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Gene Dmel\CHKov1

General Information
Symbol	Dmel\CHKov1	Species	D. melanogaster
Name	CHKov1	Annotation symbol	CG10618
Feature type	protein_coding_gene	FlyBase ID	FBgn0045761
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96D1-96D1	Sequence location	3R:21,148,876..21,155,024 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene CHKov1 is referred to in FlyBase by the symbol Dmel\CHKov1 (CG10618, FBgn0045761). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: RNA binding; RNA-directed DNA polymerase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: RNA-dependent DNA replication. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; tormogen cell. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: CHK kinase-like; Endonuclease/exonuclease/phosphatase; Protein kinase-like domain; Protein of unknown function DUF227; Reverse transcriptase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624272_at partially aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of CHKov1: 12 out of 13 probes fall into this exonic region. Gene sequence location is 3R:21148876..21155024.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA01696 BKN46594 HFA14258 BKN27093 HFA20937 HFA01566 References Magwire et al., 2011, PLoS Genet. 7(10): e1002337
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96D1-96D1   Limits computationally determined from genome sequence between P{PZ}Aats-gln05461 and P{EP}EP3354
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CHKov1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Mutation in sequenced strain: CHKov1[Doc1420], insertion of Doc element. Mutant allele found in wild-type strains, reported to support transcription and production of truncated protein product(s) (FBrf0188316).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CHKov1-RB FBtr0113349  NM_143129   571   139 CHKov1-RC FBtr0113350  NM_001104446   564   121 CHKov1-RD FBtr0113351  NM_001104447   555   184 CHKov1-RE FBtr0113352  NM_001104448   1300   410 CHKov1-RF FBtr0113353  NM_001104449   1261   397
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CHKov1-PB   FBpp0112261   16.1   139   9.10     NP_651386   AAF56457 CHKov1-PC   FBpp0112262   14.3   121   7.06     NP_001097916   ABW08756 CHKov1-PD   FBpp0112263   21.5   184   9.20     NP_001097917   ABW08757 CHKov1-PE   FBpp0112264   47.1   410   6.14     NP_001097918   ABW08758 CHKov1-PF   FBpp0112265   44.1   397   10.19     NP_001097919   ABW08759
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Reverse transcriptase (IPR000477) Endonuclease/exonuclease/phosphatase (IPR005135) Protein of unknown function DUF227 (IPR004119) Protein kinase-like domain (IPR011009) CHK kinase-like (IPR015897)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567852   AA696722   AA698571   AE014297 AAF56457   AE014297 ABW08756   AE014297 ABW08757   AE014297 ABW08758   AE014297 ABW08759   AI063779   AI113642   AI258494   AI259327   AI456694   AI517067   AI541729   AW940142   AY047531 AAK77263   BI612152   BI627374   BI633171   BI638385   BI638404   CA804464   CK659837   CO177650   CO184365   CO189271   CO189989   CO192074   CO263222   CO271451   CO271623   CO280819   CO281472   CO289197   CO304540   CO305880   CO308671   CO313540   CO313835   CO315331   CO320077   CO322445   CO332468   CO332953   CO333996   CO341315   CO342160   EC224553   EC254721   ES690676   GH941190   GH943767   GH944946   GH946375   GH946610   GH946789   GH947459   GH948402   GH948969   GH949038   GH950276   GH950891   GH950989   GH951183   GH952731   GH952842   GH953090   GH954848   GH956990   GH957430   GH958026   GH960693   GH961193   GH961373   GH963130   GH964392   GH964525   GH966914   GH968989   GH969279   GH971236   GH973267   GH973586   GH974060   GH976917   GH978004   GH978064   GH978096   GH978302   GH978651   GH979255   GH979605   GH979610   GH980778   GH981566   GH981752   GH982963   GH983482   GH985011
