FlyBase Gene Report: Dmel\mask

General Information

Symbol

Dmel\mask

Species

D. melanogaster

Name

multiple ankyrin repeats single KH domain

Annotation Symbol

CG33106

Feature Type

protein_coding_gene

FlyBase ID

FBgn0043884

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Mediator of receptor tyrosine kinase (RTK) signaling, and may act either downstream of MAPK or transduce signaling through a parallel branch of the RTK pathway (PubMed:11782402). Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere (PubMed:26251439). (UniProt, Q9VCA8)

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All Summaries

Alliance
Auto summary
Pathway
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

95F3-95F5

Sequence location

3R:24,230,562..24,250,248 [+]

Recombination map

3-84

RefSeq locus

NT_033777 REGION:24230562..24250248

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (19 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein kinase binding

inferred from physical interaction with UniProtKB:A8DYP0

(assigned by UniProt )

(Katzemich et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables RNA binding

inferred from electronic annotation with InterPro:IPR004088

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (11 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

involved_in compound eye photoreceptor cell differentiation

inferred from mutant phenotype

(Smith et al., 2002)

involved_in dorsal appendage formation

inferred from mutant phenotype

(Smith et al., 2002)

involved_in flight

inferred from mutant phenotype

(assigned by UniProt )

(Katzemich et al., 2015)

involved_in mitochondrion organization

inferred from mutant phenotype

(Zhu et al., 2015)

involved_in negative regulation of autophagy of mitochondrion

inferred from mutant phenotype

(Zhu et al., 2015)

inferred from genetic interaction with FLYBASE:Atg18a; FB:FBgn0035850

(Zhu et al., 2015)

involved_in negative regulation of establishment of blood-brain barrier

inferred from mutant phenotype

(Li et al., 2017)

involved_in positive regulation of receptor signaling pathway via JAK-STAT

inferred from genetic interaction with FLYBASE:dome; FB:FBgn0043903

(Fisher et al., 2018)

involved_in positive regulation of sevenless signaling pathway

inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366

(Smith et al., 2002)

involved_in positive regulation of transcription by RNA polymerase II

inferred from genetic interaction with FLYBASE:yki; FB:FBgn0034970

(Sansores-Garcia et al., 2013, Sidor et al., 2013)

involved_in sarcomere organization

inferred from mutant phenotype

(Katzemich et al., 2015)

involved_in transmembrane receptor protein tyrosine kinase signaling pathway

inferred from genetic interaction with FLYBASE:csw; FB:FBgn0000382

(Smith et al., 2002)

inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205

(Smith et al., 2002)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from high throughput direct assay

(Sarov et al., 2016)

located_in cytosol

inferred from direct assay

(Smith et al., 2002)

inferred from high throughput direct assay

(Lye et al., 2014)

located_in M band

inferred from direct assay

(Katzemich et al., 2015)

located_in nucleus

inferred from high throughput direct assay

(Sarov et al., 2016)

part_of RNA polymerase II transcription regulator complex

inferred from physical interaction with FLYBASE:sd; FB:FBgn0003345, FLYBASE:yki; FB:FBgn0034970

(Sidor et al., 2013)

located_in Z disc

inferred from direct assay

(Katzemich et al., 2015)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Pathway (FlyBase)

Positive Regulators of Sevenless Signaling Pathway

Positive Regulators of JAK-STAT Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

Positive Regulators of Sevenless Signaling Pathway -: Positive regulators of Sevenless signaling up-regulate the pathway, promoting cell fate to that of an R7 photoreceptor. (Adapted from FBrf0127283 and FBrf0221727).
Positive Regulators of JAK-STAT Signaling Pathway -: Positive regulators of JAK-STAT signaling up-regulate the pathway, enhancing transcriptional control by Stat92E.

Protein Function (UniProtKB)

(UniProt, Q9VCA8)

Summary (Interactive Fly)

scaffolding protein involved in Hippo signaling pathway - cofactor of Yorkie - regulation of macroautophagy/autophagy-lysosomal-mediated degradation - genetically interacts with Parkin to modulate mitochondrial morphology - negatively regulates the recruitment of Parkin to mitochondria - negatively regulates the recruitment of Parkin to mitochondria - promotes autophagic flux by enhancing lysosomal function

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mask for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VCA8)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mask-RA

