General Information Symbol Dmel\ CG4747Species D. melanogaster Name Annotation symbol CG4747 Feature type protein_coding_gene FlyBase ID FBgn0043456 Gene Model Status Current Stock availability 6 publicly
available Also Known As BEST:LD22483 Genomic Location Chromosome (arm) 2L Recombination map Cytogenetic map 30F5-30F5 Sequence location 2L:10,003,825..10,008,889 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information This gene is referred to in FlyBase by the symbol
Dmel\CG4747 (FBgn0043456). It is a protein_coding_gene from
Drosophila melanogaster . Based on sequence similarity, it is predicted to have
molecular function : 3-hydroxyisobutyrate dehydrogenase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the
biological process : pentose-phosphate shunt.
7 alleles are reported . The
phenotypes of these alleles are annotated with: trichogen cell; dorsocentral bristle; tormogen cell; scutellar bristle. It has
2 annotated transcripts and
2 annotated polypeptides .
Protein features are: 6-phosphogluconate dehydrogenase, C-terminal-like; 6-phosphogluconate dehydrogenase, NADP-binding; Dehydrogenase, multihelical; Hydroxy monocarboxylic acid anion dehydrogenase, HIBADH-type; NAD(P)-binding domain; PWWP. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634579_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG4747. Gene sequence location is
2L:10003825..10008889 .
User Contributed Data
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FB2013_03
Alleles
Transgenic Constructs
Controlled Vocabulary Terms
FB2013_02
All updates
Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
30F5-30F6
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
769.1
Larval Midgut
185.5
Larval Hindgut
365.8
Larval Malpighian Tubules
215.9
Larval Fat Body
152.9
Larval Salivary Gland
621.9
Larval Trachea
481.1
Larval Carcass
289.8
Adult Head
173.7
Adult Eye
220.8
Adult Brain
423.2
Adult Thoracic-Abdominal Ganglion
260.7
Adult Crop
253.9
Adult Midgut
205
Adult Hindgut
207
Adult Malpighian Tubules
124.1
Adult Fat Body
217.9
Adult Salivary Gland
188.8
Adult Heart
204.825
Adult VirginFemale Spermatheca
116.6
Adult InseminatedFemale Spermatheca
157.5
Adult Ovary
779.3
Adult Testis
98.5
Adult Male Accessory Gland
360.2
Adult Carcass
146.9
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(769.1)
Larval Midgut
185.5
Larval Hindgut
365.8
Larval Malpighian Tubules
215.9
Larval Fat Body
152.9
Larval Salivary Gland
(621.9)
Larval Trachea
481.1
Larval Carcass
289.8
Adult Head
173.7
Adult Eye
220.8
Adult Brain
423.2
Adult Thoracic-Abdominal Ganglion
260.7
Adult Crop
253.9
Adult Midgut
205
Adult Hindgut
207
Adult Malpighian Tubules
124.1
Adult Fat Body
217.9
Adult Salivary Gland
188.8
Adult Heart
204.825
Adult VirginFemale Spermatheca
116.6
Adult InseminatedFemale Spermatheca
157.5
Adult Ovary
(779.3)
Adult Testis
98.5
Adult Male Accessory Gland
360.2
Adult Carcass
146.9
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
769.1
Larval Midgut
185.5
Larval Hindgut
365.8
Larval Malpighian Tubules
215.9
Larval Fat Body
152.9
Larval Salivary Gland
621.9
Larval Trachea
481.1
Larval Carcass
289.8
Adult Head
173.7
Adult Eye
220.8
Adult Brain
423.2
Adult Thoracic-Abdominal Ganglion
260.7
Adult Crop
253.9
Adult Midgut
205
Adult Hindgut
207
Adult Malpighian Tubules
124.1
Adult Fat Body
217.9
Adult Salivary Gland
188.8
Adult Heart
204.825
Adult VirginFemale Spermatheca
116.6
Adult InseminatedFemale Spermatheca
157.5
Adult Ovary
779.3
Adult Testis
98.5
Adult Male Accessory Gland
360.2
Adult Carcass
146.9
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
769.1
Larval Midgut
185.5
Larval Hindgut
365.8
Larval Malpighian Tubules
215.9
Larval Fat Body
152.9
Larval Salivary Gland
621.9
Larval Trachea
481.1
Larval Carcass
289.8
Adult Head
173.7
Adult Eye
220.8
Adult Brain
423.2
Adult Thoracic-Abdominal Ganglion
260.7
Adult Crop
253.9
Adult Midgut
205
Adult Hindgut
207
Adult Malpighian Tubules
124.1
Adult Fat Body
217.9
Adult Salivary Gland
188.8
Adult Heart
204.825
Adult VirginFemale Spermatheca
116.6
Adult InseminatedFemale Spermatheca
157.5
Adult Ovary
779.3
Adult Testis
98.5
Adult Male Accessory Gland
360.2
Adult Carcass
146.9
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
769.1
