scaffolding protein involved in Hippo signaling pathway - cofactor of Yorkie - regulation of macroautophagy/autophagy-lysosomal-mediated degradation - genetically interacts with Parkin to modulate mitochondrial morphology - negatively regulates the recruitment of Parkin to mitochondria - negatively regulates the recruitment of Parkin to mitochondria - promotes autophagic flux by enhancing lysosomal function
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
May interact with Unc-89 (via protein kinase domain 1 or 2).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mask using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mask in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: mask CG18671 CG6268 CG6313
Source for merge of: mask CG18671 CG6268 CG6313
Annotations CG6268, CG6313, CG18671 merged as CG33106 in release 3 of the genome annotation.
Source for merge of mask CG18671 CG6268 CG6313 was sequence comparison ( date:020316 ).
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.
mask is crucial for photoreceptor differentiation, cell survival and cell proliferation.
Identification: as a modifier of the rough eye phenotype caused by expression of a dominant negative form of csw.
Homozygotes die during larval development.