• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\btz

General Information
Symbol	Dmel\btz	Species	D. melanogaster
Name	barentsz	Annotation symbol	CG12878
Feature type	protein_coding_gene	FlyBase ID	FBgn0045862
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	wkl
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	98B1-98B2	Sequence location	3R:23,525,986..23,529,174 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene barentsz is referred to in FlyBase by the symbol Dmel\btz (CG12878, FBgn0045862). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: translation initiation factor binding. There is experimental evidence that it is involved in the biological process: ribonucleoprotein complex assembly; pole plasm protein localization; pole plasm oskar mRNA localization; oocyte microtubule cytoskeleton polarization. 9 alleles are reported. The phenotypes of these alleles are annotated with: abdomen; embryonic/first instar larval cuticle; trichogen cell; pole cell; mesothoracic tergum; denticle belt. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: CASC3/Barentsz eIF4AIII binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval/adult salivary gland, larval trachea, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637956_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of btz. Gene sequence location is 3R:23525986..23529174.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN31083 HFA14566 BKN45994
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98B1-98B2   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98B1-98B2   (determined by in situ hybridisation)   (Spradling et al., 1999) 98B1-98B2     (BDGP Project Members, 1994-1999) 98A-98A   Determined by deficiency mapping (details unspecified).   (Weston and St, 1996)
Experimentally Determined Recombination Data
Location	3- (Weston and St, 1996)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\btz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic (LD37788): incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) btz-RA FBtr0085220  NM_079810   3116   761 btz-RB FBtr0085221  NM_170350   3028   782
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein btz-PA   FBpp0084590   83.7   761   5.18     NP_524534   AAF56741 btz-PB   FBpp0084591   86.1   782   5.33     NP_733229   AAN14126
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CASC3/Barentsz eIF4AIII binding (IPR018545)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439125   AE014297 AAF56741   AE014297 AAN14126   AI107188   AI297127   AI403803   AI455776   AI512398   AI518311   AI542736   AI546541   AQ026368   AW943397   AY051891 AAK93315   BF490055   BF491812   BF496917   BI242300   BI357968   BI364509   BI373924   BI629361   BI635493   BT056272   BT099786   CK656941   CK661270   CO279065   CO281789   CO282292   CO287219   CO296015   CO306295   CO329749   DN154047   EC058240   EC066684   EC067364   EC077300   EC222428   EC234252   EC239797   EC244524   EV597198   GH758522   GH773556   GH773896   GH802313   GH806451   GH808363   GH814884   GH822937   GH827235   GH849236   GH866651   GH878220   GH904484   GH907878   GH911170
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KRX5 Q960S3 Q9VB04
