FB2019_05, released Oct 15, 2019

Gene: Dmel\PGRP-SC2

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General Information
Symbol
Dmel\PGRP-SC2
Species
D. melanogaster
Name
Peptidoglycan recognition protein SC2
Annotation Symbol
CG14745
Feature Type
protein_coding_gene
FlyBase ID
FBgn0043575
Gene Model Status
Current
Stock Availability
3 publicly available
Enzyme Name (EC)
N-acetylmuramoyl-L-alanine amidase (3.5.1.28)
Gene Snapshot
Peptidoglycan recognition protein SC2 (PGRP-SC2) encodes a secreted peptidoglycan recognition protein (PGRP) with an amidase activity against peptidoglycans. It contributes to the down-regulation of the immune deficiency pathway, notably in the fat body during systemic bacterial infection. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
PGRP-SC, Peptidoglycan-recognition protein-SC2 precursor
Key Links
Genomic Location
Cytogenetic map
44E2-44E2
Sequence location
2R:8,716,950..8,717,695 [+]
Recombination map
2-59
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (Q9V4X2)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
N-acetylmuramoyl-L-alanine amidase activity; peptidoglycan binding; peptidoglycan receptor activity; zinc ion binding
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides (3.5.1.28)
Summaries
Gene Group (FlyBase)
SHORT PEPTIDOGLYCAN RECOGNITION PROTEINS -
Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules of the innate immune response that bind peptidoglycans. Insect PGRPs can be divided into two groups based on transcript size: short PGRPs (PGRP-S) and long PGRPs (PGRP-L). PGRP-S have signal peptides and can be extracellular proteins. (Adapted from FBrf0223078).
Pathway (FlyBase)
Negative Regulators of Imd Signaling Pathway -
Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)
Extracellular Spatzle Activating Pathway Core Components -
In Drosophila, activation of the Toll pathway is controlled by the generation of a cleaved, active, Toll-binding form of spatzle ligand. Proteolytic activation of spatzle ligand lies downstream of several zymogen activation cascades that are initiated by different cues. In dorsal-ventral patterning, localized activation of spz results in ventral nuclear accumulation of dl. During viral and fungal and gram positive bacterial immune challenge, zymogen cascades are activated by extracellular pattern recognition receptors or virulence factor-mediated cleavage of the zymogen persephone (psh). (Adapted from FBrf0091014 and FBrf0223077).
Protein Function (UniProtKB)
N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity).
(UniProt, Q9V4X2)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\PGRP-SC2 or the JBrowse view of Dmel\PGRP-SC2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
PGRP-SC2-RA
FBtr0088709
NM_136566
746
184
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
PGRP-SC2-PA
FBpp0087788
19.8
184
8.87
NP_610410
AAF59051
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PGRP-SC2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (15 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
N-acetylmuramoyl-L-alanine amidase activity
inferred from biological aspect of ancestor with PANTHER:PTN001664864
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with FLYBASE:PGRP-SC1b; FB:FBgn0033327
(Mellroth et al., 2003)
peptidoglycan binding
inferred from biological aspect of ancestor with PANTHER:PTN001664863
(assigned by GO_Central )
(Gaudet et al., 2011)
peptidoglycan receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001664864
(assigned by GO_Central )
(Gaudet et al., 2011)
zinc ion binding
inferred from electronic annotation with InterPro:IPR006619
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
inferred from genetic interaction with FLYBASE:PGRP-SC1a; FB:FBgn0043576, FLYBASE:PGRP-SB2; FB:FBgn0043577
(Bischoff et al., 2006)
inferred from mutant phenotype
(Costechareyre et al., 2016)
negative regulation of peptidoglycan recognition protein signaling pathway
inferred from mutant phenotype
(Costechareyre et al., 2016)
inferred from genetic interaction with FLYBASE:PGRP-SC1a; FB:FBgn0043576, FLYBASE:PGRP-SB2; FB:FBgn0043577
(Bischoff et al., 2006)
positive regulation of Toll signaling pathway
inferred from mutant phenotype
(Costechareyre et al., 2016)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
antimicrobial humoral response
inferred from biological aspect of ancestor with PANTHER:PTN001336553
(assigned by GO_Central )
(Gaudet et al., 2011)
defense response to Gram-positive bacterium
inferred from biological aspect of ancestor with PANTHER:PTN001336553
(assigned by GO_Central )
(Gaudet et al., 2011)
immune response
inferred from sequence or structural similarity with UniProtKB:O76537
(Werner et al., 2000)
innate immune response
inferred from electronic annotation with InterPro:IPR017331
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
negative regulation of natural killer cell differentiation involved in immune response
inferred from biological aspect of ancestor with PANTHER:PTN001336553
(assigned by GO_Central )
(Gaudet et al., 2011)
peptidoglycan catabolic process
inferred from sequence or structural similarity with FLYBASE:PGRP-SC1b; FB:FBgn0033327
(Mellroth et al., 2003)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
extracellular region
inferred from sequence or structural similarity
(Steiner, 2004, Werner et al., 2000)
extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN001664863
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval gut
(Costechareyre et al., 2016)
embryonic/larval proventriculus
(Costechareyre et al., 2016)
Additional Descriptive Data
PGRP-SC2 is expressed in the gut and proventriculus and levels are tied to the immune response.
(Costechareyre et al., 2016)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\PGRP-SC2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of PGRP-SC2
Transgenic constructs containing regulatory region of PGRP-SC2
Deletions and Duplications ( 2 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PGLYRP1
11 of 15
Yes
Yes
 
