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Gene Dmel\CG5986

General Information
Symbol	Dmel\CG5986	Species	D. melanogaster
Name		Annotation symbol	CG5986
Feature type	protein_coding_gene	FlyBase ID	FBgn0043455
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95D10-95D10	Sequence location	3R:19,873,512..19,874,890 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5986 (FBgn0043455). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsocentral bristle; scutellar bristle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Sde2 N-terminal domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624613_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5986. Gene sequence location is 3R:19873512..19874890.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95D10-95D10   Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
Experimentally Determined Cytological Location
Cytogenetic map Notes References 95D5-95D6   (determined by in situ hybridisation)   (Abdelilah-Seyfried et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5986 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5986-RA FBtr0084535  NM_142950   1321   232 CG5986-RB FBtr0321261  NM_001275970   813   232
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5986-PA   FBpp0083920   26.3   232   8.30     NP_651207   AAF56226 CG5986-PB   FBpp0302813   26.3   232   8.30     NP_001262899   AGB96279
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sde2 N-terminal domain (IPR024974)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202849   AE014297 AAF56226   AE014297 AGB96279   AI260170   AI512703   AQ073927   AW942040   AY069317 AAL39462   AZ300972   BI243157   BI353142   BI373693   BI481658   BP549759   CO191617   EV576635   EV577001   EV577186
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCE2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    195.4 Larval Midgut    64.6 Larval Hindgut    91.2 Larval Malpighian Tubules    173.2 Larval Fat Body    133.2 Larval Salivary Gland    144.9 Larval Trachea    162.15 Larval Carcass    100.3 Adult Head    115.1 Adult Eye    166.1 Adult Brain    152.8 Adult Thoracic-Abdominal Ganglion    144.9 Adult Crop    135.5 Adult Midgut    91.1 Adult Hindgut    131 Adult Malpighian Tubules    185.1 Adult Fat Body    118.8 Adult Salivary Gland    122.3 Adult Heart    155.55 Adult VirginFemale Spermatheca    141.5 Adult InseminatedFemale Spermatheca    138 Adult Ovary    278.4 Adult Testis    87.1 Adult Male Accessory Gland    134.8 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    195.4 Larval Midgut    64.6 Larval Hindgut    91.2 Larval Malpighian Tubules    173.2 Larval Fat Body    133.2 Larval Salivary Gland    144.9 Larval Trachea    162.15 Larval Carcass    100.3 Adult Head    115.1 Adult Eye    166.1 Adult Brain    152.8 Adult Thoracic-Abdominal Ganglion    144.9 Adult Crop    135.5 Adult Midgut    91.1 Adult Hindgut    131 Adult Malpighian Tubules    185.1 Adult Fat Body    118.8 Adult Salivary Gland    122.3 Adult Heart    155.55 Adult VirginFemale Spermatheca    141.5 Adult InseminatedFemale Spermatheca    138 Adult Ovary    278.4 Adult Testis    87.1 Adult Male Accessory Gland    134.8 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    195.4 Larval Midgut    64.6 Larval Hindgut    91.2 Larval Malpighian Tubules    173.2 Larval Fat Body    133.2 Larval Salivary Gland    144.9 Larval Trachea    162.15 Larval Carcass    100.3 Adult Head    115.1 Adult Eye    166.1 Adult Brain    152.8 Adult Thoracic-Abdominal Ganglion    144.9 Adult Crop    135.5 Adult Midgut    91.1 Adult Hindgut    131 Adult Malpighian Tubules    185.1 Adult Fat Body    118.8 Adult Salivary Gland    122.3 Adult Heart    155.55 Adult VirginFemale Spermatheca    141.5 Adult InseminatedFemale Spermatheca    138 Adult Ovary    278.4 Adult Testis    87.1 Adult Male Accessory Gland    134.8 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    195.4 Larval Midgut    64.6 Larval Hindgut    91.2 Larval Malpighian Tubules    173.2 Larval Fat Body    133.2 Larval Salivary Gland    144.9 Larval Trachea    162.15 Larval Carcass    100.3 Adult Head    115.1 Adult Eye    166.1 Adult Brain    152.8 Adult Thoracic-Abdominal Ganglion    144.9 Adult Crop    135.5 Adult Midgut    91.1 Adult Hindgut    131 Adult Malpighian Tubules    185.1 Adult Fat Body    118.8 Adult Salivary Gland    122.3 Adult Heart    155.55 Adult VirginFemale Spermatheca    141.5 Adult InseminatedFemale Spermatheca    138 Adult Ovary    278.4 Adult Testis    87.1 Adult Male Accessory Gland    134.8 Adult Carcass    108.