AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.42
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cbt using the Feature Mapper tool.
cbt protein is nuclear and is first detected in the germ plasm and pole cells of syncytial embryos, and subsequently, in blastoderm stages and during gastrulation. During germband retraction and dorsal closure it is localized in the yolk cell nuclei, lateral epidermis, and the gut primordium/hindgut. It is also present in the amnioserosa at these stages, despite the mRNA not being detected in this tissue.
GBrowse - Visual display of RNA-Seq signalsView Dmel\cbt in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation.
Embryos mutant for cbt do not complete embryogenesis and frequently have holes in the dorsal-anterior region of their cuticles. The polarization of the dorsal-most epidermal cells in dorsal closure and also the activation of the JNK cascade at the leading edge cells is affected in cbt mutants.
Identification: in a gain-of-function screen for genes involved in the generation of planar cell polarity.