FBtr0084562

NM_176556

14396

4001

mask-RB

FBtr0084563

NM_176557

13001

4001

mask-RC

FBtr0305043

NM_001260351

14423

4010

mask-RD

FBtr0334942

NM_001275974

13229

3636

mask-RE

FBtr0334943

NM_001275975

14393

4000

mask-RF

FBtr0345261

NM_001300571

13190

3623

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

mask-PA

FBpp0083947

423.2

4001

5.44

NP_788733

AAO41600

mask-PB

FBpp0083948

423.2

4001

5.44

NP_788734

AAO41601

mask-PC

FBpp0293580

424.2

4010

5.42

NP_001247280

AFH06598

mask-PD

FBpp0306960

388.3

3636

5.30

NP_001262903

AGB96283

mask-PE

FBpp0306961

423.1

4000

5.46

NP_001262904

AGB96284

mask-PF

FBpp0311438

386.8

3623

5.30

NP_001287500

AHN57499

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

4001 aa isoforms: mask-PA, mask-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

May interact with Unc-89 (via protein kinase domain 1 or 2).

(UniProt, Q9VCA8)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mask using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from high throughput direct assay

(Sarov et al., 2016)

located_in cytosol

inferred from direct assay

(Smith et al., 2002)

inferred from high throughput direct assay

(Lye et al., 2014)

located_in M band

inferred from direct assay

(Katzemich et al., 2015)

located_in nucleus

inferred from high throughput direct assay

(Sarov et al., 2016)

part_of RNA polymerase II transcription regulator complex

inferred from physical interaction with FLYBASE:sd; FB:FBgn0003345, FLYBASE:yki; FB:FBgn0034970

(Sidor et al., 2013)

located_in Z disc

inferred from direct assay

(Katzemich et al., 2015)

Expression Deduced from Reporters

Reporter: PBac{754.P.FSVS-0}mask^CPTI002830

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mask in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mask

View exonic expression by tissue for Dmel\mask

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0043884

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

50070/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0043884

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0043884

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0043884

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33106

Flygut - An atlas of the Drosophila adult midgut

FBgn0043884

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\mask

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 23 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mask

Transgenic constructs containing regulatory region of mask

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6198

(Ryder, 2004.4.26)

Gene not disrupted in

Df(3R)jar³²²

(Petritsch et al., 2003)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage (with mask^6.3)

mask^7.29

lethal - all die before end of larval stage (with mask^7.29)

mask^6.3

lethal - all die before end of P-stage, with Scer\GAL4^Mef2.PU

mask^KK100529

lethal - all die during pupal stage, with Scer\GAL4^how-24B

partially lethal - majority die, with Scer\GAL4^Mef2.PU

mask^GD9632

partially lethal - majority die, with Scer\GAL4^pnr-MD237

mask^GD9632

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

mask^GD9632

viable, with Scer\GAL4^Mef2.PR

mask^GD9632

viable, with Scer\GAL4^tin.CΔ4

mask^GD9632

viable (with mask^10.22)

mask^EY13048

viable (with mask^EY13048)

mask^10.22

Sterility

Allele

fertile

mask^EY08185

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

mask^GD9632

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

mask^GD9632

abnormal size | adult stage, with Scer\GAL4^ey.PU

mask^HMS01045

abnormal size | larval stage, with Scer\GAL4^moody.PU

mask^HMS01045

abnormal size | third instar larval stage

mask^UAS.cZa

decreased body size | larval stage (with mask^6.3)

mask^7.29

decreased body size | larval stage (with mask^7.29)

mask^6.3

decreased cell number | adult stage | somatic clone

mask^10.22

decreased cell number | larval stage | somatic clone

mask^10.22

flightless, with Scer\GAL4^Mef2.PR

mask^GD9632

flightless, with Scer\GAL4^Mef2.PU

increased cell death (with mask^6.3)

mask^7.29

increased cell death (with mask^7.29)

mask^6.3

increased cell death | larval stage, with Scer\GAL4^repo.PU

mask^HMS01045

increased cell death | larval stage | somatic clone

mask^10.22

increased cell death | recessive | somatic clone

mask^10.22

some die during larval stage (with mask^6.3)

mask^7.29

some die during larval stage (with mask^7.29)

mask^6.3

some die during pupal stage, with Scer\GAL4^pnr-MD237

mask^GD9632

visible, with Scer\GAL4^ey.PH

mask^EP601

visible, with Scer\GAL4^pnr-MD237

mask^GD9632

visible | adult stage, with Scer\GAL4^ey.PU

mask^HMS01045

Phenotype manifest in

Allele

autolysosome | third instar larval stage, with Scer\GAL4^how-24B

autophagosome | third instar larval stage, with Scer\GAL4^how-24B

autophagosome | wandering third instar larval stage (with Df(3R)BSC317)

