FlyBase Gene Report: Dmel\Ilp5

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Gene: Dmel\Ilp5

General Information

Symbol

Dmel\Ilp5

Species

D. melanogaster

Name

Insulin-like peptide 5

Annotation Symbol

CG33273

Feature Type

protein_coding_gene

FlyBase ID

FBgn0044048

Gene Model Status

Stock Availability

19 publicly available

Gene Summary

Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

dilp5, DILP-5, Ilp-5, Dilp 5, DILP

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:9,823,349..9,823,897 [-]

Recombination map

3-31

RefSeq locus

NT_037436 REGION:9823349..9823897

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables insulin receptor binding

inferred from physical interaction with FLYBASE:InR; FB:FBgn0283499

(Sajid et al., 2011)

enables protein binding

inferred from physical interaction with FLYBASE:ImpL2; FB:FBgn0001257

(Sajid et al., 2011)

enables receptor ligand activity

inferred from direct assay

(Post et al., 2018, Sajid et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables hormone activity

inferred from electronic annotation with InterPro:IPR016179, InterPro:IPR022352

(InterPro Project Members, 2004-)

enables insulin receptor binding

inferred from sequence or structural similarity with UniProtKB:Q9VT51

(Brogiolo et al., 2001)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in carbohydrate homeostasis

inferred from direct assay

(Sajid et al., 2011)

involved_in female mating behavior

inferred from mutant phenotype

(Wigby et al., 2011)

involved_in insulin receptor signaling pathway

inferred from direct assay

(Post et al., 2018, Sajid et al., 2011)

involved_in locomotory behavior

inferred from mutant phenotype

(Metaxakis et al., 2014)

involved_in negative regulation of entry into reproductive diapause

inferred from mutant phenotype

(Schiesari et al., 2016)

involved_in sleep

inferred from mutant phenotype

(Metaxakis et al., 2014)

NOT involved_in circadian rhythm

inferred from mutant phenotype

(Metaxakis et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in insulin receptor signaling pathway

inferred from sequence or structural similarity with UniProtKB:Q9VT51

(Brogiolo et al., 2001)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Sajid et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from electronic annotation with InterPro:IPR016179

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

INSULIN-LIKE PEPTIDES

Pathway (FlyBase)

Insulin-like Receptor Signaling Pathway Core Components

Protein Family (UniProt)

Belongs to the insulin family. (Q7KUD5)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females. [Date last reviewed: 2019-07-11]

Gene Group (FlyBase)

NEUROPEPTIDES -: Neuropeptides are secreted into the extracellular space where they interact with cell surface receptors (usually G protein coupled receptors). They are extremely diverse, acting as neurotransmitters, neuromodulators, hormones or growth factors. (Adapted from FBrf0211443 and PMID:27813667).
INSULIN-LIKE PEPTIDES -: The insulin superfamily consists of peptides such as vertebrate insulins, mammalian relaxin and insulin-like growth factors, and invertebrate insulin-like peptides (ILP). They are synthesized as pre-propeptides and processed to yield two peptides, A and B, linked by disulfide bonds. ILPs have been identified throughout invertebrate species. In D.mel, ILPs may function as peptide hormones and/or neuropeptides. They have been linked to the regulation of growth and development. (Adapted from FBrf0189697 and FBrf0152330).

Pathway (FlyBase)

Insulin-like Receptor Signaling Pathway Core Components -: The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Ilp5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KUD5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 6.16

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0472645

478

108

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0422627

12.0

108

7.80

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

(UniProt, Q7KUD5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q7KUD5

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ilp5 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ilp5_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.68

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

second instar larval stage -- third instar larval stage

insulin secreting cell of pars intercerebralis of larval pars intercerebralis

(Ikeya et al., 2002)

third instar larval stage

larval brain | anterior | medial | restricted

(Brogiolo et al., 2001)

embryonic/larval midgut

(Brogiolo et al., 2001)

insulin secreting cell of pars intercerebralis

(Broughton et al., 2005)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

larval insulin secreting cell of pars intercerebralis

(Okamoto and Nishimura, 2015)

second instar larval stage

larval insulin secreting cell of pars intercerebralis

(Okamoto and Nishimura, 2015)

third instar larval stage

larval insulin secreting cell of pars intercerebralis

(Okamoto and Nishimura, 2015)

(Slaidina et al., 2009)

embryonic/larval Malpighian tubule Type I cell

(Söderberg et al., 2011)

(Söderberg et al., 2011)

prepupal stage P1 -- P4

(Slaidina et al., 2009)

prepupal stage P1 -- pharate adult stage P15

(Slaidina et al., 2009)

adult stage | male

(Slaidina et al., 2009)

adult stage | female

(Slaidina et al., 2009)

adult Malpighian tubule principal cell

(Söderberg et al., 2011)

(Söderberg et al., 2011)

Additional Descriptive Data

Expression of Ilp5 in dorsomedial neurosecretory cells increases in first instar larvae and remains high in second and third instar larvae.

