FB2020_02, released Apr 14, 2020

Gene: Dmel\GluRIIC

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General Information
Symbol
Dmel\GluRIIC
Species
D. melanogaster
Name
Glutamate receptor IIC
Annotation Symbol
CG4226
Feature Type
protein_coding_gene
FlyBase ID
FBgn0046113
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As

GluRIII, DGluRIII, DGluRIIC, GluRII-C, glutamate receptor III

Key Links
Genomic Location
Cytogenetic map
21E2-21E2
Sequence location
2L:914,086..917,805 [+]
Recombination map

2-1.5

RefSeq locus
NT_033779 REGION:914086..917805
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
glutamate-gated calcium ion channel activity
Predictions / Assertions
glutamate receptor activity; ionotropic glutamate receptor activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity; signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Summaries
Gene Group (FlyBase)
NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS - GLURII NEUROMUSCULAR JUNCTION-SUBTYPE -
In Drosophila, neuromuscular junction type A and type B glutamate receptors are heterotetramers assembled from either GluRIIA or GluRIIB plus other GluRII subunits. In response to the neurotransmitter, glutamate, they conduct Ca2+. (Adapted from FBrf0228432).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\GluRIIC or the JBrowse view of Dmel\GluRIIC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
GluRIIC-RD
FBtr0336969
NM_134713
3004
940
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
GluRIIC-PD
FBpp0307912
106.8
940
5.71
NP_608557
AAF51433
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments

Antibody raised to C-terminal peptide -QGSGSSSGSNNAGRGEKEARV

(Marrus et al., 2004)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GluRIIC using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (20 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
glutamate-gated calcium ion channel activity
inferred from direct assay
(Han et al., 2015)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
glutamate receptor activity
non-traceable author statement
(Saitoe et al., 2001)
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
ionotropic glutamate receptor activity
inferred by curator from GO:0008328
(Qin et al., 2005)
kainate selective glutamate receptor activity
inferred from sequence or structural similarity
(Littleton and Ganetzky, 2000)
ligand-gated ion channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
signaling receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
calcium ion transport
inferred from direct assay
(Han et al., 2015)
chemical synaptic transmission
inferred from mutant phenotype
(Marrus et al., 2004)
establishment of protein localization
inferred from mutant phenotype
(Marrus et al., 2004)
neuromuscular synaptic transmission
inferred from expression pattern
(Qin et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
modulation of chemical synaptic transmission
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
synaptic transmission, glutamatergic
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred by curator from GO:0007274,GO:0008328
(Qin et al., 2005)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
ionotropic glutamate receptor complex
inferred from mutant phenotype
(Qin et al., 2005)
muscle cell postsynaptic specialization
inferred from direct assay
(Qin et al., 2005)
neuromuscular junction
inferred from direct assay
(Karr et al., 2009)
synapse
inferred from direct assay
(Marrus et al., 2004)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
postsynaptic density membrane
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
postsynaptic membrane
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval neuromuscular junction

Comment: of all the muscles and from both type Ib and Is motoneurons.

(Marrus and DiAntonio, 2004)
somatic muscle
(Marrus et al., 2004)
somatic muscle
(Marrus et al., 2004)
somatic muscle
(Marrus et al., 2004)
somatic muscle
(Marrus et al., 2004)
somatic muscle
(Marrus et al., 2004)
synapse | restricted

Comment: Postsynaptic.

(Graf et al., 2009)
larval stage
somatic muscle
(Qin et al., 2005)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Qin et al., 2005)
Additional Descriptive Data

GluRIIC has punctate expression that fails to colocalize with Fas2 at the larval neuromuscular junction. Immunolocalization is observed postsynaptically at type Ib, Is and type II synaptic terminal buttons.