Larval Midgut
185.5
Larval Hindgut
365.8
Larval Malpighian Tubules
215.9
Larval Fat Body
152.9
Larval Salivary Gland
621.9
Larval Trachea
481.1
Larval Carcass
289.8
Adult Head
173.7
Adult Eye
220.8
Adult Brain
423.2
Adult Thoracic-Abdominal Ganglion
260.7
Adult Crop
253.9
Adult Midgut
205
Adult Hindgut
207
Adult Malpighian Tubules
124.1
Adult Fat Body
217.9
Adult Salivary Gland
188.8
Adult Heart
204.825
Adult VirginFemale Spermatheca
116.6
Adult InseminatedFemale Spermatheca
157.5
Adult Ovary
779.3
Adult Testis
98.5
Adult Male Accessory Gland
360.2
Adult Carcass
146.9
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
769.1
Larval Midgut
185.5
Larval Hindgut
365.8
Larval Malpighian Tubules
215.9
Larval Fat Body
152.9
Larval Salivary Gland
621.9
Larval Trachea
481.1
Larval Carcass
289.8
Adult Head
173.7
Adult Eye
220.8
Adult Brain
423.2
Adult Thoracic-Abdominal Ganglion
260.7
Adult Crop
253.9
Adult Midgut
205
Adult Hindgut
207
Adult Malpighian Tubules
124.1
Adult Fat Body
217.9
Adult Salivary Gland
188.8
Adult Heart
204.825
Adult VirginFemale Spermatheca
116.6
Adult InseminatedFemale Spermatheca
157.5
Adult Ovary
779.3
Adult Testis
98.5
Adult Male Accessory Gland
360.2
Adult Carcass
146.9
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
769.1
Larval Midgut
185.5
Larval Hindgut
365.8
Larval Malpighian Tubules
215.9
Larval Fat Body
152.9
Larval Salivary Gland
621.9
Larval Trachea
481.1
Larval Carcass
289.8
Adult Head
173.7
Adult Eye
220.8
Adult Brain
423.2
Adult Thoracic-Abdominal Ganglion
260.7
Adult Crop
253.9
Adult Midgut
205
Adult Hindgut
207
Adult Malpighian Tubules
124.1
Adult Fat Body
217.9
Adult Salivary Gland
188.8
Adult Heart
204.825
Adult VirginFemale Spermatheca
116.6
Adult InseminatedFemale Spermatheca
157.5
Adult Ovary
779.3
Adult Testis
98.5
Adult Male Accessory Gland
360.2
Adult Carcass
146.9
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
769.1
Larval Midgut
185.5
Larval Hindgut
365.8
Larval Malpighian Tubules
215.9
Larval Fat Body
152.9
Larval Salivary Gland
621.9
Larval Trachea
481.1
Larval Carcass
289.8
Adult Head
173.7
Adult Eye
220.8
Adult Brain
423.2
Adult Thoracic-Abdominal Ganglion
260.7
Adult Crop
253.9
Adult Midgut
205
Adult Hindgut
207
Adult Malpighian Tubules
124.1
Adult Fat Body
217.9
Adult Salivary Gland
188.8
Adult Heart
204.825
Adult VirginFemale Spermatheca
116.6
Adult InseminatedFemale Spermatheca
157.5
Adult Ovary
779.3
Adult Testis
98.5
Adult Male Accessory Gland
360.2
Adult Carcass
146.9
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
173.7
NA
Eye
220.8
NA
Brain
423.2
769.1
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
260.7
NA
Crop
253.9
185.5
Midgut
205
365.8
Hindgut
207
215.9
Malpighian Tubules
124.1
152.9
Fat Body
217.9
621.9
Salivary Gland
188.8
NA
Heart
204.825
481.1
Trachea
NA
NA
VirginFemale Spermatheca
116.6
NA
InseminatedFemale Spermatheca
157.5
NA
Ovary
779.3
NA
Testis
98.5
NA
Male Accessory Gland
360.2
289.8
Carcass
146.9
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
171
central nervous system, larvae L3
253
central nervous system, pupae P8
88
head, virgin 1-day female
59
head, virgin 4-day female
63
head, virgin 20-day female
39
head, mated 1-day female
58
head, mated 4-day female
58
head, mated 20-day female
43
head, mated 1-day male
59
head, mated 4-day male
76
head, mated 20-day male
85
salivary gland, larvae L3 wandering
29
salivary gland, white prepupae
54
digestive system, larvae L3 wandering
56
digestive system, 1-day adult
40
digestive system, 4-day adult
64
digestive system, 20-day adult
48
fat body, larvae L3 wandering
33
fat body, white prepupae
67
fat body, pupae P8
81
carcass, larvae L3 wandering
148
carcass, 1-day adult
41
carcass, 4-day adult
65
carcass, 20-day adult
50
ovary, virgin 4-day female
294
ovary, mated 4-day female
312
testis, mated 4-day male
41
accessory gland, mated 4-day male
47
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(171)
central nervous system, larvae L3
(253)
central nervous system, pupae P8
(88)
head, virgin 1-day female
(59)
head, virgin 4-day female
(63)
head, virgin 20-day female
(39)
head, mated 1-day female
(58)
head, mated 4-day female
(58)
head, mated 20-day female
(43)
head, mated 1-day male
(59)
head, mated 4-day male
