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Gene Dmel\HBS1

General Information
Symbol	Dmel\HBS1	Species	D. melanogaster
Name	HBS1	Annotation symbol	CG1898
Feature type	protein_coding_gene	FlyBase ID	FBgn0042712
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	62B7-62B7	Sequence location	3L:1,862,881..1,865,309 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene HBS1 is referred to in FlyBase by the symbol Dmel\HBS1 (CG1898, FBgn0042712). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation release factor activity. Based on sequence similarity, it is predicted to be involved in the biological process: translational termination. 3 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Domain of unknown function DUF1916; Protein synthesis factor, GTP-binding; Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal; Translation elongation factor EFTu/EF1A, C-terminal; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation/initiation factor/Ribosomal, beta-barrel. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624135_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of HBS1. Gene sequence location is 3L:1862881..1865309.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA08544 BKN27532
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62B7-62B7   Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\HBS1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) HBS1-RA FBtr0072866  NM_144472   2429   670
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein HBS1-PA   FBpp0072745   74.2   670   6.68     NP_652729   AAF47584
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein synthesis factor, GTP-binding (IPR000795) Translation elongation factor EFTu/EF1A, C-terminal (IPR004160) Translation elongation factor EFTu/EF1A, domain 2 (IPR004161) Translation elongation/initiation factor/Ribosomal, beta-barrel (IPR009000) Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal (IPR009001) Domain of unknown function DUF1916 (IPR015033)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695977   AA696862   AA820830   AA952043   AE014296 AAF47584   AI109830   AI388068   AI455532   AI457011   AI518185   AI520463   AI531957   AI542122   AW940714   AY060736 AAL28284   BF493927   BF496947   BF498446   BF503532   BI162682   BI162683   BI232912   BI352030   BI352615   BI485472   BI618996   BI640829   BT003766   BT120040   CL526122   CO270821   CO309214   EC083389   EC238331   EC252453
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95SK5 Q9W074
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0042712    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0042712 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0042712 expression level Developmental Stage   Expression Level embryo 00-02hr    4069 embryo 02-04hr    5697 embryo 04-06hr    4282 embryo 06-08hr    3704 embryo 08-10hr    3123 embryo 10-12hr    2780 embryo 12-14hr    1894 embryo 14-16hr    2261 embryo 16-18hr    1772 embryo 18-20hr    1493 embryo 20-22hr    1586 embryo 22-24hr    1488 larva L1    1574 larva L2    1360 larva L3 12hr old    1111 larva L3 puffstage 1-2    1142 larva L3 puffstage 3-6    1621 larva L3 puffstage 7-9    1829 white prepupae new    2008 white prepupae 12hr    3602 white prepupae 24hr    3716 pupae 2d postWPP    2750 pupae 3d postWPP    1638 pupae 4d postWPP    1842 adult male 01day    2366 adult male 05day    3185 adult male 30day    2992 adult female 01day    1945 adult female 05day    2147 adult female 30day    2291 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4069) embryo 02-04hr  (5697) embryo 04-06hr  (4282) embryo 06-08hr  (3704) embryo 08-10hr  (3123) embryo 10-12hr  (2780) embryo 12-14hr  (1894) embryo 14-16hr  (2261) embryo 16-18hr  (1772) embryo 18-20hr  (1493) embryo 20-22hr  (1586) embryo 22-24hr  (1488) larva L1  (1574) larva L2  (1360) larva L3 12hr old  (1111) larva L3 puffstage 1-2  (1142) larva L3 puffstage 3-6  (1621) larva L3 puffstage 7-9  (1829) white prepupae new  (2008) white prepupae 12hr  (3602) white prepupae 24hr  (3716) pupae 2d postWPP  (2750) pupae 3d postWPP  (1638) pupae 4d postWPP  (1842) adult male 01day  (2366) adult male 05day  (3185) adult male 30day  (2992) adult female 01day  (1945) adult female 05day  (2147) adult female 30day  (2291) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4069) embryo 02-04hr  (5697) embryo 04-06hr  (4282) embryo 06-08hr  (3704) embryo 08-10hr  (3123) embryo 10-12hr  (2780) embryo 12-14hr  (1894) embryo 14-16hr  (2261) embryo 16-18hr  (1772) embryo 18-20hr  1493 embryo 20-22hr  (1586) embryo 22-24hr  1488 larva L1  (1574) larva L2    1360 larva L3 12hr old    1111 larva L3 puffstage 1-2    1142 larva L3 puffstage 3-6  (1621) larva L3 puffstage 7-9  (1829) white prepupae new  (2008) white prepupae 12hr  (3602) white prepupae 24hr  (3716) pupae 2d postWPP  (2750) pupae 3d postWPP  (1638) pupae 4d postWPP  (1842) adult male 01day  (2366) adult male 05day  (3185) adult male 30day  (2992) adult female 01day  (1945) adult female 05day  (2147) adult female 30day  (2291) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4069 embryo 02-04hr    5697 embryo 04-06hr    4282 embryo 06-08hr    3704 embryo 08-10hr    3123 embryo 10-12hr    2780 embryo 12-14hr    1894 embryo 14-16hr    2261 embryo 16-18hr    1772 embryo 18-20hr    1493 embryo 20-22hr    1586 embryo 22-24hr    1488 larva L1    1574 larva L2    1360 larva L3 12hr old    1111 larva L3 puffstage 1-2    1142 larva L3 puffstage 3-6    1621 larva L3 puffstage 7-9    1829 white prepupae new    2008 white prepupae 12hr    3602 white prepupae 24hr    3716 pupae 2d postWPP    2750 pupae 3d postWPP    1638 pupae 4d postWPP    1842 adult male 01day    2366 adult male 05day    3185 adult male 30day    2992 adult female 01day    1945 adult female 05day    2147 adult female 30day    2291 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4069 embryo 02-04hr    5697 embryo 04-06hr    4282 embryo 06-08hr    3704 embryo 08-10hr    3123 embryo 10-12hr    2780 embryo 12-14hr    1894 embryo 14-16hr    2261 embryo 16-18hr    1772 embryo 18-20hr    1493 embryo 20-22hr    1586 embryo 22-24hr    1488 larva L1    1574 larva L2    1360 larva L3 12hr old    1111 larva L3 puffstage 1-2    1142 larva L3 puffstage 3-6    1621 larva L3 puffstage 7-9    1829 white prepupae new    2008 white prepupae 12hr    3602 white prepupae 24hr    3716 pupae 2d postWPP    2750 pupae 3d postWPP    1638 pupae 4d postWPP    1842 adult male 01day    2366 adult male 05day    3185 adult male 30day    2992 adult female 01day    1945 adult female 05day    2147 adult female 30day    2291 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0042712 expression level Developmental Stage   Expression Level embryo 00-02hr    4069 embryo 02-04hr    5697 embryo 04-06hr    4282 embryo 06-08hr    3704 embryo 08-10hr    3123 embryo 10-12hr    2780 embryo 12-14hr    1894 embryo 14-16hr    2261 embryo 16-18hr    1772 embryo 18-20hr    1493 embryo 20-22hr    1586 embryo 22-24hr    1488 larva L1    1574 larva L2    1360 larva L3 12hr old    1111 larva L3 puffstage 1-2    1142 larva L3 puffstage 3-6    1621 larva L3 puffstage 7-9    1829 white prepupae new    2008 white prepupae 12hr    3602 white prepupae 24hr    3716 pupae 2d postWPP    2750 pupae 3d postWPP    1638 pupae 4d postWPP    1842 adult male 01day    2366 adult male 05day    3185 adult male 30day    2992 adult female 01day    1945 adult female 05day    2147 adult female 30day    2291 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4069) embryo 02-04hr  (5697) embryo 04-06hr  (4282) embryo 06-08hr  (3704) embryo 08-10hr  (3123) embryo 10-12hr  (2780) embryo 12-14hr  (1894) embryo 14-16hr  (2261) embryo 16-18hr  (1772) embryo 18-20hr  (1493) embryo 20-22hr  (1586) embryo 22-24hr  (1488) larva L1  (1574) larva L2  (1360) larva L3 12hr old  (1111) larva L3 puffstage 1-2  (1142) larva L3 puffstage 3-6  (1621) larva L3 puffstage 7-9  (1829) white prepupae new  (2008) white prepupae 12hr  (3602) white prepupae 24hr  (3716) pupae 2d postWPP  (2750) pupae 3d postWPP  (1638) pupae 4d postWPP  (1842) adult