mom, vsp, l(1)G0264, l(1)G0218, l(1)G0367
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with wdp; the interaction promotes internalization of dome and its subsequent lysosomal degradation; thereby reducing JAK/STAT signaling.
Undergoes lysosomal degradation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dome using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\dome in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene.
Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against dome results in a 12-24-fold decrease in JAK/STAT activity.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dome mutants display a variety of epithelial defects including fusions of denticle belts, holes in the cuticle and a failure of proventricular primordial cells to migrate into the endodermal part of the organ.
dome codes for a transmembrane receptor required for all JAK/STAT functions in the embryo.
Zygotic mutants show disruption of the posterior spiracles. Embryos null for both maternal and zygotic dome function show segmental defects identical to those seen in null os, hop and Stat92E mutants.
Not known to correspond to any of the known lethal complementation groups in 18D-18E region.