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q961V7 A8JRB2 A8JRB5 Q107I8 A8JRB1 A8JRB3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0045761    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0045761 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0045761 expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr    253 embryo 12-14hr    1061 embryo 14-16hr    843 embryo 16-18hr    636 embryo 18-20hr    503 embryo 20-22hr    514 embryo 22-24hr    708 larva L1    549 larva L2    1017 larva L3 12hr old    784 larva L3 puffstage 1-2    694 larva L3 puffstage 3-6    1029 larva L3 puffstage 7-9    1770 white prepupae new    1986 white prepupae 12hr    806 white prepupae 24hr    835 pupae 2d postWPP    1003 pupae 3d postWPP    661 pupae 4d postWPP    275 adult male 01day    592 adult male 05day    457 adult male 30day    334 adult female 01day    287 adult female 05day    128 adult female 30day    139 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr  (253) embryo 12-14hr  (1061) embryo 14-16hr  (843) embryo 16-18hr  (636) embryo 18-20hr  (503) embryo 20-22hr  (514) embryo 22-24hr  (708) larva L1  (549) larva L2  (1017) larva L3 12hr old  (784) larva L3 puffstage 1-2  (694) larva L3 puffstage 3-6  (1029) larva L3 puffstage 7-9  (1770) white prepupae new  (1986) white prepupae 12hr  (806) white prepupae 24hr  (835) pupae 2d postWPP  (1003) pupae 3d postWPP  (661) pupae 4d postWPP  (275) adult male 01day  (592) adult male 05day  (457) adult male 30day  (334) adult female 01day  (287) adult female 05day  (128) adult female 30day  (139) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr    253 embryo 12-14hr    1061 embryo 14-16hr    843 embryo 16-18hr    636 embryo 18-20hr    503 embryo 20-22hr    514 embryo 22-24hr    708 larva L1    549 larva L2    1017 larva L3 12hr old    784 larva L3 puffstage 1-2    694 larva L3 puffstage 3-6    1029 larva L3 puffstage 7-9  (1770) white prepupae new  (1986) white prepupae 12hr    806 white prepupae 24hr    835 pupae 2d postWPP    1003 pupae 3d postWPP    661 pupae 4d postWPP    275 adult male 01day    592 adult male 05day    457 adult male 30day    334 adult female 01day    287 adult female 05day    128 adult female 30day    139 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr    253 embryo 12-14hr    1061 embryo 14-16hr    843 embryo 16-18hr    636 embryo 18-20hr    503 embryo 20-22hr    514 embryo 22-24hr    708 larva L1    549 larva L2    1017 larva L3 12hr old    784 larva L3 puffstage 1-2    694 larva L3 puffstage 3-6    1029 larva L3 puffstage 7-9    1770 white prepupae new    1986 white prepupae 12hr    806 white prepupae 24hr    835 pupae 2d postWPP    1003 pupae 3d postWPP    661 pupae 4d postWPP    275 adult male 01day    592 adult male 05day    457 adult male 30day    334 adult female 01day    287 adult female 05day    128 adult female 30day    139 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr    253 embryo 12-14hr    1061 embryo 14-16hr    843 embryo 16-18hr    636 embryo 18-20hr    503 embryo 20-22hr    514 embryo 22-24hr    708 larva L1    549 larva L2    1017 larva L3 12hr old    784 larva L3 puffstage 1-2    694 larva L3 puffstage 3-6    1029 larva L3 puffstage 7-9    1770 white prepupae new    1986 white prepupae 12hr    806 white prepupae 24hr    835 pupae 2d postWPP    1003 pupae 3d postWPP    661 pupae 4d postWPP    275 adult male 01day    592 adult male 05day    457 adult male 30day    334 adult female 01day    287 adult female 05day    128 adult female 30day    139 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0045761 expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr    253 embryo 12-14hr    1061 embryo 14-16hr    843 embryo 16-18hr    636 embryo 18-20hr    503 embryo 20-22hr    514 embryo 22-24hr    708 larva L1    549 larva L2    1017 larva L3 12hr old    784 larva L3 puffstage 1-2    694 larva L3 puffstage 3-6    1029 larva L3 puffstage 7-9    1770 white prepupae new    1986 white prepupae 12hr    806 white prepupae 24hr    835 pupae 2d postWPP    1003 pupae 3d postWPP    661 pupae 4d postWPP    275 adult male 01day    592 adult male 05day    457 adult male 30day    334 adult female 01day    287 adult female 05day    128 adult female 30day    139 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr  (253) embryo 12-14hr  (1061) embryo 14-16hr  (843) embryo 16-18hr  (636) embryo 18-20hr  (503) embryo 20-22hr  (514) embryo 22-24hr  (708) larva L1  (549) larva L2  (1017) larva L3 12hr old  (784) larva L3 puffstage 1-2  (694) larva L3 puffstage 3-6  (1029) larva L3 puffstage 7-9  (1770) white prepupae new  (1986) white prepupae 12hr  (806) white prepupae 24hr  (835) pupae 2d postWPP  (1003) pupae 3d postWPP  (661) pupae 4d postWPP  (275) adult male 01day  (592) adult male 05day  (457) adult male 30day  (334) adult female 01day  (287) adult female 05day  128 adult female 30day  139 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr    253 embryo 12-14hr    1061 embryo 14-16hr    843 embryo 16-18hr    636 embryo 18-20hr    503 embryo 20-22hr    514 embryo 22-24hr    708 larva L1    549 larva L2    1017 larva L3 12hr old    784 larva L3 puffstage 1-2    694 larva L3 puffstage 3-6    1029 larva L3 puffstage 7-9  1770 white prepupae new  1986 white prepupae 12hr    806 white prepupae 24hr    835 pupae 2d postWPP    1003 pupae 3d postWPP    661 pupae 4d postWPP    275 adult male 01day    592 adult male 05day    457 adult male 30day    334 adult female 01day    287 adult female 05day    128 adult female 30day    139 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr    253 embryo 12-14hr    1061 embryo 14-16hr    843 embryo 16-18hr    636 embryo 18-20hr    503 embryo 20-22hr    514 embryo 22-24hr    708 larva L1    549 larva L2    1017 larva L3 12hr old    784 larva L3 puffstage 1-2    694 larva L3 puffstage 3-6    1029 larva L3 puffstage 7-9    1770 white prepupae new    1986 white prepupae 12hr    806 white prepupae 24hr    835 pupae 2d postWPP    1003 pupae 3d postWPP    661 pupae 4d postWPP    275 adult male 01day    592 adult male 05day    457 adult male 30day    334 adult female 01day    287 adult female 05day    128 adult female 30day    139 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    1 embryo 04-06hr    7 embryo 06-08hr    45 embryo 08-10hr    84 embryo 10-12hr    253 embryo 12-14hr    1061 embryo 14-16hr    843 embryo 16-18hr    636 embryo 18-20hr    503 embryo 20-22hr    514 embryo 22-24hr    708 larva L1    549 larva L2    1017 larva L3 12hr old    784 larva L3 puffstage 1-2    694 larva L3 puffstage 3-6    1029 larva L3 puffstage 7-9    1770 white prepupae new    1986 white prepupae 12hr    806 white prepupae 24hr    835 pupae 2d postWPP    1003 pupae 3d postWPP    661 pupae 4d postWPP    275 adult male 01day    592 adult male 05day    457 adult male 30day    334 adult female 01day    287 adult female 05day    128 adult female 30day    139 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0045761    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0045761 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0045761 expression level Tissue   Expression Level Larval Central Nervous System    57.45 Larval Midgut    188.8 Larval Hindgut    205 Larval Malpighian Tubules    238.3 Larval Fat Body    289 Larval Salivary Gland    332.9 Larval Trachea    377.45 Larval Carcass    250 Adult Head    121.9 Adult Eye    162.8 Adult Brain    81.9 Adult Thoracic-Abdominal Ganglion    130.7 Adult Crop    323.8 Adult Midgut    147.7 Adult Hindgut    162.1 Adult Malpighian Tubules    156.2 Adult Fat Body    204.1 Adult Salivary Gland    790.9 Adult Heart    175.425 Adult VirginFemale Spermatheca    158.2 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    3.2 Adult Testis    32.3 Adult Male Accessory Gland    332.8 Adult Carcass    224.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    57.45 Larval Midgut    188.8 Larval Hindgut    205 Larval Malpighian Tubules    238.3 Larval Fat Body    289 Larval Salivary Gland    332.9 Larval Trachea    377.45 Larval Carcass    250 Adult Head    121.9 Adult Eye    162.8 Adult Brain    81.9 Adult Thoracic-Abdominal Ganglion    130.7 Adult Crop    323.8 Adult Midgut    147.7 Adult Hindgut    162.1 Adult Malpighian Tubules    156.2 Adult Fat Body    204.1 Adult Salivary Gland  (790.9) Adult Heart    175.425 Adult VirginFemale Spermatheca    158.2 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    3.2 Adult Testis    32.3 Adult Male Accessory Gland    332.8 Adult Carcass    224.