FlyBase Gene Report: Dmel\GluRIIC

General Information

Symbol

Dmel\GluRIIC

Species

D. melanogaster

Name

Glutamate receptor IIC

Annotation Symbol

CG4226

Feature Type

protein_coding_gene

FlyBase ID

FBgn0046113

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

GluRIII, DGluRIII, DGluRIIC, glutamate receptor III, GluRII-C

Key Links

Genomic Location

Cytogenetic map

21E2-21E2

Sequence location

2L:914,086..917,805 [+]

Recombination map

2-1.5

RefSeq locus

NT_033779 REGION:914086..917805

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (19 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables glutamate-gated calcium ion channel activity

inferred from direct assay

(Han et al., 2015)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

enables glutamate receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

non-traceable author statement

(Saitoe et al., 2001)

enables ionotropic glutamate receptor activity

inferred by curator from GO:0008328

(Qin et al., 2005)

enables kainate selective glutamate receptor activity

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000)

enables ligand-gated ion channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

enables signaling receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in calcium ion transport

inferred from direct assay

(Han et al., 2015)

involved_in chemical synaptic transmission

inferred from mutant phenotype

(Marrus et al., 2004)

involved_in establishment of protein localization

inferred from mutant phenotype

(Marrus et al., 2004)

involved_in neuromuscular synaptic transmission

inferred from expression pattern

(Qin et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in modulation of chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in synaptic transmission, glutamatergic

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred by curator from GO:0007274,GO:0008328

(Qin et al., 2005)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

part_of ionotropic glutamate receptor complex

inferred from mutant phenotype

(Qin et al., 2005)

located_in muscle cell postsynaptic specialization

inferred from direct assay

(Qin et al., 2005)

located_in neuromuscular junction

inferred from direct assay

(Karr et al., 2009)

located_in synapse

inferred from direct assay

(Marrus et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in postsynaptic membrane

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS - GLURII NEUROMUSCULAR JUNCTION-SUBTYPE

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS - GLURII NEUROMUSCULAR JUNCTION-SUBTYPE -: In Drosophila, neuromuscular junction type A and type B glutamate receptors are heterotetramers assembled from either GluRIIA or GluRIIB plus other GluRII subunits. In response to the neurotransmitter, glutamate, they conduct Ca2⁺. (Adapted from FBrf0228432).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\GluRIIC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPV3)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

GluRIIC-RD

FBtr0336969

NM_134713

3004

940

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

GluRIIC-PD

FBpp0307912

106.8

940

5.71

NP_608557

AAF51433

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

Antibody raised to C-terminal peptide -QGSGSSSGSNNAGRGEKEARV

(Marrus et al., 2004)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GluRIIC using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

GluRIIC_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval visceral muscle cell

(Fisher et al., 2012)

embryonic stage 16 -- 17

somatic muscle cell

(Marrus et al., 2004)

Additional Descriptive Data

Embryonic expression of GluRIIC transcript is observed in the somatic musculature excluded from the CNS.

(Marrus et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

somatic muscle cell

• postsynaptic density

(Qin et al., 2005)

third instar larval stage

embryonic/larval neuromuscular junction

• postsynaptic density

Comment: of all the muscles and from both type Ib and Is motoneurons.

(Marrus and DiAntonio, 2004)

somatic muscle cell

• neuromuscular junction

(Marrus et al., 2004)

somatic muscle cell

• type I terminal bouton

(Marrus et al., 2004)

somatic muscle cell

• type Is terminal bouton

(Marrus et al., 2004)

somatic muscle cell

• type Ib terminal bouton

(Marrus et al., 2004)

somatic muscle cell

• type II terminal bouton

(Marrus et al., 2004)

synapse | restricted

Comment: Postsynaptic.

(Graf et al., 2009)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism

(Qin et al., 2005)

Additional Descriptive Data

GluRIIC has punctate expression that fails to colocalize with Fas2 at the larval neuromuscular junction. Immunolocalization is observed postsynaptically at type Ib, Is and type II synaptic terminal buttons.

