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Gene Dmel\AP-2σ

General Information
Symbol	Dmel\AP-2σ	Species	D. melanogaster
Name	Adaptor Protein complex 2, σ subunit	Annotation symbol	CG6056
Feature type	protein_coding_gene	FlyBase ID	FBgn0043012
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	AP-2sigma, σ2, aps2
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	93D2-93D2	Sequence location	3R:17,094,931..17,095,797 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Adaptor Protein complex 2, σ subunit is referred to in FlyBase by the symbol Dmel\AP-2σ (CG6056, FBgn0043012). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein transporter activity. There is experimental evidence that it is involved in the biological process: endocytosis; neurogenesis. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: AP complex, mu/sigma subunit; AP-2 complex subunit sigma; Adaptor protein complex, sigma subunit; Clathrin adaptor complex, small chain; Longin-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult midgut, adult hindgut, adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627202_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of AP-2sigma. Gene sequence location is 3R:17094931..17095797.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 93D2-93D2   Limits computationally determined from genome sequence between P{PZ}Atpα01164 and P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101
Experimentally Determined Cytological Location
Cytogenetic map Notes References 93D-93E   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\AP-2σ for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) AP-2σ-RA FBtr0084103  NM_142704   751   142
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein AP-2σ-PA   FBpp0083502   17.0   142   6.11     NP_650961   AAF55874
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Clathrin adaptor complex, small chain (IPR000804) Longin-like domain (IPR011012) Adaptor protein complex, sigma subunit (IPR016635) AP-2 complex subunit sigma (IPR027156) AP complex, mu/sigma subunit (IPR022775)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55874   AF228055 AAG43052   AK342337   AY231968   BG634154   BH740773   BH740774   BI228596   BI238725   BI368781   BI617268   BI624830   BP547244   BP548102   BP555737   BP555738   BT010252 AAQ23570   CK135455   CO178508   CO270032   CO274898   CO316164   CO321456   CO345251   DQ440086   EC057125   EC071456   EC084195   EC086758   EC211790   EC218605   EC248673   EV575808   EV580679   EV593706   GH771159   GH781766   GH821152   GH825906   GH844189   GH851056   GH864012   GH864615   GH891848   GH908057   GH922457   GH922740
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VDC3 Q9GQM7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   garland cell primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval garland cell   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
AP-2 adaptor complex inferred from mutant phenotype (Windler and Bilder, 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult midgut, adult hindgut, adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    850.6 Larval Midgut    354.3 Larval Hindgut    555.9 Larval Malpighian Tubules    1065.2 Larval Fat Body    786.6 Larval Salivary Gland    856.2 Larval Trachea    618.25 Larval Carcass    530.5 Adult Head    563.2 Adult Eye    570.925 Adult Brain    983 Adult Thoracic-Abdominal Ganglion    1019.3 Adult Crop    398.5 Adult Midgut    358.9 Adult Hindgut    454.6 Adult Malpighian Tubules    570 Adult Fat Body    336.3 Adult Salivary Gland    468.8 Adult Heart    920.1 Adult VirginFemale Spermatheca    284.4 Adult InseminatedFemale Spermatheca    259.9 Adult Ovary    534.7 Adult Testis    161.6 Adult Male Accessory Gland    243.3 Adult Carcass    349.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (850.6) Larval Midgut    354.3 Larval Hindgut  (555.9) Larval Malpighian Tubules  (1065.2) Larval Fat Body  (786.6) Larval Salivary Gland  (856.2) Larval Trachea  (618.25) Larval Carcass  530.5 Adult Head  (563.2) Adult Eye  (570.925) Adult Brain  (983) Adult Thoracic-Abdominal Ganglion  (1019.3) Adult Crop    398.5 Adult Midgut    358.9 Adult Hindgut    454.6 Adult Malpighian Tubules  (570) Adult Fat Body    336.3 Adult Salivary Gland    468.8 Adult Heart  (920.1) Adult VirginFemale Spermatheca    284.4 Adult InseminatedFemale Spermatheca    259.9 Adult Ovary  534.7 Adult Testis    161.6 Adult Male Accessory Gland    243.3 Adult Carcass    349.