(76)
head, mated 20-day male
(85)
salivary gland, larvae L3 wandering
(29)
salivary gland, white prepupae
(54)
digestive system, larvae L3 wandering
(56)
digestive system, 1-day adult
(40)
digestive system, 4-day adult
(64)
digestive system, 20-day adult
(48)
fat body, larvae L3 wandering
(33)
fat body, white prepupae
(67)
fat body, pupae P8
(81)
carcass, larvae L3 wandering
(148)
carcass, 1-day adult
(41)
carcass, 4-day adult
(65)
carcass, 20-day adult
(50)
ovary, virgin 4-day female
(294)
ovary, mated 4-day female
(312)
testis, mated 4-day male
(41)
accessory gland, mated 4-day male
(47)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(171)
central nervous system, larvae L3
(253)
central nervous system, pupae P8
88
head, virgin 1-day female
59
head, virgin 4-day female
63
head, virgin 20-day female
39
head, mated 1-day female
58
head, mated 4-day female
58
head, mated 20-day female
43
head, mated 1-day male
59
head, mated 4-day male
76
head, mated 20-day male
85
salivary gland, larvae L3 wandering
29
salivary gland, white prepupae
54
digestive system, larvae L3 wandering
56
digestive system, 1-day adult
40
digestive system, 4-day adult
64
digestive system, 20-day adult
48
fat body, larvae L3 wandering
33
fat body, white prepupae
67
fat body, pupae P8
81
carcass, larvae L3 wandering
(148)
carcass, 1-day adult
41
carcass, 4-day adult
65
carcass, 20-day adult
50
ovary, virgin 4-day female
(294)
ovary, mated 4-day female
(312)
testis, mated 4-day male
41
accessory gland, mated 4-day male
47
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
171
central nervous system, larvae L3
253
central nervous system, pupae P8
88
head, virgin 1-day female
59
head, virgin 4-day female
63
head, virgin 20-day female
39
head, mated 1-day female
58
head, mated 4-day female
58
head, mated 20-day female
43
head, mated 1-day male
59
head, mated 4-day male
76
head, mated 20-day male
85
salivary gland, larvae L3 wandering
29
salivary gland, white prepupae
54
digestive system, larvae L3 wandering
56
digestive system, 1-day adult
40
digestive system, 4-day adult
64
digestive system, 20-day adult
48
fat body, larvae L3 wandering
33
fat body, white prepupae
67
fat body, pupae P8
81
carcass, larvae L3 wandering
148
carcass, 1-day adult
41
carcass, 4-day adult
65
carcass, 20-day adult
50
ovary, virgin 4-day female
294
ovary, mated 4-day female
312
testis, mated 4-day male
41
accessory gland, mated 4-day male
47
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
171
central nervous system, larvae L3
253
central nervous system, pupae P8
88
head, virgin 1-day female
59
head, virgin 4-day female
63
head, virgin 20-day female
39
head, mated 1-day female
58
head, mated 4-day female
58
head, mated 20-day female
43
head, mated 1-day male
59
head, mated 4-day male
76
head, mated 20-day male
85
salivary gland, larvae L3 wandering
29
salivary gland, white prepupae
54
digestive system, larvae L3 wandering
56
digestive system, 1-day adult
40
digestive system, 4-day adult
64
digestive system, 20-day adult
48
fat body, larvae L3 wandering
33
fat body, white prepupae
67
fat body, pupae P8
81
carcass, larvae L3 wandering
148
carcass, 1-day adult
41
carcass, 4-day adult
65
carcass, 20-day adult
50
ovary, virgin 4-day female
294
ovary, mated 4-day female
312
testis, mated 4-day male
41
accessory gland, mated 4-day male
47
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(171)
central nervous system, larvae L3
(253)
central nervous system, pupae P8
(88)
head, virgin 1-day female
(59)
head, virgin 4-day female
(63)
head, virgin 20-day female
(39)
head, mated 1-day female
(58)
head, mated 4-day female
(58)
head, mated 20-day female
(43)
head, mated 1-day male
(59)
head, mated 4-day male
(76)
head, mated 20-day male
(85)
salivary gland, larvae L3 wandering
29
salivary gland, white prepupae
(54)
digestive system, larvae L3 wandering
(56)
digestive system, 1-day adult
(40)
digestive system, 4-day adult
(64)
digestive system, 20-day adult
(48)
fat body, larvae L3 wandering
(33)
fat body, white prepupae
(67)
fat body, pupae P8
(81)
carcass, larvae L3 wandering
(148)
carcass, 1-day adult
(41)
carcass, 4-day adult
(65)
carcass, 20-day adult
(50)
ovary, virgin 4-day female
(294)
ovary, mated 4-day female
