FB2020_03, released Jun 16, 2020

Gene: Dmel\Ilp3

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General Information
Symbol
Dmel\Ilp3
Species
D. melanogaster
Name
Insulin-like peptide 3
Annotation Symbol
CG14167
Feature Type
protein_coding_gene
FlyBase ID
FBgn0044050
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. [Date last reviewed: 2019-07-11]
Other Summaries
Also Known As

dilp3, Dilp 3, DILP-3, Ilp, Dilp

Key Links
Genomic Location
Cytogenetic map
67C8-67C8
Sequence location
3L:9,801,298..9,802,120 [-]
Recombination map

3-31

RefSeq locus
NT_037436 REGION:9801298..9802120
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
hormone activity
inferred from electronic annotation with InterPro:IPR016179
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
insulin receptor binding
inferred from sequence or structural similarity with HGNC:6081
(Brogiolo et al., 2001)
Biological Process (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
NOT circadian rhythm
inferred from mutant phenotype
(Metaxakis et al., 2014)
female mating behavior
inferred from mutant phenotype
(Wigby et al., 2011)
insulin receptor signaling pathway
inferred from mutant phenotype
(Kim and Neufeld, 2015)
locomotor rhythm
inferred from mutant phenotype
(Metaxakis et al., 2014)
negative regulation of entry into reproductive diapause
inferred from mutant phenotype
(Schiesari et al., 2016)
response to carbohydrate
inferred from expression pattern
(Kim and Neufeld, 2015)
sleep
inferred from mutant phenotype
(Metaxakis et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
insulin receptor signaling pathway
inferred from sequence or structural similarity with UniProtKB:Q9VT51
(assigned by UniProt )
(Brogiolo et al., 2001)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
extracellular space
inferred from direct assay
(Kim and Neufeld, 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
extracellular space
inferred from sequence or structural similarity with HGNC:6081
(Brogiolo et al., 2001)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the insulin family. (Q9VT52)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
NEUROPEPTIDES -
Neuropeptides are secreted into the extracellular space where they interact with cell surface receptors (usually G protein coupled receptors). They are extremely diverse, acting as neurotransmitters, neuromodulators, hormones or growth factors. (Adapted from FBrf0211443 and PMID:27813667).
INSULIN-LIKE PEPTIDES -
The insulin superfamily consists of peptides such as vertebrate insulins, mammalian relaxin and insulin-like growth factors, and invertebrate insulin-like peptides (ILP). They are synthesized as pre-propeptides and processed to yield two peptides, A and B, linked by disulfide bonds. ILPs have been identified throughout invertebrate species. In D.mel, ILPs may function as peptide hormones and/or neuropeptides. They have been linked to the regulation of growth and development. (Adapted from FBrf0189697 and FBrf0152330).
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Ilp3 or the JBrowse view of Dmel\Ilp3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ilp3-RA
FBtr0076373
NM_140103
751
120
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ilp3-PA
FBpp0076102
13.7
120
8.70
NP_648360
AAF50203
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

(UniProt, Q9VT52)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ilp3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval brain | anterior | medial | restricted
(Brogiolo et al., 2001)
adult stage
insulin secreting cell of pars intercerebralis
(Broughton et al., 2005)
late third instar larval stage
insulin secreting cell of pars intercerebralis of larval pars intercerebralis
(Ikeya et al., 2002)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
first instar larval stage
larval insulin secreting cell of pars intercerebralis
(Okamoto and Nishimura, 2015)
second instar larval stage
larval insulin secreting cell of pars intercerebralis
(Okamoto and Nishimura, 2015)
third instar larval stage
larval insulin secreting cell of pars intercerebralis
(Okamoto and Nishimura, 2015)
prepupal stage P3 -- pharate adult stage P15
organism
(Slaidina et al., 2009)
adult stage | male
organism
(Slaidina et al., 2009)
adult stage | female
organism
(Slaidina et al., 2009)
Additional Descriptive Data

Expression of Ilp3 is low in first and second instar larvae and increases sharply during the third instar larval stage.

(Okamoto and Nishimura, 2015)

Ilp3 is expressed in a bilaterally symmetrical cluster of 5 to 7 neurosecretory cells in the pars intercerebralis. It is co-expressed with Ilp2 and Ilp5.

(Broughton et al., 2005)

Transcript is expressed in two clusters of cells in the pars intercerebralis corresponding to the medial neurosecretory cell clusters (m-NSCs) from the second through third larval instars.

