• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\cbt

General Information
Symbol	Dmel\cbt	Species	D. melanogaster
Name	cabut	Annotation symbol	CG4427
Feature type	protein_coding_gene	FlyBase ID	FBgn0043364
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	EP2237
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	21D1-21D1	Sequence location	2L:476,446..479,682 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cabut is referred to in FlyBase by the symbol Dmel\cbt (CG4427, FBgn0043364). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: dorsal closure; sensory organ development; wing disc dorsal/ventral pattern formation; autophagic cell death; salivary gland cell autophagic cell death. 9 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; trichogen cell; dorsocentral bristle; amnioserosa; ocellus; tormogen cell; scutellar bristle; embryonic leading edge cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1623605_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of cbt. Gene sequence location is 2L:476446..479682.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Chen et al., 2008, PLoS Comput. Biol. 4(2): e1000026 Truscott et al., 2011, Genes Dev. 25(17): 1820--1834 Polypeptides cbt-PC Transcripts cbt-RC
FB2012_01	References Rodriguez, 2011, PLoS ONE 6(4): e18418 Sequence features BKN28762 HFA00655 Controlled Vocabulary Terms sequence-specific DNA binding RNA polymerase II transcription factor activity sequence-specific DNA binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21D1-21D1   Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
Experimentally Determined Cytological Location
Cytogenetic map Notes References 21C4-21C6   (determined by in situ hybridisation)   (Abdelilah-Seyfried et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cbt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cbt-RA FBtr0078083  NM_164384   2035   428 cbt-RB FBtr0078084  NM_134685   3237   347 cbt-RC FBtr0310030     2355   347
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cbt-PA   FBpp0077743   46.7   428   9.28     NP_722636   AAF51489 cbt-PB   FBpp0077744   37.9   347   9.63     NP_608529   AAN10498 cbt-PC   FBpp0301733   37.9   347   9.63
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51489   AE014134 AAN10498   AI295427   AI533768   AI533769   AJ749862 CAG44484   AQ254840   AW944434   AY061602 AAL29150   BI227840   BI238199   BI239081   BI365174   BI372168   BI372364   BI569709   BI571400   BI571522   BI572194   BI574334   BI584794   BI588034   BI591893   BI591930   BI604511   BI606214   BI619451   BI623346   BI628160   BP550324   BP550325   BP557087   BT025196   BT099918   CA805108   CA806500   CA806958   CO177353   CO187714   CO194760   CO266499   CO297485   CO302335   CO302604   CO309700   CO337760   CO344612   CZ466932   CZ467222   EC062385   EC072476   EC072921   EC075987   EC199103   EC201696   EC205696   EC212603   EC213082   EC213297   EC234238   EC234539   EC241535   EC246240   EC266157   EL881842   EL882188   EV579474   EV598663   GH784753   GH805968   GH814750   GH826849   GH836144
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q4R0P9 Q8IPV7 Q95R58 Q9VPQ5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0043364    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0043364 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0043364 expression level Developmental Stage   Expression Level embryo 00-02hr    1129 embryo 02-04hr    85 embryo 04-06hr    258 embryo 06-08hr    1003 embryo 08-10hr    2823 embryo 10-12hr    1521 embryo 12-14hr    1952 embryo 14-16hr    1320 embryo 16-18hr    3124 embryo 18-20hr    5160 embryo 20-22hr    3038 embryo 22-24hr    3297 larva L1    1418 larva L2    1329 larva L3 12hr old    1068 larva L3 puffstage 1-2    1046 larva L3 puffstage 3-6    1715 larva L3 puffstage 7-9    2998 white prepupae new    1106 white prepupae 