Hsap\PGLYRP3
5 of 15
No
No
Hsap\PGLYRP4
5 of 15
No
No
Hsap\PGLYRP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Pglyrp1
12 of 15
Yes
Yes
Mmus\Pglyrp4
6 of 15
No
No
Mmus\Pglyrp3
5 of 15
No
No
Mmus\Pglyrp2
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
Rnor\Pglyrp1
10 of 13
Yes
Yes
Rnor\Pglyrp4
5 of 13
No
No
Rnor\Pglyrp3b
4 of 13
No
Yes
Rnor\Pglyrp3
3 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\pglyrp1
9 of 12
Yes
Yes
Xtro\pglyrp1
9 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
Drer\pglyrp5
7 of 15
Yes
Yes
Drer\pglyrp6
2 of 15
No
No
Drer\pglyrp2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190G39 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\PGRP-SC2
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006794
Drosophila simulans
Dsim\PGRP-SC2
Drosophila sechellia
Dsec\GM21061
Drosophila erecta
Dere\GG23381
Drosophila yakuba
Dyak\GE19223
Drosophila ananassae
Dana\GF19796
Drosophila pseudoobscura pseudoobscura
Dpse\GA13217
Drosophila willistoni
Dwil\GK21737
Drosophila virilis
Dvir\GJ21836
Drosophila virilis
Dvir\GJ20505
Drosophila mojavensis
Dmoj\GI18809
Drosophila grimshawi
Dgri\GH21354
Drosophila grimshawi
Dgri\GH20540
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150D0T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020756
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09762
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09764
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0F52 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012866
Bombyx mori
Silkmoth
Bmor\BGIBMGA008038
Bombyx mori
Silkmoth
Bmor\BGIBMGA007987
Danaus plexippus
Monarch butterfly
Dple\DPOGS206909-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209814-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209813-PA
Heliconius melpomene
Postman butterfly
Hmel\PGRP-B
Heliconius melpomene
Postman butterfly
Hmel\PGRP-G
Heliconius melpomene
Postman butterfly
Hmel\PGRP-A
Apis florea
Little honeybee
Aflo\4046469156
Apis florea
Little honeybee
Aflo\3037783764
Apis mellifera
Western honey bee
Amel\Pgrp-s2
Apis mellifera
Western honey bee
Amel\PGRP-S3
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15194
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24867
Bombus terrestris
Buff-tailed bumblebee
Bter\15208577
Bombus terrestris
Buff-tailed bumblebee
Bter\15209974
Linepithema humile
Argentine ant
Lhum\LH22370
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00190c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018589
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11242
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15689
Tribolium castaneum
Red flour beetle
Tcas\TC010611
Rhodnius prolixus
Kissing bug
Rpro\RPRC012777
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09910
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09909
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07518
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0F4M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014273
Strigamia maritima
European centipede
Smar\SMAR007561
Strigamia maritima
European centipede
Smar\SMAR015602
Strigamia maritima
European centipede
Smar\SMAR010214
Strigamia maritima
European centipede
Smar\SMAR007559
Strigamia maritima
European centipede
Smar\SMAR014909
Strigamia maritima
European centipede
Smar\SMAR013411
Ixodes scapularis
Black-legged tick
Isca\ISCW022212
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76783.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80660.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71057.1
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0O6Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pgrp2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pgrp4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pgrp3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pgrp1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028631
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (13)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
PGRP-SC1b
7 of 10
PGRP-SC1a
6 of 10
PGRP-SB1
5 of 10
PGRP-LB
4 of 10
PGRP-LF
4 of 10
PGRP-SA
4 of 10
PGRP-SD
4 of 10
PGRP-LA
2 of 10
PGRP-LC
2 of 10
PGRP-LE
2 of 10
PGRP-SB2
2 of 10
CG9380
1 of 10
PGRP-LD
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PGLYRP1; peptidoglycan recognition protein 1
    11 of 15
    604963
         
