FB2019_05, released Oct 15, 2019

Gene: Dmel\cbt

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General Information
Symbol
Dmel\cbt
Species
D. melanogaster
Name
cabut
Annotation Symbol
CG4427
Feature Type
protein_coding_gene
FlyBase ID
FBgn0043364
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
cabut (cbt) encodes a transcription factor that controls Dpp signaling and is involved in dorsal closure and wing disc morphogenesis. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
EP2237, dTIEG
Key Links
Genomic Location
Cytogenetic map
21D1-21D1
Sequence location
2L:476,446..479,688 [-]
Recombination map
2-1
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
sequence-specific DNA binding
Predictions / Assertions
DNA-binding transcription factor activity, RNA polymerase II-specific
Summaries
Gene Group (FlyBase)
SP1/KLF TRANSCRIPTION FACTORS -
The Sp1/KLF (Sp1-like/Kruppel-like factors) family of zinc finger proteins are DNA binding proteins. They can act as activators or repressors and some members bind sequences within Polycomb Response Elements (PREs). (Adapted from FBrf0188187).
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Pathway (FlyBase)
Positive Regulators of BMP Signaling Pathway -
Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\cbt or the JBrowse view of Dmel\cbt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.42
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
cbt-RA
FBtr0078083
NM_164384
2041
428
cbt-RB
FBtr0078084
NM_134685
3243
347
cbt-RC
FBtr0310030
NM_001272903
2361
347
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
cbt-PA
FBpp0077743
46.7
428
9.28
NP_722636
AAF51489
cbt-PB
FBpp0077744
37.9
347
9.63
NP_608529
AAN10498
cbt-PC
FBpp0301733
37.9
347
9.63
NP_001259832
AGB92369
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

347 aa isoforms: cbt-PB, cbt-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cbt using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
sequence-specific DNA binding
inferred from direct assay
(Brown et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN001145452
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:11811
(Munoz-Descalzo et al., 2007)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
dorsal closure
inferred from mutant phenotype
(Munoz-Descalzo et al., 2005)
negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Belacortu et al., 2012)
positive regulation of BMP signaling pathway
inferred from mutant phenotype
(Rodriguez, 2011)
sensory organ development
inferred from mutant phenotype
(Abdelilah-Seyfried et al., 2000)
wing disc dorsal/ventral pattern formation
inferred from genetic interaction with FLYBASE:Bx; FB:FBgn0265598, FLYBASE:ap; FB:FBgn0267978
(Bejarano et al., 2008)
wing disc morphogenesis
inferred from mutant phenotype
(Rodriguez, 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001145452
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
nucleus
inferred from direct assay
(Belacortu et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001145452
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 3 -- 5
organism | ubiquitous
(Belacortu et al., 2011)
embryonic stage 12 -- 14
embryonic epidermis | lateral
(Belacortu et al., 2011)
embryonic/larval midgut primordium
(Belacortu et al., 2011)
embryonic hindgut
(Belacortu et al., 2011)
embryonic stage 13 -- 14
amnioserosa
(Belacortu et al., 2011)
embryonic stage 14
yolk nucleus
(Belacortu et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
cbt protein is nuclear and is first detected in the germ plasm and pole cells of syncytial embryos, and subsequently, in blastoderm stages and during gastrulation. During germband retraction and dorsal closure it is localized in the yolk cell nuclei, lateral epidermis, and the gut primordium/hindgut. It is also present in the amnioserosa at these stages, despite the mRNA not being detected in this tissue.