(Marrus et al., 2004)

Marker for

embryonic/larval neuromuscular junction

(Mosca and Schwarz, 2010)

Subcellular Localization

CV Term

Evidence

References

part_of ionotropic glutamate receptor complex

inferred from mutant phenotype

(Qin et al., 2005)

located_in muscle cell postsynaptic specialization

inferred from direct assay

(Qin et al., 2005)

located_in neuromuscular junction

inferred from direct assay

(Karr et al., 2009)

located_in synapse

inferred from direct assay

(Marrus et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\GluRIIC in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\GluRIIC

View exonic expression by tissue for Dmel\GluRIIC

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0046113

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33275/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0046113

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046113

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0046113

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4226

Flygut - An atlas of the Drosophila adult midgut

FBgn0046113

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\GluRIIC

Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of GluRIIC

Transgenic constructs containing regulatory region of GluRIIC

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)ast4

(Marrus et al., 2004)

Df(2L)Exel6003

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

GluRIIC^KK107050

lethal - all die during embryonic stage

lethal - all die during embryonic stage (with GluRIIC¹)

GluRIIC²

lethal - all die during embryonic stage (with GluRIIC²)

GluRIIC¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

GluRIIC^GD796

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

GluRIIC^GD796

viable, with Scer\GAL4^Mef2.PR

GluRIIC^GD796

Other Phenotypes

Allele

abnormal neuroanatomy, with Df(2L)ast1/GluRIIC², Scer\GAL4^G14

GluRIIC^UAS.cMa

abnormal neuroanatomy, with Scer\GAL4^G14

GluRIIC^JF01854

abnormal neuroanatomy (with Df(2L)ast1), with GluRIIC^UAS.cMa, Scer\GAL4^G14

GluRIIC²

abnormal neurophysiology, with Df(2L)ast1/GluRIIC², Scer\GAL4^- :

GluRIIC^UAS.cMa

abnormal neurophysiology, with GluRIIC¹/Df(2L)ast1, Scer\GAL4^- :

GluRIIC^UAS.cMa

abnormal neurophysiology, with Scer\GAL4^C57

GluRIIC^{dsRNA.UAS.cBa}

abnormal neurophysiology, with Scer\GAL4^C57, Scer\GAL4^elav-C155, Scer\GAL4^sca.PC

GluRIIC^{dsRNA.UAS.cBa}

abnormal neurophysiology (with Df(2L)ast1), with GluRIIC^UAS.cMa, Scer\GAL4^- :

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^C57, Scer\GAL4^elav-C155, Scer\GAL4^sca.PC

GluRIIC^{dsRNA.UAS.cBa}

paralytic | embryonic stage

some die during embryonic stage

some die during embryonic stage (with GluRIIC¹)

GluRIIC²

some die during embryonic stage (with GluRIIC²)

GluRIIC¹

Phenotype manifest in

Allele

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^C57, Scer\GAL4^elav-C155, Scer\GAL4^sca.PC

GluRIIC^{dsRNA.UAS.cBa}

neuromuscular junction | larval stage, with Df(2L)ast1/GluRIIC², Scer\GAL4^- :

GluRIIC^UAS.cMa

neuromuscular junction | larval stage, with GluRIIC¹/Df(2L)ast1, Scer\GAL4^- :

GluRIIC^UAS.cMa

neuromuscular junction | larval stage (with Df(2L)ast1), with GluRIIC^UAS.cMa, Scer\GAL4^- :

terminal bouton, with Df(2L)ast1/GluRIIC², Scer\GAL4^G14

GluRIIC^UAS.cMa

terminal bouton, with Scer\GAL4^G14

GluRIIC^JF01854

terminal bouton (with Df(2L)ast1), with GluRIIC^UAS.cMa, Scer\GAL4^G14

GluRIIC²

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\GRID2

4 of 15

Yes

Hsap\GRIK1

4 of 15

Yes

Hsap\GRIK2

4 of 15

Yes

Hsap\GRIK3

4 of 15

Yes

Hsap\GRIK4

4 of 15

Yes

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Hsap\ENPP2

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Grik1

4 of 15

Yes

Mmus\Grik2

4 of 15

Yes

Mmus\Grik4

4 of 15

Yes

Mmus\Grik5

4 of 15

Yes

Mmus\Grid1

3 of 15

Mmus\Grid2

3 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Rattus norvegicus (Norway rat) (17)