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    57.45 Larval Midgut    188.8 Larval Hindgut    205 Larval Malpighian Tubules    238.3 Larval Fat Body    289 Larval Salivary Gland    332.9 Larval Trachea    377.45 Larval Carcass    250 Adult Head    121.9 Adult Eye    162.8 Adult Brain    81.9 Adult Thoracic-Abdominal Ganglion    130.7 Adult Crop    323.8 Adult Midgut    147.7 Adult Hindgut    162.1 Adult Malpighian Tubules    156.2 Adult Fat Body    204.1 Adult Salivary Gland    790.9 Adult Heart    175.425 Adult VirginFemale Spermatheca    158.2 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    3.2 Adult Testis    32.3 Adult Male Accessory Gland    332.8 Adult Carcass    224.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    57.45 Larval Midgut    188.8 Larval Hindgut    205 Larval Malpighian Tubules    238.3 Larval Fat Body    289 Larval Salivary Gland    332.9 Larval Trachea    377.45 Larval Carcass    250 Adult Head    121.9 Adult Eye    162.8 Adult Brain    81.9 Adult Thoracic-Abdominal Ganglion    130.7 Adult Crop    323.8 Adult Midgut    147.7 Adult Hindgut    162.1 Adult Malpighian Tubules    156.2 Adult Fat Body    204.1 Adult Salivary Gland    790.9 Adult Heart    175.425 Adult VirginFemale Spermatheca    158.2 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    3.2 Adult Testis    32.3 Adult Male Accessory Gland    332.8 Adult Carcass    224.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0045761 expression level Tissue   Expression Level Larval Central Nervous System    57.45 Larval Midgut    188.8 Larval Hindgut    205 Larval Malpighian Tubules    238.3 Larval Fat Body    289 Larval Salivary Gland    332.9 Larval Trachea    377.45 Larval Carcass    250 Adult Head    121.9 Adult Eye    162.8 Adult Brain    81.9 Adult Thoracic-Abdominal Ganglion    130.7 Adult Crop    323.8 Adult Midgut    147.7 Adult Hindgut    162.1 Adult Malpighian Tubules    156.2 Adult Fat Body    204.1 Adult Salivary Gland    790.9 Adult Heart    175.425 Adult VirginFemale Spermatheca    158.2 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    3.2 Adult Testis    32.3 Adult Male Accessory Gland    332.8 Adult Carcass    224.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    57.45 Larval Midgut    188.8 Larval Hindgut    205 Larval Malpighian Tubules    238.3 Larval Fat Body    289 Larval Salivary Gland    332.9 Larval Trachea    377.45 Larval Carcass    250 Adult Head    121.9 Adult Eye    162.8 Adult Brain    81.9 Adult Thoracic-Abdominal Ganglion    130.7 Adult Crop    323.8 Adult Midgut    147.7 Adult Hindgut    162.1 Adult Malpighian Tubules    156.2 Adult Fat Body    204.1 Adult Salivary Gland  790.9 Adult Heart    175.425 Adult VirginFemale Spermatheca    158.2 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    3.2 Adult Testis    32.3 Adult Male Accessory Gland    332.8 Adult Carcass    224.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    57.45 Larval Midgut    188.8 Larval Hindgut    205 Larval Malpighian Tubules    238.3 Larval Fat Body    289 Larval Salivary Gland    332.9 Larval Trachea    377.45 Larval Carcass    250 Adult Head    121.9 Adult Eye    162.8 Adult Brain    81.9 Adult Thoracic-Abdominal Ganglion    130.7 Adult Crop    323.8 Adult Midgut    147.7 Adult Hindgut    162.1 Adult Malpighian Tubules    156.2 Adult Fat Body    204.1 Adult Salivary Gland    790.9 Adult Heart    175.425 Adult VirginFemale Spermatheca    158.2 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    3.2 Adult Testis    32.3 Adult Male Accessory Gland    332.8 Adult Carcass    224.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    57.45 Larval Midgut    188.8 Larval Hindgut    205 Larval Malpighian Tubules    238.3 Larval Fat Body    289 Larval Salivary Gland    332.9 Larval Trachea    377.45 Larval Carcass    250 Adult Head    121.9 Adult Eye    162.8 Adult Brain    81.9 Adult Thoracic-Abdominal Ganglion    130.7 Adult Crop    323.8 Adult Midgut    147.7 Adult Hindgut    162.1 Adult Malpighian Tubules    156.2 Adult Fat Body    204.1 Adult Salivary Gland    790.9 Adult Heart    175.425 Adult VirginFemale Spermatheca    158.2 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    3.2 Adult Testis    32.3 Adult Male Accessory Gland    332.8 Adult Carcass    224.