(Belacortu et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleus
inferred from direct assay
(Belacortu et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\cbt in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of cbt
Transgenic constructs containing regulatory region of cbt
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Bx-MS1096
lethal | cold sensitive, with Scer\GAL4Bx-MS1096
lethal - all die before end of embryonic stage
lethal - all die before end of embryonic stage | partially
partially lethal | conditional, with Scer\GAL4αTub84B.PL
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2L)BSC107)
viable | recessive, with Scer\GAL4- :
Other Phenotypes
Allele
cell polarity defective | embryonic stage
circadian rhythm defective | adult stage, with Scer\GAL4tim.PE
decreased occurrence of cell division | larval stage | conditional
developmental rate defective | conditional, with Scer\GAL4αTub84B.PL
increased cell number, with Scer\GAL4salm.EPv
locomotor behavior defective | adult stage, with Scer\GAL4tim.PE
neuroanatomy defective | larval stage, with Scer\GAL4elav-C155
neuroanatomy defective | pharate adult stage, with Scer\GAL4CCAP.PP
some die during embryonic stage
some die during embryonic stage | partially
visible, with Scer\GAL4hh.PU
visible, with Scer\GAL4salm.EPv
visible, with Scer\GAL4sca-537.4
visible, with Scer\GAL4sd.PU
Phenotype manifest in
Allele
1st posterior cell, with Scer\GAL4hh.PU
amnioserosa
anterior fascicle & synapse, with Scer\GAL4elav-C155
crossvein, with Scer\GAL4hh.PU
dorsocentral bristle, with Scer\GAL4sca-537.4
dorsocentral bristle | ectopic, with Scer\GAL4sca-537.4
embryo | dorsal closure stage
embryonic/first instar larval cuticle | anterior
embryonic/first instar larval cuticle | dorsal
embryonic leading edge cell
leading edge & filamentous actin
leading edge & muscle myosin complex
neurite | pharate adult stage, with Scer\GAL4CCAP.PP
ocellus, with Scer\GAL4sca-537.4
scutellar bristle, with Scer\GAL4sca-537.4
scutellar bristle | ectopic, with Scer\GAL4sca-537.4
tormogen cell, with Scer\GAL4sca-537.4
trichogen cell, with Scer\GAL4sca-537.4
trichogen cell | ectopic, with Scer\GAL4sca-537.4
wing, with Scer\GAL4salm.EPv
wing, with Scer\GAL4sd.PU
wing disc posterior compartment, with Scer\GAL4hh.PU
wing margin, with Scer\GAL4sd.PU
wing pouch, with Scer\GAL4salm.EPv
wing vein, with Scer\GAL4salm.EPv
wing vein L5, with Scer\GAL4sd.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (23)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KLF11
5 of 15
Yes
Yes
Hsap\KLF3
3 of 15
No
No
 
Hsap\KLF4
3 of 15
No
Yes
Hsap\KLF2
2 of 15
No
Yes
Hsap\KLF10
2 of 15
No
Yes
Hsap\EGR1
1 of 15
No
No
Hsap\EGR2
1 of 15
No
No
Hsap\EGR3
1 of 15
No
No
Hsap\EGR4
1 of 15
No
No
Hsap\KLF1
1 of 15
No
No
Hsap\KLF8
1 of 15
No
No
Hsap\KLF9
1 of 15
No
Yes
Hsap\KLF12
1 of 15
No
No
Hsap\KLF13
1 of 15
No
Yes
Hsap\KLF14
1 of 15
No
No
Hsap\KLF15
1 of 15
No
No
Hsap\KLF16
1 of 15
No
No
Hsap\OSR1
1 of 15
No
No
Hsap\OSR2
1 of 15
No
No
Hsap\SP2
1 of 15
No
No
Hsap\ZNF174
1 of 15
No
Yes
Hsap\ZNF362
1 of 15
No
No
Hsap\ZSCAN16
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Klf11
6 of 15
Yes
Yes
Mmus\Klf10
3 of 15
No
Yes
Mmus\Klf2
2 of 15
No
Yes
Mmus\Klf3
2 of 15
No
No
Mmus\Klf4
2 of 15
No
Yes
Mmus\Egr1
1 of 15
No
No
Mmus\Egr3
1 of 15
No
No
Mmus\Egr4
1 of 15
No
No
Mmus\Klf1
1 of 15
No
No
Mmus\Klf9
1 of 15
No
Yes
Mmus\Klf13
1 of 15
No
Yes
Mmus\Klf14
1 of 15
No
Yes
Mmus\Klf15
1 of 15
No
No
Mmus\Klf16
1 of 15
No
No
Mmus\Osr1
1 of 15
No
No
Mmus\Osr2
1 of 15
No
No
Mmus\Sp2
1 of 15
No
No
Mmus\Zfp174
1 of 15
No
Yes
Mmus\Zfp362
1 of 15
No
No
Rattus norvegicus (Norway rat) (11)
Rnor\Klf10
3 of 13
Yes
Yes
Rnor\Klf2
2 of 13
No
No
Rnor\Klf3
2 of 13
No
No
Rnor\Klf4
2 of 13
No
No
Rnor\Klf16
2 of 13
No
Yes
Rnor\Klf1
1 of 13
No
No
Rnor\Klf9
1 of 13
No
Yes
Rnor\Klf11
1 of 13
No
Yes
Rnor\Klf13
1 of 13
No
Yes
Rnor\Klf14
1 of 13
