FlyBase Gene Report: Dmel\bchs

General Information

Symbol

Dmel\bchs

Species

D. melanogaster

Name

blue cheese

Annotation Symbol

CG14001

Feature Type

protein_coding_gene

FlyBase ID

FBgn0043362

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Snapshot

blue cheese (bchs) is a neuronally expressed gene that encodes a member of the BEACH (Beige and Chediak-Higashi)-domain superfamily, whose members are involved in vesicle trafficking. It antagonizes the activity of the product of Rab11. It serves as a scaffold for autophagy proteins, and contributes to ref(2)P-mediated aggrephagy. It contributes to nervous system development, lysosome transport and sphingolipid metabolism. [Date last reviewed: 2018-11-08]

Other Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

Beach1, EP2299, Beached, DBEACH1

Key Links

Genomic Location

Cytogenetic map

26A1-26A1

Sequence location

2L:5,907,169..5,922,776 [+]

Recombination map

2-18

RefSeq locus

NT_033779 REGION:5907169..5922776

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables metal ion binding

inferred from electronic annotation with InterPro:IPR000306

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (10 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

involved_in brain development

inferred from mutant phenotype

(assigned by BHF-UCL )

(Kriston-Vizi et al., 2011)

involved_in chaeta development

inferred from genetic interaction with FLYBASE:Rab11; FB:FBgn0015790

(Khodosh et al., 2006)

involved_in compound eye development

inferred from mutant phenotype

(Khodosh et al., 2006)

involved_in fasciculation of motor neuron axon

inferred from mutant phenotype

(Lim and Kraut, 2009)

involved_in lysosome localization

inferred from mutant phenotype

(Lim and Kraut, 2009)

involved_in microtubule bundle formation

inferred from mutant phenotype

(Lim and Kraut, 2009)

involved_in neuron development

inferred from mutant phenotype

(Simonsen et al., 2007)

involved_in positive regulation of organ growth

inferred from mutant phenotype

(assigned by BHF-UCL )

(Kriston-Vizi et al., 2011)

involved_in regulation of protein ubiquitination

inferred from mutant phenotype

(Simonsen et al., 2007)

involved_in regulation of synapse organization

inferred from genetic interaction with FLYBASE:Rab11; FB:FBgn0015790

(Khodosh et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Finley et al., 2003)

located_in lysosome

inferred from direct assay

(Lim and Kraut, 2009)

located_in neuromuscular junction

inferred from direct assay

(Khodosh et al., 2006)

located_in presynaptic active zone

inferred from direct assay

(Khodosh et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\bchs for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

bchs-RA

FBtr0079144

NM_135124

12155

3489

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

bchs-PA

FBpp0078775

389.8

3489

6.96

NP_608968

AAF52302

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bchs using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

bchs_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

adult head

(Simonsen et al., 2008)

Additional Descriptive Data

qRT-PCR of adult female heads assayed at weekly intervals shows that transcript levels decline significantly by 3 weeks and remain supressed.

(Simonsen et al., 2008)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 17

longitudinal connective

(Lim and Kraut, 2009)

embryonic/larval central nervous system

(Lim and Kraut, 2009)

embryonic stage

embryonic/larval muscle system

(Lim and Kraut, 2009)

aCC neuron

(Lim and Kraut, 2009)

RP2 motor neuron

(Lim and Kraut, 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

bchs protein is expressed in the embryonic CNS from stage 12 on. It is observed in the longitudinal connectives and in a subset of neuronal cell bodies that lie between the commissures including the aCC and RP2 motor neurons. It is also observed at low levels throughout the CNS, in muscles, and in some other tissues.

(Lim and Kraut, 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Finley et al., 2003)

located_in lysosome

inferred from direct assay

(Lim and Kraut, 2009)

located_in neuromuscular junction

inferred from direct assay

(Khodosh et al., 2006)

located_in presynaptic active zone

inferred from direct assay

(Khodosh et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\bchs in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\bchs

View exonic expression by tissue for Dmel\bchs

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0043362

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14001-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14001

Flygut - An atlas of the Drosophila adult midgut

FBgn0043362

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 36 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of bchs

Transgenic constructs containing regulatory region of bchs

Deletions and Duplications ( 7 )

Disrupted in

Df(2L)cl7

(Finley et al., 2003)

Df(2L)dsf3

(Finley et al., 2003)

Df(2L)dsf4

(Finley et al., 2003)

Df(2L)Exel6014

(Ryder, 2004.4.26)

Df(2L)Exel7024

(Ryder, 2004.4.26)

Df(2L)w3

(Finley et al., 2003)

