FB2019_05, released Oct 15, 2019

Gene: Dmel\mask

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General Information
Symbol
Dmel\mask
Species
D. melanogaster
Name
multiple ankyrin repeats single KH domain
Annotation Symbol
CG33106
Feature Type
protein_coding_gene
FlyBase ID
FBgn0043884
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Key Links
Genomic Location
Cytogenetic map
95F3-95F5
Sequence location
3R:24,230,562..24,250,248 [+]
Recombination map
3-84
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein kinase binding
Predictions / Assertions
RNA binding
Summaries
Protein Function (UniProtKB)
Mediator of receptor tyrosine kinase (RTK) signaling, and may act either downstream of MAPK or transduce signaling through a parallel branch of the RTK pathway (PubMed:11782402). Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere (PubMed:26251439).
(UniProt, Q9VCA8)
Summary (Interactive Fly)
scaffolding protein involved in Hippo signaling pathway - cofactor of Yorkie - regulation of macroautophagy/autophagy-lysosomal-mediated degradation - genetically interacts with Parkin to modulate mitochondrial morphology - negatively regulates the recruitment of Parkin to mitochondria - negatively regulates the recruitment of Parkin to mitochondria - promotes autophagic flux by enhancing lysosomal function
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
5

Please see the GBrowse view of Dmel\mask or the JBrowse view of Dmel\mask for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mask-RA
FBtr0084562
NM_176556
14396
4001
mask-RB
FBtr0084563
NM_176557
13001
4001
mask-RC
FBtr0305043
NM_001260351
14423
4010
mask-RD
FBtr0334942
NM_001275974
13229
3636
mask-RE
FBtr0334943
NM_001275975
14393
4000
mask-RF
FBtr0345261
NM_001300571
13190
3623
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
mask-PA
FBpp0083947
423.2
4001
5.44
NP_788733
AAO41600
mask-PB
FBpp0083948
423.2
4001
5.44
NP_788734
AAO41601
mask-PC
FBpp0293580
424.2
4010
5.42
NP_001247280
AFH06598
mask-PD
FBpp0306960
388.3
3636
5.30
NP_001262903
AGB96283
mask-PE
FBpp0306961
423.1
4000
5.46
NP_001262904
AGB96284
mask-PF
FBpp0311438
386.8
3623
5.30
NP_001287500
AHN57499
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

4001 aa isoforms: mask-PA, mask-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
May interact with Unc-89 (via protein kinase domain 1 or 2).
(UniProt, Q9VCA8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mask using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (15 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
protein kinase binding
inferred from physical interaction with UniProtKB:A8DYP0
(assigned by UniProt )
(Katzemich et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
RNA binding
inferred from electronic annotation with InterPro:IPR004088
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
compound eye photoreceptor cell differentiation
inferred from mutant phenotype
(Smith et al., 2002)
flight
inferred from mutant phenotype
(assigned by UniProt )
(Katzemich et al., 2015)
mitochondrion organization
inferred from mutant phenotype
(Zhu et al., 2015)
negative regulation of apoptotic process
inferred from genetic interaction with FLYBASE:csw; FB:FBgn0000382
(Smith et al., 2002)
negative regulation of autophagy of mitochondrion
inferred from mutant phenotype
(Zhu et al., 2015)
inferred from genetic interaction with FLYBASE:Atg18a; FB:FBgn0035850
(Zhu et al., 2015)
regulation of establishment of blood-brain barrier
inferred from mutant phenotype
(Li et al., 2017)
sarcomere organization
inferred from mutant phenotype
(Katzemich et al., 2015)
transmembrane receptor protein tyrosine kinase signaling pathway
inferred from genetic interaction with FLYBASE:csw; FB:FBgn0000382
(Smith et al., 2002)
inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Smith et al., 2002)
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Smith et al., 2002)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
inferred from direct assay
(Smith et al., 2002)
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
M band
inferred from direct assay
(Katzemich et al., 2015)
nucleus