(Okamoto and Nishimura, 2015)

Ilp5 is expressed in a bilaterally symmetrical cluster of 5 to 7 neurosecretory cells in the pars intercerebralis. It is co-expressed with Ilp3 and Ilp2.

(Broughton et al., 2005)

Transcript is expressed in two clusters of cells in the pars intercerebralis corresponding to the medial neurosecretory cell clusters (m-NSCs) from the mid-late third larval instar.

(Ikeya et al., 2002)

Transcript is detected at high levels in seven cells in each brain hemisphere in an anterior-medial postion and at low levels in the gut.

(Brogiolo et al., 2001)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval insulin secreting cell of pars intercerebralis

(Liu et al., 2016, Garelli et al., 2015)

embryonic/larval Malpighian tubule Type I cell

(Söderberg et al., 2011)

embryonic/larval corpus cardiacum

(Garelli et al., 2015)

prepupal stage P1 -- pupal stage P7

insulin secreting cell of pars intercerebralis

(Liu et al., 2016)

pharate adult stage P8 -- adult stage

adult insulin secreting cell of pars intercerebralis

(Liu et al., 2016)

adult Malpighian tubule principal cell

(Söderberg et al., 2011)

Additional Descriptive Data

Ilp5-XP is present in the ring gland projections of the larval dorsomedial neurosecretory cells.

(Garelli et al., 2015)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Sajid et al., 2011)

Expression Deduced from Reporters

Reporter: P{Ilp5-GAL4.L}

Stage

Tissue/Position (including subcellular localization)

Reference

larval insulin secreting cell of pars intercerebralis

(Liu et al., 2016)

adult insulin secreting cell of pars intercerebralis

(Liu et al., 2016)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ilp5 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ilp5

View exonic expression by tissue for Dmel\Ilp5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768992/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0044048

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0044048

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0044048

Flygut - An atlas of the Drosophila adult midgut

FBgn0044048

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ilp5

Transgenic constructs containing regulatory region of Ilp5

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

(Brogiolo et al., 2001)

(Zhang et al., 2009)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

Ilp5¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ilp5^GD16039

viable, with Scer\GAL4^Mef2.PR

Ilp5^GD16039

viable, with Scer\GAL4^pnr-MD237

Ilp5^GD16039

Other Phenotypes

Allele

abnormal developmental rate, with Df(3L)Ilp2-3

Ilp5³

abnormal locomotor behavior | adult stage

Ilp5¹

abnormal locomotor behavior | adult stage, with Df(3L)Ilp2-3

Ilp5¹

abnormal mating

Ilp5¹

abnormal size, with Df(3L)Ilp2-3

Ilp5³

abnormal sleep, with Df(3L)Ilp2-3

Ilp5¹

abnormal starvation stress response | adult stage, with Scer\GAL4^elav-C155

Ilp5^UAS.cUa

chemical resistant, with Scer\GAL4^Ilp2.PR

Ilp5^UAS.cIa

decreased fecundity

Ilp5¹

decreased sleep | adult stage

Ilp5¹

decreased sleep | adult stage, with Df(3L)Ilp2-3

Ilp5¹

increased body size, with Scer\GAL4^arm.PS

Ilp5^UAS.cIa

increased occurrence of cell division | second instar larval stage, with Scer\GAL4^repo.PU

Ilp5^UAS.cIa

Ilp5¹

long lived, with Df(3L)Ilp2-3

Ilp5¹

Phenotype manifest in

Allele

larval neuroblast, with Scer\GAL4^repo.PU

Ilp5^UAS.cIa

wing, with Df(3L)Ilp2-3

Ilp5³

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

2 of 14

Yes

Yes

2 of 14

Yes

Yes

1 of 14

No

Yes

6

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

3 of 14

Yes

Yes

2 of 14

No

Yes

2 of 14

No

Yes

1 of 14

No

Yes

Mus musculus (laboratory mouse) (4)

3 of 14

Yes

Yes

2 of 14

No

Yes

2 of 14

No

Yes

1 of 14

No

Yes

Xenopus tropicalis (Western clawed frog) (4)