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage | female   germarium region 2   (van Eeden et al., 2001) adult stage | female & oogenesis   oocyte of germarium region 2b   (van Eeden et al., 2001) adult stage | femaleoogenesis stage S4 -- oogenesis stage S7   oocyte | posterior   (van Eeden et al., 2001) Comment:posterior enrichments begins to disperse at stage S6 adult stage | female & oogenesis stage S8   oocyte   • cytoplasm (van Eeden et al., 2001) adult stage | femaleoogenesis stage S4 -- oogenesis stage S9   nurse cell   • nuclear envelope | punctate (van Eeden et al., 2001) adult stage | female & oogenesis stage S9   oocyte | posterior   • cell cortex | posterior (van Eeden et al., 2001) ring canal | surrounding   (van Eeden et al., 2001) adult stage | female & oogenesis stage S10B   oocyte   • cytoplasm (van Eeden et al., 2001) Comment:transient posterior enrichment disperses during stage S10A western blot Stage Tissue/Position (including subcellular localization) Reference adult stage | female   ovary   (van Eeden et al., 2001) adult stage | femaleoogenesis stage S1 -- oogenesis stage S10   egg chamber   (van Eeden et al., 2001)
Additional Descriptive Data
	btz protein is first expressed in germarium region 2, then accumulates in oocytes in germarium region 2b. At oogenesis stage S4, btz is localized to the posterior of the oocyte, then begins to lose posterior enrichment at oogenesis stage S6. By oogenesis stage 8, btz protein has dispersed throughout the cytoplasm of the oocyte. At oogenesis stage S9, btz is again enriched at the posterior of the oocyte, then begins to disperse into the cytoplasm at the beginning of oogenesis stage S10; by oogenesis stage S10b btz is completely dispersed. From oogenesis stage S4, btz protein is also concentrated in a punctate pattern around the nuclei of nurse cells, with a similar distribution in follicle cells beginning at oogenesis stage S6; this pattern is suggestive of an association with the nuclear pores of these cells. btz protein colocalizes with mago in a dense cloud around the ring canals, and at the posterior pole of stage 9 oocytes. (van Eeden et al., 2001)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0045862    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0045862 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0045862 expression level Developmental Stage   Expression Level embryo 00-02hr    5989 embryo 02-04hr    1935 embryo 04-06hr    1451 embryo 06-08hr    2732 embryo 08-10hr    2152 embryo 10-12hr    2444 embryo 12-14hr    1840 embryo 14-16hr    2144 embryo 16-18hr    1021 embryo 18-20hr    943 embryo 20-22hr    834 embryo 22-24hr    664 larva L1    1011 larva L2    1231 larva L3 12hr old    977 larva L3 puffstage 1-2    714 larva L3 puffstage 3-6    1214 larva L3 puffstage 7-9    1033 white prepupae new    1236 white prepupae 12hr    1228 white prepupae 24hr    1474 pupae 2d postWPP    1456 pupae 3d postWPP    713 pupae 4d postWPP    666 adult male 01day    824 adult male 05day    917 adult male 30day    938 adult female 01day    2115 adult female 05day    3089 adult female 30day    3357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5989) embryo 02-04hr  (1935) embryo 04-06hr  (1451) embryo 06-08hr  (2732) embryo 08-10hr  (2152) embryo 10-12hr  (2444) embryo 12-14hr  (1840) embryo 14-16hr  (2144) embryo 16-18hr  (1021) embryo 18-20hr  (943) embryo 20-22hr  (834) embryo 22-24hr  (664) larva L1  (1011) larva L2  (1231) larva L3 12hr old  (977) larva L3 puffstage 1-2  (714) larva L3 puffstage 3-6  (1214) larva L3 puffstage 7-9  (1033) white prepupae new  (1236) white prepupae 12hr  (1228) white prepupae 24hr  (1474) pupae 2d postWPP  (1456) pupae 3d postWPP  (713) pupae 4d postWPP  (666) adult male 01day  (824) adult male 05day  (917) adult male 30day  (938) adult female 01day  (2115) adult female 05day  (3089) adult female 30day  (3357) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5989) embryo 02-04hr  (1935) embryo 04-06hr  1451 embryo 06-08hr  (2732) embryo 08-10hr  (2152) embryo 10-12hr  (2444) embryo 12-14hr  (1840) embryo 14-16hr  (2144) embryo 16-18hr    1021 embryo 18-20hr    943 embryo 20-22hr    834 embryo 22-24hr    664 larva L1    1011 larva L2    1231 larva L3 12hr old    977 larva L3 puffstage 