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Gene Dmel\btz

General Information
Symbol	Dmel\btz	Species	D. melanogaster
Name	barentsz	Annotation symbol	CG12878
Feature type	protein_coding_gene	FlyBase ID	FBgn0045862
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	wkl
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	98B1-98B2	Sequence location	3R:23,526,083..23,529,167 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene barentsz is referred to in FlyBase by the symbol Dmel\btz (CG12878, FBgn0045862). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: translation initiation factor binding. There is experimental evidence that it is involved in the biological process: pole plasm protein localization; pole plasm oskar mRNA localization; oocyte microtubule cytoskeleton polarization. 9 alleles are reported. The phenotypes of these alleles are annotated with: abdomen; embryonic/first instar larval cuticle; trichogen cell; pole cell; mesothoracic tergum; denticle belt. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Btz domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval/adult salivary gland, larval trachea, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637956_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of btz. Gene sequence location is 3R:23526083..23529167.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98B1-98B2   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98B1-98B2   (determined by in situ hybridisation)   (Spradling et al., 1999) 98B1-98B2     (BDGP Project Members, 1994-1999) 98A-98A   Determined by deficiency mapping (details unspecified).   (Weston and St, 1996)
Experimentally Determined Recombination Data
Location	3- (Weston and St, 1996)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\btz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 DGC clone appears problematic (LD37788): incomplete CDS. Gene model reviewed during 5.49 gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UGA) postulated; FBrf0216884.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) btz-RA FBtr0085220  NM_079810   2742   761 btz-RB FBtr0085221  NM_170350   3021   782 btz-RC FBtr0330084  NM_001276098   2671   761 btz-RD FBtr0330085  NM_001276099   3009   806
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein btz-PA   FBpp0084590   83.7   761   5.18     NP_524534   AAF56741 btz-PB   FBpp0084591   86.1   782   5.33     NP_733229   AAN14126 btz-PC   FBpp0303117   83.7   761   5.18     NP_001263027   AGB96407 btz-PD   FBpp0303118   88.6   806   5.67     NP_001263028   AGB96408
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Btz domain (IPR018545)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439125   AE014297 AAF56741   AE014297 AAN14126   AE014297 AGB96407   AE014297 AGB96408   AI107188   AI297127   AI403803   AI455776   AI512398   AI518311   AI542736   AI546541   AQ026368   AW943397   AY051891 AAK93315   BF490055   BF491812   BF496917   BI242300   BI357968   BI364509   BI373924   BI629361   BI635493   BT056272   BT099786   CK656941   CK661270   CO279065   CO281789   CO282292   CO287219   CO296015   CO306295   CO329749   DN154047   EC058240   EC066684   EC067364   EC077300   EC222428   EC234252   EC239797   EC244524   EV597198   GH758522   GH773556   GH773896   GH802313   GH806451   GH808363   GH814884   GH822937   GH827235   GH849236   GH866651   GH878220   GH904484   GH907878   GH911170
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KRX5 Q9VB04 Q960S3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage | female   germarium region 2   (van Eeden et al., 2001) adult stage | female & oogenesis   oocyte of germarium region 2b   (van Eeden et al., 2001) adult stage | femaleoogenesis stage S4 -- oogenesis stage S7   oocyte | posterior   (van Eeden et al., 2001) Comment:posterior enrichments begins to disperse at stage S6 adult stage | female & oogenesis stage S8   oocyte   • cytoplasm (van Eeden et al., 2001) adult stage | femaleoogenesis stage S4 -- oogenesis stage S9   nurse cell   • nuclear envelope | punctate (van Eeden et al., 2001) adult stage | female & oogenesis stage S9   oocyte | posterior   • cell cortex | posterior (van Eeden et al., 2001) ring canal | surrounding   (van Eeden et al., 2001) adult stage | female & oogenesis stage S10B   oocyte   • cytoplasm (van Eeden et al., 2001) Comment:transient posterior enrichment disperses during stage S10A western blot Stage Tissue/Position (including subcellular localization) Reference adult stage | female   ovary   (van Eeden et al., 2001) adult stage | femaleoogenesis stage S1 -- oogenesis stage S10   egg chamber   (van Eeden et al., 2001)
Additional Descriptive Data
