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Gene Dmel\dome

General Information
Symbol	Dmel\dome	Species	D. melanogaster
Name	domeless	Annotation symbol	CG14226
Feature type	protein_coding_gene	FlyBase ID	FBgn0043903
Gene Model Status	Current	Stock availability	27 publicly available
Also Known As	vsp, mom
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	18D13-18E1	Sequence location	X:19,570,090..19,577,549 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene domeless is referred to in FlyBase by the symbol Dmel\dome (CG14226, FBgn0043903). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transmembrane signaling receptor activity; protein heterodimerization activity. There is experimental evidence that it is involved in the biological process: blastoderm segmentation; morphogenesis of an epithelium; hindgut morphogenesis; border follicle cell migration; positive regulation of cell proliferation; long-term memory; JAK-STAT cascade; open tracheal system development; compound eye morphogenesis. 49 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; multicellular structure; spiracle; integumentary specialisation; portion of tissue; adult segment; non-connected developing system; embryonic hindgut; epithelial cell; external compound sense organ. It has one annotated transcript and one annotated polypeptide. Protein features are: Fibronectin, type III; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632381_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dome. Gene sequence location is X:19570090..19577549.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466
FB2012_01	References Gao et al., 2011, genesis 49(3): 105--116 Makki et al., 2010, PLoS Biol. 8(8): e1000441 Sequence features BKN60078 BKN60227 HFA19583 BKN25660 Controlled Vocabulary Terms protein heterodimerization activity
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 18D13-18E1   Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
Experimentally Determined Cytological Location
Cytogenetic map Notes References 18E-18F   (determined by in situ hybridisation) 18E (determined by in situ hybridisation) 18E1--2 (determined by in situ hybridisation)   (Peter et al., 2002) 18E-18E   (determined by in situ hybridisation) 18E1--2 (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 18E-18F   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15)
Experimentally Determined Recombination Data
Location	1- (Castelli-Gair et al., 2001)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dome for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dome-RA FBtr0074756  NM_078688   4877   1282
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dome-PA   FBpp0074525   142.4   1282   6.53     NP_523412   AAF49002
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Fibronectin, type III (IPR003961) Immunoglobulin-like fold (IPR013783)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141247   AA141248   AA201546   AA538827   AA695325   AA803561   AA803593   AA820417   AA949594   AA951780   AA951941   AE014298 AAF49002   AI455416   AI456459   AI512020   AI515110   AI518671   AI546125   AJ420377 CAD12503   AW943869   AY075427 AAL68243   AY147847 AAN64333   BF490569   BF500775   BG637595   BG637599   BG639826   BH901033   BH901034   BI162983   BI166532   BI168681   BI170148   BI173339   BI212962   BI234238   BI234261   BI363376   BI364129   BI364959   BI373885   BI484590   CO178490   CO189752   CO267443   CO272094   CO273307   CO273662   CO279520   CO286500   CO292939   CO303029   CO309633   CO312742   CO314637   CO315000   CO315048   CO318270   CO322479   CO328773   CZ476744   EC054739   EC077321   EC079843   EC083684   EC195834   EC197987   EC202945   EC203022   EC204313   EC208529   EC213274   EC214105   EC214308   EC215079   EC220842   EC222041   EC222673   EC223461   EC232317   EC235645   EC236937   EC248376   EV576121   U85028   U85029
UniProtKB/Swiss-Prot	Q9VWE0
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Brown et al., 2001) Comment:transcript is maternally supplied embryonic stage 4 -- 17   organism | faint & ubiquitous   (Brown et al., 2001) embryonic stage 11   tracheal pit   (Brown et al., 2001) embryonic stage 14   organism | ubiquitous   (Hombria et al., 2005) pharynx   (Hombria et al., 2005) hindgut | anterior   (Hombria et al., 2005) posterior spiracle primordium   (Hombria et al., 2005, Brown et al., 2001) embryonic hindgut   (Brown et al., 2001) embryonic/larval pharynx   (Brown et al., 2001) presumptive embryonic/larval central nervous system   (Brown et al., 2001)
Additional Descriptive Data
	dome expression at embryonic stage 14 is ubiquitous, but more pronounced in the pharynx, the anterior hindgut, and the posterior spiracles. (Hombria et al., 2005)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0043903    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0043903 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0043903 expression level Developmental Stage   Expression Level embryo 00-02hr    7909 embryo 02-04hr    13442 embryo 04-06hr    10496 embryo 06-08hr    9352 embryo 08-10hr    6243 embryo 10-12hr    4138 embryo 12-14hr    2955 embryo 14-16hr    4204 embryo 16-18hr    2767 embryo 18-20hr    2554 embryo 20-22hr    4802 embryo 22-24hr    3114 larva L1    1188 larva L2    763 larva L3 12hr old    738 larva L3 puffstage 1-2    813 larva L3 puffstage 3-6    1531 larva L3 puffstage 7-9    1621 white prepupae new    2018 white prepupae 12hr    2132 white prepupae 24hr    2721 pupae 2d postWPP    1498 pupae 3d postWPP    739 pupae 4d postWPP    1305 adult male 01day    1000 adult male 05day    1385 adult male 30day    1599 adult female 01day    2786 adult female 05day    3360 adult female 30day    3773 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7909) embryo 02-04hr  (13442) embryo 04-06hr  (10496) embryo 06-08hr  (9352) embryo 08-10hr  (6243) embryo 10-12hr  (4138) embryo 12-14hr  (2955) embryo 14-16hr  (4204) embryo 16-18hr  (2767) embryo 18-20hr  (2554) embryo 20-22hr  (4802) embryo 22-24hr  (3114) larva L1  (1188) larva L2  (763) larva L3 12hr old  (738) larva L3 puffstage 1-2  (813) larva L3 puffstage 3-6  (1531) larva L3 puffstage 7-9  (1621) white prepupae new  (2018) white prepupae 12hr  (2132) white prepupae 24hr  (2721) pupae 2d postWPP  (1498) pupae 3d postWPP  (739) pupae 4d postWPP  (1305) adult male 01day  (1000) adult male 05day  (1385) adult male 30day  (1599) adult female 01day  (2786) adult female 05day  (3360) adult female 30day  (3773) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7909) embryo 02-04hr  (13442) embryo 04-06hr  (10496) embryo 06-08hr  (9352) embryo 08-10hr  (6243) embryo 10-12hr  (4138) embryo 12-14hr  (2955) embryo 14-16hr  (4204) embryo 16-18hr  (2767) embryo 18-20hr  (2554) embryo 20-22hr  (4802) embryo 22-24hr  (3114) larva L1    1188 larva L2    763 larva L3 12hr old    738 larva L3 puffstage 1-2    813 larva L3 puffstage 3-6  (1531) larva L3 puffstage 7-9  (1621) white prepupae new  (2018) white prepupae 12hr  (2132) white prepupae 24hr  (2721) pupae 2d postWPP  1498 pupae 3d postWPP    739 pupae 4d postWPP    1305 adult male 01day    1000 adult male 05day    1385 adult male 30day  (1599) adult female 01day  (2786) adult female 05day  (3360) adult female 30day  (3773) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7909 embryo 02-04hr  (13442) embryo 04-06hr  10496 embryo 06-08hr    9352 embryo 08-10hr    6243 embryo 10-12hr    4138 embryo 12-14hr    2955 embryo 14-16hr    4204 embryo 16-18hr    2767 embryo 18-20hr    2554 embryo 20-22hr    4802 embryo 22-24hr    3114 larva L1    1188 larva L2    763 larva L3 12hr old    738 larva L3 puffstage 1-2    813 larva L3 puffstage 3-6    1531 larva L3 puffstage 7-9    1621 white prepupae new    2018 white prepupae 12hr    2132 white prepupae 24hr    2721 pupae 2d postWPP    1498 pupae 3d postWPP    739 pupae 4d postWPP    1305 adult male 01day    1000 adult male 05day    1385 adult male 30day    1599 adult female 01day    2786 adult female 05day    3360 adult female 30day    3773 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7909 embryo 02-04hr    13442 embryo 04-06hr    10496 embryo 06-08hr    9352 embryo 08-10hr    6243 embryo 10-12hr    4138 embryo 12-14hr    2955 embryo 14-16hr    4204 embryo 16-18hr    2767 embryo 18-20hr    2554 embryo 20-22hr    4802 embryo 22-24hr    3114 larva L1    1188 larva L2    763 larva L3 12hr old    738 larva L3 puffstage 1-2    813 larva L3 puffstage 3-6    1531 larva L3 puffstage 7-9    1621 white prepupae new    2018 white prepupae 12hr    2132 white prepupae 24hr    2721 pupae 2d postWPP    1498 pupae 3d postWPP    739 pupae 4d postWPP    1305 adult male 01day    1000 adult male 05day    1385 adult male 30day    1599 adult female 01day    2786 adult female 05day    3360 adult female 30day    3773 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0043903 expression level Developmental Stage   Expression Level embryo 00-02hr    7909 embryo 02-04hr    13442 embryo 04-06hr    10496 embryo 06-08hr    9352 embryo 08-10hr    6243 embryo 10-12hr    4138 embryo 12-14hr    2955 embryo 14-16hr    4204 embryo 16-18hr    2767 embryo 18-20hr    2554 embryo 20-22hr    4802 embryo 22-24hr    3114 larva L1    1188 larva L2    763 larva L3 12hr old    738 larva L3 puffstage 1-2    813 larva L3 puffstage 3-6    1531 larva L3 puffstage 7-9    1621 white prepupae new    2018 white prepupae 12hr    2132 white prepupae 24hr    2721 pupae 2d postWPP    1498 pupae 3d postWPP    739 pupae 4d postWPP    1305 adult male 01day    1000 adult male 05day    1385 adult male 30day    1599 adult female 01day    2786 adult female 05day    3360 adult female 30day    3773 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7909) embryo 02-04hr  (13442) embryo 04-06hr  (10496) embryo 06-08hr  (9352) embryo 08-10hr  (6243) embryo 10-12hr  (4138) embryo 12-14hr  (2955) embryo 14-16hr  (4204) embryo 16-18hr  (2767) embryo 18-20hr  (2554) embryo 20-22hr  (4802) embryo 22-24hr  (3114) larva L1  (1188) larva L2  (763) larva L3 12hr old  (738) larva L3 puffstage 1-2  (813) larva L3 puffstage 3-6  (1531) larva L3 puffstage 7-9  (1621) white prepupae new  (2018) white prepupae 12hr  (2132) white prepupae 24hr  (2721) pupae 2d postWPP  (1498) pupae 3d postWPP  (739) pupae 4d postWPP  (1305) adult male 01day  (1000) adult male 05day  (1385) adult male 30day  (1599) adult female 01day  (2786) adult female 05day  (3360) adult female 30day  (3773) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7909) embryo 02-04hr  (13442) embryo 04-06hr  (10496) embryo 06-08hr  (9352) embryo 08-10hr  (6243) embryo 10-12hr  (4138) embryo 12-14hr  (2955) embryo 14-16hr  (4204) embryo 16-18hr  (2767) embryo 18-20hr  (2554) embryo 20-22hr  (4802) embryo 22-24hr  (3114) larva L1    1188 larva L2    763 larva L3 12hr old    738 larva L3 puffstage 1-2    813 larva L3 puffstage 3-6  1531 larva L3 puffstage 7-9  1621 white prepupae new  2018 white prepupae 12hr  2132 white prepupae 24hr  (2721) pupae 2d postWPP  1498 pupae 3d postWPP    739 pupae 4d postWPP    1305 adult male 01day    1000 adult male 05day    1385 adult male 30day  1599 adult female 01day  (2786) adult female 05day  (3360) adult female 30day  (3773) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7909 embryo 02-04hr  13442 embryo 04-06hr  10496 embryo 06-08hr    9352 embryo 08-10hr    6243 embryo 10-12hr    4138 embryo 12-14hr    2955 embryo 14-16hr    4204 embryo 16-18hr    2767 embryo 18-20hr    2554 embryo 20-22hr    4802 embryo 22-24hr    3114 larva L1    1188 larva L2    763 larva L3 12hr old    738 larva L3 puffstage 1-2    813 larva L3 puffstage 3-6    1531 larva L3 puffstage 7-9    1621 white prepupae new    2018 white prepupae 12hr    2132 white prepupae 24hr    2721 pupae 2d postWPP    1498 pupae 3d postWPP    739 pupae 4d postWPP    1305 adult male 01day    1000 adult male 05day    1385 adult male 30day    1599 adult female 01day    2786 adult female 05day    3360 adult female 30day    3773 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7909 embryo 02-04hr    13442 embryo 04-06hr    10496 embryo 06-08hr    9352 embryo 08-10hr    6243 embryo 10-12hr    4138 embryo 12-14hr    2955 embryo 14-16hr    4204 embryo 16-18hr    2767 embryo 18-20hr    2554 embryo 20-22hr    4802 embryo 22-24hr    3114 larva L1    1188 larva L2    763 larva L3 12hr old    738 larva L3 puffstage 1-2    813 larva L3 puffstage 3-6    1531 larva L3 puffstage 7-9    1621 white prepupae new    2018 white prepupae 12hr    2132 white prepupae 24hr    2721 pupae 2d postWPP    1498 pupae 3d postWPP    739 pupae 4d postWPP    1305 adult male 01day    1000 adult male 05day    1385 adult male 30day    1599 adult female 01day    2786 adult female 05day    3360 adult female 30day    3773 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0043903    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0043903 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0043903 expression level Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0043903 expression level Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    97.2   NA  Eye    138   NA  Brain    165.3   216.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    92   NA  Crop    187.7   190.4  Midgut    208.4   164.5  Hindgut    135.2   123.1  Malpighian Tubules    167.3   40.8  Fat Body    49.5   211.5  Salivary Gland    450.2   NA  Heart    132.725   215.9  Trachea    NA   NA  VirginFemale Spermatheca    114.5   NA  InseminatedFemale Spermatheca    156.6   NA  Ovary    361.2   NA  Testis    86.1   NA  Male Accessory Gland    187.6   160.025  Carcass    81 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043903 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14226-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | adult stage domeG0321 lethal | embryonic stage domeG0217 domeG0218 domeG0282 domeG0441 lethal | larval stage domeG0217 domeG0218 domeG0282 domeG0321 domeG0367 domeG0383 domeG0405 domeG0441 domeG0468 lethal | larval stage | recessive domeunspecified lethal | pharate adult stage domeG0264 domeG0321 lethal | prepupal stage domeG0321 lethal | pupal stage domeG0321 lethal | recessive domeG0009 domeG0199b domeG0217 domeG0218 domeG0264 domeG0282 domeG0321 domeG0367 domeG0405 domeG0441 domeG0468 domePG5 domePG14 domePG35 domePG125 domePL41 domePL58 domePL100 semi-lethal | recessive domeG0282 domeG0321 viable, with Scer\GAL4pnr-MD237 domeGD2612 domeGD14494 Sterility Allele female sterile, with Scer\GAL4slbo.2.6 domeScer\UAS.cCGHa domeScer\UAS.T:Avic\GFP-EGFP Other Phenotypes Allele memory defective | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch domedsRNA.Scer\UAS.cCa domeΔCYT.Scer\UAS visible, with Scer\GAL4dpp.blk1 domeScer\UAS.cCGHa visible, with Scer\GAL4ey.PH domeScer\UAS.cCGHa domeΔCYT.Scer\UAS visible, with Scer\GAL4ey.PU domeΔCYT.Scer\UAS visible, with Scer\GAL4pnr-MD237 domeGD2612 domeGD14494 visible | germline clone domeunspecified wild-type domehs.PC Phenotype manifest in Allele abdominal 4 ventral denticle belt | germline clone domeG0217 border follicle cell domePL100 domeunspecified border follicle cell, with Scer\GAL4slbo.2.6 domeΔCYT.Scer\UAS domeΔEXT.Scer\UAS domeScer\UAS.T:Avic\GFP-EGFP domeScer\UAS.cCGHa border follicle cell | somatic clone domeG0441 egg chamber domePL100 egg chamber & basement membrane | apical, with Scer\GAL4slbo.2.6 domeΔCYT.Scer\UAS embryonic/larval posterior spiracle domeG0264 domeG0321 domeG0367 domeG0405 domeG0441 domeG0468 embryonic/larval posterior spiracle | germline clone domeG0217 embryonic/larval proventriculus domeG0217 domeG0468 embryonic/larval spiracle domeG0009 domeG0199b domeG0217 domeG0218 domeG0264 domeG0282 domeG0367 domeG0405 domeG0441 domeG0468 embryonic abdominal segment 4, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 domeΔCYT.Scer\UAS domeΔTMCYT.Scer\UAS embryonic abdominal segment 4 | non-rescuable maternal effect | posterior domeG0441 embryonic abdominal segment 5, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 domeΔCYT.Scer\UAS domeΔTMCYT.Scer\UAS embryonic abdominal segment 5 | germline clone domeG0217 embryonic abdominal segment 5 | non-rescuable maternal effect domeG0441 embryonic abdominal segment 6 | germline clone domeG0217 embryonic abdominal segment 7 | germline clone domeG0217 embryonic abdominal segment 8 | germline clone domeG0217 embryonic abdominal segment, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 domeN.Scer\UAS embryonic head | rescuable maternal effect domeG0441 embryonic hindgut, with Scer\GAL4byn-Gal4 domeΔCYT.Scer\UAS embryonic segment, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 domeΔCYT.Scer\UAS domeΔTMCYT.Scer\UAS embryonic thoracic segment | germline clone domeG0217 embryonic thoracic segment | rescuable maternal effect domeG0441 eye, with Scer\GAL4dpp.blk1 domeScer\UAS.cCGHa eye, with Scer\GAL4ey.PH domeΔCYT.Scer\UAS domeScer\UAS.cCGHa eye, with Scer\GAL4ey.PU domeΔCYT.Scer\UAS eye disc anterior to the morphogenetic furrow, with Scer\GAL4Eq1 domeΔCYT.Scer\UAS filzkorper domeG0217 domeG0367 domeG0468 mesothoracic tergum, with Scer\GAL4pnr-MD237 domeGD2612 domeGD14494 midgut, with Scer\GAL4esg-NP5130, Scer\GAL80ts.αTub84B domeΔTMCYT.Scer\UAS domeScer\UAS.T:Avic\GFP-EGFP midgut, with Scer\GAL4how-24B, Scer\GAL80ts.αTub84B domeΔTMCYT.Scer\UAS mouth hooks | germline clone domeunspecified polar follicle cell, with Scer\GAL4slbo.2.6 domeΔCYT.Scer\UAS posterior spiracle primordium | germline clone domeunspecified presumptive embryonic/larval tracheal system domeG0441 presumptive embryonic/larval tracheal system | germline clone domeunspecified stigmatophore domeG0367 domeG0468 tracheal branch primordium | germline clone domeunspecified wing, with Scer\GAL4Bx-MS1096 domeΔEXT.Scer\UAS
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of dome Class Mutagen Stocks Known lesion domeG0009 loss of function allele 2 -- domeG0199b loss of function allele P-element activity 2 -- domeG0218 loss of function allele P-element activity 2 Yes domeG0264 loss of function allele P-element activity 2 Yes domeG0367 hypomorphic allele - genetic evidence P-element activity 2 Yes domeG0405 hypomorphic allele - genetic evidence P-element activity 2 Yes domeCB-5788-3 1 -- domed09436 P-element activity 1 -- domeG0282 loss of function allele P-element activity 1 -- domeG0321 hypomorphic allele - genetic evidence P-element activity 1 Yes domeG0441 loss of function allele P-element activity 1 Yes domeKG08434a P-element activity 1 -- dome5.1 wild-type allele P-element activity 0 Yes dome60441 0 -- dome9 0 -- domeG0217 loss of function allele P-element activity 0 Yes domeG0383 P-element activity 0 -- domeG0468 loss of function allele P-element activity 0 Yes domeGG01616 P-element activity 0 -- domePG125 Delta2-3 0 -- domePG14 Delta2-3 0 Yes domePG35 Delta2-3 0 Yes domePG5 Delta2-3 0 Yes domePL100 Delta2-3 0 Yes domePL41 Delta2-3 0 -- domePL58 Delta2-3 0 Yes domeunspecified 0 --
Alleles Carried on Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dome Class Mutagen Stocks Known lesion domeGD14494 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes domeGD2612 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeHMS00647 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeHMS01293 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeJF01269 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeJF01682 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeJF01758 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeKK104700 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domedsRNA.Scer\UAS.cCa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes domeGD116 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes domehs.PC in vitro construct - regulatory fusion 0 Yes domeMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes domeN.Scer\UAS in vitro construct - regulatory fusion 0 Yes domeScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes domeScer\UAS.cCGHa in vitro construct - regulatory fusion 0 Yes domeScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes domeScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes domeScer\UAS.T:Ecol\lacZ-Δα in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes domeScer\UAS.T:Ecol\lacZ-Δω in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes domeΔCYT.Scer\UAS in vitro construct - deletion 0 Yes domeΔEXT.Scer\UAS in vitro construct - regulatory fusion 0 Yes domeΔTMCYT.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6253 (Ryder, 2004.4.26)
Duplicated in	Dp(1;3)DC365 (Popodi et al., 2010-) Dp(1;3)DC550 (Popodi et al., 2010-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD116} NA P{GD2612} NA P{GD14494} NA P{KK104700} NA P{TRiP.HMS00647} NA P{TRiP.HMS01293} NA P{TRiP.JF01269} NA P{TRiP.JF01682} NA P{TRiP.JF01758} NA P{UAS-dome.C} NA P{UAS-dome.CGH} NA P{UAS-dome.EGFP} NA P{UAS-dome.G} NA P{UAS-dome.N} NA P{UAS-dome.RNAi} NA P{UAS-dome.ΔCYT} NA P{UAS-dome.ΔEXT} NA P{UAS-dome.ΔTMCYT} NA P{UAS-dome.Δα} NA P{UAS-dome.Δω} NA reporter construct P{dome-lacZ.SB} No P{dome-lacZ.SL} No P{dome-lacZ.SLF2.MUT3rd} No P{dome-lacZ.SLF2.MUT4th} No P{dome-lacZ.SLF2.MUT} No P{dome-lacZ.SLF2} No P{dome-lacZ.SLF4.2n3n} No P{dome-lacZ.SLF4.4n3n} No P{dome-lacZ.SLF4.MUT} No P{dome-lacZ.SLF4} No P{UAS-dome.Δα} No P{UAS-dome.Δω} No heat-shock construct P{hs-dome.C} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}domeCB-5788-3 NA P{SUPor-P}domeKG08434a NA P{UAS-dome.CGH}5.1 NA insertion of mobile activating element P{Mae-UAS.6.11}domeGG01616 NA P{XP}domed09436 NA insertion of enhancer trap P{lacW}domeG0199b No P{lacW}domeG0217 No P{lacW}domeG0218 No P{lacW}domeG0264 No P{lacW}domeG0282 No P{lacW}domeG0321 No P{lacW}domeG0367 No P{lacW}domeG0383 No P{lacW}domeG0405 No P{lacW}domeG0441 No P{lacW}domeG0468 No P{lacW}domePL41 No P{lacW}domePL58 No P{lacW}domePL100 No insertion of enhancer trap binary system P{GawB}domePG5 No P{GawB}domePG14 No P{GawB}domePG35 No P{GawB}domePG125 No
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
protein heterodimerization activity inferred from physical interaction with et (Makki et al., 2010) transmembrane signaling receptor activity inferred from genetic interaction with os AND inferred from sequence or structural similarity with human CNTFR AND inferred from sequence or structural similarity with human LIFR AND inferred from sequence or structural similarity with mouse Cntfr AND inferred from sequence or structural similarity with mouse Lifr (Brown et al., 2001)
Biological Process
CV term Evidence References
blastoderm segmentation inferred from mutant phenotype (Brown et al., 2001) border follicle cell migration inferred from mutant phenotype (Ghiglione et al., 2002, Medioni and Noselli, 2005) compound eye morphogenesis inferred from mutant phenotype (Tsai and Sun, 2004) hindgut morphogenesis inferred from mutant phenotype (Johansen et al., 2003) JAK-STAT cascade inferred from genetic interaction with hop AND inferred from genetic interaction with os (Chen et al., 2002) inferred from genetic interaction with Stat92E AND inferred from genetic interaction with os (Brown et al., 2001) long-term memory inferred from mutant phenotype (Copf et al., 2011) morphogenesis of an epithelium inferred from mutant phenotype (Feix et al., 2002) open tracheal system development inferred from mutant phenotype (Brown et al., 2001, Chen et al., 2002, Lovegrove et al., 2006) positive regulation of cell proliferation inferred from mutant phenotype (Buchon et al., 2010)
Cellular Component
CV term Evidence References
apicolateral plasma membrane inferred from direct assay (Ghiglione et al., 2002)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
cytokine binding non-traceable author statement (Devergne, 2002.9.4) protein tyrosine phosphatase activity non-traceable author statement (Morrison et al., 2000) transmembrane signaling receptor activity traceable author statement (Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004)
Biological Process
CV term Evidence References
blastoderm segmentation non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) epithelial cell fate determination, open tracheal system traceable author statement (Ghabrial et al., 2003) immune response traceable author statement (Agaisse and Perrimon, 2004) JAK-STAT cascade non-traceable author statement (Castelli-Gair et al., 2001, Chen et al., 2002, Brown, 2001.11.19, Devergne, 2002.9.4) traceable author statement (Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004) open tracheal system development non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) protein dephosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
apical plasma membrane traceable author statement (Castelli-Gair Hombria and Brown, 2002) plasma membrane inferred from sequence or structural similarity with human CNTFR AND inferred from sequence or structural similarity with human LIFR (Brown et al., 2001) non-traceable author statement (Feix et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dome allele Gene References domeG0217 os (Bach et al., 2003) domeG0264 os (Chen et al., 2002) domeG0367 os (Chen et al., 2002) Stat92E (Brown et al., 2001) domeG0441 hop (Chen et al., 2002) os (Chen et al., 2002) domeG0468 os (Bach et al., 2003) domeunspecified os (Brown et al., 2001) Stat92E (Ghiglione et al., 2002) Su(var)2-10 (Ghiglione et al., 2002) domeΔCYT.Scer\UAS hop (Brown et al., 2001) os (Ghiglione et al., 2002) unspecified os (Hombria et al., 2005) upd2 (Hombria et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59272 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0043903 DroID - A comprehensive database of gene and protein interactions. • FBgn0043903 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32976
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20270 Dere\GG18033 Dgri\GH12259 Dmoj\GI11020 Dper\GL18308 Dpse\GA12840 Dsec\GM22718 Dsim\GD24451 Dvir\GJ15619 Dwil\GK16477 Dyak\GE17362
Curated drosophilid orthologs	Dpse\GA12840
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012471-PA Aedes aegypti (mosquito) AGAP010083-PA Anopheles gambiae (mosquito) BGIBMGA005642-PA Bombyx mori (silk worm) CPIJ017416 Culex pipens (mosquito) 212023 Capitella spl (polychaete worm) ISCW001458-PA Ixodes scapularis (deer tick) PHUM009010-PA Pediculus humanus (human body louse) XP_001807060.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV22778 LH21919 ISCW013495 ISCW013496 ISCW008121 ISCW001458 FBgn0234832 FBgn0218479 FBgn0202809 FBgn0195787 FBgn0177588 JGI_V11_100606 FBgn0072885 FBgn0155910 FBgn0133783 FBgn0119738 FBgn0110251 FBgn0097277 CPIJ017416 BGIBMGA005642 ACYPI52669 ACYPI40958 ACYPI40957 ACYPI24864 ACYPI21996 ACYPI21995 ACYPI004970 GB12159 DOME PB19891 PHUM374950 GLEAN_01874
Stocks & Reagents
Stocks Listed in FlyBase ( 27 )
Bloomington	28983 y1 v1; P{TRiP.JF01682}attP2 31245 y1 v1; P{TRiP.JF01758}attP2 31474 y1 v1; P{TRiP.JF01269}attP2 10263 w67c23 P{lacW}domeG0282/FM7c 11953 w67c23 P{lacW}domeG0218/FM7c 11962 w67c23 P{lacW}domeG0264/FM7c 11971 w67c23 P{lacW}domeG0321/FM7c
Harvard	- P{XP}domed09436
VDRC	v106071 P{KK104700}VIE-260B v19717 w1118; P{GD2612}v19717 v36355 w1118; P{GD14494}v36355 v36356 w1118; P{GD14494}v36356
	More stocks available...
Genomic Clones ( 1 )
	BACR33M08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 73 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD46805
Other clones	DPiM_LD46805
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT15805 AT27072 GM02606 LD04367 LD18445 LD29548 LD32495 LD32858 LD36486 LD38319 LD43636 LD46211 RE02269 RE06686 RE09525 RE11515 RE16239 RE18245 RE29912 RE29936 RE48166 RE49181 RE50166 RE61316 RE67717 SD07146
Other clones	8016 10464 11115 21408 37674 50564 61784 72586 83739 104013 104751 108340 118239 119134 119433 145127 156178 166626 CK01.16D.B6 CK01.71C.H12 CK01.119B.E3 CK01682 Dmel_dig_003160_0655_1076 EC054739 EK045101 EK056863 EK063015 EK105829 EK110437 EK111759 EK134952 EK150138 EK185413 EK188225 EK201251 EK218657 EK229858 EK237317 EK238718 EK238848 EK271219 EK291404 GM13503 GM13581 LD24018
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0043903 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32976
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "master of marelle" based on its presumed role in the hop/Stat92E signal transduction pathway. (Chen et al., 2002)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dome mom (Chen, 2002.3.18) Source for identity of: dome vsp (Feix, 2002.3.19)
Source for database merge of	Source for merge of: CG14226 anon-18DEb (Bayraktaroglu, 2000.11.2) Source for merge of: dome CG14226 l(1)G0321 l(1)G0405 l(1)G0367 l(1)G0218 l(1)G0441 l(1)G0264 l(1)G0282 (Castelli-Gair Hombria, 2001.9.19)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Bartscherer et al., 2006) Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against dome results in a 12-24-fold decrease in JAK/STAT activity. (Baeg et al., 2005) dome protein is ubiquitously expressed in embryos, but its homodimerisation is developmentally regulated. dome protein homodimerisation is not ligand-induced. (Brown et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dome functions in the JAK/STAT signal transduction pathway, acting between os and hop. (Chen et al., 2002) dome functions as a receptor of the JAK/STAT signal transduction pathway. (Chen et al., 2002) dome mutants display a variety of epithelial defects including fusions of denticle belts, holes in the cuticle and a failure of proventricular primordial cells to migrate into the endodermal part of the organ. (Feix et al., 2002) dome is required for epithelial development. (Feix et al., 2002) dome is involved in border follicle cell determination and migration. (Ghiglione et al., 2002) dome codes for a transmembrane receptor required for all JAK/STAT functions in the embryo. (Brown et al., 2001) Zygotic mutants show disruption of the posterior spiracles. Embryos null for both maternal and zygotic dome function show segmental defects identical to those seen in null os, hop and Stat92E mutants. (Castelli-Gair et al., 2001) dome is a receptor of the pathway necessary for STAT activation. (Castelli-Gair et al., 2001) Not known to correspond to any of the known lethal complementation groups in 18D-18E region. (Fehon, 1997.3.25)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078688 RefSeq (Proteins) • NP_523412 DDBJ / EMBL / GenBank • AA951941 AAF49002 AAL68243 AAN64333 AI515110 AJ420377 AW943869 AY075427 AY147847 BH901033 BH901034 CAD12503 CZ476744 U85028 U85029 Entrez Gene - A searchable database of RefSeq genes. • 32976 UniProtKB/Swiss-Prot • Q9VWE0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Fibronectin, type III (IPR003961) Immunoglobulin-like fold (IPR013783)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59272 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0043903 DroID - A comprehensive database of gene and protein interactions. • FBgn0043903 DRSC - Results from RNAi screens. • FBgn0043903 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043903 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14226-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0043903 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 89266 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32976 InParanoid A subset of ortholog calls from InParanoid. • AAEL012471-PA Aedes aegypti (mosquito) AGAP010083-PA Anopheles gambiae (mosquito) BGIBMGA005642-PA Bombyx mori (silk worm) CPIJ017416 Culex pipens (mosquito) 212023 Capitella spl (polychaete worm) ISCW001458-PA Ixodes scapularis (deer tick) PHUM009010-PA Pediculus humanus (human body louse) XP_001807060.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/domeles1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32976 modMine - Data generated by the modENCODE project. • FBgn0043903 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV22778 LH21919 ISCW013495 ISCW013496 ISCW008121 ISCW001458 FBgn0234832 FBgn0218479 FBgn0202809 FBgn0195787 FBgn0177588 JGI_V11_100606 FBgn0072885 FBgn0155910 FBgn0133783 FBgn0119738 FBgn0110251 FBgn0097277 CPIJ017416 BGIBMGA005642 ACYPI52669 ACYPI40958 ACYPI40957 ACYPI24864 ACYPI21996 ACYPI21995 ACYPI004970 GB12159 DOME PB19891 PHUM374950 GLEAN_01874 REDfly - A database of transcriptional regulatory elements. • FBgn0043903
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	142932_at (Kristensen et al., 2005) anon-18DEb   CG14226 (Peter et al., 2002, Egger et al., 2002, Chen et al., 2002, Fehon, 1997.3.25, Maisonhaute et al., 2007, Ida et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Wertheim et al., 2005, Ni et al., 2008, Cheng et al., 2009, Ni et al., 2010.12.1) CT33841 (Hynes and Zhao, 2000) Dome (Waterhouse et al., 2007, Baeg et al., 2005, Agaisse et al., 2003, Hultmark and Ekengren, 2003, Bina and Zeidler, 2006, Yasugi et al., 2007, Keller, 2006, Nallamothu et al., 2008, Karsten et al., 2006, Gesellchen et al., 2005, Buchon et al., 2009, Wang and Huang, 2009, Shyu et al., 2009, Gilbert et al., 2009, Djiane and Mlodzik, 2010, Cheng et al., 2009, Kallio et al., 2010, Buchon et al., 2010, Jiang et al., 2011, Pastor-Pareja et al., 2008, Vidal et al., 2010) DOME (Rorth, 2002, Leclerc and Reichhart, 2004, Castelli-Gair Hombria, 2006, Arbouzova and Zeidler, 2006) dome (Arbouzova, 2006, Arbouzova et al., 2006, Bartscherer et al., 2006, Hombria et al., 2005, Tsai and Sun, 2004, Rivas et al., 2007, Mandal et al., 2007, Copf et al., 2011, Yu et al., 2008, Luque and Milan, 2007, Lovegrove et al., 2006, Yuva-Aydemir et al., 2011, Copf and Preat, 2008, Baeg et al., 2007, Maisonhaute et al., 2007, Brown et al., 2006, Ayala-Camargo et al., 2007, López-Onieva et al., 2008, Tsai et al., 2007, Furriols et al., 2007, Sotillos et al., 2008, Devergne et al., 2007, Ida et al., 2009, Charroux and Royet, 2009, Rivas et al., 2008, Flaherty et al., 2009, Cronin et al., 2009, Jiang et al., 2009, Ni et al., 2009, Owusu-Ansah and Banerjee, 2009, Gutierrez-Aviño et al., 2009, Wang et al., 2010, Beebe et al., 2010, Wertheim et al., 2005, Lin et al., 2010, Popodi et al., 2010-, Ngo et al., 2010, Ren et al., 2010, Wright et al., 2011, Gao et al., 2011) l(1)G0217 (Josten et al., 2004) l(1)G0218 (Schaefer et al., 1999.8.12, ) l(1)G0264 (Schaefer et al., 1999.8.12, ) l(1)G0282 (Schaefer et al., 1999.6.15, ) l(1)G0321 (Schaefer et al., 1999.8.12, ) l(1)G0367 (Schaefer et al., 1999.8.12, ) l(1)G0405 (Schaefer et al., 1999.8.12, ) l(1)G0441 (Schaefer et al., 1999.8.12, ) l(1)G0468 (Josten et al., 2004) mom (Chen et al., 2002, Chen et al., 2002, ) vsp (Josten et al., 2003, Feix et al., 2002, )
Name Synonym	domeless (Castelli-Gair et al., 2001, Bartscherer et al., 2006, Yu et al., 2008, Brown et al., 2006, Furriols et al., 2007, Devergne et al., 2007, Cronin et al., 2009, Jiang et al., 2009, Ni et al., 2009, Hill-Burns and Clark, 2009, Shyu et al., 2009, Beebe et al., 2010, Jacques et al., 2009, Mukherjee et al., 2005) Domeless (Gilbert et al., 2007, Yasugi et al., 2007, Arbouzova and Zeidler, 2006, Montell, 2006, Payne and Braun, 2006, Sotillos et al., 2008, Buchon et al., 2009, Buchon et al., 2009, Wang and Huang, 2009, Classen et al., 2009, Kallio et al., 2010, Buchon et al., 2010, Vidal et al., 2010, Makki et al., 2010) Dome receptor (Cheng et al., 2009) master of marelle (Chen et al., 2002, Chen et al., 2002) verstopft (Josten et al., 2003, Feix et al., 2002)
Secondary FlyBase IDs
	FBgn0019901 FBgn0027236 FBgn0028267 FBgn0028288 FBgn0028311 FBgn0028326 FBgn0028335 FBgn0028344 FBgn0031056
References ( 158 )
Generate a list of	All references relating to this gene ( 158 )
List References by type	Research paper  ( 83 ) Supplementary material  ( 10 ) Review  ( 20 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 18 ) FlyBase analysis  ( 2 ) Protein sequence record  ( 1 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 18 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Copf et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 8059--8064 Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. [FBrf0213703] Gao et al., 2011, genesis 49(3): 105--116 Odd-skipped maintains prohemocyte potency and blocks blood cell development in Drosophila. [FBrf0213344] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Wright et al., 2011, Cell. Signal. 23(5): 920--927 Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. [FBrf0213113] Xu et al., 2011, Dev. Biol. 354(1): 31--43 EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. [FBrf0213634] Yuva-Aydemir et al., 2011, J. Neurosci. 31(19): 7005--7015 Spinster Controls Dpp Signaling during Glial Migration in the Drosophila Eye. [FBrf0213705] Beebe et al., 2010, Dev. Biol. 338(1): 28--37 JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. [FBrf0209772] Buchon et al., 2010, BMC Biol. 8: 152 Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. [FBrf0212840] Djiane and Mlodzik, 2010, PLoS ONE 5(6): e11228 The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. [FBrf0211141] Kallio et al., 2010, FASEB J. 24(11): 4467--4479 Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. [FBrf0212202] Lin et al., 2010, J. Mol. Cell. Biol. 2(1): 37--49 Paracrine Unpaired Signaling through the JAK/STAT Pathway Controls Self-renewal and Lineage Differentiation of Drosophila Intestinal Stem Cells. [FBrf0209721] Makki et al., 2010, PLoS Biol. 8(8): e1000441 A short receptor downregulates Jak/STAT signalling to control the Drosophila cellular immune response. [FBrf0211466] Ngo et al., 2010, Dev. Biol. 346(2): 284--295 Concomitant requirement for Notch and Jak/Stat signaling during neuro-epithelial differentiation in the Drosophila optic lobe. [FBrf0211910] Ren et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(49): 21064--21069 Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. [FBrf0212502] Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466 Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. [FBrf0211993] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...