A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Hsap\KCNJ2

General Information
SymbolHsap\KCNJ2SpeciesH. sapiens
Namepotassium inwardly-rectifying channel, subfamily J, member 2Annotation symbol
Feature typeengineered_foreign_geneFlyBase IDFBgn0044439
Gene Model StatusNot Applicable Stock availability 4 publicly available
Also Known AsKir2.1
Genomic Location
Chromosome (arm)Recombination map
Cytogenetic mapSequence location
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Automatically generated summary

See sections below for more information
The gene potassium inwardly-rectifying channel, subfamily J, member 2 is referred to in FlyBase by the symbol Hsap\KCNJ2 (FBgn0044439). It is a engineered_foreign_gene from Homo sapiens. Its molecular function is unknown. The biological processes in which it is involved are not known. 6 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; peripheral nervous system; multicellular structure; embryonic/larval neuron; adult segment; thoracic segment; ISN innervated muscle of A1-7; adult; hypodermal muscle of larval abdomen; portion of tissue. It has no annotated transcripts. Gene has not been localized to the genome sequence.
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Description
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FB2013_03
FB2013_02
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FlyBase Computed Cytological Location
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Experimentally Determined Cytological Location
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Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
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Annotated Transcripts
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Annotated Polypeptides
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DDBJ /
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DNA sequence
Protein sequence
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Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
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Lethality
Allele
lethal, with Scer\GAL4DAT.PL
lethal, with Scer\GAL4elav-C155
lethal, with Scer\GAL4GMR.PF
lethal, with Scer\GAL4ple.PF
lethal | larval stage, with Scer\GAL4dimm-929
lethal | larval stage, with Scer\GAL4dimm-929, Scer\GAL80Ccap.PL
partially lethal - majority die | pupal stage, with Scer\GAL4burs.PP
partially lethal - majority die | pupal stage | heat sensitive, with Scer\GAL4burs.PP, Scer\GAL80ts.αTub84B
Sterility
Allele
female sterile, with Scer\GAL4Ilp7.PY
female sterile, with Scer\GAL4Tdc2.PC
male sterile, with Scer\GAL4Crz.391
male sterile, with Scer\GAL4CrzR.3.5
male sterile, with Scer\GAL4Trh.1.0
Other Phenotypes
Allele
behavior defective, with Scer\GAL4Tdc2.PC
behavior defective | RU486 conditional, with Scer\GAL4Mef2.247.Switch
chemical resistant, with Scer\GAL4P2.4.Pdf
chemosensitive behavior defective, with Scer\GAL4Tdc2.PC
chemosensitive behavior defective | adult stage, with Scer\GAL44.64
chemosensitive behavior defective | adult stage, with Scer\GAL410.229
chemosensitive behavior defective | adult stage, with Scer\GAL417d
chemosensitive behavior defective | adult stage, with Scer\GAL4Tdc2.PC
flight defective, with Scer\GAL4Trh.PB
locomotor behavior defective | adult stage, with Scer\GAL4238Y
locomotor behavior defective | adult stage, with Scer\GAL4Tdc2.PC
locomotor behavior defective | adult stage | heat sensitive, with Scer\GAL4Ddc.HL9
locomotor behavior defective | adult stage | heat sensitive, with Scer\GAL4ple.PF
locomotor behavior defective | third instar larval stage, with Scer\GAL4dimm-929
locomotor rhythm defective, with Scer\GAL4P2.4.Pdf
locomotor rhythm defective | RU486 conditional, with Scer\GAL4Pdf.Switch1a
mating defective, with Scer\GAL4Crz.391
memory defective | adult stage | heat sensitive, with Scer\GAL4ple.PF
neuroanatomy defective, with Scer\GAL4GMR.PF
neuroanatomy defective, with Scer\GAL4αTub84B.PP
neuroanatomy defective | first instar larval stage, with Ecol\lexAOrco.T:Hsim\VP16
neuroanatomy defective | first instar larval stage, with Scer\GAL4Lim3b
neuroanatomy defective | larval stage, with Scer\GAL4Orco.PU