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    850.6 Larval Midgut    354.3 Larval Hindgut    555.9 Larval Malpighian Tubules  1065.2 Larval Fat Body    786.6 Larval Salivary Gland    856.2 Larval Trachea    618.25 Larval Carcass    530.5 Adult Head    563.2 Adult Eye    570.925 Adult Brain    983 Adult Thoracic-Abdominal Ganglion  1019.3 Adult Crop    398.5 Adult Midgut    358.9 Adult Hindgut    454.6 Adult Malpighian Tubules    570 Adult Fat Body    336.3 Adult Salivary Gland    468.8 Adult Heart    920.1 Adult VirginFemale Spermatheca    284.4 Adult InseminatedFemale Spermatheca    259.9 Adult Ovary    534.7 Adult Testis    161.6 Adult Male Accessory Gland    243.3 Adult Carcass    349.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    850.6 Larval Midgut    354.3 Larval Hindgut    555.9 Larval Malpighian Tubules    1065.2 Larval Fat Body    786.6 Larval Salivary Gland    856.2 Larval Trachea    618.25 Larval Carcass    530.5 Adult Head    563.2 Adult Eye    570.925 Adult Brain    983 Adult Thoracic-Abdominal Ganglion    1019.3 Adult Crop    398.5 Adult Midgut    358.9 Adult Hindgut    454.6 Adult Malpighian Tubules    570 Adult Fat Body    336.3 Adult Salivary Gland    468.8 Adult Heart    920.1 Adult VirginFemale Spermatheca    284.4 Adult InseminatedFemale Spermatheca    259.9 Adult Ovary    534.7 Adult Testis    161.6 Adult Male Accessory Gland    243.3 Adult Carcass    349.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    850.6 Larval Midgut    354.3 Larval Hindgut    555.9 Larval Malpighian Tubules    1065.2 Larval Fat Body    786.6 Larval Salivary Gland    856.2 Larval Trachea    618.25 Larval Carcass    530.5 Adult Head    563.2 Adult Eye    570.925 Adult Brain    983 Adult Thoracic-Abdominal Ganglion    1019.3 Adult Crop    398.5 Adult Midgut    358.9 Adult Hindgut    454.6 Adult Malpighian Tubules    570 Adult Fat Body    336.3 Adult Salivary Gland    468.8 Adult Heart    920.1 Adult VirginFemale Spermatheca    284.4 Adult InseminatedFemale Spermatheca    259.9 Adult Ovary    534.7 Adult Testis    161.6 Adult Male Accessory Gland    243.3 Adult Carcass    349.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (850.6) Larval Midgut    354.3 Larval Hindgut  555.9 Larval Malpighian Tubules  (1065.2) Larval Fat Body  786.6 Larval Salivary Gland  (856.2) Larval Trachea  618.25 Larval Carcass  530.5 Adult Head  563.2 Adult Eye  570.925 Adult Brain  (983) Adult Thoracic-Abdominal Ganglion  (1019.3) Adult Crop    398.5 Adult Midgut    358.9 Adult Hindgut    454.6 Adult Malpighian Tubules  570 Adult Fat Body    336.3 Adult Salivary Gland    468.8 Adult Heart  (920.1) Adult VirginFemale Spermatheca    284.4 Adult InseminatedFemale Spermatheca    259.9 Adult Ovary  534.7 Adult Testis    161.6 Adult Male Accessory Gland    243.3 Adult Carcass    349.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    850.6 Larval Midgut    354.3 Larval Hindgut    555.9 Larval Malpighian Tubules  1065.2 Larval Fat Body    786.6 Larval Salivary Gland    856.2 Larval Trachea    618.25 Larval Carcass    530.5 Adult Head    563.2 Adult Eye    570.925 Adult Brain    983 Adult Thoracic-Abdominal Ganglion  1019.3 Adult Crop    398.5 Adult Midgut    358.9 Adult Hindgut    454.6 Adult Malpighian Tubules    570 Adult Fat Body    336.3 Adult Salivary Gland    468.8 Adult Heart    920.1 Adult VirginFemale Spermatheca    284.4 Adult InseminatedFemale Spermatheca    259.9 Adult Ovary    534.7 Adult Testis    161.6 Adult Male Accessory Gland    243.3 Adult Carcass    349.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    850.6 Larval Midgut    354.3 Larval Hindgut    555.9 Larval Malpighian Tubules    1065.2 Larval Fat Body    786.6 Larval Salivary Gland    856.2 Larval Trachea    618.25 Larval Carcass    530.5 Adult Head    563.2 Adult Eye    570.925 Adult Brain    983 Adult Thoracic-Abdominal Ganglion    1019.3 Adult Crop    398.5 Adult Midgut    358.9 Adult Hindgut    454.6 Adult Malpighian Tubules    570 Adult Fat Body    336.3 Adult Salivary Gland    468.8 Adult Heart    920.1 Adult VirginFemale Spermatheca    284.4 Adult InseminatedFemale Spermatheca    259.9 Adult Ovary    534.7 Adult Testis    161.6 Adult Male Accessory Gland    243.3 Adult Carcass    349.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    563.2   NA  Eye    570.925   NA  Brain    983   850.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1019.3   NA  Crop    398.5   354.3  Midgut    358.9   555.9  Hindgut    454.6   1065.2  Malpighian Tubules    570   786.6  Fat Body    336.3   856.2  Salivary Gland    468.8   NA  Heart    920.1   618.25  Trachea    NA   NA  VirginFemale Spermatheca    284.4   NA  InseminatedFemale Spermatheca    259.9   NA  Ovary    534.7   NA  Testis    161.6   NA  Male Accessory Gland    243.3   530.5  Carcass    349.