(Marrus et al., 2004)
Marker for
 
embryonic/larval neuromuscular junction
(Mosca and Schwarz, 2010)
Subcellular Localization
CV Term
Evidence
References
ionotropic glutamate receptor complex
inferred from mutant phenotype
(Qin et al., 2005)
muscle cell postsynaptic specialization
inferred from direct assay
(Qin et al., 2005)
neuromuscular junction
inferred from direct assay
(Karr et al., 2009)
synapse
inferred from direct assay
(Marrus et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\GluRIIC in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of GluRIIC
Transgenic constructs containing regulatory region of GluRIIC
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW
lethal - all die before end of embryonic stage
lethal - all die before end of embryonic stage (with GluRIIC1)
lethal - all die before end of embryonic stage (with GluRIIC2)
viable, with Dcr-2UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
Other Phenotypes
Allele
neuroanatomy defective, with Df(2L)ast1/GluRIIC2, Scer\GAL4G14
neuroanatomy defective, with Scer\GAL4G14
neuroanatomy defective (with Df(2L)ast1), with GluRIICUAS.cMa, Scer\GAL4G14
neurophysiology defective, with Df(2L)ast1/GluRIIC2, Scer\GAL4- :
neurophysiology defective, with GluRIIC1/Df(2L)ast1, Scer\GAL4- :
neurophysiology defective, with Scer\GAL4C57
neurophysiology defective, with Scer\GAL4C57, Scer\GAL4elav-C155, Scer\GAL4sca.PC
neurophysiology defective (with Df(2L)ast1), with GluRIICUAS.cMa, Scer\GAL4- :
neurophysiology defective | third instar larval stage, with Scer\GAL4C57, Scer\GAL4elav-C155, Scer\GAL4sca.PC
paralytic | embryonic stage
some die during embryonic stage
some die during embryonic stage (with GluRIIC1)
some die during embryonic stage (with GluRIIC2)
Phenotype manifest in
Allele
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4C57, Scer\GAL4elav-C155, Scer\GAL4sca.PC
neuromuscular junction | larval stage, with Df(2L)ast1/GluRIIC2, Scer\GAL4- :
neuromuscular junction | larval stage, with GluRIIC1/Df(2L)ast1, Scer\GAL4- :
neuromuscular junction | larval stage (with Df(2L)ast1), with GluRIICUAS.cMa, Scer\GAL4- :
terminal bouton, with Df(2L)ast1/GluRIIC2, Scer\GAL4G14
terminal bouton, with Scer\GAL4G14
terminal bouton (with Df(2L)ast1), with GluRIICUAS.cMa, Scer\GAL4G14
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GRID2
4 of 15
Yes
Yes
Hsap\GRIK1
4 of 15
Yes
No
Hsap\GRIK2
4 of 15
Yes
No
Hsap\GRIK3
4 of 15
Yes
No
Hsap\GRIK4
4 of 15
Yes
No
Hsap\GRID1
3 of 15
No
No
Hsap\GRIK5
3 of 15
No
No
 
Hsap\GRIA1
2 of 15
No
No
 
Hsap\GRIA2
2 of 15
No
No
 
Hsap\GRIA3
2 of 15
No
No
Hsap\GRIA4
2 of 15
No
No
Hsap\GRIN2A
2 of 15
No
No
Hsap\GRIN2B
2 of 15
No
No
Hsap\GRIN2C
2 of 15
No
No
Hsap\GRIN2D
2 of 15
No
No
Hsap\GRIN3A
2 of 15
No
No
Hsap\GRIN3B
2 of 15
No
Yes
Hsap\ENPP2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Grik1
4 of 15
Yes
No
Mmus\Grik2
4 of 15
Yes
No
Mmus\Grik4
4 of 15
Yes
No
Mmus\Grik5
4 of 15
Yes
No
Mmus\Grid1
3 of 15
No
No
Mmus\Grid2
3 of 15
No
Yes
Mmus\Grik3
3 of 15
No
No
Mmus\Gria1
2 of 15
No
No
 
