FlyBase Gene Report: Dmel\MESK2

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MESK2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

MESK2_1

Linkouts

Gene Ontology (2 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000867215

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000867215

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

wing pouch | restricted

(Molnar et al., 2012)

wing hinge primordium | restricted

(Molnar et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\MESK2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\MESK2

View exonic expression by tissue for Dmel\MESK2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0043070

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0043070

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG15669-RD;CT35853;CG15669-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG15669

Flygut - An atlas of the Drosophila adult midgut

FBgn0043070

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\MESK2

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 27 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of MESK2

Transgenic constructs containing regulatory region of MESK2

Deletions and Duplications ( 4 )

Disrupted in

Df(2L)Prl

(BDGP Project Members, 1994-1999)

Df(2R)E3578

(BDGP Project Members, 1994-1999)

Df(2R)Exel6076

(Ryder, 2004.4.26)

Df(2R)Pu-D17

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2R)Exel6076)

MESK2^{MI01548-TG4.2}

lethal | recessive

lethal - all die before end of pupal stage | recessive

MESK2^k05623

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

MESK2^GD9083

viable

MESK2^EY04505

viable, with Scer\GAL4^- :

MESK2^EP2347

viable, with Scer\GAL4^Mef2.PR

MESK2^GD9083

viable, with Scer\GAL4^pnr-MD237

MESK2^GD9083

viable, with Scer\GAL4^tin.CΔ4

MESK2^GD9083

Sterility

Allele

fertile

MESK2^EY04505

Other Phenotypes

Allele

some die during pupal stage | recessive

MESK2^k05623

visible | recessive

MESK2^k05623

Phenotype manifest in

Allele

imaginal disc

wing vein

MESK2^k05623

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\NDRG3

13 of 15

Yes

Hsap\NDRG1

11 of 15

Yes

Hsap\NDRG2

9 of 15

Yes

Hsap\NDRG4

9 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ndrg3

13 of 15

Yes

Mmus\Ndrg1

12 of 15

Yes

Mmus\Ndrg2

10 of 15

Yes

Mmus\Ndrg4

9 of 15

Yes

Rattus norvegicus (Norway rat) (6)

Rnor\Ndrg1

11 of 13

Yes

Rnor\Ndrg2

10 of 13

Yes

Rnor\Ndrg4

10 of 13

Yes

Rnor\Ndrg3

6 of 13

Yes

Rnor\LOC679863

1 of 13

Yes

Rnor\LOC108348290

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\ndrg4

11 of 12

Yes

Xtro\ndrg1

9 of 12

Yes

Xtro\ndrg2

9 of 12

Yes

Xtro\ndrg3

9 of 12

Yes

Danio rerio (Zebrafish) (6)

Drer\ndrg1a

12 of 15

Yes

Drer\ndrg3a

12 of 15

Yes

Drer\ndrg3b

12 of 15

Yes

Drer\ndrg1b

11 of 15

Yes

Drer\ndrg2

11 of 15

Yes

Drer\ndrg4

9 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\Y48G10A.3

12 of 15

Yes

Cele\ZK1073.1

2 of 15

Cele\ZK1225.2

1 of 15

Arabidopsis thaliana (thale-cress) (3)

Atha\NDL3

9 of 9

Yes

Atha\NDL1

8 of 9

Yes

Atha\NDL2

8 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905YK )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\MESK2

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA25012

Drosophila persimilis

Dper\GL16980

Drosophila willistoni

Dwil\GK20902

Drosophila virilis

Dvir\GJ20053

Drosophila mojavensis

Dmoj\GI19078

Drosophila mojavensis

Dmoj\GI17264

Drosophila grimshawi

Dgri\GH21835

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915056L )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17027294

Glossina morsitans

Tsetse fly

Gmor\GMOY005786

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13974

Mayetiola destructor

Hessian fly

Mdes\Mdes008736

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004307

Anopheles darlingi

American malaria mosquito

Adar\ADAC005926

Anopheles gambiae

Malaria mosquito

Agam\AGAP008821

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009201

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03TM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA000597

Bombyx mori

Silkmoth

Bmor\BGIBMGA004945

Danaus plexippus

Monarch butterfly

Dple\DPOGS207158-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202289-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL013029

Heliconius melpomene

Postman butterfly

Hmel\HMEL013050

Apis florea

Little honeybee

Aflo\2844867764

Apis mellifera

Western honey bee

Amel\GB54474

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21023

Bombus terrestris

Buff-tailed bumblebee

Bter\15211327

Linepithema humile

Argentine ant

Lhum\LH21822

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0029d6

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG017555

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05124

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05125

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00380

Tribolium castaneum

Red flour beetle

Tcas\TC003984

Pediculus humanus

Human body louse

Phum\PHUM475680

Rhodnius prolixus

Kissing bug

Rpro\RPRC000145

Cimex lectularius

Bed bug

Clec\CLEC001238

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006423

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11106

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03QV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW010241

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68963.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56754.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur37g00020

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g03050

Tetranychus urticae

Two-spotted spider mite

Turt\tetur43g00230

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_53060

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05QM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ndrg1L

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

5 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

NDRG1; N-myc downstream regulated 1

model of Charcot-Marie-Tooth disease type 4D

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NDRG3; NDRG family member 3

13 of 15

605273

NDRG1; N-myc downstream regulated 1

11 of 15

605262

CHARCOT-MARIE-TOOTH DISEASE, TYPE 4D; CMT4D

Charcot-Marie-Tooth disease type 4D

NDRG2; NDRG family member 2

9 of 15

605272

NDRG4; NDRG family member 4

9 of 15

614463

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

MESK2 - Rtnl1

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Ida et al., 2009)

suppressible

(Huang and Rubin, 2000)

peb

suppressible

MESK2

(Wilk et al., 2004)

Ras85D

enhanceable

MESK2

(Schnorr et al., 2001, Huang and Rubin, 2000)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63080

DroID - A comprehensive database of gene and protein interactions.