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    121.9   NA  Eye    162.8   NA  Brain    81.9   57.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    130.7   NA  Crop    323.8   188.8  Midgut    147.7   205  Hindgut    162.1   238.3  Malpighian Tubules    156.2   289  Fat Body    204.1   332.9  Salivary Gland    790.9   NA  Heart    175.425   377.45  Trachea    NA   NA  VirginFemale Spermatheca    158.2   NA  InseminatedFemale Spermatheca    157.5   NA  Ovary    3.2   NA  Testis    32.3   NA  Male Accessory Gland    332.8   250  Carcass    224.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045761 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10618-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CHKov1GD7036 Other Phenotypes Allele chemical resistant CHKov1Doc1420 visible, with Scer\GAL4pnr-MD237 CHKov1GD7036 Phenotype manifest in Allele tormogen cell, with Scer\GAL4pnr-MD237 CHKov1GD7036 trichogen cell, with Scer\GAL4pnr-MD237 CHKov1GD7036
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of CHKov1 Class Mutagen Stocks Known lesion CHKov1KG02238 1 -- CHKov1NP3620 1 -- CHKov1NP5448 1 -- CHKov1Doc1420 natural population 0 Yes
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CHKov1 Class Mutagen Stocks Known lesion CHKov1GD7036 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6202 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7036} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}CHKov1NP3620 No P{GawB}CHKov1NP5448 No miscellaneous insertions P{SUPor-P}CHKov1KG02238 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
RNA binding inferred from electronic annotation with InterPro:IPR000477 (FlyBase Curators et al., 2004-) RNA-directed DNA polymerase activity inferred from electronic annotation with InterPro:IPR000477 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
RNA-dependent DNA replication inferred from electronic annotation with InterPro:IPR000477 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CHKov1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0045761
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA10440   Dsim\CHKov1 (Aminetzach et al., 2005) Dyak\CHKov1 (Aminetzach et al., 2005, Aminetzach et al., 2005.6.7)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • CN06916 Caenorhabditis brenneri (small nematode) CN08713 Caenorhabditis brenneri (small nematode) CN11777 Caenorhabditis brenneri (small nematode) CN29139 Caenorhabditis brenneri (small nematode) CN30571 Caenorhabditis brenneri (small nematode) CE33118 Caenorhabditis elegans (worm) CE33119 Caenorhabditis elegans (worm) JA14685 Caenorhabditis japonica (nematode) PHUM004341-PA Pediculus humanus (human body louse) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0084345 FBgn0189739 FBgn0172628 FBgn0104546
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	14084 y1 w67c23; ry506 P{SUPor-P}CHKov1KG02238
Kyoto	113376 w*; P{GawB}CHKov1NP3620 113739 w*; P{GawB}CHKov1NP5448 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v27290 w1118 P{GD7036}v27290
Genomic Clones ( 2 )
	BACR06L08 BACR10P10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 91 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH10039 GH27695 GM08252 HL01888 HL04945 LD36802 LP01707 LP02719 LP17908 RH40558 RH68665 SD06789 SD20661 SD20683 SD27175
Other clones	77893 EC27976 EC32787 EC254721 EK043736 EK045843 EK053963 EK070427 EK087820 EK103460 EK104058 EK154938 EK157245 EK188142 EK233327 EK234158 EK245039 EK249619 EK259058 EK261053 EK282104 EK303539 EK305234 EK308548 EP12239 EP13964 ESG0113c.B21.1_H03 RP004044616 RP004057849 RP004067409 RP004107524 RP004134698 RP004138659 RP004140243 RP004162254 RP004162919 RP004163487 RP004172469 RP004188244 RP004192481 RP004195896 RP004208918 RP004209382 RP004215753 RP004216139 RP004218875 RP004220503 RP004229056 RP004230544 RP004234263 RP004237548 RP004247907 RP004248767 RP004248855 RP004252642 RP004258492 RP004261346 RP004264026 RP004264734 RP004265474 RP004265748 RP004269532 RP004307405 RP004370653 RP004379122 RP004384452 RP004415910 RP004443915 RP004447712 RP004474581 RP004502361 RP004504329 RP004518390 RP004536025 RP004536923 RP004544064