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    195.4 Larval Midgut    64.6 Larval Hindgut    91.2 Larval Malpighian Tubules    173.2 Larval Fat Body    133.2 Larval Salivary Gland    144.9 Larval Trachea    162.15 Larval Carcass    100.3 Adult Head    115.1 Adult Eye    166.1 Adult Brain    152.8 Adult Thoracic-Abdominal Ganglion    144.9 Adult Crop    135.5 Adult Midgut    91.1 Adult Hindgut    131 Adult Malpighian Tubules    185.1 Adult Fat Body    118.8 Adult Salivary Gland    122.3 Adult Heart    155.55 Adult VirginFemale Spermatheca    141.5 Adult InseminatedFemale Spermatheca    138 Adult Ovary    278.4 Adult Testis    87.1 Adult Male Accessory Gland    134.8 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    195.4 Larval Midgut    64.6 Larval Hindgut    91.2 Larval Malpighian Tubules    173.2 Larval Fat Body    133.2 Larval Salivary Gland    144.9 Larval Trachea    162.15 Larval Carcass    100.3 Adult Head    115.1 Adult Eye    166.1 Adult Brain    152.8 Adult Thoracic-Abdominal Ganglion    144.9 Adult Crop    135.5 Adult Midgut    91.1 Adult Hindgut    131 Adult Malpighian Tubules    185.1 Adult Fat Body    118.8 Adult Salivary Gland    122.3 Adult Heart    155.55 Adult VirginFemale Spermatheca    141.5 Adult InseminatedFemale Spermatheca    138 Adult Ovary    278.4 Adult Testis    87.1 Adult Male Accessory Gland    134.8 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    195.4 Larval Midgut    64.6 Larval Hindgut    91.2 Larval Malpighian Tubules    173.2 Larval Fat Body    133.2 Larval Salivary Gland    144.9 Larval Trachea    162.15 Larval Carcass    100.3 Adult Head    115.1 Adult Eye    166.1 Adult Brain    152.8 Adult Thoracic-Abdominal Ganglion    144.9 Adult Crop    135.5 Adult Midgut    91.1 Adult Hindgut    131 Adult Malpighian Tubules    185.1 Adult Fat Body    118.8 Adult Salivary Gland    122.3 Adult Heart    155.55 Adult VirginFemale Spermatheca    141.5 Adult InseminatedFemale Spermatheca    138 Adult Ovary    278.4 Adult Testis    87.1 Adult Male Accessory Gland    134.8 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    195.4 Larval Midgut    64.6 Larval Hindgut    91.2 Larval Malpighian Tubules    173.2 Larval Fat Body    133.2 Larval Salivary Gland    144.9 Larval Trachea    162.15 Larval Carcass    100.3 Adult Head    115.1 Adult Eye    166.1 Adult Brain    152.8 Adult Thoracic-Abdominal Ganglion    144.9 Adult Crop    135.5 Adult Midgut    91.1 Adult Hindgut    131 Adult Malpighian Tubules    185.1 Adult Fat Body    118.8 Adult Salivary Gland    122.3 Adult Heart    155.55 Adult VirginFemale Spermatheca    141.5 Adult InseminatedFemale Spermatheca    138 Adult Ovary    278.4 Adult Testis    87.1 Adult Male Accessory Gland    134.8 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    115.1   NA  Eye    166.1   NA  Brain    152.8   195.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    144.9   NA  Crop    135.5   64.6  Midgut    91.1   91.2  Hindgut    131   173.2  Malpighian Tubules    185.1   133.2  Fat Body    118.8   144.9  Salivary Gland    122.3   NA  Heart    155.55   162.15  Trachea    NA   NA  VirginFemale Spermatheca    141.5   NA  InseminatedFemale Spermatheca    138   NA  Ovary    278.4   NA  Testis    87.1   NA  Male Accessory Gland    134.8   100.3  Carcass    108.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    43 central nervous system, pupae P8    19 head, virgin 1-day female    13 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    9 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    24 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    37 carcass, larvae L3 wandering    31 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    14 ovary, virgin 4-day female    55 ovary, mated 4-day female    68 testis, mated 4-day male    19 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (31) central nervous system, larvae L3  (43) central nervous system, pupae P8    19 head, virgin 1-day female    13 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    9 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    24 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae  (63) digestive system, larvae L3 wandering  (31) digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8  (37) carcass, larvae L3 wandering  (31) carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    14 ovary, virgin 4-day female  (55) ovary, mated 4-day female  (68) testis, mated 4-day male    19 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    43 central nervous system, pupae P8    19 head, virgin 1-day female    13 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    9 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    24 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    37 carcass, larvae L3 wandering    31 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    14 ovary, virgin 4-day female    55 ovary, mated 4-day female    68 testis, mated 