1-2    714 larva L3 puffstage 3-6    1214 larva L3 puffstage 7-9    1033 white prepupae new    1236 white prepupae 12hr    1228 white prepupae 24hr  1474 pupae 2d postWPP  1456 pupae 3d postWPP    713 pupae 4d postWPP    666 adult male 01day    824 adult male 05day    917 adult male 30day    938 adult female 01day  (2115) adult female 05day  (3089) adult female 30day  (3357) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5989 embryo 02-04hr    1935 embryo 04-06hr    1451 embryo 06-08hr    2732 embryo 08-10hr    2152 embryo 10-12hr    2444 embryo 12-14hr    1840 embryo 14-16hr    2144 embryo 16-18hr    1021 embryo 18-20hr    943 embryo 20-22hr    834 embryo 22-24hr    664 larva L1    1011 larva L2    1231 larva L3 12hr old    977 larva L3 puffstage 1-2    714 larva L3 puffstage 3-6    1214 larva L3 puffstage 7-9    1033 white prepupae new    1236 white prepupae 12hr    1228 white prepupae 24hr    1474 pupae 2d postWPP    1456 pupae 3d postWPP    713 pupae 4d postWPP    666 adult male 01day    824 adult male 05day    917 adult male 30day    938 adult female 01day    2115 adult female 05day    3089 adult female 30day    3357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5989 embryo 02-04hr    1935 embryo 04-06hr    1451 embryo 06-08hr    2732 embryo 08-10hr    2152 embryo 10-12hr    2444 embryo 12-14hr    1840 embryo 14-16hr    2144 embryo 16-18hr    1021 embryo 18-20hr    943 embryo 20-22hr    834 embryo 22-24hr    664 larva L1    1011 larva L2    1231 larva L3 12hr old    977 larva L3 puffstage 1-2    714 larva L3 puffstage 3-6    1214 larva L3 puffstage 7-9    1033 white prepupae new    1236 white prepupae 12hr    1228 white prepupae 24hr    1474 pupae 2d postWPP    1456 pupae 3d postWPP    713 pupae 4d postWPP    666 adult male 01day    824 adult male 05day    917 adult male 30day    938 adult female 01day    2115 adult female 05day    3089 adult female 30day    3357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0045862 expression level Developmental Stage   Expression Level embryo 00-02hr    5989 embryo 02-04hr    1935 embryo 04-06hr    1451 embryo 06-08hr    2732 embryo 08-10hr    2152 embryo 10-12hr    2444 embryo 12-14hr    1840 embryo 14-16hr    2144 embryo 16-18hr    1021 embryo 18-20hr    943 embryo 20-22hr    834 embryo 22-24hr    664 larva L1    1011 larva L2    1231 larva L3 12hr old    977 larva L3 puffstage 1-2    714 larva L3 puffstage 3-6    1214 larva L3 puffstage 7-9    1033 white prepupae new    1236 white prepupae 12hr    1228 white prepupae 24hr    1474 pupae 2d postWPP    1456 pupae 3d postWPP    713 pupae 4d postWPP    666 adult male 01day    824 adult male 05day    917 adult male 30day    938 adult female 01day    2115 adult female 05day    3089 adult female 30day    3357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5989) embryo 02-04hr  (1935) embryo 04-06hr  (1451) embryo 06-08hr  (2732) embryo 08-10hr  (2152) embryo 10-12hr  (2444) embryo 12-14hr  (1840) embryo 14-16hr  (2144) embryo 16-18hr  (1021) embryo 18-20hr  (943) embryo 20-22hr  (834) embryo 22-24hr  (664) larva L1  (1011) larva L2  (1231) larva L3 12hr old  (977) larva L3 puffstage 1-2  (714) larva L3 puffstage 3-6  (1214) larva L3 puffstage 7-9  (1033) white prepupae new  (1236) white prepupae 12hr  (1228) white prepupae 24hr  (1474) pupae 2d postWPP  (1456) pupae 3d postWPP  (713) pupae 4d postWPP  (666) adult male 01day  (824) adult male 05day  (917) adult male 30day  (938) adult female 01day  (2115) adult female 05day  (3089) adult female 30day  (3357) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5989) embryo 02-04hr  1935 embryo 04-06hr  1451 embryo 06-08hr  (2732) embryo 08-10hr  2152 embryo 10-12hr  2444 embryo 12-14hr  1840 embryo 14-16hr  2144 embryo 