wf, wingful, l(3)72CDf, l(3)72Da
alpha/ß-hydrolase - Wingless antagonist - acts to induce cleavage of the Dlp glypican at the level of its GPI anchor leading to shedding of Dlp -spatially regulated modification of Dlp by Notum employs the ligand binding activity of Dlp to promote or inhibit signaling in a context-dependent manner
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Notum using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Notum in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
"l(3)72Db" does not correspond to "Notum"; "l(3)72Db8" complements a "Notum" mutant.
Source for merge of Notum CG13076 was sequence comparison ( date:020425 ).
Source for merge of Notum anon-WO0118547.482 anon-WO03062410.10 anon-WO03062410.8 was sequence comparison ( date:051113 ).
The 'l(3)72Da' (Notum) complementation group comprises 8 EMS-induced mutant alleles.
Homozygous mutants for Notum develop an excess of naked cuticle during embryogenesis. Mutant larvae have wing pouch duplications, resulting in a loss of notum specification.
Identified during a mutagenesis of the 71F-72D region.