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Gene Dmel\Gr28b

General Information
Symbol	Dmel\Gr28b	Species	D. melanogaster
Name	Gustatory receptor 28b	Annotation symbol	CG13788
Feature type	protein_coding_gene	FlyBase ID	FBgn0045495
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Gr28bE, Gr28b.e, Gr28b.d, Gr28b.a, Gr28bA, Gr28bD, Gr28A3, Gr28bC, Gr28bB, Gr28b.c
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	28A1-28A1	Sequence location	2L:7,454,826..7,462,247 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Gustatory receptor 28b is referred to in FlyBase by the symbol Dmel\Gr28b (CG13788, FBgn0045495). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: taste receptor activity. There is experimental evidence that it is involved in the biological process: immune response; melanization defense response; feeding behavior; defense response to bacterium. 5 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: 7TM chemoreceptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1638594_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of Gr28b. Gene sequence location is 2L:7454826..7462247.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 28A1-28A1   Limits computationally determined from genome sequence between P{PZ}cuc10607 and P{EP}EP2419EP2419&P{EP}EP575
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gr28b for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Gene model based on FBrf0141780.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gr28b-RA FBtr0079458  NM_139357   1541   452 Gr28b-RB FBtr0079459  NM_205921   1585   443 Gr28b-RC FBtr0079460  NM_205920   1595   470 Gr28b-RD FBtr0079461  NM_205919   1505   440 Gr28b-RE FBtr0079462  NM_205918   1526   447
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gr28b-PA   FBpp0079086   51.6   452   9.36     NP_647614   AAF52520 Gr28b-PB   FBpp0089144   50.5   443   9.59     NP_995643   AAS64648 Gr28b-PC   FBpp0089145   53.6   470   9.28     NP_995642   AAS64649 Gr28b-PD   FBpp0089142   50.5   440   9.08     NP_995641   AAS64650 Gr28b-PE   FBpp0089143   50.4   447   9.58     NP_995640   AAS64651
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • 7TM chemoreceptor (IPR013604)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52520   AE014134 AAS64648   AE014134 AAS64649   AE014134 AAS64650   AE014134 AAS64651   AX058783 CAC22576   BT029037   CZ467529   CZ467530   EL871341   EL871458
UniProtKB/Swiss-Prot	Q9VM08
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   gustatory receptor neuron of labellum   (Scott et al., 2001)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    11.2 Larval Midgut    11.7 Larval Hindgut    5 Larval Malpighian Tubules    6 Larval Fat Body    6.9 Larval Salivary Gland    7.4 Larval Trachea    4.4 Larval Carcass    8.475 Adult Head    11.2 Adult Eye    4.5 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    51.5 Adult Crop    4.6 Adult Midgut    2.8 Adult Hindgut    6.3 Adult Malpighian Tubules    4.5 Adult Fat Body    7.9 Adult Salivary Gland    17.7 Adult Heart    5.1 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    2 Adult Testis    3.2 Adult Male Accessory Gland    9.1 Adult Carcass    10.5 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    11.2 Larval Midgut    11.7 Larval Hindgut    5 Larval Malpighian Tubules    6 Larval Fat Body    6.9 Larval Salivary Gland    7.4 Larval Trachea    4.4 Larval Carcass    8.475 Adult Head    11.2 Adult Eye    4.5 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    51.5 Adult Crop    4.6 Adult Midgut    2.8 Adult Hindgut    6.3 Adult Malpighian Tubules    4.5 Adult Fat Body    7.9 Adult Salivary Gland    17.7 Adult Heart    5.1 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    2 Adult Testis    3.2 Adult Male Accessory Gland    9.1 Adult Carcass    10.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    11.2 Larval Midgut    11.7 Larval Hindgut    5 Larval Malpighian Tubules    6 Larval Fat Body    6.9 Larval Salivary Gland    7.4 Larval Trachea    4.4 Larval Carcass    8.475 Adult Head    11.2 Adult Eye    4.5 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    51.5 Adult Crop    4.6 Adult Midgut    2.8 Adult Hindgut    6.3 Adult Malpighian Tubules    4.5 Adult Fat Body    7.9 Adult Salivary Gland    17.7 Adult Heart    5.1 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    2 Adult Testis    3.2 Adult Male Accessory Gland    9.1 Adult Carcass    10.