        PGLYRP3; peptidoglycan recognition protein 3
        5 of 15
        608197
            PGLYRP4; peptidoglycan recognition protein 4
            5 of 15
            608198
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Interactions Browser
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Lam
                suppressible
                PGRP-LB|PGRP-SC2
                (Chen et al., 2014)
                External Data
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                Pathways
                Gene Group - Pathway Membership (FlyBase)
                Negative Regulators of Imd Signaling Pathway -
                Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)
                Extracellular Spatzle Activating Pathway Core Components -
                In Drosophila, activation of the Toll pathway is controlled by the generation of a cleaved, active, Toll-binding form of spatzle ligand. Proteolytic activation of spatzle ligand lies downstream of several zymogen activation cascades that are initiated by different cues. In dorsal-ventral patterning, localized activation of spz results in ventral nuclear accumulation of dl. During viral and fungal and gram positive bacterial immune challenge, zymogen cascades are activated by extracellular pattern recognition receptors or virulence factor-mediated cleavage of the zymogen persephone (psh). (Adapted from FBrf0091014 and FBrf0223077).
                External Data
                Linkouts
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2R
                Recombination map
                2-59
                Cytogenetic map
                44E2-44E2
                Sequence location
                2R:8,716,950..8,717,695 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                44E2-44E2
                Limits computationally determined from genome sequence between P{PZ}l(2)44DEa05847 and P{lacW}Rya-r44Fk04913
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                44E-44E
                (Werner et al., 2000)
                Experimentally Determined Recombination Data
                Location
                2-59
                (FlyBase, 2016)
                2-57.8
                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (3)
                Genomic Clones (12)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (0)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                  Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                        Other clones
                          RNAi and Array Information
                          Linkouts
                          DRSC - Results frm RNAi screens
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          Antibody Information
                          Laboratory Generated Antibodies
                           
                          Commercially Available Antibodies
                           
                          Other Information
                          Relationship to Other Genes
                          Source for database identify of
                          Source for database merge of
                          Source for merge of: PGRP-SC2 CG14745
                          (Werner et al., 2000)
                          Additional comments
                          Other Comments
                          Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.
                          (McDonald and Rosbash, 2001)
                          Origin and Etymology
                          Discoverer
                          Etymology
                          Identification
                          External Crossreferences and Linkouts ( 54 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          Flygut - An atlas of the Drosophila adult midgut
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                          modMine - A data warehouse for the modENCODE project
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          Linkouts
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyMine - An integrated database for Drosophila genomics
                          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          Synonyms and Secondary IDs (9)
                          Reported As
                          Symbol Synonym
                          CG14745
                          (Palu and Thummel, 2016, Petersen et al., 2012, Ni et al., 2010.12.1, Horner et al., 2009, Keleman et al., 2009.8.5, Hernandez-Romano et al., 2008, Pal et al., 2007, De Gregorio et al., 2001, Irving et al., 2001, McDonald and Rosbash, 2001)
                          CG14745 PGRP
                          (Sano et al., 2005)
                          PCRP-SC2
                          (Hang et al., 2014)
                          PGRP-SC
                          (Min and Tatar, 2018, Ryu et al., 2010, Ramet et al., 2002)
                          PGRP-SC2
                          (Sanuki et al., 2019, Hemphill et al., 2018, Wang et al., 2018, Duneau et al., 2017, Yadav et al., 2017, Capo et al., 2016, Costechareyre et al., 2016, Castillo et al., 2015, Jasper, 2015, Kavi et al., 2015, Ma et al., 2015, Bonnay et al., 2014, Chen et al., 2014, Guo et al., 2014, Hang et al., 2014, Kurata, 2014, Myllymäki et al., 2014, Taylor et al., 2014, Ayyaz and Jasper, 2013, Marianes and Spradling, 2013, Petersen et al., 2013, Short and Lazzaro, 2013, Stefanatos et al., 2013, Telonis-Scott et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Kalajdzic et al., 2012, Petersen et al., 2012, Rynes et al., 2012, Marcu et al., 2011, Paredes et al., 2011, Valanne et al., 2011, Carpenter et al., 2009, Obbard et al., 2009, Ye et al., 2009, Zsindely et al., 2009, Wagner et al., 2008, Firth and Baker, 2007, Waterhouse et al., 2007, Zaidman-Remy et al., 2007, Bischoff et al., 2006, Lazzaro et al., 2006, Lazzaro et al., 2004, Roxstrom-Lindquist et al., 2004, Jiggins and Hurst, 2003, Mellroth et al., 2003, Christophides et al., 2002)
                          pgrp-sc
                          (Fink et al., 2016)
                          pgrp-sc2
                          (Fan et al., 2015)
                          Name Synonyms
                          PGRP-SC2
                          (Mossman et al., 2016)
                          Peptidoglycan recognition protein SC2
                          (Marcu et al., 2011)
                          Peptidoglycan-recognition protein-SC2 precursor
                          (Hernandez-Romano et al., 2008, Rollmann et al., 2008)
                          Secondary FlyBase IDs
                          • FBgn0033328
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
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                          References (99)