No
Yes
Rnor\Zfp362
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\klf11
4 of 12
Yes
Yes
Xtro\egr1
1 of 12
No
No
Xtro\egr2
1 of 12
No
No
Xtro\egr3
1 of 12
No
No
Xtro\klf2
1 of 12
No
Yes
Xtro\klf3
1 of 12
No
No
Xtro\klf4
1 of 12
No
No
Xtro\klf9
1 of 12
No
Yes
Xtro\klf10
1 of 12
No
Yes
Xtro\klf13
1 of 12
No
Yes
Xtro\klf15
1 of 12
No
No
Xtro\klf17
1 of 12
No
No
Xtro\osr1
1 of 12
No
No
Xtro\osr2
1 of 12
No
No
Xtro\sp2
1 of 12
No
Yes
Danio rerio (Zebrafish) (23)
Drer\klf11a
6 of 15
Yes
Yes
Drer\klf11b
3 of 15
No
Yes
Drer\klf2a
2 of 15
No
Yes
Drer\klf2b
2 of 15
No
Yes
Drer\klf4
2 of 15
No
Yes
Drer\klf17
2 of 15
No
Yes
Drer\egr1
1 of 15
No
No
Drer\egr2b
1 of 15
No
No
Drer\egr4
1 of 15
No
No
Drer\klf1
1 of 15
No
No
Drer\klf3
1 of 15
No
No
Drer\klf5a
1 of 15
No
No
Drer\klf5b
1 of 15
No
No
Drer\klf8
1 of 15
No
No
Drer\klf9
1 of 15
No
Yes
Drer\klf13
1 of 15
No
Yes
Drer\klf15
1 of 15
No
No
Drer\osr1
1 of 15
No
No
Drer\osr2
1 of 15
No
No
Drer\si:ch211-117k10.3
1 of 15
No
No
Drer\sp2
1 of 15
No
No
Drer\zgc:153115
1 of 15
No
Yes
Drer\znf362b
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\egrh-3
2 of 15
Yes
Yes
Cele\egrh-1
1 of 15
No
No
Cele\klf-1
1 of 15
No
No
Cele\klf-2
1 of 15
No
No
Cele\klf-3
1 of 15
No
No
Cele\klu-1
1 of 15
No
No
Cele\odd-1
1 of 15
No
No
Cele\odd-2
1 of 15
No
No
Cele\sptf-2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (10)
Scer\FZF1
3 of 15
Yes
No
Scer\ACE2
1 of 15
No
Yes
Scer\AZF1
1 of 15
No
No
Scer\CMR3
1 of 15
No
Yes
Scer\CRZ1
1 of 15
No
No
Scer\MSN2
1 of 15
No
No
Scer\MSN4
1 of 15
No
No
Scer\RPN4
1 of 15
No
Yes
Scer\SWI5
1 of 15
No
No
Scer\YPR015C
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\hsr1
2 of 12
Yes
Yes
Spom\prz1
2 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190FV7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\cbt
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000052
Drosophila simulans
Dsim\cbt
Drosophila sechellia
Dsec\cbt
Drosophila erecta
Dere\cbt
Drosophila yakuba
Dyak\cbt
Drosophila ananassae
Dana\cbt
Drosophila pseudoobscura pseudoobscura
Dpse\cbt
Drosophila persimilis
Dper\cbt
Drosophila willistoni
Dwil\cbt
Drosophila virilis
Dvir\cbt
Drosophila mojavensis
Dmoj\cbt
Drosophila grimshawi
Dgri\cbt
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150B3G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017893
Musca domestica
House fly
Mdoa\17012756
Glossina morsitans
Tsetse fly
Gmor\GMOY000834
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10627
Mayetiola destructor
Hessian fly
Mdes\Mdes015736
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006609
Anopheles gambiae
Malaria mosquito
Agam\AGAP009889
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015908
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FYT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006120
Danaus plexippus
Monarch butterfly
Dple\DPOGS201573-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002401
Apis florea
Little honeybee
Aflo\4077925124
Apis mellifera
Western honey bee
Amel\LOC410326
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15122
Bombus terrestris
Buff-tailed bumblebee
Bter\15212385
Linepithema humile
Argentine ant
Lhum\LH19421
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0028b7
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003308
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06283
Tribolium castaneum
Red flour beetle
Tcas\TC014124
Pediculus humanus
Human body louse
Phum\PHUM248360
Rhodnius prolixus
Kissing bug
Rpro\RPRC001510
Cimex lectularius
Bed bug
Clec\CLEC005479
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13361
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FYV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW022767
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61468.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g01530
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312628