(Ikeya et al., 2002)

The transcript is exclusively detected in seven cells in each brain hemisphere in an anterior-medial postion

(Brogiolo et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ilp3 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ilp3
Transgenic constructs containing regulatory region of Ilp3
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
decreased fecundity
large body, with Scer\GAL4arm.PS
mating defective
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\IGF1
1 of 15
Yes
No
Hsap\IGF2
1 of 15
Yes
No
Hsap\INS
1 of 15
Yes
No
3  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Igf1
1 of 15
Yes
No
Mmus\Igf2
1 of 15
Yes
No
Mmus\Ins1
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (3)
Rnor\Igf1
1 of 13
Yes
No
Rnor\Igf2
1 of 13
Yes
No
Rnor\Ins1
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\igf1
1 of 12
Yes
No
Xtro\igf2
1 of 12
Yes
No
Xtro\igf3
1 of 12
Yes
No
Xtro\ins
1 of 12
Yes
No
Danio rerio (Zebrafish) (7)
Drer\ins
2 of 15
Yes
No
Drer\igf1
1 of 15
No
No
Drer\igf2a
1 of 15
No
No
Drer\igf2b
1 of 15
No
No
Drer\igf3
1 of 15
No
No
Drer\insb
1 of 15
No
No
Drer\LOC100534937
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ins-1
2 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190IOL )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003902
Drosophila simulans
Dsim\GD12892
Drosophila sechellia
Dsec\GM24840
Drosophila erecta
Dere\GG14006
Drosophila yakuba
Dyak\GE20301
Drosophila ananassae
Dana\GF25126
Drosophila pseudoobscura pseudoobscura
Dpse\GA23862
Drosophila persimilis
Dper\GL16326
Drosophila virilis
Dvir\GJ13218
Drosophila mojavensis
Dmoj\GI12281
Drosophila grimshawi
Dgri\GH16017
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150F6Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013073
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000932
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0SG3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000667
Bombyx mori
Silkmoth
Bmor\BGIBMGA012476
Danaus plexippus
Monarch butterfly
Dple\DPOGS206157-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012614
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08479
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0H2F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012502
Ixodes scapularis
Black-legged tick
Isca\ISCW020331
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59491.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73532.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73533.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83112.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83113.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70794.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75680.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g06150
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g03320
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300602
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0H56 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ilgf2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Igf1p
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020389
Ciona intestinalis
Vase tunicate
Cint\INS-L1
Gallus gallus
Domestic chicken
Ggal\IGF1
Gallus gallus
Domestic chicken
Ggal\INS
Gallus gallus
Domestic chicken
Ggal\IGF2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ilp1
3 of 10
Ilp2
2 of 10
Ilp5
2 of 10
Ilp6
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser
View in Interactions Browser
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Ilp3 - ImpL2
anti tag coimmunoprecipitation, anti tag western blot
(Okamoto et al., 2013)
Ilp3 - Sdr
anti tag coimmunoprecipitation, anti tag western blot
(Okamoto et al., 2013)
Summary of Genetic Interactions
esyN Network Diagram
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
(UniProt, Q9VT52 )
Linkouts
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Metabolic Pathways
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map

3-31

Cytogenetic map
67C8-67C8
Sequence location
3L:9,801,298..9,802,120 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
67C8-67C8
Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

3-31

(FlyBase, 2016)

3-24.1

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (7)
Genomic Clones (20)
cDNA Clones (3)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Ryu et al., 2019, Buhler et al., 2018, Hasygar and Hietakangas, 2014, Broughton et al., 2010, Veenstra et al., 2008)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: Ilp3 CG14167