inferred from high throughput direct assay
(Sarov et al., 2016)
Z disc
inferred from direct assay
(Katzemich et al., 2015)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
inferred from direct assay
(Smith et al., 2002)
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
M band
inferred from direct assay
(Katzemich et al., 2015)
nucleus
inferred from high throughput direct assay
(Sarov et al., 2016)
Z disc
inferred from direct assay
(Katzemich et al., 2015)
Expression Deduced from Reporters
Reporter: PBac{754.P.FSVS-0}maskCPTI002830
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mask in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mask
Transgenic constructs containing regulatory region of mask
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage (with mask6.3)
lethal - all die before end of larval stage (with mask7.29)
lethal - all die before end of P-stage, with Scer\GAL4Mef2.PU
lethal - all die during pupal stage, with Scer\GAL4how-24B
partially lethal - majority die, with Scer\GAL4Mef2.PU
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
viable (with mask10.22)
viable (with maskEY13048)
Sterility
Allele
fertile
Other Phenotypes
Allele
body color defective, with Scer\GAL4pnr-MD237
decreased cell number | adult stage | somatic clone
decreased cell number | larval stage | somatic clone
flightless, with Scer\GAL4Mef2.PR
flightless, with Scer\GAL4Mef2.PU
increased cell death (with mask6.3)
increased cell death (with mask7.29)
increased cell death | larval stage, with Scer\GAL4repo.PU
increased cell death | larval stage | somatic clone
increased cell death | recessive | somatic clone
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
size defective | adult stage, with Scer\GAL4ey.PU
size defective | larval stage, with Scer\GAL4moody.PU
size defective | third instar larval stage
small body | larval stage (with mask6.3)
small body | larval stage (with mask7.29)
some die during larval stage (with mask6.3)
some die during larval stage (with mask7.29)
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4ey.PU
Phenotype manifest in
Allele
autolysosome | third instar larval stage, with Scer\GAL4how-24B
autophagosome | third instar larval stage, with Scer\GAL4how-24B
autophagosome | wandering third instar larval stage (with Df(3R)BSC317)
dorsal appendage | somatic clone
embryonic/larval brain | larval stage, with Scer\GAL4moody.PU
embryonic/larval brain | larval stage, with Scer\GAL4repo.PU
embryonic/larval CNS subperineurial glial cell | larval stage, with Scer\GAL4moody.PU
embryonic/larval digestive system (with mask6.3)
embryonic/larval digestive system (with mask7.29)
embryonic/larval somatic muscle | third instar larval stage, with Scer\GAL4how-24B
embryonic/larval somatic muscle | third instar larval stage (with Df(3R)BSC317)
embryonic/larval somatic muscle | wandering third instar larval stage (with Df(3R)BSC317)
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye-antennal disc (with mask6.3)
eye-antennal disc (with mask7.29)
eye-antennal disc | somatic clone
eye photoreceptor cell | somatic clone
indirect flight muscle | adult stage, with Scer\GAL4Mef2.PU
mesothoracic tergum, with Scer\GAL4pnr-MD237
mitochondrion | third instar larval stage, with Scer\GAL4how-24B
mitochondrion | third instar larval stage (with Df(3R)BSC317)
myofibril, with Scer\GAL4Mef2.PR
myofibril | adult stage, with Scer\GAL4Mef2.PU
ommatidial precursor cluster (with mask6.3)
ommatidial precursor cluster (with mask7.29)
ommatidial precursor cluster | somatic clone
perineurium | adult stage, with Scer\GAL4moody.PU
perineurium | larval stage, with Scer\GAL4moody.PU
photoreceptor cell | somatic clone
photoreceptor cell R1 | somatic clone
photoreceptor cell R6 | somatic clone
photoreceptor cell R7 | somatic clone
sarcomere | adult stage, with Scer\GAL4Mef2.PU
septate junction | larval stage, with Scer\GAL4moody.PU
trichogen cell, with Scer\GAL4pnr-MD237
Z disc | adult stage, with Scer\GAL4Mef2.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ANKRD17
9 of 15
Yes
Yes
Hsap\ANKHD1-EIF4EBP3
8 of 15
No
Yes
Hsap\ANKHD1
2 of 15
No
Yes
Hsap\EIF4EBP3
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ankrd17