12hr    2355 white prepupae 24hr    607 pupae 2d postWPP    727 pupae 3d postWPP    795 pupae 4d postWPP    1246 adult male 01day    1208 adult male 05day    1404 adult male 30day    1156 adult female 01day    1220 adult female 05day    1666 adult female 30day    1590 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1129) embryo 02-04hr    85 embryo 04-06hr  (258) embryo 06-08hr  (1003) embryo 08-10hr  (2823) embryo 10-12hr  (1521) embryo 12-14hr  (1952) embryo 14-16hr  (1320) embryo 16-18hr  (3124) embryo 18-20hr  (5160) embryo 20-22hr  (3038) embryo 22-24hr  (3297) larva L1  (1418) larva L2  (1329) larva L3 12hr old  (1068) larva L3 puffstage 1-2  (1046) larva L3 puffstage 3-6  (1715) larva L3 puffstage 7-9  (2998) white prepupae new  (1106) white prepupae 12hr  (2355) white prepupae 24hr  (607) pupae 2d postWPP  (727) pupae 3d postWPP  (795) pupae 4d postWPP  (1246) adult male 01day  (1208) adult male 05day  (1404) adult male 30day  (1156) adult female 01day  (1220) adult female 05day  (1666) adult female 30day  (1590) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1129 embryo 02-04hr    85 embryo 04-06hr    258 embryo 06-08hr    1003 embryo 08-10hr  (2823) embryo 10-12hr  (1521) embryo 12-14hr  (1952) embryo 14-16hr    1320 embryo 16-18hr  (3124) embryo 18-20hr  (5160) embryo 20-22hr  (3038) embryo 22-24hr  (3297) larva L1  1418 larva L2    1329 larva L3 12hr old    1068 larva L3 puffstage 1-2    1046 larva L3 puffstage 3-6  (1715) larva L3 puffstage 7-9  (2998) white prepupae new    1106 white prepupae 12hr  (2355) white prepupae 24hr    607 pupae 2d postWPP    727 pupae 3d postWPP    795 pupae 4d postWPP    1246 adult male 01day    1208 adult male 05day  1404 adult male 30day    1156 adult female 01day    1220 adult female 05day  (1666) adult female 30day  (1590) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1129 embryo 02-04hr    85 embryo 04-06hr    258 embryo 06-08hr    1003 embryo 08-10hr    2823 embryo 10-12hr    1521 embryo 12-14hr    1952 embryo 14-16hr    1320 embryo 16-18hr    3124 embryo 18-20hr    5160 embryo 20-22hr    3038 embryo 22-24hr    3297 larva L1    1418 larva L2    1329 larva L3 12hr old    1068 larva L3 puffstage 1-2    1046 larva L3 puffstage 3-6    1715 larva L3 puffstage 7-9    2998 white prepupae new    1106 white prepupae 12hr    2355 white prepupae 24hr    607 pupae 2d postWPP    727 pupae 3d postWPP    795 pupae 4d postWPP    1246 adult male 01day    1208 adult male 05day    1404 adult male 30day    1156 adult female 01day    1220 adult female 05day    1666 adult female 30day    1590 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1129 embryo 02-04hr    85 embryo 04-06hr    258 embryo 06-08hr    1003 embryo 08-10hr    2823 embryo 10-12hr    1521 embryo 12-14hr    1952 embryo 14-16hr    1320 embryo 16-18hr    3124 embryo 18-20hr    5160 embryo 20-22hr    3038 embryo 22-24hr    3297 larva L1    1418 larva L2    1329 larva L3 12hr old    1068 larva L3 puffstage 1-2    1046 larva L3 puffstage 3-6    1715 larva L3 puffstage 7-9    2998 white prepupae new    1106 white prepupae 12hr    2355 white prepupae 24hr    607 pupae 2d postWPP    727 pupae 3d postWPP    795 pupae 4d postWPP    1246 adult male 01day    1208 adult male 05day    1404 adult male 30day    1156 adult female 01day    1220 adult female 05day    1666 adult female 30day    1590 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0043364 expression level Developmental Stage   Expression Level embryo 00-02hr    1129 embryo 02-04hr    85 embryo 04-06hr    258 embryo 06-08hr    1003 embryo 08-10hr    2823 embryo 10-12hr    1521 embryo 12-14hr    1952 embryo 14-16hr    1320 embryo 16-18hr    3124 embryo 18-20hr    5160 embryo 20-22hr    3038 embryo 22-24hr    3297 larva L1    1418 larva L2    1329 larva L3 12hr old    1068 larva L3 puffstage 1-2    1046 larva L3 puffstage 3-6    1715 larva L3 