Mmus\Gria2
2 of 15
No
No
Mmus\Gria3
2 of 15
No
No
Mmus\Gria4
2 of 15
No
No
Mmus\Grin2a
2 of 15
No
No
Mmus\Grin2b
2 of 15
No
No
Mmus\Grin2c
2 of 15
No
No
Mmus\Grin2d
2 of 15
No
No
Mmus\Grin3a
2 of 15
No
No
Mmus\Grin3b
2 of 15
No
Yes
Rattus norvegicus (Norway rat) (17)
Rnor\Grik2
4 of 13
Yes
No
Rnor\Grik3
4 of 13
Yes
No
Rnor\Grik4
4 of 13
Yes
No
Rnor\Grik5
4 of 13
Yes
No
Rnor\Grid2
3 of 13
No
Yes
Rnor\Grik1
3 of 13
No
No
Rnor\Gria3
2 of 13
No
No
Rnor\Gria4
2 of 13
No
No
Rnor\Grin2a
2 of 13
No
No
Rnor\Grin2b
2 of 13
No
No
Rnor\Grin2c
2 of 13
No
No
Rnor\Grin2d
2 of 13
No
No
Rnor\Grin3a
2 of 13
No
Yes
Rnor\Grin3b
2 of 13
No
Yes
Rnor\Gria1
1 of 13
No
No
Rnor\Gria2
1 of 13
No
No
Rnor\Grid1
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (15)
Xtro\grik1
4 of 12
Yes
No
Xtro\grid1
3 of 12
No
Yes
Xtro\grid2
3 of 12
No
Yes
Xtro\grik4
3 of 12
No
No
Xtro\grik5-like.1
3 of 12
No
Yes
Xtro\gria1
2 of 12
No
No
Xtro\gria3
2 of 12
No
No
Xtro\gria4
2 of 12
No
No
Xtro\grin2b
2 of 12
No
No
Xtro\grin2c
2 of 12
No
No
Xtro\grin2d
2 of 12
No
No
Xtro\grin3b
2 of 12
No
Yes
Xtro\grik2
1 of 12
No
No
Xtro\grik3
1 of 12
No
No
Xtro\grik5
1 of 12
No
Yes
Danio rerio (Zebrafish) (32)
Drer\grik1a
4 of 15
Yes
No
Drer\grik1b
4 of 15
Yes
No
Drer\grik4
4 of 15
Yes
No
Drer\LOC100334689
4 of 15
Yes
No
Drer\grid1a
3 of 15
No
Yes
Drer\grid1b
3 of 15
No
Yes
Drer\grid2
3 of 15
No
Yes
Drer\grik2
3 of 15
No
No
Drer\grik5
3 of 15
No
No
Drer\LOC100331381
3 of 15
No
No
Drer\si:ch211-251b21.1
3 of 15
No
Yes
Drer\si:dkey-183j2.10
3 of 15
No
Yes
Drer\gria1a
2 of 15
No
No
Drer\gria1b
2 of 15
No
No
Drer\gria2a
2 of 15
No
No
Drer\gria2b
2 of 15
No
No
Drer\gria3a
2 of 15
No
No
Drer\gria3b
2 of 15
No
No
Drer\gria4b
2 of 15
No
No
Drer\grin2aa
2 of 15
No
No
Drer\grin2ab
2 of 15
No
No
Drer\grin2bb
2 of 15
No
No
Drer\grin2ca
2 of 15
No
No
Drer\grin2cb
2 of 15
No
No
Drer\grin2da
2 of 15
No
No
Drer\grin3a
2 of 15
No
Yes
Drer\grin3ba
2 of 15
No
Yes
Drer\LOC100149482
2 of 15
No
No
Drer\gria4a
1 of 15
No
No
Drer\grin3bb
1 of 15
No
Yes
Drer\LOC100537813
1 of 15
No
No
Drer\LOC110438919
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\glr-5
4 of 15
Yes
No
Cele\glr-6
4 of 15
Yes
Yes
Cele\glr-3
3 of 15
No
No
Cele\glr-4
3 of 15
No
No
Cele\glr-8
3 of 15
No
Yes
Cele\C08B6.5
1 of 15
No
No
Cele\F59E12.8
1 of 15
No
Yes
Cele\glr-1
1 of 15
No
No
Cele\glr-2
1 of 15
No
No
Cele\glr-7
1 of 15
No
No
Cele\nmr-2
1 of 15
No
No
Cele\spp-22
1 of 15
No
Yes
Cele\T25E4.2
1 of 15
No
Yes
Cele\W02A2.5
1 of 15
No
No
Cele\ZK867.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (20)
Atha\ATGLR1.2
2 of 9
Yes
No
Atha\GLR1.1
2 of 9
Yes
No
Atha\GLR1.3
2 of 9
Yes
No
Atha\GLR1.4
2 of 9
Yes
No
Atha\GLR2.1
2 of 9
Yes
No
Atha\GLR2.2
2 of 9
Yes
No
Atha\GLR2.3
2 of 9
Yes
No
Atha\GLR2.4
2 of 9
Yes
No
Atha\GLR2.5
2 of 9
Yes
No
Atha\GLR2.6
2 of 9
Yes
No
Atha\GLR2.7
2 of 9
Yes
No
Atha\GLR2.8
2 of 9
Yes
No
Atha\GLR2.9
2 of 9
Yes
No
Atha\GLR2
2 of 9
Yes
No
Atha\GLR3.3
2 of 9
Yes
No
Atha\GLR3.4
2 of 9
Yes
No
Atha\GLR3.5
2 of 9
Yes
No
Atha\GLR3.6
2 of 9
Yes
No
Atha\GLR5
2 of 9
Yes
No
Atha\GLUR2
2 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901MF )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000100
Drosophila simulans
Dsim\GD23060
Drosophila sechellia
Dsec\GM16780
Drosophila erecta
Dere\GG24758
Drosophila yakuba
Dyak\GE17232
Drosophila ananassae
Dana\GF15073
Drosophila pseudoobscura pseudoobscura
Dpse\GA18046
Drosophila persimilis
Dper\GL16417
Drosophila willistoni
Dwil\GK24445
Drosophila virilis
Dvir\GJ17806
Drosophila mojavensis
Dmoj\GI21873
Drosophila grimshawi
Dgri\GH11254
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500XE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022612
Glossina morsitans
Tsetse fly
Gmor\GMOY012186
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14390
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (43)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
clumsy
5 of 10
Ekar
5 of 10
GluRIIA
5 of 10
GluRIIB
5 of 10
CG11155
4 of 10
GluRIID
4 of 10
GluRIIE
4 of 10
Grik
4 of 10
Ir25a
4 of 10
GluRIA
3 of 10
GluRIB
3 of 10
Ir64a
3 of 10
Ir75a
3 of 10
Ir75c
3 of 10
Ir75d
3 of 10
Ir76b
3 of 10
Ir84a
3 of 10
Ir93a
3 of 10
KaiR1D
3 of 10
Nmdar2
3 of 10
Ir7b
2 of 10
Ir7c
2 of 10
Ir7d
2 of 10
Ir7e
2 of 10
Ir7f
2 of 10
Ir7g
2 of 10
Ir8a
2 of 10
Ir21a
2 of 10
Ir31a
2 of 10
Ir60a
2 of 10
Ir68a
2 of 10
Ir75b
2 of 10
Ir85a
2 of 10
Nmdar1
2 of 10
Ir7a
1 of 10
Ir11a
1 of 10
Ir40a
1 of 10
Ir41a
1 of 10
Ir68b
1 of 10
Ir76a
1 of 10
Ir87a
1 of 10
Ir92a
1 of 10
Ir94d
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GRID2; glutamate ionotropic receptor delta type subunit 2
    4 of 15
    602368
    GRIK1; glutamate ionotropic receptor kainate type subunit 1
    4 of 15
    138245
        GRIK2; glutamate ionotropic receptor kainate type subunit 2
        4 of 15
        138244
        GRIK3; glutamate ionotropic receptor kainate type subunit 3
        4 of 15
        138243
            GRIK4; glutamate ionotropic receptor kainate type subunit 4
            4 of 15
            600282
                GRID1; glutamate ionotropic receptor delta type subunit 1
                3 of 15
                610659
                    GRIK5; glutamate ionotropic receptor kainate type subunit 5
                    3 of 15
                    600283
                         
