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Gene Dmel\Gr64a

General Information
Symbol	Dmel\Gr64a	Species	D. melanogaster
Name	Gustatory receptor 64a	Annotation symbol	CG32261
Feature type	protein_coding_gene	FlyBase ID	FBgn0045479
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64A4-64A4	Sequence location	3L:4,026,769..4,028,600 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Gustatory receptor 64a is referred to in FlyBase by the symbol Dmel\Gr64a (CG32261, FBgn0045479). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sweet taste receptor activity. There is experimental evidence that it is involved in the biological process: detection of maltose stimulus; detection of chemical stimulus involved in sensory perception of taste; detection of sucrose stimulus; proboscis extension reflex; sensory perception of sweet taste; detection of glucose. 7 alleles are reported. The phenotype of these alleles is annotated with: large labellar taste bristle. It has one annotated transcript and one annotated polypeptide. Protein features are: Gustatory receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of no expression detected. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1638399_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Gr64a. Gene sequence location is 3L:4026769..4028600.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64A4-64A4   Limits computationally determined from genome sequence between P{PZ}Sc205634 and P{PZ}l(3)rG166rG166
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gr64a for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.46 May be expressed as a polycistronic mRNA encoding as many as 6 genes of the GR64a-f cluster (FBrf0206328).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gr64a-RA FBtr0073194  NM_168048   1488   456
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gr64a-PA   FBpp0073050   52.8   456   9.83     NP_728920   AAN11576
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Gustatory receptor (IPR009318)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAN11576   EY198697   FE527537
UniProtKB/Swiss-Prot	P83293
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
RT-PCR Stage Tissue/Position (including subcellular localization) Reference adult stage   proboscis   (Wisotsky et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    5.6 Larval Hindgut    2.7 Larval Malpighian Tubules    3.6 Larval Fat Body    7.6 Larval Salivary Gland    3.3 Larval Trachea    0.825 Larval Carcass    2.475 Adult Head    1.8 Adult Eye    1.275 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    4 Adult Midgut    8.8 Adult Hindgut    6 Adult Malpighian Tubules    2.8 Adult Fat Body    4.2 Adult Salivary Gland    1.8 Adult Heart    0.875 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    2 Adult Testis    11.3 Adult Male Accessory Gland    2.3 Adult Carcass    3.7 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    5.6 Larval Hindgut    2.7 Larval Malpighian Tubules    3.6 Larval Fat Body    7.6 Larval Salivary Gland    3.3 Larval Trachea    0.825 Larval Carcass    2.475 Adult Head    1.8 Adult Eye    1.275 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    4 Adult Midgut    8.8 Adult Hindgut    6 Adult Malpighian Tubules    2.8 Adult Fat Body    4.2 Adult Salivary Gland    1.8 Adult Heart    0.875 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    2 Adult Testis    11.3 Adult Male Accessory Gland    2.3 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    5.6 Larval Hindgut    2.7 Larval Malpighian Tubules    3.6 Larval Fat Body    7.6 Larval Salivary Gland    3.3 Larval Trachea    0.825 Larval Carcass    2.475 Adult Head    1.8 Adult Eye    1.275 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    4 Adult Midgut    8.8 Adult Hindgut    6 Adult Malpighian Tubules    2.8 Adult Fat Body    4.2 Adult Salivary Gland    1.8 Adult Heart    0.875 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    2 Adult Testis    11.3 Adult Male Accessory Gland    2.3 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    5.6 Larval Hindgut    2.7 Larval Malpighian Tubules    3.6 Larval Fat Body    7.6 Larval Salivary Gland    3.3 Larval Trachea    0.825 Larval Carcass    2.475 Adult Head    1.8 Adult Eye    1.275 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    4 Adult Midgut    8.8 Adult Hindgut    6 Adult Malpighian Tubules    2.8 Adult Fat Body    4.2 Adult Salivary Gland    1.8 Adult Heart    0.875 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    2 Adult Testis    11.3 Adult Male Accessory Gland    2.3 Adult Carcass    3.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    5.6 Larval Hindgut    2.7 Larval Malpighian Tubules    3.6 Larval Fat Body    7.6 Larval Salivary Gland    3.3 Larval Trachea    0.825 Larval Carcass    2.475 Adult Head    1.8 Adult Eye    1.275 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    4 Adult Midgut    8.8 Adult Hindgut    6 Adult Malpighian Tubules    2.8 Adult Fat Body    4.2 Adult Salivary Gland    1.8 Adult Heart    0.875 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    2 Adult Testis    11.3 Adult Male Accessory Gland    2.3 Adult Carcass    3.7 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    5.6 Larval Hindgut    2.7 Larval Malpighian Tubules    3.6 Larval Fat Body    7.6 Larval Salivary Gland    3.3 Larval Trachea    0.825 Larval Carcass    2.475 Adult Head    1.8 Adult Eye    1.275 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    4 Adult Midgut    8.8 Adult Hindgut    6 Adult Malpighian Tubules    2.8 Adult Fat Body    4.2 Adult Salivary Gland    1.8 Adult Heart    0.875 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    2 Adult Testis    11.3 Adult Male Accessory Gland    2.3 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    5.6 Larval Hindgut    2.7 Larval Malpighian Tubules    3.6 Larval Fat Body    7.6 Larval Salivary Gland    3.3 Larval Trachea    0.825 Larval Carcass    2.475 Adult Head    1.8 Adult Eye    1.275 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    4 Adult Midgut    8.8 Adult Hindgut    6 Adult Malpighian Tubules    2.8 Adult Fat Body    4.2 Adult Salivary Gland    1.8 Adult Heart    0.875 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    2 Adult Testis    11.3 Adult Male Accessory Gland    2.3 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.125 Larval Midgut    5.6 Larval Hindgut    2.7 Larval Malpighian Tubules    3.6 Larval Fat Body    7.6 Larval Salivary Gland    3.3 Larval Trachea    0.825 Larval Carcass    2.475 Adult Head    1.8 Adult Eye    1.275 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    4 Adult Midgut    8.8 Adult Hindgut    6 Adult Malpighian Tubules    2.8 Adult Fat Body    4.2 Adult Salivary Gland    1.8 Adult Heart    0.875 Adult VirginFemale Spermatheca    5.4 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    2 Adult Testis    11.3 Adult Male Accessory Gland    2.3 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1.8   NA  Eye    1.275   NA  Brain    2.7   2.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.8   NA  Crop    4   5.6  Midgut    8.8   2.7  Hindgut    6   3.6  Malpighian Tubules    2.8   7.6  Fat Body    4.2   3.3  Salivary Gland    1.8   NA  Heart    0.875   0.825  Trachea    NA   NA  VirginFemale Spermatheca    5.4   NA  InseminatedFemale Spermatheca    4.6   NA  Ovary    2   NA  Testis    no informative data   NA  Male Accessory Gland    2.3   2.475  Carcass    3.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045479 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32261-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Gr64aGE24923 Sterility Allele fertile Gr64aGE24923 Other Phenotypes Allele neurophysiology defective | adult stage Gr64a1 neurophysiology defective | adult stage (with Df(3L)GN34) Gr64a1 neurophysiology defective | adult stage (with Df(3L)Gr64a2) Gr64a1 proboscis extension reflex defective Gr64a1 proboscis extension reflex defective (with Df(3L)Gr64a2) Gr64a1 Phenotype manifest in Allele large labellar taste bristle Gr64a1 large labellar taste bristle (with Df(3L)GN34) Gr64a1 large labellar taste bristle (with Df(3L)Gr64a2) Gr64a1
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Gr64a Class Mutagen Stocks Known lesion Gr64a1 amorphic allele - genetic evidence Delta2-3 0 Yes Gr64aGE24923 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gr64a Class Mutagen Stocks Known lesion Gr64aKK112930 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gr64aScer\UAS.cJa in vitro construct - regulatory fusion 1 Yes Gr64aGD445 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Gr64aScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes Gr64aScer\UAS.T:Avic\GFP-EGFP 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6099 (Ryder, 2004.4.26) Df(3L)Gr64ab (Jiao et al., 2007, Jiao et al., 2007) Df(3L)Gr64a2 (Dahanukar et al., 2007) Df(3L)ΔGr64 (Slone et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD445} NA P{KK112930} NA P{UAS_Gr64abcdf.GFP} NA P{UAS-Gr64a.D} NA P{UAS-Gr64a.J} NA GAL4 construct P{Gr64a-GAL4.1.6} No P{Gr64a-GAL4.S} No
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Gr64aGE24923 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
sweet taste receptor activity inferred from mutant phenotype (Jiao et al., 2007, Dahanukar et al., 2007)
Biological Process
CV term Evidence References
detection of chemical stimulus involved in sensory perception of taste inferred from genetic interaction with Gr64f (Jiao et al., 2008) detection of glucose inferred from mutant phenotype (Jiao et al., 2007) detection of maltose stimulus inferred from mutant phenotype (Jiao et al., 2007) detection of sucrose stimulus inferred from mutant phenotype (Jiao et al., 2007) proboscis extension reflex inferred from mutant phenotype (Dahanukar et al., 2007) sensory perception of sweet taste inferred from genetic interaction with Gr64b, Gr64c, Gr64d, Gr64e, Gr64f (Slone et al., 2007) inferred from mutant phenotype (Jiao et al., 2007, Dahanukar et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