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    45 central nervous system, pupae P8    65 head, virgin 1-day female    39 head, virgin 4-day female    27 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    24 head, mated 20-day female    16 head, mated 1-day male    50 head, mated 4-day male    44 head, mated 20-day male    38 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    49 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    17 digestive system, 4-day adult    17 digestive system, 20-day adult    18 fat body, larvae L3 wandering    15 fat body, white prepupae    43 fat body, pupae P8    53 carcass, larvae L3 wandering    37 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    38 ovary, mated 4-day female    35 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (29) central nervous system, larvae L3  (45) central nervous system, pupae P8  (65) head, virgin 1-day female  (39) head, virgin 4-day female  (27) head, virgin 20-day female    21 head, mated 1-day female  (29) head, mated 4-day female    24 head, mated 20-day female    16 head, mated 1-day male  (50) head, mated 4-day male  (44) head, mated 20-day male  (38) salivary gland, larvae L3 wandering  (32) salivary gland, white prepupae  (49) digestive system, larvae L3 wandering  (49) digestive system, 1-day adult    17 digestive system, 4-day adult    17 digestive system, 20-day adult    18 fat body, larvae L3 wandering    15 fat body, white prepupae  (43) fat body, pupae P8  (53) carcass, larvae L3 wandering  (37) carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female  (38) ovary, mated 4-day female  (35) testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    45 central nervous system, pupae P8    65 head, virgin 1-day female    39 head, virgin 4-day female    27 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    24 head, mated 20-day female    16 head, mated 1-day male    50 head, mated 4-day male    44 head, mated 20-day male    38 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    49 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    17 digestive system, 4-day adult    17 digestive system, 20-day adult    18 fat body, larvae L3 wandering    15 fat body, white prepupae    43 fat body, pupae P8    53 carcass, larvae L3 wandering    37 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    38 ovary, mated 4-day female    35 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    45 central nervous system, pupae P8    65 head, virgin 1-day female    39 head, virgin 4-day female    27 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    24 head, mated 20-day female    16 head, mated 1-day male    50 head, mated 4-day male    44 head, mated 20-day male    38 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    49 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    17 digestive system, 4-day adult    17 digestive system, 20-day adult    18 fat body, larvae L3 wandering    15 fat body, white prepupae    43 fat body, pupae P8    53 carcass, larvae L3 wandering    37 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    38 ovary, mated 4-day female    35 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    45 central nervous system, pupae P8    65 head, virgin 1-day female    39 head, virgin 4-day female    27 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    24 head, mated 20-day female    16 head, mated 1-day male    50 head, mated 4-day male    44 head, mated 20-day male    38 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    49 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    17 digestive system, 4-day adult    17 digestive system, 20-day adult    18 fat body, larvae L3 wandering    15 fat body, white prepupae    43 fat body, pupae P8    53 carcass, larvae L3 wandering    37 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    38 ovary, mated 4-day female    35 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  29 central nervous system, larvae L3  (45) central nervous system, pupae P8  (65) head, virgin 1-day female  (39) head, virgin 4-day female  27 head, virgin 20-day female    21 head, mated 1-day female  29 head, mated 4-day female    24 head, mated 20-day female    16 head, mated 1-day male  (50) head, mated 4-day male  (44) head, mated 20-day male  (38) salivary gland, larvae L3 wandering  32 salivary gland, white prepupae  (49) digestive system, larvae L3 wandering  (49) digestive system, 1-day adult    17 digestive system, 4-day adult    17 digestive system, 20-day adult    18 fat body, larvae L3 wandering    15 fat body, white prepupae  (43) fat body, pupae P8  (53) carcass, larvae L3 wandering  (37) carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female  (38) ovary, mated 4-day female  (35) testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    45 