Rnor\Grik2

4 of 13

Yes

Rnor\Grik3

4 of 13

Yes

Rnor\Grik4

4 of 13

Yes

Rnor\Grik5

4 of 13

Yes

Rnor\Grid2

3 of 13

Yes

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Rnor\Grin3b

2 of 13

Yes

Rnor\Gria1

1 of 13

Rnor\Gria2

1 of 13

Rnor\Grid1

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (15)

Xtro\grik1

4 of 12

Yes

Xtro\grid1

3 of 12

Yes

Xtro\grid2

3 of 12

Yes

Xtro\grik4

3 of 12

Xtro\grik5-like.1

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\grik2

1 of 12

Xtro\grik3

1 of 12

Xtro\grik5

1 of 12

Yes

Danio rerio (Zebrafish) (32)

Drer\grik1a

4 of 15

Yes

Drer\grik1b

4 of 15

Yes

Drer\grik4

4 of 15

Yes

Drer\LOC100334689

4 of 15

Yes

Drer\grid1a

3 of 15

Yes

Drer\grid1b

3 of 15

Yes

Drer\grid2

3 of 15

Yes

Drer\grik2

3 of 15

Drer\grik5

3 of 15

Drer\LOC100331381

3 of 15

Drer\si:ch211-251b21.1

3 of 15

Yes

Drer\si:dkey-183j2.10

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\grin3ba

2 of 15

Yes

Drer\LOC100149482

2 of 15

Drer\gria4a

1 of 15

Drer\grin3bb

1 of 15

Yes

Drer\LOC100537813

1 of 15

Drer\LOC110438919

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\glr-5

4 of 15

Yes

Cele\glr-6

4 of 15

Yes

Cele\glr-3

3 of 15

Cele\glr-4

3 of 15

Cele\glr-8

3 of 15

Yes

Cele\C08B6.5

1 of 15

Cele\F59E12.8

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\T25E4.2

1 of 15

Yes

Cele\W02A2.5

1 of 15

Cele\ZK867.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (20)

Atha\ATGLR1.2

2 of 9

Yes

Atha\GLR1.1

2 of 9

Yes

Atha\GLR1.3

2 of 9

Yes

Atha\GLR1.4

2 of 9

Yes

Atha\GLR2.1

2 of 9

Yes

Atha\GLR2.2

2 of 9

Yes

Atha\GLR2.3

2 of 9

Yes

Atha\GLR2.4

2 of 9

Yes

Atha\GLR2.5

2 of 9

Yes

Atha\GLR2.6

2 of 9

Yes

Atha\GLR2.7

2 of 9

Yes

Atha\GLR2.8

2 of 9

Yes

Atha\GLR2.9

2 of 9

Yes

Atha\GLR2

2 of 9

Yes

Atha\GLR3.3

2 of 9

Yes

Atha\GLR3.4

2 of 9

Yes

Atha\GLR3.5

2 of 9

Yes

Atha\GLR3.6

2 of 9

Yes

Atha\GLR5

2 of 9

Yes

Atha\GLUR2

2 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (43)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

5 of 10

5 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

GRIK2; glutamate ionotropic receptor kainate type subunit 2

model of autosomal recessive non-syndromic intellectual disability

IEA

(FlyBase, 2019-)

GRID2; glutamate ionotropic receptor delta type subunit 2

model of autosomal recessive spinocerebellar ataxia 18

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GRID2; glutamate ionotropic receptor delta type subunit 2