taste receptor activity inferred from sequence or structural similarity (Clyne et al., 2000) non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) non-traceable author statement (assigned by UniProtKB) (Dunipace et al., 2001)
Biological Process
CV term Evidence References
sensory perception of taste inferred from sequence or structural similarity (Clyne et al., 2000) non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) non-traceable author statement (assigned by UniProtKB) (Dunipace et al., 2001)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR009318 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) non-traceable author statement (assigned by UniProtKB) (Dunipace et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gr64a allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0045479
Orthologs
OrthoDB Orthologs (94) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6D53HM Dipteran inclusive ortholog search EOG6TTGSF Insect inclusive ortholog search EOG6GHXK9 Arthropod inclusive ortholog search EOG6QV9T9 Metazoa inclusive ortholog search EOG6V4G1X
Orthologs in Drosophila Species (EOG6D53HM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gr64a     Drosophila simulans   Dsim\GD13799 Y   Drosophila sechellia   Dsec\GM14609 Y   Drosophila erecta   Dere\GG15178 Y   Drosophila yakuba   Dyak\GE21397 Y   Drosophila ananassae   Dana\GF10085 Y   Drosophila pseudoobscura pseudoobscura   Dpse\Gr64a Y   Drosophila persimilis   Dper\GL16976 Y   Drosophila willistoni   Dwil\GK17552 Y   Drosophila virilis   Dvir\GJ11734 Y   Drosophila mojavensis   Dmoj\GI13880 Y   Drosophila grimshawi   Dgri\GH13957     Drosophila grimshawi   Dgri\GH14559 Y
Orthologs in non-Drosophila Dipterans (EOG6TTGSF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000060 Y Anopheles gambiae Malaria mosquito  Agam\GPRGR21 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ800009 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ800017 Y
Orthologs in non-Dipteran Insects (EOG6GHXK9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44499 Y Apis mellifera Western honey bee  Amel\GB41360 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037091 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006907 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15591 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15590 Y Atta cephalotes Leafcutter ant  Acep\ACEP17798 Y Atta cephalotes Leafcutter ant  Acep\ACEP17801 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19160 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19161 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22306 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22312 Y Linepithema humile Argentine ant  Lhum\LH13968 Y Linepithema humile Argentine ant  Lhum\LH24990 Y Linepithema humile Argentine ant  Lhum\LH14676 Y Linepithema humile Argentine ant  Lhum\LH14675 Y Linepithema humile Argentine ant  Lhum\LH14807 Y Linepithema humile Argentine ant  Lhum\LH12478 Y Linepithema humile Argentine ant  Lhum\LH14798 Y Linepithema humile Argentine ant  Lhum\LH14802 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB12451 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB12454 Y Solenopsis invicta Red fire ant  Sinv\SINV10725 Y Solenopsis invicta Red fire ant  Sinv\SINV10724 Y Solenopsis invicta Red fire ant  Sinv\SINV10731 Y Solenopsis invicta Red fire ant  Sinv\SINV10736 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007481 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI50348 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI38582 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI50351 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI063391 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003665 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003416 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000213 Y Tribolium castaneum Red flour beetle  Tcas\TcGr18 Y Tribolium castaneum Red flour beetle  Tcas\TcGr12 Y Tribolium castaneum Red flour beetle  Tcas\TcGr14 Y Tribolium castaneum Red flour beetle  Tcas\TcGr15 Y Tribolium castaneum Red flour beetle  Tcas\TcGr16 Y Tribolium castaneum Red flour beetle  Tcas\TcGr19 Y Tribolium castaneum Red flour beetle  Tcas\TcGr5 Y Tribolium castaneum Red flour beetle  Tcas\TcGr8 Y Tribolium castaneum Red flour beetle  Tcas\TcGr6 Y Tribolium castaneum Red flour beetle  Tcas\TcGr7 Y Tribolium castaneum Red flour beetle  Tcas\gr7 Y Tribolium castaneum Red flour beetle  Tcas\TcGr9 Y Tribolium castaneum Red flour beetle  Tcas\TcGr17 Y Tribolium castaneum Red flour beetle  Tcas\TcGr11 Y Tribolium castaneum Red flour beetle  Tcas\TcGr13 Y