male 01day  (2366) adult male 05day  (3185) adult male 30day  (2992) adult female 01day  (1945) adult female 05day  (2147) adult female 30day  (2291) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4069) embryo 02-04hr  (5697) embryo 04-06hr  (4282) embryo 06-08hr  (3704) embryo 08-10hr  (3123) embryo 10-12hr  (2780) embryo 12-14hr  1894 embryo 14-16hr  2261 embryo 16-18hr  1772 embryo 18-20hr  1493 embryo 20-22hr  1586 embryo 22-24hr  1488 larva L1  1574 larva L2    1360 larva L3 12hr old    1111 larva L3 puffstage 1-2    1142 larva L3 puffstage 3-6  1621 larva L3 puffstage 7-9  1829 white prepupae new  2008 white prepupae 12hr  (3602) white prepupae 24hr  (3716) pupae 2d postWPP  (2750) pupae 3d postWPP  1638 pupae 4d postWPP  1842 adult male 01day  2366 adult male 05day  (3185) adult male 30day  (2992) adult female 01day  1945 adult female 05day  2147 adult female 30day  2291 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4069 embryo 02-04hr    5697 embryo 04-06hr    4282 embryo 06-08hr    3704 embryo 08-10hr    3123 embryo 10-12hr    2780 embryo 12-14hr    1894 embryo 14-16hr    2261 embryo 16-18hr    1772 embryo 18-20hr    1493 embryo 20-22hr    1586 embryo 22-24hr    1488 larva L1    1574 larva L2    1360 larva L3 12hr old    1111 larva L3 puffstage 1-2    1142 larva L3 puffstage 3-6    1621 larva L3 puffstage 7-9    1829 white prepupae new    2008 white prepupae 12hr    3602 white prepupae 24hr    3716 pupae 2d postWPP    2750 pupae 3d postWPP    1638 pupae 4d postWPP    1842 adult male 01day    2366 adult male 05day    3185 adult male 30day    2992 adult female 01day    1945 adult female 05day    2147 adult female 30day    2291 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4069 embryo 02-04hr    5697 embryo 04-06hr    4282 embryo 06-08hr    3704 embryo 08-10hr    3123 embryo 10-12hr    2780 embryo 12-14hr    1894 embryo 14-16hr    2261 embryo 16-18hr    1772 embryo 18-20hr    1493 embryo 20-22hr    1586 embryo 22-24hr    1488 larva L1    1574 larva L2    1360 larva L3 12hr old    1111 larva L3 puffstage 1-2    1142 larva L3 puffstage 3-6    1621 larva L3 puffstage 7-9    1829 white prepupae new    2008 white prepupae 12hr    3602 white prepupae 24hr    3716 pupae 2d postWPP    2750 pupae 3d postWPP    1638 pupae 4d postWPP    1842 adult male 01day    2366 adult male 05day    3185 adult male 30day    2992 adult female 01day    1945 adult female 05day    2147 adult female 30day    2291 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0042712    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0042712 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0042712 expression level Tissue   Expression Level Larval Central Nervous System    177.275 Larval Midgut    156.8 Larval Hindgut    156.7 Larval Malpighian Tubules    178.1 Larval Fat Body    177.3 Larval Salivary Gland    264.3 Larval Trachea    208.2 Larval Carcass    198.25 Adult Head    135.3 Adult Eye    153.3 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    149.8 Adult Midgut    156.7 Adult Hindgut    128 Adult Malpighian Tubules    173.6 Adult Fat Body    140.3 Adult Salivary Gland    189.2 Adult Heart    114.55 Adult VirginFemale Spermatheca    130.6 Adult InseminatedFemale Spermatheca    141.2 Adult Ovary    210.3 Adult Testis    343.3 Adult Male Accessory Gland    163.2 Adult Carcass    118 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    177.275 Larval Midgut    156.8 Larval Hindgut    156.7 Larval Malpighian Tubules    178.1 Larval Fat Body    177.3 Larval Salivary Gland    264.3 Larval Trachea    208.2 Larval Carcass    198.25 Adult Head    135.3 Adult Eye    153.3 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    149.8 Adult Midgut    156.7 Adult Hindgut    128 Adult Malpighian Tubules    173.6 Adult Fat Body    140.3 Adult Salivary Gland    189.2 Adult Heart    114.55 Adult VirginFemale Spermatheca    130.6 Adult InseminatedFemale Spermatheca    141.2 Adult Ovary    210.3 Adult Testis    343.3 Adult Male Accessory Gland    163.2 Adult Carcass    118 