	btz protein is first expressed in germarium region 2, then accumulates in oocytes in germarium region 2b. At oogenesis stage S4, btz is localized to the posterior of the oocyte, then begins to lose posterior enrichment at oogenesis stage S6. By oogenesis stage 8, btz protein has dispersed throughout the cytoplasm of the oocyte. At oogenesis stage S9, btz is again enriched at the posterior of the oocyte, then begins to disperse into the cytoplasm at the beginning of oogenesis stage S10; by oogenesis stage S10b btz is completely dispersed. From oogenesis stage S4, btz protein is also concentrated in a punctate pattern around the nuclei of nurse cells, with a similar distribution in follicle cells beginning at oogenesis stage S6; this pattern is suggestive of an association with the nuclear pores of these cells. btz protein colocalizes with mago in a dense cloud around the ring canals, and at the posterior pole of stage 9 oocytes. (van Eeden et al., 2001)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (van Eeden et al., 2001) colocalizes_with exon-exon junction complex inferred from direct assay (Guruharsha et al., 2011) nuclear envelope inferred from direct assay (van Eeden et al., 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval/adult salivary gland, larval trachea, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    148.65 Larval Midgut    70 Larval Hindgut    107.2 Larval Malpighian Tubules    78.8 Larval Fat Body    51.6 Larval Salivary Gland    165.5 Larval Trachea    110.1 Larval Carcass    100.25 Adult Head    70.4 Adult Eye    103.75 Adult Brain    115.7 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    96.6 Adult Midgut    59.4 Adult Hindgut    72 Adult Malpighian Tubules    85.4 Adult Fat Body    73 Adult Salivary Gland    140 Adult Heart    61.375 Adult VirginFemale Spermatheca    97.6 Adult InseminatedFemale Spermatheca    95 Adult Ovary    226.6 Adult Testis    33.2 Adult Male Accessory Gland    99 Adult Carcass    61.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    70.4   NA  Eye    103.75   NA  Brain    115.7   148.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    94   NA  Crop    96.6   70  Midgut    59.4   107.2  Hindgut    72   78.8  Malpighian Tubules    85.4   51.6  Fat Body    73   165.5  Salivary Gland    140   NA  Heart    61.375   110.1  Trachea    NA   NA  VirginFemale Spermatheca    97.6   NA  InseminatedFemale Spermatheca    95   NA  Ovary    226.6   NA  Testis    33.2   NA  Male Accessory Gland    99   100.25  Carcass    61.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    50 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    17 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    16 head, mated 20-day female    15 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    14 digestive system, 4-day adult    18 digestive system, 20-day adult    18 fat body, larvae L3 wandering    13 fat body, white prepupae    16 fat body, pupae P8    14 carcass, larvae L3 wandering    33 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    76 ovary, mated 4-day female    87 testis, mated 4-day male    13 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (37) central nervous system, larvae L3  (50) central nervous system, pupae P8  (27) head, virgin 1-day female    15 head, virgin 4-day female    17 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    16 head, mated 20-day female    15 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    14 digestive system, 4-day adult    18 digestive system, 20-day adult    18 fat body, larvae L3 wandering    13 fat body, white prepupae    16 fat body, pupae P8    14 carcass, larvae L3 wandering  (33) carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female  (76) ovary, mated 4-day female  (87) testis, mated 4-day male    13 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    50 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    17 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    16 head, mated 20-day female    15 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    14 digestive system, 4-day adult    18 digestive system, 20-day adult    18 fat body, larvae L3 wandering    13 fat body, white prepupae    16 fat body, pupae P8    14 carcass, larvae L3 wandering    33 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    76 ovary, mated 4-day female    87 testis, mated 4-day male    13 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    50 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    17 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    16 head, mated 20-day female    15 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    14 digestive system, 4-day adult    18 digestive system, 20-day adult    18 fat body, larvae L3 wandering    13 fat body, white prepupae    16 fat body, pupae P8    14 carcass, larvae L3 wandering    33 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    76 ovary, mated 4-day female    87 testis, mated 4-day male    13 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    50 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    17 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    16 head, mated 20-day female    15 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    14 digestive system, 4-day adult    18 digestive system, 20-day adult    18 fat body, larvae L3 wandering    13 fat body, white prepupae    16 fat body, pupae P8    14 carcass, larvae L3 wandering    33 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    76 ovary, mated 4-day female    87 testis, mated 4-day male    13 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (37) central nervous system, larvae L3  (50) central nervous system, pupae P8  27 head, virgin 1-day female    15 head, virgin 4-day