puffstage 7-9    2998 white prepupae new    1106 white prepupae 12hr    2355 white prepupae 24hr    607 pupae 2d postWPP    727 pupae 3d postWPP    795 pupae 4d postWPP    1246 adult male 01day    1208 adult male 05day    1404 adult male 30day    1156 adult female 01day    1220 adult female 05day    1666 adult female 30day    1590 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1129) embryo 02-04hr    85 embryo 04-06hr  (258) embryo 06-08hr  (1003) embryo 08-10hr  (2823) embryo 10-12hr  (1521) embryo 12-14hr  (1952) embryo 14-16hr  (1320) embryo 16-18hr  (3124) embryo 18-20hr  (5160) embryo 20-22hr  (3038) embryo 22-24hr  (3297) larva L1  (1418) larva L2  (1329) larva L3 12hr old  (1068) larva L3 puffstage 1-2  (1046) larva L3 puffstage 3-6  (1715) larva L3 puffstage 7-9  (2998) white prepupae new  (1106) white prepupae 12hr  (2355) white prepupae 24hr  (607) pupae 2d postWPP  (727) pupae 3d postWPP  (795) pupae 4d postWPP  (1246) adult male 01day  (1208) adult male 05day  (1404) adult male 30day  (1156) adult female 01day  (1220) adult female 05day  (1666) adult female 30day  (1590) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1129 embryo 02-04hr    85 embryo 04-06hr    258 embryo 06-08hr    1003 embryo 08-10hr  (2823) embryo 10-12hr  1521 embryo 12-14hr  1952 embryo 14-16hr    1320 embryo 16-18hr  (3124) embryo 18-20hr  (5160) embryo 20-22hr  (3038) embryo 22-24hr  (3297) larva L1  1418 larva L2    1329 larva L3 12hr old    1068 larva L3 puffstage 1-2    1046 larva L3 puffstage 3-6  1715 larva L3 puffstage 7-9  (2998) white prepupae new    1106 white prepupae 12hr  2355 white prepupae 24hr    607 pupae 2d postWPP    727 pupae 3d postWPP    795 pupae 4d postWPP    1246 adult male 01day    1208 adult male 05day  1404 adult male 30day    1156 adult female 01day    1220 adult female 05day  1666 adult female 30day  1590 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1129 embryo 02-04hr    85 embryo 04-06hr    258 embryo 06-08hr    1003 embryo 08-10hr    2823 embryo 10-12hr    1521 embryo 12-14hr    1952 embryo 14-16hr    1320 embryo 16-18hr    3124 embryo 18-20hr    5160 embryo 20-22hr    3038 embryo 22-24hr    3297 larva L1    1418 larva L2    1329 larva L3 12hr old    1068 larva L3 puffstage 1-2    1046 larva L3 puffstage 3-6    1715 larva L3 puffstage 7-9    2998 white prepupae new    1106 white prepupae 12hr    2355 white prepupae 24hr    607 pupae 2d postWPP    727 pupae 3d postWPP    795 pupae 4d postWPP    1246 adult male 01day    1208 adult male 05day    1404 adult male 30day    1156 adult female 01day    1220 adult female 05day    1666 adult female 30day    1590 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1129 embryo 02-04hr    85 embryo 04-06hr    258 embryo 06-08hr    1003 embryo 08-10hr    2823 embryo 10-12hr    1521 embryo 12-14hr    1952 embryo 14-16hr    1320 embryo 16-18hr    3124 embryo 18-20hr    5160 embryo 20-22hr    3038 embryo 22-24hr    3297 larva L1    1418 larva L2    1329 larva L3 12hr old    1068 larva L3 puffstage 1-2    1046 larva L3 puffstage 3-6    1715 larva L3 puffstage 7-9    2998 white prepupae new    1106 white prepupae 12hr    2355 white prepupae 24hr    607 pupae 2d postWPP    727 pupae 3d postWPP    795 pupae 4d postWPP    1246 adult male 01day    1208 adult male 05day    1404 adult male 30day    1156 adult female 01day    1220 adult female 05day    1666 adult female 30day    1590 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0043364    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0043364 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0043364 expression level Tissue   Expression Level Larval Central Nervous System    268.4 Larval Midgut    742.3 Larval Hindgut    726.1 Larval Malpighian Tubules    1282.4 Larval Fat Body    776.9 Larval Salivary Gland    412.9 Larval Trachea    591.5 Larval Carcass    777.725 Adult Head    805.3 Adult Eye    751.325 Adult Brain    599.5 Adult Thoracic-Abdominal Ganglion    460.2 Adult Crop    1430.1 Adult Midgut    837.2 Adult Hindgut    950 Adult Malpighian Tubules    924.2 Adult Fat Body    1386.7 Adult Salivary Gland    1226.3 Adult Heart    1014.525 Adult VirginFemale Spermatheca    1130.3 Adult InseminatedFemale Spermatheca    1194.1 Adult Ovary    382.3 Adult Testis    44.6 Adult Male Accessory Gland    101.2 Adult Carcass    820.