4 of 15

602368

SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 18; SCAR18

autosomal recessive spinocerebellar ataxia 18

GRIK1; glutamate ionotropic receptor kainate type subunit 1

4 of 15

138245

GRIK2; glutamate ionotropic receptor kainate type subunit 2

4 of 15

138244

autosomal recessive non-syndromic intellectual disability

GRIK3; glutamate ionotropic receptor kainate type subunit 3

4 of 15

138243

GRIK4; glutamate ionotropic receptor kainate type subunit 4

4 of 15

600282

GRID1; glutamate ionotropic receptor delta type subunit 1

3 of 15

610659

GRIK5; glutamate ionotropic receptor kainate type subunit 5

3 of 15

600283

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

GluRIIC - Neto

anti tag coimmunoprecipitation, western blot

(Kim et al., 2015)

GluRIIC - cora

two hybrid

(Chen et al., 2005)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cac

enhanceable

GluRIIC

(Brusich et al., 2015)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0046113

MIST (protein-protein) - An integrated Molecular Interaction Database

GluRIIC

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0046113

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-1.5

Cytogenetic map

21E2-21E2

Sequence location

2L:914,086..917,805 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21E2-21E2

Limits computationally determined from genome sequence between P{lacW}l(2)k09610^k09610&P{lacW}S^k09538a and P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-1.5

(FlyBase, 2016)

2-1.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

84395

TI{2A-lexA::p65}GluRIIC^2A-lexA

25836

y¹ v¹; P{TRiP.JF01854}attP2

83268

y¹ w^*; TI{CRIMIC.TG4.1}GluRIIC^{CR01324-TG4.1}/SM6a

VDRC

v101180

P{KK107050}VIE-260B

v51438

w¹¹¹⁸ P{GD796}v51438

v318027

PBac{fTRG00096.sfGFP-TVPTBF}VK00033

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (13)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0046113

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0046113

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33275

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kim et al., 2021, Ramos et al., 2015, Sulkowski et al., 2014, Kern et al., 2013, Natarajan et al., 2013, Qin et al., 2005, Marrus and DiAntonio, 2004, Marrus et al., 2004)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: GluRIII CG4226

(Marrus et al., 2004)

Source for database merge of

Source for merge of: GluRIIC GluRIII

(Qin et al., 2005)

Additional comments

Other Comments

GluRIIC is required for synaptic localisation of GluRIIA and GluRIIB proteins. Either GluRIIA or GluRIIB, but not both, is required for synaptic localisation of GluRIIC protein. GluRIIA and GluRIIB proteins compete with each other for access to GluRIIC protein and subsequent localisation to the synapse.

(Marrus et al., 2004)

GluRIIC is required for synaptic transmission at the neuromuscular junction.

(Marrus et al., 2004)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33275

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPV3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPV3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0046113

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0046113

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33275/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0046113

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

GluRIIC_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046113

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0046113

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4226

Flygut - An atlas of the Drosophila adult midgut

FBgn0046113

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0046113

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33275

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4226

MARRVEL_MODEL - MARRVEL (model organism gene)

33275

modMine - A data warehouse for the modENCODE project

FBgn0046113

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0046113

DRSC - Results frm RNAi screens

FBgn0046113

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0046113

FlyMine - An integrated database for Drosophila genomics

FBgn0046113

MIST (protein-protein) - An integrated Molecular Interaction Database

GluRIIC

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

CG4226

(Kondo et al., 2020, Hu et al., 2015, Tsubouchi et al., 2012, Croset et al., 2010, Benton et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Gonzalez et al., 2004, Marrus et al., 2004)

CT13021

(Littleton and Ganetzky, 2000)

DGluR-IIC

(Saitoe et al., 2001)

DGluRIIC

(Lee and Wu, 2010, Lee et al., 2008, Saitoe et al., 2001)