16-18hr    1021 embryo 18-20hr    943 embryo 20-22hr    834 embryo 22-24hr    664 larva L1    1011 larva L2    1231 larva L3 12hr old    977 larva L3 puffstage 1-2    714 larva L3 puffstage 3-6    1214 larva L3 puffstage 7-9    1033 white prepupae new    1236 white prepupae 12hr    1228 white prepupae 24hr  1474 pupae 2d postWPP  1456 pupae 3d postWPP    713 pupae 4d postWPP    666 adult male 01day    824 adult male 05day    917 adult male 30day    938 adult female 01day  2115 adult female 05day  (3089) adult female 30day  (3357) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5989 embryo 02-04hr    1935 embryo 04-06hr    1451 embryo 06-08hr    2732 embryo 08-10hr    2152 embryo 10-12hr    2444 embryo 12-14hr    1840 embryo 14-16hr    2144 embryo 16-18hr    1021 embryo 18-20hr    943 embryo 20-22hr    834 embryo 22-24hr    664 larva L1    1011 larva L2    1231 larva L3 12hr old    977 larva L3 puffstage 1-2    714 larva L3 puffstage 3-6    1214 larva L3 puffstage 7-9    1033 white prepupae new    1236 white prepupae 12hr    1228 white prepupae 24hr    1474 pupae 2d postWPP    1456 pupae 3d postWPP    713 pupae 4d postWPP    666 adult male 01day    824 adult male 05day    917 adult male 30day    938 adult female 01day    2115 adult female 05day    3089 adult female 30day    3357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5989 embryo 02-04hr    1935 embryo 04-06hr    1451 embryo 06-08hr    2732 embryo 08-10hr    2152 embryo 10-12hr    2444 embryo 12-14hr    1840 embryo 14-16hr    2144 embryo 16-18hr    1021 embryo 18-20hr    943 embryo 20-22hr    834 embryo 22-24hr    664 larva L1    1011 larva L2    1231 larva L3 12hr old    977 larva L3 puffstage 1-2    714 larva L3 puffstage 3-6    1214 larva L3 puffstage 7-9    1033 white prepupae new    1236 white prepupae 12hr    1228 white prepupae 24hr    1474 pupae 2d postWPP    1456 pupae 3d postWPP    713 pupae 4d postWPP    666 adult male 01day    824 adult male 05day    917 adult male 30day    938 adult female 01day    2115 adult female 05day    3089 adult female 30day    3357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0045862    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0045862 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval/adult salivary gland, larval trachea, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0045862 expression level Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0045862 expression level Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    70.4   NA  Eye    103.75   NA  Brain    115.7   148.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    94   NA  Crop    96.6   70  Midgut    59.4   107.2  Hindgut    72   78.8  Malpighian Tubules    85.4   51.6  Fat Body    73   165.5  Salivary Gland    140   NA  Heart    61.375   110.1  Trachea    NA   NA  VirginFemale Spermatheca    97.6   NA  InseminatedFemale Spermatheca    95   NA  Ovary    226.6   NA  Testis    33.2   NA  Male Accessory Gland    99   100.25  Carcass    61.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045862 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12878-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 btzGD7855 Sterility Allele female sterile | cold sensitive btz1 female sterile | maternal effect | cold sensitive btz1 Other Phenotypes Allele visible btz1 visible, with Scer\GAL4pnr-MD237 btzGD7855 wild-type btz+t7.3 btzrL203 btzαTub67C.T:Avic\GFP Phenotype manifest in Allele abdomen btz1 denticle belt btz2 denticle belt (with Df(3R)IR16) btz2 embryonic/first instar larval cuticle btz2 embryonic/first instar larval cuticle (with Df(3R)IR16) btz2 embryonic abdominal segment | maternal effect btz1 mesothoracic tergum, with Scer\GAL4pnr-MD237 btzGD7855 microtubule & oocyte | oogenesis stage S9 | germ-line clone btz2 ovariole | maternal effect | cold sensitive btz1 ovary | cold sensitive btz1 pole cell btz2 pole cell (with Df(3R)IR16) btz2 pole cell | cold sensitive btz1 trichogen cell, with Scer\GAL4pnr-MD237 btzGD7855