Df(2L)w12

(Simonsen et al., 2007)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

bchs^GD6556

viable, with Scer\GAL4^Mef2.PR

bchs^GD6556

viable, with Scer\GAL4^pnr-MD237

bchs^GD6556

viable, with Scer\GAL4^tin.CΔ4

bchs^GD6556

viable (with Df(2L)Exel7024)

bchs^SH0148

Sterility

Allele

female fertile

female fertile, with Scer\GAL4^- :

bchs^EP2299

fertile

male fertile

male fertile, with Scer\GAL4^- :

bchs^EP2299

Other Phenotypes

Allele

decreased cell number | larval stage, with Scer\GAL4^eve.PU

bchs^UAS.1.GFP

decreased cell number | larval stage (with Df(2L)cl7)

immune response defective | adult stage | recessive

bchs⁵⁸

neuroanatomy defective, with Scer\GAL4^da.G32

bchs^VDRC.cUa

neuroanatomy defective, with Scer\GAL4^elav-C155

bchs^EP2299

neuroanatomy defective, with Scer\GAL4^GMR.PF

bchs^EP2299

neuroanatomy defective | adult stage

bchs⁵

neuroanatomy defective | adult stage (with bchs³)

bchs⁶

neuroanatomy defective | adult stage (with bchs⁶)

bchs³

neuroanatomy defective | adult stage (with Df(2L)cl7)

bchs³

neuroanatomy defective | adult stage (with Df(2L)cl7), with Scer\GAL4^- :

bchs^EP2299

neuroanatomy defective | larval stage, with Scer\GAL4^elav-C155

bchs^EP2299

neuroanatomy defective | larval stage (with Df(2L)cl7)

short lived

short lived, with Scer\GAL4^- :

bchs^EP2299

short lived (with Df(2L)cl7)

bchs³

short lived (with Df(2L)cl7), with Scer\GAL4^- :

bchs^EP2299

short lived | male (with bchs³)

bchs⁵

short lived | male (with bchs⁵)

bchs³

short lived | male (with Df(2L)cl7)

bchs³

visible, with Scer\GAL4^ap-md544

visible, with Scer\GAL4^GMR.PF

bchs^EP2299

visible, with Scer\GAL4^GMR.PU

bchs^EP2299

visible, with Scer\GAL4^sca-537.4

bchs^EP2299

wild-type

bchs^rev1

Phenotype manifest in

Allele

adult abdomen & microchaeta, with Scer\GAL4^sca-537.4

bchs^EP2299

adult central nervous system

bchs⁵

adult central nervous system, with Scer\GAL4^- :

bchs^EP2299

adult central nervous system (with Df(2L)cl7)

bchs³

adult central nervous system (with Df(2L)cl7), with Scer\GAL4^- :

bchs^EP2299

anterior fascicle & synapse, with Scer\GAL4^elav-C155

bchs^EP2299

autophagosome | larval stage, with bchs^17M/Df(2L)cl7, Scer\GAL4^eve.PU

bchs^UAS.1.GFP

autophagosome | larval stage, with Df(2L)cl7/bchs^58M, Scer\GAL4^eve.PU

bchs^UAS.1.GFP

autophagosome | larval stage (with Df(2L)cl7)

bchs^17M

autophagosome | larval stage (with Df(2L)cl7), with Scer\GAL4^eve.PU, bchs^UAS.1.GFP

brain (with Df(2L)cl7)

bchs³

deutocerebrum (with Df(2L)cl7)

bchs³

dorsocentral bristle, with Scer\GAL4^sca-537.4

bchs^EP2299

ellipsoid body (with Df(2L)cl7)

bchs³

embryonic/larval brain | third instar larval stage, with Scer\GAL4^elav-C155

bchs^EP2299

embryonic/larval brain | third instar larval stage (with Df(2L)cl7)

bchs⁵⁸

embryonic/larval neuron | larval stage (with Df(2L)cl7)

eye, with Scer\GAL4^GMR.PF

bchs^EP2299

eye, with Scer\GAL4^GMR.PU

bchs^EP2299

eye disc, with Scer\GAL4^da.G32

bchs^VDRC.cUa

fan-shaped body (with Df(2L)cl7)

bchs³

glial cell, with Scer\GAL4^da.G32

bchs^VDRC.cUa

growth cone, with Scer\GAL4^GMR.PF

bchs^EP2299

growth cone & eye photoreceptor cell, with Scer\GAL4^GMR.PF

bchs^EP2299

inclusion body | adult stage (with bchs³)

bchs⁶

inclusion body | adult stage (with bchs⁶)

bchs³

intersegmental nerve, with Scer\GAL4^elav-C155

bchs^EP2299

lamina (with Df(2L)cl7)