mask^10.22

dorsal appendage | somatic clone

mask^10.22

embryonic/larval brain | larval stage, with Scer\GAL4^moody.PU

mask^HMS01045

embryonic/larval brain | larval stage, with Scer\GAL4^repo.PU

mask^HMS01045

embryonic/larval CNS subperineurial glial cell | larval stage, with Scer\GAL4^moody.PU

mask^HMS01045

embryonic/larval digestive system (with mask^6.3)

mask^7.29

embryonic/larval digestive system (with mask^7.29)

mask^6.3

embryonic/larval somatic muscle cell | third instar larval stage, with Scer\GAL4^how-24B

embryonic/larval somatic muscle cell | third instar larval stage (with Df(3R)BSC317)

mask^10.22

embryonic/larval somatic muscle cell | wandering third instar larval stage (with Df(3R)BSC317)

mask^10.22

eye, with Scer\GAL4^ey.PH

mask^EP601

eye, with Scer\GAL4^ey.PU

mask^HMS01045

eye-antennal disc (with mask^6.3)

mask^7.29

eye-antennal disc (with mask^7.29)

mask^6.3

eye-antennal disc | somatic clone

mask^10.22

eye photoreceptor cell | somatic clone

mask^10.22

indirect flight muscle cell | adult stage, with Scer\GAL4^Mef2.PU

mesothoracic tergum, with Scer\GAL4^pnr-MD237

mask^GD9632

mitochondrion | third instar larval stage, with Scer\GAL4^how-24B

mitochondrion | third instar larval stage (with Df(3R)BSC317)

mask^10.22

myofibril, with Scer\GAL4^Mef2.PR

mask^GD9632

myofibril | adult stage, with Scer\GAL4^Mef2.PU

ommatidial precursor cluster (with mask^6.3)

mask^7.29

ommatidial precursor cluster (with mask^7.29)

mask^6.3

ommatidial precursor cluster | somatic clone

mask^10.22

perineurium | adult stage, with Scer\GAL4^moody.PU

mask^HMS01045

perineurium | larval stage, with Scer\GAL4^moody.PU

mask^HMS01045

photoreceptor cell R1 | somatic clone

mask^10.22

photoreceptor cell R6 | somatic clone

mask^10.22

photoreceptor cell R7 | somatic clone

photoreceptor neuron | somatic clone

sarcomere | adult stage, with Scer\GAL4^Mef2.PU

septate junction | larval stage, with Scer\GAL4^moody.PU

mask^HMS01045

trichogen cell, with Scer\GAL4^pnr-MD237

mask^GD9632

Z disc | adult stage, with Scer\GAL4^Mef2.PU

mask^GD9632

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ANKRD17

10 of 15

Yes

Hsap\ANKHD1-EIF4EBP3

9 of 15

Yes

Hsap\ANKHD1

2 of 15

Yes

Hsap\ANKRD55

2 of 15

Yes

Hsap\ANKFY1

1 of 15

Hsap\ANKRD22

1 of 15

Yes

Hsap\ANKRD28

1 of 15

Hsap\ANKRD42

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ankrd17

9 of 15

Yes

Mmus\Ankhd1

8 of 15

Yes

Mmus\Ankrd55

2 of 15

Yes

Mmus\Ankfy1

1 of 15

Mmus\Ankrd22

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (15)

Rnor\Ankhd1

6 of 13

Yes

Rnor\Ankrd17

6 of 13

Yes

Rnor\Ankrd55

2 of 13

Yes

Rnor\Ankfy1

1 of 13

Rnor\Ankrd22

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Tonsl

1 of 13

Xenopus tropicalis (Western clawed frog) (15)

Xtro\ankhd1

4 of 12

Yes

Xtro\ankrd17

4 of 12

Yes

Xtro\ankfy1

1 of 12

Xtro\ankrd28

1 of 12

Yes

Xtro\ankrd42

1 of 12

Yes

Xtro\ankrd52

1 of 12

Yes

Xtro\ankrd55

1 of 12

Yes

Xtro\LOC100490559

1 of 12

Yes

Xtro\LOC100492885

1 of 12

Xtro\LOC101732603

1 of 12

Yes

Xtro\LOC101735265

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (20)