female    17 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    16 head, mated 20-day female    15 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    14 digestive system, 4-day adult    18 digestive system, 20-day adult    18 fat body, larvae L3 wandering    13 fat body, white prepupae    16 fat body, pupae P8    14 carcass, larvae L3 wandering  (33) carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female  (76) ovary, mated 4-day female  (87) testis, mated 4-day male    13 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    50 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    17 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    16 head, mated 20-day female    15 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    14 digestive system, 4-day adult    18 digestive system, 20-day adult    18 fat body, larvae L3 wandering    13 fat body, white prepupae    16 fat body, pupae P8    14 carcass, larvae L3 wandering    33 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    76 ovary, mated 4-day female    87 testis, mated 4-day male    13 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    50 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    17 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    16 head, mated 20-day female    15 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    14 digestive system, 4-day adult    18 digestive system, 20-day adult    18 fat body, larvae L3 wandering    13 fat body, white prepupae    16 fat body, pupae P8    14 carcass, larvae L3 wandering    33 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    76 ovary, mated 4-day female    87 testis, mated 4-day male    13 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    26 embryo 04-06hr    20 embryo 06-08hr    37 embryo 08-10hr    29 embryo 10-12hr    33 embryo 12-14hr    25 embryo 14-16hr    29 embryo 16-18hr    14 embryo 18-20hr    13 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    14 larva L2    17 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    14 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (81) embryo 02-04hr  26 embryo 04-06hr    20 embryo 06-08hr  (37) embryo 08-10hr  (29) embryo 10-12hr  (33) embryo 12-14hr    25 embryo 14-16hr  (29) embryo 16-18hr    14 embryo 18-20hr    13 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    14 larva L2    17 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    14 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day  (29) adult female 05day  (42) adult female 30day  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    26 embryo 04-06hr    20 embryo 06-08hr    37 embryo 08-10hr    29 embryo 10-12hr    33 embryo 12-14hr    25 embryo 14-16hr    29 embryo 16-18hr    14 embryo 18-20hr    13 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    14 larva L2    17 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    14 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    26 embryo 04-06hr    20 embryo 06-08hr    37 embryo 08-10hr    29 embryo 10-12hr    33 embryo 12-14hr    25 embryo 14-16hr    29 embryo 16-18hr    14 embryo 18-20hr    13 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    14 larva L2    17 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    14 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    26 embryo 04-06hr    20 embryo 06-08hr    37 embryo 08-10hr    29 embryo 10-12hr    33 embryo 12-14hr    25 embryo 14-16hr    29 embryo 16-18hr    14 embryo 18-20hr    13 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    14 larva L2    17 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    14 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (81) embryo 02-04hr  26 embryo 04-06hr    20 embryo 06-08hr  (37) embryo 08-10hr  29 embryo 10-12hr  (33) embryo 12-14hr    25 embryo 14-16hr  29 embryo 16-18hr    14 embryo 18-20hr    13 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    14 larva L2    17 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    14 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day  29 adult female 05day  (42) adult female 30day  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    26 embryo 04-06hr    20 embryo 06-08hr    37 embryo 08-10hr    29 embryo 10-12hr    33 embryo 12-14hr    25 embryo 14-16hr    29 embryo 16-18hr    14 embryo 18-20hr    13 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    14 larva L2    17 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    14 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    26 embryo 04-06hr    20 embryo 06-08hr    37 embryo 08-10hr    29 embryo 10-12hr    33 embryo 12-14hr    25 embryo 14-16hr    29 embryo 16-18hr    14 embryo 18-20hr    13 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    14 larva L2    17 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    14 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    35 embryonic 1182-4H    26 embryonic GM2    16 embryonic Kc167    13 embryonic S1    47 embryonic S3    20 leg disc CME L1    44 wing disc CME-W2    18 wing disc ML-DmD8    16 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    52 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    20 ovary fGS/OSS    85 