8 of 15
Yes
Yes
Mmus\Ankhd1
6 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Ankhd1
7 of 13
Yes
Yes
Rnor\Ankrd17
5 of 13
No
Yes
Rnor\Ankrd50
1 of 13
No
No
Rnor\Anks6
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\ankhd1
3 of 12
Yes
Yes
Xtro\ankrd17
3 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\ankhd1
8 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\R11A8.7
9 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (5)
Atha\AT5G14230
1 of 9
Yes
Yes
Atha\SKOR
1 of 9
Yes
No
Atha\XBAT31
1 of 9
Yes
Yes
Atha\XBAT32
1 of 9
Yes
Yes
Atha\XBAT33
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\HOS4
2 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919009F )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\mask
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009269
Drosophila simulans
Dsim\GD21081
Drosophila sechellia
Dsec\GM26576
Drosophila erecta
Dere\GG11270
Drosophila yakuba
Dyak\GE23462
Drosophila ananassae
Dana\GF16118
Drosophila pseudoobscura pseudoobscura
Dpse\GA27251
Drosophila persimilis
Dper\GL23419
Drosophila willistoni
Dwil\GK11389
Drosophila virilis
Dvir\GJ10528
Drosophila mojavensis
Dmoj\GI24181
Drosophila grimshawi
Dgri\GH18670
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915003W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015471
Glossina morsitans
Tsetse fly
Gmor\GMOY002483
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06782
Mayetiola destructor
Hessian fly
Mdes\Mdes000810
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004651
Anopheles darlingi
American malaria mosquito
Adar\ADAC009824
Anopheles gambiae
Malaria mosquito
Agam\AGAP003519
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002710
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002709
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W002C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006328
Danaus plexippus
Monarch butterfly
Dple\DPOGS210715-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004668
Apis florea
Little honeybee
Aflo\2147487505
Apis florea
Little honeybee
Aflo\2147536947
Apis mellifera
Western honey bee
Amel\GB52985
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12842
Bombus terrestris
Buff-tailed bumblebee
Bter\15215942
Linepithema humile
Argentine ant
Lhum\LH23578
Linepithema humile
Argentine ant
Lhum\LH26053
Linepithema humile
Argentine ant
Lhum\LH23585
Linepithema humile
Argentine ant
Lhum\LH23583
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0007d6
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016792
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016823
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08104
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08106
Tribolium castaneum
Red flour beetle
Tcas\TC001033
Pediculus humanus
Human body louse
Phum\PHUM473040
Rhodnius prolixus
Kissing bug
Rpro\RPRC009738
Rhodnius prolixus
Kissing bug
Rpro\RPRC009737
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008142
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11163
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X014Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004638
Strigamia maritima
European centipede
Smar\SMAR013764
Ixodes scapularis
Black-legged tick
Isca\ISCW008360
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83143.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77049.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur20g00770
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04SM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ankhd1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ankrd17
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_021764gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006550
Gallus gallus
Domestic chicken
Ggal\ANKRD17
Gallus gallus
Domestic chicken
Ggal\ANKHD1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ank2
2 of 10
Ank
1 of 10
CG10011
1 of 10
CG42672
1 of 10
nompC
1 of 10
Tnks
1 of 10
TrpA1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 4 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
     
    park[25]/park[Δ21] transheterozygotes were used as the disease model.
