FB2020_06, released Dec 22, 2020

Gene: Dmel\phu

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General Information
Symbol
Dmel\phu
Species
D. melanogaster
Name
phurba tashi
Annotation Symbol
CG8147
Feature Type
protein_coding_gene
FlyBase ID
FBgn0043791
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

BEST:LD38109

Key Links
Genomic Location
Cytogenetic map
85D18-85D18
Sequence location
3R:9,494,801..9,496,723 [+]
Recombination map

3-48

RefSeq locus
NT_033777 REGION:9494801..9496723
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables alkaline phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000174527
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:439
(FlyBase Curators, 2008--)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in response to hypoxia
inferred from mutant phenotype
(Jha et al., 2016)
involved_in response to nicotine
inferred from expression pattern
(Passador-Gurgel et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in dephosphorylation
inferred from sequence or structural similarity with HGNC:439
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000174527
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cell surface
inferred from sequence or structural similarity with HGNC:439
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ALKALINE PHOSPHATASES -
Alkaline phosphatases function best in alkaline environments, catalyzing the hydrolysis of monoesters of phosphoric acid and a transphosphorylation reaction in the presence of large concentrations of phosphate acceptors. With few exceptions, they are homodimeric enzymes and each catalytic site contains three metal ions, i.e., two Zn and one Mg, necessary for enzymatic activity. They have broad substrate specificity. (Adapted from PMID:18404473.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\phu for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
phu-RA
FBtr0082060
NM_141640
1862
546
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
phu-PA
FBpp0081538
59.5
546
6.38
NP_649897
AAF54384
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\phu using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
fat body/gonad primordium
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
procrystal cell
(Fisher et al., 2012)
stomatogastric nervous system primordium
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval dorsal vessel
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
plasmatocyte
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 5 -- 7
amnioserosa anlage
(Dominguez et al., 2016)
dorsal ectoderm
(Dominguez et al., 2016)
embryonic stage 11 -- 13
cardiogenic mesoderm
(Ahmad et al., 2012)
embryonic stage 16 -- 17
embryonic/larval heart
(Ahmad et al., 2012)
embryonic/larval cardial cell | subset
(Ahmad et al., 2012)
embryonic stage 16
embryonic/larval ostium
(Trujillo et al., 2016)
embryonic stage 15
embryonic/larval ostium
(Chen et al., 2016)
Additional Descriptive Data
Marker for
 