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    268.4 Larval Midgut  (742.3) Larval Hindgut  (726.1) Larval Malpighian Tubules  (1282.4) Larval Fat Body  (776.9) Larval Salivary Gland    412.9 Larval Trachea  (591.5) Larval Carcass  (777.725) Adult Head  (805.3) Adult Eye  (751.325) Adult Brain  (599.5) Adult Thoracic-Abdominal Ganglion    460.2 Adult Crop  (1430.1) Adult Midgut  (837.2) Adult Hindgut  (950) Adult Malpighian Tubules  (924.2) Adult Fat Body  (1386.7) Adult Salivary Gland  (1226.3) Adult Heart  (1014.525) Adult VirginFemale Spermatheca  (1130.3) Adult InseminatedFemale Spermatheca  (1194.1) Adult Ovary    382.3 Adult Testis    44.6 Adult Male Accessory Gland    101.2 Adult Carcass  (820.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    268.4 Larval Midgut    742.3 Larval Hindgut    726.1 Larval Malpighian Tubules  (1282.4) Larval Fat Body    776.9 Larval Salivary Gland    412.9 Larval Trachea    591.5 Larval Carcass    777.725 Adult Head    805.3 Adult Eye    751.325 Adult Brain    599.5 Adult Thoracic-Abdominal Ganglion    460.2 Adult Crop  (1430.1) Adult Midgut    837.2 Adult Hindgut    950 Adult Malpighian Tubules    924.2 Adult Fat Body  (1386.7) Adult Salivary Gland  (1226.3) Adult Heart  1014.525 Adult VirginFemale Spermatheca  (1130.3) Adult InseminatedFemale Spermatheca  (1194.1) Adult Ovary    382.3 Adult Testis    44.6 Adult Male Accessory Gland    101.2 Adult Carcass    820.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    268.4 Larval Midgut    742.3 Larval Hindgut    726.1 Larval Malpighian Tubules    1282.4 Larval Fat Body    776.9 Larval Salivary Gland    412.9 Larval Trachea    591.5 Larval Carcass    777.725 Adult Head    805.3 Adult Eye    751.325 Adult Brain    599.5 Adult Thoracic-Abdominal Ganglion    460.2 Adult Crop    1430.1 Adult Midgut    837.2 Adult Hindgut    950 Adult Malpighian Tubules    924.2 Adult Fat Body    1386.7 Adult Salivary Gland    1226.3 Adult Heart    1014.525 Adult VirginFemale Spermatheca    1130.3 Adult InseminatedFemale Spermatheca    1194.1 Adult Ovary    382.3 Adult Testis    44.6 Adult Male Accessory Gland    101.2 Adult Carcass    820.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0043364 expression level Tissue   Expression Level Larval Central Nervous System    268.4 Larval Midgut    742.3 Larval Hindgut    726.1 Larval Malpighian Tubules    1282.4 Larval Fat Body    776.9 Larval Salivary Gland    412.9 Larval Trachea    591.5 Larval Carcass    777.725 Adult Head    805.3 Adult Eye    751.325 Adult Brain    599.5 Adult Thoracic-Abdominal Ganglion    460.2 Adult Crop    1430.1 Adult Midgut    837.2 Adult Hindgut    950 Adult Malpighian Tubules    924.2 Adult Fat Body    1386.7 Adult Salivary Gland    1226.3 Adult Heart    1014.525 Adult VirginFemale Spermatheca    1130.3 Adult InseminatedFemale Spermatheca    1194.1 Adult Ovary    382.3 Adult Testis    44.6 Adult Male Accessory Gland    101.2 Adult Carcass    820.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    268.4 Larval Midgut  742.3 Larval Hindgut  726.1 Larval Malpighian Tubules  (1282.4) Larval Fat Body  776.9 Larval Salivary Gland    412.9 Larval Trachea  591.5 Larval Carcass  777.725 Adult Head  805.3 Adult Eye  751.325 Adult Brain  599.5 Adult Thoracic-Abdominal Ganglion    460.2 Adult Crop  (1430.1) Adult Midgut  (837.2) Adult Hindgut  (950) Adult Malpighian Tubules  (924.2) Adult Fat Body  (1386.7) Adult Salivary Gland  (1226.3) Adult Heart  (1014.525) Adult VirginFemale Spermatheca  (1130.3) Adult InseminatedFemale Spermatheca  (1194.1) Adult Ovary    382.3 Adult Testis    44.6 Adult Male Accessory Gland    101.2 Adult Carcass  (820.