4-day male    19 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    43 central nervous system, pupae P8    19 head, virgin 1-day female    13 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    9 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    24 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    37 carcass, larvae L3 wandering    31 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    14 ovary, virgin 4-day female    55 ovary, mated 4-day female    68 testis, mated 4-day male    19 accessory gland, mated 4-day male    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    43 central nervous system, pupae P8    19 head, virgin 1-day female    13 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    9 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    24 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    37 carcass, larvae L3 wandering    31 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    14 ovary, virgin 4-day female    55 ovary, mated 4-day female    68 testis, mated 4-day male    19 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  31 central nervous system, larvae L3  (43) central nervous system, pupae P8    19 head, virgin 1-day female    13 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    9 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    24 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae  (63) digestive system, larvae L3 wandering  31 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8  (37) carcass, larvae L3 wandering  31 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    14 ovary, virgin 4-day female  (55) ovary, mated 4-day female  (68) testis, mated 4-day male    19 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    43 central nervous system, pupae P8    19 head, virgin 1-day female    13 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    9 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    24 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    37 carcass, larvae L3 wandering    31 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    14 ovary, virgin 4-day female    55 ovary, mated 4-day female    68 testis, mated 4-day male    19 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    43 central nervous system, pupae P8    19 head, virgin 1-day female    13 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    9 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    24 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    37 carcass, larvae L3 wandering    31 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    14 ovary, virgin 4-day female    55 ovary, mated 4-day female    68 testis, mated 4-day male    19 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    78 embryo 04-06hr    64 embryo 06-08hr    49 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    16 embryo 20-22hr    20 embryo 22-24hr    19 larva L1    11 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    23 white prepupae new    27 white prepupae 12hr    22 white prepupae 24hr    22 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    18 adult male 05day    16 adult male 30day    9 adult female 01day    14 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (54) embryo 02-04hr  (78) embryo 04-06hr  (64) embryo 06-08hr  (49) embryo 08-10hr  (44) embryo 10-12hr  (37) embryo 12-14hr  (33) embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    16 embryo 20-22hr    20 embryo 22-24hr    19 larva L1    11 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    23 white prepupae new  (27) white prepupae 12hr    22 white prepupae 24hr    22 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    18 adult male 05day    16 adult male 30day    9 adult female 01day    14 adult female 05day  (34) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    78 embryo 04-06hr    64 embryo 06-08hr    49 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    16 embryo 20-22hr    20 embryo 22-24hr    19 larva L1    11 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    23 white prepupae new    27 white prepupae 12hr    22 white prepupae 24hr    22 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    18 adult male 05day    16 adult male 30day    9 adult female 01day    14 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    78 embryo 04-06hr    64 embryo 06-08hr    49 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    16 embryo 20-22hr    20 embryo 22-24hr    19 larva L1    11 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    23 white prepupae new    27 white prepupae 12hr    22 white prepupae 24hr    22 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    18 adult male 05day    16 adult male 30day    9 adult female 01day    14 adult