central nervous system, pupae P8    65 head, virgin 1-day female    39 head, virgin 4-day female    27 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    24 head, mated 20-day female    16 head, mated 1-day male    50 head, mated 4-day male    44 head, mated 20-day male    38 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    49 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    17 digestive system, 4-day adult    17 digestive system, 20-day adult    18 fat body, larvae L3 wandering    15 fat body, white prepupae    43 fat body, pupae P8    53 carcass, larvae L3 wandering    37 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    38 ovary, mated 4-day female    35 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    45 central nervous system, pupae P8    65 head, virgin 1-day female    39 head, virgin 4-day female    27 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    24 head, mated 20-day female    16 head, mated 1-day male    50 head, mated 4-day male    44 head, mated 20-day male    38 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    49 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    17 digestive system, 4-day adult    17 digestive system, 20-day adult    18 fat body, larvae L3 wandering    15 fat body, white prepupae    43 fat body, pupae P8    53 carcass, larvae L3 wandering    37 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    38 ovary, mated 4-day female    35 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    47 embryo 04-06hr    92 embryo 06-08hr    99 embryo 08-10hr    99 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    65 embryo 16-18hr    75 embryo 18-20hr    67 embryo 20-22hr    48 embryo 22-24hr    53 larva L1    57 larva L2    49 larva L3 12hr old    42 larva L3 puffstage 1-2    49 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    88 white prepupae new    96 white prepupae 12hr    69 white prepupae 24hr    66 pupae 2d postWPP    73 pupae 3d postWPP    64 pupae 4d postWPP    48 adult male 01day    37 adult male 05day    34 adult male 30day    32 adult female 01day    54 adult female 05day    64 adult female 30day    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (69) embryo 02-04hr  (47) embryo 04-06hr  (92) embryo 06-08hr  (99) embryo 08-10hr  (99) embryo 10-12hr  (91) embryo 12-14hr  (80) embryo 14-16hr  (65) embryo 16-18hr  (75) embryo 18-20hr  (67) embryo 20-22hr  (48) embryo 22-24hr  (53) larva L1  (57) larva L2  (49) larva L3 12hr old  (42) larva L3 puffstage 1-2  (49) larva L3 puffstage 3-6  (63) larva L3 puffstage 7-9  (88) white prepupae new  (96) white prepupae 12hr  (69) white prepupae 24hr  (66) pupae 2d postWPP  (73) pupae 3d postWPP  (64) pupae 4d postWPP  (48) adult male 01day  (37) adult male 05day  (34) adult male 30day  (32) adult female 01day  (54) adult female 05day  (64) adult female 30day  (65) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    47 embryo 04-06hr    92 embryo 06-08hr    99 embryo 08-10hr    99 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    65 embryo 16-18hr    75 embryo 18-20hr    67 embryo 20-22hr    48 embryo 22-24hr    53 larva L1    57 larva L2    49 larva L3 12hr old    42 larva L3 puffstage 1-2    49 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    88 white prepupae new    96 white prepupae 12hr    69 white prepupae 24hr    66 pupae 2d postWPP    73 pupae 3d postWPP    64 pupae 4d postWPP    48 adult male 01day    37 adult male 05day    34 adult male 30day    32 adult female 01day    54 adult female 05day    64 adult female 30day    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    47 embryo 04-06hr    92 embryo 06-08hr    99 embryo 08-10hr    99 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    65 embryo 16-18hr    75 embryo 18-20hr    67 embryo 20-22hr    48 embryo 22-24hr    53 larva L1    57 larva L2    49 larva L3 12hr old    42 larva L3 puffstage 1-2    49 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    88 white prepupae new    96 white prepupae 12hr    69 white prepupae 24hr    66 pupae 2d postWPP    73 pupae 3d postWPP    64 pupae 4d postWPP    48 adult male 01day    37 adult male 05day    34 adult male 30day    32 adult female 01day    54 adult female 05day    64 adult female 30day    65 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    47 embryo 04-06hr    92 embryo 06-08hr    99 embryo 08-10hr    99 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    65 embryo 16-18hr    75 embryo 18-20hr    67 embryo 20-22hr    48 embryo 22-24hr    53 larva L1    57 larva L2    49 larva L3 12hr old    42 larva L3 puffstage 1-2    49 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    88 white prepupae new    96 white prepupae 12hr    