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Gene Dmel\Ilp5

General Information
Symbol	Dmel\Ilp5	Species	D. melanogaster
Name	Insulin-like peptide 5	Annotation symbol	CG33273
Feature type	protein_coding_gene	FlyBase ID	FBgn0044048
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	dilp5, DILP, dILP-5, Ilp-5
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67C9-67C9	Sequence location	3L:9,816,449..9,816,997 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Insulin-like peptide 5 is referred to in FlyBase by the symbol Dmel\Ilp5 (CG33273, FBgn0044048). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: insulin receptor binding. There is experimental evidence that it is involved in the biological process: female mating behavior. 9 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval neuroblast. It has one annotated transcript and one annotated polypeptide. Protein features are: Insulin family; Insulin, conserved site; Insulin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1624745_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ilp5. Gene sequence location is 3L:9816449..9816997.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Shin et al., 2011, Science 334(6056): 670--674 O'Brien et al., 2011, Cell 147(3): 603--614 Dalton et al., 2010, BMC Genomics 11: 541 Sequence features BKN32762 HFA08998 BKN45911
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C9-67C9   Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562 67C9
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ilp5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	This gene model is based on information reported in FBrf0134520 and a low scoring genscan gene prediction.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ilp5-RA FBtr0076371  NM_206315   478   107
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ilp5-PA   FBpp0076100   11.8   107   7.80     NP_996037   AAS65048
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Insulin-like (IPR016179) Insulin family (IPR022352) Insulin, conserved site (IPR022353)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAS65048   BT032927   BT032948
UniProtKB/Swiss-Prot	Q7KUD5
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference second instar larval stage -- third instar larval stage   dorsomedial neurosecretory cell of pars intercerebralis   (Ikeya et al., 2002) third instar larval stage   embryonic/larval brain | anterior & medial & restricted   (Brogiolo et al., 2001) embryonic/larval midgut   (Brogiolo et al., 2001)
Additional Descriptive Data
	Transcript is detected at high levels in seven cells in each brain hemisphere in an anterior-medial postion and at low levels in the gut. (Brogiolo et al., 2001) Transcript is expressed in two clusters of cells in the pars intercerebralis corresponding to the medial neurosecretory cell clusters (m-NSCs) from the mid-late third larval instar. (Ikeya et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0044048    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0044048 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0044048 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1    106 larva L2    319 larva L3 12hr old    487 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    287 larva L3 puffstage 7-9    501 white prepupae new    557 white prepupae 12hr    423 white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP    283 adult male 01day    273 adult male 05day    339 adult male 30day    477 adult female 01day    200 adult female 05day    101 adult female 30day    162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1  106 larva L2  (319) larva L3 12hr old  (487) larva L3 puffstage 1-2  (333) larva L3 puffstage 3-6  (287) larva L3 puffstage 7-9  (501) white prepupae new  (557) white prepupae 12hr  (423) white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP  (283) adult male 01day  (273) adult male 05day  (339) adult male 30day  (477) adult female 01day  (200) adult female 05day  101 adult female 30day  (162) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1    106 larva L2    319 larva L3 12hr old    487 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    287 larva L3 puffstage 7-9    501 white prepupae new    557 white prepupae 12hr    423 white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP    283 adult male 01day    273 adult male 05day    339 adult male 30day    477 adult female 01day    200 adult female 05day    101 adult female 30day    162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1    106 larva L2    319 larva L3 12hr old    487 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    287 larva L3 puffstage 7-9    501 white prepupae new    557 white prepupae 12hr    423 white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP    283 adult male 01day    273 adult male 05day    339 