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    11.2 Larval Midgut    11.7 Larval Hindgut    5 Larval Malpighian Tubules    6 Larval Fat Body    6.9 Larval Salivary Gland    7.4 Larval Trachea    4.4 Larval Carcass    8.475 Adult Head    11.2 Adult Eye    4.5 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    51.5 Adult Crop    4.6 Adult Midgut    2.8 Adult Hindgut    6.3 Adult Malpighian Tubules    4.5 Adult Fat Body    7.9 Adult Salivary Gland    17.7 Adult Heart    5.1 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    2 Adult Testis    3.2 Adult Male Accessory Gland    9.1 Adult Carcass    10.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    11.2 Larval Midgut    11.7 Larval Hindgut    5 Larval Malpighian Tubules    6 Larval Fat Body    6.9 Larval Salivary Gland    7.4 Larval Trachea    4.4 Larval Carcass    8.475 Adult Head    11.2 Adult Eye    4.5 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    51.5 Adult Crop    4.6 Adult Midgut    2.8 Adult Hindgut    6.3 Adult Malpighian Tubules    4.5 Adult Fat Body    7.9 Adult Salivary Gland    17.7 Adult Heart    5.1 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    2 Adult Testis    3.2 Adult Male Accessory Gland    9.1 Adult Carcass    10.5 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    11.2 Larval Midgut    11.7 Larval Hindgut    5 Larval Malpighian Tubules    6 Larval Fat Body    6.9 Larval Salivary Gland    7.4 Larval Trachea    4.4 Larval Carcass    8.475 Adult Head    11.2 Adult Eye    4.5 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    51.5 Adult Crop    4.6 Adult Midgut    2.8 Adult Hindgut    6.3 Adult Malpighian Tubules    4.5 Adult Fat Body    7.9 Adult Salivary Gland    17.7 Adult Heart    5.1 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    2 Adult Testis    3.2 Adult Male Accessory Gland    9.1 Adult Carcass    10.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    11.2 Larval Midgut    11.7 Larval Hindgut    5 Larval Malpighian Tubules    6 Larval Fat Body    6.9 Larval Salivary Gland    7.4 Larval Trachea    4.4 Larval Carcass    8.475 Adult Head    11.2 Adult Eye    4.5 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    51.5 Adult Crop    4.6 Adult Midgut    2.8 Adult Hindgut    6.3 Adult Malpighian Tubules    4.5 Adult Fat Body    7.9 Adult Salivary Gland    17.7 Adult Heart    5.1 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    2 Adult Testis    3.2 Adult Male Accessory Gland    9.1 Adult Carcass    10.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    11.2 Larval Midgut    11.7 Larval Hindgut    5 Larval Malpighian Tubules    6 Larval Fat Body    6.9 Larval Salivary Gland    7.4 Larval Trachea    4.4 Larval Carcass    8.475 Adult Head    11.2 Adult Eye    4.5 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    51.5 Adult Crop    4.6 Adult Midgut    2.8 Adult Hindgut    6.3 Adult Malpighian Tubules    4.5 Adult Fat Body    7.9 Adult Salivary Gland    17.7 Adult Heart    5.1 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    2 Adult Testis    3.2 Adult Male Accessory Gland    9.1 Adult Carcass    10.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    11.2   NA  Eye    4.5   NA  Brain    13.9   11.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    51.5   NA  Crop    4.6   no informative data  Midgut    2.8   5  Hindgut    6.3   6  Malpighian Tubules    4.5   6.9  Fat Body    7.9   7.4  Salivary Gland    no informative data   NA  Heart    5.1   4.4  Trachea    NA   NA  VirginFemale Spermatheca    2.5   NA  InseminatedFemale Spermatheca    2.9   NA  Ovary    2   NA  Testis    3.2   NA  Male Accessory Gland    9.1   8.475  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045495 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13788-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Gr28bc01884 viable, with Scer\GAL4pnr-MD237 Gr28bGD588 Sterility Allele fertile Gr28bc01884 Other Phenotypes Allele feeding behavior defective Gr28bc01884 immune response defective | conditional Gr28bc01884 long lived Gr28bc01884 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Gr28b Class Mutagen Stocks Known lesion Gr28bc01884 piggyBac transposase 2 -- Gr28bMB03888 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gr28b Class Mutagen Stocks Known lesion Gr28bGD588 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gr28bKK105653 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gr28b+t14.5 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7031 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data GAL4 construct P{Gr28b.a-GAL4.3} No P{Gr28b.a-GAL4} No P{Gr28b.b-GAL4.4.7} No P{Gr28b.b-GAL4} No P{Gr28b.c-GAL4.6.5} No P{Gr28b.c-GAL4} No P{Gr28b.d-GAL4} No UAS construct P{GD588} NA P{KK105653} NA characterization construct P{Gr28a.14.5} NA P{Gr28b.e-GAL4.4.245} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Gr28bc01884 NA insertion of enhancer trap binary system Mi{ET1}Gr28bMB03888 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