Drer\ankhd1

9 of 15

Yes

Drer\ankrd55

2 of 15

Yes

Drer\LOC100535451

2 of 15

Yes

Drer\ank1b

1 of 15

Drer\ankfy1

1 of 15

Drer\ankrd22

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\nfkbiaa

1 of 15

Drer\nfkbiab

1 of 15

Drer\pla2g6

1 of 15

Drer\si:cabz01054396.2

1 of 15

Drer\si:ch211-1o7.2

1 of 15

Yes

Drer\si:ch1073-398c20.3

1 of 15

Yes

Drer\tonsl

1 of 15

Drer\trpn1

1 of 15

Drer\znf1160

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\mask-1

10 of 15

Yes

Cele\F22G12.4

1 of 15

Cele\trp-4

1 of 15

Arabidopsis thaliana (thale-cress) (9)

Atha\AT2G03430

1 of 9

Yes

Atha\AT4G32250

1 of 9

Yes

Atha\AT5G14230

1 of 9

Yes

Atha\KEG

1 of 9

Yes

Atha\SKOR

1 of 9

Yes

Atha\TPR10

1 of 9

Yes

Atha\XBAT31

1 of 9

Yes

Atha\XBAT32

1 of 9

Yes

Atha\XBAT33

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\HOS4

3 of 15

Yes

Scer\GLN3

1 of 15

Scer\NAS6

1 of 15

Scer\PHO81

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC6C3.08

1 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (9)

Gene Symbol

Score

Source

Alignment

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

mask^HMS01045

ameliorates Parkinson's disease

modeled by park²⁵, park^Δ21

(Zhu et al., 2015)

modeled by Pink1^B9

(Zhu et al., 2015)

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.GFP

(Zhu et al., 2017)

exacerbates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R521H.UAS.Tag:HA}

(Zhu et al., 2017)

mask^10.22

ameliorates Parkinson's disease

modeled by park²⁵, park^Δ21

(Zhu et al., 2015)

modeled by Pink1^B9

(Zhu et al., 2015)

mask^KK100529

ameliorates Parkinson's disease

modeled by Pink1^B9

(Zhu et al., 2015)

mask^EY13048

ameliorates Parkinson's disease

modeled by park²⁵, park^Δ21

(Zhu et al., 2015)

modeled by Pink1^B9

(Zhu et al., 2015)

mask^UAS.cZa

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.GFP

(Zhu et al., 2017)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R521H.UAS.Tag:HA}

(Zhu et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ANKRD17; ankyrin repeat domain 17

10 of 15

615929

CHOPRA-AMIEL-GORDON SYNDROME; CAGS

ANKHD1-EIF4EBP3; ANKHD1-EIF4EBP3 readthrough

9 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

mask - mir-285

luminiscence technology, necessary binding region

(Li et al., 2017)

protein-protein

Physical Interaction

Assay

References

mask - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

mask - Pdk1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

mask - Pi3K21B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

mask - Rheb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

mask - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

mask - Tsc1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

mask - Unc-89

two hybrid, pull down, anti tag western blot

(Katzemich et al., 2015)

mask - dome

anti tag coimmunoprecipitation, anti tag western blot

(Fisher et al., 2018)

mask - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

mask - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

mask - yki

anti tag coimmunoprecipitation, anti tag western blot

(Sansores-Garcia et al., 2013, Sidor et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mask|park

suppressible

Atg18a

(Zhu et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Zhu et al., 2017)

suppressible

(Smith et al., 2002)

csw

enhanceable

mask

(Smith et al., 2002)

suppressible

(Li et al., 2017)

suppressible

(Zhu et al., 2015)

enhanceable

(Zhu et al., 2015)

suppressible

(Zhu et al., 2015)

suppressible

(Zhu et al., 2017)

suppressible

(Zhu et al., 2017)

suppressible

(Zhu et al., 2017)

suppressible

(Zhu et al., 2017)

suppressible

(Zhu et al., 2017)

enhanceable

(Zhu et al., 2017)

enhanceable

(Smith et al., 2002)

Ras85D

suppressible

mask

(Smith et al., 2002)

suppressible

mask

(Smith et al., 2002)

sev

suppressible

mask

(Smith et al., 2002)

External Data

Subunit Structure (UniProtKB)

May interact with Unc-89 (via protein kinase domain 1 or 2).

(UniProt, Q9VCA8 )

Linkouts

BioGRID - A database of protein and genetic interactions.

72524

DroID - A comprehensive database of gene and protein interactions.

FBgn0043884

MIST (genetic) - An integrated Molecular Interaction Database

mask

MIST (protein-protein) - An integrated Molecular Interaction Database

mask

Pathways

Signaling Pathways (FlyBase)

Positive Regulators of Sevenless Signaling Pathway -: Positive regulators of Sevenless signaling up-regulate the pathway, promoting cell fate to that of an R7 photoreceptor. (Adapted from FBrf0127283 and FBrf0221727).
Positive Regulators of JAK-STAT Signaling Pathway -: Positive regulators of JAK-STAT signaling up-regulate the pathway, enhancing transcriptional control by Stat92E.