(312)
testis, mated 4-day male
(41)
accessory gland, mated 4-day male
(47)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(171)
central nervous system, larvae L3
(253)
central nervous system, pupae P8
88
head, virgin 1-day female
59
head, virgin 4-day female
63
head, virgin 20-day female
39
head, mated 1-day female
58
head, mated 4-day female
58
head, mated 20-day female
43
head, mated 1-day male
59
head, mated 4-day male
76
head, mated 20-day male
85
salivary gland, larvae L3 wandering
29
salivary gland, white prepupae
54
digestive system, larvae L3 wandering
56
digestive system, 1-day adult
40
digestive system, 4-day adult
64
digestive system, 20-day adult
48
fat body, larvae L3 wandering
33
fat body, white prepupae
67
fat body, pupae P8
81
carcass, larvae L3 wandering
(148)
carcass, 1-day adult
41
carcass, 4-day adult
65
carcass, 20-day adult
50
ovary, virgin 4-day female
(294)
ovary, mated 4-day female
(312)
testis, mated 4-day male
41
accessory gland, mated 4-day male
47
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
171
central nervous system, larvae L3
253
central nervous system, pupae P8
88
head, virgin 1-day female
59
head, virgin 4-day female
63
head, virgin 20-day female
39
head, mated 1-day female
58
head, mated 4-day female
58
head, mated 20-day female
43
head, mated 1-day male
59
head, mated 4-day male
76
head, mated 20-day male
85
salivary gland, larvae L3 wandering
29
salivary gland, white prepupae
54
digestive system, larvae L3 wandering
56
digestive system, 1-day adult
40
digestive system, 4-day adult
64
digestive system, 20-day adult
48
fat body, larvae L3 wandering
33
fat body, white prepupae
67
fat body, pupae P8
81
carcass, larvae L3 wandering
148
carcass, 1-day adult
41
carcass, 4-day adult
65
carcass, 20-day adult
50
ovary, virgin 4-day female
294
ovary, mated 4-day female
312
testis, mated 4-day male
41
accessory gland, mated 4-day male
47
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
169
embryo 02-04hr
242
embryo 04-06hr
295
embryo 06-08hr
382
embryo 08-10hr
279
embryo 10-12hr
181
embryo 12-14hr
152
embryo 14-16hr
102
embryo 16-18hr
77
embryo 18-20hr
42
embryo 20-22hr
51
embryo 22-24hr
54
larva L1
62
larva L2
65
larva L3 12hr old
41
larva L3 puffstage 1-2
35
larva L3 puffstage 3-6
56
larva L3 puffstage 7-9
67
white prepupae new
64
white prepupae 12hr
59
white prepupae 24hr
73
pupae 2d postWPP
38
pupae 3d postWPP
23
pupae 4d postWPP
20
adult male 01day
24
adult male 05day
24
adult male 30day
23
adult female 01day
59
adult female 05day
95
adult female 30day
91
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(169)
embryo 02-04hr
(242)
embryo 04-06hr
(295)
embryo 06-08hr
(382)
embryo 08-10hr
(279)
embryo 10-12hr
(181)
embryo 12-14hr
(152)
embryo 14-16hr
(102)
embryo 16-18hr
(77)
embryo 18-20hr
(42)
embryo 20-22hr
(51)
embryo 22-24hr
(54)
larva L1
(62)
larva L2
(65)
larva L3 12hr old
(41)
larva L3 puffstage 1-2
(35)
larva L3 puffstage 3-6
(56)
larva L3 puffstage 7-9
(67)
white prepupae new
(64)
white prepupae 12hr
(59)
white prepupae 24hr
(73)
pupae 2d postWPP
(38)
pupae 3d postWPP
23
pupae 4d postWPP
20
adult male 01day
24
adult male 05day
24
adult male 30day
23
adult female 01day
(59)
adult female 05day
(95)
adult female 30day
(91)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
(169)
embryo 02-04hr
(242)
embryo 04-06hr
(295)
embryo 06-08hr
(382)
embryo 08-10hr
(279)
embryo 10-12hr
(181)
embryo 12-14hr
(152)
embryo 14-16hr
102
embryo 16-18hr
77
embryo 18-20hr
42
embryo 20-22hr
51
embryo 22-24hr
54
larva L1
62
larva L2
65
larva L3 12hr old
41
larva L3 puffstage 1-2
35
larva L3 puffstage 3-6
56
larva L3 puffstage 7-9
67
white prepupae new
64
white prepupae 12hr
59
white prepupae 24hr
73
pupae 2d postWPP
38
pupae 3d postWPP
23
pupae 4d postWPP
20
adult male 01day
24
adult male 05day
24
adult male 30day
23
adult female 01day
59
adult female 05day
95
adult female 30day
91
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
169
embryo 02-04hr
242
embryo 04-06hr
295
embryo 06-08hr
382
embryo 08-10hr
279
embryo 10-12hr
181
embryo 12-14hr
152
embryo 14-16hr
102
embryo 16-18hr
77
embryo 18-20hr
42
embryo 20-22hr
51
embryo 22-24hr
54
larva L1
62
larva L2
65
larva L3 12hr old
41
larva L3 puffstage 1-2
35
larva L3 puffstage 3-6
