FlyBase Gene Report: Dmel\PGRP-SC2

General Information

Symbol

Dmel\PGRP-SC2

Species

D. melanogaster

Name

Peptidoglycan recognition protein SC2

Annotation Symbol

CG14745

Feature Type

protein_coding_gene

FlyBase ID

FBgn0043575

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Snapshot

Peptidoglycan recognition protein SC2 (PGRP-SC2) encodes a secreted peptidoglycan recognition protein (PGRP) with an amidase activity against peptidoglycans. It contributes to the down-regulation of the immune deficiency pathway, notably in the fat body during systemic bacterial infection. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

PGRP-SC, Peptidoglycan-recognition protein-SC2 precursor

Key Links

Genomic Location

Cytogenetic map

44E2-44E2

Sequence location

2R:8,716,950..8,717,695 [+]

Recombination map

2-59

RefSeq locus

NT_033778 REGION:8716950..8717695

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables N-acetylmuramoyl-L-alanine amidase activity

inferred from sequence or structural similarity with FLYBASE:PGRP-SC1b; FB:FBgn0033327

(Mellroth et al., 2003)

enables peptidoglycan binding

inferred from electronic annotation with InterPro:IPR017331

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR006619

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

inferred from genetic interaction with FLYBASE:PGRP-SC1a; FB:FBgn0043576, FLYBASE:PGRP-SB2; FB:FBgn0043577

(Bischoff et al., 2006)

inferred from mutant phenotype

(Costechareyre et al., 2016)

involved_in negative regulation of peptidoglycan recognition protein signaling pathway

inferred from mutant phenotype

(Costechareyre et al., 2016)

inferred from genetic interaction with FLYBASE:PGRP-SC1a; FB:FBgn0043576, FLYBASE:PGRP-SB2; FB:FBgn0043577

(Bischoff et al., 2006)

involved_in positive regulation of Toll signaling pathway

inferred from mutant phenotype

(Costechareyre et al., 2016)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in immune response

inferred from sequence or structural similarity with UniProtKB:O76537

(Werner et al., 2000)

involved_in innate immune response

inferred from electronic annotation with InterPro:IPR017331

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in peptidoglycan catabolic process

inferred from sequence or structural similarity with FLYBASE:PGRP-SC1b; FB:FBgn0033327

(Mellroth et al., 2003)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from sequence or structural similarity

(Steiner, 2004, Werner et al., 2000)

Gene Group (FlyBase)

SHORT PEPTIDOGLYCAN RECOGNITION PROTEINS

N-ACETYLMURAMOYL-L-ALANINE AMIDASES

Pathway (FlyBase)

Negative Regulators of Imd Signaling Pathway

Extracellular Spatzle Activating Pathway Core Components

Protein Family (UniProt)

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (Q9V4X2)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

SHORT PEPTIDOGLYCAN RECOGNITION PROTEINS -: Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules of the innate immune response that bind peptidoglycans. Insect PGRPs can be divided into two groups based on transcript size: short PGRPs (PGRP-S) and long PGRPs (PGRP-L). PGRP-S have signal peptides and can be extracellular proteins. (Adapted from FBrf0223078).
N-ACETYLMURAMOYL-L-ALANINE AMIDASES -: N-acetylmuramoyl-L-alanine amidases catalyze the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.

Pathway (FlyBase)

Negative Regulators of Imd Signaling Pathway -: Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)
Extracellular Spatzle Activating Pathway Core Components -: In Drosophila, activation of the Toll pathway is controlled by the generation of a cleaved, active, Toll-binding form of spatzle ligand. Proteolytic activation of spatzle ligand lies downstream of several zymogen activation cascades that are initiated by different cues. In dorsal-ventral patterning, localized activation of spz results in ventral nuclear accumulation of dl. During viral and fungal and gram positive bacterial immune challenge, zymogen cascades are activated by extracellular pattern recognition receptors or virulence factor-mediated cleavage of the zymogen persephone (psh). (Adapted from FBrf0091014 and FBrf0223077).

Protein Function (UniProtKB)

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity).

(UniProt, Q9V4X2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\PGRP-SC2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

PGRP-SC2-RA

FBtr0088709

NM_136566

746

184

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

PGRP-SC2-PA

FBpp0087788

19.8

184

8.87

NP_610410

AAF59051

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PGRP-SC2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PGRP-SC2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval gut

(Costechareyre et al., 2016)

embryonic/larval proventriculus

(Costechareyre et al., 2016)

Additional Descriptive Data

PGRP-SC2 is expressed in the gut and proventriculus and levels are tied to the immune response.