DGluRIII

(Bae et al., 2016, Chen et al., 2015, Blunk et al., 2014, Bulat et al., 2014, Roy and Jackson, 2014, Enneking et al., 2013, Natarajan et al., 2013, Graf et al., 2012, Mosca et al., 2012, Graf et al., 2011, Kim et al., 2010, Graf et al., 2009, Viquez et al., 2009, Wairkar et al., 2008, Dickman, 2006, Dickman et al., 2006, Marrus and Diantonio, 2005, Griffith, 2004, Marrus and DiAntonio, 2004)

DmelGluRIIC

(Croset et al., 2010)

GLURIIC

(Jepson et al., 2014, Schwenkert et al., 2008)

GLURIII

(Quiñones-Frías and Littleton, 2021)

GluR

(Poovathumkadavil and Jagla, 2020, Heckscher et al., 2007)

GluR3

(Graham et al., 2010)

GluRC

(Estes et al., 2013)

GluRII-C

(Frank et al., 2009, Pielage et al., 2006)

GluRIIC

(Goel and Dickman, 2021, Kim et al., 2021, Scaplen and Petruccelli, 2021, Zeng et al., 2021, Chou et al., 2020, Han et al., 2020, Kondo et al., 2020, Zhao et al., 2020, Patrón et al., 2019, Rao and Deng, 2019.10.23, Gene Disruption Project members, 2018-, Bulgakova et al., 2017, Wang et al., 2017, Sarov et al., 2016, Sturgeon et al., 2016, Ziegler et al., 2016, Hu et al., 2015, Kim et al., 2015, Koles et al., 2015, Ramos et al., 2015, Gardiol and St Johnston, 2014, Ghosh et al., 2014, Machamer et al., 2014, Peled et al., 2014, Sulkowski et al., 2014, Castellanos et al., 2013, Estes et al., 2013, Lee et al., 2013, Nahm et al., 2013, Rohrbough et al., 2013, Bruckner et al., 2012, Chen and Ganetzky, 2012, Japanese National Institute of Genetics, 2012.5.21, Jordán-Álvarez et al., 2012, Kim et al., 2012, Rushton et al., 2012, Tsubouchi et al., 2012, Cheng et al., 2011, Ganesan et al., 2011, Banovic et al., 2010, Chen et al., 2010, Croset et al., 2010, Higashi-Kovtun et al., 2010, Mosca and Schwarz, 2010, Nahm et al., 2010, Rohrbough and Broadie, 2010, Benton et al., 2009, Frank et al., 2009, Karr et al., 2009, Kurshan et al., 2009, Lee et al., 2009, Rushton et al., 2009, Bogdanik et al., 2008, Chai et al., 2008, Miech et al., 2008, Schmid et al., 2008, Heckscher et al., 2007, Pack-Chung et al., 2007, Pan and Broadie, 2007, Rohrbough et al., 2007, Ataman et al., 2006, Schmid et al., 2006, Wagh et al., 2006, Chen et al., 2005, Rasse et al., 2005)

GluRIIC/III

(Verstreken et al., 2009)

GluRIIc

(Krick et al., 2021)

GlutRIII

(Bao et al., 2005)

glutamate receptor III

(Viquez et al., 2006)

Name Synonyms

Glutamate receptor IIC

(Tsubouchi et al., 2012, Saitoe et al., 2001)

Glutamate receptor III

(Tsurudome et al., 2010, Marrus et al., 2004)

common type III glutamate receptor subunit

(Miller et al., 2012)

essential glutamate receptor subunit III

(Blunk et al., 2014)

glutamate receptor

(Verstreken and Bellen, 2002)

glutamate receptor IIC

(Lee et al., 2013)

glutamate receptor III

(Bao et al., 2007)

glutamate receptor subunit III

(Kern et al., 2013)

Secondary FlyBase IDs

FBgn0031293

Datasets (2)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (2)

Result

Result Type

Title

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

References (159)

The following external sites may use different assemblies or annotations than FlyBase.

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