2 of 13

Yes

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

Danio rerio (Zebrafish) (7)

4 of 14

Yes

Yes

4 of 14

Yes

Yes

3 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

Drer\LOC100534937

1 of 14

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

2 of 14

Yes

Yes

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP010600

4 of 12

Yes

Yes

Agam\AgaP_AGAP010601

2 of 12

No

No

Agam\AgaP_AGAP010602

2 of 12

No

No

Agam\AgaP_AGAP010603

2 of 12

No

No

Agam\AgaP_AGAP010604

2 of 12

No

No

Agam\AgaP_AGAP010605

2 of 12

No

No

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ilp5. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

5 of 13

5 of 13

3 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

diabetes mellitus type 1, insulin peptide deficiency

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

model of sleep disorder

CEA

(Metaxakis et al., 2014)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

ameliorates cancer

modeled by scrib¹

(Sanaki et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

On

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

x-ray crystallography, dynamic light scattering

(Sajid et al., 2011)

competition binding, anti tag coimmunoprecipitation, anti tag western blot, surface plasmon resonance, predetermined participant, x-ray crystallography, cross-linking study, isothermal titration calorimetry, far western blotting

(Roed et al., 2018, Okamoto et al., 2013, Alic et al., 2011, Sajid et al., 2011)

competition binding, electron microscopy

(Viola et al., 2023, Sajid et al., 2011)

anti tag coimmunoprecipitation, anti tag western blot

(Okamoto et al., 2013)

anti tag coimmunoprecipitation, anti tag western blot

(Arquier et al., 2008)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Park et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Mann et al., 2012)

suppressible

(Lv et al., 2024)

suppressible

(Lv et al., 2024)

suppressible

(Saedi et al., 2024)

suppressible

(Parisi et al., 2013)

suppressible

(Okada et al., 2023)

suppressible

(Okada et al., 2023)

External Data

Subunit Structure (UniProtKB)

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

(UniProt, Q7KUD5 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0044048

MIST (protein-protein) - An integrated Molecular Interaction Database

2768992

Pathways

Signaling Pathways (FlyBase)

Insulin-like Receptor Signaling Pathway Core Components

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Insulin signaling pathway

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7KUD5

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-31

Cytogenetic map

Sequence location

3L:9,823,349..9,823,897 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67C9-67C9

Limits computationally determined from genome sequence between P{PZ}fry⁰²²⁴⁰ and P{lacW}l(3)L0539^L0539&P{PZ}Dhh1^rL562 67C9

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-31

(FlyBase, 2016)

3-24.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Aberrations including deletions of this gene Aberrations including duplications of this gene

66007

w^*; P{Ilp5-GAL4.L}8

30884

w¹¹¹⁸; TI{TI}Ilp5¹

75324

w¹¹¹⁸; P{VT028277-p65.AD}attP40

75300

w¹¹¹⁸; P{VT028277-GAL4.DBD}attP2

31378

y¹ v¹; P{TRiP.JF01347}attP2

66008

w^*; P{Ilp5-GAL4.L}3/TM3, Sb¹

88985

w¹¹¹⁸; P{VT050239-p65.AD}attP40; P{VT028277-GAL4.DBD}attP2

15868

P{VT028277-lexA}attP40

HMS00548

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00548}attP2

v49519

P{GD16039}v49519

v105004

P{KK112762}VIE-260B

v49520

w¹¹¹⁸; P{GD16039}v49520

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0044048

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0044048

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Alassaf and Rajan, 2023, Ghosh et al., 2022, Texada et al., 2022, Buhler et al., 2018, Hasygar and Hietakangas, 2014, Söderberg et al., 2011, Broughton et al., 2010, Géminard et al., 2009)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG33273) in release 3.2 of the genome annotation.

(FlyBase Genome Annotators, 2004)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (33)

Reported As

Symbol Synonym

CG33273

(Mao et al., 2024, Rovenko et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008)

DILP

(Wu et al., 2005, Nijhout, 2003, Nijhout, 2003)

DILP 5

(Das and Arur, 2017, Nässel et al., 2015)

DILP-5

(Kim et al., 2023, Slankster et al., 2020, Inoue et al., 2018, Nassel, 2002)

DILPs

(Grenier and Leulier, 2020, Lee et al., 2020)

Dilp

(Rhea et al., 2007, Bradley and Leevers, 2003)

Dilp 5

(P et al., 2020, Macedo et al., 2017, Claeys et al., 2002)

Dilp-5

(Hoshizaki and Gibbs, 2007)

Dilp1-5

(Miao et al., 2022)