embryonic/larval ostium
(Chen et al., 2016)
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\phu in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of phu
Transgenic constructs containing regulatory region of phu
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
Other Phenotypes
Allele
stress response defective, with Scer\GAL4da.G32
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ALPG
12 of 15
Yes
Yes
Hsap\ALPI
12 of 15
Yes
No
Hsap\ALPL
12 of 15
Yes
Yes
Hsap\ALPP
11 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Akp3
11 of 15
Yes
No
Mmus\Alpl
11 of 15
Yes
No
Mmus\Alpi
10 of 15
No
No
Mmus\Alppl2
10 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Alpl
11 of 13
Yes
Yes
Rnor\Alpi
10 of 13
No
Yes
Rnor\Akp3
7 of 13
No
No
Rnor\Alpg
6 of 13
No
Yes
Rnor\Alpp
6 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\alpl
8 of 12
Yes
Yes
Xtro\alpi.1
7 of 12
No
No
Xtro\alpi.2
2 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\alpi.2
11 of 15
Yes
No
Drer\alpl
11 of 15
Yes
No
Drer\alp3
9 of 15
No
Yes
Drer\alpi.1
6 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PHO8
9 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC14F5.13c
7 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906P7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011460
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012634
Drosophila simulans
Dsim\GD18617
Drosophila sechellia
Dsec\GM23808
Drosophila erecta
Dere\GG16809
Drosophila yakuba
Dyak\GE25953
Drosophila ananassae
Dana\GF17216
Drosophila pseudoobscura pseudoobscura
Dpse\GA20850
Drosophila persimilis
Dper\GL13610
Drosophila willistoni
Dwil\GK10963
Drosophila virilis
Dvir\GJ23643
Drosophila mojavensis
Dmoj\GI24012
Drosophila grimshawi
Dgri\GH18436
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500QL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023077
Musca domestica
House fly
Mdoa\17019616
Musca domestica
House fly
Mdoa\17011013
Musca domestica
House fly
Mdoa\17019799
Musca domestica
House fly
Mdoa\17017449
Musca domestica
House fly
Mdoa\17004404
Musca domestica
House fly
Mdoa\17011281
Musca domestica
House fly
Mdoa\17024992
Musca domestica
House fly
Mdoa\17014983
Musca domestica
House fly
Mdoa\17004403
Musca domestica
House fly
Mdoa\17019800
Musca domestica
House fly
Mdoa\17023078
Musca domestica
House fly
Mdoa\17004433
Musca domestica
House fly
Mdoa\17021368
Musca domestica
House fly
Mdoa\17019801
Musca domestica
House fly
Mdoa\17021367
Musca domestica
House fly
Mdoa\17025826
Musca domestica
House fly
Mdoa\17012766
Musca domestica
House fly
Mdoa\17017448
Glossina morsitans
Tsetse fly
Gmor\GMOY009926
Glossina morsitans
Tsetse fly
Gmor\GMOY004796
Glossina morsitans
Tsetse fly
Gmor\GMOY006875
Glossina morsitans
Tsetse fly
Gmor\GMOY000067
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12143
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08183
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00691
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12140
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12139
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07241
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08180
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09942
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00688
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12138
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06150
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14111
Mayetiola destructor
Hessian fly
Mdes\Mdes009553
Mayetiola destructor
Hessian fly
Mdes\Mdes014146
Mayetiola destructor
Hessian fly
Mdes\Mdes008467
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003298
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009077
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003289
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003297
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003905
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003309
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003286
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003313
Anopheles darlingi
American malaria mosquito
Adar\ADAC001891
Anopheles darlingi
American malaria mosquito
Adar\ADAC001892
Anopheles darlingi
American malaria mosquito
Adar\ADAC002767
Anopheles darlingi
American malaria mosquito
Adar\ADAC006259
Anopheles darlingi
American malaria mosquito
Adar\ADAC002429
Anopheles gambiae
Malaria mosquito
Agam\AGAP007300
Anopheles gambiae
Malaria mosquito
Agam\AGAP011303
Anopheles gambiae
Malaria mosquito
Agam\AGAP012589
Anopheles gambiae
Malaria mosquito
Agam\AGAP011302
Anopheles gambiae
Malaria mosquito
Agam\AGAP011305
Anopheles gambiae
Malaria mosquito
Agam\AGAP028096
Anopheles gambiae
Malaria mosquito
Agam\AGAP001684
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002095
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001265
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001263
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001264
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018121
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W071J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011462
Bombyx mori
Silkmoth
Bmor\BGIBMGA014304
Bombyx mori
Silkmoth
Bmor\BGIBMGA009872
Bombyx mori
Silkmoth
Bmor\BGIBMGA008818
Bombyx mori
Silkmoth
Bmor\BGIBMGA011463
Bombyx mori
Silkmoth
Bmor\BGIBMGA008401
Bombyx mori
Silkmoth
Bmor\BGIBMGA008824
Bombyx mori
Silkmoth
Bmor\BGIBMGA009866
Danaus plexippus
Monarch butterfly
Dple\DPOGS200818-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210009-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200817-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215259-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209233-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215263-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215432-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016348
Heliconius melpomene
Postman butterfly
Hmel\HMEL010183
Heliconius melpomene
Postman butterfly
Hmel\HMEL016167
Heliconius melpomene
Postman butterfly
Hmel\HMEL017513
Heliconius melpomene
Postman butterfly
Hmel\HMEL013752
Heliconius melpomene
Postman butterfly
Hmel\HMEL013037
Apis florea
Little honeybee
Aflo\2322783764
Apis florea
Little honeybee
Aflo\2216906772
Apis florea
Little honeybee
Aflo\3446728468
Apis mellifera
Western honey bee
Amel\GB55499
Apis mellifera
Western honey bee
Amel\GB52063
Apis mellifera
Western honey bee
Amel\LOC410530
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20243
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19667
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16694
Bombus terrestris
Buff-tailed bumblebee
Bter\15206170
Bombus terrestris
Buff-tailed bumblebee
Bter\15213365
Bombus terrestris
Buff-tailed bumblebee
Bter\15214776
Linepithema humile
Argentine ant
Lhum\LH11167
Linepithema humile
Argentine ant
Lhum\LH20731
Linepithema humile
Argentine ant
Lhum\LH15311
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b20
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000a95
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001184
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001233
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004816
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07524
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04596
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01036
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02703
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05624
Tribolium castaneum
Red flour beetle
Tcas\TC032020
Tribolium castaneum
Red flour beetle
Tcas\TC034155
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07539
Pediculus humanus
Human body louse
Phum\PHUM193940
Pediculus humanus
Human body louse
Phum\PHUM129520
Pediculus humanus
Human body louse
Phum\PHUM251300
Pediculus humanus
Human body louse
Phum\PHUM129510
Rhodnius prolixus
Kissing bug
Rpro\RPRC001092
Rhodnius prolixus
Kissing bug
Rpro\RPRC014817
Rhodnius prolixus
Kissing bug
Rpro\RPRC001113
Rhodnius prolixus
Kissing bug
Rpro\RPRC009958
Rhodnius prolixus
Kissing bug
Rpro\RPRC006863
Cimex lectularius
Bed bug
Clec\CLEC003059
Cimex lectularius
Bed bug
Clec\CLEC008087
Cimex lectularius
Bed bug
Clec\CLEC004940
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009772
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007899
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI39787
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001572
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI063759
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006024
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004083
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006455
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11692
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01430
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11690
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05461
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05460
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06WR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007320
Ixodes scapularis
Black-legged tick
Isca\ISCW023785
Ixodes scapularis
Black-legged tick
Isca\ISCW000162
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57384.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58295.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59700.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56639.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70846.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58294.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g00330
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_251266
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_194087
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_269431
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_328304
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_228306
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_319945
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G067H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alpl_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016431gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016433gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alpl_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alpl
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alpi
Ciona intestinalis
Vase tunicate
Cint\LOC100175777
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021280
Ciona intestinalis
Vase tunicate
Cint\LOC100178630
Ciona intestinalis
Vase tunicate
Cint\ciap
Ciona intestinalis
Vase tunicate
Cint\LOC101243300
Ciona intestinalis
Vase tunicate
Cint\LOC100176308
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000023866
Gallus gallus
Domestic chicken
Ggal\LOC100859876
Gallus gallus
Domestic chicken
Ggal\ALPL
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (12)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Alp9
8 of 10
Alp1
7 of 10
Alp5
7 of 10
Alp6
7 of 10
Alp10
7 of 10
Alp11
7 of 10
Alp12
7 of 10
Alp2
6 of 10
Alp4
6 of 10
Alp7
6 of 10
Alp8
6 of 10
Alp13
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ALPG; alkaline phosphatase, germ cell
    12 of 15
    171810
        ALPI; alkaline phosphatase, intestinal
        12 of 15
        171740
            ALPL; alkaline phosphatase, biomineralization associated
            12 of 15
            171760
            ALPP; alkaline phosphatase, placental
            11 of 15
            171800
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Interactions Browser
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map