adult male 30day    477 adult female 01day    200 adult female 05day    101 adult female 30day    162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1    106 larva L2    319 larva L3 12hr old    487 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    287 larva L3 puffstage 7-9    501 white prepupae new    557 white prepupae 12hr    423 white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP    283 adult male 01day    273 adult male 05day    339 adult male 30day    477 adult female 01day    200 adult female 05day    101 adult female 30day    162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0044048 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1    106 larva L2    319 larva L3 12hr old    487 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    287 larva L3 puffstage 7-9    501 white prepupae new    557 white prepupae 12hr    423 white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP    283 adult male 01day    273 adult male 05day    339 adult male 30day    477 adult female 01day    200 adult female 05day    101 adult female 30day    162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1  106 larva L2  (319) larva L3 12hr old  (487) larva L3 puffstage 1-2  (333) larva L3 puffstage 3-6  (287) larva L3 puffstage 7-9  (501) white prepupae new  (557) white prepupae 12hr  (423) white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP  (283) adult male 01day  (273) adult male 05day  (339) adult male 30day  (477) adult female 01day  (200) adult female 05day  101 adult female 30day  (162) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1    106 larva L2    319 larva L3 12hr old    487 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    287 larva L3 puffstage 7-9    501 white prepupae new    557 white prepupae 12hr    423 white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP    283 adult male 01day    273 adult male 05day    339 adult male 30day    477 adult female 01day    200 adult female 05day    101 adult female 30day    162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1    106 larva L2    319 larva L3 12hr old    487 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    287 larva L3 puffstage 7-9    501 white prepupae new    557 white prepupae 12hr    423 white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP    283 adult male 01day    273 adult male 05day    339 adult male 30day    477 adult female 01day    200 adult female 05day    101 adult female 30day    162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    2 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    8 embryo 14-16hr    22 embryo 16-18hr    11 embryo 18-20hr    30 embryo 20-22hr    10 embryo 22-24hr    16 larva L1    106 larva L2    319 larva L3 12hr old    487 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    287 larva L3 puffstage 7-9    501 white prepupae new    557 white prepupae 12hr    423 white prepupae 24hr    42 pupae 2d postWPP    83 pupae 3d postWPP    50 pupae 4d postWPP    283 adult male 01day    273 adult male 05day    339 adult male 30day    477 adult female 01day    200 adult female 05day    101 adult female 30day    162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0044048    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0044048 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0044048 expression level Tissue   Expression Level Larval Central Nervous System    630.75 Larval Midgut    9.1 Larval Hindgut    8.7 Larval Malpighian Tubules    286.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    4.3 Larval Carcass no informative data Adult Head    184.8 Adult Eye    4.775 Adult Brain    683 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    9.8 Adult Midgut    12 Adult Hindgut    7 Adult Malpighian Tubules no informative data Adult Fat Body    8.8 Adult Salivary Gland no informative data Adult Heart    2.925 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    4.4 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (630.75) Larval Midgut    9.1 Larval Hindgut    8.7 Larval Malpighian Tubules    286.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    4.3 Larval Carcass no informative data Adult Head    184.8 Adult Eye    4.775 Adult Brain  (683) Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    9.8 Adult Midgut    12 Adult Hindgut    7 Adult Malpighian Tubules no informative data Adult Fat Body    8.8 Adult Salivary Gland no informative data Adult Heart    2.925 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    4.4 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    630.75 Larval Midgut    9.1 Larval Hindgut    8.7 Larval Malpighian Tubules    286.