bchs³

medulla (with Df(2L)cl7)

bchs³

neurite | larval stage (with Df(2L)cl7)

bchs^17M

neuron & eye photoreceptor cell, with Scer\GAL4^GMR.PF

bchs^EP2299

neuron | adult stage (with bchs³)

bchs⁶

neuron | adult stage (with bchs⁶)

bchs³

ommatidium, with Scer\GAL4^GMR.PF

bchs^EP2299

ommatidium (with Df(2L)cl7)

bchs³

protocerebrum (with Df(2L)cl7)

bchs³

retina (with Df(2L)cl7)

bchs³

rhabdomere (with Df(2L)cl7)

bchs³

RP2 motor neuron | larval stage, with Scer\GAL4^eve.PU

bchs^UAS.1.GFP

RP2 motor neuron | larval stage (with Df(2L)cl7)

scutellar bristle, with Scer\GAL4^sca-537.4

bchs^EP2299

subesophageal ganglion (with Df(2L)cl7)

bchs³

vacuole | adult stage (with bchs³)

bchs⁶

vacuole | adult stage (with bchs⁶)

bchs³

vesicle | larval stage (with Df(2L)cl7)

wing, with Scer\GAL4^ap-md544

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\WDFY3

15 of 15

Yes

Hsap\WDFY4

7 of 15

Yes

Hsap\LYST

2 of 15

Hsap\NSMAF

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Wdfy3

15 of 15

Yes

Mmus\Wdfy4

7 of 15

Yes

Mmus\Lyst

2 of 15

Mmus\Nsmaf

2 of 15

Yes

Mmus\Wdr81

2 of 15

Mmus\Mab21l2

1 of 15

Mmus\Nbeal2

1 of 15

Rattus norvegicus (Norway rat) (7)

Rnor\Wdfy3

6 of 13

Yes

Rnor\Wdfy4

4 of 13

Yes

Rnor\Nsmaf

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (7)

Xtro\wdfy3

8 of 12

Yes

Xtro\lyst

2 of 12

Xtro\nsmaf

2 of 12

Yes

Xtro\wdfy4

2 of 12

Yes

Xtro\nbeal1

1 of 12

Xtro\nbeal2

1 of 12

Xtro\wdr81

1 of 12

Danio rerio (Zebrafish) (7)

Drer\wdfy3

9 of 15

Yes

Drer\wdfy4

7 of 15

Yes

Drer\nsmaf

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\wdfy-3

11 of 15

Yes

Cele\lyst-1

3 of 15

Yes

Cele\sel-2

1 of 15

Cele\sorf-2

1 of 15

Arabidopsis thaliana (thale-cress) (6)

Atha\AT4G02660

5 of 9

Yes

Atha\SPI

5 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\BPH1

7 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\lvs1

7 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919002B )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA25322

Drosophila persimilis

Dper\GL19042

Drosophila willistoni

Dwil\GK24135

Drosophila willistoni

Dwil\GK14704

Drosophila virilis

Dvir\GJ15404

Drosophila mojavensis

Dmoj\GI17530

Drosophila grimshawi

Dgri\GH11010

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915001C )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17006032

Glossina morsitans

Tsetse fly

Gmor\GMOY010447

Mayetiola destructor

Hessian fly

Mdes\Mdes004668

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009823

Anopheles darlingi

American malaria mosquito

Adar\ADAC005465

Anopheles gambiae

Malaria mosquito

Agam\AGAP012480

Anopheles gambiae

Malaria mosquito

Agam\AGAP012452

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W001X )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010373

Bombyx mori

Silkmoth

Bmor\BGIBMGA010372

Bombyx mori

Silkmoth

Bmor\BGIBMGA010371

Danaus plexippus

Monarch butterfly

Dple\DPOGS205809-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL011579

Apis florea

Little honeybee

Aflo\2211668340

Apis mellifera

Western honey bee

Amel\GB51344

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20071

Bombus terrestris

Buff-tailed bumblebee

Bter\15205947

Linepithema humile

Argentine ant

Lhum\LH10798

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001d4d

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010214

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02428

Tribolium castaneum

Red flour beetle

Tcas\TC000957

Pediculus humanus

Human body louse

Phum\PHUM221320

Rhodnius prolixus

Kissing bug

Rpro\RPRC015178

Cimex lectularius

Bed bug

Clec\CLEC001530

Cimex lectularius

Bed bug

Clec\CLEC001528

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002763

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16013

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16050

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16014

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14321

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X001T )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003916

Strigamia maritima

European centipede

Smar\SMAR006231

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56664.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56662.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56665.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56661.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g00910