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of btz Class Mutagen Stocks Known lesion btzrL203 P-element activity 1 Yes btz2 amorphic allele - genetic evidence Delta2-3 0 Yes btz1 loss of function allele 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of btz Class Mutagen Stocks Known lesion btzGD7855 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes btzHM05220 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes btzKK111083 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes btz+t7.3 in vitro construct - genomic fragment 0 Yes btztvEa in vitro construct - site directed mutagenesis 0 Yes btzαTub67C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)IR16 (van Eeden et al., 2001, Braat et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7855} NA P{KK111083} NA P{TRiP.HM05220} NA characterization construct P{btztvEa} NA P{CG12876tvEa} NA P{αTub67C-btz.T:Avic\GFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}btzrL203 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
translation initiation factor binding inferred from physical interaction with eIF4AIII (Palacios et al., 2004)
Biological Process
CV term Evidence References
NOT bicoid mRNA localization inferred from mutant phenotype (van Eeden et al., 2001) NOT oocyte microtubule cytoskeleton polarization inferred from mutant phenotype (van Eeden et al., 2001) oocyte microtubule cytoskeleton polarization inferred from mutant phenotype (Zimyanin et al., 2007) pole plasm oskar mRNA localization inferred from mutant phenotype (van Eeden et al., 2001) inferred from physical interaction with eIF4AIII (Palacios et al., 2004) pole plasm protein localization inferred from mutant phenotype (van Eeden et al., 2001) ribonucleoprotein complex assembly inferred from mutant phenotype (Trucco et al., 2009)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (van Eeden et al., 2001) nuclear envelope inferred from direct assay (van Eeden et al., 2001) ribonucleoprotein complex inferred from direct assay (Trucco et al., 2009)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
pole plasm oskar mRNA localization traceable author statement (Tekotte and Davis, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions btz allele Gene References btz1 eIF4AIII (Palacios et al., 2004) osk (Palacios et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68213 DroID - A comprehensive database of gene and protein interactions. • FBgn0045862 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43331
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16300 Dere\GG11571 Dgri\GH16542 Dmoj\GI22023 Dper\GL13710 Dpse\GA11878 Dsec\GM16353 Dsim\GD21349 Dvir\GJ10472 Dwil\GK11767 Dyak\GE23756
Curated drosophilid orthologs	Dpse\GA11878
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002823-PA Aedes aegypti (mosquito) AGAP011399-PA Anopheles gambiae (mosquito) XP_001952339.1 Acyrthosiphon pisum (pea aphid) 120980 Branchiostoma floridae (lancelet) 130679 Branchiostoma floridae (lancelet) BGIBMGA004423-PA Bombyx mori (silk worm) ENSBTAP00000008203 Bos taurus (bovine) CN20344 Caenorhabditis brenneri (small nematode) CBP25930 Caenorhabditis briggsae (nematode) CE26028 Caenorhabditis elegans (worm) ENSCAFP00000023784 Canis familiaris (dog) JA11240 Caenorhabditis japonica (nematode) CPIJ003232 Culex pipens (mosquito) ENSCPOP00000013648 Cavia porcellus (guinea pig) 226679 Capitella spl (polychaete worm) 263680 Daphnia pulex (daphnia) ENSDARP00000040064 Danio rerio (zebra fish) ENSECAP00000017628 Equus