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Gene Dmel\mRpS21

General Information
Symbol	Dmel\mRpS21	Species	D. melanogaster
Name	mitochondrial ribosomal protein S21	Annotation symbol	CG32854
Feature type	protein_coding_gene	FlyBase ID	FBgn0044511
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87E8-87E8	Sequence location	3R:9,207,051..9,207,514 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial ribosomal protein S21 is referred to in FlyBase by the symbol Dmel\mRpS21 (CG32854, FBgn0044511). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: translation. 5 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein S21. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 06-12 hour embryonic stages, during early larval stages, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult salivary gland, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1631434_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mRpS21. Gene sequence location is 3R:9207051..9207514.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	References Casad et al., 2011, Genetics 189(3): 861--870 Sequence features HFA12965 BKN29137
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87E8-87E8   Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mRpS21 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mRpS21-RA FBtr0082764  NM_169518   405   87
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mRpS21-PA   FBpp0082232   10.6   87   10.65     NP_731803   AAN13563
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S21 (IPR001911) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROMERpS21
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAN13563   BI216365   BP543255   BT001577 AAN71332   CO194497   CZ480970   CZ489906
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8I0J3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0044511    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0044511 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 06-12 hour embryonic stages, during early larval stages, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0044511 expression level Developmental Stage   Expression Level embryo 00-02hr    3587 embryo 02-04hr    3201 embryo 04-06hr    3676 embryo 06-08hr    2425 embryo 08-10hr    2774 embryo 10-12hr    4761 embryo 12-14hr    3218 embryo 14-16hr    1944 embryo 16-18hr    3090 embryo 18-20hr    1904 embryo 20-22hr    2498 embryo 22-24hr    3391 larva L1    3146 larva L2    5330 larva L3 12hr old    3070 larva L3 puffstage 1-2    1772 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1805 white prepupae new    1693 white prepupae 12hr    1975 white prepupae 24hr    2103 pupae 2d postWPP    3383 pupae 3d postWPP    4874 pupae 4d postWPP    1988 adult male 01day    3038 adult male 05day    2634 adult male 30day    2025 adult female 01day    2114 adult female 05day    4265 adult female 30day    3641 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3587) embryo 02-04hr  (3201) embryo 04-06hr  (3676) embryo 06-08hr  (2425) embryo 08-10hr  (2774) embryo 10-12hr  (4761) embryo 12-14hr  (3218) embryo 14-16hr  (1944) embryo 16-18hr  (3090) embryo 18-20hr  (1904) embryo 20-22hr  (2498) embryo 22-24hr  (3391) larva L1  (3146) larva L2  (5330) larva L3 12hr old  (3070) larva L3 puffstage 1-2  (1772) larva L3 puffstage 3-6  (1482) larva L3 puffstage 7-9  (1805) white prepupae new  (1693) white prepupae 12hr  (1975) white prepupae 24hr  (2103) pupae 2d postWPP  (3383) pupae 3d postWPP  (4874) pupae 4d postWPP  (1988) adult male 01day  (3038) adult male 05day  (2634) adult male 30day  (2025) adult female 01day  (2114) adult female 05day  (4265) adult female 30day  (3641) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3587) embryo 02-04hr  (3201) embryo 04-06hr  (3676) embryo 06-08hr  (2425) embryo 08-10hr  (2774) embryo 10-12hr  (4761) embryo 12-14hr  (3218) embryo 14-16hr  (1944) embryo 16-18hr  (3090) embryo 18-20hr  (1904) embryo 20-22hr  (2498) embryo 22-24hr  (3391) larva L1  (3146) larva L2  (5330) larva L3 12hr old  (3070) larva L3 puffstage 1-2  (1772) larva L3 puffstage 3-6  1482 larva L3 puffstage 7-9  (1805) white prepupae new  (1693) white prepupae 12hr  (1975) white prepupae 24hr  (2103) pupae 2d postWPP  (3383) pupae 3d postWPP  (4874) pupae 4d postWPP  (1988) adult male 01day  (3038) adult male 05day  (2634) adult male 30day  (2025) adult female 01day  (2114) adult female 05day  (4265) adult female 30day  (3641) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3587 embryo 02-04hr    3201 embryo 04-06hr    3676 embryo 06-08hr    2425 embryo 08-10hr    2774 embryo 10-12hr    4761 embryo 12-14hr    3218 embryo 14-16hr    1944 embryo 16-18hr    3090 embryo 18-20hr    1904 embryo 20-22hr    2498 embryo 22-24hr    3391 larva L1    3146 larva L2    5330 larva L3 12hr old    3070 larva L3 puffstage 1-2    1772 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1805 white prepupae new    1693 white prepupae 12hr    1975 white prepupae 24hr    2103 pupae 2d postWPP    3383 pupae 3d postWPP    4874 pupae 4d postWPP    1988 adult male 01day    3038 adult male 05day    2634 adult male 30day    2025 adult female 01day    2114 adult female 05day    4265 adult female 30day    3641 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3587 embryo 02-04hr    3201 embryo 04-06hr    3676 embryo 06-08hr    2425 embryo 08-10hr    2774 embryo 10-12hr    4761 embryo 12-14hr    3218 embryo 14-16hr    1944 embryo 16-18hr    3090 embryo 18-20hr    1904 embryo 20-22hr    2498 embryo 22-24hr    3391 larva L1    3146 larva L2    5330 larva L3 12hr old    3070 larva L3 puffstage 1-2    1772 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1805 white prepupae new    1693 white prepupae 12hr    1975 white prepupae 24hr    2103 pupae 2d postWPP    3383 pupae 3d postWPP    4874 pupae 4d postWPP    1988 adult male 01day    3038 adult male 05day    2634 adult male 30day    2025 adult female 01day    2114 adult female 05day    4265 adult female 30day    3641 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0044511 expression level Developmental Stage   Expression Level embryo 00-02hr    3587 embryo 02-04hr    3201 embryo 04-06hr    3676 embryo 06-08hr    2425 embryo 08-10hr    2774 embryo 10-12hr    4761 embryo 12-14hr    3218 embryo 14-16hr    1944 embryo 16-18hr    3090 embryo 18-20hr    1904 embryo 20-22hr    2498 embryo 22-24hr    3391 larva L1    3146 larva L2    5330 larva L3 12hr old    3070 larva L3 puffstage 1-2    1772 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1805 white prepupae new    1693 white prepupae 12hr    1975 white prepupae 24hr    2103 pupae 2d postWPP    3383 pupae 3d postWPP    4874 pupae 4d postWPP    1988 adult male 01day    3038 adult male 05day    2634 adult male 30day    2025 adult female 01day    2114 adult female 05day    4265 adult female 30day    3641 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3587) embryo 02-04hr  (3201) embryo 04-06hr  (3676) embryo 06-08hr  (2425) embryo 08-10hr  (2774) embryo 10-12hr  (4761) embryo 12-14hr  (3218) embryo 14-16hr  (1944) embryo 16-18hr  (3090) embryo 18-20hr  (1904) embryo 20-22hr  (2498) embryo 22-24hr  (3391) larva L1  (3146) larva L2  (5330) larva L3 12hr old  (3070) larva L3 puffstage 1-2  (1772) larva L3 puffstage 3-6  (1482) larva L3 puffstage 7-9  (1805) white prepupae new  (1693) white prepupae 12hr  (1975) white prepupae 24hr  (2103) pupae 2d postWPP  (3383) pupae 3d postWPP  (4874) pupae 4d postWPP  (1988) adult male 01day  (3038) adult male 05day  (2634) adult male 30day  (2025) adult female 01day  (2114) adult female 05day  (4265) adult female 30day  (3641) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3587) embryo 02-04hr  (3201) embryo 04-06hr  (3676) embryo 06-08hr  2425 embryo 08-10hr  (2774) embryo 10-12hr  (4761) embryo 12-14hr  (3218) embryo 14-16hr  1944 embryo 16-18hr  (3090) embryo 18-20hr  1904 embryo 20-22hr  (2498) embryo 22-24hr  (3391) larva L1  (3146) larva L2  (5330) larva L3 12hr old  (3070) larva L3 puffstage 1-2  1772 larva L3 puffstage 3-6  1482 larva L3 puffstage 7-9  1805 white prepupae new  1693 white prepupae 12hr  1975 white prepupae 24hr  2103 pupae 2d postWPP  (3383) pupae 3d postWPP  (4874) pupae 4d postWPP  1988 adult male 01day  (3038) adult male 05day  (2634) adult male 30day  2025 adult female 01day  2114 adult female 05day  (4265) adult female 30day  (3641) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3587 