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_241577

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G002Q )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Wdfy3_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Wdfy3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Wdfy3_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003863gn

Gallus gallus

Domestic chicken

Ggal\WDFY4

Gallus gallus

Domestic chicken

Ggal\WDFY3

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (3)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

bchs⁵⁸

model of primary autosomal dominant microcephaly 18

CEA

(Hebbar et al., 2015)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

WDFY3; WD repeat and FYVE domain containing 3

model of primary autosomal dominant microcephaly 18

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

bchs⁵⁸

model of primary autosomal dominant microcephaly 18

is exacerbated by CDase^UAS.cAa

(Hebbar et al., 2015)

is ameliorated by CDase^slab-2

(Hebbar et al., 2015)

is exacerbated by lace^k05305

(Hebbar et al., 2015)

is ameliorated by nSMase^EY00448

(Hebbar et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

WDFY3; WD repeat and FYVE domain containing 3

15 of 15

617485

MICROCEPHALY 18, PRIMARY, AUTOSOMAL DOMINANT; MCPH18

primary autosomal dominant microcephaly 18

WDFY4; WDFY family member 4

7 of 15

613316

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

bchs

enhanceable

Atg1

(Simonsen et al., 2007)

bchs

suppressible

Atg2

(Simonsen et al., 2007)

bchs

enhanceable

Atg6

(Simonsen et al., 2007)

enhanceable

(Sim et al., 2019)

suppressible

(Sim et al., 2019)

suppressible

(Simonsen et al., 2007)

bchs

enhanceable

Atg18a

(Simonsen et al., 2007)

bchs

enhanceable

btv

(Simonsen et al., 2007)

bchs

enhanceable

(Simonsen et al., 2007)

bchs

enhanceable

car

(Simonsen et al., 2007)

bchs

suppressible

Diap1

(Müller et al., 2005)

bchs

enhanceable

Dlic

(Simonsen et al., 2007)

bchs

enhanceable

dor

(Simonsen et al., 2007)

bchs

enhanceable

eff

(Simonsen et al., 2007)

bchs

enhanceable

Gga

(Luan et al., 2012, Eissenberg et al., 2011)

bchs

enhanceable

hook

(Simonsen et al., 2007)

bchs

enhanceable

Lerp

(Hasanagic et al., 2015)

bchs

enhanceable

lwr

(Simonsen et al., 2007)

bchs

enhanceable

(Simonsen et al., 2007)

bchs

enhanceable

Rab11

(Simonsen et al., 2007, Khodosh et al., 2006)

bchs

enhanceable

Rab32

(Simonsen et al., 2007)

bchs

enhanceable

Rop

(Simonsen et al., 2007)

bchs

enhanceable

smt3

(Simonsen et al., 2007)

bchs

enhanceable

spin

(Simonsen et al., 2007)

bchs

enhanceable

Syx1A

(Simonsen et al., 2007)

bchs

enhanceable

Syx13

(Simonsen et al., 2007)

bchs

enhanceable

Uba1

(Simonsen et al., 2007)

bchs

enhanceable

Usp7

(Simonsen et al., 2007)

bchs

enhanceable

αTub84B

(Simonsen et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Sim et al., 2019)

enhanceable

(Raymond et al., 2004)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

bchs

(Müller et al., 2005)

Ppt1

enhanceable

bchs

(Buff et al., 2007)

Rab11

suppressible

bchs

(Khodosh et al., 2006)

Rac1

enhanceable

bchs

(Raymond et al., 2004)

RacGAP84C

enhanceable

bchs

(Raymond et al., 2004)

Ras85D

enhanceable

bchs

(Raymond et al., 2004)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0043362

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33819

MIST (genetic) - An integrated Molecular Interaction Database

bchs

MIST (protein-protein) - An integrated Molecular Interaction Database

bchs

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-18

Cytogenetic map

26A1-26A1

Sequence location

2L:5,907,169..5,922,776 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

26A1-26A1

Limits computationally determined from genome sequence between P{lacW}l(2)k06502^k06502 and P{EP}bchs^EP2299&P{EP}Gpdh^EP466

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

26A1-26A2

(determined by in situ hybridisation)

(Abdelilah-Seyfried et al., 2000)

Experimentally Determined Recombination Data

Location

2-18

(FlyBase, 2016)

2-19.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Bloomington

43525

w^*; P{GSV1}bchs^s-529

51636

y¹ w^*; P{UAS-bchs.HA}32

42517

y¹ v¹; P{TRiP.HMJ02083}attP40

56639

y¹ w^*; Mi{MIC}bchs^MI11961

9887

y¹ w^*; P{EP}EP2299, bchs⁵⁸/CyO

9888

y¹ w^*; P{EP}EP2299, bchs¹⁷/CyO

85117

w¹¹¹⁸; PBac{RB}bchs^e00833 CG14000^e00833

59378

y¹ w^*; Mi{MIC}bchs^MI14478 CG14000^MI14478

Kyoto

126124

w¹¹¹⁸; P{RS5}bchs^5-SZ-3543

114485

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; PBac{RB}bchs^e00833 P{neoFRT}40A/CyO y⁺

VDRC

v110785

P{KK102172}VIE-260B

v45028

w¹¹¹⁸; P{GD6556}v45028

More stocks available...