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (34) Schneider line 2 Sg4  (35) embryonic 1182-4H  26 embryonic GM2    16 embryonic Kc167    13 embryonic S1  (47) embryonic S3    20 leg disc CME L1  (44) wing disc CME-W2    18 wing disc ML-DmD8    16 wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (39) wing disc ML-DmD21  (52) wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11  (36) antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1  (32) CNS ML-DmBG1-c1  (40) CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    20 ovary fGS/OSS  (85) ovary OSC  (37) ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    35 embryonic 1182-4H    26 embryonic GM2    16 embryonic Kc167    13 embryonic S1    47 embryonic S3    20 leg disc CME L1    44 wing disc CME-W2    18 wing disc ML-DmD8    16 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    52 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    20 ovary fGS/OSS    85 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    35 embryonic 1182-4H    26 embryonic GM2    16 embryonic Kc167    13 embryonic S1    47 embryonic S3    20 leg disc CME L1    44 wing disc CME-W2    18 wing disc ML-DmD8    16 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    52 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    20 ovary fGS/OSS    85 ovary OSC    37 ovary OSS    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    35 embryonic 1182-4H    26 embryonic GM2    16 embryonic Kc167    13 embryonic S1    47 embryonic S3    20 leg disc CME L1    44 wing disc CME-W2    18 wing disc ML-DmD8    16 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    52 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    20 ovary fGS/OSS    85 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (34) Schneider line 2 Sg4  (35) embryonic 1182-4H  26 embryonic GM2    16 embryonic Kc167    13 embryonic S1  (47) embryonic S3    20 leg disc CME L1  (44) wing disc CME-W2    18 wing disc ML-DmD8    16 wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (39) wing disc ML-DmD21  (52) wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11  (36) antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1  32 CNS ML-DmBG1-c1  (40) CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    20 ovary fGS/OSS  (85) ovary OSC  (37) ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    35 embryonic 1182-4H    26 embryonic GM2    16 embryonic Kc167    13 embryonic S1    47 embryonic S3    20 leg disc CME L1    44 wing disc CME-W2    18 wing disc ML-DmD8    16 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    52 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    20 ovary fGS/OSS    85 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    35 embryonic 1182-4H    26 embryonic GM2    16 embryonic Kc167    13 embryonic S1    47 embryonic S3    20 leg disc CME L1    44 wing disc CME-W2    18 wing disc ML-DmD8    16 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    52 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    20 ovary fGS/OSS    85 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    60 cold shock, 4-day adult    37 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    76 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    44 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (60) cold shock, 4-day adult  (37) heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult  (31) Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult  (31) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (76) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (61) Caffeine 25 mg/ml 48 hrs, 4-day adult  (44) Paraquat 5 mM 48 hrs, 4-day adult  (50) Paraquat 10 mM 48 hrs, 4-day adult  (56) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    60 cold shock, 4-day adult    37 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    76 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    44 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    60 cold shock, 4-day adult    37 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    76 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    44 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    60 cold shock, 4-day adult    37 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    76 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    44 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (60) cold shock, 4-day adult  (37) heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult  31 Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult  31 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (76) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (61) Caffeine 25 mg/ml 48 hrs, 4-day adult  (44) Paraquat 5 mM 48 hrs, 4-day adult  (50) Paraquat 10 mM 48 hrs, 4-day adult  (56) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    60 cold shock, 4-day adult    37 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    76 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    44 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    60 cold shock, 4-day adult    37 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    76 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    44 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045862 