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    268.4 Larval Midgut    742.3 Larval Hindgut    726.1 Larval Malpighian Tubules  1282.4 Larval Fat Body    776.9 Larval Salivary Gland    412.9 Larval Trachea    591.5 Larval Carcass    777.725 Adult Head    805.3 Adult Eye    751.325 Adult Brain    599.5 Adult Thoracic-Abdominal Ganglion    460.2 Adult Crop  1430.1 Adult Midgut    837.2 Adult Hindgut    950 Adult Malpighian Tubules    924.2 Adult Fat Body  1386.7 Adult Salivary Gland  1226.3 Adult Heart  1014.525 Adult VirginFemale Spermatheca  1130.3 Adult InseminatedFemale Spermatheca  1194.1 Adult Ovary    382.3 Adult Testis    44.6 Adult Male Accessory Gland    101.2 Adult Carcass    820.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    268.4 Larval Midgut    742.3 Larval Hindgut    726.1 Larval Malpighian Tubules    1282.4 Larval Fat Body    776.9 Larval Salivary Gland    412.9 Larval Trachea    591.5 Larval Carcass    777.725 Adult Head    805.3 Adult Eye    751.325 Adult Brain    599.5 Adult Thoracic-Abdominal Ganglion    460.2 Adult Crop    1430.1 Adult Midgut    837.2 Adult Hindgut    950 Adult Malpighian Tubules    924.2 Adult Fat Body    1386.7 Adult Salivary Gland    1226.3 Adult Heart    1014.525 Adult VirginFemale Spermatheca    1130.3 Adult InseminatedFemale Spermatheca    1194.1 Adult Ovary    382.3 Adult Testis    44.6 Adult Male Accessory Gland    101.2 Adult Carcass    820.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    805.3   NA  Eye    751.325   NA  Brain    599.5   268.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    460.2   NA  Crop    1430.1   742.3  Midgut    837.2   726.1  Hindgut    950   1282.4  Malpighian Tubules    924.2   776.9  Fat Body    1386.7   412.9  Salivary Gland    1226.3   NA  Heart    1014.525   591.5  Trachea    NA   NA  VirginFemale Spermatheca    1130.3   NA  InseminatedFemale Spermatheca    1194.1   NA  Ovary    382.3   NA  Testis    44.6   NA  Male Accessory Gland    101.2   777.725  Carcass    820.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043364 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4427-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for cbt Stages(s) 1-3 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage cbtEP2237E1 lethal | embryonic stage | partially cbtEP2237E28 viable, with Scer\GAL4pnr-MD237 cbtGD5044 viable | recessive, with Scer\GAL4[-]: cbtEP2237 Other Phenotypes Allele cell polarity defective | embryonic stage cbtEP2237E1 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 cbtEP2237 neuroanatomy defective | pharate adult stage, with Scer\GAL4Ccap.PP cbtEP2237 visible, with Scer\GAL4sca-537.4 cbtEP2237 Phenotype manifest in Allele amnioserosa cbtEP2237E1 anterior fascicle & synapse, with Scer\GAL4elav-C155 cbtEP2237 dorsal closure embryo cbtEP2237E1 dorsocentral bristle, with Scer\GAL4sca-537.4 cbtEP2237 dorsocentral bristle | ectopic, with Scer\GAL4sca-537.4 cbtEP2237 embryonic/first instar larval cuticle | anterior cbtEP2237E28 embryonic/first instar larval cuticle | dorsal cbtEP2237E1 embryonic leading edge cell cbtEP2237E1 leading edge & filamentous actin cbtEP2237E1 leading edge & muscle myosin complex cbtEP2237E1 neurite | pharate adult stage, with Scer\GAL4Ccap.PP cbtEP2237 ocellus, with Scer\GAL4sca-537.4 cbtEP2237 scutellar bristle, with Scer\GAL4sca-537.4 cbtEP2237 scutellar bristle | ectopic, with Scer\GAL4sca-537.4 cbtEP2237 tormogen cell, with Scer\GAL4sca-537.4 cbtEP2237 trichogen cell, with Scer\GAL4sca-537.4 cbtEP2237 trichogen cell | ectopic, with Scer\GAL4sca-537.4 cbtEP2237