defense response to bacterium inferred from mutant phenotype (Ayres et al., 2008) feeding behavior inferred from mutant phenotype (Ayres and Schneider, 2009) immune response inferred from mutant phenotype (Ayres and Schneider, 2009) melanization defense response inferred from mutant phenotype (Ayres and Schneider, 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
taste receptor activity inferred from sequence or structural similarity (Clyne et al., 2000) non-traceable author statement (assigned by UniProtKB) (Dunipace et al., 2001)
Biological Process
CV term Evidence References
sensory perception of taste inferred from electronic annotation with InterPro:IPR013604 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Clyne et al., 2000) non-traceable author statement (assigned by UniProtKB) (Dunipace et al., 2001)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR013604 (FlyBase Curators et al., 2004-) non-traceable author statement (assigned by UniProtKB) (Dunipace et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gr28b allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72917 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0045495 DroID - A comprehensive database of gene and protein interactions. • FBgn0045495 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117496
Orthologs
OrthoDB Orthologs (64) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PVPJ5 Dipteran inclusive ortholog search EOG698V7X Insect inclusive ortholog search EOG67H4K2 Arthropod inclusive ortholog search EOG6BG79Z Metazoa inclusive ortholog search EOG62NWS8
Orthologs in Drosophila Species (EOG6PVPJ5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gr28b     Drosophila simulans   Dsim\GD22492 Y   Drosophila sechellia   Dsec\GM13551 Y   Drosophila erecta   Dere\GG23530 Y   Drosophila yakuba   Dyak\GE18356 Y   Drosophila ananassae   Dana\GF14022 Y   Drosophila pseudoobscura pseudoobscura   Dpse\Gr28b Y   Drosophila persimilis   Dper\GL25929 Y   Drosophila willistoni   Dwil\GK24721 Y   Drosophila virilis   Dvir\GJ17606 Y   Drosophila mojavensis   Dmoj\GI17781 Y   Drosophila grimshawi   Dgri\GH13142 Y   Drosophila grimshawi   Dgri\GH10568
Orthologs in non-Drosophila Dipterans (EOG698V7X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011073 Y Anopheles gambiae Malaria mosquito  Agam\GPRGR33 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005986 Y
Orthologs in non-Dipteran Insects (EOG67H4K2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037202 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG036952 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037069 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037122 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037057 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005876 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037052 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037064 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG036996 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037058 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037060 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037055 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037062 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037050 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037065 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037053 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17802 Y Atta cephalotes Leafcutter ant  Acep\ACEP15680 Y Solenopsis invicta Red fire ant  Sinv\SINV14031 Y Solenopsis invicta Red fire ant  Sinv\SINV25817 Y Solenopsis invicta Red fire ant  Sinv\SINV14020 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI55988 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI23618 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI083215 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI56686 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI084864 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011447 Y Tribolium castaneum Red flour beetle  Tcas\TcGr154 Y Tribolium castaneum Red flour beetle  Tcas\gr24 Y Tribolium castaneum Red flour beetle  Tcas\TcGr121 Y Tribolium castaneum Red flour beetle  Tcas\TcGr89 Y Tribolium castaneum Red flour beetle  Tcas\TcGr119 Y Tribolium castaneum Red flour beetle  Tcas\TcGr118 Y Tribolium castaneum Red flour beetle  Tcas\TcGr122 Y
