nuclear PHD-finger protein - a core component of the Wingless signaling pathway that acts downstream of or at the level of Pangolin - a complex of Armadillo, Legless, and Pygopus coactivates dTCF to activate Wingless target genes
Gene model reviewed during 5.44
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear ARM/PAN complex.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pygo using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\pygo in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: pygo gam
dsRNA made from templates generated with primers directed against this gene.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of pygo causes a reduction in the arborization of ddaD and ddaE neurons. There is a severe reduction in primary branch outgrowth, lateral branching and lateral branch length. Additionally, there is also inappropriate dendritic routing of ddaE neurons.
pygo is necessary for apoptosis of excess photoreceptors at the periphery of the developing eye during pupal stages.
Null mutations have been isolated that affect the epidermis, denticle belts, antenna, legs and wings and are recessive viable.
A pygopus is a legless lizard with scaly skin.