caballus (horse) ENSGACP00000019829 Gymnopilus aculeatus (mushroom) ENSGALP00000021960 Gallus gallus (chicken) ENSP00000264645 Homo sapiens (human) 237809 Lottia gigantea (owl limpet) ENSMODP00000016323 Monodelphis domestica (gray opossum) ENSMMUP00000029378 Macaca mulatta (rhesus monkey) ENSMUSP00000017384 Mus musculus (house mouse) XP_001604627.1 Nasonia vitripennis (wasp) ENSOANP00000005538 Ornithorynchus anatinus (platypus) PHUM008245-PA Pediculus humanus (human body louse) ENSPPYP00000009515 Pongo pygmaeus (orangutan) ENSPTRP00000015537 Pan troglodytes (chimpanzee) ENSRNOP00000013204 Rattus norvegicus (norway rat) Smp_128420 Schistosoma mansoni (trematode parasite) XP_975679.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005788 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000001608 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000052759 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11186 NV13425 LH17126 ISCW009123 FBgn0240913 FBgn0197752 FBgn0171268 JGI_V11_329548 JGI_V11_332554 FBgn0071927 FBgn0151315 FBgn0144752 FBgn0093322 CPIJ003232 CPIJ006438 CPIJ017976 BGIBMGA004422 ACYPI003992 GB17731 AGAP011399 AAEL002823 PHUM283350 GLEAN_10061
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	30482 y1 sc* v1; P{TRiP.HM05220}attP2/TM3, Sb1 10345 ry506 P{PZ}btzrL203/TM3, ryRK Sb1 Ser1
VDRC	v108761 P{KK111083}VIE-260B v38722 w1118; P{GD7855}v38722 v38721 w1118; P{GD7855}v38721/CyO
Genomic Clones ( 2 )
	BACR02M05 BACR10J03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT25787 LD31454 LD37788
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10925 AT26334 AT28729 GH06511 GH23317 LD13603 LD35459 LP11350 LP20638 LP22809 RE39591 RE44594 RE49644 RE61385 RH58212 SD02887 SD09185 SD16861
Other clones	18784 44062 51223 144797 164631 191079 277687 CK01.64D.B2 Dmel_neb_015435_0931_3092 EK065237 EK133449 EK158815 EK160146 EK163246 EK212518 EK250724 EK293649 LD44265 RP003024429 RP003065378 RP003088020 RP003104980 RP003113586 RP003134570 RP003159279 RP003178112 RP003216089 RP003251877 RP003291661 RP003315898 RP003380433 RP003664963 RP003666404
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0045862 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43331
Antibody Information
	polyclonal (van Eeden et al., 2001)
Other Information
Discoverer
Etymology
	Based on the phenotype where osk mRNA becomes trapped at the anterior and fails to reach the posterior pole, the gene is named after Willem Barentsz, a seventeenth century explorer whose boat became frozen in the ice off Novaya Zemlya during an attempt to find a passage past the North pole. (van Eeden et al., 2001)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: btz wkl (van Eeden et al., 2001)
Source for database merge of	Source for merge of: btz CG12878 (van Eeden et al., 2001)
Additional comments
Other Comments
	cup is specifically required to localise btz to the oocyte. (Wilhelm et al., 2003) Mutant allele(s) show poor localization of stau protein and osk mRNA in oocyte. (Weston and St, 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079810 NM_170350 RefSeq (Proteins) • NP_524534 NP_733229 DDBJ / EMBL / GenBank • AA439125 AAF56741 AAK93315 AAN14126 AI518311 AQ026368 AW943397 AY051891 Entrez Gene - A searchable database of RefSeq genes. • 43331 UniProtKB/TrEMBL • Q7KRX5 Q9VB04 Q960S3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CASC3/Barentsz eIF4AIII binding (IPR018545)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68213 DroID - A comprehensive database of gene and protein interactions. • FBgn0045862 DRSC - Results from RNAi screens. • FBgn0045862 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045862 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12878-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0045862 