neuroanatomy defective | RU486 conditional, with Scer\GAL4Pdf.Switch1a
neuroanatomy defective | third instar larval stage
neuroanatomy defective | third instar larval stage, with Scer\GAL4Mhc.PW
neurophysiology defective, with Scer\GAL4eve.RRC
neurophysiology defective, with Scer\GAL4Trh.PB
neurophysiology defective, with Scer\GAL4unspecified
neurophysiology defective | larval stage, with Scer\GAL4Orco.PU
neurophysiology defective | RU486 conditional, with Scer\GAL4Pdf.Switch1a
neurophysiology defective | third instar larval stage, with Scer\GAL4Mhc.PW
paralytic | embryonic stage, with Scer\GAL4elav-C155
phototaxis defective, with Scer\GAL4cry.PZ
phototaxis defective, with Scer\GAL4tim.PE
phototaxis defective, with Scer\GAL4tim.PE, Scer\GAL80cry.PS
phototaxis defective, with Scer\GAL4tim.PE, Scer\GAL80Pdf.PS
short lived, with Scer\GAL4Lk.2.2
smell perception defective, with Scer\GAL4ey-OK107
smell perception defective, with Scer\GAL4GMR9A11
smell perception defective, with Scer\GAL4GMR10B08
smell perception defective, with Scer\GAL4GMR67B04
starvation stress response defective, with Scer\GAL4Ast.2.1
stress response defective, with Scer\GAL4Lk.2.2
taste perception defective, with Scer\GAL4E409
taste perception defective, with Scer\GAL4Lk.2.2
thermotaxis behavior defective | adult stage | heat sensitive, with Scer\GAL4DAT.PL, Scer\GAL80ts.αTub84B
thermotaxis behavior defective | adult stage | heat sensitive, with Scer\GAL4ple.PF, Scer\GAL80ts.αTub84B
visible | heat sensitive, with Scer\GAL4burs.PP, Scer\GAL80ts.αTub84B
visual behavior defective, with Scer\GAL4GMR15B07
visual behavior defective, with Scer\GAL4GMR28D01
Phenotype manifest in
Allele
A1-7 dorsal acute muscle 1, with Scer\GAL4eve.RRC
aCC neuron, with Scer\GAL4eve.RRC
Bolwig nerve, with Scer\GAL4GMR.PF
CSD interneuron, with Scer\GAL4αTub84B.PP
embryonic/larval muscle system, with Scer\GAL4Mhc.PW
embryonic/larval neuromuscular junction | first instar larval stage | heat sensitive, with Scer\GAL4Tdc2.PC, Scer\GAL80ts.αTub84B
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Tdc2.PC
embryonic/larval olfactory receptor neuron, with Scer\GAL4Orco.PU
embryonic/larval olfactory receptor neuron | first instar larval stage, with Ecol\lexAOrco.T:Hsim\VP16
embryonic/larval olfactory receptor neuron | first instar larval stage, with Scer\GAL4Lim3b
larval head, with Scer\GAL4Ccap.PP
larval LN period neuron, with Scer\GAL4GMR.PF
leg, with Scer\GAL4Ccap.PP
l-LNv neuron | RU486 conditional, with Scer\GAL4Pdf.Switch1a
LNv neuron | third instar larval stage, with Scer\GAL4unspecified
Malpighian tubule, with Scer\GAL4Lk.2.2
multidendritic neuron, with Scer\GAL4Tdc2.PC
multidendritic neuron | heat sensitive, with Scer\GAL4Tdc2.PC, Scer\GAL80ts.αTub84B
NMJ bouton, with Scer\GAL4Mhc.PW
photoreceptor cell, with Scer\GAL4ninaE.PT
proboscis, with Scer\GAL4Lk.2.2
projection neuron | larval stage, with Scer\GAL4Orco.PU
protocerebrum | RU486 conditional, with Scer\GAL4Pdf.Switch1a
type I bouton, with Scer\GAL4Tdc2.PC
type II bouton, with Scer\GAL4Tdc2.PC
type II bouton | first instar larval stage | heat sensitive, with Scer\GAL4Tdc2.PC, Scer\GAL80ts.αTub84B
ventral nerve cord | embryonic stage, with Scer\GAL4elav-C155
wing, with Scer\GAL4Ccap.PP
wing | adult stage A1, with Scer\GAL4burs.PP
wing | adult stage A1 | heat sensitive, with Scer\GAL4burs.PP, Scer\GAL80ts.αTub84B
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Allele of Hsap\KCNJ2ClassMutagenStocksKnown lesion
hide Alleles Carried on Transgenic Constructs ( 6 )
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Allele of Hsap\KCNJ2ClassMutagenStocksKnown lesion
Hsap\KCNJ2Scer\UAS.T:Avic\GFP-EGFP4 Yes
Hsap\KCNJ2AAE.Scer\UAS.T:Avic\GFP-EGFP0 Yes
Hsap\KCNJ2Ecol\lexAop.T:Avic\GFP-EGFP0 Yes
Hsap\KCNJ2R228Q.Scer\UAS.T:Avic\GFP-EGFP0 Yes
Hsap\KCNJ2Scer\FRT.Scer\UAS.T:Avic\GFP0 Yes
Hsap\KCNJ2Scer\UAS.T:Avic\GFP0 Yes
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Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
hide Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
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hide Sequence Ontology: Class of Gene
engineered_foreign_gene
 