embryo 02-04hr    3201 embryo 04-06hr    3676 embryo 06-08hr    2425 embryo 08-10hr    2774 embryo 10-12hr    4761 embryo 12-14hr    3218 embryo 14-16hr    1944 embryo 16-18hr    3090 embryo 18-20hr    1904 embryo 20-22hr    2498 embryo 22-24hr    3391 larva L1    3146 larva L2    5330 larva L3 12hr old    3070 larva L3 puffstage 1-2    1772 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1805 white prepupae new    1693 white prepupae 12hr    1975 white prepupae 24hr    2103 pupae 2d postWPP    3383 pupae 3d postWPP    4874 pupae 4d postWPP    1988 adult male 01day    3038 adult male 05day    2634 adult male 30day    2025 adult female 01day    2114 adult female 05day    4265 adult female 30day    3641 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3587 embryo 02-04hr    3201 embryo 04-06hr    3676 embryo 06-08hr    2425 embryo 08-10hr    2774 embryo 10-12hr    4761 embryo 12-14hr    3218 embryo 14-16hr    1944 embryo 16-18hr    3090 embryo 18-20hr    1904 embryo 20-22hr    2498 embryo 22-24hr    3391 larva L1    3146 larva L2    5330 larva L3 12hr old    3070 larva L3 puffstage 1-2    1772 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1805 white prepupae new    1693 white prepupae 12hr    1975 white prepupae 24hr    2103 pupae 2d postWPP    3383 pupae 3d postWPP    4874 pupae 4d postWPP    1988 adult male 01day    3038 adult male 05day    2634 adult male 30day    2025 adult female 01day    2114 adult female 05day    4265 adult female 30day    3641 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0044511    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0044511 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult salivary gland, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0044511 expression level Tissue   Expression Level Larval Central Nervous System    552 Larval Midgut    245.4 Larval Hindgut    386 Larval Malpighian Tubules    270 Larval Fat Body    238.9 Larval Salivary Gland    539.2 Larval Trachea    476.475 Larval Carcass    416.15 Adult Head    537.7 Adult Eye    534.55 Adult Brain    435.2 Adult Thoracic-Abdominal Ganglion    522.4 Adult Crop    402 Adult Midgut    410.1 Adult Hindgut    467.8 Adult Malpighian Tubules    235.2 Adult Fat Body    499.9 Adult Salivary Gland    521.8 Adult Heart    460.875 Adult VirginFemale Spermatheca    445.9 Adult InseminatedFemale Spermatheca    494 Adult Ovary    644.4 Adult Testis    335.6 Adult Male Accessory Gland    599.1 Adult Carcass    427.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (552) Larval Midgut    245.4 Larval Hindgut    386 Larval Malpighian Tubules    270 Larval Fat Body    238.9 Larval Salivary Gland  539.2 Larval Trachea    476.475 Larval Carcass    416.15 Adult Head  537.7 Adult Eye  534.55 Adult Brain    435.2 Adult Thoracic-Abdominal Ganglion  522.4 Adult Crop    402 Adult Midgut    410.1 Adult Hindgut    467.8 Adult Malpighian Tubules    235.2 Adult Fat Body    499.9 Adult Salivary Gland  521.8 Adult Heart    460.875 Adult VirginFemale Spermatheca    445.9 Adult InseminatedFemale Spermatheca    494 Adult Ovary  (644.4) Adult Testis    335.6 Adult Male Accessory Gland  (599.1) Adult Carcass    427.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    552 Larval Midgut    245.4 Larval Hindgut    386 Larval Malpighian Tubules    270 Larval Fat Body    238.9 Larval Salivary Gland    539.2 Larval Trachea    476.475 Larval Carcass    416.15 Adult Head    537.7 Adult Eye    534.55 Adult Brain    435.2 Adult Thoracic-Abdominal Ganglion    522.4 Adult Crop    402 Adult Midgut    410.1 Adult Hindgut    467.8 Adult Malpighian Tubules    235.2 Adult Fat Body    499.9 Adult Salivary Gland    521.8 Adult Heart    460.875 Adult VirginFemale Spermatheca    445.9 Adult InseminatedFemale Spermatheca    494 Adult Ovary    644.4 Adult Testis    335.6 Adult Male Accessory Gland    599.1 Adult Carcass    427.