      (Brogiolo et al., 2001)
      Additional comments
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 31 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (27)
      Reported As
      Symbol Synonym
      CG14167
      (Rovenko et al., 2015, Fukuoh et al., 2014, Lemaitre and Miguel-Aliaga, 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Brogiolo et al., 2001)
      DILP
      (Nijhout, 2003, Nijhout, 2003)
      DILP 3
      (Das and Arur, 2017, Nässel et al., 2015)
      DILP-3
      (Slankster et al., 2020, Inoue et al., 2018, Nassel, 2002)
      DILP3
      (Nässel et al., 2019, Nie et al., 2019, Jung et al., 2018, Nässel, 2018, Ugrankar et al., 2018, Nässel and Vanden Broeck, 2016, Landayan and Wolf, 2015, Luo et al., 2014, Ferrandon, 2013, Kannan and Fridell, 2013, Miyamoto et al., 2013, Nässel et al., 2013, Musselman et al., 2011, Broughton et al., 2010, Nässel and Winther, 2010, Slaidina et al., 2009, Leevers, 2001)
      Dilp
      (Rhea et al., 2007, Bradley and Leevers, 2003)
      Dilp 3
      (Westfall et al., 2019, Macedo et al., 2017, Claeys et al., 2002)
      Dilp-3
      (Hoshizaki and Gibbs, 2007)
      Dilp3
      (Ryu et al., 2019, Texada et al., 2019, Buhler et al., 2018, Liu and Jin, 2017, Liu and Jin, 2017, Droujinine and Perrimon, 2016, Zheng et al., 2016, Kwon et al., 2015, Rovenko et al., 2015, Suh et al., 2015, Amcheslavsky et al., 2014, Kux and Pitsouli, 2014, Andersen et al., 2013, Gimenez et al., 2013, Kwak et al., 2013, Nässel et al., 2013, Okamoto et al., 2013, Shim et al., 2013, Hong et al., 2012, Kapan et al., 2012, Birse et al., 2011, Wang et al., 2009, Lee et al., 2008)
      ILP3
      (Warren et al., 2017, Barber et al., 2016)
      Ilp
      (Maistrenko et al., 2016, Edgar, 2006)
      Ilp-3
      (Pospisilik et al., 2010, Veenstra et al., 2008)
      Ilp3
      (Brunet Avalos et al., 2019, Castillo-Quan et al., 2019, Lin et al., 2019, Mele and Johnson, 2019, Mirth et al., 2019, Croset et al., 2018, Doupé et al., 2018, Gáliková and Klepsatel, 2018, Rossi and Fernandes, 2018, Gáliková et al., 2017, Tain et al., 2017, Wang et al., 2017, Bahrampour and Thor, 2016, Cao et al., 2016, Crocker et al., 2016, Watanabe and Sakai, 2016, Wiemerslage et al., 2016, Williams et al., 2016, Alfa et al., 2015, Cagin et al., 2015, Chen et al., 2015, Lee et al., 2015, Ma et al., 2015, Williams et al., 2015, Woodcock et al., 2015, Metaxakis et al., 2014, Park et al., 2014, Lemaitre and Miguel-Aliaga, 2013, Marianes and Spradling, 2013, Sopko and Perrimon, 2013, Walker et al., 2013, Papatheodorou et al., 2012, Thomas et al., 2012, Sousa-Nunes et al., 2011, Kühnlein, 2010, Veenstra et al., 2008, FlyBase Curators et al., 2004-)
      dILP-3
      (Ecker et al., 2017, Teleman and Cohen, 2006)
      dILP3
      (Álvarez-Rendón et al., 2018, Koyama and Mirth, 2018, Staats et al., 2018, Brookheart et al., 2017, Mattila and Hietakangas, 2017, Brookheart and Duncan, 2016, Li et al., 2016, Das and Dobens, 2015, Ghosh et al., 2014, Hasygar and Hietakangas, 2014, Schriner et al., 2014, Cheetham and Brand, 2013, Garcia et al., 2013, Mirth and Shingleton, 2012, Wang et al., 2011, Teleman et al., 2008)
      dILp3
      (Jiang et al., 2016)
      dIlp3
      (Bonfini et al., 2016, Boyd et al., 2011)
      dilp
      (Belawat and Hafen, 2005)
      dilp-3
      (Wu and Brown, 2006, Hwangbo et al., 2004)
      dilp3
      (Castillo-Quan et al., 2019, Trinh et al., 2019, Zheng et al., 2019, Lin et al., 2018, Lowenstein and Velazquez-Ulloa, 2018, Semaniuk et al., 2018, Westfall et al., 2018, Andreenkova et al., 2017, Liao et al., 2017, Zandveld et al., 2017, Hallier et al., 2016, Kubrak et al., 2016, Kučerová et al., 2016, Liu et al., 2016, Schiesari et al., 2016, Wang et al., 2016, Hentze et al., 2015, Ismail et al., 2015, Kawasaki et al., 2015, Li and Gong, 2015, Matsuda et al., 2015, Pasco et al., 2015, Sano et al., 2015, Yan et al., 2015, Gündner et al., 2014, Ostojic et al., 2014, Piper et al., 2014, Kannan and Fridell, 2013, Parisi et al., 2013, Yamamoto et al., 2013, Bai et al., 2012, Marella et al., 2012, Yu et al., 2012, Alic et al., 2011, Alic et al., 2011, Guirao-Rico and Aguadé, 2011, Sheldon et al., 2011, Slack et al., 2011, Wigby et al., 2011, De Luca et al., 2010, Grönke et al., 2010, Haselton et al., 2010, Sekine et al., 2010, Slack et al., 2010, Varghese et al., 2010, Fridell et al., 2009, Hull-Thompson et al., 2009, Humphrey et al., 2009, Karpac et al., 2009, Kent et al., 2009, Okamoto et al., 2009, Zhang et al., 2009, Broughton et al., 2008, Buch et al., 2008, Clements et al., 2008, Flatt et al., 2008, Wang et al., 2008, Giannakou et al., 2007, Libert, 2007, Mattaliano et al., 2007, Broughton et al., 2005, Buch et al., 2005, Flatt et al., 2005, Melcher and Pankratz, 2005, Wu et al., 2005, Tatar et al., 2003, Ikeya and Hafen, 2002, Ikeya et al., 2002, Rulifson et al., 2002, Brogiolo et al., 2001)
      dipl3
      (Kakanj et al., 2016)
      ilp3
      (Dhiman et al., 2019, Liu et al., 2018, Musashe et al., 2016, Yurgel et al., 2015, Erion and Sehgal, 2013, Song et al., 2010, Veenstra, 2009, Kim et al., 2008, Min et al., 2008, Wang et al., 2008)
      Name Synonyms
      Drosophila insulin-like peptide 3
      (Oldham and Hafen, 2003)
      Insulin-like peptide
      (Maistrenko et al., 2016)
      Insulin-like peptide 3
      insulin-like peptide
      (Flatt et al., 2005)
      insulin-like peptide 3
      (Rovenko et al., 2015, Amcheslavsky et al., 2014, Zhan et al., 2013, Veenstra, 2009, Brogiolo et al., 2001)
      Secondary FlyBase IDs
      • FBgn0036047
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (271)