56
larva L3 puffstage 7-9
67
white prepupae new
64
white prepupae 12hr
59
white prepupae 24hr
73
pupae 2d postWPP
38
pupae 3d postWPP
23
pupae 4d postWPP
20
adult male 01day
24
adult male 05day
24
adult male 30day
23
adult female 01day
59
adult female 05day
95
adult female 30day
91
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
169
embryo 02-04hr
242
embryo 04-06hr
295
embryo 06-08hr
382
embryo 08-10hr
279
embryo 10-12hr
181
embryo 12-14hr
152
embryo 14-16hr
102
embryo 16-18hr
77
embryo 18-20hr
42
embryo 20-22hr
51
embryo 22-24hr
54
larva L1
62
larva L2
65
larva L3 12hr old
41
larva L3 puffstage 1-2
35
larva L3 puffstage 3-6
56
larva L3 puffstage 7-9
67
white prepupae new
64
white prepupae 12hr
59
white prepupae 24hr
73
pupae 2d postWPP
38
pupae 3d postWPP
23
pupae 4d postWPP
20
adult male 01day
24
adult male 05day
24
adult male 30day
23
adult female 01day
59
adult female 05day
95
adult female 30day
91
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(169)
embryo 02-04hr
(242)
embryo 04-06hr
(295)
embryo 06-08hr
(382)
embryo 08-10hr
(279)
embryo 10-12hr
(181)
embryo 12-14hr
(152)
embryo 14-16hr
(102)
embryo 16-18hr
(77)
embryo 18-20hr
(42)
embryo 20-22hr
(51)
embryo 22-24hr
(54)
larva L1
(62)
larva L2
(65)
larva L3 12hr old
(41)
larva L3 puffstage 1-2
(35)
larva L3 puffstage 3-6
(56)
larva L3 puffstage 7-9
(67)
white prepupae new
(64)
white prepupae 12hr
(59)
white prepupae 24hr
(73)
pupae 2d postWPP
(38)
pupae 3d postWPP
23
pupae 4d postWPP
20
adult male 01day
24
adult male 05day
24
adult male 30day
23
adult female 01day
(59)
adult female 05day
(95)
adult female 30day
(91)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
(169)
embryo 02-04hr
(242)
embryo 04-06hr
(295)
embryo 06-08hr
(382)
embryo 08-10hr
(279)
embryo 10-12hr
(181)
embryo 12-14hr
(152)
embryo 14-16hr
102
embryo 16-18hr
77
embryo 18-20hr
42
embryo 20-22hr
51
embryo 22-24hr
54
larva L1
62
larva L2
65
larva L3 12hr old
41
larva L3 puffstage 1-2
35
larva L3 puffstage 3-6
56
larva L3 puffstage 7-9
67
white prepupae new
64
white prepupae 12hr
59
white prepupae 24hr
73
pupae 2d postWPP
38
pupae 3d postWPP
23
pupae 4d postWPP
20
adult male 01day
24
adult male 05day
24
adult male 30day
23
adult female 01day
59
adult female 05day
95
adult female 30day
91
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
169
embryo 02-04hr
242
embryo 04-06hr
295
embryo 06-08hr
382
embryo 08-10hr
279
embryo 10-12hr
181
embryo 12-14hr
152
embryo 14-16hr
102
embryo 16-18hr
77
embryo 18-20hr
42
embryo 20-22hr
51
embryo 22-24hr
54
larva L1
62
larva L2
65
larva L3 12hr old
41
larva L3 puffstage 1-2
35
larva L3 puffstage 3-6
56
larva L3 puffstage 7-9
67
white prepupae new
64
white prepupae 12hr
59
white prepupae 24hr
73
pupae 2d postWPP
38
pupae 3d postWPP
23
pupae 4d postWPP
20
adult male 01day
24
adult male 05day
24
adult male 30day
23
adult female 01day
59
adult female 05day
95
adult female 30day
91
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
321
Schneider line 2 Sg4
155
embryonic 1182-4H
180
embryonic GM2
211
embryonic Kc167
113
embryonic S1
297
embryonic S3
277
leg disc CME L1
231
wing disc CME-W2
127
wing disc ML-DmD8
199
wing disc ML-DmD9
216
wing disc ML-DmD16-c3
255
wing disc ML-DmD21
226
wing disc ML-DmD32
239
haltere disc ML-DmD17-c3
416
eye-antennal disc ML-DmD11
202
antennal disc ML-DmD20-c5
177
mixed discs ML-DmD4-c1
304
CNS ML-DmBG1-c1
245
CNS ML-DmBG2-c2
207
tumorous blood cells mbn2
298
ovary fGS/OSS
439
ovary OSC
330
ovary OSS
233
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(321)
Schneider line 2 Sg4
(155)
embryonic 1182-4H
(180)
embryonic GM2
(211)
embryonic Kc167
(113)
embryonic S1
(297)
embryonic S3
(277)
leg disc CME L1
(231)
wing disc CME-W2
(127)
wing disc ML-DmD8
(199)
wing disc ML-DmD9
(216)
wing disc ML-DmD16-c3
(255)
wing disc ML-DmD21
(226)
wing disc ML-DmD32
(239)
haltere disc ML-DmD17-c3
(416)
eye-antennal disc ML-DmD11
(202)
antennal disc ML-DmD20-c5
(177)
mixed discs ML-DmD4-c1
(304)
CNS ML-DmBG1-c1
(245)
CNS ML-DmBG2-c2
(207)
tumorous blood cells mbn2
(298)
ovary fGS/OSS
(439)
ovary OSC
(330)
ovary OSS
(233)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(321)
Schneider line 2 Sg4
(155)
embryonic 1182-4H
(180)
embryonic GM2
(211)
embryonic Kc167