69 white prepupae 24hr    66 pupae 2d postWPP    73 pupae 3d postWPP    64 pupae 4d postWPP    48 adult male 01day    37 adult male 05day    34 adult male 30day    32 adult female 01day    54 adult female 05day    64 adult female 30day    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (69) embryo 02-04hr  (47) embryo 04-06hr  (92) embryo 06-08hr  (99) embryo 08-10hr  (99) embryo 10-12hr  (91) embryo 12-14hr  (80) embryo 14-16hr  (65) embryo 16-18hr  (75) embryo 18-20hr  (67) embryo 20-22hr  (48) embryo 22-24hr  (53) larva L1  (57) larva L2  (49) larva L3 12hr old  (42) larva L3 puffstage 1-2  (49) larva L3 puffstage 3-6  (63) larva L3 puffstage 7-9  (88) white prepupae new  (96) white prepupae 12hr  (69) white prepupae 24hr  (66) pupae 2d postWPP  (73) pupae 3d postWPP  (64) pupae 4d postWPP  (48) adult male 01day  (37) adult male 05day  (34) adult male 30day  32 adult female 01day  (54) adult female 05day  (64) adult female 30day  (65) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    47 embryo 04-06hr    92 embryo 06-08hr    99 embryo 08-10hr    99 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    65 embryo 16-18hr    75 embryo 18-20hr    67 embryo 20-22hr    48 embryo 22-24hr    53 larva L1    57 larva L2    49 larva L3 12hr old    42 larva L3 puffstage 1-2    49 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    88 white prepupae new    96 white prepupae 12hr    69 white prepupae 24hr    66 pupae 2d postWPP    73 pupae 3d postWPP    64 pupae 4d postWPP    48 adult male 01day    37 adult male 05day    34 adult male 30day    32 adult female 01day    54 adult female 05day    64 adult female 30day    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    47 embryo 04-06hr    92 embryo 06-08hr    99 embryo 08-10hr    99 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    65 embryo 16-18hr    75 embryo 18-20hr    67 embryo 20-22hr    48 embryo 22-24hr    53 larva L1    57 larva L2    49 larva L3 12hr old    42 larva L3 puffstage 1-2    49 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    88 white prepupae new    96 white prepupae 12hr    69 white prepupae 24hr    66 pupae 2d postWPP    73 pupae 3d postWPP    64 pupae 4d postWPP    48 adult male 01day    37 adult male 05day    34 adult male 30day    32 adult female 01day    54 adult female 05day    64 adult female 30day    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    64 embryonic 1182-4H    70 embryonic GM2    76 embryonic Kc167    57 embryonic S1    65 embryonic S3    59 leg disc CME L1    83 wing disc CME-W2    108 wing disc ML-DmD8    56 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    58 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    112 tumorous blood cells mbn2    34 ovary fGS/OSS    43 ovary OSC    66 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (42) Schneider line 2 Sg4  (64) embryonic 1182-4H  (70) embryonic GM2  (76) embryonic Kc167  (57) embryonic S1  (65) embryonic S3  (59) leg disc CME L1  (83) wing disc CME-W2  (108) wing disc ML-DmD8  (56) wing disc ML-DmD9  (68) wing disc ML-DmD16-c3  (51) wing disc ML-DmD21  (58) wing disc ML-DmD32  (66) haltere disc ML-DmD17-c3  (62) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (76) mixed discs ML-DmD4-c1  (54) CNS ML-DmBG1-c1  (56) CNS ML-DmBG2-c2  (112) tumorous blood cells mbn2  (34) ovary fGS/OSS  (43) ovary OSC  (66) ovary OSS  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    64 embryonic 1182-4H    70 embryonic GM2    76 embryonic Kc167    57 embryonic S1    65 embryonic S3    59 leg disc CME L1    83 wing disc CME-W2  (108) wing disc ML-DmD8    56 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    58 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2  (112) tumorous blood cells mbn2    34 ovary fGS/OSS    43 ovary OSC    66 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    64 embryonic 1182-4H    70 embryonic GM2    76 embryonic Kc167    57 embryonic S1    65 embryonic S3    59 leg disc CME L1    83 wing disc CME-W2    108 wing disc ML-DmD8    56 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    58 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    112 tumorous blood cells mbn2    34 ovary fGS/OSS    43 ovary OSC    66 ovary OSS    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    64 embryonic 1182-4H    70 embryonic GM2    76 embryonic Kc167    57 embryonic S1    65 embryonic S3    59 leg disc CME L1    83 wing disc CME-W2    108 wing disc ML-DmD8    56 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    58 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    112 tumorous blood cells mbn2    34 ovary fGS/OSS    43 ovary OSC    66 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (42) Schneider