                        Functional Complementation Data
                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                        Interactions
                        Summary of Physical Interactions
                        esyN Network Diagram
                        Show neighbor-neighbor interactions:
                        Select Layout:
                        Legend:
                        Protein
                        RNA
                        Selected Interactor(s)
                        Interactions Browser
                        View in Interactions Browser
                        Please see the Physical Interaction reports below for full details
                        protein-protein
                        Physical Interaction
                        Assay
                        References
                        GluRIIC - Neto
                        anti tag coimmunoprecipitation, western blot
                        (Kim et al., 2015)
                        GluRIIC - cora
                        two hybrid
                        (Chen et al., 2005)
                        Summary of Genetic Interactions
                        esyN Network Diagram
                        esyN Network Key:
                        Suppression
                        Enhancement
                        View in Interactions Browser
                        Please look at the allele data for full details of the genetic interactions
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        cac
                        enhanceable
                        GluRIIC
                        (Brusich et al., 2015)
                        External Data
                        Linkouts
                        DroID - A comprehensive database of gene and protein interactions.
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Pathways
                        Signaling Pathways (FlyBase)
                        Metabolic Pathways
                        External Data
                        Linkouts
                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                        Genomic Location and Detailed Mapping Data
                        Chromosome (arm)
                        2L
                        Recombination map