(113)
embryonic S1
(297)
embryonic S3
(277)
leg disc CME L1
(231)
wing disc CME-W2
(127)
wing disc ML-DmD8
(199)
wing disc ML-DmD9
(216)
wing disc ML-DmD16-c3
(255)
wing disc ML-DmD21
(226)
wing disc ML-DmD32
(239)
haltere disc ML-DmD17-c3
(416)
eye-antennal disc ML-DmD11
(202)
antennal disc ML-DmD20-c5
(177)
mixed discs ML-DmD4-c1
(304)
CNS ML-DmBG1-c1
(245)
CNS ML-DmBG2-c2
(207)
tumorous blood cells mbn2
(298)
ovary fGS/OSS
(439)
ovary OSC
(330)
ovary OSS
(233)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
321
Schneider line 2 Sg4
155
embryonic 1182-4H
180
embryonic GM2
211
embryonic Kc167
113
embryonic S1
297
embryonic S3
277
leg disc CME L1
231
wing disc CME-W2
127
wing disc ML-DmD8
199
wing disc ML-DmD9
216
wing disc ML-DmD16-c3
255
wing disc ML-DmD21
226
wing disc ML-DmD32
239
haltere disc ML-DmD17-c3
416
eye-antennal disc ML-DmD11
202
antennal disc ML-DmD20-c5
177
mixed discs ML-DmD4-c1
304
CNS ML-DmBG1-c1
245
CNS ML-DmBG2-c2
207
tumorous blood cells mbn2
298
ovary fGS/OSS
439
ovary OSC
330
ovary OSS
233
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
321
Schneider line 2 Sg4
155
embryonic 1182-4H
180
embryonic GM2
211
embryonic Kc167
113
embryonic S1
297
embryonic S3
277
leg disc CME L1
231
wing disc CME-W2
127
wing disc ML-DmD8
199
wing disc ML-DmD9
216
wing disc ML-DmD16-c3
255
wing disc ML-DmD21
226
wing disc ML-DmD32
239
haltere disc ML-DmD17-c3
416
eye-antennal disc ML-DmD11
202
antennal disc ML-DmD20-c5
177
mixed discs ML-DmD4-c1
304
CNS ML-DmBG1-c1
245
CNS ML-DmBG2-c2
207
tumorous blood cells mbn2
298
ovary fGS/OSS
439
ovary OSC
330
ovary OSS
233
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(321)
Schneider line 2 Sg4
(155)
embryonic 1182-4H
(180)
embryonic GM2
(211)
embryonic Kc167
(113)
embryonic S1
(297)
embryonic S3
(277)
leg disc CME L1
(231)
wing disc CME-W2
(127)
wing disc ML-DmD8
(199)
wing disc ML-DmD9
(216)
wing disc ML-DmD16-c3
(255)
wing disc ML-DmD21
(226)
wing disc ML-DmD32
(239)
haltere disc ML-DmD17-c3
(416)
eye-antennal disc ML-DmD11
(202)
antennal disc ML-DmD20-c5
(177)
mixed discs ML-DmD4-c1
(304)
CNS ML-DmBG1-c1
(245)
CNS ML-DmBG2-c2
(207)
tumorous blood cells mbn2
(298)
ovary fGS/OSS
(439)
ovary OSC
(330)
ovary OSS
(233)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(321)
Schneider line 2 Sg4
(155)
embryonic 1182-4H
(180)
embryonic GM2
(211)
embryonic Kc167
113
embryonic S1
(297)
embryonic S3
(277)
leg disc CME L1
(231)
wing disc CME-W2
127
wing disc ML-DmD8
(199)
wing disc ML-DmD9
(216)
wing disc ML-DmD16-c3
(255)
wing disc ML-DmD21
(226)
wing disc ML-DmD32
(239)
haltere disc ML-DmD17-c3
(416)
eye-antennal disc ML-DmD11
(202)
antennal disc ML-DmD20-c5
(177)
mixed discs ML-DmD4-c1
(304)
CNS ML-DmBG1-c1
(245)
CNS ML-DmBG2-c2
(207)
tumorous blood cells mbn2
(298)
ovary fGS/OSS
(439)
ovary OSC
(330)
ovary OSS
(233)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
321
Schneider line 2 Sg4
155
embryonic 1182-4H
180
embryonic GM2
211
embryonic Kc167
113
embryonic S1
297
embryonic S3
277
leg disc CME L1
231
wing disc CME-W2
127
wing disc ML-DmD8
199
wing disc ML-DmD9
216
wing disc ML-DmD16-c3
255
wing disc ML-DmD21
226
wing disc ML-DmD32
239
haltere disc ML-DmD17-c3
416
eye-antennal disc ML-DmD11
202
antennal disc ML-DmD20-c5
177
mixed discs ML-DmD4-c1
304
CNS ML-DmBG1-c1
245
CNS ML-DmBG2-c2
207
tumorous blood cells mbn2
298
ovary fGS/OSS
439
ovary OSC
330
ovary OSS
233
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
97
cold shock, 4-day adult
71
heat shock, 4-day adult
95
Cadmium 50 mM 6 hrs, larvae L3
48
Cadmium 50 mM 12 hrs, larvae L3
66
Cadmium 50 mM 48 hrs, 4-day adult
115
Cadmium 100 mM 48 hrs, 4-day adult
241
Copper 0.5 mM 12 hrs, larvae L3
68
Copper 15 mM 48 hrs, 4-day adult
285
Zinc 5 mM 12 hrs, larvae L3
58
Zinc 4.5 mM 48 hrs, 4-day adult
130
Ethanol 2.5% 3 hrs, larvae L3
144
Ethanol 5% 3 hrs, larvae L3
48
Ethanol 10% 3 hrs, larvae L3
47
Caffeine 1.5 mg/ml 4 hrs, larvae L3
39
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
211
Caffeine 25 mg/ml 48 hrs, 4-day adult
113
Paraquat 5 mM 48 hrs, 4-day adult
157
Paraquat 10 mM 48 hrs, 4-day adult
107
Rotenone 2 μg 12 hrs, larvae L3
49
Rotenone 8 μg 12 hrs, larvae L3
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(97)