(Costechareyre et al., 2016)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\PGRP-SC2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\PGRP-SC2

View exonic expression by tissue for Dmel\PGRP-SC2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0043575

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14745-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0043575

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of PGRP-SC2

Transgenic constructs containing regulatory region of PGRP-SC2

Deletions and Duplications ( 2 )

Disrupted in

Df(2R)Exel7098

(Ryder, 2004.4.26)

Df(2R)PGRP-SC^Δ

(Paredes et al., 2011)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

PGRP-SC2^GD1639

viable, with Scer\GAL4^pnr-MD237

PGRP-SC2^GD1639

Other Phenotypes

Allele

decreased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

PGRP-SC2^UAS.cGa

decreased occurrence of cell division | adult stage | RU486 conditional, with Scer\GAL4^GSG5966

PGRP-SC2^UAS.cGa

immune response defective | adult stage

PGRP-SC2^KO

long lived, with Scer\GAL4^NP0001

PGRP-SC2^UAS.cGa

long lived | RU486 conditional, with Scer\GAL4^GSG5966

PGRP-SC2^UAS.cGa

Phenotype manifest in

Allele

intestinal stem cell, with Scer\GAL4^NP0001

PGRP-SC2^UAS.cGa

intestinal stem cell | RU486 conditional, with Scer\GAL4^GSG5966

PGRP-SC2^UAS.cGa

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PGLYRP1

11 of 15

Yes

6 of 15

5 of 15

2 of 15

1 of 15

Yes

Hsap\CA7

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Pglyrp1

12 of 15

Yes

Mmus\Pglyrp4

7 of 15

Mmus\Pglyrp3

5 of 15

Mmus\Pglyrp2

3 of 15

Rattus norvegicus (Norway rat) (6)

Rnor\Pglyrp1

10 of 13

Yes

6 of 13

5 of 13

4 of 13

2 of 13

Yes

Rnor\Pglyrp2

2 of 13

Xenopus tropicalis (Western clawed frog) (3)

Xtro\pglyrp1

10 of 12

Yes

Xtro\pglyrp1-like.1

9 of 12

Yes

Xtro\pglyrp2

2 of 12

Danio rerio (Zebrafish) (3)

Drer\pglyrp5

6 of 15

Yes

Drer\pglyrp6

4 of 15

Drer\pglyrp2

3 of 15

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\mig-39

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190G39 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13217

Drosophila willistoni

Dwil\GK21737

Drosophila virilis

Dvir\GJ21836

Drosophila virilis

Dvir\GJ20505

Drosophila mojavensis

Dmoj\GI18809

Drosophila grimshawi

Dgri\GH21354

Drosophila grimshawi

Dgri\GH20540

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150D0T )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17020756

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09762

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09764

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0F52 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA012866

Bombyx mori

Silkmoth

Bmor\BGIBMGA008038

Bombyx mori

Silkmoth

Bmor\BGIBMGA007987

Danaus plexippus

Monarch butterfly

Dple\DPOGS206909-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS209814-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS209813-PA

Heliconius melpomene

Postman butterfly

Hmel\PGRP-B

Heliconius melpomene

Postman butterfly

Hmel\PGRP-G

Heliconius melpomene

Postman butterfly

Hmel\PGRP-A

Apis florea

Little honeybee

Aflo\4046469156

Apis florea

Little honeybee

Aflo\3037783764

Apis mellifera

Western honey bee

Amel\Pgrp-s2

Apis mellifera

Western honey bee

Amel\PGRP-S3

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15194

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24867

Bombus terrestris

Buff-tailed bumblebee

Bter\15208577

Bombus terrestris

Buff-tailed bumblebee

Bter\15209974

Linepithema humile

Argentine ant

Lhum\LH22370

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00190c

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG018589

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11242

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_15689

Tribolium castaneum

Red flour beetle

Tcas\TC010611

Rhodnius prolixus

Kissing bug

Rpro\RPRC012777

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09910

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09909

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_07518

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0F4M )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR014273

Strigamia maritima

European centipede

Smar\SMAR007561

Strigamia maritima

European centipede

Smar\SMAR015602

Strigamia maritima

European centipede

Smar\SMAR010214

Strigamia maritima

European centipede

Smar\SMAR007559

Strigamia maritima

European centipede

Smar\SMAR014909

Strigamia maritima

European centipede

Smar\SMAR013411

Ixodes scapularis

Black-legged tick

Isca\ISCW022212

Stegodyphus mimosarum

African social velvet spider

Smim\KFM76783.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80660.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71057.1

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0O6Z )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pgrp2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pgrp4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pgrp3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pgrp1

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028631

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (13)

Gene Symbol

Score

Source

Alignment

7 of 10

6 of 10

6 of 10

5 of 10

5 of 10

5 of 10

5 of 10

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PGLYRP1; peptidoglycan recognition protein 1