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of cbt Class Mutagen Stocks Known lesion cbtc01139 piggyBac transposase 1 -- cbtNP5201 1 -- cbtc01512 piggyBac transposase 0 -- cbtEP2-408 0 -- cbtEP2237 P-element activity 0 Yes cbtEP2237E1 loss of function allele Delta2-3 0 Yes cbtEP2237E28 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cbt Class Mutagen Stocks Known lesion cbtGD5044 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cbtScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5044} NA P{UAS-cbt.M} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH2103SH2103 No insertion of enhancer trap binary system P{GAL4}prx1 No P{GawB}cbtNP5201 No miscellaneous insertions P{EP}cbtEP2237E28 NA P{GT1}BG02687 NA PBac{PB}cbtc01139 NA PBac{PB}cbtc01512 NA insertion of mobile activating element P{EP}cbtEP2-408 NA P{EP}cbtEP2237 NA P{GSV1}C480C480 NA P{GSV1}GSd226GSd226 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from direct assay (Brown et al., 2005)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) dorsal closure inferred from mutant phenotype (Munoz-Descalzo et al., 2005) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003) sensory organ development inferred from mutant phenotype (Abdelilah-Seyfried et al., 2000) wing disc dorsal/ventral pattern formation inferred from genetic interaction with Bx, ap (Bejarano et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding RNA polymerase II transcription factor activity inferred from sequence or structural similarity with human KLF11 (Munoz-Descalzo et al., 2007) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
dorsal closure non-traceable author statement (Munoz-Descalzo et al., 2004, Munoz-Descalzo et al., 2003) establishment of planar polarity non-traceable author statement (Munoz-Descalzo et al., 2003) eye morphogenesis non-traceable author statement (Munoz-Descalzo et al., 2003) germ-band shortening non-traceable author statement (Munoz-Descalzo et al., 2003) JNK cascade non-traceable author statement (Munoz-Descalzo et al., 2004) positive regulation of transcription, DNA-dependent inferred from sequence or structural similarity with Saccharomyces ACE2 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cbt allele Gene References cbtEP2237 pnr (Pena-Rangel et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59480 DroID - A comprehensive database of gene and protein interactions. • FBgn0043364 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33224
Orthologs
Genome-wide drosophilid orthologs	Dana\cbt Dere\cbt Dgri\cbt Dmoj\cbt Dper\cbt Dpse\cbt Dsec\cbt Dsim\cbt Dvir\cbt Dwil\cbt Dyak\cbt
Curated drosophilid orthologs	Dafs\cbt (Munoz-Descalzo et al., 2007) Dana\cbt (Munoz-Descalzo et al., 2007) Dazt\cbt (Munoz-Descalzo et al., 2007) Dere\cbt (Munoz-Descalzo et al., 2007) Dgri\cbt (Munoz-Descalzo et al., 2007) Dmoj\cbt (Munoz-Descalzo et al., 2007) Dper\cbt (Munoz-Descalzo et al., 2007) Dpse\cbt   Dsec\cbt (Munoz-Descalzo et al., 2007) Dsim\cbt (Munoz-Descalzo et al., 2007) Dvir\cbt (Munoz-Descalzo et al., 2007) Dwil\cbt (Munoz-Descalzo et al., 2007) Dyak\cbt (Munoz-Descalzo et al., 2007)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006609-PA Aedes aegypti (mosquito) AGAP009889-PA Anopheles gambiae (mosquito) XP_393807.2 Apis mellifera (honey bee) 27309 Batrachochytrium dendrobatidis (chytrid fungus) 125024 Branchiostoma floridae (lancelet) BGIBMGA006120-PA Bombyx mori (silk worm) CN00714 Caenorhabditis brenneri (small nematode) CE30572 Caenorhabditis elegans (worm) ENSCINP00000012549 Ciona intestinalis (sea squirt) CPIJ015908 Culex pipens (mosquito) ENSCPOP00000014365 Cavia porcellus (guinea pig) RP20724 Caenorhabditis remanei (nematode) ENSDARP00000022792 Danio rerio (zebra fish) ENSECAP00000011139 Equus caballus (horse) ENSGACP00000001933 Gymnopilus aculeatus (mushroom) ENSGALP00000025831 Gallus gallus (chicken) ENSP00000344057 Homo sapiens (human) ENSMODP00000036483 Monodelphis domestica (gray opossum) ENSMMUP00000002748 Macaca mulatta (rhesus monkey) ENSOANP00000012406 Ornithorynchus anatinus (platypus) ENSORLP00000022671 Oryzias latipes (japanese killifish) PP04049 Pristionchus pacificus (nematode) ENSPPYP00000014132 Pongo pygmaeus (orangutan) ENSPTRP00000020024 Pan troglodytes (chimpanzee) XP_971397.