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12878-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 btzGD7855 Sterility Allele female sterile | cold sensitive btz1 female sterile | maternal effect | cold sensitive btz1 Other Phenotypes Allele visible btz1 visible, with Scer\GAL4pnr-MD237 btzGD7855 wild-type btz+t7.3 btzrL203 btzαTub67C.T:Avic\GFP Phenotype manifest in Allele abdomen btz1 denticle belt btz2 denticle belt (with Df(3R)IR16) btz2 embryonic/first instar larval cuticle btz2 embryonic/first instar larval cuticle (with Df(3R)IR16) btz2 embryonic abdominal segment | maternal effect btz1 mesothoracic tergum, with Scer\GAL4pnr-MD237 btzGD7855 microtubule & oocyte | oogenesis stage S9 | germ-line clone btz2 ovariole | maternal effect | cold sensitive btz1 ovary | cold sensitive btz1 pole cell btz2 pole cell (with Df(3R)IR16) btz2 pole cell | cold sensitive btz1 trichogen cell, with Scer\GAL4pnr-MD237 btzGD7855
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of btz Class Mutagen Stocks Known lesion btzrL203 P-element activity 1 Yes btz2 amorphic allele - genetic evidence Delta2-3 0 Yes btz1 cold sensitive loss of function allele 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of btz Class Mutagen Stocks Known lesion btzGD7855 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes btzHM05220 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes btzKK111083 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes btz+t7.3 in vitro construct - genomic fragment 0 Yes btztvEa in vitro construct - site directed mutagenesis 0 Yes btzαTub67C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)IR16 (van Eeden et al., 2001, Braat et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7855} NA P{KK111083} NA P{TRiP.HM05220} NA characterization construct P{btztvEa} NA P{CG12876tvEa} NA P{αTub67C-btz.T:Avic\GFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}btzrL203 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
translation initiation factor binding inferred from physical interaction with eIF4AIII (Palacios et al., 2004)
Biological Process
CV term Evidence References
NOT bicoid mRNA localization inferred from mutant phenotype (van Eeden et al., 2001) NOT oocyte microtubule cytoskeleton polarization inferred from mutant phenotype (van Eeden et al., 2001) oocyte microtubule cytoskeleton polarization inferred from mutant phenotype (Zimyanin et al., 2007) pole plasm oskar mRNA localization inferred from mutant phenotype (van Eeden et al., 2001) inferred from physical interaction with eIF4AIII (Palacios et al., 2004) pole plasm protein localization inferred from mutant phenotype (van Eeden et al., 2001)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (van Eeden et al., 2001) colocalizes_with exon-exon junction complex inferred from direct assay (Guruharsha et al., 2011) nuclear envelope inferred from direct assay (van Eeden et al., 2001)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
pole plasm oskar mRNA localization traceable author statement (Tekotte and Davis, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
btz - CG10103 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG10681 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG10889 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG10960 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG11070 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG11594 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG12279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG1271 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG14356 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG14786 experimental knowledge based (Guruharsha et al., 2011) btz - CG1486 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG1965 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG2921 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG31776 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG3838 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG4089 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG43164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG4612 experimental knowledge based (Guruharsha et al., 2011) btz - CG4622 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG4908 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG5274 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG6123 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG6701 experimental knowledge based (Guruharsha et al., 2011) btz - CG7102 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG7146 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG7686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG7730 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG7888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG7920 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG8021 experimental knowledge based (Guruharsha et al., 2011) btz - CG8173 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG8336 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG8735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CG8965 