11 of 15

604963

PGLYRP4; peptidoglycan recognition protein 4

6 of 15

608198

PGLYRP3; peptidoglycan recognition protein 3

5 of 15

608197

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Lam

suppressible

PGRP-LB|PGRP-SC2

(Chen et al., 2014)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0043575

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

35862

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of Imd Signaling Pathway -: Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)
Extracellular Spatzle Activating Pathway Core Components -: In Drosophila, activation of the Toll pathway is controlled by the generation of a cleaved, active, Toll-binding form of spatzle ligand. Proteolytic activation of spatzle ligand lies downstream of several zymogen activation cascades that are initiated by different cues. In dorsal-ventral patterning, localized activation of spz results in ventral nuclear accumulation of dl. During viral and fungal and gram positive bacterial immune challenge, zymogen cascades are activated by extracellular pattern recognition receptors or virulence factor-mediated cleavage of the zymogen persephone (psh). (Adapted from FBrf0091014 and FBrf0223077).

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Toll and Imd signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-59

Cytogenetic map

44E2-44E2

Sequence location

2R:8,716,950..8,717,695 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

44E2-44E2

Limits computationally determined from genome sequence between P{PZ}l(2)44DEa⁰⁵⁸⁴⁷ and P{lacW}Rya-r44F^k04913

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

44E-44E

(Werner et al., 2000)

Experimentally Determined Recombination Data

Location

2-59

(FlyBase, 2016)

2-57.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Bloomington

56915

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04353}attP40

VDRC

v104578

P{KK108802}VIE-260B

v52288

w¹¹¹⁸; P{GD17747}v52288

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0043575

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35862

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: PGRP-SC2 CG14745

(Werner et al., 2000)

Additional comments

Other Comments

Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.

(McDonald and Rosbash, 2001)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35862

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V4X2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q2XY98

Other crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PGRP-SC2_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0043575

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35862

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG14745

modMine - A data warehouse for the modENCODE project

FBgn0043575

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0043575

DRSC - Results frm RNAi screens

FBgn0043575

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0043575

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14745-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0043575

FlyMine - An integrated database for Drosophila genomics

FBgn0043575

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

35862

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Toll and Imd signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG14745

(Palu and Thummel, 2016, Petersen et al., 2012, Ni et al., 2010.12.1, Horner et al., 2009, Keleman et al., 2009.8.5, Hernandez-Romano et al., 2008, Pal et al., 2007, De Gregorio et al., 2001, Irving et al., 2001, McDonald and Rosbash, 2001)

CG14745 PGRP

(Sano et al., 2005)

PCRP-SC2

(Hang et al., 2014)

PGRP-SC

(Min and Tatar, 2018, Ryu et al., 2010, Ramet et al., 2002)

PGRP-SC2

(Benoit et al., 2020, Hung et al., 2020, Lu et al., 2020, Nishihara, 2020, Zhou and Boutros, 2020, Maitra et al., 2019, Sanuki et al., 2019, Hemphill et al., 2018, Musselman et al., 2018, Wang et al., 2018, Duneau et al., 2017, Yadav et al., 2017, Capo et al., 2016, Costechareyre et al., 2016, Castillo et al., 2015, Jasper, 2015, Kavi et al., 2015, Ma et al., 2015, Bonnay et al., 2014, Chen et al., 2014, Guo et al., 2014, Hang et al., 2014, Kurata, 2014, Myllymäki et al., 2014, Taylor et al., 2014, Ayyaz and Jasper, 2013, Marianes and Spradling, 2013, Petersen et al., 2013, Short and Lazzaro, 2013, Stefanatos et al., 2013, Telonis-Scott et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Kalajdzic et al., 2012, Petersen et al., 2012, Rynes et al., 2012, Marcu et al., 2011, Paredes et al., 2011, Valanne et al., 2011, Carpenter et al., 2009, Obbard et al., 2009, Ye et al., 2009, Zsindely et al., 2009, Wagner et al., 2008, Firth and Baker, 2007, Waterhouse et al., 2007, Zaidman-Remy et al., 2007, Bischoff et al., 2006, Lazzaro et al., 2006, Lazzaro et al., 2004, Roxstrom-Lindquist et al., 2004, Jiggins and Hurst, 2003, Mellroth et al., 2003, Christophides et al., 2002)

pgrp-sc

(Fink et al., 2016)

pgrp-sc2

(Fan et al., 2015)

Name Synonyms

PGRP-SC2

(Mossman et al., 2016)

Peptidoglycan recognition protein SC2

(Marcu et al., 2011)

Peptidoglycan-recognition protein-SC2 precursor

(Hernandez-Romano et al., 2008, Rollmann et al., 2008)

Secondary FlyBase IDs

FBgn0033328

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (108)

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