cold shock, 4-day adult
(71)
heat shock, 4-day adult
(95)
Cadmium 50 mM 6 hrs, larvae L3
(48)
Cadmium 50 mM 12 hrs, larvae L3
(66)
Cadmium 50 mM 48 hrs, 4-day adult
(115)
Cadmium 100 mM 48 hrs, 4-day adult
(241)
Copper 0.5 mM 12 hrs, larvae L3
(68)
Copper 15 mM 48 hrs, 4-day adult
(285)
Zinc 5 mM 12 hrs, larvae L3
(58)
Zinc 4.5 mM 48 hrs, 4-day adult
(130)
Ethanol 2.5% 3 hrs, larvae L3
(144)
Ethanol 5% 3 hrs, larvae L3
(48)
Ethanol 10% 3 hrs, larvae L3
(47)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(39)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(211)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(113)
Paraquat 5 mM 48 hrs, 4-day adult
(157)
Paraquat 10 mM 48 hrs, 4-day adult
(107)
Rotenone 2 μg 12 hrs, larvae L3
(49)
Rotenone 8 μg 12 hrs, larvae L3
(41)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
97
cold shock, 4-day adult
71
heat shock, 4-day adult
95
Cadmium 50 mM 6 hrs, larvae L3
48
Cadmium 50 mM 12 hrs, larvae L3
66
Cadmium 50 mM 48 hrs, 4-day adult
(115)
Cadmium 100 mM 48 hrs, 4-day adult
(241)
Copper 0.5 mM 12 hrs, larvae L3
68
Copper 15 mM 48 hrs, 4-day adult
(285)
Zinc 5 mM 12 hrs, larvae L3
58
Zinc 4.5 mM 48 hrs, 4-day adult
(130)
Ethanol 2.5% 3 hrs, larvae L3
(144)
Ethanol 5% 3 hrs, larvae L3
48
Ethanol 10% 3 hrs, larvae L3
47
Caffeine 1.5 mg/ml 4 hrs, larvae L3
39
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(211)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(113)
Paraquat 5 mM 48 hrs, 4-day adult
(157)
Paraquat 10 mM 48 hrs, 4-day adult
107
Rotenone 2 μg 12 hrs, larvae L3
49
Rotenone 8 μg 12 hrs, larvae L3
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
97
cold shock, 4-day adult
71
heat shock, 4-day adult
95
Cadmium 50 mM 6 hrs, larvae L3
48
Cadmium 50 mM 12 hrs, larvae L3
66
Cadmium 50 mM 48 hrs, 4-day adult
115
Cadmium 100 mM 48 hrs, 4-day adult
241
Copper 0.5 mM 12 hrs, larvae L3
68
Copper 15 mM 48 hrs, 4-day adult
285
Zinc 5 mM 12 hrs, larvae L3
58
Zinc 4.5 mM 48 hrs, 4-day adult
130
Ethanol 2.5% 3 hrs, larvae L3
144
Ethanol 5% 3 hrs, larvae L3
48
Ethanol 10% 3 hrs, larvae L3
47
Caffeine 1.5 mg/ml 4 hrs, larvae L3
39
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
211
Caffeine 25 mg/ml 48 hrs, 4-day adult
113
Paraquat 5 mM 48 hrs, 4-day adult
157
Paraquat 10 mM 48 hrs, 4-day adult
107
Rotenone 2 μg 12 hrs, larvae L3
49
Rotenone 8 μg 12 hrs, larvae L3
41
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
97
cold shock, 4-day adult
71
heat shock, 4-day adult
95
Cadmium 50 mM 6 hrs, larvae L3
48
Cadmium 50 mM 12 hrs, larvae L3
66
Cadmium 50 mM 48 hrs, 4-day adult
115
Cadmium 100 mM 48 hrs, 4-day adult
241
Copper 0.5 mM 12 hrs, larvae L3
68
Copper 15 mM 48 hrs, 4-day adult
285
Zinc 5 mM 12 hrs, larvae L3
58
Zinc 4.5 mM 48 hrs, 4-day adult
130
Ethanol 2.5% 3 hrs, larvae L3
144
Ethanol 5% 3 hrs, larvae L3
48
Ethanol 10% 3 hrs, larvae L3
47
Caffeine 1.5 mg/ml 4 hrs, larvae L3
39
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
211
Caffeine 25 mg/ml 48 hrs, 4-day adult
113
Paraquat 5 mM 48 hrs, 4-day adult
157
Paraquat 10 mM 48 hrs, 4-day adult
107
Rotenone 2 μg 12 hrs, larvae L3
49
Rotenone 8 μg 12 hrs, larvae L3
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(97)
cold shock, 4-day adult
(71)
heat shock, 4-day adult
(95)
Cadmium 50 mM 6 hrs, larvae L3
(48)
Cadmium 50 mM 12 hrs, larvae L3
(66)
Cadmium 50 mM 48 hrs, 4-day adult
(115)
Cadmium 100 mM 48 hrs, 4-day adult
(241)
Copper 0.5 mM 12 hrs, larvae L3
(68)
Copper 15 mM 48 hrs, 4-day adult
(285)
Zinc 5 mM 12 hrs, larvae L3
(58)
Zinc 4.5 mM 48 hrs, 4-day adult
(130)
Ethanol 2.5% 3 hrs, larvae L3
(144)
Ethanol 5% 3 hrs, larvae L3
(48)
Ethanol 10% 3 hrs, larvae L3
(47)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(39)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(211)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(113)
Paraquat 5 mM 48 hrs, 4-day adult
(157)
Paraquat 10 mM 48 hrs, 4-day adult
(107)
Rotenone 2 μg 12 hrs, larvae L3
(49)
Rotenone 8 μg 12 hrs, larvae L3
(41)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
97
cold shock, 4-day adult
71
heat shock, 4-day adult
95
Cadmium 50 mM 6 hrs, larvae L3
48
Cadmium 50 mM 12 hrs, larvae L3
66
Cadmium 50 mM 48 hrs, 4-day adult
115
Cadmium 100 mM 48 hrs, 4-day adult