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    552 Larval Midgut    245.4 Larval Hindgut    386 Larval Malpighian Tubules    270 Larval Fat Body    238.9 Larval Salivary Gland    539.2 Larval Trachea    476.475 Larval Carcass    416.15 Adult Head    537.7 Adult Eye    534.55 Adult Brain    435.2 Adult Thoracic-Abdominal Ganglion    522.4 Adult Crop    402 Adult Midgut    410.1 Adult Hindgut    467.8 Adult Malpighian Tubules    235.2 Adult Fat Body    499.9 Adult Salivary Gland    521.8 Adult Heart    460.875 Adult VirginFemale Spermatheca    445.9 Adult InseminatedFemale Spermatheca    494 Adult Ovary    644.4 Adult Testis    335.6 Adult Male Accessory Gland    599.1 Adult Carcass    427.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0044511 expression level Tissue   Expression Level Larval Central Nervous System    552 Larval Midgut    245.4 Larval Hindgut    386 Larval Malpighian Tubules    270 Larval Fat Body    238.9 Larval Salivary Gland    539.2 Larval Trachea    476.475 Larval Carcass    416.15 Adult Head    537.7 Adult Eye    534.55 Adult Brain    435.2 Adult Thoracic-Abdominal Ganglion    522.4 Adult Crop    402 Adult Midgut    410.1 Adult Hindgut    467.8 Adult Malpighian Tubules    235.2 Adult Fat Body    499.9 Adult Salivary Gland    521.8 Adult Heart    460.875 Adult VirginFemale Spermatheca    445.9 Adult InseminatedFemale Spermatheca    494 Adult Ovary    644.4 Adult Testis    335.6 Adult Male Accessory Gland    599.1 Adult Carcass    427.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  552 Larval Midgut    245.4 Larval Hindgut    386 Larval Malpighian Tubules    270 Larval Fat Body    238.9 Larval Salivary Gland  539.2 Larval Trachea    476.475 Larval Carcass    416.15 Adult Head  537.7 Adult Eye  534.55 Adult Brain    435.2 Adult Thoracic-Abdominal Ganglion  522.4 Adult Crop    402 Adult Midgut    410.1 Adult Hindgut    467.8 Adult Malpighian Tubules    235.2 Adult Fat Body    499.9 Adult Salivary Gland  521.8 Adult Heart    460.875 Adult VirginFemale Spermatheca    445.9 Adult InseminatedFemale Spermatheca    494 Adult Ovary  644.4 Adult Testis    335.6 Adult Male Accessory Gland  599.1 Adult Carcass    427.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    552 Larval Midgut    245.4 Larval Hindgut    386 Larval Malpighian Tubules    270 Larval Fat Body    238.9 Larval Salivary Gland    539.2 Larval Trachea    476.475 Larval Carcass    416.15 Adult Head    537.7 Adult Eye    534.55 Adult Brain    435.2 Adult Thoracic-Abdominal Ganglion    522.4 Adult Crop    402 Adult Midgut    410.1 Adult Hindgut    467.8 Adult Malpighian Tubules    235.2 Adult Fat Body    499.9 Adult Salivary Gland    521.8 Adult Heart    460.875 Adult VirginFemale Spermatheca    445.9 Adult InseminatedFemale Spermatheca    494 Adult Ovary    644.4 Adult Testis    335.6 Adult Male Accessory Gland    599.1 Adult Carcass    427.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    552 Larval Midgut    245.4 Larval Hindgut    386 Larval Malpighian Tubules    270 Larval Fat Body    238.9 Larval Salivary Gland    539.2 Larval Trachea    476.475 Larval Carcass    416.15 Adult Head    537.7 Adult Eye    534.55 Adult Brain    435.2 Adult Thoracic-Abdominal Ganglion    522.4 Adult Crop    402 Adult Midgut    410.1 Adult Hindgut    467.8 Adult Malpighian Tubules    235.2 Adult Fat Body    499.9 Adult Salivary Gland    521.8 Adult Heart    460.875 Adult VirginFemale Spermatheca    445.9 Adult InseminatedFemale Spermatheca    494 Adult Ovary    644.4 Adult Testis    335.6 Adult Male Accessory Gland    599.1 Adult Carcass    427.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    537.7   NA  Eye    534.55   NA  Brain    435.2   552  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    522.4   NA  Crop    402   245.4  Midgut    410.1   386  Hindgut    467.8   270  Malpighian Tubules    235.2   238.9  Fat Body    499.9   539.2  Salivary Gland    521.8   NA  Heart    460.875   476.475  Trachea    NA   NA  VirginFemale Spermatheca    445.9   NA  InseminatedFemale Spermatheca    494   NA  Ovary    644.4   NA  Testis    335.6   NA  Male Accessory Gland    599.1   416.15  Carcass    427.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_19
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0044511 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32854-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 mRpS21GD17459 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 mRpS21GD17459 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 mRpS21GD17459
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of mRpS21 Class Mutagen Stocks Known lesion mRpS21e03199 piggyBac transposase 2 -- mRpS21e01194 1 -- mRpS21f07128 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mRpS21 Class Mutagen Stocks Known lesion mRpS21GD17459 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mRpS21KK109137 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7320 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD17459} NA P{KK109137} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}mRpS21e01194 NA PBac{RB}mRpS21e03199 NA PBac{WH}mRpS21f07128 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with UniProtKB:P82921 (Koc et al., 2001, Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with UniProtKB:P82921 (Koc et al., 2001, Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial small ribosomal subunit inferred from sequence or structural similarity with UniProtKB:P82921 (Koc et al., 2001, Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mRpS21 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0044511
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17387 Dere\GG17058 Dgri\GH18548 Dmoj\GI23247 Dper\GL23067 Dpse\GA27131 Dsec\GM25944 Dsim\GD20504 Dvir\GJ10744 Dwil\GK13350 Dyak\GE24447
Curated drosophilid orthologs	Dpse\GA17185
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001909-PA Aedes aegypti (mosquito) AGAP009152-PA Anopheles gambiae (mosquito) XP_001945754.1 Acyrthosiphon pisum (pea aphid) XP_001947877.1 Acyrthosiphon pisum (pea aphid) XP_001896422.1 Brugia malayi (roundworm nematode) BGIBMGA005841-PA Bombyx mori (silk worm) ENSBTAP00000033682 Bos taurus (bovine) CN17513 Caenorhabditis brenneri (small nematode) CBP00457 Caenorhabditis briggsae (nematode) CE09788 Caenorhabditis elegans (worm) ENSCAFP00000017367 Canis familiaris (dog) JA02905 Caenorhabditis japonica (nematode) CPIJ010957 Culex pipens (mosquito) CPIJ020036 Culex pipens (mosquito) ENSCPOP00000018458 Cavia porcellus (guinea pig) RP13068 Caenorhabditis remanei (nematode) 162875 Capitella spl (polychaete worm) 304201 Daphnia pulex (daphnia) ENSDARP00000095428 Danio rerio (zebra fish) ENSECAP00000007760 Equus caballus (horse) ENSGACP00000004307 Gymnopilus aculeatus (mushroom) ENSGALP00000000617 Gallus gallus (chicken) 86902 Hypsipyla robusta (cedar shoot borer) ENSP00000312395 Homo sapiens (human) ISCW017776-PA Ixodes scapularis (deer tick) ENSMODP00000023424 Monodelphis domestica (gray opossum) ENSMMUP00000028180 Macaca mulatta (rhesus monkey) ENSMUSP00000066990 Mus musculus (house mouse) 120285 Nematostella vectensis (starlet anemone) ENSORLP00000003309 Oryzias latipes (japanese killifish) PHUM003573-PA Pediculus humanus (human body louse) PP20346 Pristionchus pacificus (nematode) ENSPTRP00000057988 Pan troglodytes (chimpanzee) ENSRNOP00000038594 Rattus norvegicus (norway rat) XP_001177280.1 Strongylocentrotus purpuratus (purple sea urchin) 25208 Trichoplax adhaerens (metazoa) XP_966918.1 Tribolium castaneum (red flour beetle) ENSTRUP00000030379 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000058197 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14603 LH12121 ISCW017776 FBgn0241563 FBgn0215359 FBgn0198021 FBgn0191975 FBgn0180800 JGI_V11_304201 FBgn0248502 FBgn0160657 FBgn0145974 FBgn0126015 FBgn0109286 FBgn0094405 CPIJ010957 CPIJ020036 BGIBMGA005841 ACYPI007922 ACYPI007781 AGAP009152 AAEL001909 PHUM536280 GLEAN_06524
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	18131 w1118; PBac{RB}mRpS21e03199/TM6B, Tb1
Harvard	- PBac{RB}mRpS21e01194 - PBac{RB}mRpS21e03199 - PBac{WH}mRpS21f07128
VDRC	v101430 P{KK109137}VIE-260B v50338 w1118 P{GD17459}v50338 v50616 w1118; P{GD17459}v50616
Genomic Clones ( 1 )
	BACR06H18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE23482
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EC38665 FGC019E03
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0044511 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318249
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG32854 BcDNA:RE23482 (FlyBase, 1996-) Source for merge of: mRpS21 CG32854 (FlyBase, 1996-)
Additional comments	Source for merge of CG32854 BcDNA:RE23482 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	New annotation (CG32854) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169518 RefSeq (Proteins) • NP_731803 DDBJ / EMBL / GenBank • AAN13563 AAN71332 BI216365 BT001577 CZ480970 CZ489906 Entrez Gene - A searchable database of RefSeq genes. • 318249 UniProtKB/TrEMBL • Q8I0J3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S21 (IPR001911) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROMERpS21
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0044511 DRSC - Results from RNAi screens. • FBgn0044511 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0044511 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32854-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0044511 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318249 InParanoid A subset of ortholog calls from InParanoid. • AAEL001909-PA Aedes aegypti (mosquito) AGAP009152-PA Anopheles gambiae (mosquito) XP_001945754.1 Acyrthosiphon pisum (pea aphid) XP_001947877.1 Acyrthosiphon pisum (pea aphid) XP_001896422.1 Brugia malayi (roundworm nematode) BGIBMGA005841-PA Bombyx mori (silk worm) ENSBTAP00000033682 Bos taurus (bovine) CN17513 Caenorhabditis brenneri (small nematode) CBP00457 Caenorhabditis briggsae (nematode) CE09788 Caenorhabditis elegans (worm) ENSCAFP00000017367 Canis familiaris (dog) JA02905 Caenorhabditis japonica (nematode) CPIJ010957 Culex pipens (mosquito) CPIJ020036 Culex pipens (mosquito) ENSCPOP00000018458 Cavia porcellus (guinea pig) RP13068 Caenorhabditis remanei (nematode) 162875 Capitella spl (polychaete worm) 304201 Daphnia pulex (daphnia) ENSDARP00000095428 Danio rerio (zebra fish) ENSECAP00000007760 Equus caballus (horse) ENSGACP00000004307 Gymnopilus aculeatus (mushroom) ENSGALP00000000617 Gallus gallus (chicken) 86902 Hypsipyla robusta (cedar shoot borer) ENSP00000312395 Homo sapiens (human) ISCW017776-PA Ixodes scapularis (deer tick) ENSMODP00000023424 Monodelphis domestica (gray opossum) ENSMMUP00000028180 Macaca mulatta (rhesus monkey) ENSMUSP00000066990 Mus musculus (house mouse) 120285 Nematostella vectensis (starlet anemone) ENSORLP00000003309 Oryzias latipes (japanese killifish) PHUM003573-PA Pediculus humanus (human body louse) PP20346 Pristionchus pacificus (nematode) ENSPTRP00000057988 Pan troglodytes (chimpanzee) ENSRNOP00000038594 Rattus norvegicus (norway rat) XP_001177280.1 Strongylocentrotus purpuratus (purple sea urchin) 25208 Trichoplax adhaerens (metazoa) XP_966918.1 Tribolium castaneum (red flour beetle) ENSTRUP00000030379 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000058197 Xenopus tropicalis (frog) modMine - Data generated by the modENCODE project. • FBgn0044511 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14603 LH12121 ISCW017776 FBgn0241563 FBgn0215359 FBgn0198021 FBgn0191975 FBgn0180800 JGI_V11_304201 FBgn0248502 FBgn0160657 FBgn0145974 FBgn0126015 FBgn0109286 FBgn0094405 CPIJ010957 CPIJ020036 BGIBMGA005841 ACYPI007922 ACYPI007781 AGAP009152 AAEL001909 PHUM536280 GLEAN_06524
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	BcDNA:RE23482   CG32854 (Keleman et al., 2009.8.5, Marygold et al., 2007, Cammarato et al., 2011) MRP-S21 (Koc et al., 2001) MrpS21   mRpS21 (Marygold et al., 2007)
Name Synonym	mitochondrial ribosomal protein S21 (Koc et al., 2001, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0052854 FBgn0064899
References ( 18 )
Research paper	Casad et al., 2011, Genetics 189(3): 861--870 Cardiomyopathy Is Associated with Ribosomal Protein Gene Haplo-Insufficiency in Drosophila melanogaster. [FBrf0216591] Marygold et al., 2007, Genome Biol. 8(10): R216 The ribosomal protein genes and Minute loci of Drosophila melanogaster. [FBrf0205398] Koc et al., 2001, J. Biol. Chem. 276(22): 19363--19374 The small subunit of the mammalian mitochondrial ribosome: Identification of the full complement of ribosomal proteins present. [FBrf0136744]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Sardiello et al., 2005, Trends Genet. 21(1): 12--15 Energy biogenesis: one key for coordinating two genomes. [FBrf0183426]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Sardiello et al., 2003.6.11, MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. [FBrf0159903]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]