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G1BN0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf2/4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf3/8/12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf11
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006082
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014976
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001563
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014590
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012142
Gallus gallus
Domestic chicken
Ggal\LOC422310
Gallus gallus
Domestic chicken
Ggal\KLF12
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028383
Gallus gallus
Domestic chicken
Ggal\KLF6
Gallus gallus
Domestic chicken
Ggal\KLF10
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000373
Gallus gallus
Domestic chicken
Ggal\KLF2
Gallus gallus
Domestic chicken
Ggal\KLF7
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026928
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027374
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026590
Gallus gallus
Domestic chicken
Ggal\KLF11
Gallus gallus
Domestic chicken
Ggal\KLF3
Gallus gallus
Domestic chicken
Ggal\KLF5
Gallus gallus
Domestic chicken
Ggal\KLF1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (13)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
btd
2 of 10
Klf15
2 of 10
luna
2 of 10
Sp1
2 of 10
Spps
2 of 10
sr
2 of 10
bowl
1 of 10
CG42741
1 of 10
dar1
1 of 10
hkb
1 of 10
ken
1 of 10
l(3)neo38
1 of 10
odd
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    KLF11; Kruppel like factor 11
    model of  maturity-onset diabetes of the young type 7
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KLF11; Kruppel like factor 11
    5 of 15
    603301
    KLF3; Kruppel like factor 3
    3 of 15
    609392
         
        KLF4; Kruppel like factor 4
        3 of 15
        602253
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Bx
            suppressible
            cbt
            (Bejarano et al., 2008)
            Bx|ap
            suppressible
            cbt
            (Bejarano et al., 2008)
            hep
            suppressible
            cbt
            (Munoz-Descalzo et al., 2005)
            pnr
            enhanceable
            cbt
            (Pena-Rangel et al., 2002)
            tkv
            suppressible
            cbt
            (Rodriguez, 2011)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            Positive Regulators of BMP Signaling Pathway -
            Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
            External Data
            Linkouts
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-1
            Cytogenetic map
            21D1-21D1
            Sequence location
            2L:476,446..479,688 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            21D1-21D1
            Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            21C4-21C6
            (determined by in situ hybridisation)
            (Abdelilah-Seyfried et al., 2000)
            Experimentally Determined Recombination Data
            Location
            2-1
            (FlyBase, 2016)
            2-0.0
            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (11)
            Genomic Clones (15)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (51)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            polyclonal
            (Belacortu et al., 2011)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for identity of: cabut EP2237
            (Munoz, 2004.2.25)
            Source for database merge of
            Source for merge of: EP2237 CG4427
            (Kraut et al., 2001, Kraut et al., 2001)
            Additional comments
            Other Comments
            dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation.