    (Zhu et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ANKRD17; ankyrin repeat domain 17
    9 of 15
    615929
        ANKHD1-EIF4EBP3; ANKHD1-EIF4EBP3 readthrough
        8 of 15
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            RNA-RNA
            Physical Interaction
            Assay
            References
            mask - mir-285
            luminiscence technology, necessary binding region
            (Li et al., 2017)
            protein-protein
            Physical Interaction
            Assay
            References
            mask - Myc
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            mask - Pdk1
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            mask - Pi3K21B
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            mask - Rheb
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            mask - S6kII
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            mask - Tsc1
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            mask - Unc-89
            pull down, anti tag western blot, two hybrid
            (Katzemich et al., 2015)
            mask - dome
            anti tag coimmunoprecipitation, anti tag western blot
            (Fisher et al., 2018)
            mask - gig
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            mask - rictor
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            mask - yki
            anti tag coimmunoprecipitation, anti tag western blot
            (Sansores-Garcia et al., 2013, Sidor et al., 2013)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            mask|park
            suppressible
            Atg18a
            (Zhu et al., 2015)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Atg1
            enhanceable
            mask
            (Zhu et al., 2017)
            csw::Src64B
            suppressible
            mask
            (Smith et al., 2002)
            csw
            enhanceable
            mask
            (Smith et al., 2002)
            mir-285
            suppressible
            mask
            (Li et al., 2017)
            park
            suppressible
            mask
            (Zhu et al., 2015)
            park
            enhanceable
            mask
            (Zhu et al., 2015)
            Pink1
            suppressible
            mask
            (Zhu et al., 2015)
            Prosβ6
            suppressible
            mask
            (Zhu et al., 2017)
            Prosβ6
            enhanceable
            mask
            (Zhu et al., 2017)
            Prosβ6
            suppressible
            Atg1|mask
            (Zhu et al., 2017)
            Prosβ6
            suppressible
            Vha68-2|mask
            (Zhu et al., 2017)
            Prosβ6
            suppressible
            Atg2|mask
            (Zhu et al., 2017)
            Prosβ6
            suppressible
            Atg18a|mask
            (Zhu et al., 2017)
            Ras85D
            suppressible
            mask
            (Smith et al., 2002)
            Ras85D
            enhanceable
            mask
            (Smith et al., 2002)
            rl
            suppressible
            mask
            (Smith et al., 2002)
            sev
            suppressible
            mask
            (Smith et al., 2002)
            External Data
            Subunit Structure (UniProtKB)
            May interact with Unc-89 (via protein kinase domain 1 or 2).
            (UniProt, Q9VCA8 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            External Data
            Linkouts
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-84
            Cytogenetic map
            95F3-95F5
            Sequence location
            3R:24,230,562..24,250,248 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            95F3-95F5
            Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            95E-95F
            (Smith, 2001.9.27)
            Experimentally Determined Recombination Data
            Location
            3-84
            (FlyBase, 2016)
            3-82.8
            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (16)
            Genomic Clones (21)
            cDNA Clones (117)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            monoclonal
            (Na et al., 2016)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for identity of: mask CG18671 CG6268 CG6313
            (Smith et al., 2002)
            Source for database merge of
            Source for merge of: mask CG18671 CG6268 CG6313
            (FlyBase, 1996-)
            Additional comments
            scaRNA:mgU2-25 is encoded in an intron of mask.
            (Graveley et al., 2011)
            Annotations CG6268, CG6313, CG18671 merged as CG33106 in release 3 of the genome annotation.
            (FlyBase Genome Annotators, 2002-2003)
            Source for merge of mask CG18671 CG6268 CG6313 was sequence comparison ( date:020316 ).
            (FlyBase, 1996-)
            Other Comments
            RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.
            (Kleino et al., 2005)
            mask is crucial for photoreceptor differentiation, cell survival and cell proliferation.
            (Smith et al., 2002)
            Identification: as a modifier of the rough eye phenotype caused by expression of a dominant negative form of csw.
            (Smith et al., 2001)
            mask has a role in cell proliferation and prevention of programmed cell death.
            (Smith et al., 2001)
            Homozygotes die during larval development.
            (Smith et al., 2001)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 72 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (11)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (98)