FlyBase Gene Report: Dmel\Ilp3

General Information

Symbol

Dmel\Ilp3

Species

D. melanogaster

Name

Insulin-like peptide 3

Annotation Symbol

CG14167

Feature Type

protein_coding_gene

FlyBase ID

FBgn0044050

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

dilp3, Dilp 3, DILP-3, Dilp, Ilp

Key Links

Genomic Location

Cytogenetic map

67C8-67C8

Sequence location

3L:9,801,298..9,802,120 [-]

Recombination map

3-31

RefSeq locus

NT_037436 REGION:9801298..9802120

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables hormone activity

inferred from electronic annotation with InterPro:IPR016179

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables insulin receptor binding

inferred from sequence or structural similarity with HGNC:6081

(Brogiolo et al., 2001)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in female mating behavior

inferred from mutant phenotype

(Wigby et al., 2011)

involved_in insulin receptor signaling pathway

inferred from mutant phenotype

(Kim and Neufeld, 2015)

involved_in locomotor rhythm

inferred from mutant phenotype

(Metaxakis et al., 2014)

involved_in negative regulation of entry into reproductive diapause

inferred from mutant phenotype

(Schiesari et al., 2016)

involved_in response to carbohydrate

inferred from expression pattern

(Kim and Neufeld, 2015)

involved_in sleep

inferred from mutant phenotype

(Metaxakis et al., 2014)

NOT involved_in circadian rhythm

inferred from mutant phenotype

(Metaxakis et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in insulin receptor signaling pathway

inferred from sequence or structural similarity with UniProtKB:Q9VT51

(assigned by UniProt )

(Brogiolo et al., 2001)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Kim and Neufeld, 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from sequence or structural similarity with HGNC:6081

(Brogiolo et al., 2001)

Gene Group (FlyBase)

NEUROPEPTIDES

INSULIN-LIKE PEPTIDES

Pathway (FlyBase)

Insulin-like Receptor Signaling Pathway Core Components

Protein Family (UniProt)

Belongs to the insulin family. (Q9VT52)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NEUROPEPTIDES -: Neuropeptides are secreted into the extracellular space where they interact with cell surface receptors (usually G protein coupled receptors). They are extremely diverse, acting as neurotransmitters, neuromodulators, hormones or growth factors. (Adapted from FBrf0211443 and PMID:27813667).
INSULIN-LIKE PEPTIDES -: The insulin superfamily consists of peptides such as vertebrate insulins, mammalian relaxin and insulin-like growth factors, and invertebrate insulin-like peptides (ILP). They are synthesized as pre-propeptides and processed to yield two peptides, A and B, linked by disulfide bonds. ILPs have been identified throughout invertebrate species. In D.mel, ILPs may function as peptide hormones and/or neuropeptides. They have been linked to the regulation of growth and development. (Adapted from FBrf0189697 and FBrf0152330).

Pathway (FlyBase)

Insulin-like Receptor Signaling Pathway Core Components -: The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ilp3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ilp3-RA

FBtr0076373

NM_140103

751

120

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ilp3-PA

FBpp0076102

13.7

120

8.70

NP_648360

AAF50203

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

(UniProt, Q9VT52)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VT52

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ilp3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ilp3_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval brain | anterior | medial | restricted

(Brogiolo et al., 2001)

late third instar larval stage

insulin secreting cell of pars intercerebralis of larval pars intercerebralis

(Ikeya et al., 2002)

adult stage

insulin secreting cell of pars intercerebralis

(Broughton et al., 2005)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

larval insulin secreting cell of pars intercerebralis

(Okamoto and Nishimura, 2015)

second instar larval stage

larval insulin secreting cell of pars intercerebralis

(Okamoto and Nishimura, 2015)

third instar larval stage

larval insulin secreting cell of pars intercerebralis

(Okamoto and Nishimura, 2015)

prepupal stage P3 -- pharate adult stage P15

organism

(Slaidina et al., 2009)

adult stage | male

organism

(Slaidina et al., 2009)

adult stage | female

organism

(Slaidina et al., 2009)

Additional Descriptive Data

Expression of Ilp3 is low in first and second instar larvae and increases sharply during the third instar larval stage.

(Okamoto and Nishimura, 2015)

Ilp3 is expressed in a bilaterally symmetrical cluster of 5 to 7 neurosecretory cells in the pars intercerebralis. It is co-expressed with Ilp2 and Ilp5.