line 2 Sg4  (64) embryonic 1182-4H  (70) embryonic GM2  (76) embryonic Kc167  (57) embryonic S1  (65) embryonic S3  (59) leg disc CME L1  (83) wing disc CME-W2  (108) wing disc ML-DmD8  (56) wing disc ML-DmD9  (68) wing disc ML-DmD16-c3  (51) wing disc ML-DmD21  (58) wing disc ML-DmD32  (66) haltere disc ML-DmD17-c3  (62) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (76) mixed discs ML-DmD4-c1  (54) CNS ML-DmBG1-c1  (56) CNS ML-DmBG2-c2  (112) tumorous blood cells mbn2  (34) ovary fGS/OSS  (43) ovary OSC  (66) ovary OSS  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    64 embryonic 1182-4H    70 embryonic GM2    76 embryonic Kc167    57 embryonic S1    65 embryonic S3    59 leg disc CME L1    83 wing disc CME-W2  108 wing disc ML-DmD8    56 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    58 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2  112 tumorous blood cells mbn2    34 ovary fGS/OSS    43 ovary OSC    66 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    64 embryonic 1182-4H    70 embryonic GM2    76 embryonic Kc167    57 embryonic S1    65 embryonic S3    59 leg disc CME L1    83 wing disc CME-W2    108 wing disc ML-DmD8    56 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    58 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    112 tumorous blood cells mbn2    34 ovary fGS/OSS    43 ovary OSC    66 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    25 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    56 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    25 heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3  (30) Cadmium 50 mM 12 hrs, larvae L3  (56) Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult  (27) Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3  (35) Ethanol 10% 3 hrs, larvae L3  26 Caffeine 1.5 mg/ml 4 hrs, larvae L3  26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  (34) Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    25 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    56 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    25 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    56 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    25 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    56 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    25 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3  30 Cadmium 50 mM 12 hrs, larvae L3  (56) Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult  27 Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3  (35) Ethanol 10% 3 hrs, larvae L3  26 Caffeine 1.5 mg/ml 4 hrs, larvae L3  26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  (34) Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    25 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    56 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    25 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    56 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • RE35245 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043012 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6056-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for AP-2σ Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal AP-2σGD10560 lethal | pupal stage, with Scer\GAL4pnr-MD237 AP-2σGD10560 Other Phenotypes Allele neuroanatomy defective | larval stage AP-2σGD10560 neuroanatomy defective | recessive | somatic clone AP-2σKG02457 Phenotype manifest in Allele embryonic/larval brain | somatic clone AP-2σKG02457 embryonic/larval neuroblast | larval stage AP-2σGD10560 embryonic/larval neuroblast | somatic clone | supernumerary AP-2σKG02457
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of AP-2σ Class Mutagen Stocks Known lesion AP-2σKG02457 loss of function allele P-element activity 1 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of AP-2σ Class Mutagen Stocks Known lesion AP-2σGD10560 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AP-2σJF02631 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AP-2σKK102525 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes AP-2σNIG.6056R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}AP-2σKG02457 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
protein transporter activity inferred from mutant phenotype (Windler and Bilder, 2010)
Biological Process
CV term Evidence References
endocytosis inferred from mutant phenotype (Windler and Bilder, 2010) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
AP-2 adaptor complex inferred from mutant phenotype (Windler and Bilder, 2010)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