female 05day    34 adult female 30day    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    78 embryo 04-06hr    64 embryo 06-08hr    49 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    16 embryo 20-22hr    20 embryo 22-24hr    19 larva L1    11 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    23 white prepupae new    27 white prepupae 12hr    22 white prepupae 24hr    22 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    18 adult male 05day    16 adult male 30day    9 adult female 01day    14 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (54) embryo 02-04hr  (78) embryo 04-06hr  (64) embryo 06-08hr  (49) embryo 08-10hr  (44) embryo 10-12hr  (37) embryo 12-14hr  (33) embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    16 embryo 20-22hr    20 embryo 22-24hr    19 larva L1    11 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    23 white prepupae new  27 white prepupae 12hr    22 white prepupae 24hr    22 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    18 adult male 05day    16 adult male 30day    9 adult female 01day    14 adult female 05day  (34) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    78 embryo 04-06hr    64 embryo 06-08hr    49 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    16 embryo 20-22hr    20 embryo 22-24hr    19 larva L1    11 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    23 white prepupae new    27 white prepupae 12hr    22 white prepupae 24hr    22 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    18 adult male 05day    16 adult male 30day    9 adult female 01day    14 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    78 embryo 04-06hr    64 embryo 06-08hr    49 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    16 embryo 20-22hr    20 embryo 22-24hr    19 larva L1    11 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    23 white prepupae new    27 white prepupae 12hr    22 white prepupae 24hr    22 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    18 adult male 05day    16 adult male 30day    9 adult female 01day    14 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    23 embryonic 1182-4H    46 embryonic GM2    45 embryonic Kc167    43 embryonic S1    52 embryonic S3    32 leg disc CME L1    39 wing disc CME-W2    24 wing disc ML-DmD8    32 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    36 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    37 ovary fGS/OSS    92 ovary OSC    60 ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (91) Schneider line 2 Sg4    23 embryonic 1182-4H  (46) embryonic GM2  (45) embryonic Kc167  (43) embryonic S1  (52) embryonic S3  (32) leg disc CME L1  (39) wing disc CME-W2    24 wing disc ML-DmD8  (32) wing disc ML-DmD9  (42) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (36) wing disc ML-DmD32  (41) haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  (34) antennal disc ML-DmD20-c5  (28) mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1  (54) CNS ML-DmBG2-c2  (39) tumorous blood cells mbn2  (37) ovary fGS/OSS  (92) ovary OSC  (60) ovary OSS  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    23 embryonic 1182-4H    46 embryonic GM2    45 embryonic Kc167    43 embryonic S1    52 embryonic S3    32 leg disc CME L1    39 wing disc CME-W2    24 wing disc ML-DmD8    32 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    36 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    37 ovary fGS/OSS    92 ovary OSC    60 ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    23 embryonic 1182-4H    46 embryonic GM2    45 embryonic Kc167    43 embryonic S1    52 embryonic S3    32 leg disc CME L1    39 wing disc CME-W2    24 wing disc ML-DmD8    32 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    36 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    37 ovary fGS/OSS    92 ovary OSC    60 ovary OSS    52 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    23 embryonic 1182-4H    46 embryonic GM2    45 embryonic Kc167    43 embryonic S1    52 embryonic S3    32 leg disc CME L1    39 wing disc CME-W2    24 wing disc ML-DmD8    32 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    36 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    37 ovary fGS/OSS    92 ovary OSC    60 ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (91) Schneider line 2 Sg4    23 embryonic 1182-4H  (46) embryonic GM2  (45) embryonic Kc167  (43) embryonic S1  (52) embryonic S3  32 leg disc CME L1  (39) wing disc CME-W2    24 wing disc ML-DmD8  32 wing disc ML-DmD9  (42) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (36) wing disc ML-DmD32  (41) haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  (34) antennal disc ML-DmD20-c5  28 mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1  (54) CNS ML-DmBG2-c2  (39) tumorous blood cells mbn2  (37) ovary fGS/OSS  (92) ovary OSC  (60) ovary OSS  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    23 embryonic 1182-4H    46 embryonic GM2    45 embryonic Kc167    43 embryonic S1    52 embryonic S3    32 leg disc CME L1    39 wing disc CME-W2    24 wing disc ML-DmD8    32 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    36 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    37 ovary fGS/OSS    92 ovary OSC    60 ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    23 embryonic 1182-4H    46 embryonic GM2    45 embryonic Kc167    43 embryonic S1    52 embryonic S3    32 leg disc CME L1    39 wing disc CME-W2    24 wing disc ML-DmD8    32 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    36 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    37 ovary fGS/OSS    92 ovary OSC    60 ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    20 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (31) cold shock, 4-day adult    20 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (45) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  (38) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (34) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (41) Caffeine 25 mg/ml 48 hrs, 4-day adult  26 Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  (28) Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    20 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    20 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    20 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  31 cold shock, 4-day adult    20 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (45) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  (38) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (34) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (41) Caffeine 25 mg/ml 48 hrs, 4-day adult  26 Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  28 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    20 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    20 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD03179 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043455 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5986-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG5986GD9900 Other Phenotypes Allele visible, with Scer\GAL4GMR.PF CG5986EP3278 visible, with Scer\GAL4sca-537.4 CG5986EP3278 Phenotype manifest in Allele dorsocentral bristle, with Scer\GAL4sca-537.4 CG5986EP3278 eye, with Scer\GAL4GMR.PF CG5986EP3278 scutellar bristle, with Scer\GAL4sca-537.4 CG5986EP3278
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG5986 Class Mutagen Stocks Known lesion CG5986EY02351 P-element activity 1 Yes CG5986EP3278 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5986 Class Mutagen Stocks Known lesion CG5986GD9900 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG5986KK109185 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5986NIG.5986R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6197 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9900} NA P{KK109185} NA P{NIG.5986R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG5986EP3278 NA P{EP}Rox8EP3338 NA P{EPgy2}Rox8EY02351 NA miscellaneous insertions PBac{RB}Rox8e01157 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG5986 - AnxB10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - CG10638 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - CG14715 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - CG2862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - Eno anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - Sh3β anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - Trx-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - awd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - fabp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - regucalcin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5986 - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5986 allele Gene References unspecified H (Mueller et al., 2005) th (Mueller et al., 2005)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0043455 DroID - A comprehensive database of gene and protein interactions. • FBgn0043455 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 192506
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG65DX8X Dipteran inclusive ortholog search EOG60S0R7 Insect inclusive ortholog search EOG6V4256 Arthropod inclusive ortholog search EOG6XSJ68 Metazoa inclusive ortholog search EOG6Z99QW