Orthologs in non-Insect Arthropods (EOG6BG79Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\Dpugr41 Y Daphnia pulex Water flea  Dpux\JGI_V11_321432 Y Daphnia pulex Water flea  Dpux\DpuGr39 Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\MRGPRF Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\JGI_V11_346875 Y Ixodes scapularis Deer tick  Isca\ISCW800164 Y
Orthologs in non-Arthropod Metazoa (EOG62NWS8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\lite-1 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22492 Drosophila sechellia Dsec\GM13551 Drosophila erecta Dere\GG23530 Drosophila yakuba Dyak\GE18356 Drosophila ananassae Dana\GF14022 Drosophila pseudoobscura pseudoobscura Dpse\Gr28b Drosophila persimilis Dper\GL25929 Drosophila willistoni Dwil\GK24721 Drosophila virilis Dvir\GJ17606 Drosophila mojavensis Dmoj\GI17781 Drosophila grimshawi Dgri\GH13142
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	10743 w1118; PBac{PB}Gr28bc01884 24190 w1118; Mi{ET1}Gr28bMB03888
Harvard	- PBac{PB}Gr28bc01884
VDRC	v101727 P{KK105653}VIE-260B v4843 w1118; P{GD588}v4843
Genomic Clones ( 1 )
	BACR30I17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03356
Other clones	DPiM_IP03356
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP03456 IP03556
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0045495 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117496
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139357 NM_205918 NM_205919 NM_205920 NM_205921 RefSeq (Proteins) • NP_647614 NP_995640 NP_995641 NP_995642 NP_995643 DDBJ / EMBL / GenBank • AAF52520 AAS64648 AAS64649 AAS64650 AAS64651 AX058783 CAC22576 CZ467529 CZ467530 Entrez Gene - A searchable database of RefSeq genes. • 117496 UniProtKB/Swiss-Prot • Q9VM08
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • 7TM chemoreceptor (IPR013604)
Linkouts
	BioGRID - A database of protein and genetic interactions • 72917 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0045495 DroID - A comprehensive database of gene and protein interactions. • FBgn0045495 DRSC - Results from RNAi screens. • FBgn0045495 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045495 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13788-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0045495 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117496 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117496 modMine - Data generated by the modENCODE project. • FBgn0045495
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	28A3 (Smith, 2001) CG13788 (Ayres et al., 2008, Robertson, 2003.6.22, Dunipace et al., 2001, Keleman et al., 2009.8.5) Gr28A3 (Millburn, 2001.4.25, Scott and Axel, 2001.4.25, Scott et al., 2001) Gr28A4 (Scott and Axel, 2001.4.25, ) gr28b (Ayres et al., 2008, Ayres and Schneider, 2009) Gr28b (Turner et al., 2008, Zhou et al., 2009, Thorne and Amrein, 2008, Xiang et al., 2010) Gr28b.a (Robertson, 2001.11.11, Thorne and Amrein, 2008, Weiss et al., 2011, Weiss et al., 2011) Gr28b.b (Robertson, 2001.11.11, Thorne and Amrein, 2008) Gr28b.c (Robertson, 2001.11.11, Thorne and Amrein, 2008) Gr28b.d (Robertson, 2001.11.11, Thorne and Amrein, 2008, Weiss et al., 2011, Weiss et al., 2011) Gr28b.e (Robertson, 2001.11.11, Thorne and Amrein, 2008, Weiss et al., 2011, Weiss et al., 2011) Gr28bA (Amrein and Thorne, 2005, McBride et al., 2007, Inomata et al., 2008) Gr28bB (Amrein and Thorne, 2005, McBride et al., 2007) Gr28bC (Amrein and Thorne, 2005, McBride et al., 2007) Gr28bD (Amrein and Thorne, 2005, McBride et al., 2007, Inomata et al., 2008) Gr28bE (Amrein and Thorne, 2005, McBride et al., 2007) Gr28be (Thorne et al., 2004, Colomb and Stocker, 2007, Thorne et al., 2005, Colomb et al., 2007) GrLU2 (Scott and Axel, 2001.4.25) GRLU.2   LU.2 (Clyne et al., 2000)
Name Synonym	Gustatory receptor 28A4 (Scott and Axel, 2001.4.25) Gustatory receptor 28b (Robertson, 2001.11.11) Gustatory receptor LU.2 (Clyne et al., 2000)
Secondary FlyBase IDs
	FBgn0031917 FBgn0041218 FBgn0045496
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 12 ) Patent  ( 1 )
Recent research papers ( 4 )
	Kwon et al., 2011, J. Neurosci. 31(43): 15300--15309 Molecular and cellular organization of the taste system in the Drosophila larva. [FBrf0216529] Park and Kwon, 2011, PLoS ONE 6(12): e29022 Heterogeneous expression of Drosophila gustatory receptors in enteroendocrine cells. [FBrf0217097] Park and Kwon, 2011, Mol. Cells 32(4): 375--381 A systematic analysis of Drosophila gustatory receptor gene expression in abdominal neurons which project to the central nervous system. [FBrf0216510] Weiss et al., 2011, Neuron 69(2): 258--272 The Molecular and Cellular Basis of Bitter Taste in Drosophila. [FBrf0212834] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...