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-84

Cytogenetic map

95F3-95F5

Sequence location

3R:24,230,562..24,250,248 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

95F3-95F5

Limits computationally determined from genome sequence between P{PZ}Syx1A⁰⁶⁷³⁷&P{PZ}Syx1A¹⁰⁶⁶⁰ and P{PZ}crb⁰⁷²⁰⁷&P{PZ}BRWD3⁰⁵⁸⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

95E-95F

(Smith, 2001.9.27)

Experimentally Determined Recombination Data

Location

3-84

(FlyBase, 2016)

3-82.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

51547

w^*; P{PTT-GC}mask^CC00924

31574

y¹ v¹; P{TRiP.JF01147}attP2

15910

y¹ w^67c23; P{EPgy2}mask^EY03656

17438

y¹ w^67c23; P{EPgy2}mask^EY08185

20853

y¹ w^67c23; P{EPgy2}mask^EY13048

62817

w¹¹¹⁸; PBac{IT.GAL4}mask^0380-G4/TM6B, Tb¹

34571

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01045}attP2

Kyoto

126063

w¹¹¹⁸; P{RS5}mask^5-SZ-3443

115338

w¹¹¹⁸; PBac{754.P.FSVS-0}mask^CPTI002830

VDRC

v103411

P{KK100529}VIE-260B

v33394

w¹¹¹⁸; P{GD9632}v33394

v318123

PBac{fTRG00486.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (117)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT12889

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0043884

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0043884

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

50070

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Na et al., 2016)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: mask CG18671 CG6268 CG6313

(Smith et al., 2002)

Source for database merge of

Source for merge of: mask CG18671 CG6268 CG6313

(FlyBase, 1996-)

Additional comments

scaRNA:mgU2-25 is encoded in an intron of mask.

(Graveley et al., 2011)

Annotations CG6268, CG6313, CG18671 merged as CG33106 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of mask CG18671 CG6268 CG6313 was sequence comparison ( date:020316 ).

(FlyBase, 1996-)

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.

(Kleino et al., 2005)

mask is crucial for photoreceptor differentiation, cell survival and cell proliferation.

(Smith et al., 2002)

Identification: as a modifier of the rough eye phenotype caused by expression of a dominant negative form of csw.

(Smith et al., 2001)

mask has a role in cell proliferation and prevention of programmed cell death.

(Smith et al., 2001)

Homozygotes die during larval development.

(Smith et al., 2001)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 76 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

50070

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VCA8

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VCA8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VCA8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0043884

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0043884

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

50070/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0043884

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0043884

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0043884

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33106

Flygut - An atlas of the Drosophila adult midgut

FBgn0043884

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

50070

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001033

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG33106

MARRVEL_MODEL - MARRVEL (model organism gene)

50070

modMine - A data warehouse for the modENCODE project

FBgn0043884

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VCA8

Linkouts

BioGRID - A database of protein and genetic interactions.

72524

DroID - A comprehensive database of gene and protein interactions.

FBgn0043884

DRSC - Results frm RNAi screens

FBgn0043884

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0043884

FlyMine - An integrated database for Drosophila genomics

FBgn0043884

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

mask

MIST (protein-protein) - An integrated Molecular Interaction Database

mask

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG18671

CG31138

(Petritsch et al., 2003)

CG33106

(Çiçek et al., 2016, Na et al., 2016, Brooks et al., 2015, Hosono et al., 2015, Müller et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Derré et al., 2007, Cermelli et al., 2006)

CG6268

(Kim et al., 2004, Tseng and Hariharan, 2002)

CG6313

(Anantharaman et al., 2002)

EC3-6

(Baril et al., 2014)

MASK

(Fisher et al., 2018, Manring et al., 2017, Katzemich et al., 2015, Enderle and McNeill, 2013, Fukuyama et al., 2013, Butchar et al., 2012)

Mask

(Johnson, 2021, Fulford et al., 2018, Zhu et al., 2017, Wang et al., 2016, Irvine and Harvey, 2015, Berg et al., 2012, Kallappagoudar et al., 2010)

cg6313

(Lasko, 2000)

Name Synonyms

multiple ankyrin repeats single KH domain

(Fukuyama et al., 2013, Cermelli et al., 2006, Smith et al., 2001)

Secondary FlyBase IDs

FBgn0039173
FBgn0039174
FBgn0040597
FBgn0051138

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (108)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections