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Gene Dmel\dome

General Information
Symbol	Dmel\dome	Species	D. melanogaster
Name	domeless	Annotation symbol	CG14226
Feature type	protein_coding_gene	FlyBase ID	FBgn0043903
Gene Model Status	Current	Stock availability	27 publicly available
Also Known As	vsp, mom
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	18D13-18E1	Sequence location	X:19,570,094..19,577,551 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene domeless is referred to in FlyBase by the symbol Dmel\dome (CG14226, FBgn0043903). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transmembrane signaling receptor activity; protein heterodimerization activity. There is experimental evidence that it is involved in the biological process: blastoderm segmentation; morphogenesis of an epithelium; hindgut morphogenesis; border follicle cell migration; positive regulation of cell proliferation; locomotor rhythm; long-term memory; JAK-STAT cascade; open tracheal system development; compound eye morphogenesis. 49 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; multicellular structure; spiracle; integumentary specialisation; portion of tissue; adult segment; non-connected developing system; embryonic hindgut; epithelial cell; external compound sense organ. It has one annotated transcript and one annotated polypeptide. Protein features are: Fibronectin, type III; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632381_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dome. Gene sequence location is X:19570090..19577549.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 18D13-18E1   Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
Experimentally Determined Cytological Location
Cytogenetic map Notes References 18E-18F   (determined by in situ hybridisation) 18E (determined by in situ hybridisation) 18E1--2 (determined by in situ hybridisation)   (Peter et al., 2002) 18E-18E   (determined by in situ hybridisation) 18E1--2 (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 18E-18F   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15)
Experimentally Determined Recombination Data
Location	1- (Castelli-Gair et al., 2001)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dome for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dome-RA FBtr0074756  NM_078688   4875   1282
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dome-PA   FBpp0074525   142.4   1282   6.53     NP_523412   AAF49002
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Fibronectin, type III (IPR003961) Immunoglobulin-like fold (IPR013783)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141247   AA141248   AA201546   AA538827   AA695325   AA803561   AA803593   AA820417   AA949594   AA951780   AA951941   AE014298 AAF49002   AI455416   AI456459   AI512020   AI515110   AI518671   AI546125   AJ420377 CAD12503   AW943869   AY075427 AAL68243   AY147847 AAN64333   BF490569   BF500775   BG637595   BG637599   BG639826   BH901033   BH901034   BI162983   BI166532   BI168681   BI170148   BI173339   BI212962   BI234238   BI234261   BI363376   BI364129   BI364959   BI373885   BI484590   CO178490   CO189752   CO267443   CO272094   CO273307   CO273662   CO279520   CO286500   CO292939   CO303029   CO309633   CO312742   CO314637   CO315000   CO315048   CO318270   CO322479   CO328773   CZ476744   EC054739   EC077321   EC079843   EC083684   EC195834   EC197987   EC202945   EC203022   EC204313   EC208529   EC213274   EC214105   EC214308   EC215079   EC220842   EC222041   EC222673   EC223461   EC232317   EC235645   EC236937   EC248376   EV576121   U85028   U85029
UniProtKB/Swiss-Prot	Q9VWE0
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000436515 X:19,573,920..19,576,788 evidence=Reporter construct (in vivo) (Hombria et al., 2005, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Brown et al., 2001) Comment:transcript is maternally supplied embryonic stage 4 -- 17   organism | faint & ubiquitous   (Brown et al., 2001) embryonic stage 11   tracheal pit   (Brown et al., 2001) embryonic stage 14   organism | ubiquitous   (Hombria et al., 2005) pharynx   (Hombria et al., 2005) hindgut | anterior   (Hombria et al., 2005) posterior spiracle primordium   (Hombria et al., 2005, Brown et al., 2001) embryonic hindgut   (Brown et al., 2001) embryonic/larval pharynx   (Brown et al., 2001) presumptive embryonic/larval central nervous system   (Brown et al., 2001)
Additional Descriptive Data
	dome expression at embryonic stage 14 is ubiquitous, but more pronounced in the pharynx, the anterior hindgut, and the posterior spiracles. (Hombria et al., 2005)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apicolateral plasma membrane inferred from direct assay (Ghiglione et al., 2002)
Expression Deduced from Reporters
Reporter: P{lacW}domeG0367 Stage Tissue/Position (including subcellular localization) Reference oogenesis stage S5 -- S7   border follicle cell   • nucleus (Xi et al., 2003) centripetally migrating follicle cell   • nucleus (Xi et al., 2003) polar follicle cell   • nucleus (Xi et al., 2003) nurse follicle cell   • nucleus (Xi et al., 2003)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    216.175 Larval Midgut    190.4 Larval Hindgut    164.5 Larval Malpighian Tubules    123.1 Larval Fat Body    40.8 Larval Salivary Gland    211.5 Larval Trachea    215.9 Larval Carcass    160.025 Adult Head    97.2 Adult Eye    138 Adult Brain    165.3 Adult Thoracic-Abdominal Ganglion    92 Adult Crop    187.7 Adult Midgut    208.4 Adult Hindgut    135.2 Adult Malpighian Tubules    167.3 Adult Fat Body    49.5 Adult Salivary Gland    450.2 Adult Heart    132.725 Adult VirginFemale Spermatheca    114.5 Adult InseminatedFemale Spermatheca    156.6 Adult Ovary    361.2 Adult Testis    86.1 Adult Male Accessory Gland    187.6 Adult Carcass    81 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    97.2   NA  Eye    138   NA  Brain    165.3   216.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    92   NA  Crop    187.7   190.4  Midgut    208.4   164.5  Hindgut    135.2   123.1  Malpighian Tubules    167.3   40.8  Fat Body    49.5   211.5  Salivary Gland    450.2   NA  Heart    132.725   215.9  Trachea    NA   NA  VirginFemale Spermatheca    114.5   NA  InseminatedFemale Spermatheca    156.6   NA  Ovary    361.2   NA  Testis    86.1   NA  Male Accessory Gland    187.6   160.025  Carcass    81 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    30 central nervous system, pupae P8    15 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    26 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    7 carcass, larvae L3 wandering    32 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    59 ovary, mated 4-day female    66 testis, mated 4-day male    23 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (36) central nervous system, larvae L3  (30) central nervous system, pupae P8    15 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult  26 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    7 carcass, larvae L3 wandering  (32) carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (66) testis, mated 4-day male    23 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    30 central nervous system, pupae P8    15 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    26 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    7 carcass, larvae L3 wandering    32 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    59 ovary, mated 4-day female    66 testis, mated 4-day male    23 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    30 central nervous system, pupae P8    15 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    26 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    7 carcass, larvae L3 wandering    32 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    59 ovary, mated 4-day female    66 testis, mated 4-day male    23 accessory gland, mated 4-day male    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    30 central nervous system, pupae P8    15 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    26 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    7 carcass, larvae L3 wandering    32 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    59 ovary, mated 4-day female    66 testis, mated 4-day male    23 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (36) central nervous system, larvae L3  30 central nervous system, pupae P8    15 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult  26 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    7 carcass, larvae L3 wandering  32 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (66) testis, mated 4-day male    23 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    30 central nervous system, pupae P8    15 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    26 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    7 carcass, larvae L3 wandering    32 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    59 ovary, mated 4-day female    66 testis, mated 4-day male    23 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    30 central nervous system, pupae P8    15 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    26 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    7 carcass, larvae L3 wandering    32 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    59 ovary, mated 4-day female    66 testis, mated 4-day male    23 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    104 embryo 02-04hr    177 embryo 04-06hr    138 embryo 06-08hr    123 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    39 embryo 14-16hr    55 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    63 embryo 22-24hr    41 larva L1    16 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    21 white prepupae new    27 white prepupae 12hr    28 white prepupae 24hr    36 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    18 adult male 30day    21 adult female 01day    37 adult female 05day    44 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (104) embryo 02-04hr  (177) embryo 04-06hr  (138) embryo 06-08hr  (123) embryo 08-10hr  (82) embryo 10-12hr  (54) embryo 12-14hr  (39) embryo 14-16hr  (55) embryo 16-18hr  (36) embryo 18-20hr  (34) embryo 20-22hr  (63) embryo 22-24hr  (41) larva L1    16 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    21 white prepupae new  (27) white prepupae 12hr  (28) white prepupae 24hr  (36) pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    18 adult male 30day    21 adult female 01day  (37) adult female 05day  (44) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  104 embryo 02-04hr  (177) embryo 04-06hr  (138) embryo 06-08hr  (123) embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    39 embryo 14-16hr    55 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    63 embryo 22-24hr    41 larva L1    16 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    21 white prepupae new    27 white prepupae 12hr    28 white prepupae 24hr    36 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    18 adult male 30day    21 adult female 01day    37 adult female 05day    44 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    104 embryo 02-04hr    177 embryo 04-06hr    138 embryo 06-08hr    123 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    39 embryo 14-16hr    55 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    63 embryo 22-24hr    41 larva L1    16 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    21 white prepupae new    27 white prepupae 12hr    28 white prepupae 24hr    36 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    18 adult male 30day    21 adult female 01day    37 adult female 05day    44 adult female 30day    50 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    104 embryo 02-04hr    177 embryo 04-06hr    138 embryo 06-08hr    123 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    39 embryo 14-16hr    55 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    63 embryo 22-24hr    41 larva L1    16 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    21 white prepupae new    27 white prepupae 12hr    28 white prepupae 24hr    36 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    18 adult male 30day    21 adult female 01day    37 adult female 05day    44 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (104) embryo 02-04hr  (177) embryo 04-06hr  (138) embryo 06-08hr  (123) embryo 08-10hr  (82) embryo 10-12hr  (54) embryo 12-14hr  (39) embryo 14-16hr  (55) embryo 16-18hr  (36) embryo 18-20hr  (34) embryo 20-22hr  (63) embryo 22-24hr  (41) larva L1    16 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    21 white prepupae new  27 white prepupae 12hr  28 white prepupae 24hr  (36) pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    18 adult male 30day    21 adult female 01day  (37) adult female 05day  (44) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  104 embryo 02-04hr  (177) embryo 04-06hr  138 embryo 06-08hr  123 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    39 embryo 14-16hr    55 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    63 embryo 22-24hr    41 larva L1    16 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    21 white prepupae new    27 white prepupae 12hr    28 white prepupae 24hr    36 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    18 adult male 30day    21 adult female 01day    37 adult female 05day    44 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    104 embryo 02-04hr    177 embryo 04-06hr    138 embryo 06-08hr    123 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    39 embryo 14-16hr    55 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    63 embryo 22-24hr    41 larva L1    16 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    21 white prepupae new    27 white prepupae 12hr    28 white prepupae 24hr    36 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    18 adult male 30day    21 adult female 01day    37 adult female 05day    44 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    13 embryonic 1182-4H    31 embryonic GM2    19 embryonic Kc167    14 embryonic S1    32 embryonic S3    22 leg disc CME L1    14 wing disc CME-W2    7 wing disc ML-DmD8    24 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    24 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    28 ovary fGS/OSS    52 ovary OSC    48 ovary OSS    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (37) Schneider line 2 Sg4    13 embryonic 1182-4H  (31) embryonic GM2    19 embryonic Kc167    14 embryonic S1  (32) embryonic S3    22 leg disc CME L1    14 wing disc CME-W2    7 wing disc ML-DmD8    24 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3    15 wing disc ML-DmD21    24 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  (30) antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1  (30) CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2  (28) ovary fGS/OSS  (52) ovary OSC  (48) ovary OSS  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    13 embryonic 1182-4H    31 embryonic GM2    19 embryonic Kc167    14 embryonic S1    32 embryonic S3    22 leg disc CME L1    14 wing disc CME-W2    7 wing disc ML-DmD8    24 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    24 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    28 ovary fGS/OSS    52 ovary OSC    48 ovary OSS    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    13 embryonic 1182-4H    31 embryonic GM2    19 embryonic Kc167    14 embryonic S1    32 embryonic S3    22 leg disc CME L1    14 wing disc CME-W2    7 wing disc ML-DmD8    24 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    24 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    28 ovary fGS/OSS    52 ovary OSC    48 ovary OSS    50 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    13 embryonic 1182-4H    31 embryonic GM2    19 embryonic Kc167    14 embryonic S1    32 embryonic S3    22 leg disc CME L1    14 wing disc CME-W2    7 wing disc ML-DmD8    24 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    24 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    28 ovary fGS/OSS    52 ovary OSC    48 ovary OSS    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (37) Schneider line 2 Sg4    13 embryonic 1182-4H  31 embryonic GM2    19 embryonic Kc167    14 embryonic S1  32 embryonic S3    22 leg disc CME L1    14 wing disc CME-W2    7 wing disc ML-DmD8    24 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3    15 wing disc ML-DmD21    24 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  30 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1  30 CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2  28 ovary fGS/OSS  (52) ovary OSC  (48) ovary OSS  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    13 embryonic 1182-4H    31 embryonic GM2    19 embryonic Kc167    14 embryonic S1    32 embryonic S3    22 leg disc CME L1    14 wing disc CME-W2    7 wing disc ML-DmD8    24 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    24 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    28 ovary fGS/OSS    52 ovary OSC    48 ovary OSS    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    13 embryonic 1182-4H    31 embryonic GM2    19 embryonic Kc167    14 embryonic S1    32 embryonic S3    22 leg disc CME L1    14 wing disc CME-W2    7 wing disc ML-DmD8    24 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    24 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    28 ovary fGS/OSS    52 ovary OSC    48 ovary OSS    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (32) cold shock, 4-day adult    24 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult  (58) Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (54) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (40) Caffeine 25 mg/ml 48 hrs, 4-day adult  (27) Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (42) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  32 cold shock, 4-day adult    24 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult  (58) Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (54) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (40) Caffeine 25 mg/ml 48 hrs, 4-day adult  27 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (42) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043903 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14226-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | adult stage domeG0321 lethal | embryonic stage domeG0217 domeG0218 domeG0282 domeG0441 lethal | larval stage domeG0217 domeG0218 domeG0282 domeG0321 domeG0367 domeG0383 domeG0405 domeG0441 domeG0468 lethal | larval stage | recessive domeunspecified lethal | pharate adult stage domeG0264 domeG0321 lethal | prepupal stage domeG0321 lethal | pupal stage domeG0321 lethal | recessive domeG0009 domeG0199b domeG0217 domeG0218 domeG0264 domeG0282 domeG0321 domeG0367 domeG0405 domeG0441 domeG0468 domePG5 domePG14 domePG35 domePG125 domePL41 domePL58 domePL100 partially lethal - majority die | recessive domeG0282 domeG0321 viable, with Scer\GAL4pnr-MD237 domeGD2612 domeGD14494 Sterility Allele female sterile, with Scer\GAL4slbo.2.6 domeScer\UAS.cCGHa domeScer\UAS.T:Avic\GFP-EGFP Other Phenotypes Allele locomotor rhythm defective, with Scer\GAL4dome-PG14 domeΔCYT.Scer\UAS memory defective | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch domedsRNA.Scer\UAS.cCa domeΔCYT.Scer\UAS small body | adult stage, with Scer\GAL4VGAT.PF domeHMS00647 visible, with Scer\GAL4dpp.blk1 domeScer\UAS.cCGHa visible, with Scer\GAL4ey.PH domeScer\UAS.cCGHa domeΔCYT.Scer\UAS visible, with Scer\GAL4ey.PU domeΔCYT.Scer\UAS visible, with Scer\GAL4pnr-MD237 domeGD2612 domeGD14494 visible | adult stage, with Scer\GAL4en-e16E domeJF01269 visible | germline clone domeunspecified wild-type domehs.PC Phenotype manifest in Allele abdominal 4 ventral denticle belt | germline clone domeG0217 border follicle cell domePL100 domeunspecified border follicle cell, with Scer\GAL4slbo.2.6 domeΔCYT.Scer\UAS domeΔEXT.Scer\UAS domeScer\UAS.T:Avic\GFP-EGFP domeScer\UAS.cCGHa border follicle cell | somatic clone domeG0441 egg chamber domePL100 egg chamber & basement membrane | apical, with Scer\GAL4slbo.2.6 domeΔCYT.Scer\UAS embryonic/larval posterior spiracle domeG0264 domeG0321 domeG0367 domeG0405 domeG0441 domeG0468 embryonic/larval posterior spiracle | germline clone domeG0217 embryonic/larval proventriculus domeG0217 domeG0468 embryonic/larval spiracle domeG0009 domeG0199b domeG0217 domeG0218 domeG0264 domeG0282 domeG0367 domeG0405 domeG0441 domeG0468 embryonic abdominal segment 4, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 domeΔCYT.Scer\UAS domeΔTMCYT.Scer\UAS embryonic abdominal segment 4 | non-rescuable maternal effect | posterior domeG0441 embryonic abdominal segment 5, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 domeΔCYT.Scer\UAS domeΔTMCYT.Scer\UAS embryonic abdominal segment 5 | germline clone domeG0217 embryonic abdominal segment 5 | non-rescuable maternal effect domeG0441 embryonic abdominal segment 6 | germline clone domeG0217 embryonic abdominal segment 7 | germline clone domeG0217 embryonic abdominal segment 8 | germline clone domeG0217 embryonic abdominal segment, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 domeN.Scer\UAS embryonic head | rescuable maternal effect domeG0441 embryonic hindgut, with Scer\GAL4byn-Gal4 domeΔCYT.Scer\UAS embryonic segment, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 domeΔCYT.Scer\UAS domeΔTMCYT.Scer\UAS embryonic thoracic segment | germline clone domeG0217 embryonic thoracic segment | rescuable maternal effect domeG0441 eye, with Scer\GAL4dpp.blk1 domeScer\UAS.cCGHa eye, with Scer\GAL4ey.PH domeΔCYT.Scer\UAS domeScer\UAS.cCGHa eye, with Scer\GAL4ey.PU domeΔCYT.Scer\UAS eye disc | somatic clone, with Scer\GAL4Act.PU domeΔCYT.Scer\UAS eye disc anterior to the morphogenetic furrow, with Scer\GAL4Eq1 domeΔCYT.Scer\UAS filzkorper domeG0217 domeG0367 domeG0468 mesothoracic tergum, with Scer\GAL4pnr-MD237 domeGD2612 domeGD14494 midgut, with Scer\GAL4esg-NP5130, Scer\GAL80ts.αTub84B domeΔTMCYT.Scer\UAS domeScer\UAS.T:Avic\GFP-EGFP midgut, with Scer\GAL4how-24B, Scer\GAL80ts.αTub84B domeΔTMCYT.Scer\UAS mouth hooks | germline clone domeunspecified polar follicle cell, with Scer\GAL4slbo.2.6 domeΔCYT.Scer\UAS posterior spiracle primordium | germline clone domeunspecified presumptive embryonic/larval tracheal system domeG0441 presumptive embryonic/larval tracheal system | germline clone domeunspecified stigmatophore domeG0367 domeG0468 tracheal branch primordium | germline clone domeunspecified wing, with Scer\GAL4Bx-MS1096 domeΔEXT.Scer\UAS wing, with Scer\GAL4VGAT.PF domeHMS00647 wing vein | ectopic, with Scer\GAL4en-e16E domeJF01269
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of dome Class Mutagen Stocks Known lesion domeG0009 loss of function allele 2 -- domeG0199b loss of function allele P-element activity 2 -- domeG0218 loss of function allele P-element activity 2 Yes domeG0264 loss of function allele P-element activity 2 Yes domeG0367 hypomorphic allele - genetic evidence P-element activity 2 Yes domeG0405 hypomorphic allele - genetic evidence P-element activity 2 Yes domeCB-5788-3 1 -- domed09436 P-element activity 1 -- domeG0282 loss of function allele P-element activity 1 -- domeG0321 hypomorphic allele - genetic evidence P-element activity 1 Yes domeG0441 loss of function allele P-element activity 1 Yes domeKG08434a P-element activity 1 -- dome5.1 wild-type allele P-element activity 0 Yes dome60441 0 -- dome9 0 -- domeG0217 loss of function allele P-element activity 0 Yes domeG0383 P-element activity 0 -- domeG0468 loss of function allele P-element activity 0 Yes domeGG01616 P-element activity 0 -- domePG125 Delta2-3 0 -- domePG14 Delta2-3 0 Yes domePG35 Delta2-3 0 Yes domePG5 Delta2-3 0 Yes domePL100 Delta2-3 0 Yes domePL41 Delta2-3 0 -- domePL58 Delta2-3 0 Yes domeunspecified 0 --
Alleles Carried on Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dome Class Mutagen Stocks Known lesion domeGD14494 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes domeGD2612 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeHMS00647 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeHMS01293 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeJF01269 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeJF01682 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeJF01758 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domeKK104700 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes domedsRNA.Scer\UAS.cCa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes domeGD116 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes domehs.PC in vitro construct - regulatory fusion 0 Yes domeMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes domeN.Scer\UAS in vitro construct - regulatory fusion 0 Yes domeScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes domeScer\UAS.cCGHa in vitro construct - regulatory fusion 0 Yes domeScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes domeScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes domeScer\UAS.T:Ecol\lacZ-Δα in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes domeScer\UAS.T:Ecol\lacZ-Δω in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes domeΔCYT.Scer\UAS in vitro construct - deletion 0 Yes domeΔEXT.Scer\UAS in vitro construct - regulatory fusion 0 Yes domeΔTMCYT.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6253 (Ryder, 2004.4.26)
Duplicated in	Dp(1;3)DC365 (Popodi et al., 2010-) Dp(1;3)DC550 (Popodi et al., 2010-, Venken et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD116} NA P{GD2612} NA P{GD14494} NA P{KK104700} NA P{TRiP.HMS00647} NA P{TRiP.HMS01293} NA P{TRiP.JF01269} NA P{TRiP.JF01682} NA P{TRiP.JF01758} NA P{UAS-dome.C} NA P{UAS-dome.CGH} NA P{UAS-dome.EGFP} NA P{UAS-dome.G} NA P{UAS-dome.N} NA P{UAS-dome.RNAi} NA P{UAS-dome.ΔCYT} NA P{UAS-dome.ΔEXT} NA P{UAS-dome.ΔTMCYT} NA P{UAS-dome.Δα} NA P{UAS-dome.Δω} NA reporter construct P{dome-lacZ.SB} No P{dome-lacZ.SL} No P{dome-lacZ.SLF2.MUT3rd} No P{dome-lacZ.SLF2.MUT4th} No P{dome-lacZ.SLF2.MUT} No P{dome-lacZ.SLF2} No P{dome-lacZ.SLF4.2n3n} No P{dome-lacZ.SLF4.4n3n} No P{dome-lacZ.SLF4.MUT} No P{dome-lacZ.SLF4} No P{UAS-dome.Δα} No P{UAS-dome.Δω} No heat-shock construct P{hs-dome.C} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}domeCB-5788-3 NA P{SUPor-P}domeKG08434a NA P{UAS-dome.CGH}5.1 NA insertion of mobile activating element P{Mae-UAS.6.11}domeGG01616 NA P{XP}domed09436 NA insertion of enhancer trap P{lacW}domeG0199b No P{lacW}domeG0217 No P{lacW}domeG0218 No P{lacW}domeG0264 No P{lacW}domeG0282 No P{lacW}domeG0321 No P{lacW}domeG0367 No P{lacW}domeG0383 No P{lacW}domeG0405 No P{lacW}domeG0441 No P{lacW}domeG0468 No P{lacW}domePL41 No P{lacW}domePL58 No P{lacW}domePL100 No insertion of enhancer trap binary system P{GawB}domePG5 No P{GawB}domePG14 No P{GawB}domePG35 No P{GawB}domePG125 No
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
protein heterodimerization activity inferred from physical interaction with et (Makki et al., 2010) transmembrane signaling receptor activity inferred from genetic interaction with os AND inferred from sequence or structural similarity with human CNTFR AND inferred from sequence or structural similarity with human LIFR AND inferred from sequence or structural similarity with mouse Cntfr AND inferred from sequence or structural similarity with mouse Lifr (Brown et al., 2001)
Biological Process
CV term Evidence References
blastoderm segmentation inferred from mutant phenotype (Brown et al., 2001) border follicle cell migration inferred from mutant phenotype (Ghiglione et al., 2002, Medioni and Noselli, 2005) compound eye morphogenesis inferred from mutant phenotype (Tsai and Sun, 2004) hindgut morphogenesis inferred from mutant phenotype (Johansen et al., 2003) JAK-STAT cascade inferred from genetic interaction with hop AND inferred from genetic interaction with os (Chen et al., 2002) inferred from genetic interaction with Stat92E AND inferred from genetic interaction with os (Brown et al., 2001) locomotor rhythm inferred from mutant phenotype (Luo and Sehgal, 2012) long-term memory inferred from mutant phenotype (Copf et al., 2011) morphogenesis of an epithelium inferred from mutant phenotype (Feix et al., 2002) open tracheal system development inferred from mutant phenotype (Brown et al., 2001, Chen et al., 2002, Lovegrove et al., 2006) positive regulation of cell proliferation inferred from mutant phenotype (Buchon et al., 2010)
Cellular Component
CV term Evidence References
apicolateral plasma membrane inferred from direct assay (Ghiglione et al., 2002)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
cytokine binding non-traceable author statement (Devergne, 2002.9.4) protein tyrosine phosphatase activity non-traceable author statement (Morrison et al., 2000) transmembrane signaling receptor activity traceable author statement (Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004)
Biological Process
CV term Evidence References
blastoderm segmentation non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) epithelial cell fate determination, open tracheal system traceable author statement (Ghabrial et al., 2003) immune response traceable author statement (Agaisse and Perrimon, 2004) JAK-STAT cascade non-traceable author statement (Castelli-Gair et al., 2001, Chen et al., 2002, Brown, 2001.11.19, Devergne, 2002.9.4) traceable author statement (Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004) open tracheal system development non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) protein dephosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
apical plasma membrane traceable author statement (Castelli-Gair Hombria and Brown, 2002) plasma membrane inferred from sequence or structural similarity with human CNTFR AND inferred from sequence or structural similarity with human LIFR (Brown et al., 2001) non-traceable author statement (Feix et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dome - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - 14-3-3ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - AP-1μ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Arf102F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - BCAS2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG10916 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG12128 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG14767 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG17454 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG2064 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG3164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG32138 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG32344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG3335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG34163 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG7668 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG9253 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - CG9769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Cypl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Eb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Int6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Mtr3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Nmnat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - PH4αEFB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Pi3K21B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Pvr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Rap2l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - RpS29 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Rpt4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Rs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - SmD2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Srp54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Su(dx) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Tom20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - bor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - et anti tag coimmunoprecipitation, anti tag western blot (Kallio et al., 2010) dome - fax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - holn1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - hop anti tag coimmunoprecipitation, anti tag western blot (Kallio et al., 2010) dome - l(1)G0320 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - mRpL24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - mRpL42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - mRpL52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - mRpL9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - mge anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - nes anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - pont anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - tws anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dome - wal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dome allele Gene References domeG0217 os (Bach et al., 2003) domeG0264 os (Chen et al., 2002) domeG0367 os (Chen et al., 2002) Stat92E (Brown et al., 2001) domeG0441 hop (Chen et al., 2002) os (Chen et al., 2002) domeG0468 os (Bach et al., 2003) domeunspecified os (Brown et al., 2001) Stat92E (Ghiglione et al., 2002) Su(var)2-10 (Ghiglione et al., 2002) domeΔCYT.Scer\UAS hop (Brown et al., 2001) os (Ghiglione et al., 2002) unspecified os (Hombria et al., 2005) upd2 (Hombria et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59272 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0043903 DroID - A comprehensive database of gene and protein interactions. • FBgn0043903 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32976 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VWE0
Orthologs
OrthoDB Orthologs (48) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6C5D3W Dipteran inclusive ortholog search EOG6M920K Insect inclusive ortholog search EOG6WPZXJ Arthropod inclusive ortholog search EOG666T1W Metazoa inclusive ortholog search EOG612ZZC
Orthologs in Drosophila Species (EOG6C5D3W)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dome     Drosophila simulans   Dsim\GD24451 Y   Drosophila sechellia   Dsec\GM22718 Y   Drosophila erecta   Dere\GG18033 Y   Drosophila yakuba   Dyak\GE17362 Y   Drosophila ananassae   Dana\GF20270 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12840 Y   Drosophila persimilis   Dper\GL18308 Y   Drosophila willistoni   Dwil\GK16477 Y   Drosophila virilis   Dvir\GJ15619 Y   Drosophila mojavensis   Dmoj\GI11020 Y   Drosophila grimshawi   Dgri\GH12259 Y
Orthologs in non-Drosophila Dipterans (EOG6M920K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012471   Anopheles gambiae Malaria mosquito  Agam\DOME   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017416
Orthologs in non-Dipteran Insects (EOG6WPZXJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC100576169   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008383   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14547   Atta cephalotes Leafcutter ant  Acep\ACEP10646   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15112   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15113   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13547   Linepithema humile Argentine ant  Lhum\LH21919   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19891   Solenopsis invicta Red fire ant  Sinv\SINV26181   Acyrthosiphon pisum Pea aphid  Apim\ACYPI24864   Acyrthosiphon pisum Pea aphid  Apim\ACYPI40958   Acyrthosiphon pisum Pea aphid  Apim\ACYPI082699   Acyrthosiphon pisum Pea aphid  Apim\ACYPI084284   Acyrthosiphon pisum Pea aphid  Apim\ACYPI080663   Acyrthosiphon pisum Pea aphid  Apim\ACYPI21996   Acyrthosiphon pisum Pea aphid  Apim\ACYPI56790   Acyrthosiphon pisum Pea aphid  Apim\ACYPI40957   Acyrthosiphon pisum Pea aphid  Apim\ACYPI21995   Acyrthosiphon pisum Pea aphid  Apim\ACYPI086312   Bombyx mori Silkmoth  Bmor\BGIBMGA005642   Pediculus humanus Human body louse  Phum\PHUM374950   Tribolium castaneum Red flour beetle  Tcas\Dome
Orthologs in non-Insect Arthropods (EOG666T1W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_100606 Y Daphnia pulex Water flea  Dpux\Tp63 Y Ixodes scapularis Deer tick  Isca\ISCW001458 Y Ixodes scapularis Deer tick  Isca\ISCW013496 Y Ixodes scapularis Deer tick  Isca\ISCW013495 Y Ixodes scapularis Deer tick  Isca\ISCW008121 Y Ixodes scapularis Deer tick  Isca\ISCW010023 Y
Orthologs in non-Arthropod Metazoa (EOG612ZZC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009039gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028100gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026349gn Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24451 Drosophila sechellia Dsec\GM22718 Drosophila erecta Dere\GG18033 Drosophila yakuba Dyak\GE17362 Drosophila ananassae Dana\GF20270 Drosophila pseudoobscura pseudoobscura Dpse\GA12840 Drosophila persimilis Dper\GL18308 Drosophila willistoni Dwil\GK16477 Drosophila virilis Dvir\GJ15619 Drosophila mojavensis Dmoj\GI11020 Drosophila grimshawi Dgri\GH12259
Stocks & Reagents
Stocks Listed in FlyBase ( 27 )
Bloomington	28983 y1 v1; P{TRiP.JF01682}attP2 31245 y1 v1; P{TRiP.JF01758}attP2 31474 y1 v1; P{TRiP.JF01269}attP2 10263 w67c23 P{lacW}domeG0282/FM7c 11953 w67c23 P{lacW}domeG0218/FM7c 11962 w67c23 P{lacW}domeG0264/FM7c 11971 w67c23 P{lacW}domeG0321/FM7c
Harvard	- P{XP}domed09436
VDRC	v106071 P{KK104700}VIE-260B v19717 w1118; P{GD2612}v19717 v36355 w1118; P{GD14494}v36355 v36356 w1118; P{GD14494}v36356
	More stocks available...
Genomic Clones ( 1 )
	BACR33M08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 73 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD46805
Other clones	DPiM_LD46805
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT15805 AT27072 GM02606 LD04367 LD18445 LD29548 LD32495 LD32858 LD36486 LD38319 LD43636 LD46211 RE02269 RE06686 RE09525 RE11515 RE16239 RE18245 RE29912 RE29936 RE48166 RE49181 RE50166 RE61316 RE67717 SD07146
Other clones	8016 10464 11115 21408 37674 50564 61784 72586 83739 104013 104751 108340 118239 119134 119433 145127 156178 166626 CK01.16D.B6 CK01.71C.H12 CK01.119B.E3 CK01682 Dmel_dig_003160_0655_1076 EC054739 EK045101 EK056863 EK063015 EK105829 EK110437 EK111759 EK134952 EK150138 EK185413 EK188225 EK201251 EK218657 EK229858 EK237317 EK238718 EK238848 EK271219 EK291404 GM13503 GM13581 LD24018
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0043903 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32976
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "master of marelle" based on its presumed role in the hop/Stat92E signal transduction pathway. (Chen et al., 2002)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dome mom (Chen, 2002.3.18) Source for identity of: dome vsp (Feix, 2002.3.19)
Source for database merge of	Source for merge of: CG14226 anon-18DEb (Bayraktaroglu, 2000.11.2) Source for merge of: dome CG14226 l(1)G0321 l(1)G0405 l(1)G0367 l(1)G0218 l(1)G0441 l(1)G0264 l(1)G0282 (Castelli-Gair Hombria, 2001.9.19)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Bartscherer et al., 2006) Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against dome results in a 12-24-fold decrease in JAK/STAT activity. (Baeg et al., 2005) dome protein is ubiquitously expressed in embryos, but its homodimerisation is developmentally regulated. dome protein homodimerisation is not ligand-induced. (Brown et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dome functions in the JAK/STAT signal transduction pathway, acting between os and hop. (Chen et al., 2002) dome functions as a receptor of the JAK/STAT signal transduction pathway. (Chen et al., 2002) dome mutants display a variety of epithelial defects including fusions of denticle belts, holes in the cuticle and a failure of proventricular primordial cells to migrate into the endodermal part of the organ. (Feix et al., 2002) dome is required for epithelial development. (Feix et al., 2002) dome is involved in border follicle cell determination and migration. (Ghiglione et al., 2002) dome codes for a transmembrane receptor required for all JAK/STAT functions in the embryo. (Brown et al., 2001) Zygotic mutants show disruption of the posterior spiracles. Embryos null for both maternal and zygotic dome function show segmental defects identical to those seen in null os, hop and Stat92E mutants. (Castelli-Gair et al., 2001) dome is a receptor of the pathway necessary for STAT activation. (Castelli-Gair et al., 2001) Not known to correspond to any of the known lethal complementation groups in 18D-18E region. (Fehon, 1997.3.25)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078688 RefSeq (Proteins) • NP_523412 DDBJ / EMBL / GenBank • AA951941 AAF49002 AAL68243 AAN64333 AI515110 AJ420377 AW943869 AY075427 AY147847 BH901033 BH901034 CAD12503 CZ476744 U85028 U85029 Entrez Gene - A searchable database of RefSeq genes. • 32976 UniProtKB/Swiss-Prot • Q9VWE0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Fibronectin, type III (IPR003961) Immunoglobulin-like fold (IPR013783)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59272 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0043903 DroID - A comprehensive database of gene and protein interactions. • FBgn0043903 DRSC - Results from RNAi screens. • FBgn0043903 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0043903 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14226-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0043903 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 89266 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32976 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/domeles1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32976 modMine - Data generated by the modENCODE project. • FBgn0043903 REDfly - A database of transcriptional regulatory elements. • FBgn0043903 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VWE0
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	142932_at (Kristensen et al., 2005) anon-18DEb   CG14226 (Peter et al., 2002, Egger et al., 2002, Chen et al., 2002, Fehon, 1997.3.25, Maisonhaute et al., 2007, Schiess et al., 2009, Ida et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Wertheim et al., 2005, Ni et al., 2008, Cheng et al., 2009, Ni et al., 2010.12.1) CT33841 (Hynes and Zhao, 2000) Dome (Waterhouse et al., 2007, Baeg et al., 2005, Agaisse et al., 2003, Hultmark and Ekengren, 2003, Bina and Zeidler, 2006, Yasugi et al., 2007, Keller, 2006, Kulkarni et al., 2011, Nallamothu et al., 2008, Bond and Foley, 2009, Wu et al., 2010, Karsten et al., 2006, Gesellchen et al., 2005, Buchon et al., 2009, Wang and Huang, 2009, Shyu et al., 2009, Gilbert et al., 2009, Djiane and Mlodzik, 2010, Cheng et al., 2009, Kallio et al., 2010, Buchon et al., 2010, Jiang et al., 2011, Pastor-Pareja et al., 2008, Vidal et al., 2010, Sun et al., 2011) DOME (Rorth, 2002, Leclerc and Reichhart, 2004, Castelli-Gair Hombria, 2006, Arbouzova and Zeidler, 2006, Luo and Sehgal, 2012) dome (Arbouzova, 2006, Arbouzova et al., 2006, Bartscherer et al., 2006, Hombria et al., 2005, Tsai and Sun, 2004, Rivas et al., 2007, Mandal et al., 2007, Copf et al., 2011, Rajan and Perrimon, 2012, Yu et al., 2008, Luque and Milan, 2007, Lovegrove et al., 2006, Yuva-Aydemir et al., 2011, Copf and Preat, 2008, Baeg et al., 2007, Maisonhaute et al., 2007, Brown et al., 2006, Ayala-Camargo et al., 2007, González et al., 2009, Wang et al., 2011, Tokusumi et al., 2011, Li et al., 2011, Ni et al., 2008, López-Onieva et al., 2008, Tsai et al., 2007, Furriols et al., 2007, Sotillos et al., 2008, Devergne et al., 2007, Ida et al., 2009, Charroux and Royet, 2009, Rivas et al., 2008, Flaherty et al., 2009, Cronin et al., 2009, Jiang et al., 2009, Hayashi et al., 2012, Ni et al., 2009, Owusu-Ansah and Banerjee, 2009, Gutierrez-Aviño et al., 2009, Wang et al., 2010, Beebe et al., 2010, Wertheim et al., 2005, Lin et al., 2010, Popodi et al., 2010-, Ngo et al., 2010, Ren et al., 2010, Classen et al., 2009, Wright et al., 2011, Gao et al., 2011, Tokusumi et al., 2012, Feng et al., 2012, Venken et al., 2010, Luo and Sehgal, 2012, Graves et al., 2012) l(1)G0217 (Josten et al., 2004) l(1)G0218 (Schaefer et al., 1999.8.12, ) l(1)G0264 (Schaefer et al., 1999.8.12, ) l(1)G0282 (Schaefer et al., 1999.6.15, ) l(1)G0321 (Schaefer et al., 1999.8.12, ) l(1)G0367 (Schaefer et al., 1999.8.12, ) l(1)G0405 (Schaefer et al., 1999.8.12, ) l(1)G0441 (Schaefer et al., 1999.8.12, ) l(1)G0468 (Josten et al., 2004) mom (Chen et al., 2002, Chen et al., 2002, ) vsp (Josten et al., 2003, Feix et al., 2002, )
Name Synonym	domeless (Castelli-Gair et al., 2001, Bartscherer et al., 2006, Yu et al., 2008, Kulkarni et al., 2011, Hazelett et al., 2012, Brown et al., 2006, Wagner et al., 2009, Furriols et al., 2007, Devergne et al., 2007, Cronin et al., 2009, Jiang et al., 2009, Ni et al., 2009, Hill-Burns and Clark, 2009, Shyu et al., 2009, Beebe et al., 2010, Jacques et al., 2009, Mukherjee et al., 2005, Ni et al., 2008) Domeless (Gilbert et al., 2007, Yasugi et al., 2007, Arbouzova and Zeidler, 2006, Montell, 2006, Payne and Braun, 2006, Karpac et al., 2011, Sotillos et al., 2008, Buchon et al., 2009, Buchon et al., 2009, Wang and Huang, 2009, Classen et al., 2009, Kallio et al., 2010, Buchon et al., 2010, Vidal et al., 2010, Makki et al., 2010, Sun et al., 2011) DOMELESS (Luo and Sehgal, 2012) Dome receptor (Cheng et al., 2009) master of marelle (Chen et al., 2002, Chen et al., 2002) verstopft (Josten et al., 2003, Feix et al., 2002)
Secondary FlyBase IDs
	FBgn0019901 FBgn0027236 FBgn0028267 FBgn0028288 FBgn0028311 FBgn0028326 FBgn0028335 FBgn0028344 FBgn0031056
References ( 188 )
Generate a list of	All references relating to this gene ( 188 )
List References by type	Research paper  ( 110 ) Supplementary material  ( 11 ) Review  ( 20 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 19 ) Abstract  ( 18 ) FlyBase analysis  ( 2 ) Protein sequence record  ( 1 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 30 )
	Borensztejn et al., 2013, Development 140(1): 195--204 JAK/STAT autocontrol of ligand-producing cell number through apoptosis. [FBrf0220206] Staller et al., 2013, Genetics 193(1): 51--61 Depleting Gene Activities in Early Drosophila Embryos with the "Maternal-Gal4-shRNA" System. [FBrf0220341] Feng et al., 2012, Genetics 190(1): 279--282 Diverse Tumor Pathology due to Distinctive Patterns of JAK/STAT Pathway Activation Caused by Different Drosophila polyhomeotic Alleles. [FBrf0217136] Fisher et al., 2012, BMC Genomics 13: 506 Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. [FBrf0220361] Graves et al., 2012, PLoS ONE 7(6): e37615 Notch signaling activates yorkie non-cell autonomously in Drosophila. [FBrf0218547] Hayashi et al., 2012, Development 139(22): 4162--4171 Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen. [FBrf0219707] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Herranz et al., 2012, Genes Dev. 26(14): 1602--1611 Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. [FBrf0218898] Herranz et al., 2012, Curr. Biol. 22(8): 651--657 Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. [FBrf0220229] Luo and Sehgal, 2012, Cell 148(4): 765--779 Regulation of Circadian Behavioral Output via a MicroRNA-JAK/STAT Circuit. [FBrf0217497] Rajan and Perrimon, 2012, Cell 151(1): 123--137 Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. 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