Orthologs in Drosophila Species (EOG65DX8X)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG5986     Drosophila simulans   Dsim\GD21057 Y   Drosophila sechellia   Dsec\GM26552 Y   Drosophila erecta   Dere\GG11248 Y   Drosophila yakuba   Dyak\GE23440 Y   Drosophila ananassae   Dana\GF17035 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19277 Y   Drosophila persimilis   Dper\GL23395 Y   Drosophila willistoni   Dwil\GK11149 Y   Drosophila virilis   Dvir\GJ14192 Y   Drosophila mojavensis   Dmoj\GI24631 Y   Drosophila grimshawi   Dgri\GH18485 Y
Orthologs in non-Drosophila Dipterans (EOG60S0R7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013265   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007155   Anopheles gambiae Malaria mosquito  Agam\AGAP001314
Orthologs in non-Dipteran Insects (EOG6V4256)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413477   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003234   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19441   Atta cephalotes Leafcutter ant  Acep\ACEP24631   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16711   Linepithema humile Argentine ant  Lhum\LH23042   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17161   Solenopsis invicta Red fire ant  Sinv\SINV25259   Acyrthosiphon pisum Pea aphid  Apim\ACYPI29680   Bombyx mori Silkmoth  Bmor\BGIBMGA009166   Pediculus humanus Human body louse  Phum\PHUM546560
Orthologs in non-Insect Arthropods (EOG6XSJ68)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_227204   Ixodes scapularis Deer tick  Isca\ISCW021020
Orthologs in non-Arthropod Metazoa (EOG6Z99QW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F53F4.14   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025032gn   Danio rerio Zebrafish  Drer\zgc:112095   Xenopus tropicalis Western clawed frog  Xtro\c1orf55   Gallus gallus Domestic chicken  Ggal\C1orf55   Mus musculus House mouse  Mmus\ENSMUSG00000038806   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000003247   Homo sapiens Human  Hsap\C1orf55
Human Orthologs (1)
Gene OMIM HGNC Hsap\C1orf55
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21057 Drosophila sechellia Dsec\GM26552 Drosophila erecta Dere\GG11248 Drosophila yakuba Dyak\GE23440 Drosophila ananassae Dana\GF17035 Drosophila pseudoobscura pseudoobscura Dpse\GA19277 Drosophila persimilis Dper\GL23395 Drosophila willistoni Dwil\GK11149 Drosophila virilis Dvir\GJ14192 Drosophila mojavensis Dmoj\GI24631 Drosophila grimshawi Dgri\GH18485
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	15865 y1 w67c23; P{EPgy2}Rox8EY02351 CG5986EY02351
VDRC	v101446 P{KK109185}VIE-260B v25480 w1118; P{GD9900}v25480 v25479 w1118; P{GD9900}v25479/TM3
Genomic Clones ( 1 )
	BACR15J11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD03179
Other clones	DPiM_LD03179
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM22455 LD44658 RE40721 RE61064 RE64247
Other clones	Dmel_dig_003736_0690_3159 Dmel_dig_005243_0664_1963 Dmel_dig_018274_0641_1244 EC31530 FGM103C11
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0043455 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 192506
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: BEST:LP03871 CG5986 (FlyBase, 1996-)
Additional comments	Source for merge of BEST:LP03871 CG5986 was shared EST (LP03871) (date:020218). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142950 NM_001275970 RefSeq (Proteins) • NP_651207 NP_001262899 DDBJ / EMBL / GenBank • AA202849 AAF56226 AAL39462 AGB96279 AI260170 AQ073927 AW942040 AY069317 AZ300972 Entrez Gene - A searchable database of RefSeq genes. • 192506 UniProtKB/TrEMBL • Q9VCE2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sde2 N-terminal domain (IPR024974) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD03179
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0043455 DroID - A comprehensive database of gene and protein interactions. • FBgn0043455 DRSC - Results from RNAi screens. • FBgn0043455 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043455 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5986-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0043455 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 192506 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 192506 modMine - Data generated by the modENCODE project. • FBgn0043455
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BEST:LP03871 (Abdelilah-Seyfried et al., 2000, ) CG5986 (Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
	FBgn0039142
References ( 14 )
Research paper	Mueller et al., 2005, Genetics 171(3): 1137--1152 Genetic modifier screens on hairless gain-of function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. [FBrf0190751] Abdelilah-Seyfried et al., 2000, Genetics 155(2): 733--752 A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. [FBrf0128367]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]