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Gene Dmel\tefu

General Information
Symbol	Dmel\tefu	Species	D. melanogaster
Name	telomere fusion	Annotation symbol	CG6535
Feature type	protein_coding_gene	FlyBase ID	FBgn0045035
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	ATM, dATM, atm/tefu
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88E3-88E4	Sequence location	3R:11,057,934..11,067,958 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene telomere fusion is referred to in FlyBase by the symbol Dmel\tefu (CG6535, FBgn0045035). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein kinase activity. There is experimental evidence that it is involved in the biological process: G2 DNA damage checkpoint; meiotic DNA double-strand break processing; telomere maintenance; photoreceptor cell maintenance; mitotic G2 DNA damage checkpoint; mitotic cell cycle checkpoint; chromosome organization; chromatin silencing at telomere; telomere capping; karyosome formation. 28 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; wing disc; chromosome, telomeric region; interommatidial bristle; macrochaeta; condensed chromosome; wing; ommatidium; rhabdomere of eye photoreceptor cell. It has one annotated transcript and one annotated polypeptide. Protein features are: ATM/Tel1; PIK-related kinase; PIK-related kinase, FATC; Phosphatidylinositol 3-/4-kinase, catalytic domain; Phosphatidylinositol 3/4-kinase, conserved site; Protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult salivary gland, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1630729_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of tefu. Gene sequence location is 3R:11057934..11067958.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88E3-88E4   Limits computationally determined from genome sequence between P{EP}CG33967EP666 and P{lacW}Hsc70-4L3929
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88B5-88C4     (Queiroz-Machado et al., 2001)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\tefu for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tefu-RB FBtr0110874  NM_001043247   8416   2767
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tefu-PB   FBpp0110174   318.0   2767   7.37     NP_001036712   ABI31168
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phosphatidylinositol 3/4-kinase, conserved site (IPR018936) Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403) PIK-related kinase, FATC (IPR003152) Protein kinase-like domain (IPR011009) PIK-related kinase (IPR014009) ATM/Tel1 (IPR015519)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 ABI31168   AY113192 AAM29197   AY395748   AY395749   AY395750 AAR89513   BF493151   BI355480   BI636463   BT029952   CZ480860   EC054607   EC055084   EC056397   EL886139   EL886140   EL886247   EL886248
UniProtKB/Swiss-Prot	Q5EAK6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References point mutation tefu[atm-5]-1 3R:11,060,956..11,060,956 comment=Nucleotide change: GT changed to AT in the splice donor, leading to retention of intron 21. Translation continues past the peptide sequence SLQQAEDFCQ into the retained intron, adding the novel MMVSWEFCDVLF sequence before reaching a premature stop codon. One of two nucleotide changes observed in mutant. The difference between the annotated and the reported site of the amino acid change is due to the authors description of a 2429 residue protein, compared to the currently annotated 2767 residue polypeptide. Position of mutation on reference sequence inferred by FlyBase curator. na_change=G11060956A (Pedersen et al., 2010) point mutation tefu[atm-5]-2 3R:11,059,008..11,059,008 na_change=G11059008A pr_change=M2495I | tefu-PB reported_pr_change=M2157I comment=One of two nucleotide changes in mutant. Probably not primarily responsible for the phenotype. The difference between the annotated and the reported site of the amino acid change is due to the authors description of a 2429 residue protein, compared to the currently annotated 2767 residue polypeptide. Position of mutation on reference sequence inferred by FlyBase curator. (Pedersen et al., 2010)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult salivary gland, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    111.675 Larval Midgut    19.8 Larval Hindgut    48.3 Larval Malpighian Tubules    31.5 Larval Fat Body    22.8 Larval Salivary Gland    132.8 Larval Trachea    61.35 Larval Carcass    31.725 Adult Head    19.6 Adult Eye    32.075 Adult Brain    31.4 Adult Thoracic-Abdominal Ganglion    37 Adult Crop    52.4 Adult Midgut    19.7 Adult Hindgut    42.1 Adult Malpighian Tubules    30.6 Adult Fat Body    29.1 Adult Salivary Gland    118.1 Adult Heart    26.4 Adult VirginFemale Spermatheca    26.5 Adult InseminatedFemale Spermatheca    30.8 Adult Ovary    89 Adult Testis    75.5 Adult Male Accessory Gland    347.6 Adult Carcass    30.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    111.675 Larval Midgut    19.8 Larval Hindgut    48.3 Larval Malpighian Tubules    31.5 Larval Fat Body    22.8 Larval Salivary Gland    132.8 Larval Trachea    61.35 Larval Carcass    31.725 Adult Head    19.6 Adult Eye    32.075 Adult Brain    31.4 Adult Thoracic-Abdominal Ganglion    37 Adult Crop    52.4 Adult Midgut    19.7 Adult Hindgut    42.1 Adult Malpighian Tubules    30.6 Adult Fat Body    29.1 Adult Salivary Gland    118.1 Adult Heart    26.4 Adult VirginFemale Spermatheca    26.5 Adult InseminatedFemale Spermatheca    30.8 Adult Ovary    89 Adult Testis    75.5 Adult Male Accessory Gland    347.6 Adult Carcass    30.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    111.675 Larval Midgut    19.8 Larval Hindgut    48.3 Larval Malpighian Tubules    31.5 Larval Fat Body    22.8 Larval Salivary Gland    132.8 Larval Trachea    61.35 Larval Carcass    31.725 Adult Head    19.6 Adult Eye    32.075 Adult Brain    31.4 Adult Thoracic-Abdominal Ganglion    37 Adult Crop    52.4 Adult Midgut    19.7 Adult Hindgut    42.1 Adult Malpighian Tubules    30.6 Adult Fat Body    29.1 Adult Salivary Gland    118.1 Adult Heart    26.4 Adult VirginFemale Spermatheca    26.5 Adult InseminatedFemale Spermatheca    30.8 Adult Ovary    89 Adult Testis    75.5 Adult Male Accessory Gland    347.6 Adult Carcass    30.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    111.675 Larval Midgut    19.8 Larval Hindgut    48.3 Larval Malpighian Tubules    31.5 Larval Fat Body    22.8 Larval Salivary Gland    132.8 Larval Trachea    61.35 Larval Carcass    31.725 Adult Head    19.6 Adult Eye    32.075 Adult Brain    31.4 Adult Thoracic-Abdominal Ganglion    37 Adult Crop    52.4 Adult Midgut    19.7 Adult Hindgut    42.1 Adult Malpighian Tubules    30.6 Adult Fat Body    29.1 Adult Salivary Gland    118.1 Adult Heart    26.4 Adult VirginFemale Spermatheca    26.5 Adult InseminatedFemale Spermatheca    30.8 Adult Ovary    89 Adult Testis    75.5 Adult Male Accessory Gland    347.6 Adult Carcass    30.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    111.675 Larval Midgut    19.8 Larval Hindgut    48.3 Larval Malpighian Tubules    31.5 Larval Fat Body    22.8 Larval Salivary Gland    132.8 Larval Trachea    61.35 Larval Carcass    31.725 Adult Head    19.6 Adult Eye    32.075 Adult Brain    31.4 Adult Thoracic-Abdominal Ganglion    37 Adult Crop    52.4 Adult Midgut    19.7 Adult Hindgut    42.1 Adult Malpighian Tubules    30.6 Adult Fat Body    29.1 Adult Salivary Gland    118.1 Adult Heart    26.4 Adult VirginFemale Spermatheca    26.5 Adult InseminatedFemale Spermatheca    30.8 Adult Ovary    89 Adult Testis    75.5 Adult Male Accessory Gland    347.6 Adult Carcass    30.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    111.675 Larval Midgut    19.8 Larval Hindgut    48.3 Larval Malpighian Tubules    31.5 Larval Fat Body    22.8 Larval Salivary Gland    132.8 Larval Trachea    61.35 Larval Carcass    31.725 Adult Head    19.6 Adult Eye    32.075 Adult Brain    31.4 Adult Thoracic-Abdominal Ganglion    37 Adult Crop    52.4 Adult Midgut    19.7 Adult Hindgut    42.1 Adult Malpighian Tubules    30.6 Adult Fat Body    29.1 Adult Salivary Gland    118.1 Adult Heart    26.4 Adult VirginFemale Spermatheca    26.5 Adult InseminatedFemale Spermatheca    30.8 Adult Ovary    89 Adult Testis    75.5 Adult Male Accessory Gland    347.6 Adult Carcass    30.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    111.675 Larval Midgut    19.8 Larval Hindgut    48.3 Larval Malpighian Tubules    31.5 Larval Fat Body    22.8 Larval Salivary Gland    132.8 Larval Trachea    61.35 Larval Carcass    31.725 Adult Head    19.6 Adult Eye    32.075 Adult Brain    31.4 Adult Thoracic-Abdominal Ganglion    37 Adult Crop    52.4 Adult Midgut    19.7 Adult Hindgut    42.1 Adult Malpighian Tubules    30.6 Adult Fat Body    29.1 Adult Salivary Gland    118.1 Adult Heart    26.4 Adult VirginFemale Spermatheca    26.5 Adult InseminatedFemale Spermatheca    30.8 Adult Ovary    89 Adult Testis    75.5 Adult Male Accessory Gland    347.6 Adult Carcass    30.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    111.675 Larval Midgut    19.8 Larval Hindgut    48.3 Larval Malpighian Tubules    31.5 Larval Fat Body    22.8 Larval Salivary Gland    132.8 Larval Trachea    61.35 Larval Carcass    31.725 Adult Head    19.6 Adult Eye    32.075 Adult Brain    31.4 Adult Thoracic-Abdominal Ganglion    37 Adult Crop    52.4 Adult Midgut    19.7 Adult Hindgut    42.1 Adult Malpighian Tubules    30.6 Adult Fat Body    29.1 Adult Salivary Gland    118.1 Adult Heart    26.4 Adult VirginFemale Spermatheca    26.5 Adult InseminatedFemale Spermatheca    30.8 Adult Ovary    89 Adult Testis    75.5 Adult Male Accessory Gland    347.6 Adult Carcass    30.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    19.6   NA  Eye    32.075   NA  Brain    31.4   111.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    37   NA  Crop    52.4   19.8  Midgut    no informative data   48.3  Hindgut    42.1   31.5  Malpighian Tubules    30.6   no informative data  Fat Body    29.1   132.8  Salivary Gland    118.1   NA  Heart    26.4   61.35  Trachea    NA   NA  VirginFemale Spermatheca    26.5   NA  InseminatedFemale Spermatheca    30.8   NA  Ovary    89   NA  Testis    75.5   NA  Male Accessory Gland    347.6   31.725  Carcass    30.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    8 ovary, mated 4-day female    5 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    8 ovary, mated 4-day female    5 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    8 ovary, mated 4-day female    5 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    8 ovary, mated 4-day female    5 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    8 ovary, mated 4-day female    5 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    8 ovary, mated 4-day female    5 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    8 ovary, mated 4-day female    5 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    8 ovary, mated 4-day female    5 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    5 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    5 adult male 30day    4 adult female 01day    3 adult female 05day    8 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    5 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    5 adult male 30day    4 adult female 01day    3 adult female 05day    8 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    5 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    5 adult male 30day    4 adult female 01day    3 adult female 05day    8 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    5 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    5 adult male 30day    4 adult female 01day    3 adult female 05day    8 adult female 30day    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    5 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    5 adult male 30day    4 adult female 01day    3 adult female 05day    8 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    5 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    5 adult male 30day    4 adult female 01day    3 adult female 05day    8 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    5 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    5 adult male 30day    4 adult female 01day    3 adult female 05day    8 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    5 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    5 adult male 30day    4 adult female 01day    3 adult female 05day    8 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    3 embryonic 1182-4H    7 embryonic GM2    17 embryonic Kc167    12 embryonic S1    9 embryonic S3    16 leg disc CME L1    4 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    8 ovary fGS/OSS    5 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    3 embryonic 1182-4H    7 embryonic GM2    17 embryonic Kc167    12 embryonic S1    9 embryonic S3    16 leg disc CME L1    4 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    8 ovary fGS/OSS    5 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    3 embryonic 1182-4H    7 embryonic GM2    17 embryonic Kc167    12 embryonic S1    9 embryonic S3    16 leg disc CME L1    4 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    8 ovary fGS/OSS    5 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    3 embryonic 1182-4H    7 embryonic GM2    17 embryonic Kc167    12 embryonic S1    9 embryonic S3    16 leg disc CME L1    4 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    8 ovary fGS/OSS    5 ovary OSC    5 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    3 embryonic 1182-4H    7 embryonic GM2    17 embryonic Kc167    12 embryonic S1    9 embryonic S3    16 leg disc CME L1    4 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    8 ovary fGS/OSS    5 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    3 embryonic 1182-4H    7 embryonic GM2    17 embryonic Kc167    12 embryonic S1    9 embryonic S3    16 leg disc CME L1    4 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    8 ovary fGS/OSS    5 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    3 embryonic 1182-4H    7 embryonic GM2    17 embryonic Kc167    12 embryonic S1    9 embryonic S3    16 leg disc CME L1    4 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    8 ovary fGS/OSS    5 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    3 embryonic 1182-4H    7 embryonic GM2    17 embryonic Kc167    12 embryonic S1    9 embryonic S3    16 leg disc CME L1    4 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    8 ovary fGS/OSS    5 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045035 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6535-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | heat sensitive (with Df(3R)PG4) tefuatm-8 lethal | pupal stage tefuunspecified lethal | pupal stage | recessive tefuatm-1 tefuatm-2 tefuatm-3 tefuatm-4 tefuatm-5 tefuatm-6 tefuatm-7 tefustg tefuwk tefuΔ11 tefuΔ356 lethal | recessive tefu1 lethal | recessive | heat sensitive tefuatm-8 viable tefured31 viable, with Scer\GAL4pnr-MD237 tefuGD11950 Sterility Allele female sterile | recessive tefuΔ11 tefuΔ356 Other Phenotypes Allele decreased cell death | third instar larval stage, with Scer\GAL4elav.PU tefudsRNA.Scer\UAS increased cell death tefuΔ356 increased cell death | heat sensitive tefuatm-8 increased cell death | third instar larval stage, with Scer\GAL4elav.PU tefudsRNA.Scer\UAS increased cell number | third instar larval stage, with Scer\GAL4elav.PU tefudsRNA.Scer\UAS increased cell number | third instar larval stage, with Scer\GAL4GMR.PU tefudsRNA.Scer\UAS locomotor behavior defective | female | heat sensitive (with Df(3R)PG4) tefuatm-8 locomotor behavior defective | male | heat sensitive (with Df(3R)PG4) tefuatm-8 mitotic cell cycle defective tefu1 tefustg tefuwk tefuΔ356 mitotic cell cycle defective (with tefu1) tefuΔ356 mitotic cell cycle defective (with tefuatm-3) tefuatm-6 mitotic cell cycle defective (with tefuatm-6) tefuatm-3 mitotic cell cycle defective (with tefuΔ356) tefu1 neuroanatomy defective, with Scer\GAL4elav.PU tefudsRNA.Scer\UAS neuroanatomy defective, with Scer\GAL4GMR.PU tefudsRNA.Scer\UAS neuroanatomy defective | temperature conditional, with Scer\GAL4hs.PB tefudsRNA.Scer\UAS radiation sensitive tefuatm-6 tefustg tefuwk radiation sensitive (with Df(3R)PG4) tefuatm-8 visible | recessive | heat sensitive tefuatm-8 Phenotype manifest in Allele adult thorax & chaeta | conditional ts (with Df(3R)PG4) tefuatm-8 anaphase & condensed nuclear chromosome tefuunspecified anaphase & condensed nuclear chromosome (with tefuatm-3) tefuatm-6 anaphase & condensed nuclear chromosome (with tefuatm-6) tefuatm-3 antenna | P-stage tefuatm-1 tefuatm-2 tefuatm-3 tefuatm-4 tefuatm-5 tefuatm-6 tefuatm-7 chaeta | P-stage tefuatm-1 tefuatm-2 tefuatm-3 tefuatm-4 tefuatm-5 tefuatm-6 tefuatm-7 chorion | germline clone | maternal effect tefuatm-6 chromosome, telomeric region tefuΔ356 tefuatm-6 tefustg tefuwk chromosome, telomeric region (with tefuatm-3) tefuatm-6 chromosome, telomeric region (with tefuatm-6) tefuatm-3 chromosome & neuroblast | third instar larval stage 2 tefuunspecified cleavage nucleus | germline clone | maternal effect tefuatm-6 condensed chromosome tefuatm-6 dorsal appendage | germline clone | maternal effect tefuatm-6 eye tefuΔ356 tefured31 tefuunspecified eye, with Scer\GAL4GMR.PU tefudsRNA.Scer\UAS eye (with Df(3R)PG4) tefuΔ356 eye (with tefu1) tefuΔ356 eye (with tefuΔ356) tefu1 eye | heat sensitive tefuatm-8 eye | heat sensitive (with Df(3R)PG4) tefuatm-8 eye | P-stage tefuatm-1 tefuatm-2 tefuatm-3 tefuatm-4 tefuatm-5 tefuatm-6 tefuatm-7 eye-antennal disc | heat sensitive tefuatm-8 eye disc tefuΔ356 eye disc | anterior | heat sensitive tefuatm-8 eye disc posterior to the morphogenetic furrow | third instar larval stage, with Scer\GAL4elav.PU tefudsRNA.Scer\UAS eye disc posterior to the morphogenetic furrow | third instar larval stage, with Scer\GAL4GMR.PU tefudsRNA.Scer\UAS eye photoreceptor cell | temperature conditional, with Scer\GAL4hs.PB tefudsRNA.Scer\UAS eye photoreceptor cell | third instar larval stage, with Scer\GAL4elav.PU tefudsRNA.Scer\UAS eye photoreceptor cell | third instar larval stage, with Scer\GAL4GMR.PU tefudsRNA.Scer\UAS interommatidial bristle tefuunspecified karyosome | heat sensitive tefuatm-8 leg | P-stage tefuatm-1 tefuatm-2 tefuatm-3 tefuatm-4 tefuatm-5 tefuatm-6 tefuatm-7 macrochaeta tefuΔ356 macrochaeta (with Df(3R)PG4) tefuΔ356 macrochaeta (with tefu1) tefuΔ356 macrochaeta (with tefuΔ356) tefu1 metaphase & condensed nuclear chromosome (with tefuatm-3) tefuatm-6 metaphase & condensed nuclear chromosome (with tefuatm-6) tefuatm-3 mitosis & nuclear chromosome tefuΔ356 tefu1 tefustg tefuwk mitosis & nuclear chromosome | maternal effect | germ-line clone tefuatm-6 ommatidium tefuunspecified rhabdomere of eye photoreceptor cell, with Scer\GAL4elav.PU tefudsRNA.Scer\UAS rhabdomere of eye photoreceptor cell, with Scer\GAL4GMR.PU tefudsRNA.Scer\UAS spindle | germline clone | maternal effect tefuatm-6 wing tefuΔ356 tefured31 wing (with Df(3R)PG4) tefuΔ356 wing (with tefu1) tefuΔ356 wing (with tefuΔ356) tefu1 wing | heat sensitive tefuatm-8 wing | heat sensitive (with Df(3R)PG4) tefuatm-8 wing | P-stage tefuatm-1 tefuatm-2 tefuatm-3 tefuatm-4 tefuatm-5 tefuatm-6 tefuatm-7 wing disc tefuΔ356
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of tefu Class Mutagen Stocks Known lesion tefuatm-3 ethyl methanesulfonate 1 -- tefuatm-6 loss of function allele ethyl methanesulfonate 1 Yes tefuatm-8 heat sensitive loss of function allele ethyl methanesulfonate 1 -- tefue00198 1 -- tefue03093 piggyBac transposase 1 -- tefuGS13617 1 Yes tefuMB09945 1 -- tefu1 hypomorphic allele - genetic evidence 0 Yes tefuatm-1 ethyl methanesulfonate 0 -- tefuatm-2 ethyl methanesulfonate 0 -- tefuatm-4 ethyl methanesulfonate 0 -- tefuatm-5 ethyl methanesulfonate 0 -- tefuatm-7 ethyl methanesulfonate 0 -- tefured31 0 Yes tefustg recombination SCEI endonuclease FLPase ends-in gene targeting gene targeting by homologous recombination 0 Yes tefuunspecified 0 -- tefuwk recombination SCEI endonuclease FLPase ends-in gene targeting gene targeting by homologous recombination 0 Yes tefuZIII-5190 0 -- tefuΔ11 hypomorphic allele - genetic evidence 0 Yes tefuΔ356 loss of function allele, hypomorphic allele - genetic evidence 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tefu Class Mutagen Stocks Known lesion tefuGD11950 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tefuJF01422 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tefuKK100008 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tefu+t14.5 in vitro construct - genomic fragment 0 Yes tefudsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes tefuNIG.6535R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes tefuScer\SceI.RS.cGa in vitro construct 0 Yes tefuScer\UAS.cOa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC471 (Christensen et al., 2008.4.15) Df(3R)BSC750 (Christensen et al., 2009.2.28) Df(3R)Exel7323 (Ryder, 2004.4.26) Df(3R)Hsc70-4Δ11 (Bronk et al., 2001) Df(3R)Hsc70-4Δ356 (Bronk et al., 2001, Bi et al., 2004) Df(3R)PG4 (Silva et al., 2004) Df(3R)red3l (Queiroz-Machado et al., 2001)
Not disrupted in	Df(3R)293γ5 (Queiroz-Machado et al., 2001) Df(3R)red-P52 (Queiroz-Machado et al., 2001) Df(3R)su(Hw)7 (Queiroz-Machado et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11950} NA P{KK100008} NA P{NIG.6535R} NA P{TRiP.JF01422} NA P{UAS-atm.O} NA characterization construct P{FRT(tefu.Scer\SceI.RS.cGa)} NA P{tefu+t14.5} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}tefue00198 NA PBac{RB}tefue03093 NA insertion of mobile activating element P{GSV1}EP-J76EP-J76 NA P{GSV6}tefuGS13617 NA insertion of enhancer trap binary system Mi{ET1}tefuMB09945 No
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chromatin silencing at telomere inferred from mutant phenotype (Oikemus et al., 2004) chromosome organization inferred from mutant phenotype (Silva et al., 2004, Bi et al., 2004, Song et al., 2004, Ciapponi et al., 2006) G2 DNA damage checkpoint inferred from mutant phenotype (Bi et al., 2005) karyosome formation inferred from direct assay (Joyce et al., 2011) meiotic DNA double-strand break processing inferred from direct assay (Joyce et al., 2011) mitotic cell cycle checkpoint inferred from genetic interaction with stg (Rimkus et al., 2008) mitotic G2 DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) photoreceptor cell maintenance inferred from mutant phenotype (Rimkus et al., 2008) telomere capping inferred from mutant phenotype (Ciapponi et al., 2006) telomere maintenance inferred from mutant phenotype (Bi et al., 2004, Bi et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
protein kinase activity inferred from sequence or structural similarity (Sekelsky et al., 2000) non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR015519 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell cycle checkpoint inferred from sequence or structural similarity (Sekelsky et al., 2000) histone phosphorylation inferred from electronic annotation with InterPro:IPR015519 (FlyBase Curators et al., 2004-) phosphorylation non-traceable author statement (Morrison et al., 2000) replicative senescence inferred from electronic annotation with InterPro:IPR015519 (FlyBase Curators et al., 2004-) response to ionizing radiation inferred from electronic annotation with InterPro:IPR015519 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tefu allele Gene References tefustg mre11 (Bi et al., 2004) tefuwk Lig4 (Bi et al., 2004) tefuΔ356 p53 (Oikemus et al., 2004, Song et al., 2004) unspecified mei-41 (Ciapponi et al., 2006) nbs (Ciapponi et al., 2006) pbl (Gregory et al., 2007) rad50 (Ciapponi et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0045035 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41839 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q5EAK6
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6DV65H Dipteran inclusive ortholog search EOG6Z62WH Insect inclusive ortholog search EOG62JMMH Arthropod inclusive ortholog search EOG600009 Metazoa inclusive ortholog search EOG6RJTTJ
Orthologs in Drosophila Species (EOG6DV65H)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\tefu     Drosophila simulans   Dsim\GD20371 Y   Drosophila sechellia   Dsec\GM25794 Y   Drosophila erecta   Dere\GG20781 Y   Drosophila yakuba   Dyak\GE26399 Y   Drosophila ananassae   Dana\GF11791 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19668 Y   Drosophila persimilis   Dper\GL12075     Drosophila willistoni   Dwil\GK12780 Y   Drosophila virilis   Dvir\GJ14811 Y   Drosophila mojavensis   Dmoj\GI11054 Y   Drosophila grimshawi   Dgri\GH22366 Y
Orthologs in non-Drosophila Dipterans (EOG6Z62WH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014900   Anopheles gambiae Malaria mosquito  Agam\AGAP009632   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001777   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001772
Orthologs in non-Dipteran Insects (EOG62JMMH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50923   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020124   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19300   Atta cephalotes Leafcutter ant  Acep\ACEP15112   Atta cephalotes Leafcutter ant  Acep\ACEP15109   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20245   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20246   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23556   Linepithema humile Argentine ant  Lhum\LH26244   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27268   Solenopsis invicta Red fire ant  Sinv\SINV24693   Solenopsis invicta Red fire ant  Sinv\SINV24705   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007853   Pediculus humanus Human body louse  Phum\PHUM472530   Tribolium castaneum Red flour beetle  Tcas\TC008566
Orthologs in non-Insect Arthropods (EOG600009)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_311533   Ixodes scapularis Deer tick  Isca\ISCW016588   Ixodes scapularis Deer tick  Isca\ISCW016587
Orthologs in non-Arthropod Metazoa (EOG6RJTTJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\atm-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021593gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011072gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025176gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005652gn   Danio rerio Zebrafish  Drer\atm   Danio rerio Zebrafish  Drer\atm   Xenopus tropicalis Western clawed frog  Xtro\atm   Gallus gallus Domestic chicken  Ggal\ATM   Mus musculus House mouse  Mmus\Atm   Rattus norvegicus Norway rat  Rnor\Atm   Homo sapiens Human  Hsap\ATM
Human Orthologs (1)
Gene OMIM HGNC Hsap\ATM
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20371 Drosophila sechellia Dsec\GM25794 Drosophila erecta Dere\GG20781 Drosophila yakuba Dyak\GE26399 Drosophila ananassae Dana\GF11791 Drosophila pseudoobscura pseudoobscura Dpse\GA19668 Drosophila willistoni Dwil\GK12780 Drosophila virilis Dvir\GJ14811 Drosophila mojavensis Dmoj\GI11054 Drosophila grimshawi Dgri\GH22366
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	31635 y1 v1; P{TRiP.JF01422}attP2 8624 P{neoFRT}82B tefuatm-8 e1/TM3, Sb1 29888 w1118; Mi{ET1}tefuMB09945/TM6C, Sb1 8625 w*; P{neoFRT}82B tefuatm-3 e1/TM6B, Tb1 8626 w*; P{neoFRT}82B tefuatm-6 e1/TM6B, Tb1
Harvard	- PBac{RB}tefue00198 - PBac{RB}tefue03093
Kyoto	204829 y1 w67c23; P{GSV6}tefuGS13617/TM3, Sb1 Ser1
VDRC	v108074 P{KK100008}VIE-260B v22502 w1118; P{GD11950}v22502/TM3
Genomic Clones ( 2 )
	BACR13A02 BACR32A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT01448
Other clones	IP17328
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM31003 SD18147
Other clones	EC054607 EC055084 EC056397 IP17428 IP17528
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0045035 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41839
Antibody Information
	polyclonal (Chiolo et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: atm CG6535 (FlyBase, 1996-) Source for identity of: tefu atm (Oikemus et al., 2004)
Source for database merge of	Source for merge of: tefu atm (Oikemus, 2004.2.25)
Additional comments	Source for identity of atm CG6535 was sequence comparison (date:040205). (FlyBase, 1996-)
Other Comments
	tefu is required for double strand break repair in the oocyte. (Joyce et al., 2011) tefu is not essential for cell cycle arrest at high doses of X-irradiation. (Oikemus et al., 2006) tefu mutants show a high level of spontaneous telomere fusions in larval neuroblasts. (Bi et al., 2004) tefu is required for the maintenance of normal telomeres. (Silva et al., 2004, Bi et al., 2004, Song et al., 2004) tefu mutants show a high level of spontaneous telomere fusions and other chromosome abnormalities in larval neuroblasts. (Silva et al., 2004) tefu mutants show a high level of spontaneous telomere fusions in larval neuroblasts. Mutants show an increase in spontaneous p53-dependent apoptosis. (Song et al., 2004) S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on proteolysis of dup and geminin genes. (Higa et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) tefu is essential for normal cell proliferation, the gene may have a role in protecting the linear ends of chromosomes. (Queiroz-Machado et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001043247 RefSeq (Proteins) • NP_001036712 DDBJ / EMBL / GenBank • AAM29197 AAR89513 ABI31168 AY113192 AY395748 AY395749 AY395750 BF493151 CZ480860 Entrez Gene - A searchable database of RefSeq genes. • 41839 UniProtKB/Swiss-Prot • Q5EAK6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phosphatidylinositol 3/4-kinase, conserved site (IPR018936) Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403) PIK-related kinase, FATC (IPR003152) Protein kinase-like domain (IPR011009) PIK-related kinase (IPR014009) ATM/Tel1 (IPR015519)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0045035 DRSC - Results from RNAi screens. • FBgn0045035 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045035 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6535-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0045035 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41839 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/atm-tefu1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41839 modMine - Data generated by the modENCODE project. • FBgn0045035 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q5EAK6
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	ATM (Higa et al., 2003, Purdy and Su, 2004, Silva et al., 2003, Morrison et al., 2000, Morrison et al., 2000, Gregory et al., 2007, Cenci et al., 2005, Garcia et al., 2007, Cenci et al., 2008, Brodsky et al., 2004, Katzenberger et al., 2006, Rimkus et al., 2008, Mehrotra et al., 2008, Rehwinkel et al., 2005, Lu et al., 2010, Kondo and Perrimon, 2011) atm (Bi et al., 2004, Silva et al., 2004, Bi et al., 2005, Oikemus et al., 2004, Oikemus et al., 2004, Oikemus et al., 2006, Cenci et al., 2006, Raffa et al., 2005, Klattenhoff et al., 2007, Wells et al., 2006, Baehrecke, 2006, Oikemus et al., 2006, Klovstad et al., 2008, Doheny et al., 2008, Castellanos et al., 2008, Rong, 2008, Komonyi et al., 2009, Rong, 2008, Joyce et al., 2011, Gao et al., 2010, Morciano et al., 2009) Atm (Raffa et al., 2011) atm/tefu (Oikemus et al., 2007, Oikemus et al., 2006) CG6535 (Song et al., 2004, Campbell et al., 2004, Laurencon et al., 2003, Zhang et al., 2000, Sekelsky et al., 2000, Bronk et al., 2001, Molnar et al., 2006, Brodsky et al., 2004, Keleman et al., 2009.8.5, Rehwinkel et al., 2005, Ni et al., 2008, Gong et al., 2005) dATM (Song et al., 2004, Yamasaki et al., 2007, Pedersen et al., 2010) tef (Queiroz-Machado et al., 2001) tefu (Turner et al., 2008, Gregory et al., 2007, Ciapponi et al., 2006, Bi et al., 2005, Cenci et al., 2008, Christensen et al., 2008.4.15, Molnar et al., 2006, Oikemus et al., 2006, Singer and Gall, 2011, Southall and Brand, 2009, Lee et al., 2012, Mehrotra et al., 2008, Christensen et al., 2009.2.28, Rickmyre et al., 2007, Frydrychova et al., 2008, Anderson et al., 2009, Komonyi et al., 2009, Musarò et al., 2008, Joyce et al., 2011, Morciano et al., 2009, Chen et al., 2006, Gong et al., 2005, Reis et al., 2011, Pedersen et al., 2010, Japanese National Institute of Genetics, 2012.5.21) Tefu (Hochwagen, 2006) unnamed (Hing et al., 1999)
Name Synonym	ataxia telangiectasia mutated (Baehrecke, 2006, Doheny et al., 2008) ataxia-telangiectasia mutated (Katzenberger et al., 2006) ataxia telengiesctasia mutated (Castellanos et al., 2008) Drosophila ATM (Brodsky et al., 2004) telomere fusion (Pedersen et al., 2008, Queiroz-Machado et al., 2001, Rickmyre et al., 2007, Rickmyre et al., 2007, Musarò et al., 2008, Oikemus et al., 2006, Morciano et al., 2009)
Secondary FlyBase IDs
	FBgn0038308
References ( 96 )
Generate a list of	All references relating to this gene ( 96 )
List References by type	Research paper  ( 59 ) Supplementary material  ( 6 ) Review  ( 5 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 8 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 12 )
	Beaucher et al., 2012, Genetics 191(2): 407--417 Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline. [FBrf0218640] Lee et al., 2012, DNA Repair 11(9): 741--752 Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks. [FBrf0219169] Mitchell and Friesen, 2012, J. Virol. 86(24): 13542--13553 Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication. [FBrf0220004] Petersen et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(11): E656--E664 ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila. [FBrf0217740] Shaukat et al., 2012, PLoS ONE 7(10): e47447 A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect. [FBrf0219770] Chiolo et al., 2011, Cell 144(5): 732--744 Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair. [FBrf0213146] Joyce et al., 2011, J. Cell Biol. 195(3): 359--367 Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. [FBrf0216489] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Moskalev et al., 2011, Biogerontology 12(3): 253--263 Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. [FBrf0213740] Raffa et al., 2011, Nucleus 2(5): 383--391 Terminin: A protein complex that mediates epigenetic maintenance of Drosophila telomeres. [FBrf0216520] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Singer and Gall, 2011, Nucleus 2(5): 403--409 An inducible nuclear body in the Drosophila germinal vesicle. [FBrf0216533] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...