Orthologs in non-Insect Arthropods (EOG6QV9T9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\matK Y Daphnia pulex Water flea  Dpux\DpuGr55 Y Daphnia pulex Water flea  Dpux\DpuGr57 Y Ixodes scapularis Deer tick  Isca\ISCW002110 Y Ixodes scapularis Deer tick  Isca\ISCW800168 Y Ixodes scapularis Deer tick  Isca\ISCW800179 Y Ixodes scapularis Deer tick  Isca\ISCW800182 Y Ixodes scapularis Deer tick  Isca\ISCW018232 Y Ixodes scapularis Deer tick  Isca\ISCW800184 Y Ixodes scapularis Deer tick  Isca\ISCW800176 Y Ixodes scapularis Deer tick  Isca\ISCW800175 Y Ixodes scapularis Deer tick  Isca\ISCW011821 Y Ixodes scapularis Deer tick  Isca\ISCW800181 Y Ixodes scapularis Deer tick  Isca\ISCW011822 Y Ixodes scapularis Deer tick  Isca\ISCW800178 Y Ixodes scapularis Deer tick  Isca\ISCW012263 Y Ixodes scapularis Deer tick  Isca\ISCW800173 Y Ixodes scapularis Deer tick  Isca\ISCW800169 Y Ixodes scapularis Deer tick  Isca\ISCW800180 Y Ixodes scapularis Deer tick  Isca\ISCW800177 Y Ixodes scapularis Deer tick  Isca\ISCW800163 Y Ixodes scapularis Deer tick  Isca\ISCW800170 Y Ixodes scapularis Deer tick  Isca\ISCW018260 Y Ixodes scapularis Deer tick  Isca\ISCW800166 Y Ixodes scapularis Deer tick  Isca\ISCW800167 Y
Orthologs in non-Arthropod Metazoa (EOG6V4G1X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\K09E4.5 Y Caenorhabditis elegans Nematode  Cele\gur-3 Y Caenorhabditis elegans Nematode  Cele\gur-5 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13799 Drosophila sechellia Dsec\GM14609 Drosophila erecta Dere\GG15178 Drosophila yakuba Dyak\GE21397 Drosophila ananassae Dana\GF10085 Drosophila pseudoobscura pseudoobscura Dpse\Gr64a Drosophila persimilis Dper\GL16976 Drosophila willistoni Dwil\GK17552 Drosophila virilis Dvir\GJ11734 Drosophila mojavensis Dmoj\GI13880 Drosophila grimshawi Dgri\GH14559
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	25080 w*; P{UAS-Gr64a.J}2/CyO; TM6B, Tb1/MKRS
VDRC	v103342 P{KK112930}VIE-260B
Genomic Clones ( 1 )
	BACR09C02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	DMG3-chr3L.5723.pred.a
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0045479 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117481
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Annotation CG14986 split into CG32261 (Gr64a), CG32257 (Gr64b) and CG32256 (Gr64c) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Gr64a is required for the behavioral responses to glucose, sucrose, and maltose. (Jiao et al., 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168048 RefSeq (Proteins) • NP_728920 DDBJ / EMBL / GenBank • AAN11576 Entrez Gene - A searchable database of RefSeq genes. • 117481 UniProtKB/Swiss-Prot • P83293
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Gustatory receptor (IPR009318)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0045479 DRSC - Results from RNAi screens. • FBgn0045479 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045479 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32261-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0045479 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117481 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/gr64a.htm modMine - Data generated by the modENCODE project. • FBgn0045479
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG14986 (Dunipace et al., 2001, ) CG32261 (Keleman et al., 2009.8.5) Dmel64a (Kent and Robertson, 2009) Gr64 (Chatterjee et al., 2010) Gr64a (Jiao et al., 2007, McBride et al., 2007, Dus et al., 2011, Slone et al., 2007, Dahanukar et al., 2007, Jiao et al., 2008, Zhou et al., 2009, Chatterjee et al., 2010, Weiss et al., 2011, Thorne et al., 2005, Colomb et al., 2007, Nishimura et al., 2012) Gr64A1 (Scott and Axel, 2001.4.25) GrLU3 (Scott and Axel, 2001.4.25) GRLU.3   LU.3 (Clyne et al., 2000)
Name Synonym	Gustatory receptor 64a (Robertson, 2001.11.11) Gustatory receptor LU.3 (Clyne et al., 2000)
Secondary FlyBase IDs
	FBgn0035485 FBgn0041217 FBgn0052261
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 2 ) Review  ( 2 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 )
Recent research papers ( 6 )
	Linford et al., 2012, PLoS Genet. 8(5): e1002668 Re-Patterning Sleep Architecture in Drosophila through Gustatory Perception and Nutritional Quality. [FBrf0218228] Nishimura et al., 2012, J. Neurogenet. 26(2): 206--215 Starvation-Induced Elevation of Taste Responsiveness and Expression of a Sugar Taste Receptor Gene in Drosophila melanogaster. [FBrf0218918] Dus et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(28): 11644--11649 Taste-independent detection of the caloric content of sugar in Drosophila. [FBrf0214346] Park and Kwon, 2011, PLoS ONE 6(12): e29022 Heterogeneous expression of Drosophila gustatory receptors in enteroendocrine cells. [FBrf0217097] Weiss et al., 2011, Neuron 69(2): 258--272 The Molecular and Cellular Basis of Bitter Taste in Drosophila. [FBrf0212834] Wisotsky et al., 2011, Nat. Neurosci. 14(12): 1534--1541 Evolutionary differences in food preference rely on Gr64e, a receptor for glycerol. [FBrf0216771] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...