(241)
Copper 0.5 mM 12 hrs, larvae L3
68
Copper 15 mM 48 hrs, 4-day adult
(285)
Zinc 5 mM 12 hrs, larvae L3
58
Zinc 4.5 mM 48 hrs, 4-day adult
130
Ethanol 2.5% 3 hrs, larvae L3
(144)
Ethanol 5% 3 hrs, larvae L3
48
Ethanol 10% 3 hrs, larvae L3
47
Caffeine 1.5 mg/ml 4 hrs, larvae L3
39
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(211)
Caffeine 25 mg/ml 48 hrs, 4-day adult
113
Paraquat 5 mM 48 hrs, 4-day adult
(157)
Paraquat 10 mM 48 hrs, 4-day adult
107
Rotenone 2 μg 12 hrs, larvae L3
49
Rotenone 8 μg 12 hrs, larvae L3
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
97
cold shock, 4-day adult
71
heat shock, 4-day adult
95
Cadmium 50 mM 6 hrs, larvae L3
48
Cadmium 50 mM 12 hrs, larvae L3
66
Cadmium 50 mM 48 hrs, 4-day adult
115
Cadmium 100 mM 48 hrs, 4-day adult
241
Copper 0.5 mM 12 hrs, larvae L3
68
Copper 15 mM 48 hrs, 4-day adult
285
Zinc 5 mM 12 hrs, larvae L3
58
Zinc 4.5 mM 48 hrs, 4-day adult
130
Ethanol 2.5% 3 hrs, larvae L3
144
Ethanol 5% 3 hrs, larvae L3
48
Ethanol 10% 3 hrs, larvae L3
47
Caffeine 1.5 mg/ml 4 hrs, larvae L3
39
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
211
Caffeine 25 mg/ml 48 hrs, 4-day adult
113
Paraquat 5 mM 48 hrs, 4-day adult
157
Paraquat 10 mM 48 hrs, 4-day adult
107
Rotenone 2 μg 12 hrs, larvae L3
49
Rotenone 8 μg 12 hrs, larvae L3
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 3 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 6 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Partially disrupted in Transgenic Constructs & Insertions
Transgenic Constructs characterization construct
Insertions insertion of mobile activating element
insertion of enhancer trap
Gene Ontology: Function, Process
& Cellular Component ( 5 unique terms )There is no information supporting a
cellular component term for this gene.
(Based on a review of available data on: 2008-03-20)
Terms Based on
Experimental Evidence ( 1 term ) Molecular Function ( 0 terms) Biological Process ( 0 terms) Cellular Component inferred from direct assay
Terms Based on Predictions or
Assertions ( 4 terms ) Molecular Function inferred from sequence or structural similarity with
EMBL:AE000670 Biological Process Cellular Component ( 0 terms) Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (43)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6MSDHW )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6P2Q9M )
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG69P8VJ )
Apis mellifera
Western honey bee
Amel\GB55383
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013433
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH13765
Atta cephalotes
Leafcutter ant
Acep\ACEP23162
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO19004
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL19921
Linepithema humile
Argentine ant
Lhum\LH14957
Solenopsis invicta
Red fire ant
Sinv\SINV18962
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG6RJDHK )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG6TBH4J )
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Xenopus tropicalis
Western clawed frog
Gallus gallus
Domestic chicken
Rattus norvegicus
Norway rat
Human Orthologs (1)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 6 )Bloomington Kyoto VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 245 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Source for merge of: BEST:LD29743 CG4747
Source for merge of: CG4747 BEST:GH19401
Additional comments Other Comments External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 6 )Reported As Symbol Synonym CG4747
(
Quinones-Coello, 2007 ,
Akdemir et al., 2007 ,
Varma and Mishra, 2011 ,
Keleman et al., 2009.8.5 ,
Ni et al., 2010.12.1 ,
Cammarato et al., 2011 ,
Wang et al., 2013 )
Name Synonym Secondary FlyBase
IDs FBgn0026572 FBgn0032174 FBgn0041705 References ( 27 )Generate a list of List References by type
Recent research papers ( 2 )
Wang et al., 2013, Nat. Struct. Mol. Biol. 20(2): 202--209Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. [FBrf0220693] Varma and Mishra, 2011, J. Biosci., Bangalore 36(3): 439--459Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster. [FBrf0214552]
Recent reviews (0)
All reviews listed in FlyBase were published before 2011