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0045761 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43067
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CHKov1 CG10618 (Aminetzach et al., 2005)
Source for database merge of	Source for merge of: CG10618 BcDNA:GH03753 (FlyBase, 1996-)
Additional comments	Source for merge of CG10618 BcDNA:GH03753 was a shared cDNA (GH03753) (date:011030). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143129 NM_001104446 NM_001104447 NM_001104448 NM_001104449 RefSeq (Proteins) • NP_651386 NP_001097916 NP_001097917 NP_001097918 NP_001097919 DDBJ / EMBL / GenBank • AAF56457 AAK77263 ABW08756 ABW08757 ABW08758 ABW08759 AI063779 AW940142 AY047531 Entrez Gene - A searchable database of RefSeq genes. • 43067 UniProtKB/TrEMBL • A8JRB1 A8JRB2 A8JRB3 A8JRB5 Q107I8 Q961V7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Reverse transcriptase (IPR000477) Endonuclease/exonuclease/phosphatase (IPR005135) Protein of unknown function DUF227 (IPR004119) Protein kinase-like domain (IPR011009) CHK kinase-like (IPR015897)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0045761 DRSC - Results from RNAi screens. • FBgn0045761 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045761 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10618-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0045761 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43067 InParanoid A subset of ortholog calls from InParanoid. • CN06916 Caenorhabditis brenneri (small nematode) CN08713 Caenorhabditis brenneri (small nematode) CN11777 Caenorhabditis brenneri (small nematode) CN29139 Caenorhabditis brenneri (small nematode) CN30571 Caenorhabditis brenneri (small nematode) CE33118 Caenorhabditis elegans (worm) CE33119 Caenorhabditis elegans (worm) JA14685 Caenorhabditis japonica (nematode) PHUM004341-PA Pediculus humanus (human body louse) modMine - Data generated by the modENCODE project. • FBgn0045761 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0084345 FBgn0189739 FBgn0172628 FBgn0104546
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:GH03753   CG10618 (Aminetzach et al., 2005, Deloger et al., 2009, Wittkopp et al., 2004, González et al., 2008, Lipatov et al., 2005, Wittkopp et al., 2008) CHKov1 (ffrench-Constant et al., 2006, González et al., 2008)
Name Synonym	CHKov1
Secondary FlyBase IDs
	FBgn0039327
References ( 19 )
Research paper	Magwire et al., 2011, PLoS Genet. 7(10): e1002337 Successive Increases in the Resistance of Drosophila to Viral Infection through a Transposon Insertion Followed by a Duplication. [FBrf0216506] Deloger et al., 2009, Gene 439(1-2): 55--62 Identification of expressed transposable element insertions in the sequenced genome of Drosophila melanogaster. [FBrf0207990] González et al., 2008, PLoS Biol. 6(10): e251 High rate of recent transposable element-induced adaptation in Drosophila melanogaster. [FBrf0206197] Aminetzach et al., 2005, Science 309(5735): 764--767 Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila. [FBrf0188316] Lipatov et al., 2005, BMC Biol. 3: 24 Paucity of chimeric gene-transposable element transcripts in the Drosophila melanogaster genome. [FBrf0189752] Wittkopp et al., 2004, Nature 430(6995): 85--88 Evolutionary changes in cis and trans gene regulation. [FBrf0179517]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Wittkopp et al., 2008, Nat. Genet. 40(3): Supplementary Information [FBrf0208881]
Review	ffrench-Constant et al., 2006, BioEssays 28(1): 6--8 Resistance and the jumping gene. [FBrf0189798]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Aminetzach et al., 2005.6.7, GenBank/EMBL/DDBJ: DQ087641 Drosophila yakuba isolate yakuba001 CHKov1 (CG10618) mRNA, complete cds. [FBrf0199342] Stapleton, 2001.7.20, GenBank/EMBL/DDBJ: AY047531 Drosophila melanogaster GH03753 full length cDNA. [FBrf0137816]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]