                        2-1.5

                        Cytogenetic map
                        21E2-21E2
                        Sequence location
                        2L:914,086..917,805 [+]
                        FlyBase Computed Cytological Location
                        Cytogenetic map
                        Evidence for location
                        21E2-21E2
                        Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
                        Experimentally Determined Cytological Location
                        Cytogenetic map
                        Notes
                        References
                        Experimentally Determined Recombination Data
                        Location

                        2-1.5

                        (FlyBase, 2016)

                        2-1.0

                        (Comeron et al., 2012)
                        Left of (cM)
                        Right of (cM)
                        Notes
                        Stocks and Reagents
                        Stocks (6)
                        Genomic Clones (11)
                         

                        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                        cDNA Clones (13)
                         

                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                        cDNA clones, fully sequences
                        BDGP DGC clones
                        Other clones
                          Drosophila Genomics Resource Center cDNA clones

                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                          cDNA Clones, End Sequenced (ESTs)
                          BDGP DGC clones
                          Other clones
                          RNAi and Array Information
                          Linkouts
                          DRSC - Results frm RNAi screens
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          Antibody Information
                          Laboratory Generated Antibodies
                           

                          polyclonal

                          (Ramos et al., 2015, Sulkowski et al., 2014, Kern et al., 2013, Natarajan et al., 2013, Qin et al., 2005, Marrus and DiAntonio, 2004, Marrus et al., 2004)
                          Commercially Available Antibodies
                           
                          Other Information
                          Relationship to Other Genes
                          Source for database identify of

                          Source for identity of: GluRIII CG4226

                          (Marrus et al., 2004)
                          Source for database merge of

                          Source for merge of: GluRIIC GluRIII

                          (Qin et al., 2005)
                          Additional comments
                          Other Comments

                          GluRIIC is required for synaptic localisation of GluRIIA and GluRIIB proteins. Either GluRIIA or GluRIIB, but not both, is required for synaptic localisation of GluRIIC protein. GluRIIA and GluRIIB proteins compete with each other for access to GluRIIC protein and subsequent localisation to the synapse.

                          (Marrus et al., 2004)

                          GluRIIC is required for synaptic transmission at the neuromuscular junction.