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    177.275 Larval Midgut    156.8 Larval Hindgut    156.7 Larval Malpighian Tubules    178.1 Larval Fat Body    177.3 Larval Salivary Gland    264.3 Larval Trachea    208.2 Larval Carcass    198.25 Adult Head    135.3 Adult Eye    153.3 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    149.8 Adult Midgut    156.7 Adult Hindgut    128 Adult Malpighian Tubules    173.6 Adult Fat Body    140.3 Adult Salivary Gland    189.2 Adult Heart    114.55 Adult VirginFemale Spermatheca    130.6 Adult InseminatedFemale Spermatheca    141.2 Adult Ovary    210.3 Adult Testis    343.3 Adult Male Accessory Gland    163.2 Adult Carcass    118 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    177.275 Larval Midgut    156.8 Larval Hindgut    156.7 Larval Malpighian Tubules    178.1 Larval Fat Body    177.3 Larval Salivary Gland    264.3 Larval Trachea    208.2 Larval Carcass    198.25 Adult Head    135.3 Adult Eye    153.3 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    149.8 Adult Midgut    156.7 Adult Hindgut    128 Adult Malpighian Tubules    173.6 Adult Fat Body    140.3 Adult Salivary Gland    189.2 Adult Heart    114.55 Adult VirginFemale Spermatheca    130.6 Adult InseminatedFemale Spermatheca    141.2 Adult Ovary    210.3 Adult Testis    343.3 Adult Male Accessory Gland    163.2 Adult Carcass    118 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0042712 expression level Tissue   Expression Level Larval Central Nervous System    177.275 Larval Midgut    156.8 Larval Hindgut    156.7 Larval Malpighian Tubules    178.1 Larval Fat Body    177.3 Larval Salivary Gland    264.3 Larval Trachea    208.2 Larval Carcass    198.25 Adult Head    135.3 Adult Eye    153.3 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    149.8 Adult Midgut    156.7 Adult Hindgut    128 Adult Malpighian Tubules    173.6 Adult Fat Body    140.3 Adult Salivary Gland    189.2 Adult Heart    114.55 Adult VirginFemale Spermatheca    130.6 Adult InseminatedFemale Spermatheca    141.2 Adult Ovary    210.3 Adult Testis    343.3 Adult Male Accessory Gland    163.2 Adult Carcass    118 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    177.275 Larval Midgut    156.8 Larval Hindgut    156.7 Larval Malpighian Tubules    178.1 Larval Fat Body    177.3 Larval Salivary Gland    264.3 Larval Trachea    208.2 Larval Carcass    198.25 Adult Head    135.3 Adult Eye    153.3 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    149.8 Adult Midgut    156.7 Adult Hindgut    128 Adult Malpighian Tubules    173.6 Adult Fat Body    140.3 Adult Salivary Gland    189.2 Adult Heart    114.55 Adult VirginFemale Spermatheca    130.6 Adult InseminatedFemale Spermatheca    141.2 Adult Ovary    210.3 Adult Testis    343.3 Adult Male Accessory Gland    163.2 Adult Carcass    118 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    177.275 Larval Midgut    156.8 Larval Hindgut    156.7 Larval Malpighian Tubules    178.1 Larval Fat Body    177.3 Larval Salivary Gland    264.3 Larval Trachea    208.2 Larval Carcass    198.25 Adult Head    135.3 Adult Eye    153.3 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    149.8 Adult Midgut    156.7 Adult Hindgut    128 Adult Malpighian Tubules    173.6 Adult Fat Body    140.3 Adult Salivary Gland    189.2 Adult Heart    114.55 Adult VirginFemale Spermatheca    130.6 Adult InseminatedFemale Spermatheca    141.2 Adult Ovary    210.3 Adult Testis    343.3 Adult Male Accessory Gland    163.2 Adult Carcass    118 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    177.275 Larval Midgut    156.8 Larval Hindgut    156.7 Larval Malpighian Tubules    178.1 Larval Fat Body    177.3 Larval Salivary Gland    264.3 Larval Trachea    208.2 Larval Carcass    198.25 Adult Head    135.3 Adult Eye    153.3 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    149.8 Adult Midgut    156.7 Adult Hindgut    128 Adult Malpighian Tubules    173.6 Adult Fat Body    140.3 Adult Salivary Gland    189.2 Adult Heart    114.55 Adult VirginFemale Spermatheca    130.6 Adult InseminatedFemale Spermatheca    141.2 Adult Ovary    210.3 Adult Testis    343.3 Adult Male Accessory Gland    163.2 Adult Carcass    118 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    135.3   NA  Eye    153.3   NA  Brain    129.5   177.