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    4.3 Larval Carcass no informative data Adult Head    184.8 Adult Eye    4.775 Adult Brain    683 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    9.8 Adult Midgut    12 Adult Hindgut    7 Adult Malpighian Tubules no informative data Adult Fat Body    8.8 Adult Salivary Gland no informative data Adult Heart    2.925 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    4.4 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    630.75 Larval Midgut    9.1 Larval Hindgut    8.7 Larval Malpighian Tubules    286.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    4.3 Larval Carcass no informative data Adult Head    184.8 Adult Eye    4.775 Adult Brain    683 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    9.8 Adult Midgut    12 Adult Hindgut    7 Adult Malpighian Tubules no informative data Adult Fat Body    8.8 Adult Salivary Gland no informative data Adult Heart    2.925 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    4.4 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0044048 expression level Tissue   Expression Level Larval Central Nervous System    630.75 Larval Midgut    9.1 Larval Hindgut    8.7 Larval Malpighian Tubules    286.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    4.3 Larval Carcass no informative data Adult Head    184.8 Adult Eye    4.775 Adult Brain    683 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    9.8 Adult Midgut    12 Adult Hindgut    7 Adult Malpighian Tubules no informative data Adult Fat Body    8.8 Adult Salivary Gland no informative data Adult Heart    2.925 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    4.4 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  630.75 Larval Midgut    9.1 Larval Hindgut    8.7 Larval Malpighian Tubules    286.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    4.3 Larval Carcass no informative data Adult Head    184.8 Adult Eye    4.775 Adult Brain  683 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    9.8 Adult Midgut    12 Adult Hindgut    7 Adult Malpighian Tubules no informative data Adult Fat Body    8.8 Adult Salivary Gland no informative data Adult Heart    2.925 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    4.4 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    630.75 Larval Midgut    9.1 Larval Hindgut    8.7 Larval Malpighian Tubules    286.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    4.3 Larval Carcass no informative data Adult Head    184.8 Adult Eye    4.775 Adult Brain    683 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    9.8 Adult Midgut    12 Adult Hindgut    7 Adult Malpighian Tubules no informative data Adult Fat Body    8.8 Adult Salivary Gland no informative data Adult Heart    2.925 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    4.4 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    630.75 Larval Midgut    9.1 Larval Hindgut    8.7 Larval Malpighian Tubules    286.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    4.3 Larval Carcass no informative data Adult Head    184.8 Adult Eye    4.775 Adult Brain    683 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    9.8 Adult Midgut    12 Adult Hindgut    7 Adult Malpighian Tubules no informative data Adult Fat Body    8.8 Adult Salivary Gland no informative data Adult Heart    2.925 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    4.4 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    184.8   NA  Eye    4.775   NA  Brain    683   630.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.5   NA  Crop    9.8   9.1  Midgut    12   8.7  Hindgut    7   286.1  Malpighian Tubules    no informative data   no informative data  Fat Body    8.8   no informative data  Salivary Gland    no informative data   NA  Heart    2.925   4.3  Trachea    NA   NA  VirginFemale Spermatheca    8.8   NA  InseminatedFemale Spermatheca    5.7   NA  Ovary    4.4   NA  Testis    6.5   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0044048 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • HDC09365
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Ilp51 viable, with Scer\GAL4pnr-MD237 Ilp5GD16039 Other Phenotypes Allele large body, with Scer\GAL4arm.PS Ilp5Scer\UAS.cIa mating defective Ilp51 Phenotype manifest in Allele embryonic/larval neuroblast, with Scer\GAL4repo.PU Ilp5Scer\UAS.cIa
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Ilp5 Class Mutagen Stocks Known lesion Ilp53 SCEI endonuclease FLPase 3 Yes Ilp54 SCEI endonuclease FLPase 3 Yes Ilp51 SCEI endonuclease FLPase 1 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ilp5 Class Mutagen Stocks Known lesion Ilp5GD16039 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp5HMS00548 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp5JF01347 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp5KK112762 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp5Scer\UAS.cIa in vitro construct - regulatory fusion 0 Yes Ilp5w.Scer\SceI.RS in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)AC1 (Brogiolo et al., 2001) Df(3L)Ilp1-5 (Zhang et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD16039} NA P{KK112762} NA P{TRiP.HMS00548} NA P{TRiP.JF01347} NA P{UAS-Ilp5.I} NA reporter construct P{pXD51X} No P{pXD51XB} No