Genomic Clones (26)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (7)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD12984

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0043362

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0043362

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33819

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lim and Kraut, 2009)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Beach1 bchs

(Finley, 2002.3.18)

Source for database merge of

Source for merge of: Beach1 CG9011 CG14001 EP2299

(Kraut et al., 2001, Kraut et al., 2001)

Source for merge of: Beach1 BcDNA:SD12984

(FlyBase, 1996-)

Additional comments

Source for merge of Beach1 BcDNA:SD12984 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Other Comments

bchs may have some role in determining cellular volume and/or proliferation in the brain.

(Kriston-Vizi et al., 2011)

Mutants demonstrate a reduced adult life span associated with age-dependent formation of protein aggregates throughout the CNS. Protein inclusions contain insoluble ubiquinated proteins and aggregates of Appl. Brains from older bchs mutants also show extensive neuronal apoptosis.

(Finley et al., 2002)

Identification: in a screen for genes which when overexpressed cause motorneuron pathfinding and or synaptogenesis errors.

(Kraut and Zinn, 2001)

Involved in endocytosis/membrane trafficking.

(Kraut and Zinn, 2001)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33819

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0043362

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

bchs_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14001

Flygut - An atlas of the Drosophila adult midgut

FBgn0043362

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33819

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000957

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG14001

modMine - A data warehouse for the modENCODE project

FBgn0043362

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VML2

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0043362

DRSC - Results frm RNAi screens

FBgn0043362

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0043362

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14001-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0043362

FlyMine - An integrated database for Drosophila genomics

FBgn0043362

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33819

MIST (genetic) - An integrated Molecular Interaction Database

bchs

MIST (protein-protein) - An integrated Molecular Interaction Database

bchs

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

Alfy

(Érdi et al., 2012)

BcDNA:SD12984

Bchs

(Lőrincz et al., 2016, Hasanagic et al., 2015, Liu et al., 2014, Luan et al., 2012, Nezis, 2012, Kim et al., 2010, Martin et al., 2007)

Beach1

(Raymond et al., 2004)

CG14001

(O'Farrell et al., 2017, Érdi et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Molnar et al., 2006, Finley et al., 2003)

CG9011

(Finley et al., 2003)

DBEACH1

(Kraut et al., 2001, Kraut et al., 2001)

EP2299

(Abdelilah-Seyfried et al., 2001, Abdelilah-Seyfried et al., 2000)

alfy

(Filimonenko et al., 2010)

bchd

beach

(Sim et al., 2019)

Name Synonyms

Beach1

(Finley, 2002.3.18, Kraut, 2002.3.6)

Beached

(Kraut and Zinn, 2002, Kraut and Zinn, 2001)

Beached 1

(Kraut, 2002.3.6)

Beached1

(Raymond et al., 2004)

Blue Cheese

(O'Farrell et al., 2017, Lőrincz et al., 2016, Nezis, 2012, Eissenberg et al., 2011)

Blue cheese

(Balakrishnan et al., 2015, Hasanagic et al., 2015, Liu et al., 2014, Mulakkal et al., 2014, Érdi et al., 2012, Nezis, 2012, Eissenberg et al., 2011, Kim et al., 2010, Buff et al., 2007)

beached

(Wright et al., 2005)

blue cheese

(Hebbar et al., 2015, Mulakkal et al., 2014, Nezis, 2012, Clausen et al., 2010, Filimonenko et al., 2010, Hortsch et al., 2010, Lim and Kraut, 2009, Kumarasamy et al., 2008, Simonsen et al., 2008, Finley et al., 2007, Korey et al., 2007, Simonsen et al., 2007, Khodosh et al., 2006, Beckstead et al., 2005, Finley and Kraut, 2004.4.16)

dbeach1

(Khodosh et al., 2003)

lyst

(Sorvina et al., 2020)

Secondary FlyBase IDs

FBgn0031748
FBgn0031750
FBgn0062881

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (96)

The following external sites may use different assemblies or annotations than FlyBase.

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