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005062 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020527 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015295 Xenopus tropicalis (frog) YALI0C12364g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12517 NV23733 LH19421 ISCW022767 FBgn0233632 FBgn0226609 FBgn0206865 FBgn0194348 FBgn0171577 JGI_V11_44112 FBgn0078183 FBgn0156858 FBgn0140770 FBgn0117994 FBgn0116778 FBgn0101744 CPIJ015908 BGIBMGA006120 GB10114 AGAP009889 AAEL006609 PHUM248360 GLEAN_14124
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Harvard	- PBac{PB}cbtc01139
Kyoto	104895 y* w*; P{GawB}cbtNP5201 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v15555 w1118; P{GD5044}v15555
Genomic Clones ( 2 )
	BACR16A12 BACR48E08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 51 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE07124 SD05726
Other clones	FI01126 SD06353
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP09052 RE25220 RE34593 RE35477 RE50412 RE59057 RE59312 RH01843 RH06419 RH06662 RH07552 RH08615 RH08688 RH23217 RH24071 RH29037 RH50486 RH55484 RH56474 RH72439 SD05727
Other clones	80853 Dmel_dig_003740_0593_2388 Dmel_neb_014874_0932_1984 EC39178 EK032103 EK053237 EK146615 EK169928 EK183935 EK184530 EK218928 EN15240 EP19609 ESG013c.E21_G10 ESG015d.E21.1_A04 ESG0116c.B21_C06 FGM206E06 FGM307C05 IP11659 IP11959 RH69907 RP003021471 RP003152448 RP003308593 RP003388182 RP003455285
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0043364 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33224
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: cabut EP2237 (Munoz, 2004.2.25)
Source for database merge of	Source for merge of: EP2237 CG4427 (Kraut et al., 2001)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation. (Guertin et al., 2006) Molecular and genetic analyses show that cbt expression is dependent on the JNK cascade during dorsal closure, and functions downstream of Jra to regulate dpp expression in the leading edge cells. (Munoz-Descalzo et al., 2005) cbt is essential for dorsal closure. (Munoz-Descalzo et al., 2004) Embryos mutant for cbt do not complete embryogenesis and frequently have holes in the dorsal-anterior region of their cuticles. The polarization of the dorsal-most epidermal cells in dorsal closure and also the activation of the JNK cascade at the leading edge cells is affected in cbt mutants. (Munoz-Descalzo et al., 2004) Identification: in a gain-of-function screen for genes involved in the generation of planar cell polarity. (Munoz-Descalzo et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134685 NM_164384 RefSeq (Proteins) • NP_608529 NP_722636 DDBJ / EMBL / GenBank • AAF51489 AAL29150 AAN10498 AI295427 AI533768 AJ749862 AQ254840 AW944434 AY061602 CAG44484 CZ466932 CZ467222 Entrez Gene - A searchable database of RefSeq genes. • 33224 UniProtKB/TrEMBL • Q4R0P9 Q8IPV7 Q9VPQ5 Q95R58
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59480 DroID - A comprehensive database of gene and protein interactions. • FBgn0043364 DRSC - Results from RNAi screens. • FBgn0043364 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043364 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4427-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0043364 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33224 InParanoid A subset of ortholog calls from InParanoid. • AAEL006609-PA Aedes aegypti (mosquito) AGAP009889-PA Anopheles gambiae (mosquito) XP_393807.2 Apis mellifera (honey bee) 27309 Batrachochytrium dendrobatidis (chytrid fungus) 125024 Branchiostoma floridae (lancelet) BGIBMGA006120-PA Bombyx mori (silk worm) CN00714 Caenorhabditis brenneri (small nematode) CE30572 Caenorhabditis elegans (worm) ENSCINP00000012549 Ciona intestinalis (sea squirt) CPIJ015908 Culex pipens (mosquito) ENSCPOP00000014365 Cavia porcellus (guinea pig) RP20724 Caenorhabditis remanei (nematode) ENSDARP00000022792 Danio rerio (zebra fish) ENSECAP00000011139 Equus caballus (horse) ENSGACP00000001933 Gymnopilus aculeatus (mushroom) ENSGALP00000025831 Gallus gallus (chicken) ENSP00000344057 Homo sapiens (human) ENSMODP00000036483 Monodelphis domestica (gray opossum) ENSMMUP00000002748 Macaca mulatta (rhesus monkey) ENSOANP00000012406 Ornithorynchus anatinus (platypus) ENSORLP00000022671 Oryzias latipes (japanese killifish) PP04049 Pristionchus pacificus (nematode) ENSPPYP00000014132 Pongo pygmaeus (orangutan) ENSPTRP00000020024 Pan troglodytes (chimpanzee) XP_971397.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005062 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020527 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015295 Xenopus tropicalis (frog) YALI0C12364g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33224 modMine - Data generated by the modENCODE project. • FBgn0043364 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12517 NV23733 LH19421 ISCW022767 FBgn0233632 FBgn0226609 FBgn0206865 FBgn0194348 FBgn0171577 JGI_V11_44112 FBgn0078183 FBgn0156858 FBgn0140770 FBgn0117994 FBgn0116778 FBgn0101744 CPIJ015908 BGIBMGA006120 GB10114 AGAP009889 AAEL006609 PHUM248360 GLEAN_14124
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Cabot (Brown et al., 2005) cabut (Beckstead et al., 2005) Cabut (Beckstead et al., 2005) cbt (Khokhar et al., 2008, Blanco et al., 2010, Belacortu et al., 2007, Zhao et al., 2008, Truscott et al., 2011, Munoz-Descalzo et al., 2007, Isogai et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Lee et al., 2008, Ida et al., 2009, Dworkin et al., 2009, Fujikawa et al., 2009, Bushati et al., 2008, Nagoshi et al., 2010, Wasbrough et al., 2010) CG4427 (Munoz-Descalzo et al., 2005, Lim et al., 2004, Munoz, 2004.2.25, Rodriguez and Guerrero, 2005, Brown et al., 2005, Guertin et al., 2006, Molnar et al., 2006, Ida et al., 2009, Fujikawa et al., 2009) dTIEG (Rodriguez and Guerrero, 2005) EP2237 (Zinke et al., 2002, Kraut et al., 2001, Kraut et al., 2001, Zou et al., 2000, Abdelilah-Seyfried et al., 2000, Gorski et al., 2003, Kadener et al., 2007, Chen et al., 2008, Birch-Machin et al., 2005, Yatsu et al., 2008) EP(2)2237 (Pena-Rangel et al., 2002)
Name Synonym	cabot (Brown et al., 2005) cabut (Belacortu et al., 2007, Zhao et al., 2008, Molnar et al., 2006, Bejarano et al., 2008, Lebo et al., 2009, Bülow et al., 2010, Morozova et al., 2006) TGF-beta-inducible early gene (Rodriguez and Guerrero, 2005)
Secondary FlyBase IDs
	FBgn0031259
References ( 59 )
Generate a list of	All references relating to this gene ( 59 )
List References by type	Research paper  ( 34 ) Supplementary material  ( 9 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 6 )
	Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Rodriguez, 2011, PLoS ONE 6(4): e18418 Drosophila TIEG Is a Modulator of Different Signalling Pathways Involved in Wing Patterning and Cell Proliferation. [FBrf0213463] Truscott et al., 2011, Genes Dev. 25(17): 1820--1834 mir-11 limits the proapoptotic function of its host gene, dE2f1. [FBrf0215211] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Bülow et al., 2010, PLoS ONE 5(12): e15171 The Drosophila FoxA Ortholog Fork Head Regulates Growth and Gene Expression Downstream of Target of Rapamycin. [FBrf0212705] Nagoshi et al., 2010, Nat. Neurosci. 13(1): 60--68 Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. [FBrf0209632] Show all research papers ...