intracellular protein transport inferred from electronic annotation with InterPro:IPR000804 (FlyBase Curators et al., 2004-) neurotransmitter secretion non-traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle coating traceable author statement (Stimson and Ramaswami, 1999) vesicle coating traceable author statement (Stimson and Ramaswami, 1999)
Cellular Component
CV term Evidence References
coated vesicle traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle traceable author statement (Stimson and Ramaswami, 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
AP-2σ - 14-3-3ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - AP-1-2β experimental knowledge based (Guruharsha et al., 2011) AP-2σ - AP-2α anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) AP-2σ - AP-2μ experimental knowledge based (Guruharsha et al., 2011) AP-2σ - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG12301 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG13472 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG15784 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG32344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG3735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG42557 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) AP-2σ - CG4617 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG5726 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG6227 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG7845 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG8043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG9253 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - CG9911 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - Hexim experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) AP-2σ - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - LanB1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - Larp7 experimental knowledge based (Guruharsha et al., 2011) AP-2σ - Mbs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - Nak experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) AP-2σ - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - Ntf-2 experimental knowledge based (Guruharsha et al., 2011) AP-2σ - Pp1-87B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - Reps experimental knowledge based (Guruharsha et al., 2011) AP-2σ - Rlip experimental knowledge based (Guruharsha et al., 2011) AP-2σ - RpS27A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - Sec23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - Srp72 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - Syx6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - abs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - eIF-4E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - tyf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - vri anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-2σ - wcd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions AP-2σ allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67495 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0043012 DroID - A comprehensive database of gene and protein interactions. • FBgn0043012 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42525
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6D7ZS9 Dipteran inclusive ortholog search EOG6868NV Insect inclusive ortholog search EOG6QJQJR Arthropod inclusive ortholog search EOG6NGF45 Metazoa inclusive ortholog search EOG6ZWJ66
Orthologs in Drosophila Species (EOG6D7ZS9)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\AP-2σ     Drosophila simulans   Dsim\GD19995 Y   Drosophila sechellia   Dsec\GM15088 Y   Drosophila erecta   Dere\GG14749 Y   Drosophila yakuba   Dyak\AP-2σ Y   Drosophila ananassae   Dana\GF17262 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19327 Y   Drosophila persimilis   Dper\GL27163 Y   Drosophila willistoni   Dwil\GK12771 Y   Drosophila virilis   Dvir\GJ14442 Y   Drosophila mojavensis   Dmoj\GI10836 Y   Drosophila grimshawi   Dgri\GH18926 Y
Orthologs in non-Drosophila Dipterans (EOG6868NV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014375   Anopheles gambiae Malaria mosquito  Agam\AGAP001703   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009504
Orthologs in non-Dipteran Insects (EOG6QJQJR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002994   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12889   Atta cephalotes Leafcutter ant  Acep\ACEP21949   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16692   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18862   Linepithema humile Argentine ant  Lhum\LH16963   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12879   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001489   Bombyx mori Silkmoth  Bmor\BGIBMGA000800   Pediculus humanus Human body louse  Phum\PHUM515120   Tribolium castaneum Red flour beetle  Tcas\TC009991