                          (Marrus et al., 2004)
                          Origin and Etymology
                          Discoverer
                          Etymology
                          Identification
                          External Crossreferences and Linkouts ( 33 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          modMine - A data warehouse for the modENCODE project
                          Linkouts
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          FlyMine - An integrated database for Drosophila genomics
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          Synonyms and Secondary IDs (23)
                          Reported As
                          Symbol Synonym
                          CG4226
                          (Kondo et al., 2020, Hu et al., 2015, Tsubouchi et al., 2012, Croset et al., 2010, Benton et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Gonzalez et al., 2004, Marrus et al., 2004)
                          CT13021
                          (Littleton and Ganetzky, 2000)
                          DGluR-IIC
                          (Saitoe et al., 2001)
                          DGluRIIC
                          (Lee and Wu, 2010, Lee et al., 2008, Saitoe et al., 2001)
                          DGluRIII
                          (Bae et al., 2016, Chen et al., 2015, Blunk et al., 2014, Bulat et al., 2014, Roy and Jackson, 2014, Enneking et al., 2013, Natarajan et al., 2013, Graf et al., 2012, Mosca et al., 2012, Graf et al., 2011, Kim et al., 2010, Graf et al., 2009, Viquez et al., 2009, Wairkar et al., 2008, Dickman, 2006, Dickman et al., 2006, Marrus and Diantonio, 2005, Griffith, 2004, Marrus and DiAntonio, 2004)
                          DmelGluRIIC
                          (Croset et al., 2010)
                          GLURIIC
                          (Jepson et al., 2014, Schwenkert et al., 2008)
                          GluR
                          (Heckscher et al., 2007)
                          GluR3
                          (Graham et al., 2010)
                          GluRC
                          (Estes et al., 2013)
                          GluRII-C
                          (Frank et al., 2009, Pielage et al., 2006)
                          GluRIIC
                          (Kondo et al., 2020, Patrón et al., 2019, Rao and Deng, 2019.10.23, Gene Disruption Project members, 2018-, Bulgakova et al., 2017, Wang et al., 2017, Sarov et al., 2016, Ziegler et al., 2016, Hu et al., 2015, Kim et al., 2015, Koles et al., 2015, Ramos et al., 2015, Gardiol and St Johnston, 2014, Ghosh et al., 2014, Machamer et al., 2014, Peled et al., 2014, Sulkowski et al., 2014, Castellanos et al., 2013, Estes et al., 2013, Lee et al., 2013, Nahm et al., 2013, Rohrbough et al., 2013, Bruckner et al., 2012, Chen and Ganetzky, 2012, Japanese National Institute of Genetics, 2012.5.21, Jordán-Álvarez et al., 2012, Kim et al., 2012, Rushton et al., 2012, Tsubouchi et al., 2012, Cheng et al., 2011, Ganesan et al., 2011, Banovic et al., 2010, Chen et al., 2010, Croset et al., 2010, Higashi-Kovtun et al., 2010, Mosca and Schwarz, 2010, Nahm et al., 2010, Rohrbough and Broadie, 2010, Benton et al., 2009, Frank et al., 2009, Karr et al., 2009, Kurshan et al., 2009, Lee et al., 2009, Rushton et al., 2009, Bogdanik et al., 2008, Chai et al., 2008, Miech et al., 2008, Schmid et al., 2008, Heckscher et al., 2007, Pack-Chung et al., 2007, Pan and Broadie, 2007, Rohrbough et al., 2007, Ataman et al., 2006, Schmid et al., 2006, Wagh et al., 2006, Chen et al., 2005, Rasse et al., 2005)
                          GluRIIC/III
                          (Verstreken et al., 2009)
                          GluRIII
                          (Chen et al., 2019, James et al., 2019, Mallik et al., 2017, Perry et al., 2017, Harris et al., 2016, Spring et al., 2016, Brusich et al., 2015, Machamer et al., 2014, Castellanos et al., 2013, Kern et al., 2013, Chen et al., 2012, Dickman et al., 2012, Fukui et al., 2012, Miller et al., 2012, James and Broihier, 2011, Miśkiewicz et al., 2011, Sun et al., 2011, Ball et al., 2010, Tsurudome et al., 2010, Ramachandran et al., 2009, Wairkar et al., 2009, Chai et al., 2008, Crisp et al., 2008, Mendoza-Topaz et al., 2008, Ohyama et al., 2007, Ataman, 2006, Johnson et al., 2006, Loewen et al., 2006)
                          GlutRIII
                          (Bao et al., 2005)
                          glutamate receptor III
                          (Viquez et al., 2006)
                          Name Synonyms
                          Glutamate receptor IIC
                          (Tsubouchi et al., 2012, Saitoe et al., 2001)
                          Glutamate receptor III
                          (Tsurudome et al., 2010, Marrus et al., 2004)
                          common type III glutamate receptor subunit
                          (Miller et al., 2012)
                          essential glutamate receptor subunit III
                          (Blunk et al., 2014)
                          glutamate receptor
                          (Verstreken and Bellen, 2002)
                          glutamate receptor IIC
                          (Lee et al., 2013)
                          glutamate receptor III
                          (Bao et al., 2007)
                          glutamate receptor subunit III
                          (Kern et al., 2013)
                          Secondary FlyBase IDs
                          • FBgn0031293
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          References (146)