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43331 InParanoid A subset of ortholog calls from InParanoid. • AAEL002823-PA Aedes aegypti (mosquito) AGAP011399-PA Anopheles gambiae (mosquito) XP_001952339.1 Acyrthosiphon pisum (pea aphid) 120980 Branchiostoma floridae (lancelet) 130679 Branchiostoma floridae (lancelet) BGIBMGA004423-PA Bombyx mori (silk worm) ENSBTAP00000008203 Bos taurus (bovine) CN20344 Caenorhabditis brenneri (small nematode) CBP25930 Caenorhabditis briggsae (nematode) CE26028 Caenorhabditis elegans (worm) ENSCAFP00000023784 Canis familiaris (dog) JA11240 Caenorhabditis japonica (nematode) CPIJ003232 Culex pipens (mosquito) ENSCPOP00000013648 Cavia porcellus (guinea pig) 226679 Capitella spl (polychaete worm) 263680 Daphnia pulex (daphnia) ENSDARP00000040064 Danio rerio (zebra fish) ENSECAP00000017628 Equus caballus (horse) ENSGACP00000019829 Gymnopilus aculeatus (mushroom) ENSGALP00000021960 Gallus gallus (chicken) ENSP00000264645 Homo sapiens (human) 237809 Lottia gigantea (owl limpet) ENSMODP00000016323 Monodelphis domestica (gray opossum) ENSMMUP00000029378 Macaca mulatta (rhesus monkey) ENSMUSP00000017384 Mus musculus (house mouse) XP_001604627.1 Nasonia vitripennis (wasp) ENSOANP00000005538 Ornithorynchus anatinus (platypus) PHUM008245-PA Pediculus humanus (human body louse) ENSPPYP00000009515 Pongo pygmaeus (orangutan) ENSPTRP00000015537 Pan troglodytes (chimpanzee) ENSRNOP00000013204 Rattus norvegicus (norway rat) Smp_128420 Schistosoma mansoni (trematode parasite) XP_975679.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005788 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000001608 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000052759 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43331 modMine - Data generated by the modENCODE project. • FBgn0045862 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11186 NV13425 LH17126 ISCW009123 FBgn0240913 FBgn0197752 FBgn0171268 JGI_V11_329548 JGI_V11_332554 FBgn0071927 FBgn0151315 FBgn0144752 FBgn0093322 CPIJ003232 CPIJ006438 CPIJ017976 BGIBMGA004422 ACYPI003992 GB17731 AGAP011399 AAEL002823 PHUM283350 GLEAN_10061
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Btz (Wilhelm et al., 2003, Zimyanin et al., 2007, Zimyanin et al., 2007, Saulière et al., 2010) btz (Navarro et al., 2004, Irion et al., 2006, Zimyanin et al., 2008, Trucco et al., 2009, Snee et al., 2007, Roignant and Treisman, 2010, Ashton-Beaucage et al., 2010) CG12878 (Perkins et al., 2009, Wagstaff and Begun, 2005, Keleman et al., 2009.8.5) unnamed (Spradling et al., 1999, BDGP Project Members, 1994-1999) wkl (Staab et al., 1996, Weston and St, 1996, )
Name Synonym	barentsz (van Eeden et al., 2001, Zimyanin et al., 2008, Snee et al., 2007) Barentsz (Roignant et al., 2007, Trucco et al., 2009, Saulière et al., 2010) barentz (Navarro et al., 2004) weak localizer (Weston and St, 1996)
Secondary FlyBase IDs
	FBgn0016077 FBgn0039542
References ( 43 )
Generate a list of	All references relating to this gene ( 43 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 2 ) Review  ( 10 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 4 ) Computer file  ( 2 )
Recent research papers ( 3 )
	Ashton-Beaucage et al., 2010, Cell 143(2): 251--262 The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. [FBrf0212064] Roignant and Treisman, 2010, Cell 143(2): 238--250 Exon Junction Complex Subunits Are Required to Splice Drosophila MAP Kinase, a Large Heterochromatic Gene. [FBrf0212083] Saulière et al., 2010, Nat. Struct. Mol. Biol. 17(10): 1269--1271 The exon junction complex differentially marks spliced junctions. [FBrf0212018] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...