(Broughton et al., 2005)

Transcript is expressed in two clusters of cells in the pars intercerebralis corresponding to the medial neurosecretory cell clusters (m-NSCs) from the second through third larval instars.

(Ikeya et al., 2002)

The transcript is exclusively detected in seven cells in each brain hemisphere in an anterior-medial postion

(Brogiolo et al., 2001)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval insulin secreting cell of pars intercerebralis

(Vallejo et al., 2015)

third instar larval stage

larval insulin secreting cell of pars intercerebralis

(Liu et al., 2016)

prepupal stage P1 -- pupal stage P7

insulin secreting cell of pars intercerebralis

(Liu et al., 2016)

pharate adult stage P8 -- adult stage

adult insulin secreting cell of pars intercerebralis

(Liu et al., 2016)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Kim and Neufeld, 2015)

Expression Deduced from Reporters

Reporter: P{Ilp3-Gal4.B}

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval insulin secreting cell of pars intercerebralis

(Buch et al., 2008)

adult stage

adult insulin secreting cell of pars intercerebralis

(Slack et al., 2011, Buch et al., 2008)

Reporter: P{Ilp3-GAL4.C}

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval insulin secreting cell of pars intercerebralis

(Vallejo et al., 2015)

Reporter: P{Ilp3-GAL4.V}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval midgut longitudinal visceral muscle of gastric caecum

(Veenstra, 2009)

circular visceral muscle fiber of embryonic/larval anterior midgut

(Veenstra, 2009)

circular visceral muscle fiber of embryonic/larval posterior midgut | anterior

(Veenstra, 2009)

adult stage

endocrine neuron

(Veenstra et al., 2008)

adult midgut circular muscle

(Veenstra et al., 2008)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ilp3 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ilp3

View exonic expression by tissue for Dmel\Ilp3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0044050

DRscDB

39151/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0044050

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14167-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0044050

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ilp3

Transgenic constructs containing regulatory region of Ilp3

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(3L)AC1

(Brogiolo et al., 2001)

Df(3L)Ilp1-4

(Grönke et al., 2010)

Df(3L)Ilp1-5

(Zhang et al., 2009)

Df(3L)Ilp2-3

(Grönke et al., 2010)

Gene duplicated in

Dp(3;3)Walkman-nbs-Ilp

(Wesolowska and Rong, 2013)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Ilp3¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ilp3^GD3866

viable, with Scer\GAL4^Mef2.PR

Ilp3^GD3866

viable, with Scer\GAL4^pnr-MD237

Ilp3^GD3866

Other Phenotypes

Allele

abnormal mating

Ilp3¹

decreased fecundity

Ilp3¹

increased body size, with Scer\GAL4^arm.PS

Ilp3^UAS.cIa

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\IGF1

1 of 15

Yes

Hsap\IGF2

1 of 15

Yes

Hsap\INS

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Igf1

1 of 15

Yes

Mmus\Igf2

1 of 15

Yes

Mmus\Ins1

1 of 15

Yes

Rattus norvegicus (Norway rat) (3)

Rnor\Igf1

1 of 13

Yes

Rnor\Igf2

1 of 13

Yes

Rnor\Ins1

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\igf1

1 of 12

Yes

Xtro\igf2

1 of 12

Yes

Xtro\igf3

1 of 12

Yes

Xtro\ins

1 of 12

Yes

Danio rerio (Zebrafish) (7)

Drer\ins

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\ins-1

2 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190IOL )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA23862

Drosophila persimilis

Dper\GL16326

Drosophila virilis

Dvir\GJ13218

Drosophila mojavensis

Dmoj\GI12281

Drosophila grimshawi

Dgri\GH16017

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150F6Y )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17013073

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL000932

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0SG3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA000667

Bombyx mori

Silkmoth

Bmor\BGIBMGA012476

Danaus plexippus

Monarch butterfly

Dple\DPOGS206157-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012614

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_08479

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0H2F )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR012502

Ixodes scapularis

Black-legged tick

Isca\ISCW020331

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59491.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73532.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73533.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM83112.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM83113.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70794.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75680.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g06150

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g03320

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_300602

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0H56 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ilgf2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Igf1p