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Interacts with
Please look at the allele data for full details of the genetic interactions
Hsap\KCNJ2 allele
Gene
References
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hide OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)
Drosophila inclusive ortholog search
No orthologs identified
Dipteran inclusive ortholog search
No orthologs identified
Insect inclusive ortholog search
No orthologs identified
Arthropod inclusive ortholog search
No orthologs identified
Metazoa inclusive ortholog search
No orthologs identified
Ortholog(s) in Drosophila melanogaster (None identified)
No D. melanogaster orthologies identified
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Gene
OMIM
HGNC
hideAAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
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hide Stocks Listed in FlyBase ( 4 )
Bloomington
6595
w*; P{UAS-Hsap\KCNJ2.EGFP}7
6596
w*; P{UAS-Hsap\KCNJ2.EGFP}1
Kyoto
108845
w*; P{UAS-Hsap\KCNJ2.EGFP}7
108846
w*; P{UAS-Hsap\KCNJ2.EGFP}1
hide Genomic Clones ( 0 )
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Additional comments
FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).
(FlyBase Curators, 1992-)
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hide Tag or Foreign Gene Data
  • Foreign sequence; species == Homo sapiens; gene == KCNJ2; HGNC:6263.
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Sequence Crossreferences
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HGNC
•
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hide Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym
Hsap\KCNJ2
 
Kir2.1
(Luan et al., 2006, Nitabach et al., 2006, Hardie et al., 2004, Hardie et al., 2002, Malpel et al., 2002, Nitabach et al., 2002, Paradis et al., 2001, Hardie et al., 2001, Joiner et al., 2006, Yang et al., 2009, Hardie et al., 2007, Fischler et al., 2007, Paradis et al., 2001, Ofstad et al., 2011, King et al., 2011, Dankert et al., 2009, Claridge-Chang et al., 2009, Wang and Anderson, 2010, Cognigni et al., 2011, Roy et al., 2007, Yuan et al., 2011, Sitaraman et al., 2012)
Kir 2.1
(Suster et al., 2003)
kir2.1
(López-Arias et al., 2011, Depetris-Chauvin et al., 2011)
Kir2.1
(Baines et al., 2001)
Name Synonym
Potassium channel, inwardly rectifying, subfamily J
 
potassium inwardly-rectifying channel, subfamily J, member 2
 
Secondary FlyBase IDs
hide References ( 45 )
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hide Recent research papers ( 15 )
Hergarden et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(10): 3967--3972
Allatostatin-A neurons inhibit feeding behavior in adult Drosophila. [FBrf0217661]
Prieto-Godino et al., 2012, PLoS Biol. 10(10): e1001400
Embryonic origin of olfactory circuitry in Drosophila: contact and activity-mediated interactions pattern connectivity in the antennal lobe. [FBrf0219665]
Sadaf et al., 2012, PLoS ONE 7(9): e46405
Synaptic Activity in Serotonergic Neurons Is Required for Air-Puff Stimulated Flight in Drosophila melanogaster. [FBrf0219558]
Schneider et al., 2012, PLoS ONE 7(12): e52007
Neuronal basis of innate olfactory attraction to ethanol in Drosophila. [FBrf0220349]
Sitaraman et al., 2012, J. Neurogenet. 26(2): 238--244
Serotonin is Critical for Rewarded Olfactory Short-Term Memory in Drosophila. [FBrf0218876]
Tayler et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(50): 20697--20702
A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila. [FBrf0220217]
Bang et al., 2011, PLoS Genet. 7(3): e1001346
Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila. [FBrf0213392]
Cognigni et al., 2011, Cell Metab. 13(1): 92--104
Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594]
Depetris-Chauvin et al., 2011, Curr. Biol. 21(21): 1783--1793
Adult-specific electrical silencing of pacemaker neurons uncouples molecular clock from circadian outputs. [FBrf0216659]
Keene et al., 2011, J. Neurosci. 31(17): 6527--6534
Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment. [FBrf0213587]
King et al., 2011, J. Neurosci. 31(3): 1139--1148
Drosophila tao Controls Mushroom Body Development and Ethanol-Stimulated Behavior through par-1. [FBrf0212818]
Koon et al., 2011, Nat. Neurosci. 14(2): 190--199
Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling. [FBrf0212895]
López-Arias et al., 2011, Peptides 32(3): 545--552
Blockade of the release of the neuropeptide leucokinin to determine its possible functions in fly behavior: Chemoreception assays. [FBrf0213007]
Ofstad et al., 2011, Nature 474(7350): 204--207
Visual place learning in Drosophila melanogaster. [FBrf0213884]
Yuan et al., 2011, Science 333(6048): 1458--1462
Light-induced structural and functional plasticity in Drosophila larval visual system. [FBrf0215276]
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