Orthologs in non-Insect Arthropods (EOG6NGF45)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_303876   Ixodes scapularis Deer tick  Isca\ISCW011294
Orthologs in non-Arthropod Metazoa (EOG6ZWJ66)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\aps-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012559gn   Danio rerio Zebrafish  Drer\zgc:65827   Xenopus tropicalis Western clawed frog  Xtro\ap2s1   Gallus gallus Domestic chicken  Ggal\ENSGALG00000000439   Mus musculus House mouse  Mmus\Ap2s1   Rattus norvegicus Norway rat  Rnor\Ap2s1   Homo sapiens Human  Hsap\AP2S1
Human Orthologs (1)
Gene OMIM HGNC Hsap\AP2S1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19995 Drosophila sechellia Dsec\GM15088 Drosophila erecta Dere\GG14749 Drosophila yakuba Dyak\AP-2σ Drosophila ananassae Dana\GF17262 Drosophila pseudoobscura pseudoobscura Dpse\GA19327 Drosophila persimilis Dper\GL27163 Drosophila willistoni Dwil\GK12771 Drosophila virilis Dvir\GJ14442 Drosophila mojavensis Dmoj\GI10836 Drosophila grimshawi Dgri\GH18926
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	27322 y1 v1; P{TRiP.JF02631}attP2 13478 y1; ry506 P{SUPor-P}AP-2σKG02457/TM3, Sb1 Ser1
VDRC	v34148 w1118 P{GD10560}v34148
Genomic Clones ( 2 )
	BACR06L13 BACR10M16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE35245
Other clones	DPiM_RE35245 yak-em_AP
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT30258 RE26182 RE54817 RH64534
Other clones	19697 60949 74531 109081 CK01.8D.C11 CK01.71D.H1 CK01.142C.F6 Dmel_dig_000727_0631_0305 Dmel_dig_007133_0585_2833 Dmel_neb_014024_0677_2199 EK056922 EK097202 EK115855 EK185723 EK263828 EP21703 FGH114H10 FGH124A07 FGM236H04 RH47542 RP003031708 RP003039471 RP003145753 RP003174533 RP003187968 RP003234668 RP003304424 RP003306544 RP003330299 RP003334615 RP003590426 RP003597234
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0043012 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42525
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: AP-2σ CG6056 (FlyBase, 1996-)
Additional comments	Source for merge of AP-2σ CG6056 was sequence comparison (date:010102). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142704 RefSeq (Proteins) • NP_650961 DDBJ / EMBL / GenBank • AAF55874 AAG43052 AAQ23570 AF228055 BH740773 BH740774 BI238725 BT010252 Entrez Gene - A searchable database of RefSeq genes. • 42525 UniProtKB/TrEMBL • Q9GQM7 Q9VDC3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Clathrin adaptor complex, small chain (IPR000804) Longin-like domain (IPR011012) Adaptor protein complex, sigma subunit (IPR016635) AP-2 complex subunit sigma (IPR027156) AP complex, mu/sigma subunit (IPR022775) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE35245
Linkouts
	BioGRID - A database of protein and genetic interactions • 67495 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0043012 DroID - A comprehensive database of gene and protein interactions. • FBgn0043012 DRSC - Results from RNAi screens. • FBgn0043012 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043012 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6056-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0043012 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42525 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42525 modMine - Data generated by the modENCODE project. • FBgn0043012
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	AP2 (Comet et al., 2006) AP-2sigma (Giot et al., 2003, Perkins et al., 2009.8.10, Neumüller et al., 2011, Japanese National Institute of Genetics, 2012.5.21) AP-2 sigma (Yano et al., 2012) AP-2σ (Peng et al., 2009, Song and Lu, 2012, Windler and Bilder, 2010, Bonifacino et al., 2012.12.21) aps2 (Neumann et al., 2010, Neumann et al., 2010) cg6056 (Boehm and Bonifacino, 2002) CG6056 (Boehm, 2001, Mount, 2001.8.14, Keleman et al., 2009.8.5, Yano et al., 2012) σ2 (Boehm and Bonifacino, 2001, Mullins et al., 2000, )
Name Synonym	Adaptor Protein complex 2, σ subunit (Bonifacino et al., 2012.12.21, ) AP-2σ
Secondary FlyBase IDs
	FBgn0038875 FBgn0043468
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 8 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 4 )
	Song and Lu, 2012, J. Biol. Chem. 287(21): 17716--17728 Interaction of Notch Signaling Modulator Numb with α-Adaptin Regulates Endocytosis of Notch Pathway Components and Cell Fate Determination of Neural Stem Cells. [FBrf0218342] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Robinson and Moberg, 2011, Cell Cycle 10(23): 4110--4118 Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. [FBrf0217243] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...