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    154.8   NA  Crop    149.8   156.8  Midgut    156.7   156.7  Hindgut    128   178.1  Malpighian Tubules    173.6   177.3  Fat Body    140.3   264.3  Salivary Gland    189.2   NA  Heart    114.55   208.2  Trachea    NA   NA  VirginFemale Spermatheca    130.6   NA  InseminatedFemale Spermatheca    141.2   NA  Ovary    210.3   NA  Testis    343.3   NA  Male Accessory Gland    163.2   198.25  Carcass    118 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0042712 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1898-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for HBS1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 HBS1GD9671 viable HBS1EY09557 Sterility Allele fertile HBS1EY09557 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 HBS1GD9671 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 HBS1GD9671 trichogen cell, with Scer\GAL4pnr-MD237 HBS1GD9671
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of HBS1 Class Mutagen Stocks Known lesion HBS1EY09557 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of HBS1 Class Mutagen Stocks Known lesion HBS1GD9671 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes HBS1KK107532 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6088 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9671} NA P{KK107532} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}HBS1EY09557 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from electronic annotation with InterPro:IPR000795 (FlyBase Curators et al., 2004-) GTP binding inferred from electronic annotation with InterPro:IPR000795, InterPro:IPR004160, InterPro:IPR004161 (FlyBase Curators et al., 2004-) translation release factor activity inferred from sequence or structural similarity with Saccharomyces SUP35 (FlyBase, 1992-)
Biological Process
CV term Evidence References
translational termination inferred from sequence or structural similarity with Saccharomyces SUP35 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytosol inferred from sequence or structural similarity with Saccharomyces SUP35 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions HBS1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0042712 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117365
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24953 Dere\GG14552 Dgri\GH15038 Dmoj\GI16690 Dper\GL24819 Dpse\GA23522 Dsec\GM14160 Dsim\GD13431 Dvir\GJ12942 Dwil\GK10605 Dyak\GE20906
Curated drosophilid orthologs	Dpse\GA15117
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000825-PA Aedes aegypti (mosquito) AGAP002603-PA Anopheles gambiae (mosquito) XP_623664.2 Apis mellifera (honey bee) XP_001951307.1 Acyrthosiphon pisum (pea aphid) At5g10630.1 Arabidopsis thaliana (wall cress) 9269 Batrachochytrium dendrobatidis (chytrid fungus) 123547 Branchiostoma floridae (lancelet) XP_001892663.1 Brugia malayi (roundworm nematode) BGIBMGA003395-PA Bombyx mori (silk worm) ENSBTAP00000026869 Bos taurus (bovine) CN30308 Caenorhabditis brenneri (small nematode) CBP35196 Caenorhabditis briggsae (nematode) CE39388 Caenorhabditis elegans (worm) ENSCAFP00000000327 Canis familiaris (dog) ENSCINP00000011616 Ciona intestinalis (sea squirt) JA01573 Caenorhabditis japonica (nematode) cn02101 Cryptococcus neoformans (yeast-like fungus) CPIJ013330 Culex pipens (mosquito) ENSCPOP00000006327 Cavia porcellus (guinea pig) 99082 Chlamidomonas reinhardtii (green alga) RP19071 Caenorhabditis remanei (nematode) ENSCSAVP00000003889 Ciona savignyi (sedentary tunicate) 178027 Capitella spl (polychaete worm) DDB0201566 Dictyostelium discoideum (amoeba) 303602 Daphnia pulex (daphnia) ENSDARP00000053400 Danio rerio (zebra fish) ENSECAP00000004522 Equus caballus (horse) NP_417231.1 Escherichia coli K12 (bacteria) ENSGACP00000014608 Gymnopilus aculeatus (mushroom) ENSGALP00000022592 Gallus gallus (chicken) 101631 Hypsipyla robusta (cedar shoot borer) ENSP00000356811 Homo sapiens (human) ISCW011989-PA Ixodes scapularis (deer tick) 142523 Lottia gigantea (owl limpet) ENSMODP00000021834 Monodelphis domestica (gray opossum) ENSMMUP00000006386 Macaca mulatta (rhesus monkey) ENSMUSP00000020153 Mus musculus (house mouse) 86416 Nematostella vectensis (starlet anemone) XP_001606343.1 Nasonia vitripennis (wasp) ENSOANP00000004281 Ornithorynchus anatinus (platypus) ENSORLP00000020730 Oryzias latipes (japanese killifish) LOC_Os01g02720.1 Oryza sativa (asian rice) LOC_Os04g50870.1 Oryza sativa (asian rice) 8406 Ostreococcus tauri (green alga) PHUM003532-PA Pediculus humanus (human body louse) ENSPPYP00000019067 Pongo pygmaeus (orangutan) 40092 Phytophthora ramorum (sudden oak death pathogen) 121742 Phytophthora sojae (root rot pathogen) 271547 Populus trichocarpa (black cottonwood) ENSPTRP00000031800 Pan troglodytes (chimpanzee) ENSRNOP00000019734 Rattus norvegicus (norway rat) 4888869 Sorghum bicolor (sorghum) Smp_130790.2 Schistosoma mansoni (trematode parasite) 64067 Trichoplax adhaerens (metazoa) XP_968959.1 Tribolium castaneum (red flour beetle) ENSTNIP00000001091 Tetraodon nigroviridis (green spotted pufferfish) 337 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041225 Takifugu rubripes (pufferfish Takifugu) 99.m00155 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000008062 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13337 LH24579 ISCW011989 FBgn0238195 FBgn0212620 FBgn0200176 FBgn0185144 FBgn0169086 JGI_V11_303602 FBgn0244923 FBgn0162407 FBgn0139438 FBgn0122513 FBgn0106810 FBgn0101945 CPIJ013330 BGIBMGA003395 ACYPI008124 GB10530 AGAP002603 AAEL000825 PB20842 PHUM040510 GLEAN_03854
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	17580 y1 w67c23; P{EPgy2}HBS1EY09557
VDRC	v104327 P{KK107532}VIE-260B v33419 w1118; P{GD9671}v33419 v33420 w1118; P{GD9671}v33420/TM3
Genomic Clones ( 1 )
	BACR10D15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH18819 RE29053
Other clones	FI04779
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02314 AT04731 AT10963 AT12855 GH09207 GM04855 GM08576 GM17290 GM20069 LD24738 LD29071 LD37216 LD37628 LD40637 RE68801 RH49953 SD03273 SD08220 SD23836
Other clones	10809 157999 214571.24 EK100408 EK260659 RE01933
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0042712 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117365
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: HBS1 CG1898 (FlyBase, 1996-)
Additional comments	Source for merge of HBS1 CG1898 was a shared cDNA (GH18819) (date:011030). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_144472 RefSeq (Proteins) • NP_652729 DDBJ / EMBL / GenBank • AA952043 AAF47584 AAL28284 AI388068 AI455532 AW940714 AY060736 BI232912 CL526122 Entrez Gene - A searchable database of RefSeq genes. • 117365 UniProtKB/TrEMBL • Q9W074 Q95SK5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein synthesis factor, GTP-binding (IPR000795) Translation elongation factor EFTu/EF1A, C-terminal (IPR004160) Translation elongation factor EFTu/EF1A, domain 2 (IPR004161) Translation elongation/initiation factor/Ribosomal, beta-barrel (IPR009000) Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal (IPR009001) Domain of unknown function DUF1916 (IPR015033)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0042712 DRSC - Results from RNAi screens. • FBgn0042712 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0042712 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1898-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0042712 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117365 InParanoid A subset of ortholog calls from InParanoid. • AAEL000825-PA Aedes aegypti (mosquito) AGAP002603-PA Anopheles gambiae (mosquito) XP_623664.2 Apis mellifera (honey bee) XP_001951307.1 Acyrthosiphon pisum (pea aphid) At5g10630.1 Arabidopsis