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Cdc27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - CycG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - E(spl)m7-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - E(spl)mδ-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - E(z) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - EfSec anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - EndoG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Gad1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - HDAC6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Hex-A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - IntS10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Mkk4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Moca-cyp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - ND75 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Obp44a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Ocrl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Pi4KIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Pitslre anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Pka-C1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Pka-R1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Prosβ2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Rab10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Rala anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Ras85D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Rcc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Rcd5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Rho1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - SNF4Aγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Su(H) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Syp experimental knowledge based (Guruharsha et al., 2011) btz - Tace anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - Vps25 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - YL-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - bsf experimental knowledge based (Guruharsha et al., 2011) btz - crn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - ct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - elB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - eya anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - gro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - l(2)35Bd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - lat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - lolal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - nct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - nito experimental knowledge based (Guruharsha et al., 2011) btz - qkr58E-3 experimental knowledge based (Guruharsha et al., 2011) btz - ric8a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - rumi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - sc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - scat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - sgg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - skpA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) btz - thoc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions btz allele Gene References btz1 eIF4AIII (Palacios et al., 2004) osk (Palacios et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68213 DroID - A comprehensive database of gene and protein interactions. • FBgn0045862 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43331
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NP7PN Dipteran inclusive ortholog search EOG6XKVGS Insect inclusive ortholog search EOG6GMSST Arthropod inclusive ortholog search EOG64XGZK Metazoa inclusive ortholog search EOG683RZ6
Orthologs in Drosophila Species (EOG6NP7PN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\btz     Drosophila sechellia   Dsec\GM16353 Y   Drosophila yakuba   Dyak\GE23756 Y   Drosophila ananassae   Dana\GF16300 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11878 Y   Drosophila persimilis   Dper\GL13710 Y   Drosophila virilis   Dvir\GJ10472 Y   Drosophila mojavensis   Dmoj\GI22023 Y
Orthologs in non-Drosophila Dipterans (EOG6XKVGS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002823   Anopheles gambiae Malaria mosquito  Agam\AGAP011399   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003232   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801464
Orthologs in non-Dipteran Insects (EOG6GMSST)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC100578879   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007449   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18249   Atta cephalotes Leafcutter ant  Acep\ACEP19484   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16561   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16283   Linepithema humile Argentine ant  Lhum\LH17126   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11186   Solenopsis invicta Red fire ant  Sinv\SINV14736   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003992   Bombyx mori Silkmoth  Bmor\BGIBMGA004422   Pediculus humanus Human body louse  Phum\PHUM283350   Tribolium castaneum Red flour beetle  Tcas\btz
Orthologs in non-Insect Arthropods (EOG64XGZK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_329548   Daphnia pulex Water flea  Dpux\JGI_V11_332554   Daphnia pulex Water flea  Dpux\matK   Ixodes scapularis Deer tick  Isca\ISCW009123