Dilp5

(Chen et al., 2024, McPherson et al., 2024, Yoon et al., 2024, Meng et al., 2023, Okada et al., 2023, Tuo et al., 2023, Yang et al., 2023, Bhanja et al., 2022, Du et al., 2022, Eickelberg et al., 2022, He et al., 2022, Zhou et al., 2022, Han et al., 2021, Kannangara et al., 2021, Moraes and Montagne, 2021, Wu et al., 2021, Tang et al., 2020, Texada et al., 2020, Wang et al., 2020, Deveci et al., 2019, May et al., 2019, Meschi et al., 2019, Ryu et al., 2019, Texada et al., 2019, Buhler et al., 2018, Liu and Jin, 2017, Rajan et al., 2017, Droujinine and Perrimon, 2016, Zheng et al., 2016, Garelli et al., 2015, Kwon et al., 2015, Rovenko et al., 2015, Suh et al., 2015, Andersen et al., 2013, Gimenez et al., 2013, Kwak et al., 2013, Nässel et al., 2013, Okamoto et al., 2013, Hong et al., 2012, Kapan et al., 2012, Rajan and Perrimon, 2012, Birse et al., 2011, Demontis and Perrimon, 2010, Géminard et al., 2009, Wang et al., 2009, Arquier et al., 2008, Lee et al., 2008)

ILP5

(Pragati and Sarkar, 2024, Chowański et al., 2021, Schoberleitner et al., 2021, Sciambra and Chtarbanova, 2021, Polan et al., 2020, Huang et al., 2019, Ahmad et al., 2018, Warren et al., 2017, Barber et al., 2016, Koyama and Mirth, 2016, Homem et al., 2014, Koyama et al., 2013, Papatheodorou et al., 2012, Hahn et al., 2010)

ILPs

(Zhao and Karpac, 2020)

Ilp

(Maistrenko et al., 2016, Edgar, 2006)

Ilp-5

(Hersperger et al., 2024, Pospisilik et al., 2010, Veenstra et al., 2008)

Ilp5

(Singh et al., 2024, Hu et al., 2023, Lovegrove et al., 2023, Sanz et al., 2023, Chen et al., 2022, Deshpande et al., 2022, Dvořáček et al., 2022, Laskowski et al., 2022, Alvarez-Ochoa et al., 2021, Ceder et al., 2021, Destalminil-Letourneau et al., 2021, de Tredern et al., 2021, Fabian et al., 2021, Keith et al., 2021, Lee et al., 2021, Parra-Peralbo et al., 2021, Ceder et al., 2020, Kierdorf et al., 2020, Neamtu et al., 2020, Brunet Avalos et al., 2019, Castillo-Quan et al., 2019, Lin et al., 2019, Mele and Johnson, 2019, Mirth et al., 2019, Croset et al., 2018, Gáliková and Klepsatel, 2018, Ueda et al., 2018, Tain et al., 2017, Wang et al., 2017, Cao et al., 2016, Crocker et al., 2016, Watanabe and Sakai, 2016, Wiemerslage et al., 2016, Williams et al., 2016, Alfa et al., 2015, Dialynas et al., 2015, Lee et al., 2015, Wagner et al., 2015, Williams et al., 2015, Woodcock et al., 2015, Metaxakis et al., 2014, Park et al., 2014, Okamoto et al., 2013, Sopko and Perrimon, 2013, Walker et al., 2013, Papatheodorou et al., 2012, Thomas et al., 2012, Sousa-Nunes et al., 2011, Gronke, 2010.5.12, Kühnlein, 2010, InterPro Project Members, 2004-)

dILP-5

(Biglou et al., 2021, Ecker et al., 2017, Teleman and Cohen, 2006)

dIlp5

(De Groef et al., 2024, Bonfini et al., 2016, Aradhya et al., 2015, Boyd et al., 2011)

dilp

(Belawat and Hafen, 2005)

dilp-5

(Banerjee et al., 2013, Wu and Brown, 2006, Hwangbo et al., 2004)