FBgn0043070

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37451

MIST (genetic) - An integrated Molecular Interaction Database

MESK2

MIST (protein-protein) - An integrated Molecular Interaction Database

MESK2

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-95

Cytogenetic map

57E8-57E9

Sequence location

2R:21,502,097..21,517,241 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

57E8-57E9

Limits computationally determined from genome sequence between P{PZ}tmx¹&P{EP}MESK2^EP2347 and P{PZ}Egfr⁰⁵³⁵¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

57E6-57E7

(Huang, 1999.10.18, Huang, 1999.10.18)

57E6-57E7

(determined by in situ hybridisation)

(Huang and Rubin, 2000, Spradling et al., 1999)

57E-57E

(determined by in situ hybridisation)

(Roch et al., 1998)

57E5-57E7

57E5--8 57E6--10 57E6--7

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-95

(FlyBase, 2016)

2-101.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (18)

Bloomington

17241

w¹¹¹⁸; P{EP}MESK2^EP2347

43431

w^*; P{GSV1}MESK2^EP-634.2

29380

y¹ v¹; P{TRiP.JF03312}attP2

34209

y¹ w^*; Mi{MIC}MESK2^MI01548

11056

cn¹ P{PZ}MESK2⁰¹⁴⁶⁷/CyO; ry⁵⁰⁶

19841

y¹ w^67c23; P{EPgy2}MESK2^EY04505

37980

y¹ w^*; Mi{MIC}MESK2^MI04765/SM6a

Harvard

e01591

PBac{RB}MESK2^e01591

Kyoto

123876

w¹¹¹⁸; P{RS3}MESK2^CB-5906-3

103637

w^*; P{GawB}MESK2^NP0524 / CyO

VDRC

v105492

P{KK107898}VIE-260B

v19536

w¹¹¹⁸; P{GD9083}v19536

More stocks available...

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (154)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0043070

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0043070

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37451

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: MESK2 CG15668 CG15669

(FlyBase, 1996-)

Source for database merge of

Source for merge of: MESK2 l(2)01467

(Schnorr et al., 2001)

Source for merge of: MESK2 BcDNA:LD27504

(FlyBase, 1996-)

Source for merge of: MESK2 BcDNA:RH10174

(FlyBase, 1996-)

Source for merge of: MESK2 BcDNA:GH12032

(FlyBase, 1996-)

Additional comments

Source for identity of MESK2 CG15668 CG15669 was sequence comparison ( date:001108 ).

(FlyBase, 1996-)

Source for merge of MESK2 BcDNA:LD27504 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Source for merge of MESK2 BcDNA:RH10174 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Source for merge of MESK2 BcDNA:GH12032 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Other Comments

Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

(Roch et al., 1998)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 106 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37451

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0043070

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0043070

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

MESK2_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG15669

Flygut - An atlas of the Drosophila adult midgut

FBgn0043070

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37451

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003984

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG15669

modMine - A data warehouse for the modENCODE project

FBgn0043070

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

BioGRID - A database of protein and genetic interactions.

63080

DPiM - Drosophila Protein interaction map

FBgn0043070

DroID - A comprehensive database of gene and protein interactions.

FBgn0043070

DRSC - Results frm RNAi screens

FBgn0043070

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0043070

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG15669-RD;CT35853;CG15669-RB

FlyMine - An integrated database for Drosophila genomics

FBgn0043070

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37451

MIST (genetic) - An integrated Molecular Interaction Database

MESK2

MIST (protein-protein) - An integrated Molecular Interaction Database

MESK2

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

BcDNA:GH12032

BcDNA:LD27504

BcDNA:RH10174

CG15668

CG15669

(Yamaguchi and Takashima, 2018, Kumar et al., 2016, Hosono et al., 2015, Ida et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Molnar et al., 2006, Orian et al., 2003)

MESK2

(Yildirim et al., 2019, Al-Ramahi et al., 2018, Lee et al., 2018, Yamaguchi and Takashima, 2018, Bussmann and Storkebaum, 2017, Hu et al., 2017.6.13, Gene Disruption Project members, 2016-, Kavi et al., 2015, Ashwal-Fluss et al., 2014, Bischof and FlyORF project members, 2014.6.20, Das et al., 2013, de Celis et al., 2013.9.11, Senthilan et al., 2012, Ida et al., 2009, Larsen et al., 2006, Jordan et al., 2005)

Mesk2

(Molnar et al., 2006)

l(2)01467

(Spradling et al., 1999, Roch et al., 1998, BDGP Project Members, 1994-1999)

mesk2

(Larsen et al., 2006)

Name Synonyms

Misexpression suppressor of KSR 2

(Huang, 1999.10.18, Huang, 1999.10.18)

Secondary FlyBase IDs

FBgn0010491
FBgn0034632
FBgn0034633
FBgn0046775
FBgn0047042
FBgn0064967

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (66)

Report Sections

Open Close