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000020389

Ciona intestinalis

Vase tunicate

Cint\INS-L1

Gallus gallus

Domestic chicken

Ggal\IGF1

Gallus gallus

Domestic chicken

Ggal\INS

Gallus gallus

Domestic chicken

Ggal\IGF2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (4)

Gene Symbol

Score

Source

Alignment

3 of 10

2 of 10

2 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ilp3 - ImpL2

anti tag coimmunoprecipitation, anti tag western blot

(Okamoto et al., 2013)

Ilp3 - Sdr

anti tag coimmunoprecipitation, anti tag western blot

(Okamoto et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

(UniProt, Q9VT52 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0044050

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39151

MIST (protein-protein) - An integrated Molecular Interaction Database

Ilp3

Pathways

Signaling Pathways (FlyBase)

Insulin-like Receptor Signaling Pathway Core Components -: The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Insulin signaling pathway

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-31

Cytogenetic map

67C8-67C8

Sequence location

3L:9,801,298..9,802,120 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67C8-67C8

Limits computationally determined from genome sequence between P{PZ}fry⁰²²⁴⁰ and P{lacW}l(3)L0539^L0539&P{PZ}Dhh1^rL562

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-31

(FlyBase, 2016)

3-24.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

52660

w¹¹¹⁸; P{Ilp3-GAL4.C}2/CyO

30882

w¹¹¹⁸; TI{TI}Ilp3¹

31492

y¹ v¹; P{TRiP.JF01345}attP2

33681

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00546}attP2

VDRC

v106512

P{KK111464}VIE-260B

v9199

w¹¹¹⁸; P{GD3866}v9199

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0044050

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

IP05594

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0044050

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39151

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ryu et al., 2019, Buhler et al., 2018, Hasygar and Hietakangas, 2014, Broughton et al., 2010, Veenstra et al., 2008)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: Ilp3 CG14167

(Brogiolo et al., 2001)

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39151

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF50203

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VT52

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0044050

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0044050

DRscDB

39151/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0044050

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ilp3_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0044050

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39151

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG14167

MARRVEL_MODEL

39151

modMine - A data warehouse for the modENCODE project

FBgn0044050

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VT52

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0044050

DRSC - Results frm RNAi screens

FBgn0044050

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14167-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0044050

FlyMine - An integrated database for Drosophila genomics

FBgn0044050

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39151

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Ilp3

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Insulin signaling pathway

Synonyms and Secondary IDs (28)

Reported As

Symbol Synonym

CG14167

(Rovenko et al., 2015, Fukuoh et al., 2014, Lemaitre and Miguel-Aliaga, 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Brogiolo et al., 2001)

DILP

(Nijhout, 2003, Nijhout, 2003)

DILP 3

(Das and Arur, 2017, Nässel et al., 2015)

DILP-3

(Slankster et al., 2020, Inoue et al., 2018, Nassel, 2002)

Dilp

(Rhea et al., 2007, Bradley and Leevers, 2003)

Dilp 3

(Westfall et al., 2019, Macedo et al., 2017, Claeys et al., 2002)

Dilp-3

(Hoshizaki and Gibbs, 2007)

ILP3

(Polan et al., 2020, Zhou et al., 2020, Warren et al., 2017, Barber et al., 2016)

Ilp

(Maistrenko et al., 2016, Edgar, 2006)

Ilp-3

(Pospisilik et al., 2010, Veenstra et al., 2008)

Ilp3

(Barber et al., 2021, Destalminil-Letourneau et al., 2021, Kierdorf et al., 2020, Yu et al., 2020, Brunet Avalos et al., 2019, Castillo-Quan et al., 2019, Lin et al., 2019, Mele and Johnson, 2019, Mirth et al., 2019, Croset et al., 2018, Doupé et al., 2018, Gáliková and Klepsatel, 2018, Rossi and Fernandes, 2018, Gáliková et al., 2017, Tain et al., 2017, Wang et al., 2017, Bahrampour and Thor, 2016, Cao et al., 2016, Crocker et al., 2016, Watanabe and Sakai, 2016, Wiemerslage et al., 2016, Williams et al., 2016, Alfa et al., 2015, Cagin et al., 2015, Chen et al., 2015, Lee et al., 2015, Ma et al., 2015, Williams et al., 2015, Woodcock et al., 2015, Metaxakis et al., 2014, Park et al., 2014, Lemaitre and Miguel-Aliaga, 2013, Marianes and Spradling, 2013, Sopko and Perrimon, 2013, Walker et al., 2013, Papatheodorou et al., 2012, Thomas et al., 2012, Sousa-Nunes et al., 2011, Kühnlein, 2010, Veenstra et al., 2008, FlyBase Curators et al., 2004-)