            (Guertin et al., 2006)
            Molecular and genetic analyses show that cbt expression is dependent on the JNK cascade during dorsal closure, and functions downstream of Jra to regulate dpp expression in the leading edge cells.
            (Munoz-Descalzo et al., 2005)
            cbt is essential for dorsal closure.
            (Munoz-Descalzo et al., 2004)
            Embryos mutant for cbt do not complete embryogenesis and frequently have holes in the dorsal-anterior region of their cuticles. The polarization of the dorsal-most epidermal cells in dorsal closure and also the activation of the JNK cascade at the leading edge cells is affected in cbt mutants.
            (Munoz-Descalzo et al., 2004)
            Identification: in a gain-of-function screen for genes involved in the generation of planar cell polarity.
            (Munoz-Descalzo et al., 2003)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 44 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (11)
            Reported As
            Symbol Synonym
            CG4427
            (Meadows, 2017.1.11, Ni et al., 2010.12.1, Fujikawa et al., 2009, Ida et al., 2009, Guertin et al., 2006, Molnar et al., 2006, Brown et al., 2005, Munoz-Descalzo et al., 2005, Rodriguez and Guerrero, 2005, Lim et al., 2004, Munoz, 2004.2.25, Wheeler et al., 2004)
            Cabot
            (Brown et al., 2005)
            Cabut
            (Chng et al., 2017, Ragheb et al., 2017, Beckstead et al., 2005)
            Cbt
            (Yaniv and Schuldiner, 2016)
            EP(2)2237
            (Pena-Rangel et al., 2002)
            EP2237
            (Chen et al., 2008, Yatsu et al., 2008, Kadener et al., 2007, Birch-Machin et al., 2005, Suske et al., 2005, Wheeler et al., 2004, Gorski et al., 2003, Zinke et al., 2002, Kraut et al., 2001, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000, Zou et al., 2000)
            cabut
            (Havula et al., 2013, Beckstead et al., 2005)
            cbt
            (Shokri et al., 2019, Sarov et al., 2016, Bartok et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Luck et al., 2014, Carter, 2013, de Celis et al., 2013.9.11, Awofala et al., 2012, Zhou et al., 2012, Abruzzi et al., 2011, Belacortu et al., 2011, Rodriguez, 2011, Truscott et al., 2011, Blanco et al., 2010, Nagoshi et al., 2010, Wasbrough et al., 2010, Dworkin et al., 2009, Fujikawa et al., 2009, Ida et al., 2009, Bushati et al., 2008, Khokhar et al., 2008, Lee et al., 2008, Zhao et al., 2008, Belacortu et al., 2007, Isogai et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Munoz-Descalzo et al., 2007)
            dTIEG
            (Rodriguez, 2011, Rodriguez and Guerrero, 2005)
            Name Synonyms
            Cabut
            (Bartok et al., 2015, Belacortu et al., 2011)
            TGF-beta-inducible early gene
            (Rodriguez and Guerrero, 2005)
            cabot
            (Brown et al., 2005)
            cabut
            (Havula and Hietakangas, 2018, Signor and Nuzhdin, 2018, Mattila and Hietakangas, 2017, Belacortu et al., 2011, Rodriguez, 2011, Bülow et al., 2010, Lebo et al., 2009, Bejarano et al., 2008, Zhao et al., 2008, Belacortu et al., 2007, Molnar et al., 2006, Morozova et al., 2006)
            Secondary FlyBase IDs
            • FBgn0031259
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (107)