)

frc

(FlyBase Genome Annotators, 2008)

fringe connection

(Ishikawa et al., 2010, Bornemann et al., 2008, Torroja et al., 2005, Selva et al., 2000)

Secondary FlyBase IDs

FBgn0010706
FBgn0010784
FBgn0011338
FBgn0024567
FBgn0028107
FBgn0036721
FBgn0046363
FBgn0046381

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (84)