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
female mating behavior inferred from mutant phenotype (Wigby et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
hormone activity inferred from electronic annotation with InterPro:IPR016179 (FlyBase Curators et al., 2004-) insulin receptor binding inferred from sequence or structural similarity with human INS (Brogiolo et al., 2001) inferred from sequence or structural similarity with UniProtKB:P22334 (FlyBase Genome Annotators, 2004)
Biological Process
CV term Evidence References
insulin receptor signaling pathway inferred from sequence or structural similarity with human INS (Brogiolo et al., 2001)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity with human INS (Brogiolo et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ilp5 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0044048 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768992
Orthologs
Genome-wide drosophilid orthologs	Dere\GG14004 Dgri\GH16013 Dmoj\GI12279 Dper\GL16323 Dpse\GA23860 Dsec\GM24838 Dsim\GD12890 Dvir\GJ13215 Dyak\GE20299
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_001949438.1 Acyrthosiphon pisum (pea aphid) 77763 Branchiostoma floridae (lancelet) 300602 Daphnia pulex (daphnia) ENSDARP00000042849 Danio rerio (zebra fish) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14266 LH15531 FBgn0238965 FBgn0237618 FBgn0212990 FBgn0200441 FBgn0199380 FBgn0185903 FBgn0184615 FBgn0180045 FBgn0179700 JGI_V11_300602 FBgn0245259 FBgn0072849 FBgn0153927 FBgn0153899 FBgn0135790 FBgn0135036 FBgn0044051 FBgn0123484 FBgn0122903 FBgn0107662 FBgn0106266 FBgn0101670 FBgn0097107 CPIJ018049 BGIBMGA014496 BGIBMGA014494 BGIBMGA014495 BGIBMGA014205 BGIBMGA012476 BGIBMGA012305 BGIBMGA012293 BGIBMGA012294 BGIBMGA011972 BGIBMGA011969 BGIBMGA011968 BGIBMGA011930 BGIBMGA011928 BGIBMGA011929 ACYPI54347 ACYPI53158 ACYPI45823 GB10174 AGAP010600 AGAP010601 AAEL000973 PB25489 GLEAN_08479 GLEAN_07035
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	30884 w1118; Ilp51 31378 y1 v1; P{TRiP.JF01347}attP2 33683 y1 sc* v1; P{TRiP.HMS00548}attP2 30889 w1118; Df(3L)Ilp2-3, Ilp53/TM3, Sb1 30890 w1118; Df(3L)Ilp1-4, Ilp54/TM3, Sb1 30893 w1118 Ilp71; Df(3L)Ilp2-3, Ilp53/TM3, Sb1 30894 w1118 Ilp71; Df(3L)Ilp1-4, Ilp54/TM3, Sb1 30891 Df(1)Ilp668, y1 phl68 w1118; Df(3L)Ilp2-3, Ilp53/TM3, Sb1 30892 Df(1)Ilp641, y1 Ilp641 phl41 w1118; Df(3L)Ilp2-3, Ilp54/TM3, Sb1
VDRC	v105004 P{KK112762}VIE-260B v49520 w1118; P{GD16039}v49520
Genomic Clones ( 2 )
	BACR07A05 BACR07E07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	IP20266 IP20566
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0044048 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768992
Antibody Information
	polyclonal (Broughton et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	New annotation (CG33273) in release 3.2 of the genome annotation. (FlyBase Genome Annotators, 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206315 RefSeq (Proteins) • NP_996037 DDBJ / EMBL / GenBank • AAS65048 Entrez Gene - A searchable database of RefSeq genes. • 2768992 UniProtKB/Swiss-Prot • Q7KUD5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Insulin-like (IPR016179) Insulin family (IPR022352) Insulin, conserved site (IPR022353)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0044048 DRSC - Results from RNAi screens. • FBgn0044048 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0044048 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • HDC09365 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0044048 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768992 InParanoid A subset of ortholog calls from InParanoid. • XP_001949438.1 Acyrthosiphon pisum (pea aphid) 77763 Branchiostoma floridae (lancelet) 300602 Daphnia pulex (daphnia) ENSDARP00000042849 Danio rerio (zebra fish) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768992 modMine - Data generated by the modENCODE project. • FBgn0044048 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14266 LH15531 FBgn0238965 FBgn0237618 FBgn0212990 FBgn0200441 FBgn0199380 FBgn0185903 FBgn0184615 FBgn0180045 FBgn0179700 JGI_V11_300602 FBgn0245259 FBgn0072849 FBgn0153927 FBgn0153899 FBgn0135790 FBgn0135036 FBgn0044051 FBgn0123484 FBgn0122903 FBgn0107662 FBgn0106266 FBgn0101670 FBgn0097107 CPIJ018049 BGIBMGA014496 BGIBMGA014494 BGIBMGA014495 BGIBMGA014205 BGIBMGA012476 BGIBMGA012305 BGIBMGA012293 BGIBMGA012294 BGIBMGA011972 BGIBMGA011969 BGIBMGA011968 BGIBMGA011930 BGIBMGA011928 BGIBMGA011929 ACYPI54347 ACYPI53158 ACYPI45823 GB10174 AGAP010600 AGAP010601 AAEL000973 PB25489 GLEAN_08479 GLEAN_07035