thaliana (wall cress) 9269 Batrachochytrium dendrobatidis (chytrid fungus) 123547 Branchiostoma floridae (lancelet) XP_001892663.1 Brugia malayi (roundworm nematode) BGIBMGA003395-PA Bombyx mori (silk worm) ENSBTAP00000026869 Bos taurus (bovine) CN30308 Caenorhabditis brenneri (small nematode) CBP35196 Caenorhabditis briggsae (nematode) CE39388 Caenorhabditis elegans (worm) ENSCAFP00000000327 Canis familiaris (dog) ENSCINP00000011616 Ciona intestinalis (sea squirt) JA01573 Caenorhabditis japonica (nematode) cn02101 Cryptococcus neoformans (yeast-like fungus) CPIJ013330 Culex pipens (mosquito) ENSCPOP00000006327 Cavia porcellus (guinea pig) 99082 Chlamidomonas reinhardtii (green alga) RP19071 Caenorhabditis remanei (nematode) ENSCSAVP00000003889 Ciona savignyi (sedentary tunicate) 178027 Capitella spl (polychaete worm) DDB0201566 Dictyostelium discoideum (amoeba) 303602 Daphnia pulex (daphnia) ENSDARP00000053400 Danio rerio (zebra fish) ENSECAP00000004522 Equus caballus (horse) NP_417231.1 Escherichia coli K12 (bacteria) ENSGACP00000014608 Gymnopilus aculeatus (mushroom) ENSGALP00000022592 Gallus gallus (chicken) 101631 Hypsipyla robusta (cedar shoot borer) ENSP00000356811 Homo sapiens (human) ISCW011989-PA Ixodes scapularis (deer tick) 142523 Lottia gigantea (owl limpet) ENSMODP00000021834 Monodelphis domestica (gray opossum) ENSMMUP00000006386 Macaca mulatta (rhesus monkey) ENSMUSP00000020153 Mus musculus (house mouse) 86416 Nematostella vectensis (starlet anemone) XP_001606343.1 Nasonia vitripennis (wasp) ENSOANP00000004281 Ornithorynchus anatinus (platypus) ENSORLP00000020730 Oryzias latipes (japanese killifish) LOC_Os01g02720.1 Oryza sativa (asian rice) LOC_Os04g50870.1 Oryza sativa (asian rice) 8406 Ostreococcus tauri (green alga) PHUM003532-PA Pediculus humanus (human body louse) ENSPPYP00000019067 Pongo pygmaeus (orangutan) 40092 Phytophthora ramorum (sudden oak death pathogen) 121742 Phytophthora sojae (root rot pathogen) 271547 Populus trichocarpa (black cottonwood) ENSPTRP00000031800 Pan troglodytes (chimpanzee) ENSRNOP00000019734 Rattus norvegicus (norway rat) 4888869 Sorghum bicolor (sorghum) Smp_130790.2 Schistosoma mansoni (trematode parasite) 64067 Trichoplax adhaerens (metazoa) XP_968959.1 Tribolium castaneum (red flour beetle) ENSTNIP00000001091 Tetraodon nigroviridis (green spotted pufferfish) 337 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041225 Takifugu rubripes (pufferfish Takifugu) 99.m00155 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000008062 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117365 modMine - Data generated by the modENCODE project. • FBgn0042712 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13337 LH24579 ISCW011989 FBgn0238195 FBgn0212620 FBgn0200176 FBgn0185144 FBgn0169086 JGI_V11_303602 FBgn0244923 FBgn0162407 FBgn0139438 FBgn0122513 FBgn0106810 FBgn0101945 CPIJ013330 BGIBMGA003395 ACYPI008124 GB10530 AGAP002603 AAEL000825 PB20842 PHUM040510 GLEAN_03854
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG1898 (Labourier et al., 2002, Keleman et al., 2009.8.5) HBS1 (Kind et al., 2008, Gelbart et al., 2009, Cronin et al., 2009) hbs1 (Kind et al., 2008)
Name Synonym	HBS1
Secondary FlyBase IDs
	FBgn0035284
References ( 18 )
Research paper	Cronin et al., 2009, Science 325(5938): 340--343 Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. [FBrf0208489] Gelbart et al., 2009, Nat. Struct. Mol. Biol. 16(8): 825--832 Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation. [FBrf0208599] Kind et al., 2008, Cell 133(5): 813--828 Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. [FBrf0204874] Labourier et al., 2002, Genes Dev. 16(1): 72--84 The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing. [FBrf0141540] Inagaki and Ford Doolittle, 2000, Molec. Biol. Evol. 17(6): 882--889 Evolution of the eukaryotic translation termination system: origins of release factors. [FBrf0131050]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Lasko, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126679]