dILP-3

(Ecker et al., 2017, Teleman and Cohen, 2006)

dILP3

(Álvarez-Rendón et al., 2018, Koyama and Mirth, 2018, Staats et al., 2018, Brookheart et al., 2017, Mattila and Hietakangas, 2017, Brookheart and Duncan, 2016, Li et al., 2016, Das and Dobens, 2015, Ghosh et al., 2014, Hasygar and Hietakangas, 2014, Schriner et al., 2014, Cheetham and Brand, 2013, Garcia et al., 2013, Mirth and Shingleton, 2012, Wang et al., 2011, Teleman et al., 2008)

dILp3

(Jiang et al., 2016)

dIlp3

(Bonfini et al., 2016, Boyd et al., 2011)

dilp

(Belawat and Hafen, 2005)

dilp-3

(Wu and Brown, 2006, Hwangbo et al., 2004)

dilp3

(Atilano et al., 2021, Yang et al., 2021, Strilbytska et al., 2020, Strilbytska et al., 2020, Sudhakar et al., 2020, Wilson et al., 2020, Castillo-Quan et al., 2019, Katsube et al., 2019, Trinh et al., 2019, Zheng et al., 2019, Lin et al., 2018, Lowenstein and Velazquez-Ulloa, 2018, Semaniuk et al., 2018, Westfall et al., 2018, Andreenkova et al., 2017, Gervais and Bardin, 2017, Liao et al., 2017, Zandveld et al., 2017, Hallier et al., 2016, Kubrak et al., 2016, Kučerová et al., 2016, Liu et al., 2016, Schiesari et al., 2016, Wang et al., 2016, Hentze et al., 2015, Ismail et al., 2015, Kawasaki et al., 2015, Li and Gong, 2015, Matsuda et al., 2015, Pasco et al., 2015, Sano et al., 2015, Yan et al., 2015, Gündner et al., 2014, Ostojic et al., 2014, Piper et al., 2014, Hur et al., 2013, Kannan and Fridell, 2013, Parisi et al., 2013, Yamamoto et al., 2013, Bai et al., 2012, Marella et al., 2012, Yu et al., 2012, Alic et al., 2011, Alic et al., 2011, Guirao-Rico and Aguadé, 2011, Sheldon et al., 2011, Slack et al., 2011, Wigby et al., 2011, De Luca et al., 2010, Grönke et al., 2010, Haselton et al., 2010, Sekine et al., 2010, Slack et al., 2010, Varghese et al., 2010, Fridell et al., 2009, Hull-Thompson et al., 2009, Humphrey et al., 2009, Karpac et al., 2009, Kent et al., 2009, Okamoto et al., 2009, Zhang et al., 2009, Broughton et al., 2008, Buch et al., 2008, Clements et al., 2008, Flatt et al., 2008, Wang et al., 2008, Giannakou et al., 2007, Libert, 2007, Mattaliano et al., 2007, Broughton et al., 2005, Buch et al., 2005, Flatt et al., 2005, Melcher and Pankratz, 2005, Wu et al., 2005, Tatar et al., 2003, Ikeya and Hafen, 2002, Ikeya et al., 2002, Rulifson et al., 2002, Brogiolo et al., 2001)

dipl3

(Kakanj et al., 2016)

dlp3

(Liao et al., 2020)

ilp3

(Newell et al., 2020, Dhiman et al., 2019, Liu et al., 2018, Musashe et al., 2016, Yurgel et al., 2015, Erion and Sehgal, 2013, Song et al., 2010, Veenstra, 2009, Kim et al., 2008, Min et al., 2008, Wang et al., 2008)

Name Synonyms

Drosophila insulin-like peptide 3

(Oldham and Hafen, 2003)

Insulin-like peptide

(Maistrenko et al., 2016)

Insulin-like peptide 3

insulin-like peptide

(Flatt et al., 2005)

insulin-like peptide 3

(Rovenko et al., 2015, Amcheslavsky et al., 2014, Zhan et al., 2013, Veenstra, 2009, Brogiolo et al., 2001)

Secondary FlyBase IDs

FBgn0036047

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Project

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