Orthologs in non-Arthropod Metazoa (EOG683RZ6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\W08E3.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011908gn   Danio rerio Zebrafish  Drer\casc3   Xenopus tropicalis Western clawed frog  Xtro\casc3   Gallus gallus Domestic chicken  Ggal\ENSGALG00000013508   Mus musculus House mouse  Mmus\Casc3   Rattus norvegicus Norway rat  Rnor\Casc3   Homo sapiens Human  Hsap\CASC3
Human Orthologs (1)
Gene OMIM HGNC Hsap\CASC3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21349 Drosophila sechellia Dsec\GM16353 Drosophila erecta Dere\GG11571 Drosophila yakuba Dyak\GE23756 Drosophila ananassae Dana\GF16300 Drosophila pseudoobscura pseudoobscura Dpse\GA11878 Drosophila persimilis Dper\GL13710 Drosophila willistoni Dwil\GK11767 Drosophila virilis Dvir\GJ10472 Drosophila mojavensis Dmoj\GI22023 Drosophila grimshawi Dgri\GH16542
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	30482 y1 sc* v1; P{TRiP.HM05220}attP2/TM3, Sb1 10345 ry506 P{PZ}btzrL203/TM3, ryRK Sb1 Ser1
VDRC	v108761 P{KK111083}VIE-260B v38722 w1118; P{GD7855}v38722 v38721 w1118; P{GD7855}v38721/CyO
Genomic Clones ( 2 )
	BACR02M05 BACR10J03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT25787 LD31454 LD37788
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10925 AT26334 AT28729 GH06511 GH23317 LD13603 LD35459 LP11350 LP20638 LP22809 RE39591 RE44594 RE49644 RE61385 RH58212 SD02887 SD09185 SD16861
Other clones	18784 44062 51223 144797 164631 191079 277687 CK01.64D.B2 Dmel_neb_015435_0931_3092 EK065237 EK133449 EK158815 EK160146 EK163246 EK212518 EK250724 EK293649 LD44265 RP003024429 RP003065378 RP003088020 RP003104980 RP003113586 RP003134570 RP003159279 RP003178112 RP003216089 RP003251877 RP003291661 RP003315898 RP003380433 RP003664963 RP003666404
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0045862 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43331
Antibody Information
	polyclonal (van Eeden et al., 2001)
Other Information
Discoverer
Etymology
	Based on the phenotype where osk mRNA becomes trapped at the anterior and fails to reach the posterior pole, the gene is named after Willem Barentsz, a seventeenth century explorer whose boat became frozen in the ice off Novaya Zemlya during an attempt to find a passage past the North pole. (van Eeden et al., 2001)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: btz wkl (van Eeden et al., 2001)
Source for database merge of	Source for merge of: btz CG12878 (van Eeden et al., 2001)
Additional comments
Other Comments
	cup is specifically required to localise btz to the oocyte. (Wilhelm et al., 2003) Mutant allele(s) show poor localization of stau protein and osk mRNA in oocyte. (Weston and St, 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079810 NM_170350 NM_001276098 NM_001276099 RefSeq (Proteins) • NP_524534 NP_733229 NP_001263027 NP_001263028 DDBJ / EMBL / GenBank • AA439125 AAF56741 AAK93315 AAN14126 AGB96407 AGB96408 AI518311 AQ026368 AW943397 AY051891 Entrez Gene - A searchable database of RefSeq genes. • 43331 UniProtKB/TrEMBL • Q7KRX5 Q9VB04 Q960S3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Btz domain (IPR018545)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68213 DroID - A comprehensive database of gene and protein interactions. • FBgn0045862 DRSC - Results from RNAi screens. • FBgn0045862 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0045862 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12878-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0045862 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43331 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43331 modMine - Data generated by the modENCODE project. • FBgn0045862
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Btz (Wilhelm et al., 2003, Zimyanin et al., 2007, Zimyanin et al., 2007, Saulière et al., 2010) btz (Navarro et al., 2004, Irion et al., 2006, Fan et al., 2011, Jungreis et al., 2011, Zimyanin et al., 2008, Snee et al., 2007, Roignant and Treisman, 2010, Ashton-Beaucage et al., 2010, Guruharsha et al., 2011) CG12878 (Perkins et al., 2009, Wagstaff and Begun, 2005, Keleman et al., 2009.8.5) unnamed (Spradling et al., 1999, BDGP Project Members, 1994-1999) wkl (Staab et al., 1996, Weston and St, 1996, )
Name Synonym	barentsz (van Eeden et al., 2001, Zimyanin et al., 2008, Snee et al., 2007) Barentsz (Roignant et al., 2007, Saulière et al., 2010, Ghosh et al., 2012) barentz (Navarro et al., 2004) Dm SELOR (Ghosh et al., 2012) weak localizer (Weston and St, 1996)
Secondary FlyBase IDs
	FBgn0016077 FBgn0039542
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 4 ) Review  ( 10 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 4 )
Recent research papers ( 3 )
	Ghosh et al., 2012, Nat. Struct. Mol. Biol. 19(4): 441--449 Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA. [FBrf0217905] Fan et al., 2011, PLoS ONE 6(5): e20612 Drosophila Ge-1 Promotes P Body Formation and oskar mRNA Localization. [FBrf0213914] Guruharsha et al., 2011, Cell 147(3): 690--703 A Protein Complex Network of Drosophila melanogaster. [FBrf0216491] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...