dilp5

(Huang et al., 2024, Lee and Min, 2024, Meng et al., 2024, Gupta et al., 2023, Gupta et al., 2023, Lee et al., 2023, Li et al., 2023, Rodrigues et al., 2023, Duarte et al., 2022, Sano et al., 2022, Wang et al., 2022, Winant et al., 2022, Yan et al., 2022, Atilano et al., 2021, Clements et al., 2021, Cox et al., 2021, De Groef et al., 2021, Ganguly et al., 2021, Kim et al., 2021, Liao et al., 2021, Meschi and Delanoue, 2021, Millington et al., 2021, Pathak and Varghese, 2021, Prince et al., 2021, Semaniuk et al., 2021, Takechi et al., 2021, Yang et al., 2021, Yoshinari et al., 2021, Ingaramo et al., 2020, Liao et al., 2020, Ma et al., 2020, Manière et al., 2020, Miller et al., 2020, Sanaki et al., 2020, Strilbytska et al., 2020, Strilbytska et al., 2020, Strilbytska et al., 2020, Sudhakar et al., 2020, Wilson et al., 2020, Castillo-Quan et al., 2019, Katsube et al., 2019, Trinh et al., 2019, Zheng et al., 2019, Galagovsky et al., 2018, Henstridge et al., 2018, Lin et al., 2018, Semaniuk et al., 2018, Kang et al., 2017, Liao et al., 2017, Schoofs et al., 2017, Tiku et al., 2017, Zandveld et al., 2017, Hallier et al., 2016, Kubrak et al., 2016, Kučerová et al., 2016, Liu et al., 2016, Schiesari et al., 2016, Wang et al., 2016, Ismail et al., 2015, Kawasaki et al., 2015, Kohyama-Koganeya et al., 2015, Li and Gong, 2015, Matsuda et al., 2015, Pasco et al., 2015, Sano et al., 2015, Yan et al., 2015, Gündner et al., 2014, Piper et al., 2014, Whitaker et al., 2014, Guirao-Rico and Aguadé, 2013, Hur et al., 2013, Kannan and Fridell, 2013, Karpac et al., 2013, Parisi et al., 2013, Yamamoto et al., 2013, Bai et al., 2012, Banerjee et al., 2012, Kayashima et al., 2012, Mann et al., 2012, Marshall et al., 2012, Rideout et al., 2012, Yu et al., 2012, Alic et al., 2011, Guirao-Rico and Aguadé, 2011, Karpac et al., 2011, McClure et al., 2011, Partridge et al., 2011, Sheldon et al., 2011, Slack et al., 2011, Söderberg et al., 2011, Wigby et al., 2011, De Luca et al., 2010, Grönke et al., 2010, Haselton et al., 2010, Sekine et al., 2010, Slack et al., 2010, Fridell et al., 2009, Hull-Thompson et al., 2009, Humphrey et al., 2009, Karpac et al., 2009, Okamoto et al., 2009, Zhang et al., 2009, Broughton et al., 2008, Buch et al., 2008, Clements et al., 2008, Flatt et al., 2008, Wang et al., 2008, Giannakou et al., 2007, Libert, 2007, Mattaliano et al., 2007, Min et al., 2007, Broughton et al., 2005, Flatt et al., 2005, Tatar et al., 2003, Ikeya and Hafen, 2002, Ikeya et al., 2002, Rulifson et al., 2002, Brogiolo et al., 2001)

dipl5

(Kakanj et al., 2016)

dlp

(Mira and Morante, 2020)

ilp5

(Banzai and Nishimura, 2023, Palu et al., 2022, Newell et al., 2020, Dhiman et al., 2019, Liu et al., 2018, Musashe et al., 2016, Yurgel et al., 2015, Song et al., 2010, Varghese et al., 2010, Kim et al., 2008, Min et al., 2008, Wang et al., 2008)

Name Synonyms

Drosophila insulin-like peptide 5

(Oldham and Hafen, 2003)

Insulin-like peptide

(Maistrenko et al., 2016)

Insulin-like peptide 5

insulin like peptide 5

(Dalton et al., 2010)

insulin-like peptide

(Flatt et al., 2005)

insulin-like peptide 5

(Brogiolo et al., 2001)

insulin-like peptide-5

(Min et al., 2008)

insulin/insulin-like growth factor

(Quigley and Amdam, 2021)

Secondary FlyBase IDs

FBgn0053273

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

2768992

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAS65048

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

NM_206315

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KUD5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7KUD5

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KUD5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768992/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0044048

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0044048

FlyMine - An integrated database for Drosophila genomics

FBgn0044048

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33273

MARRVEL_MODEL - MARRVEL (model organism gene)

2768992

PDB - An information portal to biological macromolecular structures

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0044048

DroID - A comprehensive database of gene and protein interactions.

FBgn0044048

DRSC - Results frm RNAi screens

FBgn0044048

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ilp5_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0044048

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0044048

Flygut - An atlas of the Drosophila adult midgut

FBgn0044048

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

2768992

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Insulin signaling pathway

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7KUD5

References (436)