                3-48

                Cytogenetic map
                85D18-85D18
                Sequence location
                3R:9,494,801..9,496,723 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                85D18-85D18
                Limits computationally determined from genome sequence between P{PZ}ps10615&P{PZ}Ras85D06677 and P{EP}CG9393EP3122
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Experimentally Determined Recombination Data
                Location

                3-48

                (FlyBase, 2016)

                3-46.1

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (3)
                Genomic Clones (20)
                cDNA Clones (20)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: phu CG8147

                (Jha et al., 2016)
                Source for database merge of

                Source for merge of: BEST:LD38109 CG8147

                (FlyBase, 1996-)
                Additional comments

                Source for merge of BEST:LD38109 CG8147 was a shared cDNA ( date:030206 ).

                (FlyBase, 1996-)
                Other Comments

                Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.

                (Jha et al., 2016)

                Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Showed cycling in Canton S and low expression in Clk mutants in microarray experiments. Identified in S2/cycloheximide assay as a direct target of Clk mediated transcriptional regulation.

                (McDonald and Rosbash, 2001)
                Origin and Etymology
                Discoverer
                Etymology

                Named 'phurba tashi' after the legendary Sherpa mountaineer, as RNAi-mediated knockdown of this gene's expression significantly enhances survival in severe hypoxia.

                (Jha et al., 2016)
                Identification
                External Crossreferences and Linkouts ( 41 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DPiM - Drosophila Protein interaction map
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (8)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (69)