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	CG33273 (Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2010.12.1, Nairz et al., 2004) DILP (Wu et al., 2005, Nijhout, 2003, Nijhout, 2003) dilp (Belawat and Hafen, 2005) Dilp (Bradley and Leevers, 2003, Rhea et al., 2007) dILP-5 (Teleman and Cohen, 2006) dilp5 (Broughton et al., 2005, Tatar et al., 2003, Ikeya et al., 2002, Rulifson et al., 2002, Ikeya and Hafen, 2002, Brogiolo et al., 2001, Min et al., 2007, Flatt et al., 2005, Libert, 2007, Karpac et al., 2009, Mattaliano et al., 2007, Slack et al., 2010, Flatt et al., 2008, Broughton et al., 2008, Humphrey et al., 2009, Buch et al., 2008, Okamoto et al., 2009, Clements et al., 2008, Hull-Thompson et al., 2009, Giannakou et al., 2007, Zhang et al., 2009, Grönke et al., 2010, De Luca et al., 2010, Sekine et al., 2010, Wigby et al., 2011, Alic et al., 2011, Wang et al., 2008, McClure et al., 2011) dilp-5 (Hwangbo et al., 2004) Dilp 5 (Claeys et al., 2002) DILP5 (Leevers, 2001, Slaidina et al., 2009, Broughton et al., 2010, Sajid et al., 2011, Nairz et al., 2004) Dilp-5 (Hoshizaki and Gibbs, 2007) Dilp5 (Lee et al., 2008, Wang et al., 2009, Arquier et al., 2008, Demontis and Perrimon, 2010) dILP5 (Teleman et al., 2008) dIlp5 (Boyd et al., 2011) Ilp (Edgar, 2006) Ilp5 (FlyBase Curators et al., 2004-, Cook, 2010.5.12, Sousa-Nunes et al., 2011) ilp5 (Song et al., 2010, Xu et al., 2008, Min et al., 2008, Varghese et al., 2010, Wang et al., 2008) Ilp-5 (Veenstra et al., 2008, Pospisilik et al., 2010) ILP5 (Hahn et al., 2010)
Name Synonym	Drosophila insulin-like peptide 5 (Oldham and Hafen, 2003) insulin-like peptide (Flatt et al., 2005) insulin-like peptide 5 (Brogiolo et al., 2001) Insulin-like peptide 5   insulin-like peptide-5 (Min et al., 2008) insulin like peptide 5 (Dalton et al., 2010)
Secondary FlyBase IDs
	FBgn0053273
References ( 74 )
Generate a list of	All references relating to this gene ( 74 )
List References by type	Research paper  ( 47 ) Supplementary material  ( 2 ) Review  ( 11 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) Conference report  ( 2 )
Recent research papers ( 19 )
	Alic et al., 2011, Aging Cell 10(1): 137--147 Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. [FBrf0212768] Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678 Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612] McClure et al., 2011, Dis. Model Mech. 4(3): 335--346 A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway. [FBrf0213698] O'Brien et al., 2011, Cell 147(3): 603--614 Altered modes of stem cell division drive adaptive intestinal growth. [FBrf0216512] Sajid et al., 2011, J. Biol. Chem. 286(1): 661--673 Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation. [FBrf0212648] Shin et al., 2011, Science 334(6056): 670--674 Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling. [FBrf0216582] Sousa-Nunes et al., 2011, Nature 471(7339): 508--512 Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. [FBrf0214426] Wigby et al., 2011, Proc. Biol. Sci. 278(1704): 424--431 Insulin signalling regulates remating in female Drosophila. [FBrf0212666] Broughton et al., 2010, Aging Cell 9(3): 336--346 DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. [FBrf0211116] Dalton et al., 2010, BMC Genomics 11: 541 Dynamic, mating-induced gene expression changes in female head and brain tissues of Drosophila melanogaster. [FBrf0212122] De Luca et al., 2010, PLoS ONE 5(6): e11286 A conserved role for syndecan family members in the regulation of whole-body energy metabolism. [FBrf0211150] Demontis and Perrimon, 2010, Cell 143(5): 813--825 FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging. [FBrf0212347] Grönke et al., 2010, PLoS Genet. 6(2): e1000857 Molecular evolution and functional characterization of Drosophila insulin-like peptides. [FBrf0210097] Hahn et al., 2010, Cell Metab. 11(5): 438--444 PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation. [FBrf0210726] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Sekine et al., 2010, J. Biol. Chem. 285(49): 38684--38691 Blocking O-Linked GlcNAc Cycling in Drosophila Insulin-producing Cells Perturbs Glucose-Insulin Homeostasis. [FBrf0212389] Slack et al., 2010, PLoS Genet. 6(3): e1000881 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. [FBrf0210418] Song et al., 2010, Cell Metab. 11(5): 427--437 SH2B regulation of growth, metabolism, and longevity in both insects and mammals. [FBrf0210745] Varghese et al., 2010, Genes Dev. 24(24): 2748--2753 Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe. [FBrf0212621] Show all research papers ...
Recent reviews ( 1 )
	Teleman, 2010, Biochem. J. 425(1): 13--26 Molecular mechanisms of metabolic regulation by insulin in Drosophila. [FBrf0209514] Show all reviews ...