FlyBase Gene Report: Dmel\frc

SLC35 FAMILY OF NUCLEOTIDE SUGAR TRANSPORTERS -: Solute carrier family 35 (SLC35) members transport nucleotide sugars and adenosine 3'-phospho 5'-phosphosulfate from the cytosol to the endoplasmic reticulum and the Golgi apparatus. These sugars serve as substrates for the glycosylation and sulfation of proteins, lipids and proteoglycans. (Adapted from FBrf0221674, FBrf0193270 and PMID:23506892).

Protein Function (UniProtKB)

Involved in the import of UDP-sugars from the cytoplasm into the Golgi lumen.

(UniProt, Q95YI5)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\frc or the JBrowse view of Dmel\frc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.54

Dicistronic transcript isoform(s) appear to be relatively rare based on RNA-Seq and/or EST data; may be stage- or tissue-specific.

Gene model reviewed during 5.46

gene_with_dicistronic_mRNA ; SO:0000722

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2008)

nuclear_gene

(FlyBase Genome Annotators, 2008)

protein_coding_gene

(FlyBase Genome Annotators, 2008)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

frc-RA

FBtr0075228

NM_079402

1609

373

frc-RB

FBtr0299820

NM_001144490

3871

373

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

frc-PA

FBpp0074990

41.2

373

9.34

NP_524126

AAF49343

frc-PB

FBpp0289098

41.2

373

9.34

NP_001137962

ACL83317

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

373 aa isoforms: frc-PA, frc-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Sugar phosphate transporter domain

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\frc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

frc_1

Linkouts

Gene Ontology (24 terms)

Molecular Function (11 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

antiporter activity

inferred from direct assay

(Muraoka et al., 2007)

NOT GDP-fucose transmembrane transporter activity

inferred from direct assay

(Goto et al., 2001, Selva et al., 2001)

NOT GDP-mannose transmembrane transporter activity

inferred from direct assay

(Goto et al., 2001, Selva et al., 2001)

UDP-galactose transmembrane transporter activity

inferred from direct assay

(Goto et al., 2001)

NOT UDP-galactose transmembrane transporter activity

inferred from direct assay

(Selva et al., 2001)

UDP-glucose transmembrane transporter activity

inferred from direct assay

(Goto et al., 2001)

NOT UDP-glucose transmembrane transporter activity

inferred from direct assay

(Selva et al., 2001)

UDP-glucuronic acid transmembrane transporter activity

inferred from direct assay

(Muraoka et al., 2007, Goto et al., 2001, Selva et al., 2001)

UDP-N-acetylglucosamine transmembrane transporter activity

inferred from direct assay

(Muraoka et al., 2007, Goto et al., 2001, Selva et al., 2001)

UDP-xylose transmembrane transporter activity

inferred from direct assay

(Selva et al., 2001)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

antiporter activity

inferred from biological aspect of ancestor with PANTHER:PTN002540544

(assigned by GO_Central )

(Gaudet et al., 2011)

pyrimidine nucleotide-sugar transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000123234

(assigned by GO_Central )

(Gaudet et al., 2011)

transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN002540544

(assigned by GO_Central )

(Gaudet et al., 2011)

UDP-glucuronic acid transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000123234

(assigned by GO_Central )

(Gaudet et al., 2011)

UDP-N-acetylgalactosamine transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000123234

(assigned by GO_Central )

(Gaudet et al., 2011)

UDP-N-acetylglucosamine transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000123234

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (11 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

compound eye morphogenesis